G. Ulsh, Dung Le, J. Moy, M. McDermott, G. Collins
ChitO2-Clot is a novel hemostatic wound dressing. ChitO2-Clot will help facilitate coagulation/clot formation as well as providing oxygen to the wound, all while being cost effective and competitive with current hemostatic dressings. The product is composed of a micro/nano sized fibrous mat made of chitosan that is doped with Perfluorocarbons (oxygen carrier). The user would pack a hemorrhaging wound with ChitO2-Clot in order to stop the bleeding. The chitosan in ChitO2-Clot rapidly absorbs the blood in the wound bed and forms a gelatinous clot that fills the empty void of the wound. The gelatinous clot filling this void in the tissue applies pressure to the damaged vasculature, which prevents further bleeding. Chitosan also activates the clot clotting cascade and causes the agglutination of red blood cells, accelerates coagulation in vivo by influencing the activation of platelets. The Perfluorocarbons (oxygen career) release oxygen into the wound bed to help facilitate the wound healing process. Over time, the chitosan in ChitO2-Clot will be reabsorbed by the body and converted into sugar, while the Perfluorocarbon (PFC) is expelled via gas exchange in the lungs.
{"title":"ChitO2-Clot: A Novel Hemostatic and Oxygen Releasing Biomaterial for Traumatic Injuries","authors":"G. Ulsh, Dung Le, J. Moy, M. McDermott, G. Collins","doi":"10.1109/NEBEC.2013.67","DOIUrl":"https://doi.org/10.1109/NEBEC.2013.67","url":null,"abstract":"ChitO2-Clot is a novel hemostatic wound dressing. ChitO2-Clot will help facilitate coagulation/clot formation as well as providing oxygen to the wound, all while being cost effective and competitive with current hemostatic dressings. The product is composed of a micro/nano sized fibrous mat made of chitosan that is doped with Perfluorocarbons (oxygen carrier). The user would pack a hemorrhaging wound with ChitO2-Clot in order to stop the bleeding. The chitosan in ChitO2-Clot rapidly absorbs the blood in the wound bed and forms a gelatinous clot that fills the empty void of the wound. The gelatinous clot filling this void in the tissue applies pressure to the damaged vasculature, which prevents further bleeding. Chitosan also activates the clot clotting cascade and causes the agglutination of red blood cells, accelerates coagulation in vivo by influencing the activation of platelets. The Perfluorocarbons (oxygen career) release oxygen into the wound bed to help facilitate the wound healing process. Over time, the chitosan in ChitO2-Clot will be reabsorbed by the body and converted into sugar, while the Perfluorocarbon (PFC) is expelled via gas exchange in the lungs.","PeriodicalId":153112,"journal":{"name":"2013 39th Annual Northeast Bioengineering Conference","volume":"221 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121350820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Michael Shockley, C. Mcgoverin, U. Palukuru, Padraig B. M. Glenn, N. Pleshko, Richard Spencer
Tissue engineering is complicated by the plethora of factors which may influence the growth of tissue constructs. The potential of near infrared spectroscopy for the non-destructive periodic monitoring of engineered cartilage constructs was investigated. Spectral changes attributed to increased collagen and proteoglycan and decreased polyglycolic acid content were observed and were correlated to physical parameters of developing cartilage.
{"title":"Near Infrared Spectroscopy as a Method for Non-Destructive Monitoring of Engineered Cartilage Growth","authors":"Michael Shockley, C. Mcgoverin, U. Palukuru, Padraig B. M. Glenn, N. Pleshko, Richard Spencer","doi":"10.1109/NEBEC.2013.119","DOIUrl":"https://doi.org/10.1109/NEBEC.2013.119","url":null,"abstract":"Tissue engineering is complicated by the plethora of factors which may influence the growth of tissue constructs. The potential of near infrared spectroscopy for the non-destructive periodic monitoring of engineered cartilage constructs was investigated. Spectral changes attributed to increased collagen and proteoglycan and decreased polyglycolic acid content were observed and were correlated to physical parameters of developing cartilage.","PeriodicalId":153112,"journal":{"name":"2013 39th Annual Northeast Bioengineering Conference","volume":"181 4","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133292879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Attention Deficit Hyperactivity Disorder (ADHD) is a common learning disability in many children and adults. A prototype device, the F.O.C.U.S., was developed to help improve the academic performance of students with this disorder. Further development of the F.O.C.U.S. consists of enhancing the current prototype to make it non-stigmatizing so that undergraduate students with ADHD can use it to help them improve their academic performance. A customer needs survey was distributed to students registered with Student Disability Services to determine aspects of the device. The device will include the eZ430-Chronos Development Tool (digital watch) which will control peripheral devices that will be set on the desk of the student. These peripheral devices can be prompted via the wireless signal from the watch to distribute reminder signals such as vibrations, beeping sounds, and flashing light.
