Andrea Mandragouras, Michael Napolitano, V. Fernandez, Wei Sun
The purpose of this study was to design a system capable of quantifying leaflet strain for transcatheter and surgical bioprosthetic aortic heart valves, as well as to present their 3D deformation. To demonstrate the effectiveness of the device, a transcatheter heart valve was mounted into the testing chamber, where it experienced a physiologically appropriate loading force. The three leaflets were marked in order to determine the strain of each leaflet region for precise imaging, executed by two high speed cameras. A custom LabVIEW vi was created to conduct a direct linear transformation of the images into 3D and then to calculate the strain distribution along the leaflets surface.
{"title":"Determination of Leaflet Strain Using a Novel Static Pressurization Chamber","authors":"Andrea Mandragouras, Michael Napolitano, V. Fernandez, Wei Sun","doi":"10.1109/NEBEC.2013.15","DOIUrl":"https://doi.org/10.1109/NEBEC.2013.15","url":null,"abstract":"The purpose of this study was to design a system capable of quantifying leaflet strain for transcatheter and surgical bioprosthetic aortic heart valves, as well as to present their 3D deformation. To demonstrate the effectiveness of the device, a transcatheter heart valve was mounted into the testing chamber, where it experienced a physiologically appropriate loading force. The three leaflets were marked in order to determine the strain of each leaflet region for precise imaging, executed by two high speed cameras. A custom LabVIEW vi was created to conduct a direct linear transformation of the images into 3D and then to calculate the strain distribution along the leaflets surface.","PeriodicalId":153112,"journal":{"name":"2013 39th Annual Northeast Bioengineering Conference","volume":"74 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116354488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Non-invasive fetal electrocardiogram measurements have the potential to monitor and reduce newborn clinical complications. Fetal electrocardiogram signals, however, are relatively weak and difficult to extract from the maternal electrocardiogram signal and other sources of interference. The goal of this project is to, therefore, successfully extract and process fetal electrocardiogram signals in real time from a competing background of maternal electrocardiogram signals and other forms of noise. To accomplish this goal, electrocardiogram instrumentation hardware has been designed, capable of processing multiple input data streams from electrocardiogram leads placed over the maternal abdomen. High-performance bio-potential amplification, filtering, processing, and safety issues are considered in the design. The results of this study outline a high precision and scalable electrocardiogram system for extracting fetal signal from a large background of maternal and other interfering signals.
{"title":"A Fetal Electrocardiogram Data Acquisition and Analysis System","authors":"Chris D. Samuel, A. English, Nuno Alves","doi":"10.1109/NEBEC.2013.38","DOIUrl":"https://doi.org/10.1109/NEBEC.2013.38","url":null,"abstract":"Non-invasive fetal electrocardiogram measurements have the potential to monitor and reduce newborn clinical complications. Fetal electrocardiogram signals, however, are relatively weak and difficult to extract from the maternal electrocardiogram signal and other sources of interference. The goal of this project is to, therefore, successfully extract and process fetal electrocardiogram signals in real time from a competing background of maternal electrocardiogram signals and other forms of noise. To accomplish this goal, electrocardiogram instrumentation hardware has been designed, capable of processing multiple input data streams from electrocardiogram leads placed over the maternal abdomen. High-performance bio-potential amplification, filtering, processing, and safety issues are considered in the design. The results of this study outline a high precision and scalable electrocardiogram system for extracting fetal signal from a large background of maternal and other interfering signals.","PeriodicalId":153112,"journal":{"name":"2013 39th Annual Northeast Bioengineering Conference","volume":"57 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114707050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
One of the challenges inherent with in vivo small animal imaging is the co-registration of sensitive molecular imaging techniques with high resolution anatomical imaging modalities. To overcome this challenge, we designed an imaging cassette to allow multi-modal fusion via non-concurrent registration between modalities. The imaging cassette was designed to allow for rigid registration and to be compatible with all common pre-clinical imaging modalities and with an anesthesia system. The cassette was validated by providing non-concurrent registration between fluorescence molecular tomography and micro-CT (or micro-MRI).
