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Difficulties in diagnosis of carcinoma of the tongue 舌癌诊断的困难
Pub Date : 2020-01-01 DOI: 10.15584/ejcem.2019.4.14
D. Panda, Bhubaneswar Odisha India Acharya Vihar
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引用次数: 0
Effects of sensory integration therapy in a 7-year old child with epilepsy following craniocerebral trauma – a case study 感觉统合治疗对7岁儿童颅脑外伤后癫痫的疗效研究
Pub Date : 2020-01-01 DOI: 10.15584/ejcem.2020.1.15
Maria Widelak, A. Wolan-Nieroda, J. Podgórska-Bednarz, A. Guzik
Introduction. Post-traumatic epilepsy develops as a complication of a serious craniocerebral trauma, frequently an open head injury, resulting in neurological impairments. Aim. The study was designed to discuss problems associated with sensory integration dysfunction observed in a seven-year old girl with epilepsy which occurred as a result of craniocerebral injury. Description of the case. The case study is based on information gained from the girl’s medical records, an interview with her guardians and a sensory function questionnaire. Additional examinations assessed the girl’s balance control, and her functional performance according to Barthel scale. The girl received a three-week sensory integration therapy which included exercise involving tactile, vestibular and proprioceptive stimulation, as well as balance exercises and self-care training. Conclusions. In this particular case, application of sensory integration therapy produced beneficial results. The findings show improvement in balance, coordination as well as self-care.
介绍。创伤后癫痫是严重颅脑创伤(通常是开放性头部损伤)的并发症,可导致神经损伤。的目标。本研究旨在探讨一名七岁癫痫女孩因颅脑损伤而出现的感觉统合功能障碍相关问题。案件描述。案例研究基于从女孩的医疗记录、对其监护人的访谈和感觉功能问卷中获得的信息。额外的检查评估了女孩的平衡控制,并根据Barthel量表评估了她的功能表现。该女孩接受了为期三周的感觉统合治疗,包括触觉、前庭和本体感觉刺激,以及平衡练习和自我保健训练。结论。在这种特殊情况下,感觉统合疗法的应用产生了有益的结果。研究结果显示,他们在平衡、协调和自我照顾方面都有所改善。
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引用次数: 0
Applicability of Cardiopulmonary Exercise Test 心肺运动试验的适用性
Pub Date : 2020-01-01 DOI: 10.15584/ejcem.2019.4.11
Filip Wołoszyn, P. Pańczyszyn-Trzewik, Seweryn Ziajor, Aleksandra Misygar, Artur Bednarski, Oskar Kwiatkowski, M. Sowa-Kućma
Introduction. Cardiopulmonary Exercise Testing (CPET) test is a test that allows an integrated response to the physical effort of the cardiovascular system, respiratory system, nervous system, skeletal muscles and metabolism. The growing awareness of better correlation between health condition and exercise tolerance than with resting measurements is the key importance. The range of clinical applications is expanding to assess impairment of physical capacity with an unclear cause and to objectively determine functional capacity. Aim. The aim of this review was to discuss the applicability of cardiopulmonary exercise test in diverse branches of clinical and
介绍。心肺运动测试(CPET)测试是一项测试,允许对心血管系统,呼吸系统,神经系统,骨骼肌和新陈代谢的身体努力做出综合反应。越来越多的人意识到健康状况和运动耐受性之间的关系比静息测量之间的关系更好,这一点至关重要。临床应用的范围正在扩大,以评估残疾的身体能力与不明确的原因,客观地确定功能能力。的目标。本综述的目的是讨论心肺运动试验在临床和临床不同分支的适用性
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引用次数: 1
Seroprevalence of Toxoplasmosis among Human Immunodeficiency Virus infected pregnant women in Abuja Teaching Hospital, Nigeria 尼日利亚阿布贾教学医院感染人类免疫缺陷病毒的孕妇中弓形虫病的血清患病率
