Journal of endodontics最新文献

{"title":"Allogeneic Mesenchymal Stromal Cells Transplantation Induces Arrest of External Apical Inflammatory Resorption in a Mature Nonvital Traumatized Tooth.","authors":"Jose Francisco Gomez-Sosa, Olga Wittig, Dylana Diaz-Solano, Jose E Cardier","doi":"10.1016/j.joen.2026.01.019","DOIUrl":"10.1016/j.joen.2026.01.019","url":null,"abstract":"<p><strong>Introduction: </strong>Mesenchymal stromal cells (MSCs) have been proposed for tissue regeneration based on their paracrine and immunomodulatory effects. Based on these features, MSCs may regulate inflammation and tissue repair. This case report assessed whether allogeneic bone marrow MSCs (BM-MSCs) can arrest external apical inflammatory resorption (EAIR) in a mature, nonvital traumatized tooth.</p><p><strong>Methods: </strong>A healthy 14-year-old male with intermittent edema and a sinus tract associated with tooth #9 was referred for endodontic evaluation. Radiographically, tooth #9 showed EAIR with a vertical/diagonal mesial pattern and a 3-mm periapical lesion with widened periodontal ligament space. The root canal was cleaned and shaped; calcium hydroxide was used as interappointment medication, and cryopreserved allogeneic BM-MSCs were thawed, expanded, incorporated into preclotted platelet-rich plasma, and implanted into the pulp cavity. The cervical third was sealed with bioceramic cement and composite.</p><p><strong>Results: </strong>Cryopreserved BM-MSCs retained fibroblast-like morphology, expressed CD73/CD90/CD105, and showed osteogenic, adipogenic, and chondrogenic differentiation. A BM-MSC/PRP clot was transplanted without complications or adverse events. At 3 months, radiographs showed reduction of the periapical radiolucency with initial bone formation and positive cold and electric pulp test responses. Between 12 and 24 months, reappearance of lamina dura, remodeling of the resorbed surface, and complete radiographic healing with arrest of EAIR were observed. At 48 months, tooth #9 was asymptomatic, responsive to cold and electric pulp test, and showed normal periapical architecture and mineralized tissue within the canal with an apical constriction.</p><p><strong>Conclusions: </strong>BM-MSC transplantation may arrest EAIR and promote pulp-like and periapical tissue regeneration.</p>","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2026-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146119172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retreatment of Bioceramic Sealers Using a Novel Solvent: Dissolution, Patency, and Dentinal Effects","authors":"Jemma Hanson DMD ,&nbsp;Michelle Wu ,&nbsp;Ajay Shakya PhD ,&nbsp;Ryan Walsh DDS, MS ,&nbsp;Poorya Jalali DDS","doi":"10.1016/j.joen.2025.10.012","DOIUrl":"10.1016/j.joen.2025.10.012","url":null,"abstract":"<div><h3>Introduction</h3><div>This study evaluated the effectiveness of Endo Sealer Solvent (ESS), 5.25% sodium hypochlorite (NaOCl), 17% ethylenediaminetetraacetic acid (EDTA), and chloroform (CHCl₃) in facilitating patency in canals obturated with bioceramic sealer and assessed their effects on dentin.</div></div><div><h3>Methods</h3><div>The study had 3 parts. First, 60 disk-shaped specimens of EndoSequence BC Sealer (BC) were immersed in one of the 4 irrigants for 3 hours and percent weight loss was calculated. Second, 60 single-canal teeth were obturated with 3 mm of BC in the apical third; after 1 week, gutta-percha was removed and the time required to regain apical patency with a 10 C-file using the respective solvent was measured. Third, 8 additional teeth were irrigated with the solutions and evaluated under scanning electron microscopy for dentinal changes. Kruskal-Wallis and Mann-Whitney tests were used for analysis.