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Use of statement validity analysis in minors alleging sexual assault: A systematic review 在未成年人性侵犯指控中使用陈述有效性分析:系统回顾。
IF 1.5 4区 医学 Q2 MEDICINE, LEGAL Pub Date : 2024-08-23 DOI: 10.1111/1556-4029.15604
Emilie Wouters MSc, Lauriane Constanty MSc, Sébastien Urben PhD, Joëlle Rosselet Amoussou Master IS, Jacques Gasser PhD

This systematic review aims to report on the use of Statement Validity Analysis (SVA) with minors involved in criminal justice proceedings. We conducted a literature search of six bibliographic databases up to March 2024. Additional searches were performed using citation tracing strategies. Nineteen studies published between 1991 and 2023 were retained. Most were published between 1991 and 2000, mainly in the USA. A scientific gap was observed for 10 years before studies resumed between 2011 and 2022. These 19 studies involved 2931 children; most were girls (n = 2080; 71%). The mean age was 9.4 years (SD = 2.40; min = 2; max = 17.5). Most studies did not mention the nature of the relationship between the child and the alleged perpetrator of sexual violence, three studies involved intra-family violence and six studies involved victims of intra- and extra-family violence. Nearly 75% of the interviewers were trained with SVA methods. Most were mental health professionals (52.6%) or police officers (15.8%). No study used the SVA as a whole, 10 studies used 19 criteria of the Criteria-Based Content Analysis (CBCA), and no study used the Validity Check List (VCL). Most studies performed SVA on interview transcripts (n = 8), and two studies performed their analysis on both verbatims and video. The conclusion of our literature review highlights the methodological weaknesses of these studies and encourages more research about the use of SVA in the judicial field to reduce the risk of misleading the judiciary.

本系统综述旨在报告陈述有效性分析(SVA)在刑事司法程序中对未成年人的使用情况。我们对截至 2024 年 3 月的六个文献数据库进行了文献检索。此外,我们还使用引文追踪策略进行了其他检索。我们保留了 19 项在 1991 年至 2023 年间发表的研究。大部分研究发表于 1991 年至 2000 年之间,主要集中在美国。在 2011 年至 2022 年期间恢复研究之前,出现了长达 10 年的科学空白期。这 19 项研究涉及 2931 名儿童,其中大多数是女孩(n = 2080;71%)。平均年龄为 9.4 岁(SD = 2.40;最小 = 2;最大 = 17.5)。大多数研究未提及儿童与被指控的性暴力实施者之间的关系性质,3 项研究涉及家庭内部暴力,6 项研究涉及家庭内部和家庭外部暴力的受害者。近 75% 的访谈者接受过关于 SVA 方法的培训。大多数是心理健康专业人员(52.6%)或警官(15.8%)。没有一项研究使用了整体 SVA,10 项研究使用了基于标准的内容分析 (CBCA) 的 19 项标准,没有一项研究使用了有效性检查表 (VCL)。大多数研究对访谈记录(n = 8)进行了 SVA 分析,有两项研究对逐字记录和视频进行了分析。我们文献综述的结论强调了这些研究在方法上的不足,并鼓励在司法领域使用 SVA 进行更多研究,以降低误导司法机构的风险。
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引用次数: 0
Combined interpretation of objective firearm evidence comparison algorithms using Bayesian networks 利用贝叶斯网络综合解释客观火器证据比较算法。
IF 1.5 4区 医学 Q2 MEDICINE, LEGAL Pub Date : 2024-08-22 DOI: 10.1111/1556-4029.15606
Jamie S. Spaulding PhD, Lauren S. LaCasse BA

Traditionally, firearm and toolmark examiners manually evaluate the similarity of features on two bullets using comparison microscopy. Advances in microscopy have made it possible to collect 3D topographic data, and several automated comparison algorithms have been introduced for the comparison of bullet striae using these data. In this study, open-source approaches for cross-correlation, congruent matching profile segments, consecutive matching striations, and a random forest model were evaluated. A statistical characterization of these automated approaches was performed using four datasets of consecutively manufactured firearms to provide a challenging comparison scenario. Each automated approach was applied to all samples in a pairwise fashion, and classification performance was compared. Based on these findings, a Bayesian network was empirically learned and constructed to leverage the strengths of each individual approach, model the relationship between the automated results, and combine them into a posterior probability for the given comparison. The network was evaluated similarly to the automated approaches, and the results were compared. The developed Bayesian network classified 99.6% of the samples correctly, and the resultant probability distributions were significantly separated more so than the automated approaches when used in isolation.

