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An exceptional case of sudden death due to pseudo-Meigs syndrome 假性梅格斯综合症猝死的特例
IF 1.8 4区 医学 Q2 MEDICINE, LEGAL Pub Date : 2025-09-01 DOI: 10.1111/1556-4029.70175
Lorenzo Gitto MD

Pseudo-Meigs syndrome is a rare clinical entity characterized by the triad of ascites, pleural effusion, and a benign pelvic tumor other than an ovarian fibroma. Although typically considered benign and reversible following tumor removal, the syndrome can result in severe life-threatening compromise if unrecognized or untreated. Unlike the classical Meigs syndrome, which has occasionally been associated with fatal outcomes, no deaths related to pseudo-Meigs syndrome due to benign tumors have been previously reported. This report presents the sudden death of a young adult woman who complained of acute shortness of breath and died shortly thereafter. Postmortem examination revealed more than 2.5 L of serous fluid within the thoracic and abdominal cavities, severe pulmonary collapse, and a markedly enlarged uterus containing a large leiomyoma. Histologic evaluation confirmed the tumor as a uterine leiomyoma. The findings observed at autopsy account for the proposed pathophysiologic mechanisms of death, in which impaired gas exchange and increased intrathoracic pressure likely compromised cardiac output, leading to death. These findings support a diagnosis of pseudo-Meigs syndrome with fatal cardiopulmonary consequences. This case represents the first fatality attributed to pseudo-Meigs syndrome associated with a benign tumor. Awareness of this potential outcome is essential for both clinicians and forensic pathologists when evaluating individuals with large benign pelvic tumors and unexplained cavity effusions.

伪meigs综合征是一种罕见的临床症状,其特征是腹水、胸腔积液和卵巢纤维瘤以外的良性盆腔肿瘤。虽然肿瘤切除后通常被认为是良性和可逆的,但如果不及时发现或治疗,该综合征可能导致严重的危及生命的危害。与偶尔与致命结果相关的经典Meigs综合征不同,以前没有因良性肿瘤导致的与伪Meigs综合征相关的死亡报告。本报告报告了一名年轻成年妇女的突然死亡,她抱怨急性呼吸短促,此后不久死亡。尸检显示胸腔和腹腔内有超过2.5升浆液,严重的肺萎陷,子宫明显增大,子宫内有一个大的平滑肌瘤。组织学检查证实为子宫平滑肌瘤。尸检中观察到的结果说明了提出的死亡病理生理机制,其中气体交换受损和胸内压力增加可能会损害心输出量,导致死亡。这些发现支持假性梅格斯综合征的诊断,并伴有致命的心肺后果。本病例是第一例与良性肿瘤相关的假性梅格斯综合征的死亡病例。对于临床医生和法医病理学家来说,在评估大型良性盆腔肿瘤和不明原因腔积液的个体时,认识到这种潜在的结果是必不可少的。
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引用次数: 0
Exploring Dropbox image downloads to iPhone via safari: File system versus camera roll validation study 通过safari探索Dropbox图像下载到iPhone:文件系统与相机胶卷验证研究。
IF 1.8 4区 医学 Q2 MEDICINE, LEGAL Pub Date : 2025-09-01 DOI: 10.1111/1556-4029.70173
Alexander E. Nash BA, Tierney Moe BS, Gregory S. Wales DFS

This study evaluated the forensic integrity of digital images transferred from Dropbox to iPhones via Safari, a practical scenario for evidence collection when specialized tools are unavailable. Using a quantitative, quasi-experimental design, we analyzed 60 images across three iPhones (running iOS 14.2 and 14.4) to compare downloads to the Files folder and the Photos application. Controlled tests validated measurement sensitivity, while results revealed consistent image content integrity: cryptographic Secure Hash Algorithm 256 (SHA256) stream hashes matched control copies (100%), confirming unchanged pixel data. Additionally, Multiscale Structural Similarity Index (MS-SSIM) scores remained at 1.0, indicating no perceptible degradation in image quality. However, file container hashes were altered within the Photos application (100%) but remained unchanged in the Files folder (0%), reflecting iOS structural modifications. Uniform MS-SSIM scores precluded meaningful regression analysis. Based on our test conditions, the findings suggest forensic workflows comply with standards like Daubert because the transfer preserves content integrity. Limited to specific configurations, future work should explore diverse iOS versions, cloud platforms, and devices for broader applicability.