</div></div><div><h3>Results</h3><div>ESS and EDTA dissolved the greatest amount of BC, with no significant difference between them (<em>P</em> &gt; .05), but both were significantly more effective than NaOCL and CHCl₃ (<em>P</em> &lt; .001). Regardless of the irrigant used, patency was achieved in all teeth with no significant difference in time (<em>P</em> &gt; .05). Scanning electron microscopy showed no erosion in any group; ESS and EDTA removed the smear layer, while NaOCL and CHCl₃ did not.</div></div><div><h3>Conclusions</h3><div>ESS and EDTA were the most effective in dissolving BC while preserving dentin, but all irrigants allowed 100% patency with no significant time difference, indicating solvent selection does not influence clinical patency outcomes.</div></div>","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":"52 2","pages":"Pages 279-284"},"PeriodicalIF":3.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146037149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of Factors Affecting the Accuracy of Static-guided Endodontics","authors":"Cheng Chen MD ,&nbsp;Diya Leng MD ,&nbsp;Tao Wu MD ,&nbsp;Lili Chen MD ,&nbsp;Tingting Zhu MD ,&nbsp;Mingrui Dai MD ,&nbsp;Yuting Wu MD ,&nbsp;Tianyin Zhao MD ,&nbsp;Ya Tang MD ,&nbsp;Daming Wu PhD","doi":"10.1016/j.joen.2025.10.010","DOIUrl":"10.1016/j.joen.2025.10.010","url":null,"abstract":"<div><h3>Introduction</h3><div>To evaluate how template type, sleeve height, revolutions per minute (RPM), tooth type, drilling distance, and drill diameter affect the accuracy of static-guided endodontics.</div></div><div><h3>Methods</h3><div>In this <em>in vitro</em> study, 113 isolated premolars and molars collected from the oral surgery clinic and 10 three-dimensional printed resin teeth were mounted in a standard dental mold in their corresponding tooth positions. Cone-beam computed tomography and optical scans were obtained and co-registered. Templates were designed, and deviations were measured using Implant Studio (3Shape Unite, 3shape, Copenhagen, Denmark).</div></div><div><h3>Results</h3><div>The angular deviation of the resin template (without metal sleeve) was higher than that of the metal template (<em>P</em> &lt; .05). The apical linear deviation of the resin template (without metal sleeve) was significantly higher than that of the resin template (with metal sleeve) (<em>P</em> &lt; .05). The coronal linear deviation of the metal template was higher than that of the resin template (with metal sleeve) (<em>P</em> &lt; .05).The apical linear deviation of the resin template with 4-mm height sleeve was higher than that of the 6-mm and 8-mm height sleeves (<em>P</em> &lt; .05), and there was no significant difference between the 6-mm and 8-mm height sleeves. Drill diameter, RPM, and tooth type (resin or isolated teeth) did not affect the accuracy of static guided endodontics.</div></div><div><h3>Conclusions</h3><div>The apical linear deviation increased with drilling distance. Resin templates (without metal sleeves) are not recommended. The accuracy of static-guided endodontics was not affected by drill diameter, RPM, or tooth type (resin or isolated teeth).</div></div>","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":"52 2","pages":"Pages 270-278"},"PeriodicalIF":3.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145512991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cemental Tear: Systematic Review and Thematic Analysis of Clinical and Imaging Features with a Proposed Diagnostic Framework","authors":"José Evando da Silva-Filho DDS ,&nbsp;Aryanna Celly Rodrigues-Lima DDS ,&nbsp;Kayo Lúcio Silveira-Fernandes ,&nbsp;Camille de Sousa Veloso DDS ,&nbsp;João Paulo Viana Braga DDS, MSD ,&nbsp;Sandra Régia Albuquerque Ximenes DDS, MSD ,&nbsp;Elilton Cavalcante Pinheiro-Júnior DDS, MSD, PhD ,&nbsp;Danielle Frota de Albuquerque DDS, MSc, PhD ,&nbsp;Eduardo Diogo Gurgel-Filho DDS, MSD, PhD","doi":"10.1016/j.joen.2025.10.004","DOIUrl":"10.1016/j.joen.2025.10.004","url":null,"abstract":"<div><h3>Introduction</h3><div>Cemental tear (CT) is a rare condition with poorly understood prevalence, etiology, and clinical presentation, often mimicking vertical root fractures or endodontic-periodontal lesions. This review aimed to synthesize current evidence on CT and propose a diagnostic framework.