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Determining storage for pressure-sensitive tape evidence: A long-term study 确定压敏胶带证据的存储:长期研究。
IF 1.5 4区 医学 Q2 MEDICINE, LEGAL Pub Date : 2024-08-09 DOI: 10.1111/1556-4029.15590
Susan T. Gross MSFS

Tape is a type of trace evidence commonly seen in forensic science. Little to no research has been published regarding the optimal storage material for pressure-sensitive adhesive (PSA) tape. The purpose of this project was to determine the substrate with the least amount of interference for storing PSA tape. Interferences such as difficulty removing tape from the substrate or substrate components leaching into the adhesive can affect the analysis. This was a long-term study in which samples were stored on various substrates for nearly 10 years. Ten different tape samples were placed on eight different substrates for a total of 80 samples. The substrates included typical materials currently used for tape storage as well as other, less common materials. The tape samples were evaluated for ease of removal at various time intervals. The adhesives from each tape were analyzed at similar time intervals by Fourier transform infrared spectroscopy (FTIR). In addition, the adhesives were analyzed by pyrolysis gas chromatography–mass spectrometry (PyGC-MS), scanning electron microscopy with energy-dispersive spectroscopy (SEM-EDS), and x-ray fluorescence (XRF) at the last time interval (112 months) and compared to the adhesive tape samples from the original rolls of tape to determine if there was any adverse effect from the substrates during storage. The FedEx backing was the only substrate that had no adverse effects regarding ease of removal. The substrates that had the least effect on the adhesive for both short-term and long-term storage included FedEx backings, adhesive sheet backings, and polyester transparency sheets.

胶带是法医学中常见的一种痕迹证据。关于压敏胶(PSA)胶带的最佳储存材料,几乎没有任何研究成果。本项目的目的是确定对储存 PSA 胶带干扰最小的基质。从基材上取下胶带困难或基材成分浸入胶粘剂等干扰都会影响分析结果。这是一项长期研究,样品在不同的基底上存放了近 10 年。十种不同的胶带样品被放置在八种不同的基底上,共计 80 个样品。这些基材包括目前用于磁带存储的典型材料以及其他不太常见的材料。在不同的时间间隔内对胶带样本的易撕性进行了评估。在类似的时间间隔内,用傅立叶变换红外光谱(FTIR)对每种胶带的粘合剂进行分析。此外,在最后一个时间间隔(112 个月),通过热解气相色谱-质谱法(PyGC-MS)、扫描电子显微镜与能量色散光谱法(SEM-EDS)和 X 射线荧光法(XRF)对粘合剂进行分析,并与原始胶带卷的胶带样本进行比较,以确定储存期间基材是否会产生任何不利影响。联邦快递背衬是唯一一种在易撕性方面没有不良影响的基材。在短期和长期储存中对粘合剂影响最小的基材包括联邦快递背胶、胶片背胶和聚酯透明片。
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引用次数: 0
Use of presence vs absence of symphyseal teeth in jaws for the forensic analysis of bites by large traumatogenic shark species 利用下颌中是否存在合骨齿对大型创伤性鲨鱼物种的咬伤进行法医分析。
IF 1.5 4区 医学 Q2 MEDICINE, LEGAL Pub Date : 2024-08-08 DOI: 10.1111/1556-4029.15594
Eric E. Clua DVM, PhD, Simon DeMarchi MSc, Dennis Reid MSc

Identifying the species of shark responsible for a bite on humans is both complex and important for understanding and managing the shark risk. Depending on the species, tiny teeth may or may not be present in the symphyseal space at the junction of the upper and lower half-jaws. In the case of bites, these tiny teeth (if present) often leave specific marks that may enable species to be quickly and reliably distinguished. We first present the anatomo-morphological characteristics of the jaws of the three most traumatogenic species for humans which are the white, tiger, and bull sharks. The white shark has no symphyseal teeth, while the tiger and bull sharks do. On the basis of three confirmed real case studies involving those species, we then show that for the white shark, the wide symphyseal space between the first two teeth of each jaw usually leads to wounds including the presence of (quite) large flesh flaps, without any tooth imprint. Conversely, wounds following bites made by the tiger and bull sharks will generally leave characteristic small imprints of symphyseal teeth, especially in the case of incomplete or superficial bites. Although not systematic, this diagnostic approach provides fast, reliable, and clean results. The discrimination between two species with symphyseal teeth can then be made on the basis of complementary anatomic information such as jaw curvature and details linked to the anatomy of the teeth themselves, as well as the ecological context.

