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Long-Term Effects of School-Based CBT in Low-Risk Children and Adolescents: A Bayesian Meta-Analysis 基于学校的CBT对低风险儿童和青少年的长期影响:贝叶斯荟萃分析。
IF 2.5 3区 心理学 Q2 PSYCHOLOGY, CLINICAL Pub Date : 2025-11-24 DOI: 10.1002/jclp.70069
Xiangying Zhang, Zhide Liang, Jihye Kang

Background

Depression and anxiety are increasingly common among children and adolescents. While school-based cognitive behavioral therapy (CBT) is a promising intervention, most research has focused on its effects in high-risk or symptomatic populations. This leaves a critical gap in our understanding of its effectiveness as a universal prevention strategy for the general, low-risk student population. Establishing whether CBT can benefit low-risk students is crucial for developing proactive, school-wide mental health systems aimed at preventing future problems before they emerge. This study aimed to fill this gap by evaluating the short- and long-term effects of universal school-based CBT on low-risk children and young people, providing insights for optimizing intervention programs.

Methods

Systematic searches of MEDLINE, Embase, the Cochrane Library, Web of Science, and PsyInfo were conducted from inception to January 15, 2025 to identify randomized controlled trials (RCTs) of school-based CBT for depression and anxiety in low-risk populations. Paired and regression meta-analyses of these results were conducted using Bayesian hierarchical models.

Results

The 31 RCTs included a total of 19,865 children and young people. Compared to the control group, school-based CBT produced a statistically significant but very small improvement in depressive symptoms (SMD: −0.06, 95% CrI: −0.08 to −0.04) and a small reduction in anxiety symptoms (SMD: −0.19, 95% CrI: −0.22 to −0.17). These effects appeared to be maintained for up to 1 year. Exploratory analyses suggested that males may benefit more from anxiety interventions.

Conclusion

This study provides the first meta-analytic evidence that universal school-based CBT can produce small but durable, long-term preventive effects in low-risk youth. Although the very low quality of the underlying evidence means the findings are not robust enough to support widespread implementation at this time, they establish a crucial signal of effectiveness. The primary implication is that universal CBT is a promising strategy that warrants significant investment in future high-quality, large-scale trials to confirm its real-world value.

背景:抑郁和焦虑在儿童和青少年中越来越普遍。虽然以学校为基础的认知行为疗法(CBT)是一种很有前途的干预手段,但大多数研究都集中在其对高风险或有症状人群的影响上。这使得我们对其作为一般低风险学生群体的普遍预防策略的有效性的理解存在重大差距。确定CBT是否能使低风险学生受益,对于建立积极主动的全校范围的心理健康系统至关重要,该系统旨在预防未来的问题出现。本研究旨在通过评估以学校为基础的通用CBT对低风险儿童和青少年的短期和长期影响来填补这一空白,为优化干预方案提供见解。方法:系统检索MEDLINE、Embase、Cochrane图书馆、Web of Science和PsyInfo,检索时间为2025年1月15日,以确定基于学校的CBT治疗低危人群抑郁和焦虑的随机对照试验(RCTs)。使用贝叶斯层次模型对这些结果进行配对和回归meta分析。结果:31项随机对照试验共纳入19865名儿童和青少年。与对照组相比,以学校为基础的CBT在抑郁症状(SMD: -0.06, 95% CrI: -0.08至-0.04)和焦虑症状(SMD: -0.19, 95% CrI: -0.22至-0.17)方面产生了统计学上显著但非常小的改善。这些效果似乎维持了长达1年。探索性分析表明,男性可能从焦虑干预中获益更多。结论:本研究提供了第一个荟萃分析证据,证明普遍的基于学校的CBT可以在低风险青少年中产生小但持久的长期预防效果。尽管基础证据的质量很低,这意味着这些发现还不足以支持目前的广泛实施,但它们确立了有效性的关键信号。主要的含义是,通用CBT是一种有前途的策略,需要在未来高质量的大规模试验中进行大量投资,以确认其现实世界的价值。
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引用次数: 0
Metacognitive Interpersonal Therapy - Eating Disorders (MIT-ED) in the Case of an 18-Year-Old Girl With Avoidant and Obsessive-Compulsive Personality Disorders, Binge Eating Disorder and Obesity 元认知人际治疗-进食障碍(MIT-ED)在一名患有回避型和强迫性人格障碍、暴食症和肥胖的18岁女孩的案例中。
IF 2.5 3区 心理学 Q2 PSYCHOLOGY, CLINICAL Pub Date : 2025-11-24 DOI: 10.1002/jclp.70064
Gloria Fioravanti, Angus MacBeth, Martina Nicolis, Elisa Gala, Giancarlo Dimaggio