本研究评估了通过Safari从Dropbox传输到iphone的数字图像的法医完整性,这是在没有专业工具时收集证据的实际情况。我们采用了一种定量的准实验设计,分析了三台iphone(分别运行iOS 14.2和14.4)上的60张图片,比较了Files文件夹和Photos应用程序的下载量。受控测试验证了测量灵敏度,而结果显示了一致的图像内容完整性:加密安全哈希算法256 (SHA256)流哈希匹配控制副本(100%),确认未改变的像素数据。此外,多尺度结构相似指数(MS-SSIM)得分保持在1.0,表明图像质量没有明显下降。然而,在照片应用程序中,文件容器哈希值被改变了(100%),但在Files文件夹中保持不变(0%),这反映了iOS的结构修改。统一的MS-SSIM评分排除了有意义的回归分析。根据我们的测试条件,结果表明取证工作流程符合像Daubert这样的标准,因为传输保持了内容的完整性。限于特定的配置,未来的工作应该探索不同的iOS版本、云平台和设备,以获得更广泛的适用性。
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引用次数: 0
Forensic investigative genetic genealogy and public trust 法医调查基因谱系和公众信任。
IF 1.8 4区 医学 Q2 MEDICINE, LEGAL Pub Date : 2025-08-31 DOI: 10.1111/1556-4029.70167
Jacklyn M. Dahlquist MPH, Christi J. Guerrini JD, MPH, Jill O. Robinson MA, Whitney Bash-Brooks MPH, Amy L. McGuire JD, PhD, Stephanie M. Fullerton DPhil

Forensic Investigative genetic genealogy (FIGG) is a technique used to help identify the source of crime scene DNA or other unknown DNA sources. FIGG is a relatively new practice with several controversial aspects and relies on patchwork regulation in the United States. Two recent studies evaluated FIGG implementation and its public reception; this commentary summarizes and compares the findings of each in a discussion of the importance of public perspectives to evolving policy and practice. These recent empirical reports support new approaches to maintaining public trust in FIGG, including practitioner accreditation and certification, as well as educating and involving the public in further development of the field.

法医调查基因谱系(FIGG)是一种用于帮助识别犯罪现场DNA来源或其他未知DNA来源的技术。FIGG是一种相对较新的做法,有几个有争议的方面,并依赖于美国拼凑的监管。最近的两项研究评估了FIGG的实施情况及其公众接受程度;这篇评论总结并比较了在讨论公众观点对不断发展的政策和实践的重要性时每个人的发现。这些最近的实证报告支持维持公众对FIGG信任的新方法,包括从业人员认证和认证,以及教育和让公众参与该领域的进一步发展。
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引用次数: 0
Unmasking anti-forensic techniques: A DCNN-driven approach to uncover contrast enhancement and median filtering detection 揭露反取证技术:一种dcnn驱动的方法来揭露对比度增强和中值滤波检测。
IF 1.8 4区 医学 Q2 MEDICINE, LEGAL Pub Date : 2025-08-31 DOI: 10.1111/1556-4029.70161
Neeti Taneja ME, Gouri Sankar Mishra PhD, Dinesh Bhardwaj PhD

