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Skin Permeation of Hazardous Compounds of Tobacco Smoke in Presence of Antipollution Cosmetics. 抗污染化妆品对烟草烟雾中有害化合物的皮肤渗透作用。
IF 0.2 4区 医学 Q4 CHEMISTRY, APPLIED Pub Date : 2021-07-01
Soraya Pontes-López, Ana Gonzálvez, Francesc A Esteve-Turrillas, Sergio Armenta

Negative health effects of active and passive smokers have been widely described, but the effect of tobacco smoke on the skin has been less explored. In this study, an analytical methodology has been developed to evaluate the dermal permeation of hazardous compounds present in tobacco smoke, using an exposition chamber to simulate finite and infinite smoking conditions, in vitro vertical Franz diffusion cells, and Strat-M® membranes as human skin simulants. Moreover, the antipollution effect of three cosmetics has been evaluated, showing a significant efficacy to reduce dermal permeation of hazardous tobacco-smoke compounds such as of nicotine and aromatic hydrocarbons.

主动吸烟者和被动吸烟者对健康的负面影响已被广泛描述,但烟草烟雾对皮肤的影响却鲜有探讨。在这项研究中,我们开发了一种分析方法来评估烟草烟雾中有害化合物的皮肤渗透性,该方法使用了模拟有限和无限吸烟条件的暴露室、体外垂直弗兰兹扩散细胞以及作为人体皮肤模拟物的 Strat-M® 膜。此外,还对三种化妆品的抗污染效果进行了评估,结果表明它们在减少尼古丁和芳香烃等有害烟草烟雾化合物的皮肤渗透方面具有显著功效。
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引用次数: 0
Rheology of Cosmetic Products: Surfactant Mesophases, Foams and Emulsions. 化妆品流变学:表面活性剂中间相、泡沫和乳液。
IF 0.4 4区 医学 Q4 CHEMISTRY, APPLIED Pub Date : 2020-11-01
Aina Davies, Samiul Amin

Cosmetic products such as shampoos, body washes, mascaras, and foundations can all be classified essentially as complex fluids. Depending on the product format, the specific complex fluid used in a formulation can range from self-assembled surfactant systems found in most cleansing products to oil-in-water and water-in-oil emulsions found in makeup, color cosmetics, and skin care. These complex fluids play a critical role in giving rise to rheological and tribological properties necessary for both sensory and functional performance. Critical functional properties such as product stability and wet hair conditioning are impacted significantly through any changes in the product rheology. Positive sensorial properties of products are always desired by consumers, and as such, it is critical to always consider how to optimize formulation rheology to adequately deliver desirable sensory performance and properties. This review will focus on the importance of understanding and characterizing the rheology of complex fluids used in cosmetic products. A review and analysis of the recent literature in this area is presented.

洗发水、沐浴露、睫毛膏和粉底等化妆品基本上都可以归类为复杂的液体。根据产品形式的不同,配方中使用的特定复合流体可以从大多数清洁产品中使用的自组装表面活性剂系统到化妆品、彩妆和护肤品中使用的水包油和水包油乳液。这些复杂的流体在产生流变学和摩擦学特性方面起着至关重要的作用,而流变学和摩擦学特性是感官和功能性能所必需的。关键的功能特性,如产品的稳定性和湿发调理显著影响通过产品流变学的任何变化。消费者总是希望产品具有积极的感官特性,因此,始终考虑如何优化配方流变学以充分提供理想的感官性能和特性是至关重要的。这篇综述将集中在理解和表征化妆品中使用的复杂流体流变学的重要性。本文对这一领域的最新文献进行了回顾和分析。
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引用次数: 0
Application of Biosurfactants and Biopolymers in Sustainable Cosmetic Formulation Design. 生物表面活性剂和生物聚合物在可持续化妆品配方设计中的应用。
IF 0.4 4区 医学 Q4 CHEMISTRY, APPLIED Pub Date : 2020-11-01
Adeline M Benhur, Samyukta Pingali, Samiul Amin

