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Pharmacotherapy guideline concordance for major depressive disorder and its link to functioning via symptom change. 重度抑郁障碍的药物治疗指南一致性及其通过症状变化与功能的联系。
IF 2.1 Q3 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2024-09-16 eCollection Date: 2024-01-01 DOI: 10.1017/cts.2024.562
Mason T Breitzig, Fan He, Lan Kong, Guodong Liu, Daniel A Waschbusch, Jeff D Yanosky, Duanping Liao, Erika F H Saunders

Introduction: Alleviation of symptom severity for major depressive disorder (MDD) is known to be associated with a lagged improvement of functioning. Pharmacotherapy guidelines support algorithms for MDD treatment. However, it is currently unclear whether concordance with guidelines influences functional recovery. A guideline concordance algorithm (GCA-8) was used to measure this pathway in a naturalistic clinical setting.

Methods: Data from 1403 adults (67% female, 84% non-Hispanic/Latino White, mean age of 43 years) with nonpsychotic MDD from the Penn State Psychiatry Clinical Assessment and Rating Evaluation System registry (visits from 02/01/2015 to 04/13/2021) were evaluated. Multivariable linear regression measured associations between GCA-8 and World Health Organization Disability Assessment Schedule 2.0 (WHODAS) scores. Mediation by MDD symptom severity using the Patient Health Questionnaire depression module (PHQ-9) was also evaluated.

Results: This study found a statistically significant improvement in WHODAS scores (functioning) between baseline and final measures (-2 points, P < .001) within one year. A one standard deviation increase in the GCA-8 score was associated with a 0.48-point reduction in mean disability score (total effect; P = .02) with significant mediation by the change in MDD symptom severity (coefficient = -0.51, P < .001) and a nonsignificant natural direct effect of the GCA-8 independent of PHQ-9 change (coefficient = -0.02, P = .92).

Conclusions: Higher pharmacotherapy guideline concordance is associated with better functioning for MDD patients; this association likely occurs through improvement in MDD symptom severity rather than directly.

简介众所周知,缓解重度抑郁障碍(MDD)的症状严重程度与功能改善的滞后性有关。药物治疗指南支持重度抑郁症的治疗算法。然而,目前还不清楚与指南的一致性是否会影响功能恢复。我们使用了指南一致性算法(GCA-8)来测量自然临床环境中的这一途径:评估了宾夕法尼亚州立精神病学临床评估和分级评价系统登记处的 1403 名非精神病性 MDD 成人(67% 为女性,84% 为非西班牙裔/拉美裔白人,平均年龄为 43 岁)的数据(就诊时间为 2015 年 1 月 2 日至 2021 年 3 月 4 日)。多变量线性回归测量了 GCA-8 和世界卫生组织残疾评估表 2.0 (WHODAS) 评分之间的关联。此外,还评估了患者健康问卷抑郁模块(PHQ-9)对 MDD 症状严重程度的调节作用:该研究发现,在一年内,基线与最终测量之间的 WHODAS 评分(功能)有了统计学意义上的显著改善(-2 分,P < .001)。GCA-8得分每增加一个标准差,平均残疾评分就会降低0.48分(总效应;P = .02),MDD症状严重程度的变化对其有明显的中介作用(系数 = -0.51,P < .001),GCA-8的自然直接效应与PHQ-9的变化无关(系数 = -0.02,P = .92):结论:药物治疗指南的一致性越高,MDD 患者的功能越好;这种关联可能是通过改善 MDD 症状的严重程度而非直接作用产生的。
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引用次数: 0
SEED: A novel web-based data visualization platform to visualize, communicate, and explore social, environmental, and equity drivers of health. SEED:一个新颖的网络数据可视化平台,用于可视化、交流和探索健康的社会、环境和公平驱动因素。
IF 2.1 Q3 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2024-09-16 eCollection Date: 2024-01-01 DOI: 10.1017/cts.2024.569
Nrupen A Bhavsar, Jessica Sperling, Raquel Ruiz, Dinushika Mohottige, Perusi Muhigaba, Mina Silberberg, Anthony Leiro, Pamela Maxson, Michelle Lyn, L Ebony Boulware

