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Giant neglected unresectable ulcerated basal cell carcinoma of face: Radiotherapy at rescue 面部巨大的被忽视的无法切除的溃疡性基底细胞癌:放射治疗抢救
Q3 Medicine Pub Date : 2023-11-30 DOI: 10.4103/jcas.jcas_62_23
Shubham Kumar, S. Patra, Bharti Devnani, Varun Rajagopalan, Maninder Kaur
Basal cell carcinomas are typically considered indolent and slowly progressing tumors, but giant basal cell carcinomas are more aggressive with more risk of invasion and poor prognosis. management of such giant BCCs is difficult due to difficulty in surgical approach. we hereby reporting a case of giant ulcerated BCC of face treated with radiotherapy as a rescue treatment.
基底细胞癌通常被认为是进展缓慢的轻度肿瘤,但巨型基底细胞癌更具侵袭性,侵袭风险更高,预后较差。
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引用次数: 0
The effect of combining humic and fulvic acids poultice on wound healing in male rats 腐植酸和富勒酸混合膏药对雄性大鼠伤口愈合的影响
Q3 Medicine Pub Date : 2023-11-30 DOI: 10.4103/jcas.jcas_92_23
N. Gheibi, Fatemeh Samiee-Rad, M. Sofiabadi, Ebrahim Mosayebi, Zahra Shalbaf
Finding new compounds to accelerate wound healing is critical today. Humic substances or fulvic acid each have anti-inflammatory properties. The purpose of this study is to determine the effects of poultice 0.5% containing humic and fulvic acids on wound healing in male rats. An animal model was arranged by making a full-thickness skin wound was created in each rat. Animals were randomly divided into control, sham, and treatment groups. To investigate the effect of humic and fulvic acids combining poultice, the wound area and histological analyses of the number of inflammatory cells, fibroblasts, and angiogenesis were evaluated for 21 days. The animals in the treated group showed higher wound healing percentage, angiogenesis, and fibroblast distribution compared with the control (P < 0.001). Moreover, the topical administration of humic and fulvic acids 0.5% poultice decreased the mean number of inflammatory cells significantly than the other groups (P < 0.001). The topical administration of a poultice containing humic and fulvic acid accelerated wound healing by increasing angiogenesis and fibroblast and reducing inflammatory cell distribution in a rat model.
如今,寻找加速伤口愈合的新化合物至关重要。腐殖质或富勒酸都具有抗炎特性。 本研究旨在确定含腐植酸和富勒酸的 0.5% 膏药对雄性大鼠伤口愈合的影响。 研究安排了一个动物模型,为每只大鼠制作了一个全厚皮肤伤口。动物被随机分为对照组、假治疗组和治疗组。为了研究腐植酸和富勒酸复合膏药的效果,对伤口面积和炎症细胞、成纤维细胞数量及血管生成的组织学分析进行了为期 21 天的评估。 与对照组相比,治疗组动物的伤口愈合率、血管生成和成纤维细胞分布均高于对照组(P < 0.001)。此外,腐植酸和富勒酸 0.5%膏药外敷组比其他组明显减少了炎症细胞的平均数量(P < 0.001)。 在大鼠模型中,通过增加血管生成和成纤维细胞以及减少炎症细胞分布,局部使用含腐植酸和富勒酸的膏药可加速伤口愈合。
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引用次数: 0
Malignant proliferating trichilemmal tumor in male: A rare case entity with diagnostic dilemma 男性恶性增生性三叶虫瘤:诊断困难的罕见病例实体
Q3 Medicine Pub Date : 2023-11-30 DOI: 10.4103/jcas.jcas_90_23
Gulab D Yadav, Prem Shanker, Shubham Singh, Avishek Koley
Trichilemmal tumor is a rare hair follicle tumor that is, thought to occur from a malignant transformation of a benign trichilemmoma. The tumor develops from the outer root sheath of the hair follicle. The patient underwent a wide local excision with 1 cm clear margin. The defect was covered by split thick skin graft harvested from ipsilateral thigh after consulting the plastic surgery department. Trichilemmal cyst can be misdiagnosed as other cutaneous lesions. Like in our case, initial FNAC was suggestive of a epidermoid cyst but post excision Histopathological examination gave us the real picture of a trichilemmal tumor. Recurrent tumors are very rare and can get misdiagnosed as squamous cell carcinoma. Malignant proliferating trichilemmal tumors are rare cutaneous tumors that are very rare in males. These tumors can be misdiagnosed as squamous cell carcinoma and require external stimuli for malignant conversion from benign counterparts. Wide local excision is sufficient for treatment.
