Numerous studies have shown that the central nervous system plays a crucial role in regulating feeding behavior [1]. Within the central nervous system, many nuclei and neural circuitry are involved in regulating feeding behavior, such as the ventral tegmental area (VTA), lateral hypothalamus (LH), tuberomammillary nucleus (TN), and amygdala (CeA). Among these, the lateral hypothalamus is a critical target for the regulation of homeostatic feeding. Previous studies on LH regulation of feeding behavior have mostly focused on neurons and neural circuits, with relatively fewer studies on astrocytes.
{"title":"The Hypothesis and Research on the Regulation of Mouse Feeding Behavior by Astrocytes in the Lateral Hypothalamic Area","authors":"Zefu Yin, Yuzhe Jiang, Jie Chen","doi":"10.32629/jcmr.v5i2.2305","DOIUrl":"https://doi.org/10.32629/jcmr.v5i2.2305","url":null,"abstract":"Numerous studies have shown that the central nervous system plays a crucial role in regulating feeding behavior [1]. Within the central nervous system, many nuclei and neural circuitry are involved in regulating feeding behavior, such as the ventral tegmental area (VTA), lateral hypothalamus (LH), tuberomammillary nucleus (TN), and amygdala (CeA). Among these, the lateral hypothalamus is a critical target for the regulation of homeostatic feeding. Previous studies on LH regulation of feeding behavior have mostly focused on neurons and neural circuits, with relatively fewer studies on astrocytes.","PeriodicalId":15431,"journal":{"name":"Journal of Clinical Medicine Research","volume":"103 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141674219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bingqian Wang, Yuchen Zhang, Yang Liu, Wenxiang Hu, Yalei Pan, Yin'gang Li
"Liver is the master of tendon and kidney is the master of bone" is an important theoretical source for the treatment of lumbar disc herniation (LDH) in traditional Chinese medicine (TCM). Most of the patients with LDH are in liver and kidney deficiency, and the treatment of LDH is often based on traditional Chinese medicines that tonify the liver and kidneys. With the development of modern medicine, some progress has been made in recent years on the pathogenesis, diagnostic imaging and therapeutic mechanism of LDH based on the theory of "the liver is in charge of the tendons and the kidney is in charge of the bones", and this article will briefly review these aspects to provide a reference for the better utilization of this theory in the treatment of LDH.
{"title":"Research Progress in the Treatment of Lumbar Intervertebral Disc Herniation Based on the Theory of \"the Liver Is in Charge of Tendons and the Kidney Is in Charge of Bones\"","authors":"Bingqian Wang, Yuchen Zhang, Yang Liu, Wenxiang Hu, Yalei Pan, Yin'gang Li","doi":"10.32629/jcmr.v5i2.2331","DOIUrl":"https://doi.org/10.32629/jcmr.v5i2.2331","url":null,"abstract":"\"Liver is the master of tendon and kidney is the master of bone\" is an important theoretical source for the treatment of lumbar disc herniation (LDH) in traditional Chinese medicine (TCM). Most of the patients with LDH are in liver and kidney deficiency, and the treatment of LDH is often based on traditional Chinese medicines that tonify the liver and kidneys. With the development of modern medicine, some progress has been made in recent years on the pathogenesis, diagnostic imaging and therapeutic mechanism of LDH based on the theory of \"the liver is in charge of the tendons and the kidney is in charge of the bones\", and this article will briefly review these aspects to provide a reference for the better utilization of this theory in the treatment of LDH.","PeriodicalId":15431,"journal":{"name":"Journal of Clinical Medicine Research","volume":" 47","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141673412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Randomized controlled studies have shown that the incidence of postoperative cognitive function in elderly patients undergoing hip fracture surgery varies significantly by anesthesia type. The aim of this study was to assess the effects of intrathecal anesthesia and general anesthesia on postoperative cognitive function in elderly hip fracture by system review and meta-analysis. This study followed the guidance of the Preferred Reporting Items for Systematic Reviews and Meta-analyses. First, the Cochrane Library, Web of Science, PubMed, EMBASE, Chinese Biomedical Literature Database, China National Knowledge Infrastructure, China Science and Technology Journal Database, Wanfang Database, and Clinical Trials Database were searched. Second, the literature was screened and identified for inclusion step by step according to the established inclusion and exclusion criteria using Endnote. Further, Excel 2010 was used to record the basic characteristics and relevant data of the included literature, and the Cochrane Risk of Bias Assessment Tool was used to rate the quality of each included study. Subsequently, meta-analysis was performed using RevMan 5.3 software to assess the effects of intrathecal anesthesia and general anesthesia on postoperative cognitive function of hip fracture in the elderly, and funnel plots were drawn to assess publication bias. The results of this systematic evaluation and meta-analysis will be published in a peer-reviewed journal.
