G. Ulsh, Dung Le, J. Moy, M. McDermott, G. Collins
ChitO2-Clot is a novel hemostatic wound dressing. ChitO2-Clot will help facilitate coagulation/clot formation as well as providing oxygen to the wound, all while being cost effective and competitive with current hemostatic dressings. The product is composed of a micro/nano sized fibrous mat made of chitosan that is doped with Perfluorocarbons (oxygen carrier). The user would pack a hemorrhaging wound with ChitO2-Clot in order to stop the bleeding. The chitosan in ChitO2-Clot rapidly absorbs the blood in the wound bed and forms a gelatinous clot that fills the empty void of the wound. The gelatinous clot filling this void in the tissue applies pressure to the damaged vasculature, which prevents further bleeding. Chitosan also activates the clot clotting cascade and causes the agglutination of red blood cells, accelerates coagulation in vivo by influencing the activation of platelets. The Perfluorocarbons (oxygen career) release oxygen into the wound bed to help facilitate the wound healing process. Over time, the chitosan in ChitO2-Clot will be reabsorbed by the body and converted into sugar, while the Perfluorocarbon (PFC) is expelled via gas exchange in the lungs.
{"title":"ChitO2-Clot: A Novel Hemostatic and Oxygen Releasing Biomaterial for Traumatic Injuries","authors":"G. Ulsh, Dung Le, J. Moy, M. McDermott, G. Collins","doi":"10.1109/NEBEC.2013.67","DOIUrl":"https://doi.org/10.1109/NEBEC.2013.67","url":null,"abstract":"ChitO2-Clot is a novel hemostatic wound dressing. ChitO2-Clot will help facilitate coagulation/clot formation as well as providing oxygen to the wound, all while being cost effective and competitive with current hemostatic dressings. The product is composed of a micro/nano sized fibrous mat made of chitosan that is doped with Perfluorocarbons (oxygen carrier). The user would pack a hemorrhaging wound with ChitO2-Clot in order to stop the bleeding. The chitosan in ChitO2-Clot rapidly absorbs the blood in the wound bed and forms a gelatinous clot that fills the empty void of the wound. The gelatinous clot filling this void in the tissue applies pressure to the damaged vasculature, which prevents further bleeding. Chitosan also activates the clot clotting cascade and causes the agglutination of red blood cells, accelerates coagulation in vivo by influencing the activation of platelets. The Perfluorocarbons (oxygen career) release oxygen into the wound bed to help facilitate the wound healing process. Over time, the chitosan in ChitO2-Clot will be reabsorbed by the body and converted into sugar, while the Perfluorocarbon (PFC) is expelled via gas exchange in the lungs.","PeriodicalId":153112,"journal":{"name":"2013 39th Annual Northeast Bioengineering Conference","volume":"221 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121350820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Michael Shockley, C. Mcgoverin, U. Palukuru, Padraig B. M. Glenn, N. Pleshko, Richard Spencer
Tissue engineering is complicated by the plethora of factors which may influence the growth of tissue constructs. The potential of near infrared spectroscopy for the non-destructive periodic monitoring of engineered cartilage constructs was investigated. Spectral changes attributed to increased collagen and proteoglycan and decreased polyglycolic acid content were observed and were correlated to physical parameters of developing cartilage.
{"title":"Near Infrared Spectroscopy as a Method for Non-Destructive Monitoring of Engineered Cartilage Growth","authors":"Michael Shockley, C. Mcgoverin, U. Palukuru, Padraig B. M. Glenn, N. Pleshko, Richard Spencer","doi":"10.1109/NEBEC.2013.119","DOIUrl":"https://doi.org/10.1109/NEBEC.2013.119","url":null,"abstract":"Tissue engineering is complicated by the plethora of factors which may influence the growth of tissue constructs. The potential of near infrared spectroscopy for the non-destructive periodic monitoring of engineered cartilage constructs was investigated. Spectral changes attributed to increased collagen and proteoglycan and decreased polyglycolic acid content were observed and were correlated to physical parameters of developing cartilage.","PeriodicalId":153112,"journal":{"name":"2013 39th Annual Northeast Bioengineering Conference","volume":"181 4","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133292879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Aguas, W. Dannhauser, R. Fox, M. Scalzi, S. Verdi
Approximately 19% of patients who receive a revision knee implant will require a reoperative revision surgery within 15-23 years [1]. In the current system, there is no gold standard for removing residual bone cement from the medullary canals, while minimizing the removal of healthy, organic bone. Designing a product that is easy to use by surgeons will ultimately reduce the chances for further complications following the revision surgery, and therefore, improve the quality of life for patients.
