Cette brève réflexion relative à l’évolution de la pandémie du COVID-19 dans le monde vise à montrer qu’outre l’important déséquilibre qui existe entre le Nord et le Sud de la planète dans l’accès aux soins et à la vaccination, est de surcroît compliqué par des croyances religieuses et culturelles qui hypothèquent une prise en charge efficiente de la pandémie. L’exemple algérien ici évoqué est de ce point de vue édifiant.
{"title":"L’afrique à L’épreuve de la Pandémie de la Covid-19 Point de Vue Socio-Culturel","authors":"","doi":"10.33140/jodh.05.03.01","DOIUrl":"https://doi.org/10.33140/jodh.05.03.01","url":null,"abstract":"Cette brève réflexion relative à l’évolution de la pandémie du COVID-19 dans le monde vise à montrer qu’outre l’important déséquilibre qui existe entre le Nord et le Sud de la planète dans l’accès aux soins et à la vaccination, est de surcroît compliqué par des croyances religieuses et culturelles qui hypothèquent une prise en charge efficiente de la pandémie. L’exemple algérien ici évoqué est de ce point de vue édifiant.","PeriodicalId":15598,"journal":{"name":"Journal of dental health, oral disorders & therapy","volume":"28 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87222336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
This study was carried out to evaluate the load distribution along the two feet in subjects with rotated mandibles. This study used the Staticus device from Smylist® to map the foot pressure loads after the three jump test. Data was obtained from 20 subjects. The Staticus data was acquired by the Smylist® analytic software and the load distribution patterns were obtained. Subjects were selected so as to have at least 75% of them exhibiting an asymmetrical vertically displaced pattern. The Smylist® concept has presented a logical sequence of events which leads from a rotated mandible to overloading of one leg based on the complexity of the mandibular rotation. This is the first study ever to digitally ascertain the variation in the load patterns. It was found that in the subjects who exhibited a vertical foot position discrepancy also had a discrepancy in the load patterns and mandibular rotations.
{"title":"Feet Load Distribution in Subjects with Mandibular Rotations","authors":"","doi":"10.33140/jodh.05.03.02","DOIUrl":"https://doi.org/10.33140/jodh.05.03.02","url":null,"abstract":"This study was carried out to evaluate the load distribution along the two feet in subjects with rotated mandibles. This study used the Staticus device from Smylist® to map the foot pressure loads after the three jump test. Data was obtained from 20 subjects. The Staticus data was acquired by the Smylist® analytic software and the load distribution patterns were obtained. Subjects were selected so as to have at least 75% of them exhibiting an asymmetrical vertically displaced pattern. The Smylist® concept has presented a logical sequence of events which leads from a rotated mandible to overloading of one leg based on the complexity of the mandibular rotation. This is the first study ever to digitally ascertain the variation in the load patterns. It was found that in the subjects who exhibited a vertical foot position discrepancy also had a discrepancy in the load patterns and mandibular rotations.","PeriodicalId":15598,"journal":{"name":"Journal of dental health, oral disorders & therapy","volume":"80 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74958974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: Ranulas are defined as the extravasation of mucus into an intraoral cystic cavity produced by an injury to the excretory ducts or the acini of the sublingual gland. Plunging ranulas are generated when the salivary collection penetrates the mylohyoid through a dehiscence of its fibers, invading the submandibular space. The close relationship between these lesions and HIV-AIDS infection has been reported since 2004, with a 75.88% rate of positive cases. The objective of this article is to present the management of patient with a plunging ranula, which made it possible to address the diagnosis of HIV-AIDS. Case Report: A 28-year-old male patient presented with a painless and fluctuating swelling in the laterocervical space and the floor of the mouth, which produced dysphagia and dyslalia. Serological tests for HIV were carried out and had a reactive result. Surgical treatment was performed via intraoral approach, with a favorable evolution at 12 months of follow-up. Conclusion: Ranulas, and particularly plunging ranulas, should be considered in the group of oral lesions associated with HIVAIDS infection, as they may even be the initial manifestation of the disease.