Personality disorders (PD) in adolescents are a significant risk factor in the development and maintenance of eating disorders (ED). Comorbid PD and ED can influence each other and significantly impact on the young person′s well-being, worsening interpersonal relationships and social functioning. Patients with ED often use coping mechanisms related to food and body shape as maladaptive attempts to manage PD-related problems, like negative ideas about self and others. We describe the case of an 18-year-old adolescent presenting with binge eating disorder (BED), stage I obesity, and Avoidant and Obsessive-Compulsive Personality Disorders, treated with Metacognitive Interpersonal Therapy for Eating Disorders (MIT-ED). The patient reported low self-esteem and insecurity about her decision. When her need for autonomy was frustrated, she adopted dysfunctional behaviors such as chasing perfectionistic goals to increase her self-esteem. Further, when criticized feeling useless, she would mitigate her feelings of shame and sadness through social withdrawal and binge eating. Therapy focused on improving awareness of the mental states that contribute to social withdrawal and dysfunctional eating behaviors and to build psychological resources to support self-worth and autonomy. We describe the addition of family therapy to the treatment protocol to address some of the interpersonal and relational dynamics that maintained Asia′s sense of herself as worthless and unable to pursue her own goals. Implications for treating adolescents presenting with comorbid PD and ED are discussed.

青少年人格障碍(PD)是饮食失调(ED)发展和维持的重要危险因素。共病性PD和ED可以相互影响,并显著影响年轻人的幸福感,恶化人际关系和社会功能。ED患者经常使用与食物和体型相关的应对机制作为不适应的尝试来管理与pd相关的问题,如对自己和他人的消极想法。我们描述了一例18岁的青少年暴食症(BED), I期肥胖,回避型和强迫性人格障碍,用进食障碍元认知人际治疗(MIT-ED)治疗。病人报告说,她对自己的决定缺乏自尊和不安全感。当她对自主的需求受挫时,她采取了一些不正常的行为,比如追求完美主义的目标来增强自尊。此外,当被批评感到无用时,她会通过社交退缩和暴饮暴食来缓解自己的羞耻感和悲伤感。治疗的重点是提高对导致社交退缩和不正常饮食行为的心理状态的认识,并建立支持自我价值和自主的心理资源。我们描述了在治疗方案中增加家庭治疗,以解决一些人际关系和关系的动态,这些动态使亚洲觉得自己毫无价值,无法追求自己的目标。讨论了青少年PD和ED合并症的治疗意义。
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引用次数: 0
Mentalization-Based Group Therapy for Personality Disorder in Adolescence: A Single Case Study 以心理为基础的青少年人格障碍团体治疗:单一个案研究。
IF 2.5 3区 心理学 Q2 PSYCHOLOGY, CLINICAL Pub Date : 2025-11-19 DOI: 10.1002/jclp.70067
Kasper Pyndt, Kathrine Hesselberg Nikolajsen

Treating personality disorders in adolescents presents a significant challenge, as intense emotions and unstable relationships often lead to early dropout from therapy. This is particularly concerning, given that psychotherapy is the primary treatment for personality disorders and that such a diagnosis is typically associated with severe difficulties daily functioning. The case report of a 16-year-old girl with borderline personality disorder illustrates how a history of trauma and early unstable relationships can contribute to later difficulties in emotion regulation and impair the ability to think clearly under pressure. During group therapy, interpersonal conflicts were resolved as the girl became increasingly able to understand both her own mind and the mind of others. A new conflict arose and intensified when the therapists were required to inform external authorities, highlighting the importance of mentalizing within the team and the advantages of a team-based approach to treating personality disorders, which includes a combined treatment of both individual and group therapy. The case illustration demonstrates how mentalization-based interventions can help rebuild trust and repair misunderstandings in therapy, thereby preventing dropout and illustrating the potential of psychotherapy for these patients. Concrete examples of possible interventions for managing interpersonal conflict in group therapy are provided with the aim of encouraging others to engage in the treatment of personality disorders in adolescence.