{"title":"Effects of Intrathecal Versus General Anesthesia on Postoperative Cognitive Function in Elderly Hip Fracture Patients: a System Review and Meta Analysis Protocol","authors":"Juan Deng, Junli Li, Yangfan Cai","doi":"10.32629/jcmr.v5i2.2322","DOIUrl":"https://doi.org/10.32629/jcmr.v5i2.2322","url":null,"abstract":"Randomized controlled studies have shown that the incidence of postoperative cognitive function in elderly patients undergoing hip fracture surgery varies significantly by anesthesia type. The aim of this study was to assess the effects of intrathecal anesthesia and general anesthesia on postoperative cognitive function in elderly hip fracture by system review and meta-analysis. This study followed the guidance of the Preferred Reporting Items for Systematic Reviews and Meta-analyses. First, the Cochrane Library, Web of Science, PubMed, EMBASE, Chinese Biomedical Literature Database, China National Knowledge Infrastructure, China Science and Technology Journal Database, Wanfang Database, and Clinical Trials Database were searched. Second, the literature was screened and identified for inclusion step by step according to the established inclusion and exclusion criteria using Endnote. Further, Excel 2010 was used to record the basic characteristics and relevant data of the included literature, and the Cochrane Risk of Bias Assessment Tool was used to rate the quality of each included study. Subsequently, meta-analysis was performed using RevMan 5.3 software to assess the effects of intrathecal anesthesia and general anesthesia on postoperative cognitive function of hip fracture in the elderly, and funnel plots were drawn to assess publication bias. The results of this systematic evaluation and meta-analysis will be published in a peer-reviewed journal.","PeriodicalId":15431,"journal":{"name":"Journal of Clinical Medicine Research","volume":" 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141674594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: To explore the clinical effect and cardiac function of moxibustion licorice decoction combined with metoprolol in the treatment of coronary heart disease arrhythmia. Method: 92 patients with coronary heart disease and arrhythmia admitted from January 2022 to December 2023 were selected as the analysis subjects. Divide into a control group and an observation group using envelope randomization method. The former is treated with metoprolol, while the latter is treated with moxibustion licorice soup and metoprolol. Compare clinical efficacy, cardiac function, heart rate variability, and adverse reactions. The total effective rate of the observation group treatment was 95.65%, which was higher than that of the control group 82.61% (X2=4.039, P=0.044); The LVESD and CO levels in the observation group were lower than those in the control group, while the LVEF and LVEDD levels were higher than those in the control group (P<0.05); The number of atrial premature beats and ventricular premature beats at 24 hours in the observation group was lower than that in the control group, and the levels of SDNN and SDANN were higher than those in the control group (P<0.05); The incidence of adverse reactions in the observation group was 6.52%, which was lower than that in the control group (X2=4.389, P=0.036). Conclusion: For patients with coronary heart disease and arrhythmia, moxibustion with licorice decoction combined with metoprolol has a clear effect, can improve heart function, reduce myocardial contractility, and is relatively safe.
