In recent years, China has been suffering from an increasing number of patients with chronic diseases such as diabetes, hypertension, and heart disease, which are gradually showing a "younger" trend. As health problems become more prominent, choosing good cooking oil has become crucial. People are beginning to realize the significance of a balanced diet and healthy eating habits in maintaining good health. Peony seed oil is rich in nutrients, and its content of unsaturated fatty acids can reach over 85%, with the highest content of α-linolenic acid, which effectively lowers blood sugar. Suppose soybean oil and rapeseed oil are combined and added. In that case, the original efficacy of peony seed oil can be complemented and enhanced, its mechanism of action network can be sound, and its nutritional composition can be enriched. We can obtain an optimal ratio for mixing the above several oils by studying their effects and roles. This paper explored the inhibitory effects of peony seed oil, soybean oil, and rapeseed oil on α-amylase activity and α-glucosidase activity, and their optimal ratios were determined by a one-way test and response surface method. The results showed that the optimal ratio was peony seed oil: soybean oil: rapeseed oil = 60:27:13. The results provide specific technology and reference for the development and utilization of peony and provide a particular theoretical basis for the development of hypoglycemic drugs or health food.
{"title":"Study on the in Vitro Inhibitory Activity of Peony Seed Blended Oil on α-Amylase and α-Glucosidase","authors":"Tiantian Sun, Zirui Chang, Fengliang Zhong, Zishu Li, Yu Fu, Yuning Gu","doi":"10.32629/jcmr.v5i2.2288","DOIUrl":"https://doi.org/10.32629/jcmr.v5i2.2288","url":null,"abstract":"In recent years, China has been suffering from an increasing number of patients with chronic diseases such as diabetes, hypertension, and heart disease, which are gradually showing a \"younger\" trend. As health problems become more prominent, choosing good cooking oil has become crucial. People are beginning to realize the significance of a balanced diet and healthy eating habits in maintaining good health. Peony seed oil is rich in nutrients, and its content of unsaturated fatty acids can reach over 85%, with the highest content of α-linolenic acid, which effectively lowers blood sugar. Suppose soybean oil and rapeseed oil are combined and added. In that case, the original efficacy of peony seed oil can be complemented and enhanced, its mechanism of action network can be sound, and its nutritional composition can be enriched. We can obtain an optimal ratio for mixing the above several oils by studying their effects and roles. This paper explored the inhibitory effects of peony seed oil, soybean oil, and rapeseed oil on α-amylase activity and α-glucosidase activity, and their optimal ratios were determined by a one-way test and response surface method. The results showed that the optimal ratio was peony seed oil: soybean oil: rapeseed oil = 60:27:13. The results provide specific technology and reference for the development and utilization of peony and provide a particular theoretical basis for the development of hypoglycemic drugs or health food.","PeriodicalId":15431,"journal":{"name":"Journal of Clinical Medicine Research","volume":"9 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141703070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bioimpedance technology (BMI) is a non-invasive detection technology that widely applied in volume measurement, human tissue structure analysis and human body composition analysis. It uses the electrical characteristics, such as impedance, admittance and dielectric constant, and changes of biological tissues and organs to extract biomedical information about human physiological and pathological conditions. This paper analyzes the influence of the distribution of frequency points on the characteristic parameters in the measurement of bio-impedance spectrum. A new method of sampling frequency points, namely the real axis equidistant method, is proposed, and this algorithm is used in the actual test. Without changing the total number of measurement frequency points, this method can effectively improve the accuracy of feature parameter α and fc calculation by increasing the number of intermediate sampling frequency points, and improve the accuracy of human body composition estimation. At last, the impedance of human body section is measured, and the characteristic parameters of human body section bio-impedance spectrum are analyzed. The continuous bioelectrical impedance changes caused by water and sugar were observed. It was initially found that drinking water led to an increase in impedance and drinking sugar led to a decrease in impedance. It lays a theoretical foundation for further research on human body data.
