Journal of endodontics最新文献

英文中文

Research on Registration Strategy for Guided Endodontics 引导牙髓学配准策略研究。

IF 3.6 2区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of endodontics

Pub Date : 2026-03-01 Epub Date: 2025-11-06 DOI: 10.1016/j.joen.2025.10.017

Chang Liu DDS , Longfei Ma PhD , Yaopeng Zhang MEng , Yanmei Dong PhD , Xudong Bao PhD

Introduction

The objective of this study was to evaluate which registration strategy (the number, configuration, and distribution range of fiducial markers) could obtain the optimal registration accuracy for guided root canal therapy.

Methods

One 3-dimensional-printed mandibular jaw model was created. The fiducial markers used for registration were prepared on the crowns of anterior and posterior teeth. The models were scanned using cone-beam computed tomography, and digital models were built. Different numbers (3, 4, 6, 8, and 10), configurations (quadrilateral, triangular, and linear) and distribution ranges (target tooth, adjacent teeth, and mandibular dentition) of fiducial markers were applied for registration of the dynamic navigation system. The target registration error (TRE) was measured. One-way analysis of variance was applied to assess registration error between groups. The significance level was set at .05.

Results

The TREs of 4 markers were significantly lower than those of three for both anterior tooth (0.32 mm vs 0.62 mm; P < .05) and posterior tooth (0.22 mm vs 1.43 mm; P < .05); increasing the number of markers to ten did not further reduce the TREs (P > .05). The TREs of markers arranged in a quadrilateral configuration were significantly lower than those in linear and triangular configurations (P < .05). The TREs of the markers selected on the target tooth and adjacent teeth were significantly lower than those in the mandibular dentition region for anterior tooth (P < .05).

Conclusions

In endodontic treatment, the best registration accuracy was obtained by selecting four spatial quadrilateral fiducial markers localized around the target tooth.

本研究的目的是评估哪种注册策略（基准标记物的数量、配置和分布范围）可以获得引导根管治疗的最佳注册精度。方法：建立三维打印下颌骨模型。在前牙和后牙的冠上制备用于配准的基准标记物。采用锥形束计算机断层扫描（CBCT）对模型进行扫描，并建立数字模型。采用不同数量（3、4、6、8、10）、不同构型（四边形、三角形、线性）、不同分布范围（目标牙、邻牙、下颌牙列）的基准标记进行动态导航系统配准。测量目标配准误差（TRE）。采用单因素方差分析（ANOVA）评估组间注册误差。显著性水平设为0.05。结果：4种标记物的TREs均显著低于前牙（0.32 mm比0.62 mm, P < 0.05）和后牙（0.22 mm比1.43 mm, P < 0.05）；标记数增加到10个后，TREs没有进一步降低（P < 0.05）。四边形排列标记的TREs显著低于线性和三角形排列标记（P < 0.05）。标记物在目标牙及邻牙上的TREs均显著低于前牙全列区域的TREs （P < 0.05）。结论：在根管治疗中，选择定位于目标牙周围的四个空间四边形基准标记可获得最佳的配准精度。

{"title":"Research on Registration Strategy for Guided Endodontics","authors":"Chang Liu DDS , Longfei Ma PhD , Yaopeng Zhang MEng , Yanmei Dong PhD , Xudong Bao PhD","doi":"10.1016/j.joen.2025.10.017","DOIUrl":"10.1016/j.joen.2025.10.017","url":null,"abstract":"<div><h3>Introduction</h3><div>The objective of this study was to evaluate which registration strategy (the number, configuration, and distribution range of fiducial markers) could obtain the optimal registration accuracy for guided root canal therapy.</div></div><div><h3>Methods</h3><div>One 3-dimensional-printed mandibular jaw model was created. The fiducial markers used for registration were prepared on the crowns of anterior and posterior teeth. The models were scanned using cone-beam computed tomography, and digital models were built. Different numbers (3, 4, 6, 8, and 10), configurations (quadrilateral, triangular, and linear) and distribution ranges (target tooth, adjacent teeth, and mandibular dentition) of fiducial markers were applied for registration of the dynamic navigation system. The target registration error (TRE) was measured. One-way analysis of variance was applied to assess registration error between groups. The significance level was set at .05.</div></div><div><h3>Results</h3><div>The TREs of 4 markers were significantly lower than those of three for both anterior tooth (0.32 mm vs 0.62 mm; <em>P</em> < .05) and posterior tooth (0.22 mm vs 1.43 mm; <em>P</em> < .05); increasing the number of markers to ten did not further reduce the TREs (<em>P</em> > .05). The TREs of markers arranged in a quadrilateral configuration were significantly lower than those in linear and triangular configurations (<em>P</em> < .05). The TREs of the markers selected on the target tooth and adjacent teeth were significantly lower than those in the mandibular dentition region for anterior tooth (<em>P</em> < .05).</div></div><div><h3>Conclusions</h3><div>In endodontic treatment, the best registration accuracy was obtained by selecting four spatial quadrilateral fiducial markers localized around the target tooth.</div></div>","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":"52 3","pages":"Pages 429-435"},"PeriodicalIF":3.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145476925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Top 100 Most Cited Articles on Antibiotics in Endodontics: A Bibliometric Analysis 牙髓学抗生素100篇最常被引文章：文献计量分析。

