Journal of Drug Delivery Science and Technology最新文献_第10页

Integration of ZSM-5 and Zn-HA in electrospun PBAT/PVP dressing for multifunctional acute wound healing ZSM-5和锌- ha在PBAT/PVP电纺敷料中集成用于多功能急性伤口愈合

IF 4.9 3区医学 Q1 PHARMACOLOGY & PHARMACY

Journal of Drug Delivery Science and Technology

Pub Date : 2025-12-02 DOI: 10.1016/j.jddst.2025.107856

Jiasheng Mao , Haoyu Cheng , Yubo Cui , Sizheng Huang , Zhichao Zheng , Jianhao Tong , Qi Lai , Ziyi Liu , Ling Huang , Lihong Wu , Huade Zheng

Acute wound management faces critical challenges due to conventional dressings' limitations, including poor breathability, wound adhesion, inadequate moisture maintenance, and insufficient bioactive functions. To address these challenges, we developed an electrospun dressing system based on a polyvinylpyrrolidone (PVP)/poly(butylene adipate-co-terephthalate) (PBAT) matrix. The dressing further integrated bioactive zinc hyaluronate (Zn-HA) and ZSM-5 zeolite as functional components. Zn-HA's reduced molecular weight enables deep epidermal penetration for enhanced hydration and tissue regeneration, while its zinc ions provide potent antioxidant/antibacterial effects. ZSM-5 rapidly absorbs exudates to accelerate hemostasis. The nanofiber dressings exhibited excellent biocompatibility, sustain Zn²⁺ release (a burst release of 75 % within 12 h and a cumulative release of 90 % over 96 h), and demonstrated broad-spectrum antibacterial activity against pathogens including methicillin-resistant Staphylococcus aureus (MRSA) (more than 80 % inhibition rate). Furthermore, the Zn-HA-loaded dressing remarkably reduced intracellular ROS levels by over 70 %, enhanced HUVEC migration by 76.5 % and upregulated key angiogenic genes (VEGFA, vWF, PECAM1) by more than 1.5-fold. In murine full-thickness skin defects, the dressing remarkably accelerated wound closure (94.5 % healing at day 12), suppressed inflammation, and stimulated neovascularization without systemic toxicity. The study reported the first integration of Zn-HA and ZSM-5 into electrospun fibers for wound healing applications, offering a multifunctional system for emergent hemostasis, infection control, and rapid tissue regeneration in acute wound care.

由于传统敷料的局限性，包括透气性差、伤口粘附性差、水分维持不足和生物活性功能不足，急性伤口管理面临着严峻的挑战。为了解决这些挑战，我们开发了一种基于聚乙烯吡咯烷酮(PVP)/聚己二酸丁二酯（PBAT）基质的电纺敷料系统。该敷料进一步整合了生物活性透明质酸锌（Zn-HA）和ZSM-5沸石作为功能成分。锌透明质酸的分子量降低，能够深入表皮，增强水合作用和组织再生，同时其锌离子具有强大的抗氧化/抗菌作用。ZSM-5能迅速吸收渗出物，加速止血。该纳米纤维敷料具有良好的生物相容性，可持续释放Zn2+ (12 h内爆发释放75%，96 h内累积释放90%)，并对耐甲氧西林金黄色葡萄球菌（MRSA）等病原体具有广谱抗菌活性（抑制率超过80%）。此外，负载zn - ha的敷料显著降低细胞内ROS水平超过70%，增强HUVEC迁移76.5%，上调关键血管生成基因（VEGFA, vWF, PECAM1）超过1.5倍。在小鼠全层皮肤缺损中，敷料显著加速伤口愈合（第12天愈合94.5%），抑制炎症，刺激新生血管，无全身毒性。该研究首次报道了将Zn-HA和ZSM-5整合到电纺纤维中用于伤口愈合的应用，为急性伤口护理中的紧急止血、感染控制和快速组织再生提供了多功能系统。

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引用次数: 0

Drug-loaded electrospun fibers with stabilizing sheath: prevent post-fabrication drug precipitation-induced recrystallization and controlling Molecular Relaxation for controlled release 具有稳定护套的载药静电纺丝纤维：防止制造后药物沉淀引起的再结晶和控制分子松弛以控制释放

IF 4.9 3区医学 Q1 PHARMACOLOGY & PHARMACY

Journal of Drug Delivery Science and Technology

Pub Date : 2025-12-02 DOI: 10.1016/j.jddst.2025.107812

Jinbo Liu , Yuting Hou , Yonghao Yang , Bin Wang , Xi Zhang , Yuan Tian , Gensheng Wu , Bin Gu , Zhonghua Ni , Gutian Zhao

