首页 > 最新文献

Journal of Clinical Medicine Research最新文献

英文 中文
Effect of Reality Oriented Training Combined with Group Diversified Art Therapy on Social Function of Chronic Schizophrenia 现实导向训练与小组多元化艺术疗法相结合对慢性精神分裂症患者社会功能的影响
Pub Date : 2024-07-05 DOI: 10.32629/jcmr.v5i2.2327
Jianqian Feng, Huoliang Chen, Li Fu
Objective: To explore the effect of reality oriented training combined with Group diversified art therapy on social function of patients with chronic schizophrenia. Methods: 60 patients with chronic schizophrenia who were hospitalized for a long time in our hospital were selected for the implementation of reality oriented training combined with Group diversified art therapy. The activities of daily living, social function and rehabilitation scores of patients before and after the implementation were compared. Results: after intervention, ADL score, SDSS score and IPROS score were significantly decreased (p<0.05). Conclusion: the implementation of reality oriented training combined with Group diversified art therapy for patients with chronic schizophrenia can improve the daily living ability and social function of patients, and promote the better recovery of patients.
目的探讨现实导向训练结合团体多元化艺术治疗对慢性精神分裂症患者社会功能的影响。方法:选取我院长期住院的 60 名慢性精神分裂症患者为研究对象,实施现实导向训练联合小组多元化艺术治疗。比较实施前后患者的日常生活活动、社会功能和康复评分。结果:干预后,ADL 评分、SDSS 评分和 IPROS 评分均明显下降(P<0.05)。结论:对慢性精神分裂症患者实施现实导向训练结合小组多元化艺术治疗,可以提高患者的日常生活能力和社会功能,促进患者更好地康复。
{"title":"Effect of Reality Oriented Training Combined with Group Diversified Art Therapy on Social Function of Chronic Schizophrenia","authors":"Jianqian Feng, Huoliang Chen, Li Fu","doi":"10.32629/jcmr.v5i2.2327","DOIUrl":"https://doi.org/10.32629/jcmr.v5i2.2327","url":null,"abstract":"Objective: To explore the effect of reality oriented training combined with Group diversified art therapy on social function of patients with chronic schizophrenia. Methods: 60 patients with chronic schizophrenia who were hospitalized for a long time in our hospital were selected for the implementation of reality oriented training combined with Group diversified art therapy. The activities of daily living, social function and rehabilitation scores of patients before and after the implementation were compared. Results: after intervention, ADL score, SDSS score and IPROS score were significantly decreased (p<0.05). Conclusion: the implementation of reality oriented training combined with Group diversified art therapy for patients with chronic schizophrenia can improve the daily living ability and social function of patients, and promote the better recovery of patients.","PeriodicalId":15431,"journal":{"name":"Journal of Clinical Medicine Research","volume":" 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141674733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical Evaluation of Xpert Xpress SARS-CoV-2/Flu/RSV Combination Test in China Xpert Xpress SARS-CoV-2/流感/RSV联合检测试剂盒在中国的临床评估
Pub Date : 2024-07-05 DOI: 10.32629/jcmr.v5i2.2314
Lei Chen, Zhaobao Pan, Yuanyuan Tang, Jifei Cai, Xiaoying He
During influenza season, the influenza virus and respiratory syncytial virus (RSV) can cause severe respiratory infections. The clinical manifestation of symptoms caused by COVID-19, influenza virus and RSV are very similar.We conducted the performance characteristics of the Xpert Xpress SARS-CoV-2/Flu/RSV combined assay in China and came up with the detection results of the two detection methods are almost the same for all targets, and the consistency rate is close to 100%.This indicates that the assay is of great clinical value for distinguishing infections caused by these four viruses.