{"title":"Clinical Efficacy and Cardiac Function Analysis of Zhigancao Decoction Combined With Metoprolol in the Treatment of Coronary Heart Disease Arrhythmias","authors":"Ting Wang","doi":"10.32629/jcmr.v5i2.2328","DOIUrl":"https://doi.org/10.32629/jcmr.v5i2.2328","url":null,"abstract":"Objective: To explore the clinical effect and cardiac function of moxibustion licorice decoction combined with metoprolol in the treatment of coronary heart disease arrhythmia. Method: 92 patients with coronary heart disease and arrhythmia admitted from January 2022 to December 2023 were selected as the analysis subjects. Divide into a control group and an observation group using envelope randomization method. The former is treated with metoprolol, while the latter is treated with moxibustion licorice soup and metoprolol. Compare clinical efficacy, cardiac function, heart rate variability, and adverse reactions. The total effective rate of the observation group treatment was 95.65%, which was higher than that of the control group 82.61% (X2=4.039, P=0.044); The LVESD and CO levels in the observation group were lower than those in the control group, while the LVEF and LVEDD levels were higher than those in the control group (P<0.05); The number of atrial premature beats and ventricular premature beats at 24 hours in the observation group was lower than that in the control group, and the levels of SDNN and SDANN were higher than those in the control group (P<0.05); The incidence of adverse reactions in the observation group was 6.52%, which was lower than that in the control group (X2=4.389, P=0.036). Conclusion: For patients with coronary heart disease and arrhythmia, moxibustion with licorice decoction combined with metoprolol has a clear effect, can improve heart function, reduce myocardial contractility, and is relatively safe.","PeriodicalId":15431,"journal":{"name":"Journal of Clinical Medicine Research","volume":" 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141676858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Xiaobin Li, Xiang Zhou, Xinghua Du, Rui Mei, Yuna Zhang, Dan Li, Qian Yang
Objective: To explore the clinical characteristics of insomnia patients and the function and mechanism of acupuncture therapy, to improve the recognition and diagnosis of insomnia. Methods: The clinical data of 60 patients with insomnia who met the criteria and were admitted to the Department of Acupuncture and moxibustion in Yunnan Provincial Hospital of Integrated Traditional Chinese and Western Medicine from January 2023 to February 2024 were selected, the clinical characteristics of the patients were analyzed, and the patients were randomly divided into two groups for routine treatment and acupuncture treatment, respectively, to explore the therapeutic effect and possible mechanism. Results: The insomnia symptoms of the patients were mainly difficulty in falling asleep. Acupuncture treatment could significantly improve the insomnia symptoms and promote the expression levels of DA and NE. Conclusion: Patients with insomnia have various clinical features, mainly sleep difficulties. Acupuncture treatment can significantly relieve insomnia symptoms by up-regulating DA and NE levels, and then improve sleep quality.