Increased public awareness regarding the ingredients that make up cosmetic and personal care formulations coupled with the growing concern about the dwindling nonrenewable sources from which most cosmetic ingredients like surfactants and polymers are obtained from has led to a strong need to achieve sustainability within the cosmetic industry. It has become the need of the hour to incorporate sustainability at each and every point of the product life cycle. This review focuses on the sustainable sourcing and formulation design of two key cosmetic ingredients-polymers and surfactants. To be able to completely replace their synthetic counterparts, it is crucial that these green products exhibit an efficacy level at par or greater than that of the products already on the market. Hence, various studies that show the impact of these alternatives on various performance parameters such as film formation and rheology have also been discussed. Being a heavily consumer-driven industry, some of the decisive future trends and challenges that the cosmetic industry needs to address have also been explored in this review.

公众对构成化妆品和个人护理配方的成分的认识日益提高,加上对大多数化妆品成分(如表面活性剂和聚合物)的不可再生资源日益减少的担忧,导致了化妆品行业实现可持续性的强烈需求。将可持续性纳入产品生命周期的每一个环节已成为当前的需要。本文综述了两种主要化妆品成分——聚合物和表面活性剂的可持续来源和配方设计。为了能够完全取代它们的合成对应物,这些绿色产品的功效水平与市场上已有的产品相当或更高,这一点至关重要。因此,各种研究表明,这些替代品对各种性能参数的影响,如成膜和流变性也被讨论。作为一个高度由消费者驱动的行业,化妆品行业需要解决的一些决定性的未来趋势和挑战也在本综述中进行了探讨。
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引用次数: 0
Objective Methods for Quantifying Color Retention and Bleeding Potential of a Lipstick Through Large-Scale Panel Perception and Controlled Usability Studies. 目的通过大规模的面板感知和控制可用性研究来定量口红的颜色保留和出血电位。
IF 0.4 4区 医学 Q4 CHEMISTRY, APPLIED Pub Date : 2020-11-01
Di Qu, Alyssa Johncock, Jianwei Liu

Color retention and bleeding are two properties of lipstick performance which impact consumer acceptability and preference. Before now, the claims of long-wear and non-bleeding had yet to be meaningfully substantiated quantitatively. Lack of objectively defined parameters and measurement methods inhibits one's ability of obtaining adequate claims support. In this study, we designed a 30-member, controlled-usability study to develop methods that quantify color retention and bleeding potential. Image analysis methods were used to measure lip color properties at the time points of baseline, immediate after application, and 8 hours of wear. Large-scale panel perception studies were conducted to obtain consumer acceptability criteria and establish consumer relevance of the objectively measured parameters. Our results show that the methods developed can quantitatively describe the color properties. Eight hours after application, the mean levels of color retention and bleeding potential for this specific lip color were 82.67% and 2.43, respectively. The results of panel perception studies helped establish threshold values for lip color performance acceptability, that is, if a color retention level was lower than 82.7%, or a bleeding potential level was higher than 2.37, the performance would not be deemed acceptable. The methods and results reported here serve as a useful tool for the evaluation of lip color performance in future development of quality lip color formulations.

颜色保持和出血是影响消费者接受度和偏好的口红性能的两个特性。在此之前,长期磨损和不出血的说法尚未得到有意义的定量证实。缺乏客观定义的参数和测量方法抑制了一个人获得足够的索赔支持的能力。在这项研究中,我们设计了一个30人的可控可用性研究,以开发量化颜色保留和出血潜力的方法。使用图像分析方法测量基线时间点、涂后立即时间点和涂后8小时唇色特性。进行了大规模的面板感知研究,以获得消费者可接受的标准,并建立客观测量参数的消费者相关性。结果表明,所建立的方法可以定量地描述颜色性质。使用后8小时,该特定唇色的平均保色率和出血潜势分别为82.67%和2.43%。小组感知研究的结果有助于建立唇色表现可接受性的阈值,也就是说,如果颜色保留水平低于82.7%,或者出血潜力水平高于2.37,则表现将不被认为是可接受的。本文所报道的方法和结果为今后开发高质量唇色配方时评价唇色性能提供了有用的工具。
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引用次数: 0
Determination of Required HLB Values for Citrus unshiu Fruit Oil, Citrus unshiu Peel Oil, Horse Fat and Camellia japonica Seed Oil. 柑桔果油、柑桔果皮油、马脂和山茶籽油所需HLB值的测定。
IF 0.4 4区 医学 Q4 CHEMISTRY, APPLIED Pub Date : 2020-11-01
Yu-Yeon Lee, Kyung-Sup Yoon