{"title":"Further Development of the F.O.C.U.S.: Facilitating On-going Concentration in Undergraduate Students","authors":"M. L. Thomas, J. Cezeaux","doi":"10.1109/NEBEC.2013.19","DOIUrl":"https://doi.org/10.1109/NEBEC.2013.19","url":null,"abstract":"Attention Deficit Hyperactivity Disorder (ADHD) is a common learning disability in many children and adults. A prototype device, the F.O.C.U.S., was developed to help improve the academic performance of students with this disorder. Further development of the F.O.C.U.S. consists of enhancing the current prototype to make it non-stigmatizing so that undergraduate students with ADHD can use it to help them improve their academic performance. A customer needs survey was distributed to students registered with Student Disability Services to determine aspects of the device. The device will include the eZ430-Chronos Development Tool (digital watch) which will control peripheral devices that will be set on the desk of the student. These peripheral devices can be prompted via the wireless signal from the watch to distribute reminder signals such as vibrations, beeping sounds, and flashing light.","PeriodicalId":153112,"journal":{"name":"2013 39th Annual Northeast Bioengineering Conference","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132102113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jonathan B. Matheny, Craig R. Slyfield, E. V. Tkachenko, I. Lin, Amanda R. Bouman, K. M. Ehlert, C. Hernandez, R. Tomlinson, D. Wilson
Raloxifene treatment increases bone strength more than would be expected from changes in bone mass or bone turnover A possible mechanism through which raloxifene treatment increases bone strength independent of bone mass and bone turnover is by reducing the size of resorption cavities formed during bone remodeling. A novel three-dimensional dynamic bone histomorphometry approach was used to determine the effects of raloxifene treatment on the threedimensional size of individual bone remodeling events (both resorption cavities and subsequent bone formation events) in cancellous bone using an ovariectomized rat model. Raloxifene treated animals were found to have reduced cavity volume and maximum cavity depth compared to both ovariectomized and sham control groups. Sham control and raloxifene treated animals also have reduced formation event size compared to OVX animals. Raloxifene leads to reduced size of remodeling events compared to ovariectomized and sham controls. Differences in cavity size may influence subsequent bone biomechanical performance independent of bone turnover.
{"title":"Reduction in Resorption Cavity Size following Anti-Resorptive Drug Treatment","authors":"Jonathan B. Matheny, Craig R. Slyfield, E. V. Tkachenko, I. Lin, Amanda R. Bouman, K. M. Ehlert, C. Hernandez, R. Tomlinson, D. Wilson","doi":"10.1109/NEBEC.2013.165","DOIUrl":"https://doi.org/10.1109/NEBEC.2013.165","url":null,"abstract":"Raloxifene treatment increases bone strength more than would be expected from changes in bone mass or bone turnover A possible mechanism through which raloxifene treatment increases bone strength independent of bone mass and bone turnover is by reducing the size of resorption cavities formed during bone remodeling. A novel three-dimensional dynamic bone histomorphometry approach was used to determine the effects of raloxifene treatment on the threedimensional size of individual bone remodeling events (both resorption cavities and subsequent bone formation events) in cancellous bone using an ovariectomized rat model. Raloxifene treated animals were found to have reduced cavity volume and maximum cavity depth compared to both ovariectomized and sham control groups. Sham control and raloxifene treated animals also have reduced formation event size compared to OVX animals. Raloxifene leads to reduced size of remodeling events compared to ovariectomized and sham controls. Differences in cavity size may influence subsequent bone biomechanical performance independent of bone turnover.","PeriodicalId":153112,"journal":{"name":"2013 39th Annual Northeast Bioengineering Conference","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115265585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The basic bedpan design in current use has changed little in the last century. The Smart-Pan, a Bedpan Management System, creates the basic command structure for a waste removal system in hospital beds that could ultimately replace the manual bedpan system.