{"title":"Research on Bioimpedance Technology Based on Real Axis Equidistant Method","authors":"Ruyi Jiao, Bingqi Chu, Ping Liu, Qiong Gong, Dongxiu Zhou, Shuilan Li, Huasheng Qin, Cheng Fang","doi":"10.32629/jcmr.v5i2.2115","DOIUrl":"https://doi.org/10.32629/jcmr.v5i2.2115","url":null,"abstract":"Bioimpedance technology (BMI) is a non-invasive detection technology that widely applied in volume measurement, human tissue structure analysis and human body composition analysis. It uses the electrical characteristics, such as impedance, admittance and dielectric constant, and changes of biological tissues and organs to extract biomedical information about human physiological and pathological conditions. This paper analyzes the influence of the distribution of frequency points on the characteristic parameters in the measurement of bio-impedance spectrum. A new method of sampling frequency points, namely the real axis equidistant method, is proposed, and this algorithm is used in the actual test. Without changing the total number of measurement frequency points, this method can effectively improve the accuracy of feature parameter α and fc calculation by increasing the number of intermediate sampling frequency points, and improve the accuracy of human body composition estimation. At last, the impedance of human body section is measured, and the characteristic parameters of human body section bio-impedance spectrum are analyzed. The continuous bioelectrical impedance changes caused by water and sugar were observed. It was initially found that drinking water led to an increase in impedance and drinking sugar led to a decrease in impedance. It lays a theoretical foundation for further research on human body data.","PeriodicalId":15431,"journal":{"name":"Journal of Clinical Medicine Research","volume":"22 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141709442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
This paper focuses on exploring new methods for preparing platelet-rich plasma (PRP) to improve its clinical application and popularization. As a natural growth factor, PRP has significant advantages in promoting tissue repair and alleviating inflammation, but limitations in preparation methods hinder its widespread use. The study uses clinical medical syringes as the centrifuge container for PRP preparation. Without disrupting the stratification of the blood, the method employs a pushing technique to move the density gradient centrifuged blood through a medical three-way valve, separating the different blood components to obtain the target PRP layer. This method is simple to operate, has a higher recovery efficiency, and ensures the blood is handled in a closed environment throughout the process, reducing environmental contamination. It can be performed in ordinary settings. The authors seek a feasible, easy-to-operate, environmentally low-requirement, and low-cost separation method to facilitate the clinical popularization of PRP.
{"title":"Feasibility Study on Using Syringes to Separate Human Peripheral Blood for Preparing Platelet-Rich Plasma (PRP)","authors":"Youhe Tang, Xinyuan Tang, Mengjun Wang","doi":"10.32629/jcmr.v5i2.2291","DOIUrl":"https://doi.org/10.32629/jcmr.v5i2.2291","url":null,"abstract":"This paper focuses on exploring new methods for preparing platelet-rich plasma (PRP) to improve its clinical application and popularization. As a natural growth factor, PRP has significant advantages in promoting tissue repair and alleviating inflammation, but limitations in preparation methods hinder its widespread use. The study uses clinical medical syringes as the centrifuge container for PRP preparation. Without disrupting the stratification of the blood, the method employs a pushing technique to move the density gradient centrifuged blood through a medical three-way valve, separating the different blood components to obtain the target PRP layer. This method is simple to operate, has a higher recovery efficiency, and ensures the blood is handled in a closed environment throughout the process, reducing environmental contamination. It can be performed in ordinary settings. The authors seek a feasible, easy-to-operate, environmentally low-requirement, and low-cost separation method to facilitate the clinical popularization of PRP.","PeriodicalId":15431,"journal":{"name":"Journal of Clinical Medicine Research","volume":"18 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141710299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: It's to understand and analyze the current status of nosocomial infection management in primary medical institutions. Methods: Through on-site investigation and analysis, the existing problems in nosocomial infection management in primary hospitals were identified, and countermeasures were analyzed and explored. Results: Effective management of infections in primary hospitals requires attention from hospital leadership, leveraging the role of infection management personnel, strict adherence to various systems, norms, and national standards, and ensuring the active participation of personnel to ensure smooth progress in infection management at the grassroots level. Conclusion: Primary hospitals should enhance infection control, focusing on establishing systems, providing training, standardizing operations, and implementing comprehensive monitoring. This is crucial for the survival and development of hospitals.
