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499 Physiological and Metabolomic Effects of a Community-Based Cardiorenal Protective Diet Intervention in African Americans with Chronic Kidney Disease and Hypertension 499 基于社区的心肾保护性饮食干预对患有慢性肾病和高血压的非裔美国人的生理和代谢影响
IF 2.6 Q3 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2024-04-03 DOI: 10.1017/cts.2024.423
Meera J. Patel, Xuan Wang, Baylor Scott, White Health Teodoro Bottiglieri, Baylor Scott & White Health Heather Kitzman

OBJECTIVES/GOALS: Chronic kidney disease (CKD) impacts 15% of US adults and African American (AA) persons are disproportionately affected with more than 3 times higher risk of kidney failure when compared to Caucasian persons. This study evaluated the physiological and metabolomic effects of increased fruits and vegetables (F&V) on cardio-renal risk factors. METHODS/STUDY POPULATION: This pilot trial used a prospective, 2-group, randomized study design to evaluate a F&V intervention (N=46), where participants received a prescribed amount of fresh, base-producing F&V compared to a wait-list control (WL) condition (N=45). All participants were African American adults (≥18 years), had self-reported hypertension, and had CKD (Stage 1-3) on screening spot-urine microalbumin test. Participants were measured at baseline and 6 weeks post-intervention. Clinical data (i.e., systolic and diastolic blood pressure, lipid panel, hemoglobin A1C, BMI [body mass index], and albumin to creatinine ratio) were collected. Targeted metabolomic quantitative analysis was performed followed by LC-MS/MS and FIA-MS/MS. Linear mixed models evaluated analyte expression and clinical data. RESULTS/ANTICIPATED RESULTS: AA participants (N=91) were aged 58 ± 10.2 years, 66% female, and 54% had incomes ≤$50,000. T-tests compared change scores (baseline to 6-weeks) between groups. The F&V group demonstrated a significant reduction in BMI of -4.7 ± 10.5 kg/m² compared to a 1.9 ± 8.3 kg/m² increase in the WL group, p<.01. Further, the F&V group demonstrated a reduction in total cholesterol of -15.4 ± 58.8 mg/dL compared to a 17.7 ± 68.8 mg/dL increase in the WL group, p<.05. Non-significant reductions in hemoglobin A1c were found in the F&V versus the WL group. Metabolomic analysis indicated significant variation with an increase of suggestive key biomarkers for worse CKD in the WL versus F&V groups at 6-weeks. DISCUSSION/SIGNIFICANCE: Consumption of only 2 cups of F&V via a community-based intervention reduced CVD risk factors in AA adults with CKD and HTN and resulted in molecular/biochemical changes which may improve long-term kidney health. Further investigation may lead to development of cost-effective dietary intervention models to improve CKD outcomes in AA persons.

目的/目标:慢性肾脏病(CKD)影响着 15%的美国成年人,而非洲裔美国人(AA)受到的影响尤为严重,与白种人相比,他们患肾衰竭的风险高出 3 倍多。本研究评估了增加水果和蔬菜(F&V)对心肾风险因素的生理和代谢影响。方法/研究人群:这项试点试验采用前瞻性、两组随机研究设计,评估水果和蔬菜干预措施(N=46),与等待对照(WL)条件(N=45)相比,参与者接受规定量的新鲜、基本生产的水果和蔬菜。所有参与者均为非洲裔美国成年人(≥18 岁),自述患有高血压,并在筛查中接受了定点尿微量白蛋白检测,结果显示患有慢性肾脏病(1-3 期)。参与者在基线和干预后 6 周接受测量。收集了临床数据(即收缩压和舒张压、血脂组合、血红蛋白 A1C、BMI[体重指数]和白蛋白与肌酐比值)。采用 LC-MS/MS 和 FIA-MS/MS 进行了目标代谢组学定量分析。线性混合模型评估了分析物的表达和临床数据。结果/预期结果:AA 参与者(N=91)年龄为 58 ± 10.2 岁,66% 为女性,54% 收入低于 50,000 美元。通过 T 检验比较了各组之间的得分变化(从基线到 6 周)。F&V组的体重指数显著下降,为-4.7 ± 10.5 kg/m²,而WL组则增加了1.9 ± 8.3 kg/m²,p<.01。此外,F&V 组的总胆固醇降低了 -15.4 ± 58.8 mg/dL,而 WL 组增加了 17.7 ± 68.8 mg/dL,p<.05。F&V 组与 WL 组相比,血红蛋白 A1c 下降不明显。代谢组学分析表明,在 6 周时,WL 组与 F&V 组相比,存在明显差异,提示 CKD 恶化的关键生物标志物有所增加。讨论/意义:通过社区干预,仅饮用 2 杯 F&V 可降低患有慢性肾脏病和高血压的 AA 成人的心血管疾病风险因素,并导致分子/生化变化,从而改善长期肾脏健康。进一步的调查可能会开发出具有成本效益的饮食干预模式,以改善 AA 族人的 CKD 结果。
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引用次数: 0
362 Examining Temporal Links Between Distinct Negative Emotions and Tobacco Lapse During A Cessation Attempt 362 在尝试戒烟过程中,研究不同负面情绪与烟瘾发作之间的时间联系
IF 2.6 Q3 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2024-04-03 DOI: 10.1017/cts.2024.321
Dusti Jones, Lindsey N. Potter, Cho Y. Lam, David W. Wetter
OBJECTIVES/GOALS: Negative emotions (NE) play a pivotal role in addiction-related processes, including tobacco lapse during a quit attempt. Some NEs (e.g., shame, guilt) are posited to lead to a spiraling effect, whereby lapse predicts increased NEs leading to further lapse. This study goal is to examine associations between NEs and lapse. METHODS/STUDY POPULATION: This study examined associations between tobacco lapse and 13 distinct NEs among people who use tobacco and are trying to quit in two tobacco cessation studies. In Study 1, 220 adult (ages 18-74) cigarette users who identified as Black (50% female) participated in a 14-day study where ecological momentary assessment (with assessments approximately every 4 hours) was used to assess emotions and lapse in real-time and real-world settings. In Study 2, 288 adult (ages 18-71) cigarette users who were low socioeconomic status (51% White, 14% Black, 10% Hispanic, 49% female) participated in a 14-day study with the same study protocol as Study 1. Between and lagged within-person associations testing links between distinct NEs and lapse were examined with multilevel modeling with logistic links for binary outcomes. RESULTS/ANTICIPATED RESULTS: Results from Study 1 suggested that at the between-person level, disgust (OR =1.22, CI: 1.05, 1.42), nervousness (OR=1.23, CI:1.05,1.43), guilt (OR=1.40, CI: 1.16,1.69), and sadness (OR=1.18, CI:1.02,1.36) were predictive of higher odds of lapse, and at the within-person level, shame (OR=1.23, CI:1.04,1.45) was associated with higher odds of lapse. Results from Study 2 were similar and suggested that at the between-person level, disgust (OR=1.35, CI: 1.16, 1.56) and guilt (OR=1.88, CI:1.07,3.30), and at the within-person level, shame (OR =1.31, CI:1.10,1.55), were associated with higher odds of lapse. DISCUSSION/SIGNIFICANCE: The present study uses real-time, real-world data to demonstrate the role of distinct NEs on momentary tobacco lapse and helps elucidate specific NE that hinder the ability to abstain from tobacco use during a quit attempt. Results suggest that disgust, guilt, and shame play consistent roles in predicting lapse among diverse samples of tobacco users.