{"title":"Analysis of Clinical Characteristics of Insomnia Patients and Effect of Acupuncture Therapy","authors":"Xiaobin Li, Xiang Zhou, Xinghua Du, Rui Mei, Yuna Zhang, Dan Li, Qian Yang","doi":"10.32629/jcmr.v5i2.2315","DOIUrl":"https://doi.org/10.32629/jcmr.v5i2.2315","url":null,"abstract":"Objective: To explore the clinical characteristics of insomnia patients and the function and mechanism of acupuncture therapy, to improve the recognition and diagnosis of insomnia. Methods: The clinical data of 60 patients with insomnia who met the criteria and were admitted to the Department of Acupuncture and moxibustion in Yunnan Provincial Hospital of Integrated Traditional Chinese and Western Medicine from January 2023 to February 2024 were selected, the clinical characteristics of the patients were analyzed, and the patients were randomly divided into two groups for routine treatment and acupuncture treatment, respectively, to explore the therapeutic effect and possible mechanism. Results: The insomnia symptoms of the patients were mainly difficulty in falling asleep. Acupuncture treatment could significantly improve the insomnia symptoms and promote the expression levels of DA and NE. Conclusion: Patients with insomnia have various clinical features, mainly sleep difficulties. Acupuncture treatment can significantly relieve insomnia symptoms by up-regulating DA and NE levels, and then improve sleep quality.","PeriodicalId":15431,"journal":{"name":"Journal of Clinical Medicine Research","volume":" 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141674361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Non-alcoholic fatty liver disease (NAFLD) belongs to the categories of "flank pain" and "liver fetish" in traditional Chinese medicine. The causes of NAFLD are complex, such as obesity, type 2 diabetes, hyperlipidemia, hypothyroidism, hypopituitarism, sleep apnea syndrome, polycystic ovary syndrome, sexual dysfunction, acanthosis nigricans, vitamin D deficiency and osteoporosis. The causes of NAFLD are very complex, such as obesity, type 2 diabetes. With the development of Chinese society and the further improvement of people's living standards in recent years, people's daily life, working style and diet structure have also changed. The incidence of NAFLD is increasing rapidly, and it has become a common disease in the world, posing a serious threat to our health and affecting our daily life. Traditional Chinese medicine emphasizes a holistic approach and treatment based on syndrome differentiation, with multiple channels, multiple aspects, multiple levels, multiple perspectives, and minimal side effects. It has a considerable therapeutic effect in the treatment of NAFLD. This article aims to organize and summarize the research literature on Chaihu Shugan San in the treatment of NAFLD in recent years, providing reference for further clinical research and application of Chaihu Shugan San in the treatment of NAFLD.
非酒精性脂肪肝（NAFLD）属中医 "胁痛"、"肝癖 "范畴。非酒精性脂肪肝的病因非常复杂，如肥胖、2 型糖尿病、高脂血症、甲状腺功能减退、垂体功能减退、睡眠呼吸暂停综合征、多囊卵巢综合征、性功能障碍、黑棘皮症、维生素 D 缺乏、骨质疏松等。非酒精性脂肪肝的病因非常复杂，如肥胖、2 型糖尿病等。近年来，随着中国社会的发展和人民生活水平的进一步提高，人们的日常生活、工作方式和饮食结构也发生了变化。非酒精性脂肪肝的发病率迅速上升，已成为世界性的常见病，严重威胁着我们的健康，影响着我们的日常生活。中医强调整体观念和辨证论治，多渠道、多方面、多层次、多角度、少副作用。在治疗非酒精性脂肪肝方面具有相当的疗效。本文旨在对近年来柴胡疏肝散治疗非酒精性脂肪肝的研究文献进行整理和总结，为进一步开展柴胡疏肝散治疗非酒精性脂肪肝的临床研究和应用提供参考。
{"title":"Research Progress of Chaihu Shugan San in the Treatment of Non-alcoholic Fatty Liver Disease","authors":"Xiaoyu Gou, Feng Huang","doi":"10.32629/jcmr.v5i2.2313","DOIUrl":"https://doi.org/10.32629/jcmr.v5i2.2313","url":null,"abstract":"Non-alcoholic fatty liver disease (NAFLD) belongs to the categories of \"flank pain\" and \"liver fetish\" in traditional Chinese medicine. The causes of NAFLD are complex, such as obesity, type 2 diabetes, hyperlipidemia, hypothyroidism, hypopituitarism, sleep apnea syndrome, polycystic ovary syndrome, sexual dysfunction, acanthosis nigricans, vitamin D deficiency and osteoporosis. The causes of NAFLD are very complex, such as obesity, type 2 diabetes. With the development of Chinese society and the further improvement of people's living standards in recent years, people's daily life, working style and diet structure have also changed. The incidence of NAFLD is increasing rapidly, and it has become a common disease in the world, posing a serious threat to our health and affecting our daily life. Traditional Chinese medicine emphasizes a holistic approach and treatment based on syndrome differentiation, with multiple channels, multiple aspects, multiple levels, multiple perspectives, and minimal side effects. It has a considerable therapeutic effect in the treatment of NAFLD. This article aims to organize