传统上,枪支和工具印记检验人员使用显微镜对比法手动评估两颗子弹上特征的相似性。显微镜技术的进步使三维地形数据的收集成为可能,并引入了几种自动比对算法,利用这些数据对子弹条纹进行比对。本研究评估了交叉相关、同向匹配剖面片段、连续匹配条纹和随机森林模型的开源方法。使用四个连续制造的枪支数据集对这些自动方法进行了统计鉴定,以提供一个具有挑战性的比较场景。每种自动方法都以成对方式应用于所有样本,并对分类性能进行比较。基于这些发现,我们根据经验学习并构建了一个贝叶斯网络,以利用每种方法的优势,建立自动结果之间关系的模型,并将它们组合成给定比较的后验概率。对该网络的评估与自动方法类似,并对结果进行了比较。所开发的贝叶斯网络对 99.6% 的样本进行了正确分类,所得出的概率分布比单独使用的自动方法有明显的分离。
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引用次数: 0
Application of the Agilent 2100 Bioanalyzer instrument as quality control for next-generation sequencing 将安捷伦 2100 生物分析仪应用于下一代测序的质量控制。
IF 1.5 4区 医学 Q2 MEDICINE, LEGAL Pub Date : 2024-08-21 DOI: 10.1111/1556-4029.15601
Alina Senst PhD, Hannah Bonsiepe MSc, Sarah Kron, Iris Schulz PhD

Next-generation sequencing (NGS) technologies have expanded the spectrum of forensic DNA analysis by facilitating efficient and precise genotyping of a large number of genetic markers. Yet, challenges persist regarding complex sample processing and assurance of equal molar concentrations across pooled samples. Since optimal cluster density is crucial for sequencing performance, the determination of both quantity and quality is indispensable for library preparation. In this study, we investigated the application of the Agilent 2100 Bioanalyzer for library quality control, as studies for forensic approaches, particularly for highly degraded postmortem samples, are rare. Our analysis encompassed assessing total DNA concentrations, fluorescence unit (FU) values, and adapter dimer concentrations in purified DNA libraries derived from buccal swabs and tissue samples of decomposed corpses. The sensitivity study tested a serial dilution derived from buccal swabs and revealed a decrease in FU values and an increase in adapter dimers with declining DNA input concentrations. Deviations in total DNA concentrations and average peak heights between the Agilent 2100 Bioanalyzer runs indicated a lack of repeatability in data and presented challenges in accurate quantification, which was also observed in previous studies. Yet, the analysis of degraded samples from decomposed human remains has shown the ability to detect adapter dimer concentrations, which can be crucial for the quality of subsequent NGS library preparation and sequencing success. Therefore, the Agilent 2100 Bioanalyzer proves to be a valuable tool for NGS quality control.

