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临床和实验医学杂志最新文献

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Rating of the effectiveness of cleaning and disinfection procedures in a mass catering establishment 对大众饮食业的清洁及消毒程序的有效性进行评级
Pub Date : 2020-01-01 DOI: 10.15584/ejcem.2019.4.6
A. Sidor, Patrycja Preizner, Provincial Sanitary, Rzeszow Poland Epidemiological Station in Rzeszow
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引用次数: 0
The larynx cancer in vitro study by MRI relaxtion time of water 水的MRI弛豫时间对喉癌的体外研究
Pub Date : 2020-01-01 DOI: 10.15584/ejcem.2020.3.5
W. Domka, Ł. Ożóg, D. Bartusik-Aebisher, D. Aebisher
Introduction. Squamous cell carcinoma (SCC) of the larynx accounts for a significant percentage of all head and neck cancers. Aim. In this paper we determine the differences in magnetic resonance relaxation time (MRI) of water in cancerous and healthy larynx tissues. Material and methods. This study is aimed on T2 MRI modalities for monitoring morphology of larynx tissue. Results. Our results showed that T2 MRI relaxation time measured in larynx tissue can be used to assess early cancer condition of larynx tissues. The changes of T2 MRI correspond to tumor growth within normal tissue. Conclusion. The study showed potential of MRI for the non-invasive monitoring of larynx condition.
介绍。喉部鳞状细胞癌(SCC)占所有头颈部癌症的很大比例。的目标。本文测定了癌变喉组织和健康喉组织中水的磁共振弛豫时间(MRI)的差异。材料和方法。本研究旨在用T2 MRI模式监测喉部组织形态。结果。我们的研究结果表明,喉部组织的T2 MRI弛豫时间可用于评估喉部组织的早期癌变情况。T2 MRI的变化与正常组织内肿瘤的生长相对应。结论。该研究显示了MRI在无创监测喉部状况方面的潜力。
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引用次数: 0
Primary pure squamous cell carcinoma of the gall bladder – a case report of rare and aggressive entity with adverse prognosis 原发性纯胆囊鳞状细胞癌-罕见侵袭性肿瘤1例,预后不良
Pub Date : 2020-01-01 DOI: 10.15584/ejcem.2020.1.13
Mona Bargotya, A. Mehta, Payel Das, A. Sachan
Introduction. The most common malignancy of the biliary tract is gall bladder carcinoma and the main subtype according to the histological classification is Adenocarcinoma. Pure squamous cell carcinoma of the gall bladder is very rare entity accounting for only 1.1-3.7% of the gall bladder carcinomas. It is highly malignant with poor prognosis due to high proliferative rate and local invasiveness to the adjacent organs. The patients are usually diagnosed at an advanced stage with a bulky tumor owing to its aggressive behavior. Aim. In this paper, we describe a female patient with primary pure squamous cell carcinoma of the gall bladder. Description of the case. A 42-year old female patient presented with chief complaints of pain in abdomen associated with nausea and vomiting and gradually progressive jaundice since 02 months. Contrast Enhancing Computed Tomography (CECT) abdomen showed an enhancing mass lesion in gall bladder involving adjacent organs for which she underwent extended cholecystectomy with pancreaticoduodenectomy. Conclusion. Diagnosis as well as the management of this exceptionally rare type of tumour is undoubtedly challenging because of non-specific clinical as well as imaging findings. This case report is an attempt to add to the literary evidence for better pathological as well as clinical understanding of this rare and aggressive entity thereby providing additional material for the early diagnosis as well as the development of effective targeted therapies which will certainly help in increasing the lifespan of these patients.