{"title":"Multi-modal Imaging Cassette for Small Animal Molecular Imaging","authors":"A. Hyman, Lingling Zhao, X. Intes","doi":"10.1109/NEBEC.2013.25","DOIUrl":"https://doi.org/10.1109/NEBEC.2013.25","url":null,"abstract":"One of the challenges inherent with in vivo small animal imaging is the co-registration of sensitive molecular imaging techniques with high resolution anatomical imaging modalities. To overcome this challenge, we designed an imaging cassette to allow multi-modal fusion via non-concurrent registration between modalities. The imaging cassette was designed to allow for rigid registration and to be compatible with all common pre-clinical imaging modalities and with an anesthesia system. The cassette was validated by providing non-concurrent registration between fluorescence molecular tomography and micro-CT (or micro-MRI).","PeriodicalId":153112,"journal":{"name":"2013 39th Annual Northeast Bioengineering Conference","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114863482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Saccadic eye movements induced by visual stimuli (V-saccade), auditory stimuli (A-saccade) and auditory-visual stimuli (AV-saccade) were recorded and analyzed. SMI Hi-Speed eye tracking system was used to collect human saccade data. A FORTRAN program designed to compute parameter estimates for a 1D saccadic eye movement model was used for data analysis. The controller for saccadic eye movements in response to the three different types of stimuli were compared. System parameters of agonist pulse and post-inhibitory rebound burst (PIRB) in the antagonist motoneurons that caused post-saccade phenomena were also estimated. A-saccade exhibited lower agonist pulse magnitude and longer agonist pulse duration in large saccade amplitude. Antagonist onset delay was longer in A-saccade for saccades of the same size. There was a higher incidence of dynamic overshoot in A-saccade, while more in the abducting than adducting direction.
{"title":"Parameter Estimation of Auditory Saccades and Visual Saccades","authors":"Xiu Zhai, A. Ghahari, J. Enderle","doi":"10.1109/NEBEC.2013.123","DOIUrl":"https://doi.org/10.1109/NEBEC.2013.123","url":null,"abstract":"Saccadic eye movements induced by visual stimuli (V-saccade), auditory stimuli (A-saccade) and auditory-visual stimuli (AV-saccade) were recorded and analyzed. SMI Hi-Speed eye tracking system was used to collect human saccade data. A FORTRAN program designed to compute parameter estimates for a 1D saccadic eye movement model was used for data analysis. The controller for saccadic eye movements in response to the three different types of stimuli were compared. System parameters of agonist pulse and post-inhibitory rebound burst (PIRB) in the antagonist motoneurons that caused post-saccade phenomena were also estimated. A-saccade exhibited lower agonist pulse magnitude and longer agonist pulse duration in large saccade amplitude. Antagonist onset delay was longer in A-saccade for saccades of the same size. There was a higher incidence of dynamic overshoot in A-saccade, while more in the abducting than adducting direction.","PeriodicalId":153112,"journal":{"name":"2013 39th Annual Northeast Bioengineering Conference","volume":"89 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126024533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Polhemus, Brian D. Doherty, Kevin Mackiw, Rajan Patel, M. Paliwal
Current prosthetic devices frequently offer limited function at high costs. This proof-of-concept design proposes a hybrid trans-radial prosthesis that uses gross body movements to control multiple degrees of freedom. The novel actuation system uses signals transduced from shoulder articulations to control pneumatic actuators, which power the hand.
{"title":"uGrip II: A Novel Functional Hybrid Prosthetic Hand Design","authors":"A. Polhemus, Brian D. Doherty, Kevin Mackiw, Rajan Patel, M. Paliwal","doi":"10.1109/NEBEC.2013.148","DOIUrl":"https://doi.org/10.1109/NEBEC.2013.148","url":null,"abstract":"Current prosthetic devices frequently offer limited function at high costs. This proof-of-concept design proposes a hybrid trans-radial prosthesis that uses gross body movements to control multiple degrees of freedom. The novel actuation system uses signals transduced from shoulder articulations to control pneumatic actuators, which power the hand.","PeriodicalId":153112,"journal":{"name":"2013 39th Annual Northeast Bioengineering Conference","volume":"37 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126770075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Approximately 30, 000 tibia and femur fractures require external fixation costing the medical industry $75.6 million. Monitoring fracture healing via X-rays is one of the major costs associated with post-operative recovery. Fracture Track is designed to provide a more objective method of measuring a bone's ability to tolerate full, unsupported weight and reduce the need for periodic X-rays. This non-invasive device utilizes a sensor secured to an external fixator and will ultimately reduce costs by $50.4 million annually.