Multisector stakeholders, including, community-based organizations, health systems, researchers, policymakers, and commerce, increasingly seek to address health inequities that persist due to structural racism. They require accessible tools to visualize and quantify the prevalence of social drivers of health (SDOH) and correlate them with health to facilitate dialog and action. We developed and deployed a web-based data visualization platform to make health and SDOH data available to the community. We conducted interviews and focus groups among end users of the platform to establish needs and desired platform functionality. The platform displays curated SDOH and de-identified and aggregated local electronic health record data. The resulting Social, Environmental, and Equity Drivers (SEED) Health Atlas integrates SDOH data across multiple constructs, including socioeconomic status, environmental pollution, and built environment. Aggregated health prevalence data on multiple conditions can be visualized in interactive maps. Data can be visualized and downloaded without coding knowledge. Visualizations facilitate an understanding of community health priorities and local health inequities. SEED could facilitate future discussions on improving community health and health equity. SEED provides a promising tool that members of the community and researchers may use in their efforts to improve health equity.

多部门利益相关者,包括社区组织、卫生系统、研究人员、决策者和商业界,越来越多地寻求解决因结构性种族主义而持续存在的健康不平等问题。他们需要便于使用的工具来可视化和量化影响健康的社会因素(SDOH),并将其与健康联系起来,以促进对话和行动。我们开发并部署了一个基于网络的数据可视化平台,向社区提供健康和 SDOH 数据。我们对平台的最终用户进行了访谈和焦点小组讨论,以确定需求和所需的平台功能。该平台可显示经整理的 SDOH 数据以及去标识化和汇总的本地电子健康记录数据。由此产生的社会、环境和公平驱动因素(SEED)健康地图集整合了多个方面的 SDOH 数据,包括社会经济状况、环境污染和建筑环境。有关多种情况的汇总健康流行率数据可在交互式地图中直观显示。无需编码知识即可直观显示和下载数据。可视化有助于了解社区健康优先事项和当地的健康不公平现象。SEED 可促进未来有关改善社区健康和健康公平的讨论。SEED 提供了一个很有前途的工具,社区成员和研究人员可以利用它来改善健康公平状况。
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引用次数: 0
Supporting students from underrepresented minority backgrounds in graduate school: A mixed-methods formative study to inform post-baccalaureate design. 为研究生院中少数族裔背景学生提供支持:一项混合方法形成性研究,为学士后教育设计提供信息。
IF 2.1 Q3 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2024-09-16 eCollection Date: 2024-01-01 DOI: 10.1017/cts.2024.590
Jessica B Sperling, Noelle E Wyman Roth, Whitney E Welsh, Allison T McElvaine, Sallie R Permar, Rasheed A Gbadegesin

The US biomedical research workforce suffers from systemic barriers causing insufficient diversity and perpetuating inequity. To inform programming enhancing graduate program access, we implemented a formative mixed-method study to identify needed supports for program applications and graduate program success. Overall, results indicate value in added supports for understanding application needs, network development, critical thinking, time management, and reading academic/scientific literature. We find selected differences for underrepresented minority (URM) students compared to others, including in the value of psychosocial supports. This work can inform broader efforts to enhance graduate school access and provides foundation for further understanding of URM students' experiences.

美国的生物医学研究人员队伍存在着系统性障碍,导致多样性不足和不公平现象长期存在。为了给提高研究生项目准入的计划提供信息,我们实施了一项形成性混合方法研究,以确定项目申请和研究生项目成功所需的支持。总体而言,研究结果表明,在了解申请需求、网络发展、批判性思维、时间管理和阅读学术/科学文献等方面增加支持是有价值的。我们发现,与其他学生相比,代表性不足的少数民族(URM)学生在社会心理支持的价值等方面存在一定的差异。这项工作可以为提高研究生入学率提供更广泛的信息,并为进一步了解少数民族学生的经历奠定基础。
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引用次数: 0
Factors associated with clinician willingness to adopt HPV self-sampling and self-testing for cervical cancer screening. 临床医生在宫颈癌筛查中采用 HPV 自我采样和自我检测意愿的相关因素。
IF 2.1 Q3 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2024-09-16 eCollection Date: 2024-01-01 DOI: 10.1017/cts.2024.604
Luke Brennan, Tiwaladeoluwa Adekunle, Monica Kasting, Michele R Forman, Victoria Champion, Natalia M Rodriguez

Background: Cervical cancer screening rates in the USA fall behind national targets, requiring innovation to circumvent screening barriers. Cervical cancer screening where human papillomavirus (HPV) testing is performed on vaginal samples collected by the patients themselves (self-sampling) are effective and acceptable, and patient-operated rapid HPV tests (self-testing) are currently under development. It is unclear why there is ambivalence toward HPV self-sampling and self-testing among clinicians, an important stakeholder group. We conducted a mixed convergent quantitative and qualitative study to identify the factors influencing clinicians' attitudes toward self-sampling and self-testing.

