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The effect of topical 0.5% humic acid gel on male rats with skin ulcer 外用 0.5% 腐植酸凝胶对雄性皮肤溃疡大鼠的影响
Q3 Medicine Pub Date : 2023-11-30 DOI: 10.4103/jcas.jcas_104_23
Fatemeh Samiee-Rad, Fatemeh Ghasemi, Ensiyeh Bahadoran, M. Sofiabadi, Zahra Shalbaf, Armane Taherkhani, N. Gheibi
Humic derivatives have antibacterial and anti-inflammatory properties. This study aimed to assess the experimental wound-healing effect of 0.5% humic acid gel. A full-thickness skin wound was created on the dorsal side of 24 Sprague Dawley male rats (220–250g). The animals were then randomly divided into the control, sham, and experimental groups. Skin wounds were bandaged daily using sterile gauze dipped in normal saline, carboxymethylcellulose, and 0.5% humic acid for 21 days. The wound-healing rate was evaluated grossly and histologically at various time intervals post-injury. Wound-healing percentage was significantly higher in the gel treatment group at all time points (P < 0.05). The mean number of inflammatory cells was significantly lower in the humic acid gel group than in the other groups (P < 0.001). Moreover, the number of new vascular cells and fibroblasts were significantly increased in the humic acid gel compared to the control (P < 0.001). These data confirmed that 0.5% humic acid gel accelerates wound healing, probably by anti-inflammatory effects, as well as by promoting vascular and fibroblast proliferation. Therefore, the humic acid gel may be used to improve wound care.
腐植酸衍生物具有抗菌消炎的特性。 本研究旨在评估 0.5% 腐植酸凝胶的伤口愈合效果。 在 24 只 Sprague Dawley 雄性大鼠(220-250 克)的背侧创建一个全厚皮肤伤口。然后将动物随机分为对照组、假组和实验组。每天用蘸有生理盐水、羧甲基纤维素和 0.5% 腐植酸的无菌纱布包扎皮肤伤口,持续 21 天。在受伤后的不同时间间隔,对伤口愈合率进行大体和组织学评估。 在所有时间点上,凝胶处理组的伤口愈合率都明显更高(P < 0.05)。腐植酸凝胶组的炎症细胞平均数量明显低于其他组(P < 0.001)。此外,与对照组相比,腐植酸凝胶组新生血管细胞和成纤维细胞的数量明显增加(P < 0.001)。 这些数据证实,0.5% 腐植酸凝胶可加速伤口愈合,这可能是通过抗炎作用以及促进血管和成纤维细胞增殖实现的。因此,腐植酸凝胶可用于改善伤口护理。
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引用次数: 0
Custom-made dental prosthetic clip for postoperative management of earlobe keloids 定制义齿夹用于耳垂瘢痕疙瘩术后治疗
Q3 Medicine Pub Date : 2023-11-30 DOI: 10.4103/jcas.jcas_16_23
Vikas Pathania, Rahul Udayasankar
Earlobe keloids are a common condition with varied and cross-specialty presentation. The condition is often recalcitrant and difficult to treat on account of its location. Frequent recurrences following excision is often frustrating for the patient and the surgeon. Application of pressure along with intra-operative and postoperative intralesional steroids is a popular choice and is in vogue by surgeons and dermatologists. However, considering the uniqueness of the structure for every individual, it is often difficult to ensure one size fits all when using pressure therapy as an adjunct. We designed a simple PMMA dental prosthesis to ensure comfortable yet effective constant pressure over the lesion to ensure complete aesthetic outcome without recurrence in an operated earlobe keloid.