IF 3.6 2区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of endodontics

Pub Date : 2026-03-01 Epub Date: 2025-11-21 DOI: 10.1016/j.joen.2025.10.008

Hajar Albanyan BDS, MSc, Dip ABE , Mohammed Asseery DMD , Haitham Alahmari DDS , Ikram Ul Haq MLIS , Ali Alaqla BDS, CAGS, MS, FRCDC, Dip ABE, DMSc

Introduction

This bibliometric study aimed to evaluate the 100 most cited articles on antibiotics in endodontics using the Web of Science database.

Methods

Articles were identified using the keywords “Endodontics” AND “Antibiotics” and ranked by citation count. Key bibliometric indicators including publication and citation trends, study designs, levels of evidence, top sources, authors, countries, institutions, and most frequently occurring keywords were analyzed using Microsoft Excel version-16 and Visualization of Similarities Viewer.

Result

The top 100 most cited articles were published between 1954 and 2022, across 40 different sources, and were authored by 397 researchers from 30 countries. Most publications (76%) were from 2006 to 2019. The United States, Brazil, and England were the leading contributors. Cross-sectional studies and reviews were the most common designs with level of evidence V dominating the database and showing the highest citation impact. The Journal of Endodontics and International Endodontic Journal were the top sources.

Conclusion

This upward trend over the past 2 decades reflects advancements in oral health education and growing research interest. This analysis highlights the influential publications and research trends, offering valuable insights for future studies, clinical practice, and academic collaboration in antibiotic used for endodontic therapy.

本文献计量学研究旨在利用Web of Science （WoS）数据库评估100篇被引最多的牙髓学抗生素相关文章。方法：采用关键词“牙髓学”和“抗生素”对文献进行检索，并按被引次数排序。使用Microsoft Excel version-16和可视化相似度查看器（VOSviewer）分析关键文献计量指标，包括出版和引用趋势、研究设计、证据水平、主要来源、作者、国家、机构和最频繁出现的关键词。结果：被引用次数最多的100篇文章发表于1954年至2022年之间，来自40个不同的来源，由来自30个国家的397名研究人员撰写。大多数出版物（76%）发表于2006年至2019年。美国、巴西和英国是主要贡献者。横截面研究和综述是最常见的设计，证据水平（LoE） V主导数据库，显示出最高的引用影响。牙髓学杂志和国际牙髓学杂志是最主要的来源。结论：在过去的二十年中，这种上升趋势反映了口腔健康教育的进步和研究兴趣的增加。该分析突出了有影响力的出版物和研究趋势，为牙髓治疗抗生素的未来研究、临床实践和学术合作提供了有价值的见解。