and summarize the research literature on Chaihu Shugan San in the treatment of NAFLD in recent years, providing reference for further clinical research and application of Chaihu Shugan San in the treatment of NAFLD.","PeriodicalId":15431,"journal":{"name":"Journal of Clinical Medicine Research","volume":"108 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141674215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The objective is to analyze the impact of aerobic exercise on the activation of hippocampal glial cells and the expression of inflammatory factors in the aging process of rats. Methods: Thirty male SPF (Specific Pathogen Free) rats at 10 weeks of age were selected and divided into three groups: the sedentary group (A), the aging group (B), and the aging exercise group (C), with 10 rats in each group. The sedentary group (A) was raised for 6 weeks without exercise or aging intervention; the aging group (B) was continuously injected with D-galactose for 6 weeks without exercise intervention; the aging exercise group (C) was continuously injected with D-galactose for 6 weeks while simultaneously implementing exercise intervention, with 60 minutes of unassisted swimming per day, three times a week (swimming pool size 0.5m x 0.8m, water temperature 35±2°C). All groups were harvested at the end of 6 weeks. Compared with the sedentary group, the GFAP immunohistochemical staining in the hippocampal area of the brain was stronger in both the aging group and the aging exercise group, with more GFAP expression, darker positive reaction color, and higher average fluorescence intensity than the sedentary group; compared with the aging group, the aging exercise group had less GFAP expression, lighter positive reaction color, and lower average fluorescence intensity. All differences were significant (P<0.05). In the comparison of GSH levels in the hippocampal tissue of rats, the aging group had the lowest levels, indicating a decrease in the activation level of glial cells in the hippocampus, while the aging exercise group had higher GSH levels than the aging group, proving that exercise intervention in the aging process can effectively improve the activation level of hippocampal glial cells in rats.
{"title":"The Influence of Aerobic Exercise on Hippocampal Glial Cells and Inflammatory Factor Expression in the Aging Process of Rats","authors":"Yan Song, Caini Pei","doi":"10.32629/jcmr.v5i2.2323","DOIUrl":"https://doi.org/10.32629/jcmr.v5i2.2323","url":null,"abstract":"The objective is to analyze the impact of aerobic exercise on the activation of hippocampal glial cells and the expression of inflammatory factors in the aging process of rats. Methods: Thirty male SPF (Specific Pathogen Free) rats at 10 weeks of age were selected and divided into three groups: the sedentary group (A), the aging group (B), and the aging exercise group (C), with 10 rats in each group. The sedentary group (A) was raised for 6 weeks without exercise or aging intervention; the aging group (B) was continuously injected with D-galactose for 6 weeks without exercise intervention; the aging exercise group (C) was continuously injected with D-galactose for 6 weeks while simultaneously implementing exercise intervention, with 60 minutes of unassisted swimming per day, three times a week (swimming pool size 0.5m x 0.8m, water temperature 35±2°C). All groups were harvested at the end of 6 weeks. Compared with the sedentary group, the GFAP immunohistochemical staining in the hippocampal area of the brain was stronger in both the aging group and the aging exercise group, with more GFAP expression, darker positive reaction color, and higher average fluorescence intensity than the sedentary group; compared with the aging group, the aging exercise group had less GFAP expression, lighter positive reaction color, and lower average fluorescence intensity. All differences were significant (P<0.05). In the comparison of GSH levels in the hippocampal tissue of rats, the aging group had the lowest levels, indicating a decrease in the activation level of glial cells in the hippocampus, while the aging exercise group had higher GSH levels than the aging group, proving that exercise intervention in the aging process can effectively improve the activation level of hippocampal glial cells in rats.","PeriodicalId":15431,"journal":{"name":"Journal of Clinical Medicine Research","volume":" 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141674326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