Burst release and insufficient sustained release continue to pose significant challenges in the clinical application of pirfenidone-loading ureteral stents for treating ureteral strictures. Herein, we present a coaxial electrospun drug-loading membrane featuring an outer stabilizing sheath designed to reduce the initial burst release and enable sustained delivery of pirfenidone (PFD). The membrane consists of aligned microfibers with a core of poly(L-lactide-co-ε-caprolactone) (PLCL) encapsulating PFD, surrounded by a poly(L-lactic acid) (PLLA) sheath that acts as a diffusion-resisting and release controlling sheath. In vitro drug release experiments are conducted alongside with detailed physicochemical and mechanical analyses. The results demonstrate that the sheath effectively suppresses drug precipitation during the drying process after electrospinning. Consequently, it obviously decreases the initial burst release by about 22 % in 3 h and by around 11 % in 48 h compared with PLLA uniaxial drug-loading membrane. It is followed by a sustained release profile over 48 h, with a total drug release exceeding 90 %. Meanwhile, the molecular orientation relaxation is mitigated by about 29.9 % within the first 24 h by the sheath. Then, there is an approximately linear molecular orientation relaxation at the following stage. Furthermore, the membrane preserves its structural integrity and maintains desirable mechanical properties, such as strength and ductility, throughout the release period. These findings suggest that the stabilizing sheath is a promising method for modulating drug release profiles, offering a valuable platform for developing advanced covered stents.

负荷吡非尼酮输尿管支架治疗输尿管狭窄的临床应用中，突发性释放和持续释放不足仍然是一个重大挑战。在此，我们提出了一种同轴电纺丝载药膜，其外稳定鞘旨在减少初始爆发释放并使吡非尼酮（PFD）持续递送。该膜由排列的微纤维组成，其核心是包封PFD的聚l -乳酸-co-ε-己内酯（PLCL），周围是聚l -乳酸（PLLA）护套，作为抵抗扩散和控制释放的护套。体外药物释放实验与详细的物理化学和力学分析一起进行。结果表明，鞘层能有效抑制静电纺丝后干燥过程中的药物沉淀。因此，与PLLA单轴载药膜相比，它在3小时内明显降低了约22%的初始爆发释放，在48小时内明显降低了约11%。随后是超过48小时的缓释概况，总药物释放超过90%。同时，分子取向弛豫在前24 h内被鞘层抑制了约29.9%。然后，在接下来的阶段有一个近似线性的分子取向弛豫。此外，在整个释放期内，膜保持其结构完整性，并保持理想的机械性能，如强度和延展性。这些发现表明，稳定鞘是一种很有前途的调节药物释放谱的方法，为开发先进的覆盖支架提供了有价值的平台。

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引用次数: 0

Chitosan-based systems for advanced wound healing 基于壳聚糖的先进伤口愈合系统

IF 4.9 3区医学 Q1 PHARMACOLOGY & PHARMACY

Journal of Drug Delivery Science and Technology

Pub Date : 2025-12-02 DOI: 10.1016/j.jddst.2025.107843

Neha Raina , Rohit Kumar , Bunty Sharma , Hardeep Singh Tuli , Ujjawal Sharma , Dattatray J. Late , Akhilesh Kumar , Keshav Raj Paudel , Madhu Gupta

The rising incidences of impaired wound repair impose a substantial financial burden on the healthcare sector, driving a growing interest in wound healing solutions. It has inspired scientists to develop innovative wound dressings with enhanced healing capabilities. Specifically, chitosan-based systems demonstrate a non-toxic nature, biocompatibility, and bioactivity and stand out as excellent candidates for wound healing applications. Chitosan-based systems exhibit outstanding healing potential by accelerating new skin cell development, reducing inflammation, and preventing infections. This article intends to summarize the current advancements and issues involving using chitosan-based systems in developing advanced wound dressings. This review starts with an outline of the wound repair process and progresses to a detailed discussion of the properties of chitosan and chitosan-based systems in this context. The mechanisms by which chitosan-based systems contribute to wound healing are critically analyzed across key stages, including promotion of hemostasis, angiogenesis, collagen deposition, and wound closure acceleration. Additionally, findings from various studies are comprehensively reviewed, furthermore, the market analysis of chitosan-based systems and the use of chitosan as an anti-biofilm agent are critically examined. The literature review identifies existing research gaps and highlights potential directions for future exploration. Current evidence indicates that chitosan-based systems own exceptional wound repair properties, whether used independently or for encapsulating therapeutic agents. These findings underscore the significant opportunities and potential of chitosan-based systems for advancing wound repair applications.