确定咬伤人类的鲨鱼种类对于了解和管理鲨鱼风险既复杂又重要。根据鲨鱼种类的不同,鲨鱼上下半颌交界处的齿间可能有也可能没有细小的牙齿。在被咬伤的情况下,这些细小的牙齿(如果存在)通常会留下特定的痕迹,从而可以快速可靠地区分鲨鱼的种类。我们首先介绍白鲨、虎鲨和公牛鲨这三种对人类伤害最大的鲨鱼颌部解剖形态特征。白鲨没有共生齿,而虎鲨和公牛鲨有。根据涉及这些物种的三个经证实的真实案例研究,我们随后表明,对于白鲨来说,每个下颌的前两颗牙齿之间宽阔的齿间空间通常会导致伤口,包括出现(相当)大的肉瓣,而没有任何牙齿印记。相反,被虎鲨和公牛鲨咬伤后的伤口通常会留下特征性的小的合骨齿印,特别是在不完全咬伤或浅表咬伤的情况下。这种诊断方法虽然不是系统性的,但能提供快速、可靠和干净的结果。然后就可以根据互补的解剖学信息(如下颌弧度和与牙齿本身解剖学相关的细节)以及生态环境来区分具有合骨齿的两个物种。
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引用次数: 0
Estimation of sex assigned at birth using dental crown and cervical measurements in a modern global sample 在现代全球样本中使用牙冠和宫颈测量估计出生时的性别分配。
IF 1.5 4区 医学 Q2 MEDICINE, LEGAL Pub Date : 2024-08-08 DOI: 10.1111/1556-4029.15593
Marin A. Pilloud PhD, Dori E. Kenessey PhD, Emily M. Smith MA, Tatiana Vlemincq-Mendieta PhD

Despite developing prior to the appearance of secondary sexual characteristics of the skeleton, the permanent dentition exhibits sexual dimorphism. Therefore, teeth can serve as a means to estimate sex assigned at birth even in young individuals. This project takes a large global sample of maximum dimensions of the crown as well as measurements of the crown at the cervix to explore sexual dimorphism. Dimorphism is noted in teeth throughout the dental arcade, particularly in the canines. We provide sectioning points as well as the probability of correct classification (ranging from 50.9% to 81.3%) for each measurement to aid the practitioner in sex estimation from the dentition. This research provides a method to estimate sex without arbitrary population specifications. We argue for a global approach that incorporates more population variation to remove the need to estimate “ancestry,” (which in actuality is translated to a social race category) and therefore does not force sexual dimorphism-related variation into these mutable and ambiguous categories. Further, this paper demonstrates the utility of the dentition as an additional indicator to aid with the estimation of sex assigned at birth in forensic anthropology. The goal of this research is to better understand the expression of sexual dimorphism across the skeleton in a global context.

尽管恒牙在骨骼第二性征出现之前就已发育,但恒牙仍表现出性别二形性。因此,牙齿可以作为一种手段来估计出生时的性别分配,即使是年轻个体也不例外。该项目对牙冠的最大尺寸以及宫颈处牙冠的测量进行了大规模的全球抽样,以探索性双态性。在整个牙弓,尤其是犬齿的牙齿上都能发现二态性。我们提供了切片点以及每次测量的正确分类概率(从 50.9% 到 81.3%),以帮助从业人员根据牙列估计性别。这项研究提供了一种无需任意人口规格即可估计性别的方法。我们主张采用一种包含更多人口变异的全球方法,以消除估计 "祖先 "的需要("祖先 "实际上被转换为社会种族类别),因此不会将与性二型相关的变异强加到这些易变和模糊的类别中。此外,本文还展示了在法医人类学中将牙齿作为额外指标来帮助估计出生时性别的实用性。这项研究的目标是在全球范围内更好地了解骨骼的性别二形性表现。
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引用次数: 0
Forensic application of sandpaper spray ionization mass spectrometry (SPS-MS): Direct analysis of solid pharmaceutical formulations and edible cannabis products 砂纸喷雾电离质谱法(SPS-MS)的法医应用:直接分析固体药物制剂和食用大麻产品。
IF 1.5 4区 医学 Q2 MEDICINE, LEGAL Pub Date : 2024-08-05 DOI: 10.1111/1556-4029.15592
Karl Angelo M. Rodrillo BSc, Diego M. Costa MSc, Sarah F. C. Viana BSc, Hasti Shahbazi, Rodinei Augusti PhD, Demian R. Ifa PhD