耳垂瘢痕疙瘩是一种常见的疾病,其表现多种多样,而且涉及多个专科。由于位置的原因,这种疾病往往顽固难治。切除后经常复发往往令患者和外科医生感到沮丧。在术中、术后使用类固醇激素的同时加压治疗是外科医生和皮肤科医生的普遍选择。然而,考虑到每个人的结构都不尽相同,在使用压力疗法作为辅助手段时,往往很难确保一刀切。我们设计了一种简单的 PMMA 牙科假体,以确保对病变部位施加舒适而有效的恒定压力,从而确保手术后耳垂瘢痕疙瘩不复发,达到完全美观的效果。
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引用次数: 0
Pedunculated superficial angiomyxoma of the thigh mimicking molluscum pendulum 模仿软疣的大腿有蒂浅表血管瘤
Q3 Medicine Pub Date : 2023-11-30 DOI: 10.4103/jcas.jcas_72_23
Abdulmooti Hawilo, Wejdene Fakhfakh, N. Litaiem
Superficial angiomyxoma (SAM) is a rare acquired benign neoplasm. It may be sporadic or associated with Carney’s complex. Typical locations for SAM are the head, neck, and trunk. It usually presents as a skin-colored papule or sessile lobulated nodule. Large pedunculated forms are less common. We describe a sporadic massive pedunculated SAM of the thigh occurring in a 75-year-old man and provide a comprehensive summary of SAM characteristics.
表皮血管瘤(SAM)是一种罕见的获得性良性肿瘤。它可能是散发性的,也可能与卡尼氏综合征有关。SAM的典型发病部位是头部、颈部和躯干。它通常表现为皮肤色丘疹或无梗分叶结节。大的有蒂结节较少见。我们描述了一名 75 岁男性大腿上的散发性大块有蒂 SAM,并全面总结了 SAM 的特征。
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引用次数: 0
Giant neglected unresectable ulcerated basal cell carcinoma of face: Radiotherapy at rescue 面部巨大的被忽视的无法切除的溃疡性基底细胞癌:放射治疗抢救
Q3 Medicine Pub Date : 2023-11-30 DOI: 10.4103/jcas.jcas_62_23
Shubham Kumar, S. Patra, Bharti Devnani, Varun Rajagopalan, Maninder Kaur
Basal cell carcinomas are typically considered indolent and slowly progressing tumors, but giant basal cell carcinomas are more aggressive with more risk of invasion and poor prognosis. management of such giant BCCs is difficult due to difficulty in surgical approach. we hereby reporting a case of giant ulcerated BCC of face treated with radiotherapy as a rescue treatment.
基底细胞癌通常被认为是进展缓慢的轻度肿瘤,但巨型基底细胞癌更具侵袭性,侵袭风险更高,预后较差。
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引用次数: 0
The effect of combining humic and fulvic acids poultice on wound healing in male rats 腐植酸和富勒酸混合膏药对雄性大鼠伤口愈合的影响
Q3 Medicine Pub Date : 2023-11-30 DOI: 10.4103/jcas.jcas_92_23
N. Gheibi, Fatemeh Samiee-Rad, M. Sofiabadi, Ebrahim Mosayebi, Zahra Shalbaf
Finding new compounds to accelerate wound healing is critical today. Humic substances or fulvic acid each have anti-inflammatory properties. The purpose of this study is to determine the effects of poultice 0.5% containing humic and fulvic acids on wound healing in male rats. An animal model was arranged by making a full-thickness skin wound was created in each rat. Animals were randomly divided into control, sham, and treatment groups. To investigate the effect of humic and fulvic acids combining poultice, the wound area and histological analyses of the number of inflammatory cells, fibroblasts, and angiogenesis were evaluated for 21 days. The animals in the treated group showed higher wound healing percentage, angiogenesis, and fibroblast distribution compared with the control (P < 0.001). Moreover, the topical administration of humic and fulvic acids 0.5% poultice decreased the mean number of inflammatory cells significantly than the other groups (P < 0.001). The topical administration of a poultice containing humic and fulvic acid accelerated wound healing by increasing angiogenesis and fibroblast and reducing inflammatory cell distribution in a rat model.