治疗青少年人格障碍是一项重大挑战,因为强烈的情绪和不稳定的关系往往导致早期退出治疗。这尤其令人担忧,因为心理治疗是人格障碍的主要治疗方法,而这种诊断通常与日常功能的严重困难有关。一名患有边缘性人格障碍的16岁女孩的病例报告说明了创伤史和早期不稳定的关系如何导致后来情绪调节的困难,并损害了在压力下清晰思考的能力。在集体治疗中,人际冲突得到了解决,因为女孩越来越能够理解自己的想法和他人的想法。当治疗师被要求告知外部权威时,新的冲突出现并加剧,强调了团队内部心理治疗的重要性以及以团队为基础的治疗人格障碍的方法的优势,包括个人和团体治疗的结合治疗。案例说明了基于心理的干预如何帮助重建信任和修复治疗中的误解,从而防止辍学,并说明了心理治疗对这些患者的潜力。提供了在团体治疗中管理人际冲突的可能干预措施的具体例子,目的是鼓励其他人参与青少年人格障碍的治疗。
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引用次数: 0
Some Deliberations on Deliberate Practice in Psychotherapy: A Commentary 心理治疗中刻意练习的若干思考:述评。
IF 2.5 3区 心理学 Q2 PSYCHOLOGY, CLINICAL Pub Date : 2025-11-14 DOI: 10.1002/jclp.70065
James Macdonald, John Christopher Muran, Giancarlo Dimaggio

In this commentary on the issue of the Journal of Clinical Psychology: In Session dedicated to Deliberate Practice (DP), we highlight commonalities between DP supervision as illustrated in the target papers and Alliance-Focused Training (AFT) and applaud the shift towards more experiential learning. We also note one major difference, namely the absence of Behavioral Rehearsal (BR) in AFT in spite of this being a key element of DP as conceptualised in the Sentio Supervision Model and in the target papers. We then offer some critique of DP as modelled in this issue. We suggest that empirical evidence on what constitutes therapeutic expertise is undeveloped. Consequently, there is a risk of building a super-structure of DP on foundations that still await solid empirical support. We note how DP might be tailored more closely to what is known about therapeutic effectiveness, drawing on process research and Task Analysis. We then suggest that DP may have failed to sufficiently conceptualise the relational nature of therapeutic expertise—different in character to skill training in fields where DP was originally formulated and developed. We argue that processes of interpersonal attunement offer a frame in which parenting skills, developmental psychopathology, the earning of secure attachment both in and outside of therapy, and the safe base of supervision can all be gathered into a unifying paradigm. We end by arguing that the ability to be mindfully present in relationship underpins the experiential depth and skilful responsiveness at the heart of both attachment and successful psychotherapy.

在这期《临床心理学杂志》的评论中:在专门讨论刻意练习(DP)的会议上,我们强调了目标论文中所述的DP监督与联盟重点培训(AFT)之间的共性,并赞扬了向更多体验式学习的转变。我们还注意到一个主要的区别,即在AFT中缺乏行为排练(BR),尽管这是情感监督模型和目标论文中概念化的DP的关键要素。然后,我们对本期建模的DP提出一些批评。我们认为,关于什么是治疗专业知识的经验证据尚未开发。因此,有一种风险是,在仍有待可靠的经验支持的基础上建立一个DP的上层结构。我们注意到,利用过程研究和任务分析,DP如何更接近于已知的治疗效果。然后我们认为,DP可能未能充分概念化治疗专业知识的关系性质-与DP最初制定和发展的领域的技能培训性质不同。我们认为,人际协调的过程提供了一个框架,在这个框架中,育儿技能、发展精神病理学、治疗内外安全依恋的获得以及监督的安全基础都可以聚集到一个统一的范式中。最后,我们认为,在一段关系中专注的能力支撑着体验的深度和熟练的反应,这是依恋和成功的心理治疗的核心。
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引用次数: 0
Dampening of Positive Affect Serves an Emotional Contrast Avoidance Function: Preliminary Evidence From an Adult Community Sample 积极情绪的抑制服务于情绪对比回避功能:来自成人社区样本的初步证据。
IF 2.5 3区 心理学 Q2 PSYCHOLOGY, CLINICAL Pub Date : 2025-11-10 DOI: 10.1002/jclp.70060
Liesbeth Bogaert, Miguel A. Segura-Vargas, Barnaby D. Dunn, David J. Hallford, Michelle G. Newman, Filip Raes