目的/目标:负面情绪(NE)在成瘾相关过程中起着关键作用,包括戒烟尝试中的失误。一些消极情绪(如羞耻感、负罪感)被认为会导致一种螺旋效应,即戒烟失败预示着消极情绪的增加,从而导致进一步的戒烟失败。本研究旨在探讨 NEs 与戒烟失败之间的关联。方法/研究人群:本研究在两项戒烟研究中考察了烟草失效与试图戒烟的烟草使用者中13种不同NE之间的关系。在研究 1 中,220 名自认为是黑人的成年(18-74 岁)吸烟者(50% 为女性)参加了为期 14 天的研究,该研究采用生态瞬间评估(大约每 4 小时评估一次)来评估实时和真实世界环境中的情绪和失效情况。在研究 2 中,288 名社会经济地位较低的成年(18-71 岁)烟民(51% 白人、14% 黑人、10% 西班牙人、49% 女性)参加了为期 14 天的研究,研究方案与研究 1 相同。通过二元结果的逻辑关联多层次建模,检验了不同NE与失效之间的人际关联和滞后人内关联。结果/预期结果:研究 1 的结果表明,在人与人之间,厌恶(OR =1.22,CI:1.05, 1.42)、紧张(OR=1.23,CI:1.05,1.43)、内疚(OR=1.40,CI:1.在个人层面上,羞耻感(OR=1.23,CI:1.04,1.45)与较高的失眠几率相关。研究 2 的结果与此类似,表明在人与人之间,厌恶感(OR=1.35,CI:1.16,1.56)和内疚感(OR=1.88,CI:1.07,3.30)以及在人与人之间,羞耻感(OR=1.31,CI:1.10,1.55)与较高的失恋几率相关。讨论/意义:本研究利用真实世界的实时数据证明了不同的NE对瞬间烟草失效的作用,并有助于阐明在戒烟尝试中阻碍戒烟能力的特定NE。研究结果表明,在不同的烟草使用者样本中,厌恶、负罪感和羞耻感在预测失效方面发挥着一致的作用。
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引用次数: 0
524 Navigator: Providing a foundation for cross team collaboration and custom research service through the CTSA Hub 524 导航器:通过 CTSA Hub 为跨团队合作和定制研究服务奠定基础
IF 2.6 Q3 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2024-04-03 DOI: 10.1017/cts.2024.446
Kitt Swartz, Matt Honoré, Kimberly Cook, Heidi Funderburgh, Cynthia Morris, David Ellison
OBJECTIVES/GOALS: The Oregon Clinical and Translational Research Institute (OCTRI) Clinical Research Navigator program provides a single point of entry for clinical and translational research services, support, advice and guidance. We provide data to illustrate the Navigator model at OHSU and examine continued opportunities to optimize research resources. METHODS/STUDY POPULATION: Requests and activities performed by the OCTRI Navigator program, staffed by 3 FTE (2 Assistant Navigators and 1 Assistant Director) were analyzed. Navigator receives requests through multiple methods: a digital form (REDCap®), email, phone calls. Requests for services and support include focused need for a core or a broad request for multiple services for start-up: informatics, the clinical and translational research center, regulatory knowledge and support, recruitment, qualitative methods, community research, biostatistics or broad consultations. Requests are tracked in SPARCRequest. Navigator also supports wayfinding to institutional resources outside of the CTSA, matchmaking for sponsors seeking investigators, and serves as a connector and facilitator across programs. RESULTS/ANTICIPATED RESULTS: OCTRI Clinical Research Navigator triaged an average of 964 research requests for 613 projects with 388 unique investigators annually between 2018-2022. Navigator also fields more than 80 calls each year that are unrelated to CTSA projects. Project requests are examined to illustrate trends in projects requesting multiple services and display how Navigator simplifies project intake and connects researchers to resources they may have not recognized they needed. Project attributes including funding type and funding status are included in this review. DISCUSSION/SIGNIFICANCE: CTSA resources are essential to the infrastructure available to researchers. While absolute numbers of requests provide little insight into the impact each CTSA hub may have, the timing and clustering trends of projects with multiple program requests shows how a combination of technology and experienced staff can efficiently support researchers.