{"title":"Top 100 Most Cited Articles on Antibiotics in Endodontics: A Bibliometric Analysis","authors":"Hajar Albanyan BDS, MSc, Dip ABE , Mohammed Asseery DMD , Haitham Alahmari DDS , Ikram Ul Haq MLIS , Ali Alaqla BDS, CAGS, MS, FRCDC, Dip ABE, DMSc","doi":"10.1016/j.joen.2025.10.008","DOIUrl":"10.1016/j.joen.2025.10.008","url":null,"abstract":"<div><h3>Introduction</h3><div>This bibliometric study aimed to evaluate the 100 most cited articles on antibiotics in endodontics using the Web of Science database.</div></div><div><h3>Methods</h3><div>Articles were identified using the keywords “Endodontics” AND “Antibiotics” and ranked by citation count. Key bibliometric indicators including publication and citation trends, study designs, levels of evidence, top sources, authors, countries, institutions, and most frequently occurring keywords were analyzed using Microsoft Excel version-16 and Visualization of Similarities Viewer.</div></div><div><h3>Result</h3><div>The top 100 most cited articles were published between 1954 and 2022, across 40 different sources, and were authored by 397 researchers from 30 countries. Most publications (76%) were from 2006 to 2019. The United States, Brazil, and England were the leading contributors. Cross-sectional studies and reviews were the most common designs with level of evidence V dominating the database and showing the highest citation impact. The Journal of Endodontics and International Endodontic Journal were the top sources.</div></div><div><h3>Conclusion</h3><div>This upward trend over the past 2 decades reflects advancements in oral health education and growing research interest. This analysis highlights the influential publications and research trends, offering valuable insights for future studies, clinical practice, and academic collaboration in antibiotic used for endodontic therapy.</div></div>","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":"52 3","pages":"Pages 345-352"},"PeriodicalIF":3.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145587689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Letter to the Editor: Comparing the Effectiveness of a Robotic and Dynamic Navigation System in Fiber Postremoval: An In Vitro Study 致编辑：比较机器人和动态导航系统在纤维后移中的有效性：一项体外研究。

IF 3.6 2区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of endodontics

Pub Date : 2026-03-01 Epub Date: 2026-01-07 DOI: 10.1016/j.joen.2025.12.003

Hinpetch Daungsupawong PhD, Viroj Wiwanitkit MD

引用次数: 0

Authors’ Reply to the Commentary on “Comparing the Effectiveness of a Robotic and Dynamic Navigation System in Fiber Post Removal: An In Vitro Study” 作者对“比较机器人和动态导航系统在纤维桩去除中的有效性：一项体外研究”评论的回复。

IF 3.6 2区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of endodontics

Pub Date : 2026-03-01 Epub Date: 2026-01-27 DOI: 10.1016/j.joen.2025.12.004

Duo Zhou MDS, Fulu Xu MDS, Jiayun Dai MDS, Xingyang Wang MDS, Yifan Ping MDS, Juan Wang PhD, DDS

引用次数: 0

Guidelines for Authors 作者指南

IF 3.6 2区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of endodontics

Pub Date : 2026-03-01 Epub Date: 2026-03-06 DOI: 10.1016/S0099-2399(26)00046-4

引用次数: 0

Associate Registry 将注册表

IF 3.6 2区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of endodontics

Pub Date : 2026-03-01 Epub Date: 2026-03-06 DOI: 10.1016/S0099-2399(26)00066-X

引用次数: 0

Apical Dentin Microcrack Formation After Ultrasonic Instrumentation in Flattened Root Canals: A Comparative Analysis Using Micro-computed Tomography and Optical Coherence Tomography 扁平根管超声检查后牙本质微裂纹的形成：微计算机断层扫描与光学相干断层扫描的对比分析。

IF 3.6 2区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of endodontics

Pub Date : 2026-03-01 Epub Date: 2025-12-09 DOI: 10.1016/j.joen.2025.11.024

Mariana Pereira de Souza da Silva MSc , Adriana da Costa Ribeiro PhD , Jeynifer Rafaella Bezerra de Oliveira PhD , Daniel Amancio Duarte MSc , Bruno Felipe de Carvalho BSc , Yaicel Ge Proenza PhD , Natália Maria Velozo dos Santos Mendonça MSc , Anderson Stevens Leonidas Gomes PhD

Introduction

Although ultrasonic inserts are frequently used for the instrumentation of flat root canals, there is a lack of studies investigating whether instrument contact with the canal walls induces the formation of dentinal microcracks. This study aimed to evaluate the formation of apical microcracks, caused by ultrasonic instrumentation, using micro-computed tomography (microCT) and optical coherence tomography (OCT).

Method

Twenty maxillary second premolars were randomly divided into 2 groups (n = 10): ultrasonic group and brushing group. All specimens were initially prepared using Reciproc Blue files 25/.05 and 40/.06. The brushing group received additional brushing movements with Reciproc Blue 40/.06 and the ultrasonic group underwent instrumentation with a Clearsonic Black ultrasonic insert. Pre- and post-instrumentation images were obtained using both microCT and OCT and were analyzed with specialized software.