在流感季节,流感病毒和呼吸道合胞病毒(RSV)可引起严重的呼吸道感染。我们在中国对 Xpert Xpress SARS-CoV-2/Flu/RSV 联合检测法进行了性能测试,结果表明两种检测方法对所有目标物的检测结果基本一致,一致性接近 100%,这表明该检测方法在区分这四种病毒引起的感染方面具有重要的临床价值。
{"title":"Clinical Evaluation of Xpert Xpress SARS-CoV-2/Flu/RSV Combination Test in China","authors":"Lei Chen, Zhaobao Pan, Yuanyuan Tang, Jifei Cai, Xiaoying He","doi":"10.32629/jcmr.v5i2.2314","DOIUrl":"https://doi.org/10.32629/jcmr.v5i2.2314","url":null,"abstract":"During influenza season, the influenza virus and respiratory syncytial virus (RSV) can cause severe respiratory infections. The clinical manifestation of symptoms caused by COVID-19, influenza virus and RSV are very similar.We conducted the performance characteristics of the Xpert Xpress SARS-CoV-2/Flu/RSV combined assay in China and came up with the detection results of the two detection methods are almost the same for all targets, and the consistency rate is close to 100%.This indicates that the assay is of great clinical value for distinguishing infections caused by these four viruses.","PeriodicalId":15431,"journal":{"name":"Journal of Clinical Medicine Research","volume":" 48","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141675707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of Dietary Carotenoids and Lutein on Eye Health Maintenance in Elderly People 膳食类胡萝卜素和叶黄素对维护老年人眼睛健康的影响
Pub Date : 2024-07-05 DOI: 10.32629/jcmr.v5i2.2302
Yongshuai Zhang, Ying Li
This study aimed to explore the maintenance effect of dietary carotenoids and lutein on the eye health of elderly people. By analyzing the types and characteristics of carotenoids, as well as the characteristics of lutein and its interaction with carotenoids, we have studied their mechanism of action in eye health. Further, we discussed in detail the specific effects of dietary carotenoids and lutein on the eye health of older people, including the prevention of macular degeneration and other senile eye diseases, the improvement of vision, and the impact on light sensitivity. In order to help the elderly effectively take in these nutrients, we provide suggestions on the selection and use of foods containing carotenoids and lutein, as well as suggestions and precautions for dietary plans. Finally, through a case study, we show the positive impact of adopting good diet and supplement strategies on eye health in a real case.
本研究旨在探讨膳食中类胡萝卜素和叶黄素对老年人眼睛健康的维护作用。通过分析类胡萝卜素的种类和特点,以及叶黄素的特点及其与类胡萝卜素的相互作用,我们研究了它们对眼睛健康的作用机制。此外,我们还详细讨论了膳食中的类胡萝卜素和叶黄素对老年人眼睛健康的具体影响,包括预防黄斑变性和其他老年性眼病、改善视力以及对光敏感性的影响。为了帮助老年人有效地摄取这些营养素,我们就如何选择和使用含有类胡萝卜素和叶黄素的食物提出了建议,并就膳食计划提出了建议和注意事项。最后,我们通过一个案例研究,展示了采取良好的饮食和补充策略对眼睛健康的积极影响。
{"title":"Effect of Dietary Carotenoids and Lutein on Eye Health Maintenance in Elderly People","authors":"Yongshuai Zhang, Ying Li","doi":"10.32629/jcmr.v5i2.2302","DOIUrl":"https://doi.org/10.32629/jcmr.v5i2.2302","url":null,"abstract":"This study aimed to explore the maintenance effect of dietary carotenoids and lutein on the eye health of elderly people. By analyzing the types and characteristics of carotenoids, as well as the characteristics of lutein and its interaction with carotenoids, we have studied their mechanism of action in eye health. Further, we discussed in detail the specific effects of dietary carotenoids and lutein on the eye health of older people, including the prevention of macular degeneration and other senile eye diseases, the improvement of vision, and the impact on light sensitivity. In order to help the elderly effectively take in these nutrients, we provide suggestions on the selection and use of foods containing carotenoids and lutein, as well as suggestions and precautions for dietary plans. Finally, through a case study, we show the positive impact of adopting good diet and supplement strategies on eye health in a real case.","PeriodicalId":15431,"journal":{"name":"Journal of Clinical Medicine Research","volume":" 30","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141673331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploring Therapeutic Strategies for Tumour Stem Cells in Digestive Tract Tumours 探索消化道肿瘤中肿瘤干细胞的治疗策略