三毛瘤是一种罕见的毛囊肿瘤,被认为是由良性三毛瘤恶性转化而来。肿瘤从毛囊外根鞘处生长。患者接受了局部大范围切除术,边缘清晰 1 厘米。在咨询整形外科后,从同侧大腿上采集的厚皮瓣移植覆盖了缺损处。三叶虫囊肿可能被误诊为其他皮肤病变。就像我们的病例一样,最初的FNAC检查提示为表皮样囊肿,但切除后的组织病理学检查却让我们看到了三鳃膜肿瘤的真实面目。复发性肿瘤非常罕见,可能会被误诊为鳞状细胞癌。恶性增生性三基底膜瘤是一种罕见的皮肤肿瘤,在男性中非常罕见。这些肿瘤可能被误诊为鳞状细胞癌,需要外部刺激才能从良性肿瘤转化为恶性肿瘤。治疗时只需局部广泛切除即可。
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引用次数: 0
Efficacy of autologous platelet rich plasma with subcision vs platelet rich plasma with microneedling in atrophic acne scars: A single-center, prospective, intra-individual split-face comparative study 萎缩性痤疮疤痕的自体富血小板血浆亚切术与富血小板血浆微针疗法的疗效对比:单中心、前瞻性、个体内分面比较研究
Q3 Medicine Pub Date : 2023-11-30 DOI: 10.4103/jcas.jcas_218_22
M. Yadav, P. Soni, B. Ghiya, R. Mehta, A. Arora, V. Jangir, Rajesh Khokhar, S. Pareek
Severe post-acne scarring has been implicated as a cause of considerable psychological distress, mainly among adolescents. Subcision and microneedling are cutting-edge treatment options available nowadays. In this study, we aimed to compare the efficacy of microneedling with platelet-rich plasma (PRP) against subcision with PRP in treating atrophic post-acne scars in a split-face study design. Fifty patients with atrophic post-acne facial scars were included in this prospective interventional study. Group A included the left side of the face managed by microneedling with PRP and group B included the right side of the face that was subjected to subcision with PRP. Results were assessed based on Goodman and Baron qualitative and quantitative grading. In our study, at the end of the treatment, on the left side, 5 (10%) had 1 grade of improvement showing good response, 35 (70%) had 2 grades of improvement showing very good response, and 10 (20%) had 3 grades of improvement showing excellent response. On the right side, 1 (2%) patient had no improvement in acne grade showing poor response, 9 (18%) had 1 grade of improvement showing good response, 25 (50%) had 2 grades of improvement showing very good response, whereas 15 (30%) had 3 grades of improvement showing excellent response. Till date, apart from ours no other study has compared the two modalities head-to-head with adjuvant PRP in both groups. Although both modalities showed statistically significant results individually, there was no significant difference in qualitative improvement of acne scars between the two groups.