下一代测序(NGS)技术可对大量遗传标记进行高效、精确的基因分型,从而扩大了法医 DNA 分析的范围。然而,在复杂的样本处理和确保集合样本的等摩尔浓度方面仍存在挑战。由于最佳簇密度对测序性能至关重要,因此确定簇的数量和质量对文库制备不可或缺。在本研究中,我们调查了 Agilent 2100 生物分析仪在文库质量控制中的应用,因为法医方法的研究,尤其是针对高度降解的死后样本的研究并不多见。我们的分析包括评估总 DNA 浓度、荧光单位 (FU) 值和来自口腔拭子和腐烂尸体组织样本的纯化 DNA 文库中的适配二聚体浓度。灵敏度研究测试了从口腔拭子中提取的序列稀释液,结果显示,随着 DNA 输入浓度的降低,FU 值下降,适配器二聚体增加。安捷伦 2100 生物分析仪运行之间总 DNA 浓度和平均峰高的偏差表明数据缺乏可重复性,给精确定量带来了挑战,这在之前的研究中也有观察到。然而,对分解人类遗骸中降解样本的分析表明,有能力检测适配器二聚体的浓度,这对后续 NGS 文库制备的质量和测序的成功至关重要。因此,安捷伦 2100 生物分析仪被证明是 NGS 质量控制的重要工具。
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引用次数: 0
Commentary on: Downing NR, Scafide KN, Ali Z, Hayat MJ. Visibility of inflicted bruises by alternate light: Results of a randomized controlled trial. J Forensic Sci. 2024;69(3):880–7. https://doi.org/10.1111/1556-4029.15481 评论: Downing NR, Scafide KN, Ali Z, Hayat MJ:Downing NR、Scafide KN、Ali Z、Hayat MJ。交替光照下瘀伤的可见度:随机对照试验的结果。J Forensic Sci. 2024;69(3):880-7. https://doi.org/10.1111/1556-4029.15481.
IF 1.5 4区 医学 Q2 MEDICINE, LEGAL Pub Date : 2024-08-16 DOI: 10.1111/1556-4029.15599
William Hauda II MD, Sue Rotolo PhD, RN, Ralph Riviello MD, W. Anthony Gerard MD
<p>We read with interest the article by Downing NR, et al. regarding the use of alternate light to view bruises [<span>1</span>]. We agree with the authors that the identification of injuries in patients who have experienced physical violence is important. As colleagues who are forensic medicine experts, we recognize the importance of visualizing bruises in cases of interpersonal violence, especially in individuals with darkly pigmented skin, so we applaud your research on this issue. Practitioners need to be as accurate as possible in their evaluation. The use of tools to assist in the identification of injuries can be very helpful. We also recognize that forensic sciences and the associated analysis or evaluation must remain accurate and valid and not utilize “presumptive tests without confirmation” or tests lacking “reliability, reproducibility, repeatability, and replicability” [<span>2, 3</span>].</p><p>When reading this article, we were struck by the remarkable similarity in methods with previous publications by these authors on this topic [<span>4, 5</span>]. All three studies have the same number of 157 participants. This study and the study published in 2020 describe the same methodology of “quota sampling” to “recruit equal numbers of healthy participants.” The study published in 2022, however, stated that “a convenience sample of 157 subjects” was obtained. If these studies are of the same participants, then the statement in the 2022 publication about how the participants were recruited appears to be incorrect and potentially misleading. We are concerned that multiple studies analyzing the same data set create an improper opportunity for bias and post hoc analysis error.</p><p>The authors found in a previous analysis of the participants that both the 415 nm ALS with a yellow filter and the 450 nm ALS with a yellow filter to be “optimal for detecting evidence of bruising on individuals with known trauma” [<span>5</span>]. This was also apparent from table 5 of their 2020 study with the same data [<span>4</span>]. With this current publication, the authors state “only 415nm viewed through a yellow filter resulted in a clinically meaningful improvement (0.46 points) in visibility rating when compared to white light.” [<span>1</span>] In figure 1, of this study, we find it difficult to visually discern any difference between the various light frequencies used in very light skin or very dark skin. Additionally, we noted that all modalities of light had reduced visualization of bruises; no modality was clearly better in most or all skin color categories.</p><p>Reviewing table 2 in this recent paper shows that the 450 nm ALS with the yellow filter did not have as high a visibility rating improvement, but it was the only other assessment with a visibility rating improvement above 0.2. How should the reader discern what a clinically meaningful improvement in the visibility score would be?</p><p>Based upon the methods described by the authors, t
我们饶有兴趣地阅读了 Downing NR 等人撰写的关于使用交替光观察瘀伤的文章[1]。我们同意作者的观点,即对遭受身体暴力的患者进行伤痕鉴定非常重要。作为法医专家的同事,我们认识到在人际暴力案件中观察瘀伤的重要性,尤其是对于皮肤色素较深的人,因此我们对你们在这一问题上的研究表示赞赏。从业人员需要尽可能准确地进行评估。使用工具来帮助识别伤害是非常有帮助的。我们也认识到,法医学及相关分析或评估必须保持准确性和有效性,不能使用 "未经确认的推定测试 "或缺乏 "可靠性、再现性、可重复性和可复制性 "的测试[2, 3]。三项研究都有相同数量的 157 名参与者。这项研究和 2020 年发表的研究采用了相同的 "配额抽样 "方法,以 "招募同等数量的健康参与者"。然而,2022 年发表的研究报告称,"获得了 157 名受试者的方便样本"。如果这些研究的受试者相同,那么 2022 年发表的研究中关于如何招募受试者的陈述似乎是不正确的,并可能具有误导性。我们担心的是,对同一数据集进行分析的多项研究会造成偏差和事后分析错误。作者在之前对参与者的分析中发现,415 nm ALS(带黄色滤光片)和 450 nm ALS(带黄色滤光片)都是 "检测已知创伤个体瘀伤证据的最佳选择"[5]。这一点在他们 2020 年使用相同数据进行的研究表 5 中也很明显[4]。在目前发表的这篇论文中,作者指出 "与白光相比,只有通过黄色滤光片观察的 415nm 才会在能见度评分方面带来有临床意义的改进(0.46 分)"[1]。[1] 在这项研究的图 1 中,我们发现很难从视觉上分辨出在皮肤很白或很黑的人身上使用的各种光频之间有什么区别。此外,我们还注意到,所有光照模式对瘀伤的可视度都有所降低;在大多数或所有肤色类别中,没有一种模式的可视度明显更好。查看最近这篇论文中的表 2 可以发现,使用黄色滤光片的 450 nm ALS 的可视度提高幅度没有那么高,但它是唯一一种可视度提高幅度超过 0.2 的其他评估方法。根据作者描述的方法,他们使用 1 到 5 的视觉模拟量表,在 1、3 和 5 处定义了标签,从而构建了新的瘀伤可见度评分和吸收可见度评分。作者在文章中没有讨论他们是如何确定这一工具的可靠性、有效性或准确性的。在他们的方法中,他们没有说明在进行分析之前,他们认为量表改善的程度会构成有临床意义的改善。作者是如何选择 0.50 这个值的?读者无法从他们发表的文章中得知。使用该值后,作者似乎得出结论认为,评分提高 12.5% 即为 "有临床意义的改善"。他们认为在从 1 到 5 的量表中,0.50 分的变化具有临床意义,这代表了 12.5% 的变化,因为 0.5 是量表长度的八分之一。根据作者计算的实际值(0.46),这似乎是一个实际的 11.5% 的变化,而且根据作者自己的声明,这一结果只是 "接近有临床意义的增加",但并没有等于或超过它。因为没有其他作者或研究使用过 "瘀伤可见度评分 "或 "吸收可见度评分";为了进行比较,我们建议使用其他量表进行类比,以解释什么是有临床意义的改善。在医学文献中,视觉模拟疼痛评分和量表的研究历史悠久[6]。对于视觉模拟疼痛量表,不同作者公布的最小临床意义差异约为 10-20 mm [7,8]。这些数值代表了应被视为具有临床意义差异的最小值。在本研究中,由于观察位置存在已知损伤,作者几乎没有达到该范围内的数值。