目标/目的:俄勒冈州临床与转化研究所(Oregon Clinical and Translational Research Institute,OCTRI)的临床研究导航计划为临床与转化研究服务、支持、建议和指导提供了一个单一的切入点。我们提供数据来说明俄勒冈州立卫生大学的导航员模式,并研究优化研究资源的持续机会。方法/研究对象:我们分析了由 3 名全职员工(2 名助理导航员和 1 名助理主任)组成的 OCTRI 导航计划提出的请求和开展的活动。导航员通过多种方式接收请求:数字表格 (REDCap®)、电子邮件和电话。对服务和支持的请求包括对核心服务的重点需求或对多种服务的广泛请求,如信息学、临床和转化研究中心、监管知识和支持、招聘、定性方法、社区研究、生物统计或广泛咨询。请求在 SPARCRequest 中进行跟踪。导航仪还支持为 CTSA 以外的机构资源寻路,为寻找研究人员的赞助商牵线搭桥,并充当跨项目的连接器和促进者。结果/预期结果:2018-2022 年间,OCTRI 临床研究导航员平均每年为 613 个项目的 388 名研究者分流 964 份研究请求。导航员每年还接到 80 多个与 CTSA 项目无关的电话。对项目请求进行审查,以说明请求多种服务的项目趋势,并展示 Navigator 如何简化项目受理,以及如何将研究人员与他们可能没有意识到的所需资源联系起来。项目属性包括资金类型和资金状态。讨论/意义:CTSA 资源对研究人员可用的基础设施至关重要。虽然申请的绝对数量无法让人深入了解每个 CTSA 中心可能产生的影响,但具有多个计划申请的项目的时间和集群趋势表明,技术与经验丰富的员工相结合可以有效地为研究人员提供支持。
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引用次数: 0
281 Catalyzing Community and Stakeholder Engagement (CSE) in Research: Perspectives from Scientist and Stakeholder Experience 281 在研究中促进社区和利益相关者的参与(CSE):科学家和利益相关者的经验视角
IF 2.6 Q3 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2024-04-03 DOI: 10.1017/cts.2024.257
Siyu Chen, Sarah K. Brewer, Robert Sege, Aviva Must, Nadia Prokofieva, Thomas W. Concannon, Alice Rushforth, Lisa Welch

OBJECTIVES/GOALS: Community and other stakeholder engagement (CSE) is critical for relevant and equitable clinical research, yet implementation poses challenges. This study delineates the perspectives of scientists and diverse stakeholders regarding facilitators and challenges in CSE, its perceived value, and their recommendations for successful CSE. METHODS/STUDY POPULATION: The Tufts CTSI Pilot Studies Program requires applicants to propose a plan for CSE while implementing the award, including which stakeholders (SHs)—community members, clinicians, and others affected by the research--will be involved and at what stages. This qualitative study assessed the experiences of both Principal Investigators (PIs) and SHs engaged in pilot projects from three cohorts of awardees (2019-21). Recruitment targeted one PI and one SH per project. Semi-structured interviews explored their CSE experiences, including facilitators, challenges, meaningfulness, perceived impact, intent to participate in CSE in future studies, as well as recommendations for funders, research support organizations, and investigators. Inductive consensus-based coding and thematic analysis was employed. RESULTS/ANTICIPATED RESULTS: Fourteen PIs from different pilot projects and a SH from five of these projects participated. Almost all PIs (92%) had over six years of experience, but two-thirds (67%) had little or no experience with CSE. Four SHs self-identified as representatives of community organizations and one as a clinician scientist. CSE was a “win-win” for both PIs and SHs, and all PIs intended to involve SHs in other research studies. Three facilitators were identified as fostering effective CSE (e.g., PI access to CSE expertise while conducting the project), while four challenges hindered it (e.g., limits on SH capacity and CSE funding). SHs advised scientists to build authentic, sustained relationships, and PIs and SHs provided three actionable recommendations for funders and research support organizations to deepen and expand CSE. DISCUSSION/SIGNIFICANCE: Perspectives of scientists and SHs engaged in research projects are vital for expanding and sustaining effective CSE in research. Funders and research support organizations can enhance their strategies for CSE integration in clinical and translational research by incorporating these diverse views to ensure the research achieves maximal impact.

目的/目标:社区和其他利益相关者的参与(CSE)对于相关和公平的临床研究至关重要,但在实施过程中却面临挑战。本研究阐述了科学家和不同利益相关者对 CSE 的促进因素和挑战、其认知价值的看法,以及他们对成功 CSE 的建议。方法/研究对象:塔夫茨 CTSI 试点研究计划要求申请者在获奖的同时提出 CSE 计划,包括哪些利益相关者(SHs)--社区成员、临床医生和其他受研究影响的人--将参与其中,以及在哪些阶段参与。本定性研究评估了三批获奖者(2019-21 年)中参与试点项目的首席研究员 (PI) 和 SHs 的经验。每个项目招募一名首席研究员和一名高级研究员。半结构式访谈探讨了他们的 CSE 经验,包括促进因素、挑战、意义、感知的影响、在未来研究中参与 CSE 的意向,以及对资助者、研究支持机构和研究人员的建议。研究采用了基于共识的归纳编码和主题分析方法。结果/预期结果:来自不同试点项目的 14 位首席研究员和其中 5 个项目的一位 SH 参与了研究。几乎所有首席研究员(92%)都有六年以上的工作经验,但三分之二(67%)的首席研究员几乎没有或根本没有 CSE 经验。四位 SH 自认为是社区组织的代表,一位是临床科学家。CSE 对首席研究员和 SHs 来说是 "双赢 "的,所有首席研究员都打算让 SHs 参与其他研究。有三个促进因素被认为有助于有效地开展 CSE(例如,首席研究员在开展项目的同时可以获得 CSE 的专业知识),而有四个挑战则阻碍了 CSE 的开展(例如,对 SH 能力和 CSE 资金的限制)。科研人员建议科学家建立真实、持续的关系,而首席研究员和科研人员则为资助者和研究支持机构提供了三项可行建议,以深化和扩大 CSE。讨论/意义:参与研究项目的科学家和 SHs 的观点对于在研究中扩大和维持有效的 CSE 至关重要。资助者和研究支持机构可以通过采纳这些不同的观点,加强其在临床和转化研究中整合 CSE 的策略,以确保研究取得最大的影响。
{"title":"281 Catalyzing Community and Stakeholder Engagement (CSE) in Research: Perspectives from Scientist and Stakeholder Experience","authors":"Siyu Chen, Sarah K. Brewer, Robert Sege, Aviva Must, Nadia Prokofieva, Thomas W. Concannon, Alice Rushforth, Lisa Welch","doi":"10.1017/cts.2024.257","DOIUrl":"https://doi.org/10.1017/cts.2024.257","url":null,"abstract":"<p>OBJECTIVES/GOALS: Community and other stakeholder engagement (CSE) is critical for relevant and equitable clinical research, yet implementation poses challenges. This study delineates the perspectives of scientists and diverse stakeholders regarding facilitators and challenges in CSE, its perceived value, and their recommendations for successful CSE. METHODS/STUDY POPULATION: The Tufts CTSI Pilot Studies Program requires applicants to propose a plan for CSE while implementing the award, including which stakeholders (SHs)—community members, clinicians, and others affected by the research--will be involved and at what stages. This qualitative study assessed the experiences of both Principal Investigators (PIs) and SHs engaged in pilot projects from three cohorts of awardees (2019-21). Recruitment targeted one PI and one SH per project. Semi-structured interviews explored their CSE experiences, including facilitators, challenges, meaningfulness, perceived impact, intent to participate in CSE in future studies, as well as recommendations for funders, research support organizations, and investigators. Inductive consensus-based coding and thematic analysis was employed. RESULTS/ANTICIPATED RESULTS: Fourteen PIs from different pilot projects and a SH from five of these projects participated. Almost all PIs (92%) had over six years of experience, but two-thirds (67%) had little or no experience with CSE. Four SHs self-identified as representatives of community organizations and one as a clinician scientist. CSE was a “win-win” for both PIs and SHs, and all PIs intended to involve SHs in other research studies. Three facilitators were identified as fostering effective CSE (e.g., PI access to CSE expertise while conducting the project), while four challenges hindered it (e.g., limits on SH capacity and CSE funding). SHs advised scientists to build authentic, sustained relationships, and PIs and SHs provided three actionable recommendations for funders and research support organizations to deepen and expand CSE. DISCUSSION/SIGNIFICANCE: Perspectives of scientists and SHs engaged in research projects are vital for expanding and sustaining effective CSE in research. Funders and research support organizations can enhance their strategies for CSE integration in clinical and translational research by incorporating these diverse views to ensure the research achieves maximal impact.</p>","PeriodicalId":15529,"journal":{"name":"Journal of Clinical and Translational Science","volume":"4 1","pages":""},"PeriodicalIF":2.6,"publicationDate":"2024-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140581281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