A forensic analyst must utilize a variety of artifacts in order to create a potent forensic method. By eliminating these artifacts, anti-forensic approaches seek to elude forensic detectors. The field of digital image forensics has many difficulties due to the growing sophistication of anti-forensic tactics. Two popular techniques for modifying image characteristics are contrast enhancement and median filtering, which are frequently used to hide signs of manipulation. Therefore, a solution for identifying anti-forensic techniques is urgently needed. This paper presents a multi-class forensic Deep Convolutional Neural Network (DCNN) architecture that combines domain-specific feature streams and residual-domain pre-processing. This pre-processing is designed to reduce image content and highlight manipulation artifacts in order to detect and classify various kinds of image alterations. The DCNN is made to recognize and extract minute manipulation artifacts that are hidden in pixel-level patterns and invisible to the naked eye. The Boss Base dataset is used for training and testing. Experimental assessments show that the proposed model can recognize images that have been exposed to median filtering and contrast enhancement anti-forensics with a good accuracy of 96.42%, even with different levels of manipulation intensity. The proposed model integrates intelligent pre-processing with domain-tailored streams, which makes it robust against compression and is capable of distinguishing between a wide range of complex manipulation types. This strategy fulfills the increasing demand for automated and precise detection techniques in the fight against anti-forensic activities by offering a reliable tool to digital forensic investigators.

法医分析人员必须利用各种各样的工件来创建有效的法医方法。通过消除这些伪影,反取证方法试图避开取证探测器。由于反取证策略的日益复杂,数字图像取证领域面临着许多困难。修改图像特征的两种常用技术是对比度增强和中值滤波,它们经常被用来隐藏操纵的迹象。因此,迫切需要一种识别反法医技术的解决方案。提出了一种结合特定领域特征流和残差域预处理的多类取证深度卷积神经网络(DCNN)体系结构。这种预处理的目的是减少图像内容和突出操作伪影,以便检测和分类各种图像变化。DCNN用于识别和提取隐藏在像素级模式中且肉眼看不见的微小操纵伪影。Boss Base数据集用于训练和测试。实验评估表明,即使在不同的操作强度下,该模型也能识别出经过中值滤波和对比度增强反取证的图像,准确率达到96.42%。该模型将智能预处理与领域定制流集成在一起,使其具有抗压缩的鲁棒性,并且能够区分各种复杂的操作类型。该策略通过为数字法医调查人员提供可靠的工具,满足了在打击反法医活动中对自动化和精确检测技术日益增长的需求。
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引用次数: 0
The Homicide Offender Motive Scale (HOMS): A classification system for homicide motives based on a qualitative systematic review 杀人罪犯动机量表(HOMS):基于定性系统回顾的杀人动机分类系统。
IF 1.8 4区 医学 Q2 MEDICINE, LEGAL Pub Date : 2025-08-31 DOI: 10.1111/1556-4029.70170
John-Christopher A. Finley MS, Nisha Sen-Gupta MA, Robert E. Hanlon PhD

Many types of homicide motives have been described in the scientific literature. However, inconsistencies regarding how these motives are defined and classified may hinder the ability to understand the driving factors behind homicide. Developing a classification system that defines and organizes commonly used motives into superordinate categories may improve research focused on homicide. The current study sought to develop such a classification system, titled the Homicide Offender Motive Scale (HOMS), based on a qualitative systematic review. Databases including Medline, PsychINFO, and Google Scholar were reviewed to identify all homicide motive studies published prior to February 2024. Multiple reviewers independently assessed the quality of the studies using an empirical appraisal checklist. Seventy-seven studies comprising 143 motives with varying definitions were included. The reviewers then conducted a thematic analysis to identify descriptive and analytical themes for the 143 motives described in the studies. Following empirical guidelines, the motives were synthesized into 21 descriptive themes with operational definitions and criteria. Perfect interrater reliability of these definitions and criteria was then established in an independent sample of 200 adult homicide offenders. Finally, the 21 descriptive themes were grouped into four distinct analytical themes, which were also partly based on an existing criminological classification system. The 21 descriptive themes represent commonly observed motives across different homicide cases. The four analytical themes are superordinate categorizations of the specific motives. The empirical nature of the HOMS may offer a unified typology of homicide motive for researchers to expand upon.