</div></div><div><h3>Methods</h3><div>A comprehensive search was conducted in Cochrane Library, Latin American and Caribbean Health Sciences Literature, PubMed, ScienceDirect, Scopus, Web of Science, and grey literature (Google Scholar, ProQuest) for case reports (2000–2024). Inclusion required full clinical and radiographic documentation. Risk of bias was assessed using the Joanna Briggs Institute checklist. Data on epidemiological, clinical, and imaging features were extracted.</div></div><div><h3>Results</h3><div>Twenty studies reported 24 patients and 39 teeth. Methodological quality was heterogeneous, mostly with moderate risk of bias. CT mainly affected single-rooted teeth, especially incisors (46.1%), in older patients (mean 56.2 years). Frequent clinical findings included deep periodontal pockets (75%), mobility (60%), and fistulas (40%). Radiographically, bone loss (33.3%), radiopaque fragments (28.2%), and lateral radiolucencies (23.1%) were noted. Cone-beam computed tomography proved crucial for detecting buccal/lingual fragments. Histopathology confirmed cementum detachment, often infection-related. Treatments ranged from fragment removal to extraction, with prognosis linked to early diagnosis.</div></div><div><h3>Conclusions</h3><div>CT is rare and challenging, best identified with high-resolution cone-beam computed tomography and integrated clinical evaluation. Early, precise diagnosis guides prognosis, with conservative fragment removal recommended when feasible.</div></div>","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":"52 2","pages":"Pages 202-211"},"PeriodicalIF":3.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145301387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intracellular Bacteria in Stem Cells of the Apical Papilla: A “Trojan Horse” for Regenerative Endodontic Failure","authors":"Shanthini Kalimuthu MSc, PhD ,&nbsp;Prasanna Neelakantan MDS, PhD","doi":"10.1016/j.joen.2025.10.007","DOIUrl":"10.1016/j.joen.2025.10.007","url":null,"abstract":"<div><h3>Introduction</h3><div>Regenerative endodontic procedures show unpredictable outcomes in infected teeth due to persistent infection. While current disinfection protocols reduce but do not eliminate root canal bacteria, the fate of residual microorganisms during stem cell recruitment remains unclear. This study tested the hypothesis that endodontic pathogens invade and survive within stem cells of the apical papilla (SCAP), diminishing its biomineralization potential.</div></div><div><h3>Methods</h3><div>Internalization of SCAP by Gram-positive (<em>Enterococcus faecalis, Actinomyces naeslundii</em>) and Gram-negative (<em>Porphyromonas gingivalis</em>, <em>Fusobacterium nucleatum</em>) bacteria was characterized using colony-forming unit assays, confocal microscopy and flow cytometry. Intracellular survival of <em>E. faecalis</em> was monitored for 14 days in both planktonic and biofilm phases. The impact of intracellular <em>E. faecalis</em> on SCAP biomineralization and odontogenic differentiation was assessed using alkaline phosphatase activity, alizarin red staining, and quantitative real-time PCR. Statistical analyses were performed using one-way ANOVA with Dunnett's multiple comparison test or two-way ANOVA with Tukey's multiple comparison test. <em>P</em> &lt; .05 was considered statistically significant.</div></div><div><h3>Results</h3><div>All tested bacteria invaded SCAP with differential efficiencies. <em>E. faecalis</em> and <em>F. nucleatum</em> demonstrated robust internalization (∼5-log colony forming unit), while <em>P. gingivalis</em> and <em>A. naeslundii</em> showed reduced invasion (∼2.5 log colony forming unit). <em>E. faecalis</em> persisted intracellularly for up to 14 days, with biofilm-phase bacteria showing enhanced survival in monolayer SCAP cultures. Intracellular <em>E. faecalis</em> abrogated SCAP mineralization while maintaining cell viability, accompanied by significant downregulation of all tested odontogenic genes (<em>P</em> &lt; .05).