{"title":"Investigation on Infection Management in 156 Primary Medical Institutions","authors":"Yuguang Wang, Ruipeng Song, Yancai Jia","doi":"10.32629/jcmr.v5i2.2289","DOIUrl":"https://doi.org/10.32629/jcmr.v5i2.2289","url":null,"abstract":"Objective: It's to understand and analyze the current status of nosocomial infection management in primary medical institutions. Methods: Through on-site investigation and analysis, the existing problems in nosocomial infection management in primary hospitals were identified, and countermeasures were analyzed and explored. Results: Effective management of infections in primary hospitals requires attention from hospital leadership, leveraging the role of infection management personnel, strict adherence to various systems, norms, and national standards, and ensuring the active participation of personnel to ensure smooth progress in infection management at the grassroots level. Conclusion: Primary hospitals should enhance infection control, focusing on establishing systems, providing training, standardizing operations, and implementing comprehensive monitoring. This is crucial for the survival and development of hospitals.","PeriodicalId":15431,"journal":{"name":"Journal of Clinical Medicine Research","volume":"11 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141704420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Chhabindra Nepal, Ojbindra Kc, M. Koirala, A. Subedi, Rakshya Sharma, S. Annangi, Suha Jabak, Said Chaaban
{"title":"A Retrospective Study Comparing the Effect of Conventional Coagulation Parameters Vs. Thromboelastography-Guided Blood Product Utilization in Patients With Major Gastrointestinal Bleeding","authors":"Chhabindra Nepal, Ojbindra Kc, M. Koirala, A. Subedi, Rakshya Sharma, S. Annangi, Suha Jabak, Said Chaaban","doi":"10.14740/jocmr5022","DOIUrl":"https://doi.org/10.14740/jocmr5022","url":null,"abstract":"","PeriodicalId":15431,"journal":{"name":"Journal of Clinical Medicine Research","volume":"512 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139022083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Tanida, Ryoji Kubo, Shoichiro Yoshii, Takuya Takahama, S. Sasoh, Y. Kubota, Tesshin Ban, Tomoaki Ando, M. Nakamura, Takashi Joh
A 44-year-old woman who had been diagnosed with ulcerative colitis (UC) at 22 years old was diagnosed with severe flare-up of UC based on endoscopic findings associated with new-onset active pyoderma gangrenosum (PG) on both lower legs after she decided to discontinue UC treatment. Systemic treatment with intravenous prednisolone at 30 mg/day had achieved insufficient response to UC and PG, resulting in a diagnosis of corticosteroid-refractory UC and PG. Combination therapy with upadacitinib at 45 mg/day plus intensive granulocyte and monocyte adsorptive apheresis (GMA) was started to achieve clinical remission of UC. Ten weeks after starting this combination therapy, clinical improvement of UC was achieved with PG ulcer healing on both lower legs. A combination of upadacitinib plus intensive GMA may offer an effective therapeutic option for patients with active PG in addition to UC but has yet to be approved for induction or maintenance treatment of PG worldwide. PG is a dermatological involvement in UC patients that requires attention.