This study aims to investigate the causes of poor healing of uterine incision after caesarean section and the prevention and treatment strategies. By retrospectively analysing the clinical data of 800 patients who underwent new cesarean section between January 2021 and January 2023 in our hospital, it provides reference for improving the quality of healing. Methods: The clinical data of 800 patients with poor healing of uterine incision after cesarean section were retrospectively analysed, and the relevant influencing factors and prevention methods were summarised. Results：Factors affecting the healing of uterine incision after new type of cesarean section included age, body mass index, pregnancy and delivery, operation time, intraoperative bleeding, postoperative infection and nutritional status. Treatment included strengthening postoperative nutrition, preventing infection, and regular dressing changes. Most of the patients achieved good healing and no abnormality was seen at 2-month follow-up. Conclusion: Poor healing of uterine incision after new-style cesarean section is related to many factors, but the incidence can be reduced by preoperative preparation and postoperative care. For the poor healing that has occurred, timely and correct treatment measures can help promote incision healing and reduce complications. Attention should be paid to related factors and preventive and therapeutic measures should be taken to improve the quality of healing. It is also crucial to strengthen the training of healthcare professionals and rehabilitation exercises for patients.
{"title":"Causes of Poor Incision Healing after Caesarean Section and Strategies to Prevent it","authors":"Lingyan Zhang, Kai'e Zhe","doi":"10.32629/jcmr.v5i2.2309","DOIUrl":"https://doi.org/10.32629/jcmr.v5i2.2309","url":null,"abstract":"This study aims to investigate the causes of poor healing of uterine incision after caesarean section and the prevention and treatment strategies. By retrospectively analysing the clinical data of 800 patients who underwent new cesarean section between January 2021 and January 2023 in our hospital, it provides reference for improving the quality of healing. Methods: The clinical data of 800 patients with poor healing of uterine incision after cesarean section were retrospectively analysed, and the relevant influencing factors and prevention methods were summarised. Results：Factors affecting the healing of uterine incision after new type of cesarean section included age, body mass index, pregnancy and delivery, operation time, intraoperative bleeding, postoperative infection and nutritional status. Treatment included strengthening postoperative nutrition, preventing infection, and regular dressing changes. Most of the patients achieved good healing and no abnormality was seen at 2-month follow-up. Conclusion: Poor healing of uterine incision after new-style cesarean section is related to many factors, but the incidence can be reduced by preoperative preparation and postoperative care. For the poor healing that has occurred, timely and correct treatment measures can help promote incision healing and reduce complications. Attention should be paid to related factors and preventive and therapeutic measures should be taken to improve the quality of healing. It is also crucial to strengthen the training of healthcare professionals and rehabilitation exercises for patients.","PeriodicalId":15431,"journal":{"name":"Journal of Clinical Medicine Research","volume":" 22","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141675887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
This review aims to explore the emerging role of the tumor microbiome in tumor development and treatment, particularly in the impact of chemotherapy responses in patients with colorectal cancer. We discussed that the gut microbiome may influence the occurrence and progression of colorectal cancer by participating in the occurrence of colorectal cancer and regulating the host's immune response and metabolic status, as well as the effect of chemotherapy by influencing drug metabolism, regulating immune response, or participating in the side effects of chemotherapy. Research suggests that tweaking the gut microbiome may help improve the efficacy of chemotherapy. This may involve strategies such as the use of probiotics, prebiotics, or fecal microbial transplants. However, there are many challenges to the application of these strategies, such as the fact that we do not yet know which microbes are beneficial and which are harmful, and that the same strategy may have different effects on different people. Future research may therefore focus on a deeper understanding of how the gut microbiome influences tumor biological behavior and how this knowledge can be used to improve treatment outcomes for patients with colorectal cancer.