Pub Date : 2024-07-05 DOI: 10.32629/jcmr.v5i2.2334
Xinliu Xu
To explore the potential and challenges of tumour stem cells in the treatment of digestive tract tumours, the article analyses the key role of tumour stem cells in tumourigenesis and treatment resistance using a systematic review as an approach. Tumour stem cells are capable of self-renewal and multidirectional differentiation, which have a significant impact on long-term tumour survival and recurrence. Therapeutic strategies for targeting tumour stem cells include labelling and isolation techniques as well as the development of targeted drugs aimed at improving therapeutic efficacy and prolonging patient survival. However, therapeutic resistance caused by tumour stem cells remains one of the challenges and requires further in-depth studies and effective therapeutic strategies, providing theoretical support for future clinical studies and the development of individualized treatment protocols.
为了探索肿瘤干细胞在消化道肿瘤治疗中的潜力和挑战,文章以系统综述为方法,分析了肿瘤干细胞在肿瘤发生和治疗耐药性中的关键作用。肿瘤干细胞具有自我更新和多向分化的能力,对肿瘤的长期存活和复发有重要影响。针对肿瘤干细胞的治疗策略包括标记和分离技术以及靶向药物的开发,旨在提高疗效和延长患者生存期。然而,肿瘤干细胞导致的治疗耐药性仍是挑战之一,需要进一步深入研究和有效的治疗策略,为未来的临床研究和个体化治疗方案的开发提供理论支持。
{"title":"Exploring Therapeutic Strategies for Tumour Stem Cells in Digestive Tract Tumours","authors":"Xinliu Xu","doi":"10.32629/jcmr.v5i2.2334","DOIUrl":"https://doi.org/10.32629/jcmr.v5i2.2334","url":null,"abstract":"To explore the potential and challenges of tumour stem cells in the treatment of digestive tract tumours, the article analyses the key role of tumour stem cells in tumourigenesis and treatment resistance using a systematic review as an approach. Tumour stem cells are capable of self-renewal and multidirectional differentiation, which have a significant impact on long-term tumour survival and recurrence. Therapeutic strategies for targeting tumour stem cells include labelling and isolation techniques as well as the development of targeted drugs aimed at improving therapeutic efficacy and prolonging patient survival. However, therapeutic resistance caused by tumour stem cells remains one of the challenges and requires further in-depth studies and effective therapeutic strategies, providing theoretical support for future clinical studies and the development of individualized treatment protocols.","PeriodicalId":15431,"journal":{"name":"Journal of Clinical Medicine Research","volume":" 17","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141676692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Meta-analysis of In-stent Restenosis Factors after Coronary Intervention 冠状动脉介入术后支架内再狭窄因素的 Meta 分析
Pub Date : 2024-07-05 DOI: 10.32629/jcmr.v5i2.2324
Liqing Gao, Hengjin Dong
This aim is to explore the relevant factors affecting in-stent restenosis after coronary intervention procedures. Relevant research literature was searched through domestic and international databases and Meta-analysis was performed. Smoking, alcohol consumption, hypertension, hyperlipidemia, diabetes mellitus, low-density lipoprotein cholesterol, total cholesterol, triglycerides, uric acid level, number of implanted stents, and stent length were significantly associated with in-stent restenosis (P<0.05). Factors such as gender, age, body mass index, high-density lipoprotein cholesterol, and left ventricular ejection fraction were not significantly correlated with in-stent restenosis (P>0.05).