{"title":"Plunging Ranula as Initial Manifestation of HIV-AIDS: A Case Report and Literature Review","authors":"","doi":"10.33140/jodh.05.03.03","DOIUrl":"https://doi.org/10.33140/jodh.05.03.03","url":null,"abstract":"Introduction: Ranulas are defined as the extravasation of mucus into an intraoral cystic cavity produced by an injury to the excretory ducts or the acini of the sublingual gland. Plunging ranulas are generated when the salivary collection penetrates the mylohyoid through a dehiscence of its fibers, invading the submandibular space. The close relationship between these lesions and HIV-AIDS infection has been reported since 2004, with a 75.88% rate of positive cases. The objective of this article is to present the management of patient with a plunging ranula, which made it possible to address the diagnosis of HIV-AIDS. Case Report: A 28-year-old male patient presented with a painless and fluctuating swelling in the laterocervical space and the floor of the mouth, which produced dysphagia and dyslalia. Serological tests for HIV were carried out and had a reactive result. Surgical treatment was performed via intraoral approach, with a favorable evolution at 12 months of follow-up. Conclusion: Ranulas, and particularly plunging ranulas, should be considered in the group of oral lesions associated with HIVAIDS infection, as they may even be the initial manifestation of the disease.","PeriodicalId":15598,"journal":{"name":"Journal of dental health, oral disorders & therapy","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76051131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-06-30DOI: 10.15406/jdhodt.2021.12.00549
Francisca Durán, Francisca Hormazábal
In dentistry, temporomandibular joint (TMJ) ankylosis is a rare pathology where no consensus of global population data has been found and therefore has presented a challenge for professionals, since there are no treatment sequence protocols standardized. The objective is to carry out a literature review and update of the diagnosis of ankylosis, considering its clinical characteristics, classification, etiology, and epidemiology. Giving special emphasis to the types of treatments used and concluding that GAP interpositional arthroplasty and TMJ reconstruction arthroplasty would be the best options to improve maximum oral opening in a patient with ankylosis, thus allowing him to recover function and aesthetics.
{"title":"Ankylosis of the Temporomandibular Joint (TMJ) Update and its treatment","authors":"Francisca Durán, Francisca Hormazábal","doi":"10.15406/jdhodt.2021.12.00549","DOIUrl":"https://doi.org/10.15406/jdhodt.2021.12.00549","url":null,"abstract":"In dentistry, temporomandibular joint (TMJ) ankylosis is a rare pathology where no consensus of global population data has been found and therefore has presented a challenge for professionals, since there are no treatment sequence protocols standardized. The objective is to carry out a literature review and update of the diagnosis of ankylosis, considering its clinical characteristics, classification, etiology, and epidemiology. Giving special emphasis to the types of treatments used and concluding that GAP interpositional arthroplasty and TMJ reconstruction arthroplasty would be the best options to improve maximum oral opening in a patient with ankylosis, thus allowing him to recover function and aesthetics.","PeriodicalId":15598,"journal":{"name":"Journal of dental health, oral disorders & therapy","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82133828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-03-14DOI: 10.15406/jdhodt.2021.12.00548
Haifa Barakah
Discrepancy between a large jaw size and small teeth results in a spaced alignment of teeth. Orthodontic treatment to correct such cases will not be sufficient for esthetic results of anterior teeth. Restorative treatment may be the ideal solution to reshape small teeth in well planned proportion to fit the size of the jaw and enhance the appearance of the patient smile. This paper presents the process of restoring spaced anterior teeth with minimally prepared ceramic veneers using the RED proportion.
{"title":"Esthetic ceramic veneers for spaced anterior teeth utilizing the RED proportion; a case report with three years follow-up","authors":"Haifa Barakah","doi":"10.15406/jdhodt.2021.12.00548","DOIUrl":"https://doi.org/10.15406/jdhodt.2021.12.00548","url":null,"abstract":"Discrepancy between a large jaw size and small teeth results in a spaced alignment of teeth. Orthodontic treatment to correct such cases will not be sufficient for esthetic results of anterior teeth. Restorative treatment may be the ideal solution to reshape small teeth in well planned proportion to fit the size of the jaw and enhance the appearance of the patient smile. This paper presents the process of restoring spaced anterior teeth with minimally prepared ceramic veneers using the RED proportion.","PeriodicalId":15598,"journal":{"name":"Journal of dental health, oral disorders & therapy","volume":"524 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77102666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-03-11DOI: 10.15406/jdhodt.2021.12.00544
D. Hadyaoui, Yosra Farhat, Imen Kalghoum, Yosra Gasara, Z. Nouira, B. Harzallah, M. Chérif
Since trauma is a common incident that adolescents are faced with, the post-traumatic therapeutic solution presents a challenge for the clinicians .This case report demonstrates how a young patient with minimal extended fracture of incisor was rehabilitated with non-invasive adhesive restoration known as partial veneer or chip with Feld spathic porcelain. Those restorations fit into the anatomy and shape of the teeth perfectly and restore only the fractured part which integrates in tissue economy dynamic. Feldspathic porcelain is the material that best reproduces the characteristics of enamel, in terms of surface properties, modulus of elasticity, resistance to fracture and the reproduction of the optical properties of the dental structure, especially at minimal thickness. In this paper we describe the details of the treatment and the final result which was aesthetic and surpass the patient’s expectation.