In this work, we employed a new ambient ionization mass spectrometry technique, sandpaper spray mass spectrometry (SPS-MS), as an efficient tool to analyze pills and tablets of pharmaceutical formulations. The following samples were analyzed: regulators of blood pressure, cholesterol, and diabetes, and drugs for the treatment of erectile dysfunction (ED). Additionally, a hard candy of Cannabis sativa containing Δ9-tetrahydrocannabinol (Δ9-THC) and its related isomer cannabidiol (CBD) was also evaluated. The surfaces of the samples, without any prior treatment, were sanded onto triangular-cut sandpaper, and full MS scans (and MS/MS) were acquired in both positive and negative ionization modes. SPS-MS (and MS/MS) allowed for prompt detection of the active pharmaceutical ingredients (APIs) in each formulation. Other components of the formulations, added as excipients, were also tentatively identified. The results described herein indicate that the SPS-MS technique can be applied to fast screening of pills and tablets being potentially used as an efficient tool to detect counterfeit pharmaceutical and illicit products, a current issue of increasing concern.

在这项工作中,我们采用了一种新的环境电离质谱技术--砂纸喷雾质谱(SPS-MS),作为分析药物制剂药丸和药片的有效工具。分析了以下样品:血压、胆固醇和糖尿病调节剂,以及治疗勃起功能障碍(ED)的药物。此外,还对一种含有Δ9-四氢大麻酚(Δ9-THC)及其相关异构体大麻二酚(CBD)的大麻硬糖进行了评估。样品表面未经任何事先处理,用三角切割砂纸打磨后,在正离子和负离子模式下获得完整的 MS 扫描(和 MS/MS)。通过 SPS-MS(和 MS/MS)可迅速检测出每种配方中的活性药物成分 (API)。制剂中作为辅料添加的其他成分也得到了初步鉴定。本文描述的结果表明,SPS-MS 技术可用于快速筛查药丸和药片,有可能成为检测假冒药品和非法产品的有效工具,这是当前日益受到关注的一个问题。
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引用次数: 0
A comparative review of error rates in forensic handwriting examination 法医笔迹鉴定中错误率的比较研究。
IF 1.5 4区 医学 Q2 MEDICINE, LEGAL Pub Date : 2024-07-28 DOI: 10.1111/1556-4029.15589
Sébastien Crot BSc, Raymond Marquis PhD

A comparison of error rates between studies in forensic handwriting examination has been made in response to the lack of knowledge on error in this field. Fifteen indicators have been used to describe and compare error rates between studies. The results of each study have been processed to determine these indicators. Parameters related to the participants, conclusion scale, amount of time allocated to the task, and the task itself are also reported. The error rate indicators are provided for each study, and then combined across studies using values of mean and standard deviation. Experts were found to perform better than laypeople. For handwritten texts, absolute error rate for experts ranges from 0.32% to 5.85% (with a mean of 2.84 ± 2.33%), and for laypeople from 11.43% to 28.72% (with a mean of 21.40 ± 8.94%). For signatures, absolute error rate for experts ranges from 0% to 4.86% (with a mean of 2.50 ± 1.55%), and for laypeople from 10.68% to 28% (with a mean of 19.55 ± 7.05%). Overall, experts have an absolute error rate of 2.63 ± 1.73% (against 20.16 ± 7.20% for laypeople). Experts are also more likely to give inconclusive answers than laypeople. Overall, the rate of absolute inconclusive answers for experts is 21.96 ± 23.15% (against 8.13 ± 7.96% for laypeople). The comparative review of error rates presented in the present article contributes to validating the discipline by showing how research has been devoted to meeting the criteria of testing to be considered scientific.