Results

Statistically significant difference was observed for the treatment variable regarding apical microcrack presence (P < .05). In the brushing group, all apical microcracks identified post-instrumentation were also present preoperatively. In contrast, new incidences were identified in the ultrasonic group via microCT. No significant differences were found for the evaluator (P > .05) or the imaging technique used (P > .05). Intra- and interexaminer agreement was nearly perfect, with kappa values ranging from 0.858 to 0.975.

Conclusion

The inclusion of an ultrasonic insert during biomechanical preparation did not significantly increase the incidence of apical microcracks when compared with a nonultrasonic protocol. OCT demonstrated high reliability for detecting apical microcracks in extracted teeth.

导言：虽然超声植入物经常用于平根管的预备，但缺乏关于器械与根管壁接触是否会诱发牙本质微裂纹形成的研究。本研究旨在利用显微计算机断层扫描（microCT）和光学相干断层扫描（OCT）评估超声仪器引起的根尖微裂纹的形成。方法：20颗上颌第二前磨牙随机分为两组（n = 10）：超声组和刷牙组。所有标本最初使用Reciproc Blue锉25/.05和40/.06制备。刷牙组使用Reciproc Blue 40/.06进行额外的刷牙运动，而超声波组使用Clearsonic Black超声波插入物进行仪器检测。使用微计算机断层扫描（microCT）和光学相干断层扫描（OCT）获得仪器前和仪器后的图像，并用专门的软件进行分析。结果：根尖微裂是否存在的治疗变量与影像学检查的差异有统计学意义（p < 0.05）。审查员内部和审查员之间的一致性近乎完美，kappa值在0.858 ~ 0.975之间。结论：与非超声方案相比，在生物力学准备过程中加入超声插入物并没有显著增加根尖微裂纹的发生率。OCT对拔除牙的根尖微裂检测具有较高的可靠性。

{"title":"Apical Dentin Microcrack Formation After Ultrasonic Instrumentation in Flattened Root Canals: A Comparative Analysis Using Micro-computed Tomography and Optical Coherence Tomography","authors":"Mariana Pereira de Souza da Silva MSc , Adriana da Costa Ribeiro PhD , Jeynifer Rafaella Bezerra de Oliveira PhD , Daniel Amancio Duarte MSc , Bruno Felipe de Carvalho BSc , Yaicel Ge Proenza PhD , Natália Maria Velozo dos Santos Mendonça MSc , Anderson Stevens Leonidas Gomes PhD","doi":"10.1016/j.joen.2025.11.024","DOIUrl":"10.1016/j.joen.2025.11.024","url":null,"abstract":"<div><h3>Introduction</h3><div>Although ultrasonic inserts are frequently used for the instrumentation of flat root canals, there is a lack of studies investigating whether instrument contact with the canal walls induces the formation of dentinal microcracks. This study aimed to evaluate the formation of apical microcracks, caused by ultrasonic instrumentation, using micro-computed tomography (microCT) and optical coherence tomography (OCT).</div></div><div><h3>Method</h3><div>Twenty maxillary second premolars were randomly divided into 2 groups (<em>n</em> = 10): ultrasonic group and brushing group. All specimens were initially prepared using Reciproc Blue files 25/.05 and 40/.06. The brushing group received additional brushing movements with Reciproc Blue 40/.06 and the ultrasonic group underwent instrumentation with a Clearsonic Black ultrasonic insert. Pre- and post-instrumentation images were obtained using both microCT and OCT and were analyzed with specialized software.</div></div><div><h3>Results</h3><div>Statistically significant difference was observed for the treatment variable regarding apical microcrack presence (<em>P</em> < .05). In the brushing group, all apical microcracks identified post-instrumentation were also present preoperatively. In contrast, new incidences were identified in the ultrasonic group via microCT. No significant differences were found for the evaluator (<em>P</em> > .05) or the imaging technique used (<em>P</em> > .05). Intra- and interexaminer agreement was nearly perfect, with kappa values ranging from 0.858 to 0.975.</div></div><div><h3>Conclusion</h3><div>The inclusion of an ultrasonic insert during biomechanical preparation did not significantly increase the incidence of apical microcracks when compared with a nonultrasonic protocol. OCT demonstrated high reliability for detecting apical microcracks in extracted teeth.</div></div>","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":"52 3","pages":"Pages 458-463"},"PeriodicalIF":3.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145742942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immunohistological Characterization of Minced Dental Pulp Transplant in an Ectopic Mouse Model 异位小鼠碎牙髓移植模型的免疫组织学特征。