如今,寻找加速伤口愈合的新化合物至关重要。腐殖质或富勒酸都具有抗炎特性。 本研究旨在确定含腐植酸和富勒酸的 0.5% 膏药对雄性大鼠伤口愈合的影响。 研究安排了一个动物模型,为每只大鼠制作了一个全厚皮肤伤口。动物被随机分为对照组、假治疗组和治疗组。为了研究腐植酸和富勒酸复合膏药的效果,对伤口面积和炎症细胞、成纤维细胞数量及血管生成的组织学分析进行了为期 21 天的评估。 与对照组相比,治疗组动物的伤口愈合率、血管生成和成纤维细胞分布均高于对照组(P < 0.001)。此外,腐植酸和富勒酸 0.5%膏药外敷组比其他组明显减少了炎症细胞的平均数量(P < 0.001)。 在大鼠模型中,通过增加血管生成和成纤维细胞以及减少炎症细胞分布,局部使用含腐植酸和富勒酸的膏药可加速伤口愈合。
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引用次数: 0
Malignant proliferating trichilemmal tumor in male: A rare case entity with diagnostic dilemma 男性恶性增生性三叶虫瘤:诊断困难的罕见病例实体
Q3 Medicine Pub Date : 2023-11-30 DOI: 10.4103/jcas.jcas_90_23
Gulab D Yadav, Prem Shanker, Shubham Singh, Avishek Koley
Trichilemmal tumor is a rare hair follicle tumor that is, thought to occur from a malignant transformation of a benign trichilemmoma. The tumor develops from the outer root sheath of the hair follicle. The patient underwent a wide local excision with 1 cm clear margin. The defect was covered by split thick skin graft harvested from ipsilateral thigh after consulting the plastic surgery department. Trichilemmal cyst can be misdiagnosed as other cutaneous lesions. Like in our case, initial FNAC was suggestive of a epidermoid cyst but post excision Histopathological examination gave us the real picture of a trichilemmal tumor. Recurrent tumors are very rare and can get misdiagnosed as squamous cell carcinoma. Malignant proliferating trichilemmal tumors are rare cutaneous tumors that are very rare in males. These tumors can be misdiagnosed as squamous cell carcinoma and require external stimuli for malignant conversion from benign counterparts. Wide local excision is sufficient for treatment.
三毛瘤是一种罕见的毛囊肿瘤,被认为是由良性三毛瘤恶性转化而来。肿瘤从毛囊外根鞘处生长。患者接受了局部大范围切除术,边缘清晰 1 厘米。在咨询整形外科后,从同侧大腿上采集的厚皮瓣移植覆盖了缺损处。三叶虫囊肿可能被误诊为其他皮肤病变。就像我们的病例一样,最初的FNAC检查提示为表皮样囊肿,但切除后的组织病理学检查却让我们看到了三鳃膜肿瘤的真实面目。复发性肿瘤非常罕见,可能会被误诊为鳞状细胞癌。恶性增生性三基底膜瘤是一种罕见的皮肤肿瘤,在男性中非常罕见。这些肿瘤可能被误诊为鳞状细胞癌,需要外部刺激才能从良性肿瘤转化为恶性肿瘤。治疗时只需局部广泛切除即可。
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引用次数: 0
Efficacy of autologous platelet rich plasma with subcision vs platelet rich plasma with microneedling in atrophic acne scars: A single-center, prospective, intra-individual split-face comparative study 萎缩性痤疮疤痕的自体富血小板血浆亚切术与富血小板血浆微针疗法的疗效对比:单中心、前瞻性、个体内分面比较研究
Q3 Medicine Pub Date : 2023-11-30 DOI: 10.4103/jcas.jcas_218_22
M. Yadav, P. Soni, B. Ghiya, R. Mehta, A. Arora, V. Jangir, Rajesh Khokhar, S. Pareek
Severe post-acne scarring has been implicated as a cause of considerable psychological distress, mainly among adolescents. Subcision and microneedling are cutting-edge treatment options available nowadays. In this study, we aimed to compare the efficacy of microneedling with platelet-rich plasma (PRP) against subcision with PRP in treating atrophic post-acne scars in a split-face study design. Fifty patients with atrophic post-acne facial scars were included in this prospective interventional study. Group A included the left side of the face managed by microneedling with PRP and group B included the right side of the face that was subjected to subcision with PRP. Results were assessed based on Goodman and Baron qualitative and quantitative grading. In our study, at the end of the treatment, on the left side, 5 (10%) had 1 grade of improvement showing good response, 35 (70%) had 2 grades of improvement showing very good response, and 10 (20%) had 3 grades of improvement showing excellent response. On the right side, 1 (2%) patient had no improvement in acne grade showing poor response, 9 (18%) had 1 grade of improvement showing good response, 25 (50%) had 2 grades of improvement showing very good response, whereas 15 (30%) had 3 grades of improvement showing excellent response. Till date, apart from ours no other study has compared the two modalities head-to-head with adjuvant PRP in both groups. Although both modalities showed statistically significant results individually, there was no significant difference in qualitative improvement of acne scars between the two groups.