本研究旨在探讨影响冠状动脉介入手术后支架内再狭窄的相关因素。通过国内外数据库检索相关研究文献,并进行 Meta 分析。吸烟、饮酒、高血压、高脂血症、糖尿病、低密度脂蛋白胆固醇、总胆固醇、甘油三酯、尿酸水平、植入支架数量和支架长度与支架内再狭窄显著相关(P0.05)。
{"title":"Meta-analysis of In-stent Restenosis Factors after Coronary Intervention","authors":"Liqing Gao, Hengjin Dong","doi":"10.32629/jcmr.v5i2.2324","DOIUrl":"https://doi.org/10.32629/jcmr.v5i2.2324","url":null,"abstract":"This aim is to explore the relevant factors affecting in-stent restenosis after coronary intervention procedures. Relevant research literature was searched through domestic and international databases and Meta-analysis was performed. Smoking, alcohol consumption, hypertension, hyperlipidemia, diabetes mellitus, low-density lipoprotein cholesterol, total cholesterol, triglycerides, uric acid level, number of implanted stents, and stent length were significantly associated with in-stent restenosis (P<0.05). Factors such as gender, age, body mass index, high-density lipoprotein cholesterol, and left ventricular ejection fraction were not significantly correlated with in-stent restenosis (P>0.05).","PeriodicalId":15431,"journal":{"name":"Journal of Clinical Medicine Research","volume":" 19","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141673289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advances in Targeted Therapy of Non-small Cell Lung Cancer with EGFR Combined With P53 Gene Mutation 表皮生长因子受体结合 P53 基因突变的非小细胞肺癌靶向治疗进展
Pub Date : 2024-07-05 DOI: 10.32629/jcmr.v5i2.2316
Di Lu, Yueyong Li, Ju Liao, Wenxian Lin, Xiuli Mao, Xinxin Wei, Xiaohong Qin
Non-small cell lung cancer (NSCLC) is currently the leading cause of cancer death worldwide. NSCLC patients with epidermal growth factor receptor (EGFR) mutations were treated with EGFR-tyrosine kinase inhibitor (TKI), but EGFR mutations combined with other genes had a shorter survival. However, the P53 gene mutation is a common combined mutation in patients with NSCLC with EGFR gene mutation. This review summarizes the development of targeted NSCLC for EGFR with P53 mutations.
非小细胞肺癌(NSCLC)是目前全球癌症死亡的主要原因。表皮生长因子受体(EGFR)突变的非小细胞肺癌患者可接受EGFR-酪氨酸激酶抑制剂(TKI)治疗,但EGFR突变合并其他基因的患者生存期较短。然而,P53 基因突变是伴有 EGFR 基因突变的 NSCLC 患者中常见的合并突变。本综述总结了针对 EGFR 基因突变合并 P53 基因突变的 NSCLC 靶向药物的发展情况。
{"title":"Advances in Targeted Therapy of Non-small Cell Lung Cancer with EGFR Combined With P53 Gene Mutation","authors":"Di Lu, Yueyong Li, Ju Liao, Wenxian Lin, Xiuli Mao, Xinxin Wei, Xiaohong Qin","doi":"10.32629/jcmr.v5i2.2316","DOIUrl":"https://doi.org/10.32629/jcmr.v5i2.2316","url":null,"abstract":"Non-small cell lung cancer (NSCLC) is currently the leading cause of cancer death worldwide. NSCLC patients with epidermal growth factor receptor (EGFR) mutations were treated with EGFR-tyrosine kinase inhibitor (TKI), but EGFR mutations combined with other genes had a shorter survival. However, the P53 gene mutation is a common combined mutation in patients with NSCLC with EGFR gene mutation. This review summarizes the development of targeted NSCLC for EGFR with P53 mutations.","PeriodicalId":15431,"journal":{"name":"Journal of Clinical Medicine Research","volume":" 18","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141675654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Comprehensive Impact of Maintenance Hemodialysis Treatment: a Qualitative Study 维持性血液透析治疗的综合影响:一项定性研究
Pub Date : 2024-07-05 DOI: 10.32629/jcmr.v5i2.2312
Qin Guan, Hongfei Yang, Lu Zhou, Zhipeng Xue, Xiaoling Zhu
Objective: To investigate the comprehensive impact of maintenance hemodialysis treatment on patients and their families, in order to improve their quality of life and enhance treatment effectiveness. Method: Colaizzi phenomenological analysis is used to analyze data and extract themes. Results: The comprehensive impact of maintenance hemodialysis treatment can be summarized into five themes: decreased work ability, disease restriction of life freedom, decreased physical function, decreased quality of life, and increased family burden. Conclusion: Hemodialysis has a significant impact on patients and their families, with economic, physical, and psychological impacts, directly reducing their quality of life. It is recommended to adopt multidimensional strategies to improve the quality of life and treatment outcomes of patients.