In the present study, the required hydrophilic lipophilic balance (HLB) values of Citrus unshiu fruit oil (CUFO), Citrus unshiu peel oil (CUPO), horse fat (HF), and Camellia japonica seed oil were determined empirically by preparing oil-in-water (o/w) emulsions. Lipophilic and hydrophilic surfactants were prepared in various ratios in o/w emulsion. The droplet size of the emulsion was measured using a particle size analyzer, and the turbidity was measured using a turbidity meter and a ultraviolet (UV)-vis spectrophotometer. According to the Orafidiya-Oladimeji method, the HLB value of the emulsion having the minimum dispersion ratio, the minimum droplet size, and the maximum turbidity degree was determined as the required HLB value for each essential oil. Based on these methods, the required HLB values of CUFO, CUPO, HF, and Camellia japonica seed oil were determined as 14.75-14.90, 15.35-15.40, 6.30-7.06, and 5.94-6.30, respectively.

本研究通过制备水包油(o/w)乳剂,经验性地测定了柑桔油(CUFO)、柑桔皮油(CUPO)、马脂(HF)和山茶籽油所需亲水亲脂平衡(HLB)值。在0 /w乳液中制备了不同比例的亲脂性和亲水性表面活性剂。用粒径分析仪测定乳化液的粒径,用浊度仪和紫外-可见分光光度计测定浊度。根据Orafidiya-Oladimeji法,确定具有最小分散比、最小液滴大小和最大浊度的乳液的HLB值作为每种精油所需的HLB值。根据上述方法确定CUFO、CUPO、HF和山茶籽油所需HLB值分别为14.75 ~ 14.90、15.35 ~ 15.40、6.30 ~ 7.06和5.94 ~ 6.30。
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引用次数: 0
Efficacy and Safety of Centella Asiatica (L.) Urb. on Wrinkles: A Systematic Review of Published Data and Network Meta-Analysis. 积雪草的有效性和安全性市区。关于皱纹:对已发表数据和网络元分析的系统回顾。
IF 0.4 4区 医学 Q4 CHEMISTRY, APPLIED Pub Date : 2020-11-01
Chuenjid Kongkaew, Peerapong Meesomperm, C Norman Scholfield, Narttaya Chaiwiang, Neti Waranuch

Centella asiatica has many applications in cosmetics, including wrinkle treatments, but its effectiveness remains to be clarified. This systematic review study aimed to demonstrate the efficacy and safety of C. asiatica for reducing facial wrinkles. PubMed, Excerpta Medica dataBASE (EMBASE), Cochrane Central Register of clinical trials, Allied and Complementary Medicine Database, Cumulative Index to Nursing and Allied Health Literature (CINAHL), Thai Library Integrated System, and Thai university database/journals were searched until May 2019. Five double-blinded randomised controlled trials, including 172 Asian females, were included. Endpoints were wrinkling measured by visual score, image analysis, and participant satisfaction. Two placebo-controlled studies applied gel/creams containing C. asiatica or asiaticoside for 12 w to periorbital skin. Two studies applied tretinoin or Pueraria mirifica contralaterally and by network meta-analysis C. asiatica appeared more effective than P. mirifica but possibly less than tretinoin. Asiaticoside applied as a lipstick for 8 w reduced lip wrinkling. Skin hydration was markedly raised by C. asiatica but not tretinoin. One study reported 10 adverse events for C. asiatica and 35 for tretinoin. Cochrane risk of bias was generally low, reporting was weak, and lack of C. asiatica standardization prevents general application. From the reported data, it is possible to conclude that C. asiatica improved lip and periocular wrinkles, and may replace retinoids if its long-term safety is established and C. asiatica is standardized.