Dampening of positive affect (PA) constitutes a transdiagnostic risk and maintenance factor for affective dysregulation in various psychopathologies, including depression. However, the motives underlying this PA downregulation strategy remain unclear, even though they may be highly relevant for improving traditional psychological treatments. This study examined whether avoidance of negative emotional contrasts (NECs) and diminished preference for positive emotions were predictive of dampening. The latter was operationalised as low pro- and high contra-hedonic emotion regulation (ER) goal endorsement. An adult community sample (N = 159) completed an online survey, and multiple linear regressions were conducted to examine the predictive validity of both factors, after controlling for age, gender, and repetitive negative thinking (RNT). Higher levels of NEC avoidance and higher contra-hedonic ER goal endorsement were consistently found to uniquely predict concurrent dampening levels, above and beyond age, gender and RNT. Crucially, inclusion of both factors in the same regression model still yielded evidence for the unique predictive validity of NEC avoidance. Findings support the possibility that dampening is motivated by NEC avoidance rather than solely by emotional preferences. Study limitations are noted, and implications for future research and clinical practice are discussed.

积极情绪抑制(PA)是多种精神病理(包括抑郁症)中情感失调的跨诊断风险和维持因素。然而,这种PA下调策略背后的动机尚不清楚,尽管它们可能与改善传统心理治疗高度相关。本研究考察了回避消极情绪对比(NECs)和减少对积极情绪的偏好是否预示着抑郁。后者被操作为低亲高反快乐情绪调节(ER)目标背书。一个成人社区样本(N = 159)完成了一项在线调查,在控制了年龄、性别和重复性消极思维(RNT)后,进行了多元线性回归来检验这两个因素的预测有效性。高水平的NEC避免和高水平的反享乐性ER目标支持被一致地发现能够唯一地预测并发抑制水平,高于年龄、性别和RNT。至关重要的是,在同一回归模型中包含这两个因素仍然为NEC回避的独特预测有效性提供了证据。研究结果支持这样一种可能性,即抑制是由NEC回避引起的,而不仅仅是由情感偏好引起的。本文指出了研究的局限性,并讨论了对未来研究和临床实践的影响。
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引用次数: 0
A Randomized Controlled Trial Comparing Group Transdiagnostic Behavior Therapy (TBT) and Group Disorder-Specific Psychotherapies in Veterans With Emotional Disorders 比较退伍军人情绪障碍群体跨诊断行为治疗(TBT)和群体障碍特异性心理治疗的随机对照试验。
IF 2.5 3区 心理学 Q2 PSYCHOLOGY, CLINICAL Pub Date : 2025-11-07 DOI: 10.1002/jclp.70063
Daniel F. Gros, Nicholas P. Allan, Jeffrey M. Pavlacic

Objective

Transdiagnostic psychotherapies offer potential advantages to traditional, disorder-specific approaches, including coverage of comorbidity, dissemination and implementation, and patient access. Although initial investigations testing the efficacy and capability to be disseminated exist, very few studies have tested these interventions within group settings.

Methods

The present study involved a randomized clinical trial of Group Transdiagnostic Behavior Therapy (G-TBT) and matching group disorder-specific therapies (G-DST) in 243 veterans with major depressive disorder (MDD) and posttraumatic stress disorder (PTSD). Clinical symptom outcomes, patient satisfaction and participation, and access in terms of days between intake and the initiation of treatment were examined. G-DSTs were Cognitive Behavioral Therapy for Depression and Cognitive Processing Therapy for PTSD. Groups were initiated as soon as at least 6 participants were assigned.

Results

As expected, clinical outcomes for MDD and PTSD symptoms were consistently reduced in G-TBT within principal diagnostic groups, as well as associated symptoms and functional impairment. These outcomes were generally consistent with outcomes in the G-DSTs. While therapy satisfaction was similar across groups, significantly faster group assignment and less attrition were observed in G-TBT compared to G-DSTs.

Conclusions

Together, the present findings provide support for the efficacy of G-TBT and with comparable effects to well-established G-DSTs for MDD and PTSD, but with potentially improved access to care via transdiagnostic assignment compared to tradition disorder-specific assignment for group therapies.