目的调查维持性血液透析治疗对患者及其家属的综合影响,以改善他们的生活质量,提高治疗效果。方法:采用科莱兹现象学分析法分析数据并提取主题:采用科莱兹现象学分析法分析数据并提取主题。结果维持性血液透析治疗的综合影响可归纳为五个主题:工作能力下降、疾病限制生活自由、身体功能下降、生活质量下降和家庭负担加重。结论血液透析对患者及其家庭产生了重大影响,包括经济、身体和心理影响,直接降低了患者的生活质量。建议采取多维策略,改善患者的生活质量和治疗效果。
{"title":"The Comprehensive Impact of Maintenance Hemodialysis Treatment: a Qualitative Study","authors":"Qin Guan, Hongfei Yang, Lu Zhou, Zhipeng Xue, Xiaoling Zhu","doi":"10.32629/jcmr.v5i2.2312","DOIUrl":"https://doi.org/10.32629/jcmr.v5i2.2312","url":null,"abstract":"Objective: To investigate the comprehensive impact of maintenance hemodialysis treatment on patients and their families, in order to improve their quality of life and enhance treatment effectiveness. Method: Colaizzi phenomenological analysis is used to analyze data and extract themes. Results: The comprehensive impact of maintenance hemodialysis treatment can be summarized into five themes: decreased work ability, disease restriction of life freedom, decreased physical function, decreased quality of life, and increased family burden. Conclusion: Hemodialysis has a significant impact on patients and their families, with economic, physical, and psychological impacts, directly reducing their quality of life. It is recommended to adopt multidimensional strategies to improve the quality of life and treatment outcomes of patients.","PeriodicalId":15431,"journal":{"name":"Journal of Clinical Medicine Research","volume":" 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141673623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Meta-analysis of Intensive and Standard Antihypertensive Safety in Elderly Hypertensive Patients 老年高血压患者强化和标准降压安全性的 Meta 分析
Pub Date : 2024-07-05 DOI: 10.32629/jcmr.v5i2.2318
Chao Fang, Nuan Xiao, Jiannan Wu, Yuanxin Tian, Hongmei Zhao, Simin Ren
Objective: To evaluate the effect of intensive and standard antihypertensive pressure on cardiovascular and cerebrovascular events, serious adverse events and all-cause deaths in elderly hypertensive patients. Methods: Pubmed, Embase, Cochrane, CNKI, Wanfang and CBM databases were searched. All of the included studies were the RCT trials. Relative risk (RR) and 95% confidence interval (95%CI) were used to evaluate differences in enhanced and standard antihypertensive outcomes. Statistical analysis was applied using the Stata 17.0 software. Results: Seven tests were retrieved to meet the conditions, Different antihypertensive effects showed overall statistical differences in the incidence of cardiovascular and cerebrovascular events, Significant decrease in the intensive antihypertensive group [P=0.000, RR95%CI:0.79(0.69-0.90)], Among them, the incidence of acute myocardial infarction (AMI) and acute coronary syndrome (ACS) was significantly reduced in the intensive antihypertensive group [P=0.000, RR95%CI:0.62(0.48-0.81)], The incidence of stroke events was significantly fewer in the intensive group [P=0.000, RR95%CI:0.62(0.48-0.81)]; There was no significant difference in the incidence of acute HF (AHF) between the two groups [P=0.242, RR95%CI:0.55(0.20-1.50)]. There was no significant statistical