110 Answering the Call for Greater LGBTQ+ Research Inclusivity by Co-Developing A Workshop for Researchers 110 共同开发研究人员讲习班,响应提高 LGBTQ+ 研究包容性的号召
IF 2.6 Q3 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2024-04-03 DOI: 10.1017/cts.2024.108
Gelise Thomas, Lizzie Bjork, Zina Hempstead, Gulnar Feerasta

OBJECTIVES/GOALS: The objectives of this workshop were to: (1) provide learners with a space to become aware of and discuss the history of the LGBTQ+ community in medical and public health research; (2) apply frameworks for LGBTQ+ inclusivity in research, inspired by lived experience and multimedia; and (3) assess LGBTQ+ research inclusivity best practices. METHODS/STUDY POPULATION: The CTSC provided the LGBT Community Center of Greater Cleveland (Center) with access to academic resources via an affiliate account and insights on the clinical and translational science research process. Members of the CTSC Research Equity, Accessibility, Diversity, and Inclusion team met regularly with the education and programming team at the Center to review research findings for workshop segments, ideate and provide feedback on activities, and strategize to ensure a psychologically safe virtual environment for learners. Zoom registration was used for workshop registration. An evaluation survey, created by the LGBT Community Center of Greater Cleveland (Center), was deployed by the CTSC to learners after the workshop. Respondents reported that the LGBTQ+ terminology focus was most valuable. RESULTS/ANTICIPATED RESULTS: To maximize investment in and scale theLGBTQ+ Inclusivity For Researchers workshop, the LGBT Community Center of Greater Cleveland offered a shortened version to their Youth Participatory Action Research group and will continue to offer the workshop in their suite of program/educational offerings. The CTSC plans to offer opportunities to co-host the workshop at its hospital system partner institutions, with room to tailor content based on internal LGBT resources (e.g., gender care offered at the institution). We hope to see a remarkable increase in LGBTQ+ identifying researchers, LGBTQ+ participation in research studies and clinical trials, and LGBTQ+ research topics/ideas/questions in response to CTSC pilots, local, national, and global funding opportunities. DISCUSSION/SIGNIFICANCE: LGBTQ+ people are less likely to have a regular health care provider—impeding screening, diagnosis, and treatment. This is reflected in health research where clinical research participation may follow a diagnosis. By providing tools for LGBTQ+ research inclusion, we will catalyze more research with LGBTQ+ people—as researchers and participants.

目的/目标:本次研讨会的目标是(1) 为学习者提供一个了解和讨论 LGBTQ+ 社区在医学和公共卫生研究中的历史的空间;(2) 在生活经验和多媒体的启发下,在研究中应用 LGBTQ+ 包容性框架;(3) 评估 LGBTQ+ 研究包容性的最佳实践。方法/研究对象:CTSC 通过附属帐户向大克利夫兰地区 LGBT 社区中心(中心)提供学术资源,并提供临床和转化科学研究过程方面的见解。CTSC 研究公平性、无障碍性、多样性和包容性团队的成员定期与该中心的教育和编程团队会面,审查研讨会环节的研究成果,对活动进行构思和提供反馈,并制定战略以确保为学习者提供心理安全的虚拟环境。讲习班注册采用 Zoom 注册方式。大克利夫兰地区 LGBT 社区中心(以下简称 "中心")制作了一份评估调查表,由 CTSC 在研讨会结束后分发给学员。受访者认为 LGBTQ+ 术语最有价值。结果/预期结果:为了最大限度地投资和推广 LGBTQ+ 研究人员包容性研讨会,大克利夫兰地区 LGBT 社区中心为其青年参与行动研究小组提供了一个简短版本,并将继续在其项目/教育课程中提供该研讨会。CTSC 计划在其医院系统的合作机构中提供共同举办该研讨会的机会,并可根据内部 LGBT 资源(如机构中提供的性别护理)调整研讨会内容。我们希望看到 LGBTQ+ 研究人员、LGBTQ+ 参与研究和临床试验的人数以及 LGBTQ+ 研究课题/想法/问题都能显著增加,以响应 CTSC 试点项目、地方、国家和全球资助机会。讨论/意义:LGBTQ+人群不太可能拥有固定的医疗服务提供者,这阻碍了筛查、诊断和治疗。这反映在健康研究中,临床研究的参与可能是在诊断之后。通过提供将 LGBTQ+ 纳入研究的工具,我们将促进更多与 LGBTQ+ 相关的研究--研究者和参与者。
{"title":"110 Answering the Call for Greater LGBTQ+ Research Inclusivity by Co-Developing A Workshop for Researchers","authors":"Gelise Thomas, Lizzie Bjork, Zina Hempstead, Gulnar Feerasta","doi":"10.1017/cts.2024.108","DOIUrl":"https://doi.org/10.1017/cts.2024.108","url":null,"abstract":"<p>OBJECTIVES/GOALS: The objectives of this workshop were to: (1) provide learners with a space to become aware of and discuss the history of the LGBTQ+ community in medical and public health research; (2) apply frameworks for LGBTQ+ inclusivity in research, inspired by lived experience and multimedia; and (3) assess LGBTQ+ research inclusivity best practices. METHODS/STUDY POPULATION: The CTSC provided the LGBT Community Center of Greater Cleveland (Center) with access to academic resources via an affiliate account and insights on the clinical and translational science research process. Members of the CTSC Research Equity, Accessibility, Diversity, and Inclusion team met regularly with the education and programming team at the Center to review research findings for workshop segments, ideate and provide feedback on activities, and strategize to ensure a psychologically safe virtual environment for learners. Zoom registration was used for workshop registration. An evaluation survey, created by the LGBT Community Center of Greater Cleveland (Center), was deployed by the CTSC to learners after the workshop. Respondents reported that the LGBTQ+ terminology focus was most valuable. RESULTS/ANTICIPATED RESULTS: To maximize investment in and scale theLGBTQ+ Inclusivity For Researchers workshop, the LGBT Community Center of Greater Cleveland offered a shortened version to their Youth Participatory Action Research group and will continue to offer the workshop in their suite of program/educational offerings. The CTSC plans to offer opportunities to co-host the workshop at its hospital system partner institutions, with room to tailor content based on internal LGBT resources (e.g., gender care offered at the institution). We hope to see a remarkable increase in LGBTQ+ identifying researchers, LGBTQ+ participation in research studies and clinical trials, and LGBTQ+ research topics/ideas/questions in response to CTSC pilots, local, national, and global funding opportunities. DISCUSSION/SIGNIFICANCE: LGBTQ+ people are less likely to have a regular health care provider—impeding screening, diagnosis, and treatment. This is reflected in health research where clinical research participation may follow a diagnosis. By providing tools for LGBTQ+ research inclusion, we will catalyze more research with LGBTQ+ people—as researchers and participants.</p>","PeriodicalId":15529,"journal":{"name":"Journal of Clinical and Translational Science","volume":"43 1","pages":""},"PeriodicalIF":2.6,"publicationDate":"2024-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140581297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