目的:与传统的、针对特定疾病的治疗方法相比,跨诊断心理治疗提供了潜在的优势,包括合并症的覆盖、传播和实施以及患者的可及性。虽然存在测试有效性和传播能力的初步调查,但很少有研究在群体环境中测试这些干预措施。方法:对243例重度抑郁障碍(MDD)和创伤后应激障碍(PTSD)退伍军人进行群体跨诊断行为治疗(G-TBT)和匹配群体障碍特异性治疗(G-DST)的随机临床试验。临床症状结果,患者满意度和参与,以及从摄入到开始治疗之间的天数。G-DSTs分别是抑郁症的认知行为治疗和PTSD的认知加工治疗。一旦分配到至少6名参与者,就开始分组。结果:正如预期的那样,在主要诊断组中,G-TBT患者的MDD和PTSD症状的临床结果以及相关症状和功能损伤都持续降低。这些结果与G-DSTs的结果基本一致。虽然各组的治疗满意度相似,但与G-DSTs相比,G-TBT的组分配明显更快,磨损更少。结论:总之,目前的研究结果为G-TBT的疗效提供了支持,并与已建立的G-DSTs在治疗重度抑郁症和创伤后应激障碍方面的效果相当,但与传统的群体治疗疾病特异性分配相比,通过转诊断分配有可能改善获得护理的机会。
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引用次数: 0
What Emerging Treatments Teach us About Psychotherapy for Adolescent Personality Disorder and the Road Ahead 新出现的治疗方法教给我们的关于青少年人格障碍的心理治疗和未来的道路。
IF 2.5 3区 心理学 Q2 PSYCHOLOGY, CLINICAL Pub Date : 2025-11-04 DOI: 10.1002/jclp.70061
Mie Sedoc Jørgensen

This commentary, written for Journal of Clinical Psychology: In Session, synthesizes five case-based contributions on psychotherapy for adolescents with personality disorders (PDs). Although PDs often emerge in adolescence, age-adapted treatments remain scarce. Randomized clinical trials are still limited, making carefully constructed case studies important for identifying promising treatments. Three of the featured cases draw on mentalization-based therapy for adolescents, implemented in combined group–individual formats, adapted toward dimensional models of PD, or extended socioecologically to involve wider social networks, such as family, peers, and school systems. The remaining two derive from metacognitive approaches: one applying Metacognitive Interpersonal Group Therapy (MIT) for Adolescents in a case of dependent and borderline PD, and the other applying MIT for Eating Disorders with an adolescent with binge eating disorder and comorbid avoidant and obsessive–compulsive PD. Across studies, four shared priorities emerge. First, the capacity to think, reason, and regulate mental states, defined as mentalizing or metacognition, serves as a central mechanism of change. Second, impairments in self and interpersonal functioning are treated as the core pathology in PDs. Third, therapeutic progress depends on actively engaging the adolescent's broader social context rather than working solely within the therapist–patient dyad. Fourth, comorbidity, whether trauma-related disorders, substance use, eating disorders, or others, should be treated integratively to ensure targeted, personalized treatment. These cases demonstrate that innovation in adolescent PD treatment often begins with single cases. The task ahead is to translate these clinical examples into rigorously tested, developmentally sensitive, and ecologically grounded intervention models that can be applied in early intervention programs.

这篇发表在《临床心理学杂志:会期》上的评论综合了5个针对青少年人格障碍(pd)的心理治疗案例。虽然pd通常出现在青春期,但适合年龄的治疗方法仍然很少。随机临床试验仍然有限,因此精心构建的病例研究对于确定有希望的治疗方法很重要。其中三个典型案例采用了基于心理的青少年治疗,采用群体-个人结合的形式实施,适应PD的维度模型,或从社会生态学角度扩展到更广泛的社会网络,如家庭、同伴和学校系统。其余两项来自元认知方法:一项应用元认知人际团体治疗(MIT)治疗依赖型和边缘型PD的青少年,另一项应用MIT治疗暴食症和伴发回避型和强迫性PD的青少年的饮食失调。在研究中,出现了四个共同的优先事项。首先,思考、推理和调节心理状态的能力,被定义为心理化或元认知,是变化的核心机制。第二,自我和人际功能障碍被视为pd的核心病理。第三,治疗的进展取决于积极参与青少年更广泛的社会背景,而不是仅仅在治疗师-患者的二元关系中工作。第四,合并症,无论是创伤相关疾病、物质使用、饮食失调还是其他疾病,都应该综合治疗,以确保有针对性的个性化治疗。这些病例表明,青少年帕金森病治疗的创新往往始于单个病例。未来的任务是将这些临床实例转化为经过严格测试的、对发育敏感的、基于生态的干预模型,这些模型可以应用于早期干预计划。
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引用次数: 0
Understanding the Co-occurrence of Depressive and Anxiety Symptoms Among 2021 Henan Flood Victims Through Panel Network Analysis: A 6-Month, Three-Wave Longitudinal Study 通过面板网络分析了解2021名河南洪水灾民抑郁和焦虑症状的共发:一项为期6个月的三波纵向研究
IF 2.5 3区 心理学 Q2 PSYCHOLOGY, CLINICAL Pub Date : 2025-11-04 DOI: 10.1002/jclp.70062
Zhenfeng Zhou, Zhihao Ma