积雪草在化妆品中有许多应用,包括皱纹治疗,但其有效性仍有待澄清。本系统综述研究旨在证明积雪草对减少面部皱纹的有效性和安全性。检索PubMed、摘录医学数据库(EMBASE)、Cochrane临床试验中央注册库、联合和补充医学数据库、护理和联合健康文献累积索引(CINAHL)、泰国图书馆集成系统和泰国大学数据库/期刊,直至2019年5月。纳入了5项双盲随机对照试验,包括172名亚洲女性。终点是通过视觉评分、图像分析和参与者满意度来测量皱纹。两项安慰剂对照研究将含有积雪草或积雪草苷的凝胶/面霜应用于眼眶周围皮肤12周。通过网络荟萃分析,两项研究分别应用维a酸或葛根对侧,亚洲葛根似乎比葛根更有效,但可能不如维a酸。用积雪草甙涂口红可减少唇纹。皮肤水合作用明显提高,但对维甲酸无明显作用。一项研究报告了10个不良事件和35个不良事件。Cochrane偏倚风险一般较低,报道较弱,缺乏亚洲金曲的标准化,阻碍了其普遍应用。从报道的数据来看,我们可以得出结论,积血草可以改善唇部和眼周皱纹,如果积血草的长期安全性得到证实,积血草被标准化,积血草可能取代类维生素a。
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引用次数: 0
A Topical Depigmentation Program Against Hyperpigmentation Enhances the Benefits of Previously Performed Chemical Peeling Procedures of the Face. 针对色素沉着的局部脱皮程序增强了先前进行的面部化学脱皮程序的益处。
IF 0.4 4区 医学 Q4 CHEMISTRY, APPLIED Pub Date : 2020-11-01
Maurizio Cavallini, Fabio Montanaro, Marco Papagni

Chemical peeling can reduce skin hyperpigmentation; however, once exhausted its thinning action, the depigmentation process does not continue further. We carried out a monocentric, prospective, noncontrolled study aimed at the evaluation of the efficacy, safety, ease of use, pleasantness, and tolerability of a depigmentation topical treatment program in women submitted to a previous chemical peeling. The topical treatment has been administered daily for 30 days to 16 women submitted to a chemical peeling containing a fixed-dose combination of salicylic acid, pyruvic acid, and retinoic acid within 7 days before study inclusion. Target skin areas have been evaluated for melanin concentration and skin texture before peeling and at study visits 1 (after peeling) and 2 (after the 30-day treatment). The topical treatment program induced a decrease in melanin concentration between study visits 1 and 2 (-4.74%; p = 0.0008). It reduced melanin concentration even further between the prepeeling period and visit 2 (-7.8%; p < 0.0001). Patients rated the depigmentation topical treatment program as "very simple" (87.5%) and "simple" (12.5%) to use and as "pleasant" (56.25%) and "very pleasant" (43.75%). Results support the use of the home-based depigmentation topical treatment program to potentiate the effectiveness of a previous chemical peeling in hyperpigmentation reduction.