严重的痤疮后瘢痕已被认为是造成相当大的心理压力的原因,主要是在青少年中。皮下注射和微针疗法是当今最先进的治疗方法。 在本研究中,我们采用分面研究设计,旨在比较富血小板血浆(PRP)微针疗法与富血小板血浆亚切削疗法治疗萎缩性痤疮后疤痕的疗效。 这项前瞻性干预研究共纳入了 50 名萎缩性痤疮后面部疤痕患者。A 组包括采用 PRP 微针疗法的左侧面部,B 组包括采用 PRP 亚切口疗法的右侧面部。结果根据古德曼和巴伦的定性和定量分级进行评估。 在我们的研究中,治疗结束时,左侧脸部有 5 人(10%)改善了 1 个等级,显示反应良好;35 人(70%)改善了 2 个等级,显示反应非常好;10 人(20%)改善了 3 个等级,显示反应极佳。在右侧,1 名患者(2%)的痤疮等级没有改善,显示反应较差;9 名患者(18%)的痤疮等级改善了 1 级,显示反应良好;25 名患者(50%)的痤疮等级改善了 2 级,显示反应非常好;而 15 名患者(30%)的痤疮等级改善了 3 级,显示反应极佳。 迄今为止,除了我们的研究外,还没有其他研究对这两种模式进行过正面比较,并在两组中都使用了 PRP 辅助治疗。虽然这两种方法在统计学上都显示出显著的效果,但两组在痤疮疤痕的质量改善方面没有明显差异。
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引用次数: 0
Anaphylactic reaction to hyaluronidase use for a complication of lip augmentation with hyaluronic acid 透明质酸丰唇并发症中使用透明质酸酶引起的过敏反应
Q3 Medicine Pub Date : 2023-11-30 DOI: 10.4103/jcas.jcas_99_23
Gisela Seyboth Wild, L. Palma, Susana Morimoto, Priscilla Aparecida Pereira
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引用次数: 0
Single-prick local anesthesia for sebaceous cyst excision 皮脂腺囊肿切除术的单刺局部麻醉
Q3 Medicine Pub Date : 2023-11-30 DOI: 10.4103/jcas.jcas_223_22
Tabassum Mulla, Tushar Jadhav, Nalini Thakur, Ananta Kulkarni
Sebaceous cyst excision is a commonly performed outpatient surgery. Patients are often concerned about intraoperative pain associated with multiple pricks while injecting local anesthesia. Injection of an anesthetic agent with a single prick is reassuring to the patient and encourages the patient to cooperate with the surgeon during rest of the procedure.
皮脂腺囊肿切除术是一种常见的门诊手术。患者通常担心在注射局部麻醉剂时,术中会出现多次刺痛。单刺注射麻醉剂可让患者放心,并鼓励患者在手术的其他部分与外科医生合作。
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引用次数: 0
Efficacy and safety of diode laser for facial hair reduction in hirsutism—a clinico-trichoscopic evaluation 多毛症患者使用二极管激光减少面部毛发的有效性和安全性--临床-腹腔镜评估
Q3 Medicine Pub Date : 2023-11-30 DOI: 10.4103/jcas.jcas_63_23
S. Rafi, Anil Budania, Abhishek Bhardwaj, Saurabh Singh, A. Bains, Benetta Benny, Afroz Alam, Kannan Karthick, Akriti Agarwal, Y. Pathania
Hirsutism is the presence of excessive terminal hair on androgen-dependent sites of the body. Lasers like Alexandrite, diode, and Nd:Yag lasers have been used for hair reduction with varying efficacy. Trichoscopy of hair is a simple noninvasive method of hair assessment. However, it has not been used in the assessment of diode laser hair reduction. This study aimed to assess the efficacy and safety of diode laser hair reduction in skin color with the help of clinical and trichoscopic assessment. This prospective observational study included 73 patients of hirsutism recruited in 18-month period. All participants received sessions of 805nm diode laser at monthly intervals up to six sessions. Clinical and trichoscopic evaluation along with photographs were obtained at each visit. Side effects, if any, were noted in every sitting. All patients were females of Fitzpatrick skin types III–V. All clinical parameters showed statistically significant hair reduction when compared with baseline. Trichoscopic parameters of hair reduction like total hair count, terminal hair count, and terminal/vellus hair ratio showed reduction compared to baseline which was statistically significant (P < 0.05). The most common side effect noted in our study was pain followed by erythema and perifollicular edema. Diode laser is an effective and safe procedure for the reduction of unwanted facial hair, even in darker skin types. We also wish to emphasize that trichoscopy for the assessment of laser hair reduction is a recent, noninvasive, simple, and underutilized tool. No serious adverse events were noted in our study.