IF 3.6 2区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of endodontics

Pub Date : 2026-03-01 Epub Date: 2025-12-17 DOI: 10.1016/j.joen.2025.11.017

Chaehwan Lee DDS, MS , Yuka Miyamoto DDS, PhD , Wei Chen PhD , Euiseong Kim DDS, MSD, PhD , Insoon Chang DDS, MS, PhD , Mo K. Kang DDS, PhD

Introduction

Dental pulp stem cells have been explored as a potential source for dentin–pulp complex regeneration because of their pluripotency and differentiation capacity. However, cell-based approaches require enzymatic digestion and in vitro expansion, which may alter cell properties and hinder clinical translation. This preliminary proof-of-principle study examines a tissue-based alternative using freshly minced pulp (MP) in an ectopic mouse model as a potentially translatable approach for regenerative endodontics.

Methods

Human dental pulp tissue was either minced or enzymatically digested, seeded onto collagen type I scaffolds, inserted into root fragments, and implanted subcutaneously into immunocompromised mice.

Results

Histology revealed that MP grafting generated well-organized dentin–pulp–like tissue with high cellularity, vascularization, mineralization, and odontoblast-like cells extending processes into dentinal tubules, whereas dental pulp stem cell grafts formed less organized tissue and mineral deposits. MP-derived tissues also exhibited angiogenic potential, forming vessel-like structures containing pericytes and endothelial cells.

Conclusions

This preliminary in vivo mouse study suggests the feasibility of MP transplantation and its potential for dentin–pulp complex regeneration, though further studies are needed to assess long-term outcomes and clinical applicability.

牙髓干细胞（DPSCs）因其多能性和分化能力而被认为是牙本质-牙髓复合体再生的潜在来源。然而，基于细胞的方法需要酶消化和体外扩增，这可能会改变细胞特性并阻碍临床翻译。这项初步的原理验证研究在异位小鼠模型中使用新鲜碎髓（MP）作为再生牙髓学的潜在可翻译方法，研究了基于组织的替代方法。方法：将人牙髓组织切碎或酶解，植入I型胶原支架，插入根碎片，皮下植入免疫功能低下小鼠。结果：组织学显示，MP移植产生了组织良好的牙本质-牙髓样组织，具有高细胞性、高血管化、高矿化，成牙细胞样细胞延伸到牙本质小管，而DPSC移植形成的组织和矿物质沉积较少。mp来源的组织也表现出血管生成的潜力，形成血管样结构，包括周细胞和内皮细胞。结论：这项初步的小鼠体内研究表明MP移植的可行性及其在牙本质-牙髓复合体再生方面的潜力，尽管需要进一步的研究来评估长期结果和临床适用性。

{"title":"Immunohistological Characterization of Minced Dental Pulp Transplant in an Ectopic Mouse Model","authors":"Chaehwan Lee DDS, MS , Yuka Miyamoto DDS, PhD , Wei Chen PhD , Euiseong Kim DDS, MSD, PhD , Insoon Chang DDS, MS, PhD , Mo K. Kang DDS, PhD","doi":"10.1016/j.joen.2025.11.017","DOIUrl":"10.1016/j.joen.2025.11.017","url":null,"abstract":"<div><h3>Introduction</h3><div>Dental pulp stem cells have been explored as a potential source for dentin–pulp complex regeneration because of their pluripotency and differentiation capacity. However, cell-based approaches require enzymatic digestion and <em>in vitro</em> expansion, which may alter cell properties and hinder clinical translation. This preliminary proof-of-principle study examines a tissue-based alternative using freshly minced pulp (MP) in an ectopic mouse model as a potentially translatable approach for regenerative endodontics.</div></div><div><h3>Methods</h3><div>Human dental pulp tissue was either minced or enzymatically digested, seeded onto collagen type I scaffolds, inserted into root fragments, and implanted subcutaneously into immunocompromised mice.</div></div><div><h3>Results</h3><div>Histology revealed that MP grafting generated well-organized dentin–pulp–like tissue with high cellularity, vascularization, mineralization, and odontoblast-like cells extending processes into dentinal tubules, whereas dental pulp stem cell grafts formed less organized tissue and mineral deposits. MP-derived tissues also exhibited angiogenic potential, forming vessel-like structures containing pericytes and endothelial cells.</div></div><div><h3>Conclusions</h3><div>This preliminary <em>in vivo</em> mouse study suggests the feasibility of MP transplantation and its potential for dentin–pulp complex regeneration, though further studies are needed to assess long-term outcomes and clinical applicability.</div></div>","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":"52 3","pages":"Pages 405-413"},"PeriodicalIF":3.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145794150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Survival of Endodontically Treated Cracked Teeth: A 10- to 15-Year Retrospective Study 牙髓治疗后裂牙的存活率：一项10至15年的回顾性研究。