Methods: A survey of Midwest clinicians distributed by professional group media and a market research firm between May and November 2021 was analyzed (n = 248) alongside in-depth interviews with Midwest clinicians from professional groups (n = 23). Logistic regression models examined willingness to support self-sampling and self-testing across respondent characteristics.

Results: We report that family practice physicians and those in rural areas were more willing to adopt HPV self-sampling (adjusted OR (aOR) = 3.16 [1.43-6.99]; aOR = 2.17 [1.01-4.68]). Clinician willingness to support self-testing was positively associated with current use of self-testing for other conditions and negatively associated with performing 10 or more monthly cervical cancer screenings (aOR = 2.02 [1.03-3.95], aOR = 0.42 [0.23-0.78]). Qualitative data contextualize how clinical specialty and experience with self-sampling and self-testing for other conditions inform clinician perspectives.

Conclusion: These data suggest clinician populations most accepting of initiatives to implement self-sampling and self-testing for cervical cancer screening and highlight that experience with other forms of self-testing could facilitate more widespread adoption for cervical cancer.

背景:美国的宫颈癌筛查率落后于国家目标,需要创新来规避筛查障碍。通过患者自己采集的阴道样本进行人类乳头瘤病毒(HPV)检测(自我采样)的宫颈癌筛查既有效又可接受,目前正在开发由患者操作的快速 HPV 检测(自我检测)。目前尚不清楚临床医生这一重要的利益相关群体为何对 HPV 自采样和自检测持矛盾态度。我们开展了一项定量和定性混合研究,以确定影响临床医生对自我采样和自我检测态度的因素:我们分析了 2021 年 5 月至 11 月期间由专业团体媒体和市场研究公司分发的中西部临床医生调查问卷(n = 248),以及对专业团体中西部临床医生的深度访谈(n = 23)。逻辑回归模型考察了不同受访者特征下支持自我采样和自我检测的意愿:结果:我们发现家庭医生和农村地区的医生更愿意采用 HPV 自我采样(调整后 OR (aOR) = 3.16 [1.43-6.99]; aOR = 2.17 [1.01-4.68])。临床医生支持自我检测的意愿与目前使用自我检测治疗其他疾病呈正相关,而与每月进行 10 次或更多次宫颈癌筛查呈负相关(aOR = 2.02 [1.03-3.95]; aOR = 0.42 [0.23-0.78])。定性数据说明了临床专业以及自我采样和自我检测其他疾病的经验如何影响临床医生的观点:这些数据表明,临床医生群体最能接受在宫颈癌筛查中实施自我采样和自我检测的举措,并强调其他形式的自我检测经验可促进宫颈癌筛查的更广泛采用。
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引用次数: 0
Developing decision support tools for high-risk women and healthcare providers to increase chemoprevention informed choice and uptake: A retrospective translational science case study 为高危妇女和医疗服务提供者开发决策支持工具,以增加化学预防的知情选择和吸收:回顾性转化科学案例研究
IF 2.6 Q3 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2024-09-10 DOI: 10.1017/cts.2024.565
Leah G. Pope, Zainab Abedin, Katherine D. Crew, Rita Kukafka, Harold Alan Pincus
Retrospective case studies are one approach to help identify processes underlying the translation of successful health interventions. This case study investigates the development of RealRisks and Breast Cancer Risk Navigation (BNAV), decision support tools for breast cancer risk assessment, and risk-stratified prevention. Following a recently developed protocol for retrospective translational science case studies, we examined the career trajectory of Dr Katherine Crew as she expanded from basic science to interdisciplinary, patient-oriented research in oncology and began collaboration with Dr Rita Kukafka, a public health informatician focused on communicating risk. Data collection methods included key informant interviews and examination of peer-reviewed publications, funded grants, and news articles associated with the research. Data were analyzed to identify key milestones in the development of RealRisks and BNAV and to elucidate facilitators and barriers to the translational process. Facilitators to translation included funding and infrastructure provided by a Clinical and Translational Science Award (CTSA), the creation of an interdisciplinary team, and broad support from stakeholders including patient advocacy groups. Barriers to translation included limited mid-career support, ongoing costs for technology, and the time required to establish interdisciplinary, team science efforts. The findings reported here can be used to inform ongoing efforts to develop a more robust science of translation.