Previous studies have mostly used cross-sectional network to analyze the co-occurrence of depression and anxiety, but this method cannot capture the temporal influences between symptoms. This study uses longitudinal data to explore the dynamic structure of the cooccurrence of depressive and anxiety symptoms among flood victims in Henan in 2021. Data were collected at 3-month intervals from July 20, 2021, to January 30, 2022, and the final sample included 279 disaster victims reporting on items measuring anxiety and depression. We employ the generalized vector autoregressive model approach to estimate network models. The contemporaneous network results show that, within the same measurement occasion, all connections between anxiety and depressive symptoms are positive, with the strongest connection observed between “Sleep” and “Appetite”. And “Nervous” is the most central symptom, while “Irritable” and “Motor” are the top two strongest bridge symptoms. The temporal network results indicate that depressive symptoms are more temporally causal and predictive, while the temporal associations between anxiety symptoms are rare. And depressive symptoms were found to predict anxiety symptoms. Additionally, “Suicide” and “Concentration” showed significant positive autocorrelations, indicating a self-sustaining capacity. “Anhedonia” has the highest in-strength centrality (incoming influence from prior time point), demonstrating the most downstream effect. In contrast, “Concentration” has an out-strength centrality (outgoing influence to the next time point) far exceeding that of other symptoms, suggesting it has the most outward influence. These patterns suggest testable, symptom-focused priorities for post-disaster care: early attention-focused strategies to curb downstream spread from concentration problems; behavioral activation for anhedonia; proactive safety planning and scheduled follow-ups for suicidal ideation; brief transdiagnostic modules targeting irritability and motor activation to reduce comorbidity; and integrated routines addressing the sleep–appetite dyad. Implications are observational and intended to inform hypothesis-driven trials and service planning.