{"title":"Effect of Gut Microbiome on Chemotherapy Response in Patients with Colorectal Cancer: a Prospective Cohort Study","authors":"Xuying Ma, Ying Wang, Shuang Zheng","doi":"10.32629/jcmr.v5i2.2320","DOIUrl":"https://doi.org/10.32629/jcmr.v5i2.2320","url":null,"abstract":"This review aims to explore the emerging role of the tumor microbiome in tumor development and treatment, particularly in the impact of chemotherapy responses in patients with colorectal cancer. We discussed that the gut microbiome may influence the occurrence and progression of colorectal cancer by participating in the occurrence of colorectal cancer and regulating the host's immune response and metabolic status, as well as the effect of chemotherapy by influencing drug metabolism, regulating immune response, or participating in the side effects of chemotherapy. Research suggests that tweaking the gut microbiome may help improve the efficacy of chemotherapy. This may involve strategies such as the use of probiotics, prebiotics, or fecal microbial transplants. However, there are many challenges to the application of these strategies, such as the fact that we do not yet know which microbes are beneficial and which are harmful, and that the same strategy may have different effects on different people. Future research may therefore focus on a deeper understanding of how the gut microbiome influences tumor biological behavior and how this knowledge can be used to improve treatment outcomes for patients with colorectal cancer.","PeriodicalId":15431,"journal":{"name":"Journal of Clinical Medicine Research","volume":" 33","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141675645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: It’s to analyze the clinical treatment efficacy and incidence of complications in asymmetric double eyelid repair surgery. Methods: Fifty patients who underwent asymmetric double eyelid repair surgery at our hospital from March 2022 to March 2023 were selected. Using a random number table, the patients were divided into two groups of equal size. The observation group (n=25) underwent small incision fat removal and continuous buried suture repair, while the control group (n=25) underwent traditional incision surgery. The treatment efficacy (excellent, effective, ineffective) and one-year postoperative complication incidence (conjunctival blockage, eye swelling, bruising) were compared between the two groups, as well as clinical data (operation time, healing time, incision length). Results: The total effective rate in the observation group (96%) was higher than that in the control group (64%); the one-year postoperative complication incidence in the observation group was lower than that in the control group (P<0.05); the operation time, healing time, and incision length in the observation group were all less than those in the control group (P<0.05). Conclusion: Double eyelid repair surgery demonstrates significant clinical efficacy and a low incidence of complications in treating asymmetric double eyelids, warranting further promotion.
{"title":"Clinical Treatment Efficacy and Incidence of Complications in Asymmetric Double Eyelid Repair Surgery","authors":"Feng Jiao","doi":"10.32629/jcmr.v5i2.2290","DOIUrl":"https://doi.org/10.32629/jcmr.v5i2.2290","url":null,"abstract":"Objective: It’s to analyze the clinical treatment efficacy and incidence of complications in asymmetric double eyelid repair surgery. Methods: Fifty patients who underwent asymmetric double eyelid repair surgery at our hospital from March 2022 to March 2023 were selected. Using a random number table, the patients were divided into two groups of equal size. The observation group (n=25) underwent small incision fat removal and continuous buried suture repair, while the control group (n=25) underwent traditional incision surgery. The treatment efficacy (excellent, effective, ineffective) and one-year postoperative complication incidence (conjunctival blockage, eye swelling, bruising) were compared between the two groups, as well as clinical data (operation time, healing time, incision length). Results: The total effective rate in the observation group (96%) was higher than that in the control group (64%); the one-year postoperative complication incidence in the observation group was lower than that in the control group (P<0.05); the operation time, healing time, and incision length in the observation group were all less than those in the control group (P<0.05). Conclusion: Double eyelid repair surgery demonstrates significant clinical efficacy and a low incidence of complications in treating asymmetric double eyelids, warranting further promotion.","PeriodicalId":15431,"journal":{"name":"Journal of Clinical Medicine Research","volume":"49 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141688542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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