{"title":"Commentary on: Downing NR, Scafide KN, Ali Z, Hayat MJ. Visibility of inflicted bruises by alternate light: Results of a randomized controlled trial. J Forensic Sci. 2024;69(3):880–7. https://doi.org/10.1111/1556-4029.15481","authors":"William Hauda II MD,&nbsp;Sue Rotolo PhD, RN,&nbsp;Ralph Riviello MD,&nbsp;W. Anthony Gerard MD","doi":"10.1111/1556-4029.15599","DOIUrl":"10.1111/1556-4029.15599","url":null,"abstract":"&lt;p&gt;We read with interest the article by Downing NR, et al. regarding the use of alternate light to view bruises [&lt;span&gt;1&lt;/span&gt;]. We agree with the authors that the identification of injuries in patients who have experienced physical violence is important. As colleagues who are forensic medicine experts, we recognize the importance of visualizing bruises in cases of interpersonal violence, especially in individuals with darkly pigmented skin, so we applaud your research on this issue. Practitioners need to be as accurate as possible in their evaluation. The use of tools to assist in the identification of injuries can be very helpful. We also recognize that forensic sciences and the associated analysis or evaluation must remain accurate and valid and not utilize “presumptive tests without confirmation” or tests lacking “reliability, reproducibility, repeatability, and replicability” [&lt;span&gt;2, 3&lt;/span&gt;].&lt;/p&gt;&lt;p&gt;When reading this article, we were struck by the remarkable similarity in methods with previous publications by these authors on this topic [&lt;span&gt;4, 5&lt;/span&gt;]. All three studies have the same number of 157 participants. This study and the study published in 2020 describe the same methodology of “quota sampling” to “recruit equal numbers of healthy participants.” The study published in 2022, however, stated that “a convenience sample of 157 subjects” was obtained. If these studies are of the same participants, then the statement in the 2022 publication about how the participants were recruited appears to be incorrect and potentially misleading. We are concerned that multiple studies analyzing the same data set create an improper opportunity for bias and post hoc analysis error.&lt;/p&gt;&lt;p&gt;The authors found in a previous analysis of the participants that both the 415 nm ALS with a yellow filter and the 450 nm ALS with a yellow filter to be “optimal for detecting evidence of bruising on individuals with known trauma” [&lt;span&gt;5&lt;/span&gt;]. This was also apparent from table 5 of their 2020 study with the same data [&lt;span&gt;4&lt;/span&gt;]. With this current publication, the authors state “only 415nm viewed through a yellow filter resulted in a clinically meaningful improvement (0.46 points) in visibility rating when compared to white light.” [&lt;span&gt;1&lt;/span&gt;] In figure 1, of this study, we find it difficult to visually discern any difference between the various light frequencies used in very light skin or very dark skin. Additionally, we noted that all modalities of light had reduced visualization of bruises; no modality was clearly better in most or all skin color categories.&lt;/p&gt;&lt;p&gt;Reviewing table 2 in this recent paper shows that the 450 nm ALS with the yellow filter did not have as high a visibility rating improvement, but it was the only other assessment with a visibility rating improvement above 0.2. How should the reader discern what a clinically meaningful improvement in the visibility score would be?&lt;/p&gt;&lt;p&gt;Based upon the methods described by the authors, t","PeriodicalId":15743,"journal":{"name":"Journal of forensic sciences","volume":"69 6","pages":"2339-2341"},"PeriodicalIF":1.5,"publicationDate":"2024-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/1556-4029.15599","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141989835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Authors' response 作者回复。
IF 1.5 4区 医学 Q2 MEDICINE, LEGAL Pub Date : 2024-08-16 DOI: 10.1111/1556-4029.15600
Nancy R. Downing PhD, RN, Katherine N. Scafide PhD, RN, Zahra Ali MPH, Matthew J. Hayat PhD
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引用次数: 0
Correction to: The false promise of firearms examination validation studies: Lay controls, simplistic comparisons, and the failure to soundly measure misidentification rates 更正:枪支检查验证研究的虚假承诺:外行控制、简单化比较以及未能正确衡量错误识别率。
IF 1.5 4区 医学 Q2 MEDICINE, LEGAL Pub Date : 2024-08-16 DOI: 10.1111/1556-4029.15602