15 Discrepancies in Medication Usage and Lifestyle Modification Referrals in Metabolic Syndrome is Dependent on how the Syndrome is Coded: A TriNetX Study 15 代谢综合征的药物使用和生活方式改变转诊中的差异取决于综合征的编码方式:TriNetX 研究
IF 2.6 Q3 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2024-04-03 DOI: 10.1017/cts.2024.36
Annabelle N. Brinkerhoff, Jigar Gosalia, Juan J. Qiu, James A. Pawelczyk, David N. Proctor
OBJECTIVES/GOALS: ICD-10 coding inconsistencies hinder timely recognition and treatment of metabolic syndrome (MetS), posing a significant risk for cardiometabolic disease progression. This study employed a digital phenotype for MetS and compared odds for medication and lifestyle intervention compared to those coded for MetS. METHODS/STUDY POPULATION: MetS is a cluster of cardiometabolic risk factors that increase risk for numerous adverse clinical outcomes. Patients with MetS were identified through electronic medical records on TriNetX LLC using the standard ICD-10 code or through a digital phenotype, involving grouping codes for the individual components. Percentage of patients with MetS not captured with the standard code was identified. In addition, disparities in blood pressure, glucose, lipid-lowering medication, and lifestyle intervention between the coding schemas were assessed, shedding light on healthcare inequities and informing targeted interventions. Odds ratios (RR) were presented for all outcomes. RESULTS/ANTICIPATED RESULTS: Patient demographics and lab values were similar between the standard code and digital phenotype cohorts. Of the 4.3 million individuals aged 50 to 80 identified as having MetS using the digital phenotype in the TriNetX research network, only 1.78% of participants shared the standard code. Individuals with the digital phenotype for MetS were at lower odds in receiving glucose lowering medication (OR: 2.11, 95% CI: 1.98–2.13, p <0.001) and exercise or nutrition-based intervention advice (OR: 1.76, 95% CI: 1.55–1.96, p <0.001) after controlling for demographics and lab values for each MetS component. DISCUSSION/SIGNIFICANCE: This project utilized TriNetX to create a digital phenotype for MetS, and suggests most patients are not coded for it using the standard ICD-10 system. This is troublesome given those with the standard code are less likely to receive certain interventions.
目的/目标:ICD-10 编码的不一致阻碍了对代谢综合征 (MetS) 的及时识别和治疗,给心脏代谢疾病的恶化带来了巨大风险。本研究采用了 MetS 数字表型,并比较了药物治疗和生活方式干预的几率与 MetS 编码的几率。方法/研究对象:MetS 是一组心脏代谢风险因素,会增加多种不良临床结果的风险。MetS 患者是通过 TriNetX LLC 上的电子病历,使用标准 ICD-10 编码或通过数字表型(包括各组成部分的分组编码)确定的。我们还确定了未使用标准代码的 MetS 患者比例。此外,还评估了编码模式之间在血压、血糖、降脂药物和生活方式干预方面的差异,从而揭示了医疗保健的不公平现象,并为有针对性的干预措施提供依据。所有结果的比值比(RR)均已列出。结果/预期结果:标准编码组群和数字表型组群的患者人口统计学特征和化验值相似。在 TriNetX 研究网络中使用数字表型确定的 430 万名 50 至 80 岁的 MetS 患者中,只有 1.78% 的参与者共享标准代码。在控制了MetS各组成部分的人口统计学和实验室值后,具有MetS数字表型的个体接受降糖药物(OR:2.11,95% CI:1.98-2.13,p <0.001)和运动或营养干预建议(OR:1.76,95% CI:1.55-1.96,p <0.001)的几率较低。讨论/意义:该项目利用 TriNetX 创建了 MetS 的数字表型,并表明大多数患者并未使用标准 ICD-10 系统进行编码。这很麻烦,因为有标准编码的患者不太可能接受某些干预措施。
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引用次数: 0
403 Epithelial hypoxia maintains colonization resistance against Candida albicans 403 上皮细胞缺氧可维持对白色念珠菌的定植抵抗力
IF 2.6 Q3 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2024-04-03 DOI: 10.1017/cts.2024.350
Derek J. Bays, Hannah P. Savage, Connor Tiffany, Mariela A. F. Gonzalez, Eli. J. Bejarano, Henry Nguyen, Hugo L. P. Masson, Thaynara P. Carvalho, Renato L. Santos, Andrew Tritt, Suzanne M. Noble, George R. Thompson, Andreas J. Bäumler
OBJECTIVES/GOALS: Antibiotic treatment sets the stage for intestinal domination by Candida albicanswhich is necessary for development of invasive disease, but the resources driving this bloom remain poorly defined. We sought to determine these factors in order to design novel prophylaxis strategies for reducing gastrointestinal (GI) colonization. METHODS/STUDY POPULATION: We initially developed a generalizable framework, termed metabolic footprinting to determine the metabolites C. albicanspreferentially uses in the mouse GI tract. After identifying the metabolites C. albicansutilizes, we usedin vitro growth assays in the presence and absence of oxygen to validate out metabolomics findings. We next determined if a probiotic E. coli that utilizes oxygen would reduce C. albicanscolonization compared to a mutant E. coli that could not respire oxygen. Finding that oxygen was a necessary resource, we utilized germ-free mice to determine if Clostridiaspp. known to reduce GI oxygen would prevent C. albicanscolonization. Lastly, we sought to see if 5-aminosalicylic acid (5-ASA) could prevent C. albicanscolonization. RESULTS/ANTICIPATED RESULTS: We found that C. albicans preferentially utilizes simple carbohydrates including fructo-oligosaccharides (e.g., 1-kestose), disaccharides (e.g., β-gentiobiose), and alcoholic sugars (e.g., sorbitol) and is able to grow in vitro on minimal media supplemented with either of these nutrients. However, in the hypoxic environment that is found in the “healthy” colon, C. albicans cannot utilize these nutrients. We next found that pre-colonization in a mouse model with a probiotic E. coli significantly reduced C. albicanscolonization, but the mutant E. coli had no effect on colonization. We next showed that Clostridia supplementation restored GI hypoxia and reduced C. albicanscolonization. Remarkably, we found that 5-ASA significantly reduced GI colonization of C. albicans. DISCUSSION/SIGNIFICANCE: We have shown that C. albicans requires oxygen to colonize the GI tract. Importantly, we found that 5-ASA can prevent an antibiotic mediated bloom of C. albicans by restoring GI hypoxia, which warrants additional studies to determine if 5-ASA can be used as an adjunctive prophylactic treatment in high risk patients.