IF 3.6 2区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of endodontics

Pub Date : 2026-03-01 Epub Date: 2025-11-21 DOI: 10.1016/j.joen.2025.11.010

Pei Yuan Chan BDS, MDS, M Endo RCS, FAMS , Rachel Fangying Seet BDS, MDS , Seyed Ehsan Saffari PhD , Stella Jinran Zhan PhD , Nah Nah Chen BDS, MDS, MS, FAMS

Introduction

To investigate long-term (10- to 15-year) survival and success rates of endodontically treated cracked teeth and to identify possible prognostic factors related to their survival and success.

Methods

Patients who had endodontically treated cracked teeth were seen for a 10- to 15-year review. Preoperative and intraoperative treatment records were retrieved. Clinical and radiographic evaluations were performed. Two outcomes were investigated: survival (tooth present) and success (asymptomatic with complete radiographic healing). The 10- and 15-year tooth survival and success rate were estimated. Cox proportional hazards regression assessed the impact of various factors on the time to tooth extraction and time to complete healing.

Results

Data from 196 patients with 204 endodontically treated cracked teeth were analyzed. The 10- and 15-year survival rates were 66% (95% confidence interval [CI]: 60%-73%) and 55% (95% CI: 48%-63%), respectively. Success rates declined from 64% at 10 years to 37% at 15 years. Preoperative probing depth (PD) was the primary statistically significant factor for survival. Teeth with no preoperative PD (<4 mm) had higher survival rates of 76% at 10 years and 64% at 15 years. Multivariable analysis revealed significantly increased risk for teeth with PD of 4–5 mm (adjusted hazard ratio [aHR] = 2.48, 95% CI: 1.41-4.38, P = .002) and ≥6 mm (aHR = 3.19, 95% CI: 1.56-6.54, P = .002) for survival analysis. Older age was a modest independent risk factor (aHR = 1.03 per year, 95% CI: 1.00–1.05, P = .026) for survival.

Conclusions

Endodontic treatment of cracked teeth with favorable preoperative PDs demonstrates long-term survival comparable to noncracked teeth and is a viable long-term treatment option which should be recommended.

目的：探讨牙髓治疗后牙裂的长期（10 ~ 15年）存活率和成功率，并探讨影响牙髓治疗后牙裂存活率和成功率的可能因素。方法：对接受牙髓治疗的患者进行10 ~ 15年的回顾性分析。检索术前和术中治疗记录。进行临床和影像学评价。研究了两种结果：存活（牙齿存在）和成功（无症状且放射学完全愈合）。估计10年和15年的牙齿存活率和成功率。Cox比例风险回归评估各因素对拔牙时间和完全愈合时间的影响。结果：对196例髓内治疗的204颗牙的资料进行分析。10年和15年生存率分别为66% （95% CI: 60-73%）和55% （95% CI: 48-63%）。成功率从10年的64%下降到15年的37%。术前探查深度（PD）是影响生存率的主要因素。结论：牙髓治疗牙裂，术前探查深度良好，与非牙裂相比，牙髓治疗的长期存活率相当，是一种可行的长期治疗选择，值得推荐。