针对法医笔迹鉴定领域误差知识的匮乏,我们对不同研究之间的误差率进行了比较。我们使用了 15 项指标来描述和比较不同研究之间的错误率。每项研究的结果都经过处理,以确定这些指标。此外,还报告了与参与者、结论尺度、分配给任务的时间以及任务本身有关的参数。每项研究都提供了错误率指标,然后使用平均值和标准偏差值对各项研究进行合并。研究发现,专家的表现优于普通人。对于手写文本,专家的绝对错误率从 0.32% 到 5.85%(平均值为 2.84 ± 2.33%)不等,普通人的绝对错误率从 11.43% 到 28.72%(平均值为 21.40 ± 8.94%)不等。在签名方面,专家的绝对错误率为 0% 至 4.86%(平均值为 2.50 ± 1.55%),非专业人员的绝对错误率为 10.68% 至 28%(平均值为 19.55 ± 7.05%)。总体而言,专家的绝对错误率为 2.63 ± 1.73%(非专业人员为 20.16 ± 7.20%)。专家也比普通人更容易给出不确定的答案。总体而言,专家的绝对不确定答案率为 21.96 ± 23.15%(非专业人员为 8.13 ± 7.96%)。本文对误差率进行的比较审查显示了研究是如何致力于达到测试标准以被视为科学的,从而为验证该学科做出了贡献。
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引用次数: 0
The “t” time: Investigating handedness through strokes and slopes t "时间通过笔画和斜线研究手性。
IF 1.5 4区 医学 Q2 MEDICINE, LEGAL Pub Date : 2024-07-25 DOI: 10.1111/1556-4029.15591
Kata Šunjić BSc, Ana Banovac MSc, Tijana Kafadar BSc, Nena Džin BSc, Marko Žeravica BSc, Petra Mikulić BSc, Ana Penava BSc, Adriana Kulišić BSc, Zlatka Hajdić BSc, Ivana Kružić PhD, Ivan Jerković PhD, Željana Bašić PhD

This study investigated the stroke and slope characteristics in left-handed and right-handed handwriting. Stroke (letters t, f, đ, and H) and slope (letters t, f, l, d, and g) directions were analyzed on in-house samples (n = 64), revealing statistically significant differences (p ≤ 0.05) between the groups. Right-handers predominantly exhibited left-to-right strokes (98%–100%), while left-handers showed greater variability. Although statistically significant for most letters analyzed, slope direction did not demonstrate consistent patterns. A logistic regression model was developed and validated on the same sample to classify handedness based on the averaged strokes of the letter “t.” The model was further tested on samples (n = 252) from a publicly available handwriting database. If the model classified the sample as produced by left hand, it was correct in 100% of cases. In contrast, when the model classified writing as right-handed, it was correct in 73%–97% of cases, depending on the validation sample. The model classified writing as of left-handed origin if more than 36% of the letters “t” had a stroke from right to left, while otherwise, writing was classified as of right-handed origin. The developed method showed great potential for classifying the handedness of the author of disputed handwriting, thus eliminating individuals as text authors or narrowing down the pool of potential authors.