{"title":"Smart-Pan: Bedpan Management System","authors":"N. T. Faulkner, J. Lacourse, R. Shippee-Rice","doi":"10.1109/NEBEC.2013.139","DOIUrl":"https://doi.org/10.1109/NEBEC.2013.139","url":null,"abstract":"The basic bedpan design in current use has changed little in the last century. The Smart-Pan, a Bedpan Management System, creates the basic command structure for a waste removal system in hospital beds that could ultimately replace the manual bedpan system.","PeriodicalId":153112,"journal":{"name":"2013 39th Annual Northeast Bioengineering Conference","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123502827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The prevalence of calcific aortic valve disease is rising and is only treatable by surgical replacement of the stenotic valve. There is currently no biomarker or pharmacological therapy available for the treatment of early aortic valve disease and this is largely due to our limited understanding of the disease mechanisms. One potential mechanism of valve repair and potentially early valve disease is endothelial-to-mesenchymal transformation (EndMT), the initiating event of valvulogenesis. Our preliminary work has shown that extracellular matrix (ECM) composition that mimics diseased valve conditions strongly stimulates mesenchymal transformation. EndMT may be a mechanism for signaling valve interstitial cells toward either valve regeneration or disease and growing evidence indicates that communication between the interstitial cells and the endothelial cells is essential for valve homeostasis. Unfortunately, there is currently no known unifying mechanism of valve disease that connects endothelial cell dysfunction, interstitial cell differentiation, and pathological matrix remodeling. Our research seeks to reveal this mechanism using novel, unique to our laboratory tools, greatly facilitating the discovery and new clinical strategies for controlling early-detected valve disease with minimally invasive interventions.
{"title":"Role of Biochemical and Biophysical Factors on Endothelial-to-Mesenchymal Transformation","authors":"S. Dahal, Gretchen J. Mahler","doi":"10.1109/NEBEC.2013.135","DOIUrl":"https://doi.org/10.1109/NEBEC.2013.135","url":null,"abstract":"The prevalence of calcific aortic valve disease is rising and is only treatable by surgical replacement of the stenotic valve. There is currently no biomarker or pharmacological therapy available for the treatment of early aortic valve disease and this is largely due to our limited understanding of the disease mechanisms. One potential mechanism of valve repair and potentially early valve disease is endothelial-to-mesenchymal transformation (EndMT), the initiating event of valvulogenesis. Our preliminary work has shown that extracellular matrix (ECM) composition that mimics diseased valve conditions strongly stimulates mesenchymal transformation. EndMT may be a mechanism for signaling valve interstitial cells toward either valve regeneration or disease and growing evidence indicates that communication between the interstitial cells and the endothelial cells is essential for valve homeostasis. Unfortunately, there is currently no known unifying mechanism of valve disease that connects endothelial cell dysfunction, interstitial cell differentiation, and pathological matrix remodeling. Our research seeks to reveal this mechanism using novel, unique to our laboratory tools, greatly facilitating the discovery and new clinical strategies for controlling early-detected valve disease with minimally invasive interventions.","PeriodicalId":153112,"journal":{"name":"2013 39th Annual Northeast Bioengineering Conference","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130478262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Inflammation and infection of catheters (and polymeric medical devices in general) is a significant problem. Previous studies have demonstrated that metals with nanotubular surface features can decrease both inflammatory and bacteria functions. With this in mind, this study aimed to create polydimethylsiloxane (PDMS)/polyvinyl chloride (PVC) molds out of anodized titanium (Ti) in order to transfer this novel antibacterial surface roughness to polymers. In addition, such polymers were further tested for inflammatory and bacteria responses.
{"title":"Preparation of Nanotubular PDMS/PVC Molds for Reduced Catheter Inflammation and Infection","authors":"Luting Liu, T. Webster","doi":"10.1109/NEBEC.2013.128","DOIUrl":"https://doi.org/10.1109/NEBEC.2013.128","url":null,"abstract":"Inflammation and infection of catheters (and polymeric medical devices in general) is a significant problem. Previous studies have demonstrated that metals with nanotubular surface features can decrease both inflammatory and bacteria functions. With this in mind, this study aimed to create polydimethylsiloxane (PDMS)/polyvinyl chloride (PVC) molds out of anodized titanium (Ti) in order to transfer this novel antibacterial surface roughness to polymers. In addition, such polymers were further tested for inflammatory and bacteria responses.","PeriodicalId":153112,"journal":{"name":"2013 39th Annual Northeast Bioengineering Conference","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128700605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
V. P. Jani, R. Patel, R. K. Reddy, L. Zhang, C. T. Wagner, C. Yan
Drug delivery to a biological system within the body requires precise control. Hybrid tissue scaffolds, manufactured via electrospinning, may be used in effective treatment of peripheral nerve damage. This study describes the development of such a scaffold, its characterization, and in vitro effectiveness; including the creation of an electrospinning apparatus capable of creating the tissue scaffold via coaxial spinning of biomaterials, material selection and testing, as well as mathematical modeling of the drug delivery profile.