伤口修复损伤的发生率不断上升，对医疗保健部门造成了巨大的经济负担，推动了对伤口愈合解决方案日益增长的兴趣。它激发了科学家们开发具有增强愈合能力的创新伤口敷料。具体来说，壳聚糖为基础的系统具有无毒性、生物相容性和生物活性，是伤口愈合应用的优秀候选者。壳聚糖为基础的系统表现出突出的愈合潜力，加速新的皮肤细胞的发展，减少炎症和预防感染。本文综述了壳聚糖为基础的系统在开发先进创面敷料方面的最新进展和存在的问题。本文首先概述了伤口修复过程，然后详细讨论了壳聚糖和壳聚糖基系统的特性。壳聚糖系统促进伤口愈合的机制在关键阶段进行了批判性分析，包括促进止血、血管生成、胶原沉积和伤口愈合加速。此外，全面回顾了各种研究结果，并对壳聚糖基系统的市场分析和壳聚糖作为抗生物膜剂的应用进行了严格的审查。文献综述确定了现有的研究差距，并强调了未来探索的潜在方向。目前的证据表明，壳聚糖为基础的系统具有特殊的伤口修复性能，无论是独立使用或封装治疗剂。这些发现强调了壳聚糖为基础的系统在推进伤口修复应用方面的重大机遇和潜力。

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引用次数: 0

Leveraging intrinsic FSM-16 properties for high-capacity, sustained doxorubicin release and superior long-term anti-proliferative activity in vitro 利用固有的FSM-16特性，高容量，持续释放阿霉素和卓越的长期体外抗增殖活性

IF 4.9 3区医学 Q1 PHARMACOLOGY & PHARMACY

Journal of Drug Delivery Science and Technology

Pub Date : 2025-12-02 DOI: 10.1016/j.jddst.2025.107859

Fereshte Kalhori , Ali Teimoori , Rezvan Najafi , Zahra Allahyari , Hadi Samadian

The primary objective of the present study is to synthesize and characterize a sophisticated anticancer nanoformulation based on folded sheet mesoporous (FSM) nanostructures as a carrier for doxorubicin (DOX) against breast cancer cells. The FSMs were synthesized using the hydrothermal method and characterized. Drug release was evaluated at pH 7.4 and 5.5 to simulate normal and tumor-like environments, respectively. Breast cancer cell lines were assessed for viability using the MTT assay, cytotoxicity using Live-Dead labeling, and migration via wound healing experiments, as well as proliferation through colony formation, cell cycle progression by flow cytometry, and apoptosis using Annexin V-Propidium iodide (PI) staining. FSM exhibited a uniform mesoporous structure and achieved a DOX loading capacity of 29 %. Drug release was pH-dependent, with 72 % of DOX released at pH 5.5 compared to only 12 % at pH 7.4. FSM-16@DOX demonstrated reduced cytotoxicity in normal cells while significantly inhibiting the migration and colony formation of cancer cells, showing greater effectiveness than free DOX. Both treatments induced G2/M cell cycle arrest and apoptosis, although free DOX exhibited slightly higher cytotoxicity. FSM-16@DOX shows promise as a pH-responsive nanocarrier for targeted delivery of DOX, enhancing anticancer efficacy while minimizing toxicity. Further in vivo studies and investigations into the underlying molecular mechanisms are needed to establish its full potential for clinical use.

本研究的主要目的是合成并表征一种基于折叠片介孔（FSM）纳米结构的复杂抗癌纳米制剂，作为阿霉素（DOX）抗乳腺癌细胞的载体。采用水热法合成了fsm，并对其进行了表征。在pH为7.4和5.5时评估药物释放，分别模拟正常和肿瘤样环境。使用MTT法评估乳腺癌细胞系的活力，使用活死标记法评估细胞毒性，通过伤口愈合实验评估迁移，通过集落形成评估增殖，通过流式细胞术评估细胞周期进展，使用膜联蛋白v -碘化丙啶（PI）染色评估凋亡。FSM表现出均匀的介孔结构，达到29%的DOX负载能力。药物释放是pH依赖性的，pH为5.5时72%的DOX释放，而pH为7.4时仅12%。FSM-16@DOX在正常细胞中显示出降低细胞毒性，同时显著抑制癌细胞的迁移和集落形成，显示出比游离DOX更大的有效性。两种处理均诱导G2/M细胞周期阻滞和凋亡，尽管游离DOX表现出稍高的细胞毒性。FSM-16@DOX是一种ph响应纳米载体，用于靶向递送DOX，增强抗癌功效，同时将毒性降到最低。需要进一步的体内研究和对潜在分子机制的调查来确定其临床应用的全部潜力。