严重的痤疮后瘢痕已被认为是造成相当大的心理压力的原因,主要是在青少年中。皮下注射和微针疗法是当今最先进的治疗方法。 在本研究中,我们采用分面研究设计,旨在比较富血小板血浆(PRP)微针疗法与富血小板血浆亚切削疗法治疗萎缩性痤疮后疤痕的疗效。 这项前瞻性干预研究共纳入了 50 名萎缩性痤疮后面部疤痕患者。A 组包括采用 PRP 微针疗法的左侧面部,B 组包括采用 PRP 亚切口疗法的右侧面部。结果根据古德曼和巴伦的定性和定量分级进行评估。 在我们的研究中,治疗结束时,左侧脸部有 5 人(10%)改善了 1 个等级,显示反应良好;35 人(70%)改善了 2 个等级,显示反应非常好;10 人(20%)改善了 3 个等级,显示反应极佳。在右侧,1 名患者(2%)的痤疮等级没有改善,显示反应较差;9 名患者(18%)的痤疮等级改善了 1 级,显示反应良好;25 名患者(50%)的痤疮等级改善了 2 级,显示反应非常好;而 15 名患者(30%)的痤疮等级改善了 3 级,显示反应极佳。 迄今为止,除了我们的研究外,还没有其他研究对这两种模式进行过正面比较,并在两组中都使用了 PRP 辅助治疗。虽然这两种方法在统计学上都显示出显著的效果,但两组在痤疮疤痕的质量改善方面没有明显差异。
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引用次数: 0
Anaphylactic reaction to hyaluronidase use for a complication of lip augmentation with hyaluronic acid 透明质酸丰唇并发症中使用透明质酸酶引起的过敏反应
Q3 Medicine Pub Date : 2023-11-30 DOI: 10.4103/jcas.jcas_99_23
Gisela Seyboth Wild, L. Palma, Susana Morimoto, Priscilla Aparecida Pereira
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引用次数: 0
Single-prick local anesthesia for sebaceous cyst excision 皮脂腺囊肿切除术的单刺局部麻醉
Q3 Medicine Pub Date : 2023-11-30 DOI: 10.4103/jcas.jcas_223_22
Tabassum Mulla, Tushar Jadhav, Nalini Thakur, Ananta Kulkarni
Sebaceous cyst excision is a commonly performed outpatient surgery. Patients are often concerned about intraoperative pain associated with multiple pricks while injecting local anesthesia. Injection of an anesthetic agent with a single prick is reassuring to the patient and encourages the patient to cooperate with the surgeon during rest of the procedure.
皮脂腺囊肿切除术是一种常见的门诊手术。患者通常担心在注射局部麻醉剂时,术中会出现多次刺痛。单刺注射麻醉剂可让患者放心,并鼓励患者在手术的其他部分与外科医生合作。
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引用次数: 0
Efficacy and safety of diode laser for facial hair reduction in hirsutism—a clinico-trichoscopic evaluation 多毛症患者使用二极管激光减少面部毛发的有效性和安全性--临床-腹腔镜评估
Q3 Medicine Pub Date : 2023-11-30 DOI: 10.4103/jcas.jcas_63_23
S. Rafi, Anil Budania, Abhishek Bhardwaj, Saurabh Singh, A. Bains, Benetta Benny, Afroz Alam, Kannan Karthick, Akriti Agarwal, Y. Pathania
Hirsutism is the presence of excessive terminal hair on androgen-dependent sites of the body. Lasers like Alexandrite, diode, and Nd:Yag lasers have been used for hair reduction with varying efficacy. Trichoscopy of hair is a simple noninvasive method of hair assessment. However, it has not been used in the assessment of diode laser hair reduction. This study aimed to assess the efficacy and safety of diode laser hair reduction in skin color with the help of clinical and trichoscopic assessment. This prospective observational study included 73 patients of hirsutism recruited in 18-month period. All participants received sessions of 805nm diode laser at monthly intervals up to six sessions. Clinical and trichoscopic evaluation along with photographs were obtained at each visit. Side effects, if any, were noted in every sitting. All patients were females of Fitzpatrick skin types III–V. All clinical parameters showed statistically significant hair reduction when compared with baseline. Trichoscopic parameters of hair reduction like total hair count, terminal hair count, and terminal/vellus hair ratio showed reduction compared to baseline which was statistically significant (P < 0.05). The most common side effect noted in our study was pain followed by erythema and perifollicular edema. Diode laser is an effective and safe procedure for the reduction of unwanted facial hair, even in darker skin types. We also wish to emphasize that trichoscopy for the assessment of laser hair reduction is a recent, noninvasive, simple, and underutilized tool. No serious adverse events were noted in our study.
