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Estimation of Electric Dipole Moment by Solvatochromism, Computational Method, and Study of the Effect of Solvents by Preferential Solvation of 6 - Methoxy-4-(4-Nitro-Phenoxy Methyl)-Chromen-2-One (6mnpm). 利用溶色法、计算法估算电偶极矩,以及通过优先溶解 6-甲氧基-4-(4-硝基-苯氧基甲基)-2-苯并吡喃酮 (6mnpm) 研究溶剂的影响。
IF 2.6 4区 化学 Q2 BIOCHEMICAL RESEARCH METHODS Pub Date : 2024-10-04 DOI: 10.1007/s10895-024-03955-8
Srinath, Omnath Patil, Sulochana Devar, S M Hanagodimath

At room temperature, the absorption and fluorescence properties of coumarin 6-Methoxy-4-(4-nitro-phenoxy methyl)-chromen-2-one (6MNPM) are investigated in pure organic solvents and a combination of acetonitrile (ACN) and tetrahydrofuran (THF). The pure solvents' influence on spectral characteristics is examined by applying theories such as Kamlet and Catalan's multiple linear regression techniques, Reichardt's microscopic solvent polarity parameter, and the Lippert-Mataga polarity function. The significant role of solute-solvent interactions in pure solvents, particularly dielectric interaction and hydrogen bonding. However, hydrogen bonding interactions dominate the contribution of dielectric interactions. The electric dipole moments of both the ground as well as excited states had been calculated using the Solvatochromic method. The value of the excited state electric dipole moment and the redshifts of the emission spectra show that the emitting singlet state has an intramolecular charge transfer (ICT) character. From Catalan's linear regression, we found that di-polarity has a much smaller influence than polarizability. By solvation study, we conclude that Tetrahydrofuran solvent is preferred over Acetonitrile.

室温下,研究了香豆素 6-甲氧基-4-(4-硝基-苯氧基甲基)-苯并吡喃-2-酮(6MNPM)在纯有机溶剂以及乙腈(ACN)和四氢呋喃(THF)混合溶剂中的吸收和荧光特性。通过应用 Kamlet 和 Catalan 的多元线性回归技术、Reichardt 的微观溶剂极性参数和 Lippert-Mataga 极性函数等理论,研究了纯溶剂对光谱特性的影响。在纯溶剂中,溶剂与溶剂之间的相互作用,尤其是介电相互作用和氢键作用,起着重要作用。然而,氢键相互作用在介电相互作用的贡献中占主导地位。利用 Solvatochromic 方法计算了基态和激发态的电偶极矩。激发态电偶极矩的值和发射光谱的红移表明,发射单态具有分子内电荷转移(ICT)特性。通过卡塔兰线性回归,我们发现二极性比极化性的影响要小得多。通过溶解研究,我们得出结论,四氢呋喃溶剂比乙腈更受青睐。
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引用次数: 0
A New Powerful Magnetic Dark Catalyst Based on rGO/Fe3O4/CdSe Nanocomposite for Ultrafast Degradation of Methylene Blue Dye. 基于 rGO/Fe3O4/CdSe 纳米复合材料的新型强力磁性暗催化剂用于超快降解亚甲基蓝染料。
IF 2.6 4区 化学 Q2 BIOCHEMICAL RESEARCH METHODS Pub Date : 2024-10-03 DOI: 10.1007/s10895-024-03982-5
Afrasiab Salehi Moghanlou, Mehdi Molaei, Tao Fang

In the present study, Rgo/Fe3O4/CdSe as a dark catalyst material was synthesized by a refluxing method. The synthesized magnetic nanocomposites were studied by various analyses such as Fourier transform infrared (FTIR), energy-dispersive X-ray spectroscopy (EDS), field emission scanning electron microscopy (FESEM), X-ray diffractometer (XRD), Raman, Zeta and vibrating sample magnetometer (VSM). Characterization of structural analysis showed that the nanocomposites were successfully synthesized. The absorption spectrum was used to determine the dark catalyst activity of rGO/Fe3O4/CdSe nanocomposite. Analysis of the absorption spectrum showed that the prepared nanocomposites degrade the MB organic dye completely (100%) after 2 min of stirring in the dark, also experimenting with different pH showed that the best performance for the degradation of MB occurs in neutral and alkaline media. The Raman spectrum analysis showed that the Fe3O4/CdSe quantum dots (QDs) were correctly incorporated on the reduced graphene oxide (rGO) nanosheets. Zeta potential analysis showed that rGO/Fe3O4/CdSe has a large amount of negative charge on its surface and the surface charge increased by about 16 mV compared to the Fe3O4/CdSe compound. BET and BJH techniques were used to determine the effective surface area and pore size diameter, BET results to determine the effective surface area showed that by adding graphene to the compound, the specific surface area increased from 42.877 m2g-1 to 54.1896 m2g-1. The radical scavenger experiment showed that electrons play an essential role in the degradation process. VSM analysis showed that the prepared nanocomposites have excellent superparamagnetic behavior, this advantage enables the easy collection of nanocatalysts by magnets from wastewater after dye degradation.