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引用次数: 0

Herbal-infused PEI/PAA coated magnesium stitches: A drug delivery system for skin regeneration and controlled release 草药注入PEI/PAA涂层镁针：一种皮肤再生和控释的药物输送系统

IF 4.9 3区医学 Q1 PHARMACOLOGY & PHARMACY

Journal of Drug Delivery Science and Technology

Pub Date : 2025-12-02 DOI: 10.1016/j.jddst.2025.107829

Nauman Javed , Hina Saeed , Muhammad Shoaib Butt

Biodegradable magnesium (Mg) alloy stitches have gained attention for their potential in wound closure, especially when integrated with controlled drug delivery systems. However, challenges such as rapid degradation in physiological environments, uncontrolled drug release, and increased susceptibility to infection hinder their widespread clinical use. This study presents herbal-infused PEI/PAA-coated magnesium stitches, designed to offer sustained therapeutic release, enhance skin regeneration, and address challenges such as rapid degradation and infection susceptibility. The coating incorporates a polycation–polyanion multilayer matrix infused with Cocos nucifera extract to improve mechanical durability, modulate degradation, and enable controlled therapeutic release. Surface characterization (FTIR, SEM/EDS) confirmed uniform multilayer formation. Mechanical testing revealed an increase in tensile strength from ∼240 N (uncoated) to ∼267 N (coated), confirming structural integrity under physiological stress. The coated wires demonstrated a 78 % reduction in corrosion rate in simulated gastric fluid and 69 % reduction in simulated intestinal fluid at Day 14, compared to complete degradation of uncoated controls. Drug loading efficiency was 67.54 ± 0.32 %, and in vitro release studies revealed a biphasic profile, which was evaluated by the Gallagher–Corrigan model (R² = 0.99995, RMSE = 0.89 %). An initial burst (18.22 % release within 2.1 h) was followed by sustained release driven by matrix erosion over 120 h. Biological assessments confirmed antibacterial activity against E. coli, S. aureus, and K. pneumoniae (inhibition zones up to 24 mm), <1 % hemolysis, and >85 % cell viability, validating the coating's biocompatibility. In vivo histological evaluation in the rat wound model revealed wound closure under 10 Days, where the treated group had achieved near-complete wound closure by Day 8, enhanced fibroblast proliferation, and organized collagen deposition around the coated implants.

可生物降解镁（Mg）合金缝线因其在伤口闭合方面的潜力而受到关注，特别是当与受控药物输送系统结合使用时。然而，生理环境中的快速降解、不受控制的药物释放以及对感染的易感性增加等挑战阻碍了它们的广泛临床应用。本研究介绍了草药注入PEI/ paa涂层镁线，旨在提供持续的治疗释放，增强皮肤再生，并解决快速降解和感染易感性等挑战。该涂层包含注入椰果提取物的聚阳离子-聚阴离子多层基质，以提高机械耐久性，调节降解，并实现控制治疗释放。表面表征（FTIR, SEM/EDS）证实了均匀的多层结构。力学测试显示，拉伸强度从~ 240 N（未涂覆）增加到~ 267 N（涂覆），证实了生理应力下的结构完整性。第14天，与未涂覆的对照组相比，涂覆金属丝在模拟胃液中的腐蚀率降低了78%，在模拟肠液中的腐蚀率降低了69%。载药效率为67.54±0.32%，体外释放呈双相分布，采用Gallagher-Corrigan模型（R2 = 0.99995, RMSE = 0.89%）进行评价。最初的爆发（2.1小时内释放18.22%）随后在120小时内由基质侵蚀驱动持续释放。生物学评估证实了对大肠杆菌、金黄色葡萄球菌和肺炎克雷伯菌的抗菌活性（抑制区达24 mm），溶血率为1%，细胞存活率为85%，验证了涂层的生物相容性。大鼠伤口模型的体内组织学评估显示伤口在10天内愈合，治疗组在第8天接近完全愈合，成纤维细胞增殖增强，胶原蛋白在包被植入物周围有组织沉积。