Gutierrez RE, Prokesch EJ. The false promise of firearms examination validation studies: Lay controls, simplistic comparisons, and the failure to soundly measure misidentification rates. J Forensic Sci. 2024;69(4):1334–49. https://doi.org/10.1111/1556-4029.15531

The list of affiliations listed for RE Gutierrez has been modified; in that, the Academy Standards Board, Firearms and Toolmarks Consensus Body, has been removed. This comunication also corrects two inadvertent typographical errors from the publication. First, Reference 53 included a misspelling of Dr. Ryan Lilien’s name (“Lillien” as opposed to the correct “Lilien”). Second, Table 2 provided an incorrect value for the inconclusive rate on different source comparisons for the “Duez examiners” group (15% as opposed to the correct 13%). That typographical error did not, however, carry over into other figures and calculations (e.g. confidence intervals) provided throughout the remainder of the piece.

We apologize for these errors.

Gutierrez RE, Prokesch EJ.枪支检查验证研究的虚假承诺:外行控制、简单化比较以及未能正确衡量错误识别率。J Forensic Sci. 2024;69(4):1334-49。https://doi.org/10.1111/1556-4029.15531The,对RE Gutierrez的所属机构列表进行了修改;其中,学院标准委员会、枪支和工具印记共识机构已被删除。本通报还纠正了出版物中两处无心的排印错误。首先,参考文献 53 中的 Ryan Lilien 博士的名字拼写错误("Lillien "而不是正确的 "Lilien")。其次,表 2 提供的 "Duez 检验人员 "组不同来源比较的无结论率数值有误(15%,而正确的是 13%)。但这一排版错误并不影响文章其余部分提供的其他数字和计算(如置信区间)。
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引用次数: 0
Introduction to the JFS Special Section on Disaster Victim Identification (DVI) JFS 灾民身份识别(DVI)特别小组简介。
IF 1.5 4区 医学 Q2 MEDICINE, LEGAL Pub Date : 2024-08-14 DOI: 10.1111/1556-4029.15603
Michael A. Peat PhD, Suni M. Edson PhD, Mechthild Prinz PhD
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引用次数: 0
EXPRESSION OF CONCERN: Forensic Investigation of a Shawl Linked to the “Jack the Ripper” Murders 表达关切:对与 "开膛手杰克 "谋杀案有关的披肩的法医调查。
IF 1.5 4区 医学 Q2 MEDICINE, LEGAL Pub Date : 2024-08-12 DOI: 10.1111/1556-4029.15595

EXPRESSION OF CONCERN: J. Louhelainen, and D. Miller, “Forensic Investigation of a Shawl Linked to the “Jack the Ripper” Murders.” Journal of Forensic Sciences 65 no. 1 (2020): 295–303, https://doi.org/10.1111/1556-4029.14038.