化学脱皮可减轻皮肤色素沉着;然而,一旦它的减薄作用耗尽,脱色过程不会继续进一步。我们进行了一项单中心、前瞻性、非对照研究,目的是评估先前进行过化学脱皮的女性脱皮局部治疗方案的有效性、安全性、易用性、舒适性和耐受性。16名妇女在纳入研究前7天内接受含有水杨酸、丙酮酸和视黄酸固定剂量组合的化学脱皮,每天给予局部治疗,持续30天。在脱皮前、研究访问1(脱皮后)和2(治疗30天后)对目标皮肤区域的黑色素浓度和皮肤质地进行评估。局部治疗方案导致黑色素浓度在研究访问1和2之间下降(-4.74%;P = 0.0008)。在去皮前和第2次访问期间,它进一步降低了黑色素浓度(-7.8%;P < 0.0001)。患者评价脱色局部治疗方案“非常简单”(87.5%)和“简单”(12.5%)使用,“愉快”(56.25%)和“非常愉快”(43.75%)。结果支持使用家庭为基础的脱色局部治疗方案,以增强以前的化学脱皮在减少色素沉着的有效性。
{"title":"A Topical Depigmentation Program Against Hyperpigmentation Enhances the Benefits of Previously Performed Chemical Peeling Procedures of the Face.","authors":"Maurizio Cavallini,&nbsp;Fabio Montanaro,&nbsp;Marco Papagni","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Chemical peeling can reduce skin hyperpigmentation; however, once exhausted its thinning action, the depigmentation process does not continue further. We carried out a monocentric, prospective, noncontrolled study aimed at the evaluation of the efficacy, safety, ease of use, pleasantness, and tolerability of a depigmentation topical treatment program in women submitted to a previous chemical peeling. The topical treatment has been administered daily for 30 days to 16 women submitted to a chemical peeling containing a fixed-dose combination of salicylic acid, pyruvic acid, and retinoic acid within 7 days before study inclusion. Target skin areas have been evaluated for melanin concentration and skin texture before peeling and at study visits 1 (after peeling) and 2 (after the 30-day treatment). The topical treatment program induced a decrease in melanin concentration between study visits 1 and 2 (-4.74%; <i>p</i> = 0.0008). It reduced melanin concentration even further between the prepeeling period and visit 2 (-7.8%; <i>p</i> < 0.0001). Patients rated the depigmentation topical treatment program as \"very simple\" (87.5%) and \"simple\" (12.5%) to use and as \"pleasant\" (56.25%) and \"very pleasant\" (43.75%). Results support the use of the home-based depigmentation topical treatment program to potentiate the effectiveness of a previous chemical peeling in hyperpigmentation reduction.</p>","PeriodicalId":15523,"journal":{"name":"Journal of cosmetic science","volume":"71 6","pages":"385-397"},"PeriodicalIF":0.4,"publicationDate":"2020-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38795832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Antibacterial Activity of Senkyunolide A Isolated from Cnidium Officinale Extract. 蛇床子提取物仙球内酯A的抗菌活性研究。
IF 0.4 4区 医学 Q4 CHEMISTRY, APPLIED Pub Date : 2020-11-01
Tae Y Kim, Hyuk C Kwon, Sang Y Lee, Chun M Lee, Kwang S Lee, Kun K Lee

In this study, we investigated the antibacterial and anti-inflammatory properties of Cnidium officinale hexane (COH) extract and senkyunolide A (SA). The antibacterial activities were measured using the paper disk diffusion method and minimum inhibitory concentration (MIC) against Propionibacterium acnes and Malassezia furfur. COH extract showed antibacterial activity at a concentration of 50 mg ml-1. The MICs of COH and SA were determined using the broth microdilution method. COH was found to be active on all the bacteria tested (10 ≤ MIC ≤ 20 mg ml-1). SA showed antibacterial activity against P. acnes. The anti-inflammatory properties were determined using a pancreatic lipase inhibition activity method, lipoxygenase inhibition activity, and inhibition of nitric oxide production activity. COH and SA inhibited the production of nitric oxide by up to 50 µg ml-1 in a dose-dependent manner. COH and SA possess antibacterial and anti-inflammatory activities. They could be used as antibacterial ingredients in various industries.