回顾性案例研究是帮助确定成功的健康干预措施转化过程的一种方法。本案例研究调查了RealRisks和乳腺癌风险导航(BNAV)的开发过程,这是用于乳腺癌风险评估和风险分层预防的决策支持工具。按照最近制定的转化科学案例回顾性研究协议,我们考察了凯瑟琳-克鲁博士的职业轨迹,她从基础科学扩展到肿瘤学领域以患者为导向的跨学科研究,并开始与专注于风险交流的公共卫生信息学家丽塔-库卡夫卡(Rita Kukafka)博士合作。数据收集方法包括关键信息提供者访谈,以及对同行评议出版物、资助基金和与研究相关的新闻报道的审查。通过对数据进行分析,确定了 RealRisks 和 BNAV 开发过程中的关键里程碑,并阐明了转化过程中的促进因素和障碍。促进转化的因素包括临床和转化科学奖(CTSA)提供的资金和基础设施、跨学科团队的建立以及包括患者权益团体在内的利益相关者的广泛支持。转化的障碍包括有限的中期支持、技术的持续成本以及建立跨学科团队科学工作所需的时间。本文报告的研究结果可用于为正在进行的开发更强大的转化科学的工作提供信息。
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引用次数: 0
The adolescent health network: A unique approach to sustained adolescent stakeholder engagement 青少年健康网络:青少年利益攸关方持续参与的独特方法
IF 2.6 Q3 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2024-09-10 DOI: 10.1017/cts.2024.567
Deepa L. Sekhar, Alicia M. Hoke, Marwa Khan, Patricia L. Gordon, Erin K. Conahan, Jennifer L. Kraschnewski
At least 70% of premature adult deaths result from behaviors starting and reinforced in adolescence. The use of adolescent-centered outcomes and the necessity of creating space for the adolescent voice regarding research that directly impacts them is often overlooked. These omissions result in proposals and solutions that lack consideration of adolescent ingenuity, preferences, and needs. In 2021, Penn State PRO Wellness was awarded a Patient-Centered Outcomes Research Institute Engagement Award with the goal of addressing the gap in the inclusion of adolescents in research focused on teenage health. The resultant Adolescent Health Network (AHN) was developed in partnership with a stakeholder advisory board comprised of adolescents, parents, health researchers, and school staff. The AHN currently consists of 12 schools and 43 adolescents who have completed stakeholder training. For adolescents, the AHN simulates a school club or career enrichment activity with incoming freshmen replacing graduating seniors over time. For health researchers, the AHN provides rapid, easy access to a pool of adolescents with stakeholder training who are available to provide input on various aspects of a study from recruitment plans, to survey tools to dissemination strategies. This manuscript details the development, execution, and data from this novel program.
至少有 70% 的成年人过早死亡是由青少年时期开始并强化的行为造成的。在对青少年有直接影响的研究中,以青少年为中心的结果的使用以及为青少年创造发言空间的必要性常常被忽视。这些疏忽导致提出的建议和解决方案缺乏对青少年独创性、偏好和需求的考虑。2021 年,宾夕法尼亚州立大学 PRO Wellness 获得了 "以患者为中心的结果研究机构参与奖",其目标是解决青少年参与青少年健康研究方面的不足。由此产生的青少年健康网络(AHN)是与由青少年、家长、健康研究人员和学校教职员工组成的利益相关者咨询委员会合作开发的。AHN 目前由 12 所学校和 43 名青少年组成,他们都已完成了利益相关者培训。对于青少年而言,"青少年健康网 "模拟学校俱乐部或职业充实活动,让新生在一段时间内取代即将毕业的高年级学生。对于健康研究人员来说,AHN 可以让他们快速、方便地接触到受过利益相关者培训的青少年,这些青少年可以就研究的各个方面(从招募计划、调查工具到传播策略)提供意见。本手稿详细介绍了这一新颖项目的开发、执行和数据。
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引用次数: 0
Development of TRACER: A Translational Research Accomplishments Cataloguer for Clinical and Translational Science Award hub activity tracking, evaluation, and decision-making 开发 TRACER:用于临床和转化科学奖中枢活动跟踪、评估和决策的转化研究成果编目器
IF 2.6 Q3 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2024-09-06 DOI: 10.1017/cts.2024.545
Jessica Sperling, Stella Quenstedt, Anthony Leiro, Perusi B. Muhigaba, F. Joseph McClernon