介绍。胆道最常见的恶性肿瘤是胆囊癌,根据组织学分类,主要亚型为腺癌。单纯的胆囊鳞状细胞癌是一种非常罕见的肿瘤,仅占所有胆囊肿瘤的1.1-3.7%。由于高增殖率和局部侵犯邻近器官,它是高度恶性的,预后差。由于肿瘤具有侵袭性,患者通常在肿瘤晚期被诊断出来。的目标。在本文中,我们描述了一个女性患者原发性纯鳞状细胞癌的胆囊。案件描述。女,42岁,主诉腹部疼痛伴恶心呕吐,黄疸渐进性,02个月。腹部造影增强计算机断层扫描(CECT)显示胆囊肿块强化病变累及邻近器官,为此患者行胰十二指肠切除术及胆囊切除术。结论。由于非特异性的临床和影像学表现,这种异常罕见的肿瘤的诊断和治疗无疑具有挑战性。本病例报告试图增加文献证据,以更好地了解这种罕见的侵袭性实体的病理和临床,从而为早期诊断和有效靶向治疗的发展提供额外的材料,这将有助于延长这些患者的寿命。
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引用次数: 0
Glycosylation of immune system proteins and its role in autoimmune diseases and cancer 免疫系统蛋白的糖基化及其在自身免疫性疾病和癌症中的作用
Pub Date : 2020-01-01 DOI: 10.15584/ejcem.2020.1.7
Anna Trzyna, J. Tabarkiewicz, A. Mazur
Introduction. Structural glycans have great biological significance and are involved in signaling and cell communication of the immune system. They are attached to proteins and lipids in an enzymatic process called glycosylation where glycosyltransferase and glycosidases bind sugar residues and lead to the formation of bioconjugates. Aim. In this paper we describe the importance of glycosylation in the immune system and its changes in diseases. Material and methods. This review was performed according to systematic literature search of major bibliographic databases. Results. Proper glycosylation ensures the functioning of the organism, however, defects in structural glycans of immune system changes their properties and can lead to disorders and further to autoimmune diseases. It has been also proven that glycosylation of autoimmune system is changed during cancer. In this paper we described types of structural glycans, significance of glycosylation of selected components of the immune system and its modifications in disorders. Conclusions. Knowledge about changes in the glycosylation in diseases is the key to understanding the processes of autoimmune diseases and may allow the development of new treatments in the future.
介绍。结构聚糖具有重要的生物学意义,参与免疫系统的信号和细胞通讯。它们通过糖基化的酶促过程附着在蛋白质和脂质上,其中糖基转移酶和糖苷酶结合糖残基并导致生物偶联物的形成。的目标。本文介绍了糖基化在免疫系统中的重要性及其在疾病中的变化。材料和方法。本综述是根据主要书目数据库的系统文献检索进行的。结果。适当的糖基化保证了机体的功能,然而,免疫系统结构聚糖的缺陷改变了它们的性质,并可能导致紊乱,进而导致自身免疫性疾病。研究还证实,自身免疫系统的糖基化在癌症期间发生改变。在本文中,我们描述了结构聚糖的类型,糖基化的免疫系统选择组分的意义及其在疾病中的修饰。结论。了解疾病中糖基化的变化是了解自身免疫性疾病过程的关键,并可能在未来开发新的治疗方法。
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引用次数: 0
Lycopene activity on lung and kidney cancer cells by T2 relaxation time 1H Magnetic Resonance Imaging in vitro 体外T2弛豫时间1H磁共振成像法观察番茄红素对肺癌和肾癌细胞的活性
Pub Date : 2020-01-01 DOI: 10.15584/ejcem.2020.1.1
K. Pogoda, Maria Pucka, J. Tabarkiewicz, Zuzanna Bober, D. Aebisher, Sabina Galiniak, D. Bartusik-Aebisher
Introduction. The paper presents the results of a study of cell cultures of lung cancer and kidney cancer using lycopene performed using clinical magnetic resonance imaging. Aim. The aim of the study was to evaluate lycopene activity on tumor cell cultures. Material and methods. For this purpose, MR tests were performed using the technique of determining transverse relaxation. Results. Described here studies demonstrated that lycopene may inhibit the growth of A549 and ACHN cell lines. Conclusion. We determine changes in spin lattice relaxavity T2 to monitor treatment of lung cancer cell line A549 and kidney cancer cell line ACHN cells treatment with lycopene.
介绍。本文介绍了使用番茄红素对肺癌和肾癌细胞培养进行临床磁共振成像的研究结果。的目标。本研究的目的是评价番茄红素对肿瘤细胞培养的活性。材料和方法。为此,使用确定横向弛豫的技术进行了磁共振测试。结果。本文研究表明,番茄红素可能抑制A549和ACHN细胞系的生长。结论。我们通过测定自旋晶格弛豫T2的变化来监测番茄红素对肺癌细胞系A549和肾癌细胞系ACHN细胞的治疗作用。
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引用次数: 0
Cytotoxic and anticancer activity of Moringa oleifera 辣木的细胞毒性和抗癌活性
Pub Date : 2020-01-01 DOI: 10.15584/ejcem.2020.3.9
Kinga Szlachetka, Paulina Kut, A. Stępień
Introduction. Given its very strong antioxidant properties, Moringa oleifera is particularly noteworthy among medicinal plants. The high contents antioxidants in the M. oleifera determining her antioxidant activities deciding for very important anticancer properties. Aim. The aim of the paper is to provide an overview of the cytotoxic and anticancer activity of Moringa oleifera. Material and methods. This review was performed based systematic analysis of literature. Analysis of the literature. The results of scientific research conducted in vitro indicate that extracts from Moringa oleifera significantly affect the development of human cancer cells such as myeloma, leukemia, cervix, breast, colon, lung, liver, neuroblastoma, pancreas, colorectal, epidermoid, oral, ovarian, muscular, prostate, skin. Conclusion. This indicates Moringa oleifera as that they may be used as a therapeutic agent to support oncological therapies.