{"title":"Fracture Track Bone Healing Measurement through an External Fixator","authors":"A. Zúñiga, A. Babakhanov, C. Mahajan, M. Nikish","doi":"10.1109/NEBEC.2013.97","DOIUrl":"https://doi.org/10.1109/NEBEC.2013.97","url":null,"abstract":"Approximately 30, 000 tibia and femur fractures require external fixation costing the medical industry $75.6 million. Monitoring fracture healing via X-rays is one of the major costs associated with post-operative recovery. Fracture Track is designed to provide a more objective method of measuring a bone's ability to tolerate full, unsupported weight and reduce the need for periodic X-rays. This non-invasive device utilizes a sensor secured to an external fixator and will ultimately reduce costs by $50.4 million annually.","PeriodicalId":153112,"journal":{"name":"2013 39th Annual Northeast Bioengineering Conference","volume":"46 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125149169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The original objective of this study was to quantify spasticity in a spastic subject using the Pendulum Knee Drop test. An interesting phenomenon was observed while analyzing the collected data. The neural contribution in defining or changing the set point for a passive joint movement is not well understood, therefore, the purpose of this paper is to explain the noted phenomenon according to the Equilibrium Point Hypothesis with which we can justify the changes in moments during PKD test. In passive limb movements the virtual trajectory follows the actual trajectory; in contrast for an active movement the desired trajectory precedes the actual trajectory. The present data explains passive knee movement during PKD for a CP individual and describe the changes in joint moment as function of θvt assigned by the CNS.
{"title":"The Neural Contribution to Passive Joint Movement in Individuals with Cerebral Palsy","authors":"G. Androwis, R. Foulds, Darine Jewaid","doi":"10.1109/NEBEC.2013.145","DOIUrl":"https://doi.org/10.1109/NEBEC.2013.145","url":null,"abstract":"The original objective of this study was to quantify spasticity in a spastic subject using the Pendulum Knee Drop test. An interesting phenomenon was observed while analyzing the collected data. The neural contribution in defining or changing the set point for a passive joint movement is not well understood, therefore, the purpose of this paper is to explain the noted phenomenon according to the Equilibrium Point Hypothesis with which we can justify the changes in moments during PKD test. In passive limb movements the virtual trajectory follows the actual trajectory; in contrast for an active movement the desired trajectory precedes the actual trajectory. The present data explains passive knee movement during PKD for a CP individual and describe the changes in joint moment as function of θvt assigned by the CNS.","PeriodicalId":153112,"journal":{"name":"2013 39th Annual Northeast Bioengineering Conference","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121840416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lingling Zhao, K. Abe, Margarida M Barroso, X. Intes
One of the key challenges in anti-cancer drug validation is to quantitatively discriminate in vivo non-specific receptor-independent tumor accumulation from receptor-mediated uptake into the tumor cells. To overcome this challenge, we develop a new near-infrared Förster resonance energy transfer fluorescence lifetime imaging (NIR FRET FLIM) technique. We apply herein this novel approach to monitor and characterize cellular uptake in both cancer cells and normal cells in vitro and in vivo. Our results demonstrate that NIR FRET FLIM can quantitatively distinguish receptor-bound from unbound donor in live animals with high sensitivity and high accuracy. Thus, it has a great potential for the quantitative detection of targeted delivery systems for diagnostic and therapeutic use.
{"title":"In Vivo Time-Resolved Fluorescence Imaging of a NIR FRET Probe in Live Mice","authors":"Lingling Zhao, K. Abe, Margarida M Barroso, X. Intes","doi":"10.1109/NEBEC.2013.21","DOIUrl":"https://doi.org/10.1109/NEBEC.2013.21","url":null,"abstract":"One of the key challenges in anti-cancer drug validation is to quantitatively discriminate in vivo non-specific receptor-independent tumor accumulation from receptor-mediated uptake into the tumor cells. To overcome this challenge, we develop a new near-infrared Förster resonance energy transfer fluorescence lifetime imaging (NIR FRET FLIM) technique. We apply herein this novel approach to monitor and characterize cellular uptake in both cancer cells and normal cells in vitro and in vivo. Our results demonstrate that NIR FRET FLIM can quantitatively distinguish receptor-bound from unbound donor in live animals with high sensitivity and high accuracy. Thus, it has a great potential for the quantitative detection of targeted delivery systems for diagnostic and therapeutic use.","PeriodicalId":153112,"journal":{"name":"2013 39th Annual Northeast Bioengineering Conference","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121957043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A process was designed to decrease the amount of time required to align the causeways and Mobile Acute Care Hospital trucks in order to protect personnel and patients.