科学文献中描述了许多类型的杀人动机。然而,关于这些动机如何定义和分类的不一致可能会阻碍理解杀人背后驱动因素的能力。开发一种分类系统,将常用的动机定义和组织成更高级的类别,可能会提高对杀人案的研究。目前的研究试图建立这样一个分类系统,标题为杀人罪犯动机量表(HOMS),基于定性的系统回顾。对Medline、PsychINFO和b谷歌Scholar等数据库进行了审查,以确定2024年2月之前发表的所有杀人动机研究。多名审稿人使用经验评估清单独立评估研究的质量。77项研究包括143种不同定义的动机。然后,审稿人进行了主题分析,以确定研究中描述的143个动机的描述性和分析性主题。根据经验指导方针,动机被合成为21个具有操作定义和标准的描述性主题。然后在200名成年杀人罪犯的独立样本中建立了这些定义和标准的完美互译可靠性。最后,将21个描述性主题分为四个不同的分析主题,这些主题也部分基于现有的犯罪学分类系统。21个描述性主题代表了不同凶杀案中常见的动机。这四个分析主题是对具体动机的高级分类。HOMS的经验性质可能为研究人员提供一个统一的杀人动机类型学。
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引用次数: 0
Indoor cats scavenging behind closed doors 室内猫在关着的门后觅食。
IF 1.8 4区 医学 Q2 MEDICINE, LEGAL Pub Date : 2025-08-27 DOI: 10.1111/1556-4029.70172
Mariko Kazuta MD, Shuuji Namiki DDS, Kazuhiro Sakaue PhD, Robert W. Mann PhD, Kana Unuma MD

We report a rare case of postmortem scavenging by cats in Japan involving the skeletonized remains of a woman in her 80s discovered in a locked, garbage-filled room. The body was missing many bones, including vertebrae other than the atlas with odontoid process. The remaining bones were extensively damaged, with destruction of the zygomatic arches, mastoid processes, vertebral facets of the atlas (C1), and epiphyses of the long bones. The bones showed distinctive features such as punctures, denticulated edges, and narrow grooves, consistent with felid dentition. Notably, the damage extended beyond soft tissue consumption, indicating scavenging behavior likely driven by extreme starvation. No evidence of scavenging by canines or rodents was observed, and this case highlights the forensic challenges in identifying postmortem scavengers. This is a well-documented, yet extreme, case of scavenging by cats causing extensive bone destruction. These findings provide valuable insight for future investigations with a long death–postmortem interval and advanced decomposition in domestic environments.

我们报道了日本一个罕见的猫死后食腐的案例,在一个锁着的、堆满垃圾的房间里发现了一个80多岁的女人的骨架。尸体缺了很多骨头,包括除了寰椎和齿状突以外的椎骨。其余骨骼大面积受损,包括颧弓、乳突、寰椎(C1)椎面和长骨骨骺。这些骨头显示出明显的特征,如刺孔、齿状边缘和狭窄的凹槽,与野地齿状一致。值得注意的是,损伤超出了软组织的消耗,表明食腐行为可能是由极度饥饿驱动的。没有观察到犬科动物或啮齿类动物食腐的证据,这一案例突出了鉴定死后食腐动物的法医挑战。这是一个有充分记录的极端案例,猫的食腐造成了大面积的骨骼破坏。这些发现为未来的研究提供了有价值的见解与较长的死亡-尸检间隔和在家庭环境中的高级分解。
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引用次数: 0
Elucidating the etiology of idiopathic spontaneous intraperitoneal hemorrhage 特发性自发性腹膜内出血的病因分析。
IF 1.8 4区 医学 Q2 MEDICINE, LEGAL Pub Date : 2025-08-25 DOI: 10.1111/1556-4029.70160
Dalibor Kovařík MD, Štěpánka Pohlová Kučerová MD, PhD, BSc, Lenka Zátopková MD, PhD, Petr Hejna prof, MD, PhD, MBA, Martin Janík Assoc. prof, MD, PhD