多毛症是指人体依赖雄激素的部位出现过多的末端毛发。亚历山大激光器、二极管激光器和掺钕钇钕石榴石激光器等激光器已被用于减少毛发,但效果不一。毛发三频扫描是一种简单的非侵入性毛发评估方法。然而,这种方法尚未用于二极管激光脱毛的评估。 本研究旨在通过临床和三腔镜评估,评估二极管激光脱毛对肤色的有效性和安全性。 这项前瞻性观察研究在 18 个月内招募了 73 名多毛症患者。所有参与者每月接受一次 805nm 二极管激光治疗,最多六次。每次就诊时都要进行临床和三镜检查,并拍摄照片。每次就诊都会记录副作用(如有)。 所有患者均为女性,皮肤类型为 Fitzpatrick III-V。与基线相比,所有临床参数均显示毛发明显减少。毛发减少的三镜参数,如总毛发数、末端毛发数和末端/绒毛比率,与基线相比均有减少,且有统计学意义(P < 0.05)。在我们的研究中,最常见的副作用是疼痛,其次是红斑和毛囊周围水肿。 二极管激光是减少面部多余毛发的一种有效而安全的方法,即使是肤色较深的人也不例外。我们还想强调的是,用于评估激光脱毛效果的毛囊镜检查是一种最新的、无创的、简单的工具,但却未得到充分利用。我们的研究没有发现严重的不良反应。
{"title":"Efficacy and safety of diode laser for facial hair reduction in hirsutism—a clinico-trichoscopic evaluation","authors":"S. Rafi, Anil Budania, Abhishek Bhardwaj, Saurabh Singh, A. Bains, Benetta Benny, Afroz Alam, Kannan Karthick, Akriti Agarwal, Y. Pathania","doi":"10.4103/jcas.jcas_63_23","DOIUrl":"https://doi.org/10.4103/jcas.jcas_63_23","url":null,"abstract":"Hirsutism is the presence of excessive terminal hair on androgen-dependent sites of the body. Lasers like Alexandrite, diode, and Nd:Yag lasers have been used for hair reduction with varying efficacy. Trichoscopy of hair is a simple noninvasive method of hair assessment. However, it has not been used in the assessment of diode laser hair reduction. This study aimed to assess the efficacy and safety of diode laser hair reduction in skin color with the help of clinical and trichoscopic assessment. This prospective observational study included 73 patients of hirsutism recruited in 18-month period. All participants received sessions of 805nm diode laser at monthly intervals up to six sessions. Clinical and trichoscopic evaluation along with photographs were obtained at each visit. Side effects, if any, were noted in every sitting. All patients were females of Fitzpatrick skin types III–V. All clinical parameters showed statistically significant hair reduction when compared with baseline. Trichoscopic parameters of hair reduction like total hair count, terminal hair count, and terminal/vellus hair ratio showed reduction compared to baseline which was statistically significant (P < 0.05). The most common side effect noted in our study was pain followed by erythema and perifollicular edema. Diode laser is an effective and safe procedure for the reduction of unwanted facial hair, even in darker skin types. We also wish to emphasize that trichoscopy for the assessment of laser hair reduction is a recent, noninvasive, simple, and underutilized tool. No serious adverse events were noted in our study.","PeriodicalId":15415,"journal":{"name":"Journal of Cutaneous and Aesthetic Surgery","volume":"48 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139206882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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Journal of Cutaneous and Aesthetic Surgery
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