difference in the incidence of serious adverse events overall by different antihypertensive criteria [P=0.251,RR95%CI:1.12(0.92-1.36)], of which two groups were eGFR<30ml/min/1.73m2There was no significant statistical difference in the incidence [P=0.280,RR95%CI:1.46(0.74-2.89)], no significant statistical difference in the incidence of orthostatic hypotension [P=0.473,RR95%CI:1.47(0.51-4.23)], no significant statistical difference in the incidence of falls [P=0.607,RR95%CI:1.24(0.54-42.86)], and the incidence of syncope in the intensive antihypertensive group was higher than that in the standard antihypertensive group [P=0.009,RR95%CI:2.43(1.24-4.77)]. There was no significant statistical difference in the effect of different antihypertensive criteria on all-cause death [P=0.156,RR95%CI:0.92(0.81-1.03)]. Conclusion: Compared with the standard antihypertensive in elderly patients with hypertension, there is no significant statistical difference in the incidence of serious adverse events and all-cause mortality in the elderly, and the incidence of cardiovascular and cerebrovascular events in the elderly.
目的评估强化降压和标准降压对老年高血压患者心脑血管事件、严重不良事件和全因死亡的影响。研究方法检索了 Pubmed、Embase、Cochrane、CNKI、万方和 CBM 数据库。所有纳入的研究均为 RCT 试验。使用相对风险(RR)和 95% 置信区间(95%CI)来评估增强型和标准型降压结果的差异。统计分析采用 Stata 17.0 软件。结果不同降压效果对心脑血管事件发生率的总体统计学差异显示,强化降压组显著下降[P=0.000,RR95%CI:0.79(0.69-0. 90)],其中强化降压组心脑血管事件发生率显著下降[P=0.000,RR95%CI:0.79(0.69-0. 90)]。其中,急性心肌梗死(AMI)和急性冠脉综合征(ACS)的发生率在强化降压组明显降低[P=0.000,RR95%CI:0.62(0.48-0.P=0.000,RR95%CI:0.62(0.48-0.81)],强化组卒中事件发生率明显降低[P=0.000,RR95%CI:0.62(0.48-0.81)];两组急性心力衰竭(AHF)发生率无明显差异[P=0.242,RR95%CI:0.55(0.20-1.50)]。不同降压标准严重不良事件发生率总体无明显统计学差异[P=0.251,RR95%CI:1.12(0.92-1.36)],其中两组 eGFR<30ml/min/1.73m2 发生率无明显统计学差异[P=0.280,RR95%CI:1.46(0.74-2.P=0.280,RR95%CI:1.46(0.74-2.89)]、正性低血压发生率无明显统计学差异[P=0.473,RR95%CI:1.47(0.51-4.23)]、跌倒发生率无明显统计学差异[P=0.607,RR95%CI:1.24(0.54-42.86)],强化降压组晕厥发生率高于标准降压组[P=0.009,RR95%CI:2.43(1.24-4.77)]。不同降压标准对全因死亡的影响无明显统计学差异[P=0.156,RR95%CI:0.92(0.81-1.03)]。结论与标准降压相比,老年高血压患者严重不良事件发生率和全因死亡率、老年心脑血管事件发生率无明显统计学差异。
{"title":"A Meta-analysis of Intensive and Standard Antihypertensive Safety in Elderly Hypertensive Patients","authors":"Chao Fang, Nuan Xiao, Jiannan Wu, Yuanxin Tian, Hongmei Zhao, Simin Ren","doi":"10.32629/jcmr.v5i2.2318","DOIUrl":"https://doi.org/10.32629/jcmr.v5i2.2318","url":null,"abstract":"Objective: To evaluate the effect of intensive and standard antihypertensive pressure on cardiovascular and cerebrovascular events, serious adverse events and all-cause deaths in elderly hypertensive patients. Methods: Pubmed, Embase, Cochrane, CNKI, Wanfang and CBM databases were searched. All of the included studies were the RCT trials. Relative risk (RR) and 95% confidence interval (95%CI) were used to evaluate differences in enhanced and standard antihypertensive outcomes. Statistical analysis was applied using the Stata 17.0 software. Results: Seven tests were retrieved to meet the conditions, Different antihypertensive effects showed overall statistical differences in the incidence of cardiovascular and cerebrovascular events, Significant decrease