{"title":"Survival of Endodontically Treated Cracked Teeth: A 10- to 15-Year Retrospective Study","authors":"Pei Yuan Chan BDS, MDS, M Endo RCS, FAMS , Rachel Fangying Seet BDS, MDS , Seyed Ehsan Saffari PhD , Stella Jinran Zhan PhD , Nah Nah Chen BDS, MDS, MS, FAMS","doi":"10.1016/j.joen.2025.11.010","DOIUrl":"10.1016/j.joen.2025.11.010","url":null,"abstract":"<div><h3>Introduction</h3><div>To investigate long-term (10- to 15-year) survival and success rates of endodontically treated cracked teeth and to identify possible prognostic factors related to their survival and success.</div></div><div><h3>Methods</h3><div>Patients who had endodontically treated cracked teeth were seen for a 10- to 15-year review. Preoperative and intraoperative treatment records were retrieved. Clinical and radiographic evaluations were performed. Two outcomes were investigated: survival (tooth present) and success (asymptomatic with complete radiographic healing). The 10- and 15-year tooth survival and success rate were estimated. Cox proportional hazards regression assessed the impact of various factors on the time to tooth extraction and time to complete healing.</div></div><div><h3>Results</h3><div>Data from 196 patients with 204 endodontically treated cracked teeth were analyzed. The 10- and 15-year survival rates were 66% (95% confidence interval [CI]: 60%-73%) and 55% (95% CI: 48%-63%), respectively. Success rates declined from 64% at 10 years to 37% at 15 years. Preoperative probing depth (PD) was the primary statistically significant factor for survival. Teeth with no preoperative PD (<4 mm) had higher survival rates of 76% at 10 years and 64% at 15 years. Multivariable analysis revealed significantly increased risk for teeth with PD of 4–5 mm (adjusted hazard ratio [aHR] = 2.48, 95% CI: 1.41-4.38, <em>P</em> = .002) and ≥6 mm (aHR = 3.19, 95% CI: 1.56-6.54, <em>P</em> = .002) for survival analysis. Older age was a modest independent risk factor (aHR = 1.03 per year, 95% CI: 1.00–1.05, <em>P</em> = .026) for survival.</div></div><div><h3>Conclusions</h3><div>Endodontic treatment of cracked teeth with favorable preoperative PDs demonstrates long-term survival comparable to noncracked teeth and is a viable long-term treatment option which should be recommended.</div></div>","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":"52 3","pages":"Pages 376-386.e2"},"PeriodicalIF":3.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145587720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In Vitro and Ex Vivo Evaluation of a Novel Solvent for Tricalcium Silicate-based Sealers 一种新型硅酸三钙基密封剂溶剂的体外和体外评价。

IF 3.6 2区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of endodontics

Pub Date : 2026-03-01 Epub Date: 2025-11-19 DOI: 10.1016/j.joen.2025.11.009

David Colmenar DMD, MSD , Saaya Sakoda DDS , Tanguy Terlier PhD , Takashi Komabayashi DDS, MDS, PhD , Timothy Kirkpatrick DDS , Ji Wook Jeong DMD, MSD

Introduction

The need for removal of tricalcium silicate-based sealers in endodontic retreatment is increasing, but it is challenging due to their limited solubility. Therefore, new solvents are needed.

Methods

In vitro solubility assays of EndoSequence BC sealer (BC) were prepared and evaluated in 7 groups (n = 10): pH 4 buffer (B4), pH 6 buffer (B6), pH 7 deionized water (H₂O), pH 8.16 buffer B8, pH 10 buffer (B10), 17% ethylenediaminetetraacetic acid (EDTA), and pH 10 buffered 17% EDTA (E10). Ex vivo dentin disks were immersed in either B4 or E10, then the time-of-flight secondary ion mass spectrometry was used to quantify dentin decalcification. Extracted teeth were instrumented and obturated using a single cone technique with BC short of working length and the apical 2 mm filled only with sealer. Three groups (n = 11) of teeth were retreated by a single blinded operator with either H₂O, EDTA, or E10 until patency was obtained. Results were analyzed using two-way ANOVA with post hoc tests.

Results

Solubility values for each group were: B4, 48.6% ± 2.8; B6, 41.4% ± 4.6; H₂O, 13.5% ± 1.9; B8, 13.2% ± 3.2; B10, 11.4% ± 3.4; EDTA, 32.6% ± 6.4; and E10, 51.1% ± 4.7. BC was significantly more soluble in both B4 and E10 than in the other groups. There was no significant difference in solubility or dentin decalcification between B4 and E10. Patency rates and time to achieve patency did not differ significantly among all groups.

Conclusions

E10 is an effective solvent for BC during endodontic retreatment procedures but does not affect the ability to regain patency.