Pub Date : 2020-01-01 DOI: 10.15584/ejcem.2020.3.3
M. Zakari, A. Isah, R. Offiong, T. Yunusa, I. Abdullahi
Introduction. Toxoplasmosis is a neglected parasitic infection that has economic and epidemiological significance. Data on toxoplasmosis seroprevalence among Human Immunodeficiency Virus (HIV) infected pregnant women may be of obstetric and neonatal concern. Aim. The study was designed to determine the seroprevalence of Toxoplasmosis and associated risk factors in HIV-positive pregnant women attending the University of Abuja Teaching Hospital, Abuja, Northcentral Nigeria. Material and methods. This was a hospital-based cross-sectional study. A total of 160 HIV seropositive pregnant women were recruited. Blood samples were collected and tested for anti-T. gondii IgM and IgG using Enzyme Linked Immunosorbent Assay (ELISA). Structured questionnaires were used to collate the sociodemographic variables of participants. Results. Out of the 160 of HIV seropositive pregnant women, the seroprevalence anti-T. gondii IgG and IgM were 29.4% and 4.4%, respectively. There was no significant association between anti-T. gondii and all sociodemographic variables studied
介绍。弓形虫病是一种被忽视的寄生虫感染,具有经济和流行病学意义。人类免疫缺陷病毒(HIV)感染孕妇中弓形虫病血清患病率的数据可能是产科和新生儿关注的问题。的目标。该研究旨在确定在尼日利亚中北部阿布贾的阿布贾大学教学医院就诊的艾滋病毒阳性孕妇中弓形虫病的血清患病率和相关危险因素。材料和方法。这是一项基于医院的横断面研究。总共招募了160名艾滋病毒血清阳性的孕妇。采集血样并检测抗t抗体。采用酶联免疫吸附法(ELISA)检测弓形虫IgM和IgG。采用结构化问卷对参与者的社会人口学变量进行整理。结果。在160例HIV血清阳性的孕妇中,血清抗t抗体的流行率。弓形虫IgG和IgM分别为29.4%和4.4%。抗t抗体与抗t抗体之间无显著相关性。弓形虫和所有社会人口变量的研究
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引用次数: 1
Cognitive behavioural therapy and core stabilization exercise on pain-related disability and psychological status in patients with non-specific chronic low back pain 认知行为疗法和核心稳定运动对非特异性慢性腰痛患者疼痛相关残疾和心理状态的影响
Pub Date : 2020-01-01 DOI: 10.15584/ejcem.2020.3.6
A. Akodu, T. Ogunbiyi, O. Fapojuwo
Introduction. Exercises have been shown to relieve symptoms in non-specific chronic low back pain (NSCLBP) patients. Aim. This study compared the effects of cognitive behavioural therapy (CBT) and core stabilization exercises (CSE) on pain-related disability, psychological status and sleep disturbance in patients with NSCLBP. Material and methods. This randomized controlled trial involved a total of thirty-seven (37) participants. They were randomly allotted into three groups [CBT (11), CSE (14) and control (12)]. The intervention was done once per week for duration of 60 minutes for the CBT group, 30 minutes for CSE group and 10 minutes for the control group twice per week for 8 consecutive weeks. Assessment of outcome was done at baseline, 4 weeks and 8 weeks. Data were analyzed using statistical package for social science version 25 at alpha level of less than 0.05. Results. The results of this study showed that there was significant improvement in the level of pain-related disability (p= 0.001), level of anxiety (p =0.001), depression (p = 0.01, p = 0.001, p =0.001) and sleep disturbance (p = 0.001) in all the groups (CBT, CSE, control) post treatment. Conclusion. CBT and CSE are both effective in the treatment of pain-related disability, sleep disturbance, and psychological status of NSCLBP patients.