{"title":"A Novel Technique to Remove Bone Cement in Reoperative Revision Knee Arthroplasty","authors":"M. Aguas, W. Dannhauser, R. Fox, M. Scalzi, S. Verdi","doi":"10.1109/NEBEC.2013.43","DOIUrl":"https://doi.org/10.1109/NEBEC.2013.43","url":null,"abstract":"Approximately 19% of patients who receive a revision knee implant will require a reoperative revision surgery within 15-23 years [1]. In the current system, there is no gold standard for removing residual bone cement from the medullary canals, while minimizing the removal of healthy, organic bone. Designing a product that is easy to use by surgeons will ultimately reduce the chances for further complications following the revision surgery, and therefore, improve the quality of life for patients.","PeriodicalId":153112,"journal":{"name":"2013 39th Annual Northeast Bioengineering Conference","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114150153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
W. Marks, Tunc Kiymaz, Sze C. Yang, G. Dombi, S. Bhatia
The objective of this work is to examine the rheological properties of hydrogel comosites containing carbon nanobrushes. The composite, which is electrically conductive, is comprised of carbon nanobrushes embedded in a biocompatible poloxamer gel. This work assesses the ability of such composite gels to act as a matrix for tissue engineering, specifically for connective tissue. In such a model, chondrocytes would be seeded within the hydrogel matrix and then injected into the body. This work analyzes the rheological differences between hydrogels of different concentrations. The work also demonstrates that carbon nanobrushes can be dispersed within poloxamer gels. Previously it has been shown that fibroblasts and myocytes can proliferate within homogenously dispersed carbon nanobrush-containing poloxamer gels. Future work will examine the effects of design parameters including carbon nanobrush content and matrix structure on wound healing, chondrocyte proliferation within the hydrogel composites, and mechanical properties of the gels. This work has relevance for tissue engineering and tissue regeneration in clinical medicine.
{"title":"Rheological Analysis of Hydrogel Composites Containing Carbon Nanobrushes","authors":"W. Marks, Tunc Kiymaz, Sze C. Yang, G. Dombi, S. Bhatia","doi":"10.1109/NEBEC.2013.134","DOIUrl":"https://doi.org/10.1109/NEBEC.2013.134","url":null,"abstract":"The objective of this work is to examine the rheological properties of hydrogel comosites containing carbon nanobrushes. The composite, which is electrically conductive, is comprised of carbon nanobrushes embedded in a biocompatible poloxamer gel. This work assesses the ability of such composite gels to act as a matrix for tissue engineering, specifically for connective tissue. In such a model, chondrocytes would be seeded within the hydrogel matrix and then injected into the body. This work analyzes the rheological differences between hydrogels of different concentrations. The work also demonstrates that carbon nanobrushes can be dispersed within poloxamer gels. Previously it has been shown that fibroblasts and myocytes can proliferate within homogenously dispersed carbon nanobrush-containing poloxamer gels. Future work will examine the effects of design parameters including carbon nanobrush content and matrix structure on wound healing, chondrocyte proliferation within the hydrogel composites, and mechanical properties of the gels. This work has relevance for tissue engineering and tissue regeneration in clinical medicine.","PeriodicalId":153112,"journal":{"name":"2013 39th Annual Northeast Bioengineering Conference","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114338170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jonathan B. Matheny, Craig R. Slyfield, E. V. Tkachenko, I. Lin, Amanda R. Bouman, K. M. Ehlert, C. Hernandez, R. Tomlinson, D. Wilson
Raloxifene treatment increases bone strength more than would be expected from changes in bone mass or bone turnover A possible mechanism through which raloxifene treatment increases bone strength independent of bone mass and bone turnover is by reducing the size of resorption cavities formed during bone remodeling. A novel three-dimensional dynamic bone histomorphometry approach was used to determine the effects of raloxifene treatment on the threedimensional size of individual bone remodeling events (both resorption cavities and subsequent bone formation events) in cancellous bone using an ovariectomized rat model. Raloxifene treated animals were found to have reduced cavity volume and maximum cavity depth compared to both ovariectomized and sham control groups. Sham control and raloxifene treated animals also have reduced formation event size compared to OVX animals. Raloxifene leads to reduced size of remodeling events compared to ovariectomized and sham controls. Differences in cavity size may influence subsequent bone biomechanical performance independent of bone turnover.