This Expression of Concern is for the above article, published online on 12 March 2019 in Wiley Online Library (wileyonlinelibrary.com), and has been published by agreement between the journal Editor-in-Chief, Michael Peat; and the Publisher, Wiley Periodicals LLC, on behalf of the American Academy of Forensic Sciences. Following an investigation by the publisher, the Expression of Concern has been agreed due to concerns raised by third parties after publication regarding the conclusions drawn from the mtDNA analysis performed by the authors. Related concerns were also summarized in two Letters to the Editor [1, 2] published by the journal, to which the authors responded with their own Letters to the Editor [3, 4]. During the investigation, the publisher and Editor-in-Chief made every effort to obtain from the authors the original raw data from the mtDNA analysis. However, the authors stated that the data were no longer available, due to instrument data failure and other complications. Through further investigation it was concluded that, because it was not possible to examine the original data, no determination could be made regarding the third-party complaints. The journal is issuing this Expression of Concern because the concerns regarding the data and the results presented cannot be resolved. The authors have been informed about this Expression of Concern and agree to its publication.

表达关注:J. Louhelainen 和 D. Miller,"与'开膛手杰克'谋杀案有关的披肩的法医调查"。Journal of Forensic Sciences 65 no. 1 (2020): 295-303, https://doi.org/10.1111/1556-4029.14038.This Expression of Concern是针对2019年3月12日在线发表在Wiley Online Library (wileyonlinelibrary.com)上的上述文章,由期刊主编迈克尔-皮特(Michael Peat)和出版商Wiley Periodicals LLC代表美国法医科学院协议出版。经出版商调查,由于第三方在文章发表后对作者进行的 mtDNA 分析得出的结论表示担忧,因此同意发表《关注声明》。该期刊发表的两封致编辑的信[1, 2]中也总结了相关问题,作者在自己的致编辑的信[3, 4]中对此进行了回应。在调查过程中,出版商和主编尽一切努力向作者索取 mtDNA 分析的原始数据。然而,作者表示,由于仪器数据故障和其他并发症,这些数据已不再可用。通过进一步调查,得出的结论是,由于无法检查原始数据,因此无法对第三方的投诉做出决定。由于无法解决有关数据和结果的问题,本刊特发布本《关注函》。作者已被告知本 "关注函",并同意发表本 "关注函"。
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引用次数: 0
The quantitative and qualitative analysis of dye in fentanyl tablets via ultraviolet-visible spectroscopy—A forensic approach 通过紫外可见光谱定量和定性分析芬太尼片剂中的染料--一种法医学方法。
IF 1.5 4区 医学 Q2 MEDICINE, LEGAL Pub Date : 2024-08-12 DOI: 10.1111/1556-4029.15598
Charley K. Mitchell BS, Jonathan C. Dumke PhD, Charlotte A. Corbett PhD, Laura M. Jones BS, Kristin E. Ceniccola-Campos PhD

In the United States, illicit fentanyl is often trafficked as blue tablets mimicking the legitimate M-30 oxycodone tablet produced by Mallinckrodt. The analysis of dyes extracted from seized fentanyl tablets could provide a useful tool for law enforcement to establish linkages between cases and could prove useful for attributing a seizure to a given trafficking organization. Fentanyl tablet seizures associated with a particular drug trafficking organization (DTO), either through investigative or intelligence information, were used as the sample set for this study. The blue dye from the tablets was isolated by solid phase extraction and then qualitatively and quantitatively analyzed via ultraviolet-visible spectroscopy. This research revealed that the illicit tableting facilities use a different dye than several known pharmaceutical companies. The concentration of dye in individual tablets within a seizure proved to be very minimal, and the small sample size made it difficult to draw linkages from case to case. Analysis of the dyes could not effectively differentiate between the drug trafficking organizations in the tested population due to each DTO using the same dye; however, it is important to note that the dye found was consistent between illicit tablets.