本研究调查了左撇子和右撇子笔迹的笔画和斜率特征。对内部样本(n = 64)的笔画(字母 t、f、đ 和 H)和斜率(字母 t、f、l、d 和 g)方向进行了分析,发现两组之间存在显著的统计学差异(p ≤ 0.05)。右撇子主要表现为从左到右的笔画(98%-100%),而左撇子则表现出更大的差异性。虽然对大多数字母的分析具有统计学意义,但斜率方向并没有表现出一致的模式。根据字母 "t "的平均笔画,建立了一个逻辑回归模型,并在同一样本上进行了验证,以对惯用手进行分类。该模型在一个公开的笔迹数据库中的样本(n = 252)上进行了进一步测试。如果该模型将样本归类为左手书写,其正确率为 100%。相反,当模型将书写归类为右手书写时,根据验证样本的不同,正确率在 73%-97% 之间。如果超过 36% 的字母 "t "的笔画从右到左,模型就会将书写归类为左撇子书写,反之,则归类为右撇子书写。所开发的方法在对有争议笔迹的作者的手型进行分类方面显示出巨大的潜力,从而排除了作为文本作者的个人或缩小了潜在作者的范围。
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引用次数: 0
A proposal for cut marks classification using machine learning: Serrated vs. non-serrated, single vs. double-beveled knives 利用机器学习进行刀痕分类的建议:锯齿刀与无锯齿刀、单刃刀与双刃刀。
IF 1.5 4区 医学 Q2 MEDICINE, LEGAL Pub Date : 2024-07-25 DOI: 10.1111/1556-4029.15588
Giada Sciâdi Steiger MSc, Matteo Borrini PhD

In tool mark identification, there is still a lack of characteristics and methodologies standardization used to analyze and describe sharp force trauma marks on skeletal remains. This study presents a classification method for cut marks on human bones, providing an applicable methodology for their examination and the relevant terminology for describing cases of sharp force trauma. A total of 350 cut marks were produced by stabbing pig ribs (Sus scrofa) with seven knives. The samples were analyzed under a stereomicroscope with a tangential light source. Through the analysis of cut marks, eleven traits were identified as significantly associated with the type of knife used. These traits included the general morphology of the kerf shape, the entrance and exit cross-profile shapes, the location of the rising on the entrance and exit cross-profile, the presence or absence of feathering, the presence or absence of shards and the location and the general morphology of the mounding. Binary logistic regression models were later trained and tested using nine out of the eleven traits. The first model categorized the cut mark as either produced by a serrated or non-serrated blade, while the second, as either produced by a single- or double-beveled blade. Classification scores of those models ranged between 63%–85% for the serration class and 63%–89% for the blade bevel class. This study proposes a new set of traits and the use of machine learning models to standardize and facilitate the analysis of stab wounds.

在工具痕迹鉴定方面,仍然缺乏用于分析和描述骸骨上锐器创伤痕迹的标准化特征和方法。本研究提出了人类骨骼上切割痕迹的分类方法,为其检查提供了适用的方法,并提供了描述锐器创伤案例的相关术语。研究人员用七把刀刺入猪(Sus scrofa)的肋骨,共产生了 350 个切割痕。样本在带有切向光源的体视显微镜下进行分析。通过对切痕的分析,确定了与所用刀具类型有显著关联的 11 个特征。这些特征包括切口形状的总体形态、入口和出口横截面形状、入口和出口横截面上隆起的位置、有无羽化、有无碎片以及堆积的位置和总体形态。随后使用 11 个特征中的 9 个对二元逻辑回归模型进行了训练和测试。第一个模型将切割痕迹分为锯齿状或无锯齿状,第二个模型将切割痕迹分为单刃或双刃。这些模型的锯齿分类得分率在 63%-85% 之间,刀刃斜面分类得分率在 63%-89% 之间。这项研究提出了一套新的特征,并使用机器学习模型来规范和促进对刺伤的分析。
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引用次数: 0
Forensic psychiatric assessment in autism spectrum disorder: Experience of a forensic psychiatry inpatient clinic from Türkiye 自闭症谱系障碍的法医精神病学评估:土耳其法医精神病住院诊所的经验。
IF 1.5 4区 医学 Q2 MEDICINE, LEGAL Pub Date : 2024-07-22 DOI: 10.1111/1556-4029.15586
Muhammed Emin Boylu MD, İlker Taşdemir MD, Mehmet Doğan MD, Tuba Özcanlı MD

Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by marked differences in communication patterns, reciprocal social interactions, and restricted, stereotyped, and repetitive interests and activities. Various behavioral problems in ASD, more so when accompanied by coexisting psychopathology, can sometimes lead to legal problems. In this study, the cases in which an opinion was requested in terms of criminal responsibility with the diagnosis of ASD in the 5-year period between 2018 and 2022 in the expertise department of psychiatric observation, where psychiatric cases were hospitalized and observed in the Council of Forensic Medicine (CFM), which is the official expert institution in Türkiye, were retrospectively evaluated. The mean age of the group whose criminal responsibility was reduced or removed was 22.9 years (±7.52) and the mean IQ score was 76.63 ± 18.94. The most common crime in this group was intentional injury (5/11), and it is noteworthy that the victims of these crimes were usually relatives of people with ASD (5/6). The criminal acts of people with ASD are usually single-movement, spontaneous, unplanned, impulsive acts. In addition, although there is no problem in cognitive perception in people with high functioning ASD (HF-ASD), various forensic situations may arise due to defects in emotional awareness. When we look at the practices of the CFM in Türkiye, it is seen that in cases where the diagnosis of ASD is clear and can be associated with the crime, criminal responsibility is usually completely eliminated. In HF-ASD types, although it is important to be associated with the crime, it is seen that criminal responsibility is generally reduced.

自闭症谱系障碍(ASD)是一种神经发育性疾病,其特征是在沟通模式、互惠的社会交往以及受限的、刻板的和重复的兴趣和活动方面存在明显差异。ASD 中的各种行为问题,尤其是同时伴有精神病理学时,有时会导致法律问题。在本研究中,对 2018 年至 2022 年的 5 年间,在法医委员会(土耳其的官方专家机构)的精神病观察专业部门(精神病患者在该部门住院并接受观察)中,诊断为 ASD 的刑事责任鉴定申请案例进行了回顾性评估。刑事责任减轻或免除组的平均年龄为 22.9 岁(±7.52),平均智商为 76.63 分(±18.94)。在这一组中,最常见的犯罪行为是故意伤害(5/11),值得注意的是,这些犯罪行为的受害者通常是自闭症患者的亲属(5/6)。自闭症患者的犯罪行为通常是单一动作、自发、无计划、冲动的行为。此外,虽然高功能自闭症患者在认知感知方面没有问题,但由于情绪意识方面的缺陷,可能会出现各种法医情况。综观土耳其刑事法院的做法,如果 ASD 诊断明确并与犯罪相关联,通常可以完全免除刑事责任。在高频-自闭症类型中,尽管与犯罪相关联很重要,但可以看到刑事责任通常会减轻。
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引用次数: 0
Sexual dimorphism of pelvic scarring: A new method of adult biological sex estimation 骨盆瘢痕的性别双态性:成人生物学性别估计的新方法。
IF 1.5 4区 医学 Q2 MEDICINE, LEGAL Pub Date : 2024-07-22 DOI: 10.1111/1556-4029.15587
Georgina Ives MSc, Sarah E. Johns PhD, Chris Deter PhD

Estimating biological sex is a crucial aspect of forensic anthropology, and is pivotal in forensic investigations. Presently, the most frequently adopted osteological sex estimation methods focus on the anterior pelvis, which is easily susceptible to postmortem damage, revealing a need for additional accurate methods. This study introduces a novel method for estimating adult sex through metric pelvic scar analysis, using a known skeletal sample (169 females; 51 males). Relationships between sex and scar dimensions were subjected to Kendall's tau-B testing, and the strongest associated measurements were further analyzed using binary logistic regression to determine their predictive capacity. The final estimation method was tested on an additional known-sex sample of 43 males and 43 females from the Spitalfields skeletal collection. All associations between biological sex and scar measurements were significant, with the preauricular sulcus and newly defined inferior interosseous cavity presenting the strongest relationships (τb 0.223–0.504). Individual regression models using the approximate volume of each feature predicted sex with over 80% accuracy, but when combined in a single regression model, the accuracy increased to an impressive 97.1%. When then applied to the validation sample, the final estimation model achieved an accuracy of 90.7%. These results highlight the high estimation accuracy achieved by simultaneously utilizing the approximate volume of the sulcus and the inferior cavity. This is not only highly accurate but also utilizes the sturdier posterior pelvis, making it a promising tool for forensic investigations and the wider field of osteology.