介绍。辣木具有很强的抗氧化性能,在药用植物中尤其值得注意。油葵中抗氧化剂的高含量决定了其抗氧化活性,从而决定了油葵具有非常重要的抗癌特性。的目标。本文就辣木的细胞毒和抗癌作用作一综述。材料和方法。本综述是在系统分析文献的基础上进行的。文献分析。体外科学研究结果表明,辣木提取物对骨髓瘤、白血病、宫颈、乳腺、结肠、肺、肝、神经母细胞瘤、胰腺、结肠、表皮样细胞、口腔、卵巢、肌肉、前列腺、皮肤等人类癌细胞的发育有显著影响。结论。这表明辣木可以作为一种治疗药物来支持肿瘤治疗。
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引用次数: 4
Bladder leiomyoma: diagnostics, laparoscopy, and treatment 膀胱平滑肌瘤:诊断、腹腔镜检查和治疗
Pub Date : 2020-01-01 DOI: 10.15584/ejcem.2020.3.13
D. Godlewski, Patryk Pszczółkowski, T. Fedus, D. Aebisher
Introduction. Leiomyosarcoma is the most common benign tumor of the bladder. However, it is only a small percentage of all proliferative changes of this organ. Aim. Presentation based on two clinical cases of diagnostics and surgical treatment from laparoscopic access of bladder leio-
介绍。平滑肌肉瘤是膀胱最常见的良性肿瘤。然而,这只是该器官所有增生性变化的一小部分。的目标。本文介绍腹腔镜下膀胱输导通路诊断及手术治疗两例
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引用次数: 0
Hyalinising clear cell carcinoma of salivary gland: a case report 涎腺透明细胞癌1例
Pub Date : 2020-01-01 DOI: 10.15584/ejcem.2020.2.8
M. Osuchowski, D. Bartusik-Aebisher, E. Kaznowska, D. Aebisher
Introduction. Clear cell carcinoma, not otherwise specified/hyalinising clear cell carcinoma of the salivary gland (HCCC) is a malignancy that arises in minor salivary glands. It rarely leads to distant metastases or cancer-related death but has the potential for recurrence and focal metastases. Aim. A case is reported. Description of the case. A 72 years old female patient has reported to the Clinic of Otolaryngology with a tongue lesion. The patient had no history of malignancy. The lymph node has been surgically removed for further examination. Cords and nests of clear cells and cells with eosinophilic cytoplasm in a hyalinized stroma were identified within the lymph node. After the diagnosis the patient has been transferred to another Oncology Hospital for further treatment. Conclusion. The diagnosis of clear cell carcinoma may be challenging because many of it‘s features frequently overlap with other salivary gland lesions.
介绍。涎腺透明细胞癌(HCCC)是一种发生在小唾液腺的恶性肿瘤。它很少导致远处转移或癌症相关死亡,但有复发和局灶转移的可能性。的目标。报告一例。案件描述。一位72岁的女性患者因舌部病变向耳鼻喉科诊所报告。患者无恶性肿瘤病史。淋巴结已被手术切除以作进一步检查。淋巴结内可见透明细胞的索状和巢状,以及透明基质中嗜酸性细胞质的细胞。确诊后,患者转到另一家肿瘤医院接受进一步治疗。结论。透明细胞癌的诊断可能具有挑战性,因为它的许多特征经常与其他唾液腺病变重叠。
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引用次数: 0
Triple thyroglossal duct cysts in an adult: a rare case report and review of literature 成人三甲状舌管囊肿:罕见病例报告及文献复习
Pub Date : 2020-01-01 DOI: 10.15584/ejcem.2020.2.7
A. Bhardwaj, K. Gupta, M. Malhotra, M. Priya, M. Verma
Introduction. Thyroglossal duct cyst (TDC) is the most common cause of congenital neck mass. These can present anywhere from foramen caecum to mediastinum. Usually presents as a solitary cyst, the double thyroglossal cyst is very rare and a triple thyroglossal cyst has never been reported. Aim. Herein, we report an atypical case of triple thyroglossal cyst, at levels of hyoid, thyrohyoid membrane and thyroid isthmus managed surgically without any complication. Description of the case. We are presenting case of a 48-year-old female who presented to us with the complaint of anterior neck swelling since birth. On work up it was diagnosed as a case of the thyroglossal duct cyst and was intraoperatively found to have 3 distinct cystic swellings connected to a common stalk lying beneath the hyoid. It was successfully treated by modified Sistrunk’s procedure. There was no evidence of recurrence on follow up for 6 months. Considering atypical presentations, there are 9 cases reported with the double thyroglossal duct cyst, TDC within the thyroid gland and sublingual TDC. Such presentations make the diagnosis more challenging, leading to improper treatment. Conclusion. We are presenting this case as there is no case reported in English literature with a triple thyroglossal duct cyst. An awareness that thyroglossal cyst can present as multiple cysts is important for clinician in order to perform correct surgical management and to avoid the most feared complication of recurrence.