目的/目标:抗生素治疗为白色念珠菌统治肠道创造了条件,而白色念珠菌统治肠道是发展侵袭性疾病的必要条件,但驱动这种绽放的资源尚不明确。我们试图确定这些因素,从而设计出减少胃肠道(GI)定植的新型预防策略。方法/研究对象:我们最初开发了一个可通用的框架,称为代谢足迹法,以确定白僵菌在小鼠胃肠道中优先使用的代谢物。确定白僵菌利用的代谢物后,我们使用有氧和无氧条件下的体外生长试验来验证代谢组学的发现。与不能呼吸氧气的突变大肠杆菌相比,我们接下来确定了利用氧气的益生大肠杆菌是否会减少白僵菌的定植。我们发现氧气是一种必要的资源,因此利用无菌小鼠来确定已知能减少胃肠道氧气的梭状芽孢杆菌是否能阻止白僵菌的定殖。最后,我们试图了解 5-氨基水杨酸(5-ASA)是否能阻止白僵菌的定殖。结果/预期结果:我们发现白僵菌优先利用简单碳水化合物,包括果寡糖(如 1-凯斯糖)、双糖(如 β-戊二糖)和醇糖(如山梨醇),并能在补充了这些营养物质的最小培养基上体外生长。然而,在 "健康 "结肠的缺氧环境中,白僵菌无法利用这些营养物质。我们接下来发现,在小鼠模型中使用益生菌大肠杆菌进行预定植可显著减少白僵菌的定植,但突变大肠杆菌对定植没有影响。我们接下来的研究表明,补充梭状芽孢杆菌可恢复胃肠道缺氧并减少白僵菌的定植。值得注意的是,我们发现 5-ASA 能显著减少白僵菌在胃肠道的定植。讨论/意义:我们已经证明,白僵菌需要氧气才能在消化道定植。重要的是,我们发现 5-ASA 可以通过恢复消化道缺氧来防止抗生素介导的白僵菌繁殖,这就需要进行更多的研究,以确定 5-ASA 是否可用作高危患者的辅助预防性治疗。
{"title":"403 Epithelial hypoxia maintains colonization resistance against Candida albicans","authors":"Derek J. Bays, Hannah P. Savage, Connor Tiffany, Mariela A. F. Gonzalez, Eli. J. Bejarano, Henry Nguyen, Hugo L. P. Masson, Thaynara P. Carvalho, Renato L. Santos, Andrew Tritt, Suzanne M. Noble, George R. Thompson, Andreas J. Bäumler","doi":"10.1017/cts.2024.350","DOIUrl":"https://doi.org/10.1017/cts.2024.350","url":null,"abstract":"OBJECTIVES/GOALS: Antibiotic treatment sets the stage for intestinal domination by Candida albicanswhich is necessary for development of invasive disease, but the resources driving this bloom remain poorly defined. We sought to determine these factors in order to design novel prophylaxis strategies for reducing gastrointestinal (GI) colonization. METHODS/STUDY POPULATION: We initially developed a generalizable framework, termed metabolic footprinting to determine the metabolites C. albicanspreferentially uses in the mouse GI tract. After identifying the metabolites C. albicansutilizes, we usedin vitro growth assays in the presence and absence of oxygen to validate out metabolomics findings. We next determined if a probiotic E. coli that utilizes oxygen would reduce C. albicanscolonization compared to a mutant E. coli that could not respire oxygen. Finding that oxygen was a necessary resource, we utilized germ-free mice to determine if Clostridiaspp. known to reduce GI oxygen would prevent C. albicanscolonization. Lastly, we sought to see if 5-aminosalicylic acid (5-ASA) could prevent C. albicanscolonization. RESULTS/ANTICIPATED RESULTS: We found that C. albicans preferentially utilizes simple carbohydrates including fructo-oligosaccharides (e.g., 1-kestose), disaccharides (e.g., β-gentiobiose), and alcoholic sugars (e.g., sorbitol) and is able to grow in vitro on minimal media supplemented with either of these nutrients. However, in the hypoxic environment that is found in the “healthy” colon, C. albicans cannot utilize these nutrients. We next found that pre-colonization in a mouse model with a probiotic E. coli significantly reduced C. albicanscolonization, but the mutant E. coli had no effect on colonization. We next showed that Clostridia supplementation restored GI hypoxia and reduced C. albicanscolonization. Remarkably, we found that 5-ASA significantly reduced GI colonization of C. albicans. DISCUSSION/SIGNIFICANCE: We have shown that C. albicans requires oxygen to colonize the GI tract. Importantly, we found that 5-ASA can prevent an antibiotic mediated bloom of C. albicans by restoring GI hypoxia, which warrants additional studies to determine if 5-ASA can be used as an adjunctive prophylactic treatment in high risk patients.","PeriodicalId":15529,"journal":{"name":"Journal of Clinical and Translational Science","volume":"35 1","pages":""},"PeriodicalIF":2.6,"publicationDate":"2024-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140581352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
230 Assessing the Role of Youth Sports in Diabetes Prevention and Perceived Discrimination 230 评估青少年体育在糖尿病预防中的作用和感知到的歧视
IF 2.6 Q3 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2024-04-03 DOI: 10.1017/cts.2024.212
Leesi George-Komi, Leah Robinson
OBJECTIVES/GOALS: Our study aims to 1) examine the link between engagement in CLR Academy and youth diabetes risk factors—physical activity, nutrition, mental health, and weight status; 2) examine CLR’s role in moderating the relationship between perceived discrimination and these risk factors. Includes a program evaluation of CLR & interviews of members. METHODS/STUDY POPULATION: Youth-onset diabetes is rising in American minority communities. Youth sports programs like the Community Leadership Revolution (CLR) Academy in Washtenaw County, MI are emerging responses to this issue. CLR targets diabetes risk factors through team sports by promoting mindfulness and healthy habits. Employing a