</div></div><div><h3>Conclusions</h3><div>Bacteria invade and establish persistent intracellular infections within SCAP, creating protected reservoirs. These intracellular bacteria severely compromise odontogenic differentiation without killing the host cells, representing a potentially unrecognized mechanism of regenerative endodontic procedure failure. This \"Trojan horse\" strategy may explain the unpredictable outcomes of regenerative endodontics in infected teeth.</div></div>","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":"52 2","pages":"Pages 253-260"},"PeriodicalIF":3.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145355013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Top 100 Most-cited Articles in Root Canal Anatomy: A Scopus-based Bibliometric Study","authors":"Yu-Chiao Wu DDS, DMSc ,&nbsp;Ho-Sheng Chiang DDS, DMSc ,&nbsp;Zi-Jun Dai DDS ,&nbsp;Yi-Jie Chen DDS ,&nbsp;Yen-Ching Chao DDS ,&nbsp;Hsiao-Wen Yeh DDS ,&nbsp;Ren-Yeong Huang DDS, PhD ,&nbsp;Yi-Shing Shieh DDS, PhD","doi":"10.1016/j.joen.2025.09.010","DOIUrl":"10.1016/j.joen.2025.09.010","url":null,"abstract":"<div><h3>Introduction</h3><div>Understanding root canal anatomy is fundamental for successful endodontic treatment. This bibliometric study aimed to identify and analyze the 100 most-cited articles related to root canal morphology to discover research trends, influential publications, and methodological progress in the field.</div></div><div><h3>Methods</h3><div>Data were extracted from the Scopus database using the search terms “root canal anatomy” OR “root canal morphology” AND NOT “Preparation,” with selection finalized on July 28, 2025. Articles were manually screened, and only English-language original research related to human teeth was included. Citation counts, publication years, journal names, countries of origin, study designs, and methodologies were analyzed.</div></div><div><h3>Results</h3><div>Most of the top-cited studies were published in the Journal of Endodontics and International Endodontic Journal, which together contributed 80% of the articles. Cone-beam computed tomography was the most used method, followed by dye-injected decalcified teeth and micro-computed tomography. The most frequently studied teeth were mandibular and maxillary first molars. Geographically, the United States, Brazil, and China led in publication output. Notably, there were no articles from Africa, highlighting a potential area for collaborative development. Over time, research has shifted from invasive <em>in vitro</em> techniques to advanced non-invasive imaging. The most-cited article was Vertucci's 1984 classification study, which remains widely used today.</div></div><div><h3>Conclusions</h3><div>This bibliometric analysis delivers a comprehensive overview of influential studies in root canal anatomy, offering insights into global research patterns and technological advancement.</div></div>","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":"52 2","pages":"Pages 181-191"},"PeriodicalIF":3.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145149249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and Laboratory Insights Into the GentleWave System: A Scoping Review","authors":"Lucas Peixoto de Araújo DDS, MS, PhD ,&nbsp;Bruna Cavalcante Chaves de Araújo DDS ,&nbsp;Felipe Immich DDS, PhD ,&nbsp;Bruno das Neves Cavalcanti DDS, MS, PhD ,&nbsp;Neville J. McDonald DDS, MS","doi":"10.1016/j.joen.2025.10.014","DOIUrl":"10.1016/j.joen.2025.10.014","url":null,"abstract":"<div><h3>Introduction</h3><div>The GentleWave System is an advanced endodontic irrigation technology that utilizes multisonic energy and optimized fluid dynamics to improve root canal cleaning and disinfection. While early studies report encouraging outcomes, its comparative clinical effectiveness, long-term benefits, and cost-efficiency remain under investigation. This scoping review aims to systematically assess the available clinical and laboratory evidence on the GentleWave System in endodontics.