{"title":"Upadacitinib Plus Intensive Granulocyte and Monocyte Adsorptive Apheresis for Ulcerative Colitis Achieved Ulcer Healing for Pyoderma Gangrenosum","authors":"S. Tanida, Ryoji Kubo, Shoichiro Yoshii, Takuya Takahama, S. Sasoh, Y. Kubota, Tesshin Ban, Tomoaki Ando, M. Nakamura, Takashi Joh","doi":"10.14740/jocmr5005","DOIUrl":"https://doi.org/10.14740/jocmr5005","url":null,"abstract":"A 44-year-old woman who had been diagnosed with ulcerative colitis (UC) at 22 years old was diagnosed with severe flare-up of UC based on endoscopic findings associated with new-onset active pyoderma gangrenosum (PG) on both lower legs after she decided to discontinue UC treatment. Systemic treatment with intravenous prednisolone at 30 mg/day had achieved insufficient response to UC and PG, resulting in a diagnosis of corticosteroid-refractory UC and PG. Combination therapy with upadacitinib at 45 mg/day plus intensive granulocyte and monocyte adsorptive apheresis (GMA) was started to achieve clinical remission of UC. Ten weeks after starting this combination therapy, clinical improvement of UC was achieved with PG ulcer healing on both lower legs. A combination of upadacitinib plus intensive GMA may offer an effective therapeutic option for patients with active PG in addition to UC but has yet to be approved for induction or maintenance treatment of PG worldwide. PG is a dermatological involvement in UC patients that requires attention.","PeriodicalId":15431,"journal":{"name":"Journal of Clinical Medicine Research","volume":"30 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139018066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Takuma Hayashi, Naoya Kishimoto, K. Abiko, I. Konishi
{"title":"Treatment With Antitumor Agents Recommended by Cancer Genome Panel for Uterine Leiomyosarcoma","authors":"Takuma Hayashi, Naoya Kishimoto, K. Abiko, I. Konishi","doi":"10.14740/jocmr5052","DOIUrl":"https://doi.org/10.14740/jocmr5052","url":null,"abstract":"","PeriodicalId":15431,"journal":{"name":"Journal of Clinical Medicine Research","volume":"81 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139013997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Disparities in Palliative Care Among Critically Ill Patients With and Without COVID-19 at the End of Life: A Population-Based Analysis","authors":"L. Oud","doi":"10.14740/jocmr5027","DOIUrl":"https://doi.org/10.14740/jocmr5027","url":null,"abstract":"","PeriodicalId":15431,"journal":{"name":"Journal of Clinical Medicine Research","volume":"336 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139023688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: To study the prevention and treatment strategies for pressure injury in the operating room. Methods: 116 patients who underwent surgery in our hospital from January 2016 to May 2023 were selected as research subjects by random number method, and were randomly divided into the research group (n=58) and the control group (n=58). The control group was treated with conventional interventions, and the research group was treated with interventions in the operating room. The incidence of pressure injuries, pressure injury recovery scoring, SAS, and SDS scores were compared between the two groups. Results: After the intervention, the incidence of pressure injuries in the research group was lower than that in the control group, and the postoperative mobility and perception were better than those in the control group. In addition, the negative emotions such as anxiety and depression produced during the treatment of the patients in the research group were more effectively alleviated under intervention. The results of this study are statistically significant, with P < 0.05. Conclusion: Intervention measures can effectively alleviate the negative emotions produced during the treatment of patients, reduce the incidence of postoperative pressure injuries, alleviate the patient's pain and financial pressure, shorten the recovery time of patients, and improve the mobility and perception ability of patients after the occurrence of compression injuries.
{"title":"Study on Prevention and Treatment Strategies for Pressure Injury in Operating Room","authors":"M. Shan, Li Wang, Wenjing Cui, Xiaoxin Fu","doi":"10.32629/jcmr.v4i2.1247","DOIUrl":"https://doi.org/10.32629/jcmr.v4i2.1247","url":null,"abstract":"Objective: To study the prevention and treatment strategies for pressure injury in the operating room. Methods: 116 patients who underwent surgery in our hospital from January 2016 to May 2023 were selected as research subjects by random number method, and were randomly divided into the research group (n=58) and the control group (n=58). The control group was treated with conventional interventions, and the research group was treated with interventions in the operating room. The incidence of pressure injuries, pressure injury recovery scoring, SAS, and SDS scores were compared between the two groups. Results: After the intervention, the incidence of pressure injuries in the research group was lower than that in the control group, and the postoperative mobility and perception were better than those in the control group. In addition, the negative emotions such as anxiety and depression produced during the treatment of the patients in the research group were more effectively alleviated under intervention. The results of this study are statistically significant, with P < 0.05. Conclusion: Intervention measures can effectively alleviate the negative emotions produced during the treatment of patients, reduce the incidence of postoperative pressure injuries, alleviate the patient's pain and financial pressure, shorten the recovery time of patients, and improve the mobility and perception ability of patients after the occurrence of compression injuries.","PeriodicalId":15431,"journal":{"name":"Journal of Clinical Medicine Research","volume":"88 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76858447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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