in the intensive antihypertensive group [P=0.000, RR95%CI:0.79(0.69-0.90)], Among them, the incidence of acute myocardial infarction (AMI) and acute coronary syndrome (ACS) was significantly reduced in the intensive antihypertensive group [P=0.000, RR95%CI:0.62(0.48-0.81)], The incidence of stroke events was significantly fewer in the intensive group [P=0.000, RR95%CI:0.62(0.48-0.81)]; There was no significant difference in the incidence of acute HF (AHF) between the two groups [P=0.242, RR95%CI:0.55(0.20-1.50)]. There was no significant statistical difference in the incidence of serious adverse events overall by different antihypertensive criteria [P=0.251,RR95%CI:1.12(0.92-1.36)], of which two groups were eGFR<30ml/min/1.73m2There was no significant statistical difference in the incidence [P=0.280,RR95%CI:1.46(0.74-2.89)], no significant statistical difference in the incidence of orthostatic hypotension [P=0.473,RR95%CI:1.47(0.51-4.23)], no significant statistical difference in the incidence of falls [P=0.607,RR95%CI:1.24(0.54-42.86)], and the incidence of syncope in the intensive antihypertensive group was higher than that in the standard antihypertensive group [P=0.009,RR95%CI:2.43(1.24-4.77)]. There was no significant statistical difference in the effect of different antihypertensive criteria on all-cause death [P=0.156,RR95%CI:0.92(0.81-1.03)]. Conclusion: Compared with the standard antihypertensive in elderly patients with hypertension, there is no significant statistical difference in the incidence of serious adverse events and all-cause mortality in the elderly, and the incidence of cardiovascular and cerebrovascular events in the elderly.","PeriodicalId":15431,"journal":{"name":"Journal of Clinical Medicine Research","volume":" 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141674468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploration of the Optimal Dosage of Remimazolam in Painless Gastrointestinal Endoscopy and Analysis of Its Impact on Patient Comfort 探讨雷马唑仑在无痛胃肠道内窥镜检查中的最佳剂量并分析其对患者舒适度的影响
Pub Date : 2024-07-05 DOI: 10.32629/jcmr.v5i2.2321
Sanjie Gao
Painless gastrointestinal endoscopy, as an important diagnostic technique in modern medicine, is crucial for patient comfort and examination quality. Remimazolam, as a novel sedative drug, has demonstrated promising applications in painless gastrointestinal endoscopy. This article aims to explore the optimal dosage of remimazolam in painless gastrointestinal endoscopy and analyze its impact on patient comfort..By comparing indicators such as sedation depth, recovery time, and incidence of adverse reactions under different dosages, we found that a certain dosage range can maximize patient comfort while ensuring the effectiveness of the examination.Finally, we conducted a thorough analysis of remimazolam within this dosage range, exploring its mechanism of improving patient comfort. The results showed that this dosage range of remimazolam can effectively alleviate patients' anxiety and fear, reduce discomfort during the examination, and thereby improve their overall satisfaction.