mixed-methods, pretest-posttest approach, our study focuses on how the frequency of engagement in CLR impacts CLR’s effect on youth’s diabetes risk factors. Considering the discrimination minority youth experience, we also aim to see if CLR potentially buffers the impact of perceived discrimination on diabetes risk factors. A posttest program evaluation of CLR will also include semi-structured interviews with CLR staff and participants. RESULTS/ANTICIPATED RESULTS: There is potential that youth with high engagement in CLR Academy may see enhanced benefits in managing diabetes risk factors compared to less active participants. This may be particularly true for youth experiencing high perceived discrimination, with potential marked improvements in mental health, like reduced anxiety and depression. Additionally, through a program evaluation and semi-structured interviews, our study aims to uncover the factors contributing to CLR’s success as a community-led intervention while also identifying areas for enhancement. Post-study, CLR will receive financial support to integrate these insights into their program, furthering their effectiveness in youth diabetes prevention and overall well-being. DISCUSSION/SIGNIFICANCE: This study may provide significant insights into the relationship between sports participation, diabetes risk factors, and perceived discrimination. The findings could help CLR improve its program and guide more effective diabetes prevention strategies in minority youth through other youth sports programs.
目的/目标:我们的研究旨在:1)研究参与 CLR 学院与青少年糖尿病风险因素(体育活动、营养、心理健康和体重状况)之间的联系;2)研究 CLR 在调节感知到的歧视与这些风险因素之间的关系方面所起的作用。包括对 CLR & 的计划评估;对成员的访谈。方法/研究对象:在美国少数民族社区,青少年糖尿病发病率正在上升。密歇根州沃什特瑙县的 "社区领导革命(CLR)学院 "等青年体育项目是应对这一问题的新兴措施。社区领袖革命学院通过团队运动来促进心智和健康习惯的养成,从而消除糖尿病风险因素。我们的研究采用混合方法、前测-后测方法,重点研究参与 CLR 的频率如何影响 CLR 对青少年糖尿病风险因素的影响。考虑到少数族裔青少年受到的歧视,我们还希望了解社区康复是否有可能缓冲感知到的歧视对糖尿病风险因素的影响。对 CLR 的测试后项目评估还将包括对 CLR 工作人员和参与者进行半结构化访谈。结果/预期结果:与不太积极的参与者相比,参与 "CLR 学院 "活动较多的青少年有可能在控制糖尿病风险因素方面获得更多益处。这一点对于遭受严重歧视的青少年尤为明显,他们的心理健康可能会得到明显改善,如焦虑和抑郁情绪有所减轻。此外,通过项目评估和半结构式访谈,我们的研究旨在揭示 CLR 作为社区主导的干预措施取得成功的因素,同时确定需要改进的地方。研究结束后,CLR 将获得财政支持,以将这些见解融入其计划中,进一步提高其在预防青少年糖尿病和整体健康方面的有效性。讨论/意义:本研究可为体育参与、糖尿病风险因素和感知到的歧视之间的关系提供重要见解。研究结果可帮助 CLR 改进其计划,并通过其他青少年体育计划指导少数民族青少年采取更有效的糖尿病预防策略。
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引用次数: 0
487 Digital Spatial Profiling of Allograft Loss in Kidney Biopsies with Chronic Allograft Dysfunction 487 对慢性异体移植物功能障碍肾活检中的异体移植物损失进行数字空间分析
IF 2.6 Q3 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2024-04-03 DOI: 10.1017/cts.2024.413
Casey R. Dorr, Weihua Guan W, Guillaume Onyeaghala G, William S Oetting, Roslyn B Mannon, Gaurav Agarwal, Jonathan Maltzman, Arthur Matas, Pamala A Jacobson, Ajay K Israni, for DeKAF Genomics

OBJECTIVES/GOALS: Assess molecular and cellular mechanisms of allograft loss in kidney biopsies using digital spatial profiling and clinical outcomes data. METHODS/STUDY POPULATION: Patients with chronic allograft dysfunction (CGD), enrolled in the Deterioration of Kidney Allograft Function (DeKAF) study, with or without eventual allograft loss, were included. CGD was defined as a >25% increase in creatinine over 3 months relative to a baseline. Kidney biopsy tissue was assessed by Nanostring GeoMX digital spatial profiling (DSP) after staining with anti-pan-cytokeratin, anti-CD45, anti-CD68, Syto-13, to identify specific cell populations, and Nanostring’s Whole Transcriptome Atlas (WTA), to quantify the distribution of transcripts across the biopsy. Up to 14 regions of interest (ROIs) were selected, with or without glomerulus. CIBERSORT was used to perform cell deconvolution. Clinical and outcomes data were from the DeKAF study and United States Renal Data System. RESULTS/ANTICIPATED RESULTS: Macrophage (M1) cell population abundance was significantly different in ROIs with glomerulus between graft loss and no graft loss. Principle component analysis of differentially expressed genes resulted in transcriptomes in ROIs that cluster together by clinical outcome of graft loss or no graft loss. There were 203 DEGs in ROIs with glomerulus that were different by graft loss or no graft loss. By pathway analysis, these 203 DEGS were enriched in the T-cell activation, integrin signaling and inflammation pathways. DISCUSSION/SIGNIFICANCE: DSP of kidney allograft biopsies allows for the identification and quantification of specific cell types, such as macrophages and molecular transcripts as potential drug targets. This data can be used to understand mechanisms of kidney allograft loss and may lead to improved immune suppression in kidney transplant recipients.