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引用次数: 0

Corrigendum to “Transdermal codelivery system of resveratrol nanocrystals and fluorouracil@ HP-β-CD by dissolving microneedles for cutaneous melanoma treatment” [J. Drug Deliv. Sci. Technol. 91 (2024) 1 –10 105257] 白藜芦醇纳米晶体与氟尿嘧啶@ HP-β-CD溶微针经皮共给药系统治疗皮肤黑色素瘤[J]。药物Deliv。科学。科技。91 (2024)1 -10 [5257]

IF 4.9 3区医学 Q1 PHARMACOLOGY & PHARMACY

Journal of Drug Delivery Science and Technology

Pub Date : 2025-12-01 DOI: 10.1016/j.jddst.2025.107480

Yingying Ma , Yanchao Liu , Yancai Wang , Peng Gao

引用次数: 0

Phospholipid-stabilized atropine nanoemulsion for pediatric myopia control: enhanced ocular retention, permeability, stability 用于小儿近视控制的磷脂稳定阿托品纳米乳：增强眼潴留、渗透性、稳定性

IF 4.9 3区医学 Q1 PHARMACOLOGY & PHARMACY

Journal of Drug Delivery Science and Technology

Pub Date : 2025-12-01 DOI: 10.1016/j.jddst.2025.107857

Dongmei Shi , Muse Ji , Xiaohong Xu , Mei Chen , Jingxin Gou , Haibing He , Tian Yin , Xing Tang , Yu Zhang

Purpose

The therapeutic utility of atropine is limited by its hydrolysis-prone ester bond, which leads to the formation of tropic acid (TRA), a potentially toxic degradation product. To overcome this limitation, we developed a novel atropine nanoemulsion (ATR-NE) as a safer drug delivery system for the prevention and management of myopia.

Methods

ATR-NE was prepared by high-pressure homogenization. The formulation was optimized by Box-Behnken Design with particle size (PS), polydispersity index (PDI) and entrapment efficiency (EE) as dependent variables. Structural and functional characterization was performed using transmission electron microscopy (TEM), atomic force microscopy (AFM), rheological analysis, and molecular docking studies. Subsequently, safety was evaluated in vitro using a rabbit model by assessing ocular irritation scores, intraocular pressure (IOP), tear film break-up time (TUBT), and histopathological analysis. Finally, its therapeutic efficacy was comprehensively evaluated using an induced myopia guinea pig model.

Results

ATR-NE with small and uniform particle size was successfully prepared. The TRA content of the optimized ATE-NE was less than 0.2 % within six months. ATR-NE exhibits excellent in vitro and in vivo compatibility. Furthermore, ATR-NE exhibited a novel system with enhanced retention ability, along with improved corneal permeability and scleral distribution. Notably, the 0.005 % ATR-NE demonstrated comparable efficacy to ATR eye solution drops. Furthermore, ATR-NE effectively alleviated dry eye symptoms potentially induced by the long-term use of ATR solution eye drops.

Conclusion

The ATR-NE, characterized by its robust physicochemical stability and remarkable efficacy, will represents a much more appealing strategy for myopic progression.

目的：阿托品的治疗作用受到其易水解的酯键的限制，这导致了热带酸（TRA）的形成，这是一种潜在的毒性降解产物。为了克服这一限制，我们开发了一种新的阿托品纳米乳（ATR-NE）作为一种更安全的药物递送系统，用于预防和治疗近视。方法采用高压均质法制备satr - ne。以粒径（PS）、多分散性指数（PDI）和捕集效率（EE）为因变量，采用Box-Behnken设计优化配方。通过透射电子显微镜（TEM）、原子力显微镜（AFM）、流变学分析和分子对接研究进行了结构和功能表征。随后，通过评估眼刺激评分、眼内压（IOP）、泪膜破裂时间（TUBT）和组织病理学分析来评估体外兔模型的安全性。最后，利用诱发性近视豚鼠模型对其治疗效果进行综合评价。结果制备出粒径小、均匀的satr - ne。优化后的ATE-NE在6个月内TRA含量低于0.2%。ATR-NE具有良好的体内外相容性。此外，ATR-NE表现出一种新的系统，具有增强的保留能力，以及改善的角膜渗透性和巩膜分布。值得注意的是，0.005%的ATR- ne显示出与ATR滴眼液相当的疗效。此外，ATR- ne有效缓解了长期使用ATR溶液滴眼液可能引起的干眼症状。结论ATR-NE具有良好的物理化学稳定性和显著的疗效，将成为治疗近视进展的一种更有吸引力的策略。