</div></div><div><h3>Methods</h3><div>This review was conducted in accordance with Preferred Reporting Items for Systematic Review and Meta-analysis Extension for Scoping Reviews guidelines and was prospectively registered in the Open Science Framework. A comprehensive search of 5 electronic databases (Cochrane Library, EMBASE, PubMed/MEDLINE, SciVerse Scopus, and Web of Science) was performed to identify clinical and <em>in vitro</em> studies evaluating the GentleWave System.</div></div><div><h3>Results</h3><div>A total of 34 studies met the inclusion criteria, including 28 laboratory-based investigations (82.4%) and 6 clinical studies (17.6%). Clinical trials reported high periapical healing rates, exceeding 97% at 6- and 12-month follow-ups, and postoperative pain levels comparable to passive ultrasonic irrigation. However, recent prospective data indicate similar healing outcomes when compared to other advanced irrigation techniques. Laboratory studies consistently demonstrated significant performance in removing biofilm, smear layer, calcium hydroxide, and filling materials, while maintaining reduced apical pressure and minimal dentin erosion. Methodological variability and limited long-term clinical data remain key limitations.</div></div><div><h3>Conclusions</h3><div>The GentleWave System shows potential as an adjunctive irrigation technology, particularly in anatomically complex cases. Overall, the evidence mapped in this scoping review appears low to moderate, reflecting the limited number of available clinical studies and their high risk of bias.</div></div>","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":"52 2","pages":"Pages 212-226"},"PeriodicalIF":3.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145409183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hospital-Based Emergency Department Visits due to Periapical Abscess in the United States: Nationwide Estimates for the Years 2021–2022","authors":"Sofie Vogel BS ,&nbsp;Gloria Ahn DDS ,&nbsp;Romesh Nalliah DDS, MHCM ,&nbsp;Maysaa Oubaidin DDS, MS ,&nbsp;Michael D. Han DDS ,&nbsp;Mohammed H. Elnagar DDS, MS, PhD ,&nbsp;Veerasathpurush Allareddy BDS, MBA, MHA, MMSc, PhD ,&nbsp;Min Kyeong Lee DMD, DMSc","doi":"10.1016/j.joen.2025.10.011","DOIUrl":"10.1016/j.joen.2025.10.011","url":null,"abstract":"<div><h3>Introduction</h3><div>Periapical abscess (PA) is an odontogenic infection that primarily arises from pulpal disease and can lead to life-threatening conditions if left untreated. The objective of this study was to provide updated national estimates on the prevalence of PA in the United States hospital-based emergency departments (EDs) for the years 2021–2022, and to analyze predictors of related hospital charges.</div></div><div><h3>Methods</h3><div>The Nationwide Emergency Department Sample database was used for the years 2021–2022. All ED visits with a primary diagnosis of PA were selected for analysis of the frequency of visits, sociodemographic, and hospital-related data. A multivariable linear regression analysis model was used to identify predictor variables that influence ED and hospital charges.</div></div><div><h3>Results</h3><div>During the years 2021 and 2022 in the United States, a total of 846,629 ED visits were attributed to a primary diagnosis of PA. The populations who frequented the ED for PA the most were more likely to be insured by Medicaid (44.2%) and reside in low-income areas (42.1%). The mean ED hospital charge was $2,585 per encounter. Age, sex, ethnicity, insurance status, household income levels, geographic location, hospital teaching status, and presence of comorbid conditions all had a significant impact on influencing hospital charges (<em>P</em> &lt; .05).