{"title":"Restoring a fractured incisor of a teenager with partial veneer","authors":"D. Hadyaoui, Yosra Farhat, Imen Kalghoum, Yosra Gasara, Z. Nouira, B. Harzallah, M. Chérif","doi":"10.15406/jdhodt.2021.12.00544","DOIUrl":"https://doi.org/10.15406/jdhodt.2021.12.00544","url":null,"abstract":"Since trauma is a common incident that adolescents are faced with, the post-traumatic therapeutic solution presents a challenge for the clinicians .This case report demonstrates how a young patient with minimal extended fracture of incisor was rehabilitated with non-invasive adhesive restoration known as partial veneer or chip with Feld spathic porcelain. Those restorations fit into the anatomy and shape of the teeth perfectly and restore only the fractured part which integrates in tissue economy dynamic. Feldspathic porcelain is the material that best reproduces the characteristics of enamel, in terms of surface properties, modulus of elasticity, resistance to fracture and the reproduction of the optical properties of the dental structure, especially at minimal thickness. In this paper we describe the details of the treatment and the final result which was aesthetic and surpass the patient’s expectation.","PeriodicalId":15598,"journal":{"name":"Journal of dental health, oral disorders & therapy","volume":"73 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86372795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-03-11DOI: 10.15406/jdhodt.2021.12.00545
Pedro Luiz de Carvalho, Monica Naomi Seko, Erick Alves dos Santos, Larissa Victória Barbosa Freitas, Edson Marcos Leal Soares Ramos, Afonso Celso Souza de Assis, Kunihiro Saito, João Marcelo Ferreira de Medeiros
Objective: To determine the prevalence of knowledge about cone-beam computed tomography (CBCT) by endodontists from the Metropolitan Area of Belém, Pará, Brazil. Material and methods: 151 questionnaires were spread containing 32 questions, 15 closed questions, 4 open and 13 mixed. Questions 1 to17 dealt with questions such as age; gender; geographic location where endodontists' office operates; year of graduation degree and of specialization in endodontics; owned equipment and questions about the conventional radiology practice at dental office. Questions 18 to 32 were related to knowledge about the CBCT and only those who reported having knowledge answered the questions 19 onwards. Results: 81 questionnaires were analyzed. 48 endodontists (59%) had some knowledge about CBCT, but among them, 5 never requested until that occasion. Regarding the radiation level, 76.75% have not any information about. The treatment plan of 36 (83.72%) those who requested CBCT changed. Conclusion: The CBCT imaging is slowly becoming an essential modality of imaging in the clinical practice of endodontists from the Metropolitan Area of Belém, Para, Brazil.
{"title":"Knowledge and ability assessment of endodontists to prescribe and analyze cone beam computed tomography","authors":"Pedro Luiz de Carvalho, Monica Naomi Seko, Erick Alves dos Santos, Larissa Victória Barbosa Freitas, Edson Marcos Leal Soares Ramos, Afonso Celso Souza de Assis, Kunihiro Saito, João Marcelo Ferreira de Medeiros","doi":"10.15406/jdhodt.2021.12.00545","DOIUrl":"https://doi.org/10.15406/jdhodt.2021.12.00545","url":null,"abstract":"Objective: To determine the prevalence of knowledge about cone-beam computed tomography (CBCT) by endodontists from the Metropolitan Area of Belém, Pará, Brazil. Material and methods: 151 questionnaires were spread containing 32 questions, 15 closed questions, 4 open and 13 mixed. Questions 1 to17 dealt with questions such as age; gender; geographic location where endodontists' office operates; year of graduation degree and of specialization in endodontics; owned equipment and questions about the conventional radiology practice at dental office. Questions 18 to 32 were related to knowledge about the CBCT and only those who reported having knowledge answered the questions 19 onwards. Results: 81 questionnaires were analyzed. 48 endodontists (59%) had some knowledge about CBCT, but among them, 5 never requested until that occasion. Regarding the radiation level, 76.75% have not any information about. The treatment plan of 36 (83.72%) those who requested CBCT changed. Conclusion: The CBCT imaging is slowly becoming an essential modality of imaging in the clinical practice of endodontists from the Metropolitan Area of Belém, Para, Brazil.","PeriodicalId":15598,"journal":{"name":"Journal of dental health, oral disorders & therapy","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83736037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-12DOI: 10.15406/jdhodt.2021.12.00543
Prabhleen Kaur Brar, R. Brar, Saurabh K. Gupta, Ramandeep Singh Gambhir
Background: Variations in the external morphologic features of the teeth occur in individuals and so does the internal morphology of the crown and the root. Mandibular anteriors are known to have aberrant canals. Based on the possible branching of the root canal system, root canal configurations of permanent teeth were divided into eight different types by Vertucci. Aim: This paper presents a rare case of successful endodontic treatment of mandibular lateral incisors with Vertucci type III canal morphology. Methods: Conventional root canal treatment was done for the mandibular anterior teeth. Results: The treatment was successful and the patient was asymptomatic on follow up, suggesting that conventional methods for root canal treatment are sufficient if proper diagnosis of canal anatomy is done. Conclusion: This case report highlights the importance of adequate pre-operative radiograph evaluation to treat any mandibular anterior tooth with variable anatomy.