在美国,非法芬太尼通常以模仿 Mallinckrodt 公司生产的合法 M-30 羟考酮片剂的蓝色片剂形式贩运。对从缉获的芬太尼药片中提取的染料进行分析,可为执法部门提供有用的工具,以建立案件之间的联系,并可证明有助于将缉获归咎于特定的贩运组织。与特定贩毒组织(DTO)有关的芬太尼药片缉获量(通过调查或情报信息)被用作本研究的样本集。通过固相萃取从药片中分离出蓝色染料,然后通过紫外可见光谱进行定性和定量分析。这项研究发现,非法制片厂使用的染料与几家已知制药公司使用的染料不同。事实证明,缉获的单个药片中的染料浓度非常低,而且样本量较小,因此很难将不同案件联系起来。由于每个贩毒组织都使用同一种染料,因此对染料的分析无法有效区分被检测人群中的贩毒组织;但必须指出的是,在非法药片中发现的染料是一致的。
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引用次数: 0
Prevalence of fentanyl in the pediatric postmortem population from 2019 to 2023 2019年至2023年芬太尼在儿科尸检人群中的流行率。
IF 1.5 4区 医学 Q2 MEDICINE, LEGAL Pub Date : 2024-08-11 DOI: 10.1111/1556-4029.15596
Brianna L. Peterson PhD, Kari M. Midthun PhD

For the past decade, illicitly manufactured fentanyl has been a primary contributor in drug overdose deaths regardless of age. The pediatric population is particularly vulnerable to fentanyl exposure, yet there are limited case reports involving this population. Postmortem cases from 2019 to 2023 were retrospectively analyzed to determine the prevalence of fentanyl in decedents between 0 and 12 years of age. Over this time frame, the fentanyl positivity rate increased from 2.6 to 6.2% (n = 632). The most commonly reported age group was 0–4 years, with a peak around 1 year of age for toddlers. Fentanyl concentrations in blood (n = 573) ranged from 0.19 to 360 ng/mL (mean 18 ng/mL, median 6.9 ng/mL). Polydrug use was present in 428 cases; midazolam (n = 96) and methamphetamine (n = 66) were the most common drugs found concurrently in blood with fentanyl, followed by markers of illicitly manufactured fentanyl, such as xylazine (n = 23), para-fluorofentanyl (n = 18), and acetyl fentanyl (n = 17). This report contrasts the differences in postmortem pediatric fentanyl toxicology results for three groups of case histories: likely medical intervention (n = 113), pregnancy/birth related (n = 136), and inadvertent/intentional exposure (n = 196). Overall, this study provides a retrospective review of postmortem pediatric fentanyl concentrations in a variety of biological matrices and highlights the need for comprehensive toxicology testing in postmortem pediatric casework.

在过去的十年中,非法制造的芬太尼一直是导致吸毒过量死亡的主要原因,不分年龄。儿科人群尤其容易接触芬太尼,但涉及这一人群的病例报告却很有限。我们对 2019 年至 2023 年的尸检病例进行了回顾性分析,以确定芬太尼在 0 至 12 岁死者中的流行率。在这段时间内,芬太尼阳性率从 2.6% 上升至 6.2%(n = 632)。最常报告的年龄组是 0-4 岁,幼儿在 1 岁左右达到高峰。血液中的芬太尼浓度(n = 573)从 0.19 毫微克/毫升到 360 毫微克/毫升不等(平均值为 18 毫微克/毫升,中位值为 6.9 毫微克/毫升)。在 428 例病例中存在使用多种药物的情况;咪达唑仑(n = 96)和甲基苯丙胺(n = 66)是血液中发现的与芬太尼同时存在的最常见药物,其次是非法制造的芬太尼的标记物,如恶嗪(n = 23)、对氟芬太尼(n = 18)和乙酰芬太尼(n = 17)。本报告对比了三组病例中小儿芬太尼死后毒理结果的差异:可能的医疗干预(n = 113)、与妊娠/分娩相关(n = 136)和无意/有意暴露(n = 196)。总之,本研究对小儿死后芬太尼在各种生物基质中的浓度进行了回顾性分析,并强调了在小儿死后病例工作中进行全面毒理学检测的必要性。
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引用次数: 0
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Journal of forensic sciences
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