本研究研究了蛇床子己烷(COH)提取物和蛇床子内酯A (SA)的抗菌和抗炎作用。采用纸片扩散法和最低抑菌浓度(MIC)对痤疮丙酸杆菌和毛马拉色菌进行抑菌活性测定。COH提取物在浓度为50 mg ml-1时具有抗菌活性。采用肉汤微量稀释法测定COH和SA的mic。COH对所有被试细菌均有活性(10≤MIC≤20 mg ml-1)。SA对痤疮假单胞菌具有抑菌活性。采用胰脂肪酶抑制活性法、脂氧合酶抑制活性法和抑制一氧化氮生成活性法测定其抗炎特性。COH和SA以剂量依赖性的方式抑制一氧化氮的产生,抑制量高达50µg ml-1。COH和SA具有抗菌和抗炎活性。它们可以作为抗菌成分应用于各个行业。
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引用次数: 0
Soothing Effect of Pogostemon cablin Extract (Patchouli), via Cannabinoid Receptor 2 Modulation in Human Skin. 广藿香提取物通过人体皮肤大麻素受体2调节的舒缓作用。
IF 0.4 4区 医学 Q4 CHEMISTRY, APPLIED Pub Date : 2020-11-01
Florian Labarrade, Armelle Perrin, Yolene Ferreira, Gilles Oberto, Catherine Gondran, Corinne Morel, Karine Cucumel

Skin functions as a neuro-immuno-endocrine tissue with well-defined neuronal networks and functions. The endocannabinoid system has been proven to be an important, homeostatic regulator for homeostatic and inflammatory events. The system comprises endogenous or exogenous ligands and receptors (CB1 and CB2). In the present study, we evaluated the soothing properties of a Pogostemon cablin (patchouli) extract. Agonist AM1241 and antagonist AM630 were used for CB2 receptor activation/inhibition. Expression of CB2 receptor and β-endorphin was monitored by immunohistochemistry. Skin inflammation was induced with ultraviolet B (UVB) or lipopolysaccharide (LPS), and the following markers were used to highlight the anti-inflammatory properties of the extract: transient receptor potential vanilloid 1 (TRPV1), interleukin receptors 1 (IL1R1), and the interleukin 6 signal transducer (IL6ST). Our results demonstrated the implication of the CB2 receptor in the skin inflammation process. The expression of CB2 receptor and β-endorphin was increased 48 hours after application of the extract. Furthermore, patchouli extract application helped to reduce IL1R1, IL6ST, and TRPV1 expression, in skin exposed to UVB or LPS. In conclusion, the application of the patchouli extract helps maintain skin integrity and reduce skin discomfort via modulation of CB2 receptor stimulation and the subsequent β-endorphin release.