{"title":"Mandibular lateral incisors with vertucci type III root canal configuration- a case report","authors":"Prabhleen Kaur Brar, R. Brar, Saurabh K. Gupta, Ramandeep Singh Gambhir","doi":"10.15406/jdhodt.2021.12.00543","DOIUrl":"https://doi.org/10.15406/jdhodt.2021.12.00543","url":null,"abstract":"Background: Variations in the external morphologic features of the teeth occur in individuals and so does the internal morphology of the crown and the root. Mandibular anteriors are known to have aberrant canals. Based on the possible branching of the root canal system, root canal configurations of permanent teeth were divided into eight different types by Vertucci. Aim: This paper presents a rare case of successful endodontic treatment of mandibular lateral incisors with Vertucci type III canal morphology. Methods: Conventional root canal treatment was done for the mandibular anterior teeth. Results: The treatment was successful and the patient was asymptomatic on follow up, suggesting that conventional methods for root canal treatment are sufficient if proper diagnosis of canal anatomy is done. Conclusion: This case report highlights the importance of adequate pre-operative radiograph evaluation to treat any mandibular anterior tooth with variable anatomy.","PeriodicalId":15598,"journal":{"name":"Journal of dental health, oral disorders & therapy","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81624038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-12DOI: 10.15406/jdhodt.2021.12.00542
Jachmen Sultana, Quazi Billur Rahman, E. Chowdhury, Nasrin Sultana Juyena, Abul Bashar
Background: Costochondral graft has been used as a substitute for a growth center in the damaged Temporomandibular joint (TMJ) in the growing children. But the relapse of the TMJ ankylosis along with facial deformity is the most common outcome after the surgery for the resorption or overgrowth of the graft. While an exploration of the human Temporomandibular joint seems to be unethical after reconstruction with an autogenous costochondral graft for study purposes, therefore we sought to determine the growth potential of the graft by clinical evaluation. Material and methods: An experimental study was done on 96 New Zealand white male rabbits, which were divided into batches. Each batch (total 2 batches) contained 24 experimental and 24 control rabbits of known ages and species; growing (3-4) and adult (12-18) months old. TMJ arthroplasty with a costochondral graft using either 1mm or 4 mm thickness of cartilaginous cap done in both age groups. Follow-up was done regularly in batches comparing with control up to 4th, 12th, and 24th weeks of surgery to find out any relationship of behavioral change, clinical presentation, and macroscopic growth of the graft. Results: There was a relationship among the rabbits with their behavioral change, clinical presentation, and presence of growth center in the graft. Growth was found in 60% cases, 40% was growing, and 20% in adults. Conclusions: Costochondral graft had a 60% growth potentiality. The failure rate of 40% may be due to some unknown factors. Grafts grew in a greater number of growing rabbits than adults. Long time follow-up had a strong role in the growth of the graft. In conclusion, clinical evaluation of the rabbit model provided a fair estimation of the growth process.