{"title":"Reduction in Resorption Cavity Size following Anti-Resorptive Drug Treatment","authors":"Jonathan B. Matheny, Craig R. Slyfield, E. V. Tkachenko, I. Lin, Amanda R. Bouman, K. M. Ehlert, C. Hernandez, R. Tomlinson, D. Wilson","doi":"10.1109/NEBEC.2013.165","DOIUrl":"https://doi.org/10.1109/NEBEC.2013.165","url":null,"abstract":"Raloxifene treatment increases bone strength more than would be expected from changes in bone mass or bone turnover A possible mechanism through which raloxifene treatment increases bone strength independent of bone mass and bone turnover is by reducing the size of resorption cavities formed during bone remodeling. A novel three-dimensional dynamic bone histomorphometry approach was used to determine the effects of raloxifene treatment on the threedimensional size of individual bone remodeling events (both resorption cavities and subsequent bone formation events) in cancellous bone using an ovariectomized rat model. Raloxifene treated animals were found to have reduced cavity volume and maximum cavity depth compared to both ovariectomized and sham control groups. Sham control and raloxifene treated animals also have reduced formation event size compared to OVX animals. Raloxifene leads to reduced size of remodeling events compared to ovariectomized and sham controls. Differences in cavity size may influence subsequent bone biomechanical performance independent of bone turnover.","PeriodicalId":153112,"journal":{"name":"2013 39th Annual Northeast Bioengineering Conference","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115265585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The basic bedpan design in current use has changed little in the last century. The Smart-Pan, a Bedpan Management System, creates the basic command structure for a waste removal system in hospital beds that could ultimately replace the manual bedpan system.
{"title":"Smart-Pan: Bedpan Management System","authors":"N. T. Faulkner, J. Lacourse, R. Shippee-Rice","doi":"10.1109/NEBEC.2013.139","DOIUrl":"https://doi.org/10.1109/NEBEC.2013.139","url":null,"abstract":"The basic bedpan design in current use has changed little in the last century. The Smart-Pan, a Bedpan Management System, creates the basic command structure for a waste removal system in hospital beds that could ultimately replace the manual bedpan system.","PeriodicalId":153112,"journal":{"name":"2013 39th Annual Northeast Bioengineering Conference","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123502827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
V. P. Jani, R. Patel, R. K. Reddy, L. Zhang, C. T. Wagner, C. Yan
Drug delivery to a biological system within the body requires precise control. Hybrid tissue scaffolds, manufactured via electrospinning, may be used in effective treatment of peripheral nerve damage. This study describes the development of such a scaffold, its characterization, and in vitro effectiveness; including the creation of an electrospinning apparatus capable of creating the tissue scaffold via coaxial spinning of biomaterials, material selection and testing, as well as mathematical modeling of the drug delivery profile.
{"title":"Development and Study of a Hybrid Tissue Scaffold Fabrication System for Neurotrophin Delivery","authors":"V. P. Jani, R. Patel, R. K. Reddy, L. Zhang, C. T. Wagner, C. Yan","doi":"10.1109/NEBEC.2013.79","DOIUrl":"https://doi.org/10.1109/NEBEC.2013.79","url":null,"abstract":"Drug delivery to a biological system within the body requires precise control. Hybrid tissue scaffolds, manufactured via electrospinning, may be used in effective treatment of peripheral nerve damage. This study describes the development of such a scaffold, its characterization, and in vitro effectiveness; including the creation of an electrospinning apparatus capable of creating the tissue scaffold via coaxial spinning of biomaterials, material selection and testing, as well as mathematical modeling of the drug delivery profile.","PeriodicalId":153112,"journal":{"name":"2013 39th Annual Northeast Bioengineering Conference","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124602126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Inflammation and infection of catheters (and polymeric medical devices in general) is a significant problem. Previous studies have demonstrated that metals with nanotubular surface features can decrease both inflammatory and bacteria functions. With this in mind, this study aimed to create polydimethylsiloxane (PDMS)/polyvinyl chloride (PVC) molds out of anodized titanium (Ti) in order to transfer this novel antibacterial surface roughness to polymers. In addition, such polymers were further tested for inflammatory and bacteria responses.