Free blood within the abdominal cavity (hemoperitoneum) presents a significant diagnostic and interpretive challenge. It may result from trauma or occur spontaneously in association with underlying disease conditions. When no source of fatal hemorrhage is identified, the implications extend across forensic, criminalistic, legal, and ethical domains. Idiopathic spontaneous intraperitoneal hemorrhage (ISIH), historically known as abdominal apoplexy, is characterized by fatal hemoperitoneum in the absence of trauma or known nontraumatic causes of intraabdominal bleeding. Rupture of a small intraabdominal vessel is suspected; however, the bleeding source usually remains unidentified. We report the case of a 45-year-old female with cirrhosis who succumbed to ISIH. Autopsy revealed massive hemoperitoneum and signs of exsanguination. Careful dissection of the abdominal cavity identified hemorrhagic ectopic venous varices beneath the right diaphragmatic arch, covered by an organized blood clot. Histological analysis confirmed recent hemorrhage and demonstrated suspected rupture of the parietal peritoneum near dilated ectopic venous varices. This case is evaluated in the context of pathophysiology, etiological theories, diagnostic limitations, potential contributions of imaging modalities, and forensic relevance. To our knowledge, this is the first reported case of ISIH with dual confirmation—both gross and histological—of hemorrhage originating from ectopic varices. These findings testify that rupture of ectopic venous varices may cause fatal hemorrhage in patients with cirrhosis and underscore the necessity of meticulous autopsy and histopathological correlation.

腹腔内的游离血(腹膜血)提出了一个重要的诊断和解释挑战。它可能是由创伤引起的,也可能是与潜在疾病有关的自发发生的。当无法确定致命出血的来源时,其影响将扩展到法医、犯罪学、法律和伦理领域。特发性自发性腹腔出血(ISIH),历史上称为腹腔中风,其特征是在没有创伤或已知的非创伤性腹腔出血原因的情况下发生致死性腹腔出血。怀疑腹腔内小血管破裂;然而,出血的来源通常是不明的。我们报告的情况下,45岁女性肝硬化谁死于ISIH。尸检显示有大量腹膜出血和失血迹象。仔细解剖腹腔,发现右膈弓下有出血性异位静脉曲张,被有组织的血凝块覆盖。组织学分析证实近期出血,并显示疑似腹膜壁破裂附近扩张异位静脉曲张。本病例在病理生理学、病因学理论、诊断局限性、成像方式的潜在贡献和法医相关性的背景下进行评估。据我们所知,这是第一例有肉眼和组织学双重证实的ISIH,出血起源于异位静脉曲张。这些发现证明了异位静脉曲张破裂可能导致肝硬化患者的致命性出血,并强调了细致尸检和组织病理学相关性的必要性。
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引用次数: 0
Correction to “The development of two fast genotyping assays for the differentiation of hemp from marijuana” 更正“两种快速区分大麻和大麻基因分型方法的建立”。
IF 1.8 4区 医学 Q2 MEDICINE, LEGAL Pub Date : 2025-08-24 DOI: 10.1111/1556-4029.70168

Cheng Y-C, Houston R. “The development of two fast genotyping assays for the differentiation of hemp from marijuana”. J Forensic Sci. 2025;70(1):49–60. https://doi.org/10.1111/1556-4029.15663

In TABLE 4, the data in the Final conc. (μM) were incorrect. The correct table appears below.

We apologize for this error.