多毛症是指人体依赖雄激素的部位出现过多的末端毛发。亚历山大激光器、二极管激光器和掺钕钇钕石榴石激光器等激光器已被用于减少毛发,但效果不一。毛发三频扫描是一种简单的非侵入性毛发评估方法。然而,这种方法尚未用于二极管激光脱毛的评估。 本研究旨在通过临床和三腔镜评估,评估二极管激光脱毛对肤色的有效性和安全性。 这项前瞻性观察研究在 18 个月内招募了 73 名多毛症患者。所有参与者每月接受一次 805nm 二极管激光治疗,最多六次。每次就诊时都要进行临床和三镜检查,并拍摄照片。每次就诊都会记录副作用(如有)。 所有患者均为女性,皮肤类型为 Fitzpatrick III-V。与基线相比,所有临床参数均显示毛发明显减少。毛发减少的三镜参数,如总毛发数、末端毛发数和末端/绒毛比率,与基线相比均有减少,且有统计学意义(P < 0.05)。在我们的研究中,最常见的副作用是疼痛,其次是红斑和毛囊周围水肿。 二极管激光是减少面部多余毛发的一种有效而安全的方法,即使是肤色较深的人也不例外。我们还想强调的是,用于评估激光脱毛效果的毛囊镜检查是一种最新的、无创的、简单的工具,但却未得到充分利用。我们的研究没有发现严重的不良反应。
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引用次数: 0
Use of monopolar and bipolar radiofrequency probes for treatment of cutaneous leiomyoma 使用单极和双极射频探针治疗皮肤良性肌瘤
Q3 Medicine Pub Date : 2023-11-30 DOI: 10.4103/jcas.jcas_78_23
Shivani Bansal, Sushama Sushama, A. Brar, M. Rana
Cutaneous leiomyomas are tumors of smooth muscle origin which appear as erythematous papules and nodules that are mostly painful to touch. Although surgical excision is the gold standard treatment, other destructive methods such as electrodessication, cryotherapy or carbon-dioxide laser may also be done for cure. Our patient presented with painful cutaneous leiyomyomas which resolved well with radiofrequency ablation done with two different techniques using monopolar and bipolar radiofrequency probes. There was no recurrence at 8 months follow-up.
皮肤平滑肌瘤是一种平滑肌源性肿瘤,表现为红斑丘疹和结节,大多触痛。虽然手术切除是治疗的金标准,但也可采用其他破坏性方法,如电解、冷冻或二氧化碳激光治疗。我们的患者患有疼痛性皮肤白肌瘤,在使用单极和双极射频探头的两种不同技术进行射频消融后,症状得到了很好的缓解。在 8 个月的随访中没有复发。
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引用次数: 0
A clinico-epidemiological study of different dermoscopic patterns in hyperpigmented facial lesions in a tertiary care centre 对一家三级医疗中心面部色素沉着病变不同皮肤镜模式的临床流行病学研究
Q3 Medicine Pub Date : 2023-11-30 DOI: 10.4103/jcas.jcas_48_23
Vikas Solanki, A. Dongre, C. Nayak
Facial pigmentation is a common presentation of patients attending dermatology out patient department (OPD) and is of great concern to patients. Facial pigmentation may be multifactorial and is only rarely diagnosed accurately by a detailed history and clinical examination. Pigmentary disorders cause psychological distress and negatively impact the quality of life of an individual. (1) To study different dermoscopic patterns in facial melanosis. (2) To estimate the frequency of different dermoscopic patterns. Patients with facial hyperpigmentation attending the dermatology OPD were recruited after taking their written consent. A detailed history was taken to collect demographic data. Clinical examination and dermoscopy were done in all patients. Biopsy was done as and when required. Descriptive statistics has been used to