介绍。运动已被证明可以缓解非特异性慢性腰痛(NSCLBP)患者的症状。的目标。本研究比较了认知行为疗法(CBT)和核心稳定练习(CSE)对非小细胞bp患者疼痛相关残疾、心理状态和睡眠障碍的影响。材料和方法。这项随机对照试验共涉及37名参与者。随机分为CBT组(11例)、CSE组(14例)和对照组(12例)。干预每周进行一次,CBT组持续60分钟,CSE组30分钟,对照组10分钟,每周两次,连续8周。在基线、4周和8周进行结果评估。数据采用社会科学25版统计软件包进行分析,alpha水平小于0.05。结果。本研究结果显示,CBT组、CSE组、对照组治疗后疼痛相关残疾水平(p= 0.001)、焦虑水平(p= 0.001)、抑郁水平(p= 0.01, p= 0.001, p= 0.001)和睡眠障碍水平(p= 0.001)均有显著改善。结论。CBT和CSE在治疗NSCLBP患者的疼痛相关残疾、睡眠障碍和心理状态方面均有效。
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引用次数: 2
Laparoscopic partial cystectomy for bladder endometriosis – case report 腹腔镜膀胱部分切除术治疗膀胱子宫内膜异位症1例报告
Pub Date : 2020-01-01 DOI: 10.15584/ejcem.2019.4.13
D. Godlewski, Patryk Pszczółkowski, T. Góra, Łukasz Futyma, T. Fedus, D. Aebisher
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引用次数: 0
Genetic study of a family with affected members with Waardenburg syndrome type 4 without Hirschsprung disease 无巨结肠疾病的Waardenburg综合征4型患者家族遗传研究
Pub Date : 2020-01-01 DOI: 10.15584/ejcem.2020.2.3
Mitra Sabetghadam Moghadam, Sima Rayat, S. Morovvati
Introduction. Waardenburg syndrome (WS) is an autosomally inherited disorder with the most common state compounding pigmentary abnormality and sensorineural deafness. The rarest type of the disease is WS4 with the general characteristic discriminated from other types by the attendance of Hirschsprung disease (HD). Among the several genes, one of the causative genes in WS4 is endothelin 3 (EDN3) with both autosomal recessive and dominant inheritance. Aim. The intention of the present study is to report a pathogenic mutation as the genetic cause of WS in an Iranian family with four patients without any segregation criteria for the type of the disease. Material and methods. In order to detect of causing gene or genes related to the disease, Whole exome sequencing (WES) technique in proband’s sample was done. To confirm the detected mutation in proband and some family members with or without the disease direct sequencing of END3 gene was performed using Sanger method. Results. Pedigree analysis suggested segregation of WS as an autosomal recessive trait in the family. WES analysis suggested a gene (EDN3) related to WS type 4B. DNA sequencing confirmed a pathogenic missense mutation c.293C>T, p.T98M in EDN3 gene in all of the four patients. Conclusion. Determination of WS can usually be missed owing to the lack of some attributes in every sufferer and also conventional clinical variance, in spite of several affected members in a single family. So, Genetic counseling is pivotal for families with multiple members influenced. We detected c.293C>T, p.T98K mutation in EDN3 gene as a pathogenic variant which has been known as a likely pathogenic state in the American College of Medical Genetics and Genomics (ACMG) guidelines, despite one prior report. It will be helpful in genetic diagnosis of affected persons and increases the mutation spectrum of EDN3 gene.
介绍。Waardenburg综合征(WS)是一种常遗传性疾病,最常见的状态是色素异常和感音神经性耳聋。该疾病最罕见的类型是WS4,其一般特征是与其他类型相区别的巨结肠病(HD)的出现。在这些基因中,内皮素3 (EDN3)是WS4的致病基因之一,具有常染色体隐性遗传和显性遗传。的目标。本研究的目的是报道一个伊朗家庭的致病突变作为WS的遗传原因,该家庭有4名患者,没有任何疾病类型的分离标准。材料和方法。为了检测该病的致病基因或相关基因,对先证者样本进行了全外显子组测序(WES)技术。采用Sanger法对END3基因进行直接测序,以证实先证者及部分患病或未患病家庭成员中检测到的突变。结果。家系分析表明WS在家族中是常染色体隐性遗传。WES分析发现一个与WS 4B型相关的基因EDN3。DNA测序证实4例患者均存在EDN3基因c.293C>T, p.T98M致病性错义突变。结论。尽管一个家族中有几个患病成员,但由于每位患者缺乏某些特征,以及常规的临床差异,WS的诊断通常会被遗漏。因此,遗传咨询对于有多个受影响成员的家庭至关重要。我们检测到EDN3基因中的c.293C>T, p.T98K突变是一种致病变异,尽管之前有一篇报道,但在美国医学遗传学和基因组学学院(ACMG)指南中被认为是一种可能的致病状态。这将有助于患者的遗传诊断,并增加EDN3基因的突变谱。
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引用次数: 0
Gastro-esophageal reflux and obstructive sleep apnea – is there a link? 胃食管反流和阻塞性睡眠呼吸暂停——有联系吗?