{"title":"Preparation of Nanotubular PDMS/PVC Molds for Reduced Catheter Inflammation and Infection","authors":"Luting Liu, T. Webster","doi":"10.1109/NEBEC.2013.128","DOIUrl":"https://doi.org/10.1109/NEBEC.2013.128","url":null,"abstract":"Inflammation and infection of catheters (and polymeric medical devices in general) is a significant problem. Previous studies have demonstrated that metals with nanotubular surface features can decrease both inflammatory and bacteria functions. With this in mind, this study aimed to create polydimethylsiloxane (PDMS)/polyvinyl chloride (PVC) molds out of anodized titanium (Ti) in order to transfer this novel antibacterial surface roughness to polymers. In addition, such polymers were further tested for inflammatory and bacteria responses.","PeriodicalId":153112,"journal":{"name":"2013 39th Annual Northeast Bioengineering Conference","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128700605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
We present a work in progress of a single-channel electroencephalograph (EEG) system used in a multiple modality platform for epileptic seizure detection. This system consists of an EEG amplifier circuit that provides signal gain and filtering and a myDAQ unit that both simulates and acquires EEG signals which is controlled by a LabVIEW graphical program that performs feature extraction and signal classification. We describe the desired performance for the amplifier circuit and present preliminary measurement results and output examples from the amplifier circuit and LabVIEW program.
{"title":"Using myDAQ and LabVIEW to Develop a Single-Channel EEG for a Multi-modality Epileptic Seizure Detection Platform","authors":"David Wang, L. Khuon","doi":"10.1109/NEBEC.2013.35","DOIUrl":"https://doi.org/10.1109/NEBEC.2013.35","url":null,"abstract":"We present a work in progress of a single-channel electroencephalograph (EEG) system used in a multiple modality platform for epileptic seizure detection. This system consists of an EEG amplifier circuit that provides signal gain and filtering and a myDAQ unit that both simulates and acquires EEG signals which is controlled by a LabVIEW graphical program that performs feature extraction and signal classification. We describe the desired performance for the amplifier circuit and present preliminary measurement results and output examples from the amplifier circuit and LabVIEW program.","PeriodicalId":153112,"journal":{"name":"2013 39th Annual Northeast Bioengineering Conference","volume":"101 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127072144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tanya Wang, Josh Harvey, E. Chabot, Ying Sun, P. Burbank
The AAGILE is a device designed to reinforce a healthy daily regimen for those who choose to live independently, especially those with diminishing cognitive or physical functions. The device does so by setting goals, providing personalized interactive reminder messages, and monitoring daily activity in 5-minute increments. The purpose of this study is to minimize the overall device size and footprint of the motherboard, further develop the functions of the AAGILE and test the overall health benefits with respect to different physical and cognitive limitations and in comparison to different commercially available monitoring devices.
{"title":"Activity Analyzer for Guided Independent Living Environments (AAGILE)","authors":"Tanya Wang, Josh Harvey, E. Chabot, Ying Sun, P. Burbank","doi":"10.1109/NEBEC.2013.47","DOIUrl":"https://doi.org/10.1109/NEBEC.2013.47","url":null,"abstract":"The AAGILE is a device designed to reinforce a healthy daily regimen for those who choose to live independently, especially those with diminishing cognitive or physical functions. The device does so by setting goals, providing personalized interactive reminder messages, and monitoring daily activity in 5-minute increments. The purpose of this study is to minimize the overall device size and footprint of the motherboard, further develop the functions of the AAGILE and test the overall health benefits with respect to different physical and cognitive limitations and in comparison to different commercially available monitoring devices.","PeriodicalId":153112,"journal":{"name":"2013 39th Annual Northeast Bioengineering Conference","volume":"48 9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125732622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：