以往的研究多采用横断面网络来分析抑郁和焦虑的共现,但这种方法无法捕捉症状间的时间影响。本研究采用纵向数据,探讨2021年河南省洪水灾民抑郁和焦虑症状共存的动态结构。从2021年7月20日到2022年1月30日,每隔3个月收集一次数据,最终样本包括279名灾难受害者,他们报告了测量焦虑和抑郁的项目。我们采用广义向量自回归模型方法来估计网络模型。同时网络结果显示,在同一测量场合下,焦虑和抑郁症状之间的所有联系都是正的,其中“睡眠”和“食欲”之间的联系最强。“紧张”是最核心的症状,而“易怒”和“运动”是前两个最强的桥状症状。时间网络结果表明,抑郁症状更具时间因果性和预测性,而焦虑症状之间的时间关联则很少。并且发现抑郁症状可以预测焦虑症状。此外,“自杀”和“专注”表现出显著的正相关,表明自我维持能力。“快感缺乏”具有最高的强度中心性(来自前一个时间点的传入影响),显示出最大的下游效应。相反,“注意力集中”的外向中心性(对下一个时间点的外向影响)远远超过其他症状,表明它的外向影响最大。这些模式表明灾后护理的可检验的、以症状为重点的优先事项:早期以注意力为重点的战略,以遏制注意力集中问题向下游扩散;快感缺乏的行为激活;主动的安全计划和对自杀意念的定期随访;针对易怒和运动激活的简短诊断模块,以减少合并症;以及解决睡眠和食欲问题的综合日常活动。影响是观察性的,旨在为假设驱动的试验和服务规划提供信息。
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引用次数: 0
The Potential Role of Serum Iron in Depression: Further Exploration of Future Research Directions 血清铁在抑郁症中的潜在作用:未来研究方向的进一步探索。
IF 2.5 3区 心理学 Q2 PSYCHOLOGY, CLINICAL Pub Date : 2025-11-03 DOI: 10.1002/jclp.70058
Xie Wang, Hong Chen, Ze Chang, Juan Zhang, Shijian Cao
<div> <section> <h3> Background</h3> <p>Depressive disorder (DD) is a common affective disorder with an unclear specific etiology. Although many previous studies have suggested that iron metabolism is involved in the development of DD, there is a lack of validated genetic evidence regarding whether iron metabolism-related indices (i.e., total iron binding capacity, transferrin saturation, ferritin, and serum iron) are causally related to DD.</p> </section> <section> <h3> Methods</h3> <p>This study conducted a bidirectional Mendelian randomization (MR) analysis based on the largest existing genome-wide association study (GWAS) dataset. We used MR to investigate the causal relationship between iron metabolism indicators and DD by controlling for confounding factors and utilizing randomly assigned genetic instrumental variables that are not affected by any causal effects.</p> </section> <section> <h3> Results</h3> <p>Through coordinated analysis of 86 iron metabolism-related SNPs and 16,380,457 DD-related SNPs, 65 SNPs with genome-wide significance that were found to be related to DD iron homeostasis were screened. The IVW analysis results suggest that total iron binding capacity (TIBC) (β = 0.021; 95% Cl = −0.059 to 0.101; <i>p</i> value = 0.610), transferrin saturation (TSAT) (β = −0.038; 95% Cl = −0.146 to 0.070; <i>p</i> value = 0.489), and ferritin (FER) (β = 0.002; 95% Cl = −0.139 to 0.143; <i>p</i> value = 0.982) have no genetic causal relationship with DD, and serum iron (SI) (β = −0.100; 95% Cl = −0.194 to −0.006; <i>p</i> value = 0.040) is considered to have a genetic causal relationship with DD. The Cochran test of MR-IVW suggests that TSAT (<i>p</i> value = 0.125), FER (<i>p</i> value = 0.089), SI (<i>p</i> value = 0.667), and DD have no heterogeneity in the MR analysis results. The MR Egger level multieffect test results show that TIBC (<i>p</i> value = 0.875), TSAT (<i>p</i> value = 0.585), FER (<i>p</i> value = 0.990), and SI (<i>p</i> value = 0.352) all have no level multieffect. In addition, the IVW analysis results of the effect of DD on iron metabolism indicators suggest that there is no causal relationship between DD and TIBC (β = −0.009; 95% Cl = −0.024 to 0.007; <i>p</i> value = 0.218), TSAT (β = −0.008; 95% Cl = −0.024 to 0.008; <i>p</i> value = 0.277), FER (β = −0.002; 95% Cl = −0.016 to 0.012; <i>p</i> value = 0.761), and SI (β = −0.008; 95% Cl = −0.024 to 0.008; <i>p</i> value = 0.263). The results of the sensitivity analysis indicate that no heterogeneity or horizontal pleiotropy was present in the observed results (<i>p</i> > 0.05).</p> </section> <section> <h3> Conclusion</h3> <p>The iron metabolism ma
背景:抑郁症(DD)是一种常见的情感性障碍,具体病因尚不清楚。尽管许多先前的研究表明铁代谢参与了DD的发展,但关于铁代谢相关指标(即总铁结合能力、转铁蛋白饱和度、铁蛋白和血清铁)是否与DD有因果关系,缺乏有效的遗传证据。方法:本研究基于现有最大的全基因组关联研究(GWAS)数据集进行了双向孟德尔随机化(MR)分析。通过控制混杂因素和使用不受任何因果效应影响的随机分配的遗传工具变量,我们使用MR来研究铁代谢指标与DD之间的因果关系。结果:通过对86个铁代谢相关snp和16380457个DD相关snp的协同分析,筛选出65个与DD铁稳态相关的具有全基因组意义的snp。IVW分析结果显示,总铁结合容量(TIBC) (β = 0.021, 95% Cl = -0.059 ~ 0.101, p值= 0.610)、转铁蛋白饱和度(TSAT) (β = -0.038, 95% Cl = -0.146 ~ 0.070, p值= 0.489)和铁蛋白(FER) (β = 0.002, 95% Cl = -0.139 ~ 0.143, p值= 0.982)与DD无遗传因果关系,血清铁(SI) (β = -0.100, 95% Cl = -0.194 ~ -0.006;p值= 0.040)被认为与DD存在遗传因果关系,MR- ivw的Cochran检验提示TSAT (p值= 0.125)、FER (p值= 0.089)、SI (p值= 0.667)和DD在MR分析结果中不存在异质性。MR Egger水平多效应检验结果显示,TIBC (p值= 0.875)、TSAT (p值= 0.585)、FER (p值= 0.990)、SI (p值= 0.352)均不存在水平多效应。此外,IVW分析结果DD铁代谢指标的影响表明,之间没有因果关系DD和TIBC(β= -0.009;95% Cl = -0.024到0.007;p值= 0.218),TSAT(β= -0.008;95% Cl = -0.024到0.008;p值= 0.277),带(β= -0.002;95% Cl = -0.016到0.012;p值= 0.761),和SI(β= -0.008;95% Cl = -0.024到0.008;p值= 0.263)。敏感性分析结果显示,观察结果不存在异质性或水平多效性(p < 0.05)。结论:铁代谢指标TIBC、TSAT、FER与DD无遗传因果关系,SI与DD有遗传因果关系,SI水平降低可能增加DD的发病风险,且DD与铁代谢四项指标无明显遗传关联。
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引用次数: 0
Application of Psychometric Methods in Dimensional Analysis and Integration of Assessment Tools in Early Diagnosis for Autism Spectrum Disorder 心理测量方法在自闭症谱系障碍早期诊断维度分析及评估工具整合中的应用。
IF 2.5 3区 心理学 Q2 PSYCHOLOGY, CLINICAL Pub Date : 2025-10-26 DOI: 10.1002/jclp.70059
Ilenia Le Donne, Monica Mazza, Margherita Attanasio, Nicole Covone, Maria Paola Greco, Veronica Scurti, Marco Valenti