Pub Date : 2020-01-01 DOI: 10.15584/ejcem.2020.2.5
Piotr Pardak, A. Pękala, S. Jarmakiewicz, R. Filip
Introduction. The epidemic of obesity has led to an increase in the occurrence of obstructive sleep apnea and gastro-esophageal reflux disease. The mechanism of development of gastro-esophageal reflux disease is multifactorial, and studies conducted in the last decade have shed new light on the causes of its development in patients with sleep apnea and obesity. Aim. The aim of the study was to discuss the mechanism of development of gastro-esophageal reflux disease is multifactorial, and studies conducted in the last decade have shed new light on the causes of its development in patients with sleep apnea and obesity and the dysfunction of the lower esophageal sphincter. Material and methods. An analysis of literature regarding gastro-esophageal reflux and obstructive sleep apnea. Results. In obstructive sleep apnea and obesity, high levels of cytokines and insulin resistance are observed, resulting in disorders in the levels of ghrelin – a hormone responsible for normal gastrointestinal motility. Conclusion. The effect of deviations in the ghrelin profile on the development of gastro-esophageal reflux disease remains a matter for further research.
介绍。肥胖的流行导致阻塞性睡眠呼吸暂停和胃食管反流病的发生率增加。胃食管反流病的发病机制是多因素的,近十年来的研究对睡眠呼吸暂停和肥胖患者的发病原因有了新的认识。的目标。本研究的目的是探讨胃食管反流病的发展机制是多因素的,近十年来的研究对睡眠呼吸暂停和肥胖患者的胃食管下括约肌功能障碍的发展原因有了新的认识。材料和方法。胃食管反流与阻塞性睡眠呼吸暂停的文献分析。结果。在阻塞性睡眠呼吸暂停和肥胖中,观察到高水平的细胞因子和胰岛素抵抗,导致胃饥饿素水平紊乱——胃饥饿素是一种负责正常胃肠运动的激素。结论。胃饥饿素谱偏离对胃食管反流病发展的影响仍有待进一步研究。
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引用次数: 0
External ophthalmomyiasis by sheep botfly – a report from Sirmaur hills 羊蝇引起的外眼病——一份来自锡马尔山的报告
Pub Date : 2020-01-01 DOI: 10.15584/ejcem.2020.1.14
A. Chauhan, N. Gautam
Introduction. Myiasis is caused by larvae of flies infesting animal or human tissues and organs. Aim. In this report we present 2 cases of external ophthalmomyiasis by sheep botfly. Description of the cases. We report a case of two patients who presented with a history of foreign body sensation in the left and the right eye respectively. Slit lamp examination revealed larvae of Oestrus ovis (sheep botfly). In both cases, there was no contact history with sheep or goats. Signs of conjunctival inflammation and corneal involvement were absent in both cases. In most of the previous reports, corneal and conjunctival inflammation was present. Conclusion. Treatment for external ophthalmomyiasis is based on larvae removal and application of topical antibiotics and steroids.
介绍。蝇蛆病是由蝇的幼虫侵入动物或人体的组织和器官引起的。的目标。本文报告2例由羊蝇引起的外眼病。案例描述。我们报告了两例分别有左眼和右眼异物感病史的患者。裂隙灯检查发现羊蝇幼虫。在这两例病例中,都没有与绵羊或山羊的接触史。两例均无结膜炎症及角膜受累征象。在大多数先前的报告中,存在角膜和结膜炎症。结论。治疗外眼病是基于幼虫去除和应用局部抗生素和类固醇。
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引用次数: 0
Treating kidney cancer – a review 治疗肾癌——综述
Pub Date : 2020-01-01 DOI: 10.15584/ejcem.2020.1.8
Piotr Przyczyna, D. Aebisher, D. Bartusik-Aebisher, E. Kaznowska
Introduction. Kidney cancer in the structure of registered cases was in 6th place in men and 8th in women. Aim. Understanding the molecular biology of renal cell carcinoma has made it possible to produce new diagnostic methods. Material and methods. This review was performed according to a systematic literature search. Results. Minimally invasive techniques seem to have a bright future in kidney cancer. However, they still require many clinical trials before they enter the general clinical use. Conclusion. Photodynamic therapy, thanks to research conducted in kidney cancer, will find application in cancer of other organs.
介绍。在登记病例的结构中,肾癌在男性中排名第六,在女性中排名第八。的目标。了解肾细胞癌的分子生物学,使产生新的诊断方法成为可能。材料和方法。本综述是根据系统的文献检索进行的。结果。微创技术在肾癌治疗中有着光明的前景。然而,在进入一般临床应用之前,它们仍需要进行大量的临床试验。结论。由于对肾癌的研究,光动力疗法将在其他器官的癌症中得到应用。
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引用次数: 0
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临床和实验医学杂志
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