describe the quantitative data. Qualitative data were presented as frequency and percentage for clinical and dermoscopic patterns. The study included 100 patients with 15 different facial melanoses. The most common age group affected was 21–40 years in 53 (53%) cases. The female-to-male ratio was 1.63:1. Melasma was reported as the most common cause of facial melanosis constituting 49 (49%) of the total cases. Out of the total melasma cases, epidermal melasma constituted 22 (45%) cases, dermal melasma constituted four (4%) cases and mixed melasma constituted 23 (47%) cases. Other cases included were lichen planus pigmentosus (14; 14%), facial acanthosis nigricans (14; 14%), periorbital hyperpigmentation (7; 7%), post-inflammatory hyperpigmentation (4; 4%), exogenous ochronosis (2; 2%), lentigines (2; 2%), frictional melanosis (2;2%), and one case each of Becker’s nevus, nevus of Ota, olanzapine-induced hyperpigmentation, Riehl’s melanosis, macular amyloidosis, and tanning. Melasma was reported as the most common cause of facial melanosis. The most common dermoscopic feature was accentuated pseudopigment network. The study is beneficial in understanding the different clinical and dermoscopic patterns of facial melanosis, thus helping the physician to effectively manage the conditions and reduce the need of biopsy. (1) A small sample size. (2) Histopathological correlation was not done in all cases.
面部色素沉着是皮肤科门诊部(OPD)就诊患者的常见病,也是患者非常关心的问题。面部色素沉着可能是由多种因素引起的,很少能通过详细的病史和临床检查得到准确诊断。色素性疾病会造成心理困扰,对个人的生活质量产生负面影响。 (1) 研究面部黑色素沉着症的不同皮肤镜模式。(2) 估计不同皮肤镜模式的出现频率。 在征得患者的书面同意后,招募他们到皮肤科门诊就诊,以了解面部色素沉着症患者的情况。详细询问病史以收集人口统计学数据。对所有患者进行临床检查和皮肤镜检查。必要时进行活组织检查。描述性统计用于描述定量数据。定性数据以临床和皮肤镜检查模式的频率和百分比表示。 研究包括 100 名患有 15 种不同面部黑色素瘤的患者。最常见的患病年龄段为 21-40 岁,占 53 例(53%)。女性与男性的比例为 1.63:1。据报告,黄褐斑是导致面部黑色素沉着的最常见原因,占总病例数的 49(49%)。在所有黄褐斑病例中,表皮型黄褐斑占 22 例(45%),真皮型黄褐斑占 4 例(4%),混合型黄褐斑占 23 例(47%)。其他病例包括色素沉着性扁平苔藓(14;14%)、面部黑棘皮病(14;14%)、眶周色素沉着(7;7%)、炎症后色素沉着(4;4%)、外源性色素沉着(2;2%)、雀斑(2;2%)、摩擦性黑变病(2;2%),以及贝克尔痣、太田痣、奥氮平诱导的色素沉着、Riehl 黑变病、黄斑淀粉样变性和日光浴各一例。 据报告,黄褐斑是导致面部黑变病的最常见原因。最常见的皮肤镜特征是突出的假性色素网络。这项研究有助于了解面部黑色素沉着症的不同临床和皮肤镜模式,从而帮助医生有效地管理病情,减少活组织检查的需要。 (1)样本量较小。(2)并非所有病例都进行了组织病理学相关分析。
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引用次数: 0
Treatment of localized granuloma annulare with the 595-nm pulsed dye laser 用 595 纳米脉冲染料激光治疗局部环状肉芽肿
Q3 Medicine Pub Date : 2023-11-30 DOI: 10.4103/jcas.jcas_116_23
Catarina Correia, Isabel Correia-Fonseca, P. Filipe
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引用次数: 0
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Journal of Cutaneous and Aesthetic Surgery
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