目的/目标:利用数字空间图谱和临床结果数据评估肾活检中异体移植物损失的分子和细胞机制。方法/研究对象:纳入慢性同种异体移植功能障碍(CGD)患者,这些患者参加了肾脏同种异体移植功能恶化(DeKAF)研究,无论最终是否出现同种异体移植损失。CGD的定义是3个月内肌酐相对于基线上升25%。肾活检组织经抗泛角蛋白、抗CD45、抗CD68和Syto-13染色后,用Nanostring GeoMX数字空间图谱(DSP)进行评估,以确定特定的细胞群,并用Nanostring的全转录组图谱(WTA)量化活检组织中的转录本分布。在有或没有肾小球的情况下,最多可选择 14 个感兴趣区(ROI)。CIBERSORT用于进行细胞去卷积。临床和结果数据来自 DeKAF 研究和美国肾脏数据系统。结果/预期结果:在有肾小球的 ROI 中,巨噬细胞(M1)群的丰度在移植物丢失和无移植物丢失之间存在显著差异。对差异表达基因进行主成分分析后发现,ROI 中的转录组按照移植物缺失或无移植物缺失的临床结果聚类在一起。在有肾小球的 ROI 中,有 203 个 DEGs 因移植物缺失或无移植物缺失而不同。通过通路分析,这203个DEGS富集在T细胞活化、整合素信号转导和炎症通路中。讨论/意义:肾脏移植活组织的 DSP 可以识别和量化特定的细胞类型,如巨噬细胞和作为潜在药物靶点的分子转录本。这些数据可用于了解肾脏异体移植损失的机制,并可改善肾移植受者的免疫抑制。
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引用次数: 0
20 Characteristics of Medicare patients receiving peripheral vascular interventions for peripheral artery disease differ by outpatient site of service 20 因外周动脉疾病而接受外周血管介入治疗的医疗保险患者的特征因门诊服务地点而异
IF 2.6 Q3 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2024-04-03 DOI: 10.1017/cts.2024.39
Terrence Tsou, Chen Dun, Caitlin Hicks
OBJECTIVES/GOALS: Endovascular peripheral vascular interventions (PVIs) are increasingly utilized for the treatment of peripheral artery disease (PAD). We aimed to assess characteristics of patients receiving PVI at ambulatory surgical centers and office-based labs (ASC/OBL) versus the outpatient hospital (hospital) site of service. METHODS/STUDY POPULATION: We performed a retrospective analysis using 100% Medicare fee-for-service claims data between January 1, 2017 and December 31, 2022. We used Current Procedural Terminology (CPT) codes to identify patients undergoing angioplasty, stenting, or atherectomy. Patient demographics were collected from the Medicare Master Beneficiary Summary File and associated comorbidities and PVI indications were identified using International Classification of Disease (ICD)-10 codes. We used patient ZIP codes to determine patients’ residence densities and regions. We used site of service codes to determine whether PVI were performed in the ASC/OBL versus hospital. Results were analyzed with descriptive statistics. RESULTS/ANTICIPATED RESULTS: Of 817,241 patients undergoing PVI for PAD, 461,068 (56.4%) were treated in an ASC/OBL. Compared to patients treated in the hospital, patients receiving PVI at ASC/OBLs were more likely to be older, female, non-white race, with fewer comorbidities (end stage renal disease, diabetes, hypertension, and any history of tobacco use) (all, P<0.001). Patients treated in ASC/OBLs more frequently resided in urban (vs. rural) locations, and in the South and West (both, P<0.001). Indication for PVI was predominately chronic limb-threatening ischemia, and clinically similar between groups (77.1% vs. 76.2%). There was a significant change in site of service over time: a minority (47.6%) of PVIs were performed in the ASC/OBL in 2017, whereas the majority (64.7%) of PVIs were performed in the ASC/OBL in 2022 (P<0.001). DISCUSSION/SIGNIFICANCE: Patients treated in ASC/OBLs were less medically complex compared to those treated in the outpatient hospital setting. Further study is needed to examine whether differences in patient characteristics versus other factors (e.g. reimbursement) are driving the increase in PVIs performed in the ASC/OBL over time.
目的/目标:血管内外周血管介入治疗(PVI)越来越多地被用于治疗外周动脉疾病(PAD)。我们旨在评估在非卧床手术中心和办公室实验室(ASC/OBL)与门诊医院(医院)服务场所接受 PVI 患者的特征。方法/研究对象:我们使用 2017 年 1 月 1 日至 2022 年 12 月 31 日期间 100% 的医疗保险付费服务索赔数据进行了回顾性分析。我们使用当前程序术语(CPT)代码来识别接受血管成形术、支架植入术或动脉粥样硬化切除术的患者。患者的人口统计数据来自医疗保险主受益人摘要档案,相关合并症和 PVI 适应症则使用国际疾病分类 (ICD)-10 代码进行识别。我们使用患者的邮政编码来确定患者的居住密度和地区。我们使用服务地点代码来确定 PVI 是在 ASC/OBL 还是在医院进行的。结果采用描述性统计进行分析。结果/预期结果:在 817,241 名接受 PVI 治疗的 PAD 患者中,461,068 人(56.4%)在 ASC/OBL 接受了治疗。与在医院接受治疗的患者相比,在 ASC/OBLs 接受 PVI 治疗的患者更可能是老年人、女性、非白种人、合并症(终末期肾病、糖尿病、高血压和任何吸烟史)较少的患者(所有患者,P<0.001)。在 ASC/OBLs 接受治疗的患者更多居住在城市(相对于农村)、南部和西部(均为 P<0.001)。PVI的适应症主要是危及肢体缺血的慢性肢体缺血,各组之间的临床情况相似(77.1% vs. 76.2%)。随着时间的推移,服务地点发生了重大变化:2017年,少数(47.6%)PVI在ASC/OBL进行,而2022年,大多数(64.7%)PVI在ASC/OBL进行(P<0.001)。讨论/意义:与在医院门诊环境中接受治疗的患者相比,在ASC/OBLs接受治疗的患者医疗复杂程度较低。需要进一步研究患者特征与其他因素(如报销)之间的差异是否会导致在 ASC/OBL 进行的 PVI 随时间推移而增加。
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