Organizations supporting translational research and translational science, including Clinical and Translational Science Award (CTSA) hubs, provide a diverse and often changing array of resources, support, and services to a myriad of researchers and research efforts. While a wide-ranging scope of programs is essential to the advancement of translational research and science, it also complicates a systematic and unified process for tracking activities, studying research processes, and examining impact. To overcome these challenges, the Duke University School of Medicine’s CTSA hub created a data platform, Translational Research Accomplishment Cataloguer (TRACER), that provides capacity to enhance strategic decision-making, impact assessment, and equitable resource distribution. This article reviews TRACER development processes, provides an overview of the TRACER platform, addresses challenges in the development process, and describes avenues for addressing or overcoming these challenges. TRACER development allowed our hub to conceptually identify key processes and goals within programs and linkages between programs, and it sets the stage for advancing evidence-based improvement across our hub. This platform development provides key insight into facilitators that can inform other initiatives seeking to collect and align organizational data for strategic decision-making and impact assessment. TRACER or similar platforms are additionally well positioned to advance the study of translational science.
支持转化研究和转化科学的组织,包括临床与转化科学奖(CTSA)中心,为无数研究人员和研究工作提供了多种多样且经常变化的资源、支持和服务。虽然范围广泛的计划对促进转化研究和科学发展至关重要,但它也使追踪活动、研究过程和检查影响的系统化统一流程变得更加复杂。为了克服这些挑战,杜克大学医学院的 CTSA 中心创建了一个数据平台--转化研究成就目录(TRACER),为加强战略决策、影响评估和公平资源分配提供了能力。本文回顾了 TRACER 的开发过程,概述了 TRACER 平台,探讨了开发过程中的挑战,并介绍了应对或克服这些挑战的途径。TRACER 的开发使我们的中心能够从概念上确定计划内的关键流程和目标以及计划之间的联系,并为在整个中心推进循证改进奠定了基础。该平台的开发提供了对促进因素的重要见解,可为其他寻求收集和调整组织数据以进行战略决策和影响评估的倡议提供参考。此外,TRACER 或类似平台还能很好地推动转化科学研究。
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引用次数: 0
Connecting with the community: Perceptions of a community tour 与社区建立联系:对社区游的看法
IF 2.6 Q3 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2024-09-06 DOI: 10.1017/cts.2024.588
Christopher Jones, Kandice Reilly, Brian Peacock, Nancy Denizard-Thompson, Alicia Walters-Stewart, Leslie Doroski McDowell, Jessica Valente, Aylin A. Aguilar, Michael Lischke, Kimberly Montez
Introduction: This study explores the transformative effects of the Community Plunge, an educational program at the Wake Forest University School of Medicine (WFUSOM), on healthcare delivery, community engagement, and trainee perspectives. It addresses the broader context of health outcomes, where clinical care only accounts for 20%, emphasizing the critical role of social determinants of health (SDOH) and individual behaviors in the remaining 80%. Methods: WFUSOM’s Community Plunge, established in 2002, involves a guided tour of the community, discussions with residents, and debriefing sessions. Qualitative interviews with 20 clinicians were conducted to extract key themes and insights. Results: The study identified several key outcomes. First, participants gained crucial insights into the community’s history, structural challenges, and prevalent SDOH, enhancing their understanding of the diverse patient populations they serve. Second, the program positively influenced clinician attitudes, fostering empathy, reducing paternalism, and promoting holistic patient care. Third, participants expressed a desire for increased community involvement and reported career trajectory changes toward advocacy and volunteerism. However, challenges such as time constraints were acknowledged. Conclusions: The study advocates for collaborative efforts to enhance the program’s impact, including proactive measures to ensure respectful engagement during community tours. It positions the Community Plunge as an innovative, scalable, and transformative strategy for experiential SDOH exposure, crucial for the evolving social consciousness of healthcare learners.