程永成,休斯顿R.“两种快速基因分型方法的发展用于大麻和大麻的鉴别”。法医学学报,2025;70(1):49-60。https://doi.org/10.1111/1556-4029.15663In表4,Final conc中的数据。(μM)错误。正确的表如下所示。我们为这个错误道歉。
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引用次数: 0
Commentary on: Sağlam İ, Aslan R, Akgür SA, Kurtulmuş Y. Abuse of gabapentinoids in individuals with substance use disorders. J Forensic Sci. 2025;70(3):1125–32. doi: 10.1111/1556-4029.70028 评论:Sağlam İ, Aslan R, akg<e:1> R SA, kurtulmuki Y.加巴喷丁类药物在物质使用障碍个体中的滥用。司法科学,2015;70(3):1125-32。doi: 10.1111 / 1556 - 4029.70028
IF 1.8 4区 医学 Q2 MEDICINE, LEGAL Pub Date : 2025-08-24 DOI: 10.1111/1556-4029.70163
Josef Finsterer MD, PhD
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引用次数: 0
Obstructive coronary ostial thromboemboli mimicking vegetation 阻塞性冠状动脉口血栓栓子模拟植被。
IF 1.8 4区 医学 Q2 MEDICINE, LEGAL Pub Date : 2025-08-20 DOI: 10.1111/1556-4029.70159
Chandini C. Nair MBBS, Ajay Balachandran MD, Anjana Menon P MD, Febby K. Philip MD, Mini Bhaskara Shenoy MD

Sudden cardiac death (SCD) in adolescents is rare and often attributed to previously undiagnosed cardiac conditions, including genetic cardiomyopathies, congenital anomalies, conduction disorders, or thrombotic events. In atypical cases, intracardiac or vascular thromboembolism may resemble vegetations, posing a diagnostic challenge during postmortem evaluation. Thorough investigation, including histopathological analysis, is critical to accurately determine the cause of death. We report the case of a 14-year-old girl who experienced acute chest pain and vomiting shortly after school. Although she received immediate emergency care, she collapsed and passed away within hours. She had a history of occasional chest pain, but prior cardiac evaluations had been normal. The autopsy revealed soft, vegetation-like masses blocking both coronary ostia, raising suspicion of several potential underlying conditions. The differential diagnosis includes infective endocarditis, nonbacterial thrombotic endocarditis, thromboembolus formation, cardiac tumors, vasculitis, and iatrogenic causes. There was no evidence of infection or other common predisposing factors for the thromboembolism. The patient had been fasting during Ramadan, raising the possibility of dehydration and increased blood viscosity as contributing factors. This case highlights the potential for coronary thromboembolism to mimic vegetations. Histopathological examination can yield crucial insights that aid in establishing an accurate diagnosis. SCD in adolescents, particularly in the absence of known risk factors, warrants a comprehensive medicolegal autopsy to uncover underlying or contributing pathologies. Accurate differentiation between thromboembolism and vegetations is essential for correct diagnosis, understanding of pathophysiology, and prevention strategies.

心源性猝死(SCD)在青少年中很少见,通常归因于先前未诊断的心脏疾病,包括遗传性心肌病、先天性异常、传导障碍或血栓事件。在非典型病例中,心内或血管血栓栓塞可能类似于植物,在死后评估时提出诊断挑战。彻底的调查,包括组织病理学分析,是准确确定死亡原因的关键。我们报告的情况下,14岁的女孩谁经历了急性胸痛和呕吐后不久放学。尽管她得到了紧急护理,但她还是在几小时内昏倒并去世了。她有偶尔胸痛的病史,但之前的心脏检查正常。尸检显示软的植物样肿块阻塞了两个冠状动脉口,引起了对几种潜在疾病的怀疑。鉴别诊断包括感染性心内膜炎、非细菌性血栓性心内膜炎、血栓栓子形成、心脏肿瘤、血管炎和医源性原因。没有证据表明感染或其他常见的诱发血栓栓塞的因素。这名患者在斋月期间一直在禁食,这增加了脱水和血液黏稠度增加的可能性。这个病例强调了冠状动脉血栓栓塞的可能性。组织病理学检查可以产生关键的见解,有助于建立准确的诊断。青少年SCD,特别是在缺乏已知危险因素的情况下,需要进行全面的法医解剖,以发现潜在或促成的病理。准确区分血栓栓塞和植被对于正确诊断、理解病理生理学和预防策略至关重要。
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引用次数: 0
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Journal of forensic sciences
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