介绍。甲状舌管囊肿(TDC)是先天性颈部肿块最常见的原因。它们可以出现在盲肠孔到纵隔的任何地方。双甲状舌囊肿通常表现为单发囊肿,非常罕见,三甲状舌囊肿从未报道过。的目标。在此,我们报告一例不典型的三甲状舌囊肿,在舌骨,甲状腺舌骨膜和甲状腺峡的水平手术处理,没有任何并发症。案件描述。我们提出的情况下,一个48岁的女性谁提出了我们的投诉前颈部肿胀,因为出生。检查时被诊断为甲状舌管囊肿术中发现有3个明显的囊性肿胀与舌骨下面的一个共同柄相连。经改良的西斯特伦克手术成功治疗。随访6个月无复发迹象。考虑到不典型的表现,我们报告了9例双甲状腺舌管囊肿、甲状腺内TDC和舌下TDC。这样的表现使诊断更具挑战性,导致治疗不当。结论。我们之所以提出这个病例,是因为在英语文献中没有报道过三重甲状舌管囊肿。认识到甲状舌囊肿可以表现为多发性囊肿,对临床医生进行正确的手术治疗和避免最可怕的并发症复发是很重要的。
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引用次数: 2
The Impact of ‘Stay At Home’ Orders on Emergency Room Admissions “待在家里”命令对急诊室入院人数的影响
Pub Date : 2020-01-01 DOI: 10.15584/ejcem.2020.3.2
A. Koçak, S. Doğruyol, I. Akbas, B. Kerget, Sultan Tuna Akgol Gur, Z. Çakır
Introduction. The 2019-novel-coronavirus (2019-nCoV) outbreak has become a common problem for the whole world. Aim. To investigate the impact of the 2019-nCoV pandemic period in our country on emergency room admissions. Materials and methods. The study was designed as a retrospective cohort. The first case of pneumonia infected with nCoV in our country was diagnosed on March 11, 2020. Considering the date of March 11, 2020, emergency room admissions for two periods of 7 days were investigated, pre-COVID-19 and COVID19. Demographic data, admission diagnosis, vital findings, stay times in emergency room, terminations and emergency department mortality examined. A group of ‘geriatric’ patient populations were created to examine the admission characteristics of patients aged-65 and over. Results. The 3466 patients included in the study. The average number of daily admissions was significantly higher in the pre-COVID-19 period (350.4 ± 54.5), compared to the COVID-19 period (144.7 ± 20.2, p=0001). While the proportion of cardiac-caused admissions increased during the COVID period, the proportion of gastrointestinal-induced admissions decreased (p<0001). Hospitalization rates for both adult and geriatric patients increased during the COVID period (p<0001). Conclusion. Despite all the negativity caused by the outbreak, this period has been one in which the public is aware of unnecessary emergency room which has been subsequently lessened.
介绍。新型冠状病毒(2019-nCoV)疫情已成为全球共同面临的问题。的目标。目的:探讨新型冠状病毒流行期对我国急诊入院人数的影响。材料和方法。本研究设计为回顾性队列研究。2020年3月11日,我国确诊首例新型冠状病毒感染的肺炎病例。考虑到2020年3月11日的日期,我们调查了两个为期7天的急诊室入院情况,即covid -19前和covid -19。人口统计数据,入院诊断,重要发现,在急诊室停留时间,终止和急诊科死亡率检查。创建了一组“老年”患者人群,以检查65岁及以上患者的入院特征。结果。该研究包括3466名患者。新冠肺炎前期平均每日入院人数(350.4±54.5)显著高于新冠肺炎期间(144.7±20.2,p=0001)。在COVID期间,心源性入院比例上升,胃肠道入院比例下降(p<0001)。在COVID期间,成人和老年患者的住院率均有所增加(p<0001)。结论。尽管疫情造成了所有负面影响,但这一时期是公众意识到不必要的急诊室的时期,这种急诊室后来减少了。
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引用次数: 1
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临床和实验医学杂志
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