简介:本研究探讨了维克森林大学医学院(Wake Forest University School of Medicine,WFUSOM)的一项教育计划--"社区暴跌"(Community Plunge)对医疗服务、社区参与和受训者观点的变革性影响。该项目涉及更广泛的健康结果,其中临床护理只占 20%,强调健康的社会决定因素 (SDOH) 和个人行为在其余 80% 中的关键作用。方法:WFUSOM 的 "社区暴跌 "活动始于 2002 年,包括社区导览、与居民讨论和汇报会。对 20 名临床医生进行了定性访谈,以提取关键主题和见解。结果研究确定了几项关键成果。首先,参与者对社区的历史、结构性挑战和普遍存在的 SDOH 有了重要的了解,从而增强了他们对所服务的不同患者群体的理解。其次,该计划对临床医生的态度产生了积极影响,培养了同理心,减少了家长式作风,促进了对患者的全面护理。第三,参与者表达了更多参与社区活动的愿望,并报告了向宣传和志愿服务方向发展的职业轨迹变化。不过,他们也承认存在时间限制等挑战。结论:本研究提倡通过合作努力来提高计划的影响力,包括采取积极措施,确保在社区参观过程中尊重参与者。它将 "社区暴跌 "定位为一种创新的、可扩展的和变革性的策略,用于体验性地接触 SDOH,这对医疗保健学习者不断发展的社会意识至关重要。
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引用次数: 0
The role of the adenylate kinase 5 gene in various diseases and cancer 腺苷酸激酶 5 基因在各种疾病和癌症中的作用
IF 2.6 Q3 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2024-08-19 DOI: 10.1017/cts.2024.536
M. Sarim Siddiqui, Mehdi H. Shahi, Javier S. Castresana
Adenylate kinases (AKs) are important enzymes involved in cellular energy metabolism. Among AKs, AK5 (adenylate kinase 5), a cytosolic protein, is emerging as a significant contributor to various diseases and cellular processes. This comprehensive review integrates findings from various research groups on AK5 since its discovery, shedding light on its multifaceted roles in nucleotide metabolism, energy regulation, and cellular differentiation. We investigate its implications in a spectrum of diseases, including autoimmune encephalitis, epilepsy, neurodegenerative disorders such as Alzheimer’s and Parkinson’s, diabetes, lower extremity arterial disease, celiac disease, and various cancers. Notably, AK5’s expression levels and methylation status have been associated with cancer progression and patient outcomes, indicating its potential as a prognostic indicator. Furthermore, AK5 is implicated in regulating cellular processes in breast cancer, gastric cancer, colorectal carcinoma, prostate cancer, and colon adenocarcinoma, suggesting its relevance across different cancer types. However, a limitation lies in the need for more robust clinical validation and a deeper understanding of AK5’s precise mechanisms in disease pathogenesis, despite its association with various pathophysiological conditions. Nonetheless, AK5 holds promise as a therapeutic target, with emerging evidence suggesting its potential in therapy development.
腺苷酸激酶(AKs)是参与细胞能量代谢的重要酶类。在腺苷酸激酶中,AK5(腺苷酸激酶 5)是一种细胞膜蛋白,正逐渐成为导致各种疾病和细胞过程的重要因素。本综述综合了自 AK5 被发现以来各研究小组的研究成果,揭示了它在核苷酸代谢、能量调节和细胞分化中的多方面作用。我们研究了它在一系列疾病中的影响,包括自身免疫性脑炎、癫痫、神经退行性疾病(如阿尔茨海默氏症和帕金森氏症)、糖尿病、下肢动脉疾病、乳糜泻和各种癌症。值得注意的是,AK5 的表达水平和甲基化状态与癌症进展和患者预后有关,这表明它有可能成为预后指标。此外,AK5 还与乳腺癌、胃癌、结直肠癌、前列腺癌和结肠腺癌的细胞过程调控有关,这表明它与不同癌症类型都有关联。然而,尽管 AK5 与各种病理生理状况有关,但其局限性在于需要更有力的临床验证,以及更深入地了解 AK5 在疾病发病机制中的确切机制。尽管如此,AK5 仍有希望成为一个治疗靶点,新出现的证据表明它在治疗开发中具有潜力。
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引用次数: 0
Health Equity Engineering: Optimizing Hope for a New Generation of Healthcare 健康公平工程:优化新一代医疗保健的希望
IF 2.6 Q3 Medicine Pub Date : 2024-05-23 DOI: 10.1017/cts.2024.549
Felicity T Enders, Elizabeth H Golembiewski, Joyce E. Balls-Berry, Tayla R. Brooks, Allison R. Carr, John P. Cullen, Deborah DiazGranados, Ayorkor Gaba, Leigh Johnson, Terri Menser, Shari Messinger, Adam J. Milam, Minerva A. Orellana, Susan M. Perkins, Tiffany D. Chisholm Pineda, Sally W. Thurston, V. Periyakoil, Alexandra L. Hanlon
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引用次数: 0
期刊
Journal of Clinical and Translational Science
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