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引用次数: 0

Corrigendum to “Engineering a curcumin-myricetin co-amorphous system: Hydrogen bond-driven solubility & bioavailability enhancement with 16.7-Fold oral exposure boost” [J. Drug Deliv. Sci. Technol. 114 Part A (2025) 107439] “工程姜黄素-杨梅素共无定形体系：氢键驱动的溶解度和生物利用度提高与16.7倍口服暴露”的更正[J]。药物Deliv。科学。第114号技术A部分（2025）107439]

IF 4.9 3区医学 Q1 PHARMACOLOGY & PHARMACY

Journal of Drug Delivery Science and Technology

Pub Date : 2025-12-01 DOI: 10.1016/j.jddst.2025.107465

Jie Zhang , Huan Xu , Xiaofen Xu , Ming Yan , Zirui Yu , Xiaofang Qian , Xiaoli Liu , Jing Zhu

引用次数: 0

A review of natural and synthetic polymers in transdermal drug delivery as soluble microneedles 水溶性微针经皮给药的天然聚合物和合成聚合物综述

IF 4.9 3区医学 Q1 PHARMACOLOGY & PHARMACY

Journal of Drug Delivery Science and Technology

Pub Date : 2025-12-01 DOI: 10.1016/j.jddst.2025.107841

Mohanna Sharifi , Mohamadreza Shahnazari , Sina Razzaghi , Kambiz Vafai

Transdermal drug delivery is gaining prominence as a non-invasive and patient-friendly alternative to conventional administration routes. Among physical enhancement strategies, microneedles stand out for their ability to bypass the stratum corneum and enable controlled delivery without pain. This review focuses on soluble microneedles made from natural and synthetic biodegradable polymers, which dissolve in the skin to release active pharmaceutical ingredients. We summarize the main fabrication techniques (i.e. micro-molding, 3D printing, and centrifugal lithography) and compare their efficiency, scalability, and compatibility with sensitive drugs. Key classes of polymers such as hyaluronic acid, collagen, silk fibroin, polyvinylpyrrolidone (PVP), and polyvinyl alcohol (PVA) are examined with respect to their mechanical strength, dissolution behavior, and drug-release profiles. Applications in vaccination, cancer therapy, diabetes management, and dermatology highlight the versatility of polymer-based microneedles. Overall, the findings indicate that polymer microneedles offer a robust platform for targeted and minimally invasive drug delivery, though future work must address material limitations, large-scale manufacturing, and regulatory approval to accelerate clinical translation.

透皮给药作为传统给药途径的一种非侵入性和对患者友好的替代方法，正日益受到重视。在物理增强策略中，微针因其绕过角质层的能力而脱颖而出，并且能够在没有疼痛的情况下控制分娩。本文综述了由天然和合成的可生物降解聚合物制成的可溶性微针，这些微针可溶解于皮肤中，释放出有效的药物成分。我们总结了主要的制造技术（即微成型、3D打印和离心光刻），并比较了它们的效率、可扩展性和与敏感药物的相容性。主要类型的聚合物，如透明质酸、胶原蛋白、丝素蛋白、聚乙烯吡咯烷酮（PVP）和聚乙烯醇（PVA）的机械强度、溶解行为和药物释放谱进行了研究。在疫苗接种、癌症治疗、糖尿病管理和皮肤病学方面的应用突出了聚合物微针的多功能性。总的来说，研究结果表明聚合物微针为靶向和微创给药提供了一个强大的平台，尽管未来的工作必须解决材料限制、大规模生产和监管批准，以加速临床转化。

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引用次数: 0

Corrigendum to “Antimicrobial chitosan-silk fibroin scaffolds with green-synthesized metal oxide nanoparticles” [J. Drug Deliv. Sci. Technol. 114 Part A (2025) 107463] “抗菌壳聚糖-丝素蛋白支架与绿色合成的金属氧化物纳米颗粒”的更正”[J]。药物Deliv。科学。第114号技术A部分（2025）107463]

IF 4.9 3区医学 Q1 PHARMACOLOGY & PHARMACY

Journal of Drug Delivery Science and Technology

Pub Date : 2025-12-01 DOI: 10.1016/j.jddst.2025.107684

Denisa-Maria Radulescu , Bodgan Stefan Vasile , Vasile-Adrian Surdu , Roxana-Doina Trusca , Cornelia-Ioana Ilie , Roxana Cristina Popescu , Ecaterina Andronescu , Veronica Drumea , Lia-Mara Ditu

引用次数: 0