引言：在根管再治疗中，对硅酸三钙基密封剂的去除需求正在增加，但由于其溶解度有限，这是具有挑战性的。因此，需要新的溶剂。方法：采用pH 4缓冲液（B4）、pH 6缓冲液（B6）、pH 7去离子水（H2O）、pH 8.16缓冲液（B8）、pH 10缓冲液（B10）、17% EDTA （EDTA）、pH 10缓冲17% EDTA (E10) 7组（n=10）进行体外溶解度测定。将离体牙本质盘浸泡在B4或E10中，然后用ToF-SIMS定量牙本质脱钙。拔牙采用单锥体技术固定和封闭，BC短工作长度，根尖仅填充2 mm密封剂。三组（n=11）牙由单盲操作人员用H2O、EDTA或E10退牙，直至获得通畅。结果采用双因素方差分析和事后检验进行分析。结果：各组溶解度值分别为：B4, 48.6%±2.8；B6, 41.4%±4.6;水,13.5%±1.9;B8, 13.2%±3.2;B10, 11.4%±3.4;EDTA, 32.6%±6.4;E10为51.1%±4.7。BC在B4和E10中的可溶性明显高于其他组。B4和E10的溶解度和牙本质脱钙无显著差异。两组间通畅率和通畅时间无显著差异。结论：E10是根管再治疗过程中BC的有效溶剂，但不影响恢复通畅的能力。

{"title":"In Vitro and Ex Vivo Evaluation of a Novel Solvent for Tricalcium Silicate-based Sealers","authors":"David Colmenar DMD, MSD , Saaya Sakoda DDS , Tanguy Terlier PhD , Takashi Komabayashi DDS, MDS, PhD , Timothy Kirkpatrick DDS , Ji Wook Jeong DMD, MSD","doi":"10.1016/j.joen.2025.11.009","DOIUrl":"10.1016/j.joen.2025.11.009","url":null,"abstract":"<div><h3>Introduction</h3><div>The need for removal of tricalcium silicate-based sealers in endodontic retreatment is increasing, but it is challenging due to their limited solubility. Therefore, new solvents are needed.</div></div><div><h3>Methods</h3><div><em>In vitro</em> solubility assays of EndoSequence BC sealer (BC) were prepared and evaluated in 7 groups (<em>n</em> = 10): pH 4 buffer (B4), pH 6 buffer (B6), pH 7 deionized water (H<sub>2</sub>O), pH 8.16 buffer B8, pH 10 buffer (B10), 17% ethylenediaminetetraacetic acid (EDTA), and pH 10 buffered 17% EDTA (E10). <em>Ex vivo</em> dentin disks were immersed in either B4 or E10, then the time-of-flight secondary ion mass spectrometry was used to quantify dentin decalcification. Extracted teeth were instrumented and obturated using a single cone technique with BC short of working length and the apical 2 mm filled only with sealer. Three groups (<em>n</em> = 11) of teeth were retreated by a single blinded operator with either H<sub>2</sub>O, EDTA, or E10 until patency was obtained. Results were analyzed using two-way ANOVA with post hoc tests.</div></div><div><h3>Results</h3><div>Solubility values for each group were: B4, 48.6% ± 2.8; B6, 41.4% ± 4.6; H<sub>2</sub>O, 13.5% ± 1.9; B8, 13.2% ± 3.2; B10, 11.4% ± 3.4; EDTA, 32.6% ± 6.4; and E10, 51.1% ± 4.7. BC was significantly more soluble in both B4 and E10 than in the other groups. There was no significant difference in solubility or dentin decalcification between B4 and E10. Patency rates and time to achieve patency did not differ significantly among all groups.</div></div><div><h3>Conclusions</h3><div>E10 is an effective solvent for BC during endodontic retreatment procedures but does not affect the ability to regain patency.</div></div>","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":"52 3","pages":"Pages 436-441"},"PeriodicalIF":3.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145563984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

首页上一页

下一页尾页

类型

全部化学•材料生命科学医学物理工程技术环境•农林材料科学地球科学法学管理学化学环境科学与生态学计算机科学教育学经济学农林科学人文科学生物学数学物理与天体物理心理学综合性期刊其他工业工程理学历史学农学文学信息工程

数据库

全部 ACS Publications Elsevier ieeexplore Springer The Royal Society of Chemistry Wiley

期刊

Journal of endodontics

全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.

﹀