皮肤是一个神经免疫内分泌组织,具有明确的神经网络和功能。内源性大麻素系统已被证明是一个重要的,稳态调节稳态和炎症事件。该系统包括内源性或外源性配体和受体(CB1和CB2)。在本研究中,我们评估了广藿香提取物的舒缓特性。使用激动剂AM1241和拮抗剂AM630激活/抑制CB2受体。免疫组织化学检测CB2受体和β-内啡肽的表达。用紫外线B (UVB)或脂多糖(LPS)诱导皮肤炎症,并使用以下标记来突出提取物的抗炎特性:瞬时受体电位香草素1 (TRPV1),白细胞介素受体1 (IL1R1)和白细胞介素6信号换能器(IL6ST)。我们的研究结果证明了CB2受体在皮肤炎症过程中的作用。CB2受体和β-内啡肽的表达在给药48 h后升高。此外,广藿香提取物有助于降低暴露于UVB或LPS的皮肤中IL1R1, IL6ST和TRPV1的表达。综上所述,广藿香提取物通过调节CB2受体刺激和随后的β-内啡肽释放,有助于保持皮肤完整性,减少皮肤不适。
{"title":"Soothing Effect of <i>Pogostemon cablin</i> Extract (Patchouli), via Cannabinoid Receptor 2 Modulation in Human Skin.","authors":"Florian Labarrade,&nbsp;Armelle Perrin,&nbsp;Yolene Ferreira,&nbsp;Gilles Oberto,&nbsp;Catherine Gondran,&nbsp;Corinne Morel,&nbsp;Karine Cucumel","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Skin functions as a neuro-immuno-endocrine tissue with well-defined neuronal networks and functions. The endocannabinoid system has been proven to be an important, homeostatic regulator for homeostatic and inflammatory events. The system comprises endogenous or exogenous ligands and receptors (CB1 and CB2). In the present study, we evaluated the soothing properties of a <i>Pogostemon cablin</i> (patchouli) extract. Agonist AM1241 and antagonist AM630 were used for CB2 receptor activation/inhibition. Expression of CB2 receptor and β-endorphin was monitored by immunohistochemistry. Skin inflammation was induced with ultraviolet B (UVB) or lipopolysaccharide (LPS), and the following markers were used to highlight the anti-inflammatory properties of the extract: transient receptor potential vanilloid 1 (TRPV1), interleukin receptors 1 (IL1R1), and the interleukin 6 signal transducer (IL6ST). Our results demonstrated the implication of the CB2 receptor in the skin inflammation process. The expression of CB2 receptor and β-endorphin was increased 48 hours after application of the extract. Furthermore, patchouli extract application helped to reduce IL1R1, IL6ST, and TRPV1 expression, in skin exposed to UVB or LPS. In conclusion, the application of the patchouli extract helps maintain skin integrity and reduce skin discomfort <i>via</i> modulation of CB2 receptor stimulation and the subsequent β-endorphin release.</p>","PeriodicalId":15523,"journal":{"name":"Journal of cosmetic science","volume":"71 6","pages":"425-437"},"PeriodicalIF":0.4,"publicationDate":"2020-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38796284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Detection and Analysis of Ceramide in Skin and Blood in a Healthy Chinese Population. 中国健康人群皮肤和血液中神经酰胺的检测与分析。
IF 0.4 4区 医学 Q4 CHEMISTRY, APPLIED Pub Date : 2020-11-01
Cong Xin, Yaochi Wang, Yuling Chang, B O Zhang, Sen Yang

To explore the significance of ceramide in the skin barrier and its potential utility within the cosmetics industry, an accurate and high-speed method was used to detect the types of ceramides in the skin and blood of a healthy Chinese population. Forearm cortical skin stratum corneum samples were obtained from four healthy subjects using a noninvasive method. In addition, these subjects were collected intravenously to obtain blood samples. Ceramides were detected in skin and blood samples using high-performance liquid chromatography coupled with specialized high-resolution Fourier Transform mass spectrometry machine. Data were analyzed using full-flow lipid analysis software. Peaks representing ceramides were detected in all skin samples and some blood samples. The results show that ceramides in skin are predominantly long-chain ceramides, but mainly short-chain in the blood. Simple and fast qualitative and quantitative analysis of ceramide in the skin and blood provides a basis for the precise addition of ceramide in future skin care products and the metabolic regulation and prevention of various diseases.

为了探讨神经酰胺在皮肤屏障中的意义及其在化妆品工业中的潜在用途,采用一种准确、快速的方法检测了中国健康人群皮肤和血液中的神经酰胺类型。采用无创方法获取4名健康受试者前臂皮质皮肤角质层样本。此外,这些受试者被静脉采集血液样本。利用高效液相色谱和专用高分辨率傅里叶变换质谱仪检测皮肤和血液样品中的神经酰胺。数据分析采用全流式脂质分析软件。在所有皮肤样本和一些血液样本中检测到代表神经酰胺的峰。结果表明,皮肤中的神经酰胺以长链神经酰胺为主,而血液中的神经酰胺以短链神经酰胺为主。对皮肤和血液中的神经酰胺进行简单快速的定性和定量分析,为今后护肤品中神经酰胺的精准添加以及代谢调节和预防各种疾病提供了依据。
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引用次数: 0
期刊
Journal of cosmetic science
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