Background

Early diagnosis of autism spectrum disorder (ASD) is crucial for timely intervention, and requires reliable and valid screening and diagnostic tools. The Toddler Module of the Autism Diagnostic Observation Schedule, Second Edition (ADOS-2), is widely used but its factor structure and applicability in the clinical practice need further investigation.

Objective

This study aimed to explore the underlying dimensional structure of the ADOS-2 Toddler Module in Italian context, and to examine the association between the identified ASD symptom dimensions and cognitive development, as measured by the Griffiths Mental Development Scales (GMDS).

Methods

The study was conducted in two phases: in Phase 1, Exploratory Graph Analysis (EGA) was used to identify latent dimensions of the ADOS-2 Toddler Module items in a sample of 91 Italian children aged 12–30 months at risk for ASD. In Phase 2, structural equation modeling (SEM) was performed on a subsample of 60 children who completed the GMDS to examine associations between ASD symptom dimensions and cognitive development.

Results

EGA revealed a stable three-factor structure underlying the Toddler Module items. The SEM analysis demonstrated a good model fit and significant associations between ASD symptom dimensions and the Personal-Social subscale of the GMDS.

Conclusions

These findings provide preliminary evidence for a three-dimensional structure of ASD symptoms in very young children and suggest that cognitive development, particularly social-personal skills, is related to early ASD symptomatology. The results have potential implications for refining early diagnostic assessments and guiding clinical practice.

背景:自闭症谱系障碍(ASD)的早期诊断对于及时干预至关重要,需要可靠有效的筛查和诊断工具。《自闭症诊断观察表(第二版)》幼儿模块应用广泛,但其因素结构及其在临床实践中的适用性有待进一步研究。目的:本研究旨在探讨意大利背景下ADOS-2幼儿模块的潜在维度结构,并通过格里菲斯心理发展量表(GMDS)检测识别出的ASD症状维度与认知发展之间的关系。方法:本研究分为两个阶段进行:第一阶段,采用探索性图表分析(EGA)确定91名12-30月龄有ASD风险的意大利儿童的ADOS-2幼儿模块项目的潜在维度。在第二阶段,对60名完成GMDS的儿童进行结构方程建模(SEM),以检查ASD症状维度与认知发展之间的关系。结果:幼儿模块项目具有稳定的三因素结构。扫描电镜分析表明,ASD症状维度与GMDS的个人-社会子量表之间存在良好的模型拟合和显著的关联。结论:这些发现为非常年幼的儿童ASD症状的三维结构提供了初步证据,并表明认知发展,特别是社交-个人技能,与早期ASD症状有关。研究结果对完善早期诊断评估和指导临床实践具有潜在的意义。
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引用次数: 0
期刊
Journal of Clinical Psychology
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