设计了一个流程，以减少调整堤道和流动急症护理医院卡车所需的时间，以保护人员和患者。
{"title":"Alignment in MACH Systems (AIMS)","authors":"H. Allen, C. Coutros, K. Coyle, C. Strom","doi":"10.1109/NEBEC.2013.48","DOIUrl":"https://doi.org/10.1109/NEBEC.2013.48","url":null,"abstract":"A process was designed to decrease the amount of time required to align the causeways and Mobile Acute Care Hospital trucks in order to protect personnel and patients.","PeriodicalId":153112,"journal":{"name":"2013 39th Annual Northeast Bioengineering Conference","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122826131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lauren J Jablonowski, Averie Palovcak, M. Wheatley
This research aims to develop an injectable polymer-based, platform to enable minimally-invasive targeted delivery of bioactive nano particles. Studies have shown polymer-stabilized gas microbubbles to be effective in enhancing an ultrasound image, especially those involving cancerous tumors. These contrast agents can serve a dual purpose when designed to include a specific ligand conjugated to the surface for targeting and a drug encapsulated in the shell. Research is underway to harness these techniques in the fight against cancer. Tumor necrosis factor related apoptosis-inducing ligand (TRAIL) is a protein that not only binds to cell death receptors (DR4 and DR5) on cancerous cells for targeting, but this binding also promotes apoptosis in the targeted cell. Healthy cells have decoy receptors that compete for binding. Our hypothesis is that intravenously injected TRAIL-conjugated microbubbles, when exposed to ultrasound (US), will burst to form nanoshards (n-Sh) which will transport the TRAIL to cancer cell receptors, where binding initiates apoptosis.
本研究旨在开发一种基于聚合物的可注射平台，以实现生物活性纳米颗粒的微创靶向递送。研究表明，聚合物稳定的气体微泡在增强超声图像方面是有效的，特别是那些涉及癌症肿瘤的超声图像。这些造影剂可用于双重目的，当设计包括一个特定的配体缀合到表面用于靶向和药物封装在壳。利用这些技术对抗癌症的研究正在进行中。肿瘤坏死因子相关凋亡诱导配体(Tumor necrosis factor related apoptosis-inducing ligand, TRAIL)是一种蛋白质，它不仅与癌细胞上的细胞死亡受体(DR4和DR5)结合靶向，而且这种结合还能促进被靶向细胞的凋亡。健康细胞具有竞争结合的诱饵受体。我们的假设是，静脉注射TRAIL偶联微泡，当暴露在超声波(US)下时，会破裂形成纳米碎片(n-Sh)，将TRAIL运输到癌细胞受体，在那里结合引发细胞凋亡。
{"title":"Induction of Apoptosis by Targeted Ultrasound Contrast Agents in Cancer Therapy","authors":"Lauren J Jablonowski, Averie Palovcak, M. Wheatley","doi":"10.1109/NEBEC.2013.101","DOIUrl":"https://doi.org/10.1109/NEBEC.2013.101","url":null,"abstract":"This research aims to develop an injectable polymer-based, platform to enable minimally-invasive targeted delivery of bioactive nano particles. Studies have shown polymer-stabilized gas microbubbles to be effective in enhancing an ultrasound image, especially those involving cancerous tumors. These contrast agents can serve a dual purpose when designed to include a specific ligand conjugated to the surface for targeting and a drug encapsulated in the shell. Research is underway to harness these techniques in the fight against cancer. Tumor necrosis factor related apoptosis-inducing ligand (TRAIL) is a protein that not only binds to cell death receptors (DR4 and DR5) on cancerous cells for targeting, but this binding also promotes apoptosis in the targeted cell. Healthy cells have decoy receptors that compete for binding. Our hypothesis is that intravenously injected TRAIL-conjugated microbubbles, when exposed to ultrasound (US), will burst to form nanoshards (n-Sh) which will transport the TRAIL to cancer cell receptors, where binding initiates apoptosis.","PeriodicalId":153112,"journal":{"name":"2013 39th Annual Northeast Bioengineering Conference","volume":"74 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128296338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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