</div></div><div><h3>Conclusions</h3><div>The study found that the frequency of visits for PA in the ED remains high, and the hospital ED charges have increased significantly despite similar outcomes compared to data from the past decade. Demographic, socioeconomic, hospital-related, and comorbid medical conditions were associated with hospital charges.</div></div>","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":"52 2","pages":"Pages 245-252.e1"},"PeriodicalIF":3.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145400888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Insights Into the February 2026 Issue of the JOE","authors":"Anita Aminoshariae DDS, MS,&nbsp;Amir Azarpazhooh DDS, MSc, PhD, FRCD(C),&nbsp;Gerald N. Glickman DDS, MS, MBA, JD,&nbsp;Jianing He DMD, PhD,&nbsp;Sahng G. Kim DDS, MS,&nbsp;Anil Kishen BDS, MDS, PhD,&nbsp;Ariadne M. Letra DDS, MS, PhD,&nbsp;Linda Levin DDS, PhD,&nbsp;Ronald Ordinola-Zapata,&nbsp;Frank C. Setzer DMD, PhD, MS,&nbsp;Franklin R. Tay BDSc(Hons), PhD,&nbsp;Kenneth M. Hargreaves DDS, PhD","doi":"10.1016/j.joen.2025.12.007","DOIUrl":"10.1016/j.joen.2025.12.007","url":null,"abstract":"","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":"52 2","pages":"Pages 163-165"},"PeriodicalIF":3.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146037294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tricalcium Silicate Endodontic Cements: A Bibliometric Analysis of the 100 Most Cited Articles","authors":"Betânia de Lourdes Canal Vasconcellos DDS ,&nbsp;Luna Chagas Clementino DDS ,&nbsp;Thiago César da Silva Lima DDS ,&nbsp;Caroline Andrade Maia DDS ,&nbsp;Gabriele Andrade-Maia DDS ,&nbsp;Paulo Antônio Martins-Júnior PhD ,&nbsp;Francine Benetti PhD ,&nbsp;Warley Luciano Fonseca Tavares PhD","doi":"10.1016/j.joen.2025.09.017","DOIUrl":"10.1016/j.joen.2025.09.017","url":null,"abstract":"<div><h3>Introduction</h3><div>Bibliometric analysis is an indicator of high-quality evidence for the decision-making process regarding the use of biomaterials. The aim of this study was to analyze the characteristics of the 100 most cited articles on tricalcium silicate endodontic cements.</div></div><div><h3>Methods</h3><div>A broad search strategy using key terms related to hydraulic endodontic cement was conducted in the Web of Science – Core Collection (WoS-CC) on May 30, 2025. Data were retrieved and organized in descending order of the number of citations in the WoS-CC, and each article was compared with the number of citations in the Scopus and Google Scholar databases. VOSviewer software (Leiden University, The Netherlands) was used to construct co-authorship networks. Spearman's correlations were performed using the Statistical Package for Social Sciences (SPSS 22.0, Armonk, NY).</div></div><div><h3>Results</h3><div>The most cited article was “Physical and chemical properties of a new root-end filling material,” by Torabinejad et al. (1995), with 821 citations in WoS-CC. Of the 100 articles, the corresponding authors were predominantly from the United States (<em>n</em> = 37). The institution of origin of most articles was Loma Linda University (USA) (<em>n</em> = 15). Experimental laboratory studies were the most common study design among the included articles (58%), followed by literature reviews (14%) and observational studies (11%). The mineral trioxide aggregate (MTA), whether ProRoot MTA or MTA Angelus, was the predominant studied material (21,84%) and most studies focused on the evaluation of material properties (48%).</div></div><div><h3>Conclusions</h3><div>This list of the most cited articles can provide a reference point to guide research and biomaterial selection.</div></div>","PeriodicalId":15703,"journal":{"name":"Journal of endodontics","volume":"52 2","pages":"Pages 192-201"},"PeriodicalIF":3.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145258346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}