估计生物性别是法医人类学的一个重要方面,也是法医调查的关键。目前,最常用的骨学性别估计方法主要集中在骨盆前部,而骨盆前部很容易受到死后损伤,因此需要更多精确的方法。本研究利用已知的骨骼样本(169 名女性;51 名男性),介绍了一种通过骨盆疤痕度量分析来估计成人性别的新方法。性别与疤痕尺寸之间的关系经过了 Kendall's tau-B 检验,并使用二元逻辑回归进一步分析了相关性最强的测量值,以确定其预测能力。最终的估算方法在斯皮塔菲尔兹骨骼采集的另外一个已知性别样本(43 名男性和 43 名女性)上进行了测试。生物性别与疤痕测量值之间的关系都很显著,其中耳前沟和新定义的下骨间腔关系最密切(τb 0.223-0.504)。使用每个特征的近似体积建立的单独回归模型预测性别的准确率超过 80%,而将其合并到单一回归模型中时,准确率提高到了令人印象深刻的 97.1%。当应用于验证样本时,最终估计模型的准确率达到了 90.7%。这些结果凸显了同时利用凹槽和下腔的近似体积所实现的高估算精度。这不仅具有很高的准确性,而且还利用了更坚固的后骨盆,使其成为法医调查和更广泛的骨学领域的一种有前途的工具。
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引用次数: 0
Review of SNP assays for disaster victim identification: Cost, time, and performance information for decision-makers 灾难受害者鉴定的 SNP 检测方法回顾:为决策者提供成本、时间和性能信息。
IF 1.5 4区 医学 Q2 MEDICINE, LEGAL Pub Date : 2024-07-17 DOI: 10.1111/1556-4029.15585
Katherine Butler Gettings PhD, Andreas Tillmar PhD, Kimberly Sturk-Andreaggi PhD, Charla Marshall PhD

In mass disaster events, forensic DNA laboratories may be called upon to quickly pivot their operations toward identifying bodies and reuniting remains with family members. Ideally, laboratories have considered this possibility in advance and have a plan in place. Compared with traditional short tandem repeat (STR) typing, single nucleotide polymorphisms (SNPs) may be better suited to these disaster victim identification (DVI) scenarios due to their small genomic target size, resulting in an improved success rate in degraded DNA samples. As the landscape of technology has shifted toward DNA sequencing, many forensic laboratories now have benchtop instruments available for massively parallel sequencing (MPS), facilitating this operational pivot from routine forensic STR casework to DVI SNP typing. Herein, we present the commercially available SNP sequencing assays amenable to DVI, we use data simulations to explore the potential for kinship prediction from SNP panels of varying sizes, and we give an example DVI scenario as context for presenting the matrix of considerations: kinship predictive potential, cost, and throughput of current SNP assay options. This information is intended to assist laboratories in choosing a SNP system for disaster preparedness.

在大规模灾难事件中,法医 DNA 实验室可能会被要求迅速将其业务转向确认尸体身份和帮助遗体与家人团聚。理想的情况是,实验室已经提前考虑到这种可能性,并制定了相应的计划。与传统的短串联重复(STR)分型相比,单核苷酸多态性(SNPs)可能更适合这些灾难受害者身份识别(DVI)方案,因为它们的基因组目标大小较小,从而提高了降解 DNA 样本的成功率。随着DNA测序技术的发展,许多法医实验室现在都拥有了可用于大规模并行测序(MPS)的台式仪器,从而促进了从常规法医STR案件工作到DVI SNP分型的操作转移。在本文中,我们介绍了可用于 DVI 的商用 SNP 测序方法,利用数据模拟探讨了不同规模 SNP 面板的亲缘关系预测潜力,并举例说明了 DVI 情景,以此为背景介绍了考虑因素矩阵:亲缘关系预测潜力、成本和当前 SNP 测定选项的吞吐量。这些信息旨在帮助实验室选择用于备灾的 SNP 系统。
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引用次数: 0
期刊
Journal of forensic sciences
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