{"title":"Clinical evaluation of growth potentiality of autogenous costochondral graft in Temporomandibular joint on New Zealand white rabbit- an experimental study","authors":"Jachmen Sultana, Quazi Billur Rahman, E. Chowdhury, Nasrin Sultana Juyena, Abul Bashar","doi":"10.15406/jdhodt.2021.12.00542","DOIUrl":"https://doi.org/10.15406/jdhodt.2021.12.00542","url":null,"abstract":"Background: Costochondral graft has been used as a substitute for a growth center in the damaged Temporomandibular joint (TMJ) in the growing children. But the relapse of the TMJ ankylosis along with facial deformity is the most common outcome after the surgery for the resorption or overgrowth of the graft. While an exploration of the human Temporomandibular joint seems to be unethical after reconstruction with an autogenous costochondral graft for study purposes, therefore we sought to determine the growth potential of the graft by clinical evaluation. Material and methods: An experimental study was done on 96 New Zealand white male rabbits, which were divided into batches. Each batch (total 2 batches) contained 24 experimental and 24 control rabbits of known ages and species; growing (3-4) and adult (12-18) months old. TMJ arthroplasty with a costochondral graft using either 1mm or 4 mm thickness of cartilaginous cap done in both age groups. Follow-up was done regularly in batches comparing with control up to 4th, 12th, and 24th weeks of surgery to find out any relationship of behavioral change, clinical presentation, and macroscopic growth of the graft. Results: There was a relationship among the rabbits with their behavioral change, clinical presentation, and presence of growth center in the graft. Growth was found in 60% cases, 40% was growing, and 20% in adults. Conclusions: Costochondral graft had a 60% growth potentiality. The failure rate of 40% may be due to some unknown factors. Grafts grew in a greater number of growing rabbits than adults. Long time follow-up had a strong role in the growth of the graft. In conclusion, clinical evaluation of the rabbit model provided a fair estimation of the growth process.","PeriodicalId":15598,"journal":{"name":"Journal of dental health, oral disorders & therapy","volume":"41 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87261081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: Angelica dahurica (A. dahurica) has the protective activity against dexamehasone-induced disorders, liver protective activity, antimutagenic activity, anti-inflammatory, anti-microbial, anti-oxidative, anti-asthmatic, and anti-cancer effects. Aims of the Study: This study aimed to investigate the synergistic antibacterial activity with existing antimicrobial agents against oral pathogen. Materials and Methods: The synergistic effects of 50% ethanol extract of A. dahurica (ADEE) were evaluated against oral bacteria, either alone or with antibiotics, via broth microdilution and time-kill method. Results: The minimal inhibitory concentrations (MICs) and minimum bactericidal concentrations (MBCs) values for ADEE, ampicillin and gentamicin against all the tested bacteria ranged between 62.5-1000/250-2000 μg/mL, 0.0625-16/0.25-32 μg/mL, and 4-128/16-256 μg/mL, respectively. The ADEE displayed synergism with ampicillin and gentamicin, with 8-fold reductions in the MIC/MBC. Furthermore, a time-kill study showed that the growth of the tested bacteria was completely attenuated after treatment with 1/2 MIC of ADEE with 1/2 MIC of antibiotics resulted from an increase of the rate of killing in units of CFU/mL to a greater degree than was observed with alone. Discussion and Conclusions: The results of this study demonstrate the antimicrobial and synergistic activity of ADEE and antibiotics against oral pathogens.
{"title":"Antimicrobial Activity of Angelica Dahurica Ethanol Extract Against Oral Bacteria","authors":"","doi":"10.33140/jodh.05.01.01","DOIUrl":"https://doi.org/10.33140/jodh.05.01.01","url":null,"abstract":"Introduction: Angelica dahurica (A. dahurica) has the protective activity against dexamehasone-induced disorders, liver protective activity, antimutagenic activity, anti-inflammatory, anti-microbial, anti-oxidative, anti-asthmatic, and anti-cancer effects. Aims of the Study: This study aimed to investigate the synergistic antibacterial activity with existing antimicrobial agents against oral pathogen. Materials and Methods: The synergistic effects of 50% ethanol extract of A. dahurica (ADEE) were evaluated against oral bacteria, either alone or with antibiotics, via broth microdilution and time-kill method. Results: The minimal inhibitory concentrations (MICs) and minimum bactericidal concentrations (MBCs) values for ADEE, ampicillin and gentamicin against all the tested bacteria ranged between 62.5-1000/250-2000 μg/mL, 0.0625-16/0.25-32 μg/mL, and 4-128/16-256 μg/mL, respectively. The ADEE displayed synergism with ampicillin and gentamicin, with 8-fold reductions in the MIC/MBC. Furthermore, a time-kill study showed that the growth of the tested bacteria was completely attenuated after treatment with 1/2 MIC of ADEE with 1/2 MIC of antibiotics resulted from an increase of the rate of killing in units of CFU/mL to a greater degree than was observed with alone. Discussion and Conclusions: The results of this study demonstrate the antimicrobial and synergistic activity of ADEE and antibiotics against oral pathogens.","PeriodicalId":15598,"journal":{"name":"Journal of dental health, oral disorders & therapy","volume":"22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85633928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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