无痛胃肠道内窥镜检查是现代医学的一项重要诊断技术,对患者的舒适度和检查质量至关重要。雷马唑仑作为一种新型镇静药物,在无痛胃肠镜检查中的应用前景广阔。本文旨在探讨雷马唑仑在无痛胃肠镜检查中的最佳用药剂量,并分析其对患者舒适度的影响。通过比较不同剂量下的镇静深度、恢复时间、不良反应发生率等指标,我们发现一定的剂量范围可以在保证检查效果的同时最大限度地提高患者的舒适度。最后,我们对这一剂量范围内的雷马唑仑进行了深入分析,探讨其提高患者舒适度的机理。结果表明,该剂量范围内的咪唑安定能有效缓解患者的焦虑和恐惧,减轻检查过程中的不适感,从而提高患者的整体满意度。
{"title":"Exploration of the Optimal Dosage of Remimazolam in Painless Gastrointestinal Endoscopy and Analysis of Its Impact on Patient Comfort","authors":"Sanjie Gao","doi":"10.32629/jcmr.v5i2.2321","DOIUrl":"https://doi.org/10.32629/jcmr.v5i2.2321","url":null,"abstract":"Painless gastrointestinal endoscopy, as an important diagnostic technique in modern medicine, is crucial for patient comfort and examination quality. Remimazolam, as a novel sedative drug, has demonstrated promising applications in painless gastrointestinal endoscopy. This article aims to explore the optimal dosage of remimazolam in painless gastrointestinal endoscopy and analyze its impact on patient comfort..By comparing indicators such as sedation depth, recovery time, and incidence of adverse reactions under different dosages, we found that a certain dosage range can maximize patient comfort while ensuring the effectiveness of the examination.Finally, we conducted a thorough analysis of remimazolam within this dosage range, exploring its mechanism of improving patient comfort. The results showed that this dosage range of remimazolam can effectively alleviate patients' anxiety and fear, reduce discomfort during the examination, and thereby improve their overall satisfaction.","PeriodicalId":15431,"journal":{"name":"Journal of Clinical Medicine Research","volume":" 25","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141675078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
One Case of Solar Dermatitis Treated with Umbilical Needle "Four Positions" Combined with Body Acupuncture 脐针 "四势 "结合体针治疗日光性皮炎一例
Pub Date : 2024-07-05 DOI: 10.32629/jcmr.v5i2.2304
Wenxia Zhao, Chaoming Chen
Solar dermatitis is a kind of hypersensitive skin disease, the main clinical manifestations are redness, swelling, itching and burning. A case of solar dermatitis treated with umbilical acupuncture "four positive positions" combined with body acupuncture by Professor Chen Chaoming is introduced, which provides a new way of thinking for the treatment of solar dermatitis by clinical Chinese medicine external therapy.
日光性皮炎是一种超敏性皮肤病,主要临床表现为红、肿、痒、灼热等。介绍了陈超明教授采用脐针 "四正位 "结合体针治疗日光性皮炎的一例病例,为临床中医外治法治疗日光性皮炎提供了新思路。
{"title":"One Case of Solar Dermatitis Treated with Umbilical Needle \"Four Positions\" Combined with Body Acupuncture","authors":"Wenxia Zhao, Chaoming Chen","doi":"10.32629/jcmr.v5i2.2304","DOIUrl":"https://doi.org/10.32629/jcmr.v5i2.2304","url":null,"abstract":"Solar dermatitis is a kind of hypersensitive skin disease, the main clinical manifestations are redness, swelling, itching and burning. A case of solar dermatitis treated with umbilical acupuncture \"four positive positions\" combined with body acupuncture by Professor Chen Chaoming is introduced, which provides a new way of thinking for the treatment of solar dermatitis by clinical Chinese medicine external therapy.","PeriodicalId":15431,"journal":{"name":"Journal of Clinical Medicine Research","volume":" 37","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141673352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Journal of Clinical Medicine Research
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1