{"title":"Development and Study of a Hybrid Tissue Scaffold Fabrication System for Neurotrophin Delivery","authors":"V. P. Jani, R. Patel, R. K. Reddy, L. Zhang, C. T. Wagner, C. Yan","doi":"10.1109/NEBEC.2013.79","DOIUrl":"https://doi.org/10.1109/NEBEC.2013.79","url":null,"abstract":"Drug delivery to a biological system within the body requires precise control. Hybrid tissue scaffolds, manufactured via electrospinning, may be used in effective treatment of peripheral nerve damage. This study describes the development of such a scaffold, its characterization, and in vitro effectiveness; including the creation of an electrospinning apparatus capable of creating the tissue scaffold via coaxial spinning of biomaterials, material selection and testing, as well as mathematical modeling of the drug delivery profile.","PeriodicalId":153112,"journal":{"name":"2013 39th Annual Northeast Bioengineering Conference","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124602126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
We present a work in progress of a single-channel electroencephalograph (EEG) system used in a multiple modality platform for epileptic seizure detection. This system consists of an EEG amplifier circuit that provides signal gain and filtering and a myDAQ unit that both simulates and acquires EEG signals which is controlled by a LabVIEW graphical program that performs feature extraction and signal classification. We describe the desired performance for the amplifier circuit and present preliminary measurement results and output examples from the amplifier circuit and LabVIEW program.
{"title":"Using myDAQ and LabVIEW to Develop a Single-Channel EEG for a Multi-modality Epileptic Seizure Detection Platform","authors":"David Wang, L. Khuon","doi":"10.1109/NEBEC.2013.35","DOIUrl":"https://doi.org/10.1109/NEBEC.2013.35","url":null,"abstract":"We present a work in progress of a single-channel electroencephalograph (EEG) system used in a multiple modality platform for epileptic seizure detection. This system consists of an EEG amplifier circuit that provides signal gain and filtering and a myDAQ unit that both simulates and acquires EEG signals which is controlled by a LabVIEW graphical program that performs feature extraction and signal classification. We describe the desired performance for the amplifier circuit and present preliminary measurement results and output examples from the amplifier circuit and LabVIEW program.","PeriodicalId":153112,"journal":{"name":"2013 39th Annual Northeast Bioengineering Conference","volume":"101 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127072144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Wang Ping, K. Low, J. Mclaren, Pascal Joubert des Ouches
NaTUre-gaits (Natural and TUnable rehabilitation gait system), has been developed for a robotic-assisted overground walking training. Effects on muscle activation of participants during walking with the system were evaluated and analyzed. Clinical trials were conducted and electromyographic (EMG) signals were collected from major lower limb muscle groups. Comparisons of muscle activation were provided between healthy and SCI/stroke participants walking with the device. Preliminary results showed that this device can provide a training effect to rehabilitation.
{"title":"Muscle Activation of Participants while Walking on a Robotic-Assisted Locomotion Training","authors":"Wang Ping, K. Low, J. Mclaren, Pascal Joubert des Ouches","doi":"10.1109/NEBEC.2013.26","DOIUrl":"https://doi.org/10.1109/NEBEC.2013.26","url":null,"abstract":"NaTUre-gaits (Natural and TUnable rehabilitation gait system), has been developed for a robotic-assisted overground walking training. Effects on muscle activation of participants during walking with the system were evaluated and analyzed. Clinical trials were conducted and electromyographic (EMG) signals were collected from major lower limb muscle groups. Comparisons of muscle activation were provided between healthy and SCI/stroke participants walking with the device. Preliminary results showed that this device can provide a training effect to rehabilitation.","PeriodicalId":153112,"journal":{"name":"2013 39th Annual Northeast Bioengineering Conference","volume":"os-57 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127718693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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