本研究采用回流法合成了 Rgo/Fe3O4/CdSe 作为暗催化剂材料。通过傅立叶变换红外光谱(FTIR)、能量色散 X 射线光谱(EDS)、场发射扫描电子显微镜(FESEM)、X 射线衍射仪(XRD)、拉曼光谱、Zeta 和振动样品磁力计(VSM)等多种分析方法对合成的磁性纳米复合材料进行了研究。结构分析表明成功合成了纳米复合材料。吸收光谱用于测定 rGO/Fe3O4/CdSe 纳米复合材料的暗催化剂活性。吸收光谱分析表明,所制备的纳米复合材料在暗处搅拌 2 分钟后可完全(100%)降解 MB 有机染料,不同 pH 值的实验也表明,在中性和碱性介质中降解 MB 的性能最佳。拉曼光谱分析表明,Fe3O4/CdSe 量子点(QDs)正确地结合在还原氧化石墨烯(rGO)纳米片上。Zeta 电位分析表明,rGO/Fe3O4/CdSe 表面带有大量负电荷,与 Fe3O4/CdSe 复合物相比,表面电荷增加了约 16 mV。BET 和 BJH 技术用于测定有效表面积和孔径,BET 测定有效表面积的结果显示,在化合物中加入石墨烯后,比表面积从 42.877 m2g-1 增加到 54.1896 m2g-1。自由基清除剂实验表明,电子在降解过程中起着至关重要的作用。VSM 分析表明,所制备的纳米复合材料具有优异的超顺磁性,这一优点使得磁铁可以轻松地从染料降解后的废水中收集纳米催化剂。
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引用次数: 0
Temperature-Driven Stopped-Flow Experiments for Investigating the Initial Aggregation of the α-Synuclein Amyloid Protein, Focusing on Active and Inactive Phases. 用于研究α-突触核蛋白淀粉样蛋白初始聚合的温度驱动停流实验,重点关注活性和非活性相。
IF 2.6 4区 化学 Q2 BIOCHEMICAL RESEARCH METHODS Pub Date : 2024-10-02 DOI: 10.1007/s10895-024-03971-8
Marco A Saraiva

The primary objective of this research is to further examine the events occurring during the active or burst phase by focusing on the aggregation of the Syn amyloid protein. Regarding this aspect, it was initially conducted rapid temperature variations using stopped-flow spectrometry and tyrosyl group fluorescence emission detection, within the initial 500 milliseconds in buffered Syn solutions at pH 7, exploring various temperature ranges to investigate protein aggregation. The results obtained were contrasted with results obtained for the Nα-acetyl-L-tyrosinamide (NAYA) parent compound in the same conditions. The utilization of the NAYA compound is suitable as it mimics the peptide bonds in proteins and contains a tyrosyl group resembling the four tyrosyl groups found in the Syn protein structure (the protein has no tryptophan residues). Furthermore, the NAYA compound adopts an intramolecularly hydrogen-bonded structure even in an aqueous solution, similar to the interactions seen in the hydrophilic face of β-sheets. Additionally, the Syn protein system can exhibit the presence of β-sheets as a result of the existence of very low abundant Syn amyloid precursor forms or nuclei during the initial stages of the protein aggregation. Thus, a relationship is present between the molecular processes in the NAYA and Syn protein systems, making the NAYA's application crucial in this research. Moreover, to aid in understanding the results, it was also compared the events during the quiescent or inactive phase (30-500 milliseconds) with those in the burst phase (up to 10 milliseconds) using stopped-flow spectrometry conditions. Steady-state measurements were beneficial in comprehending the occurrences in both the quiescent and burst phases examined. Although protein aggregation and disaggregation were observed during the quiescent phase, determining these processes in the burst phase was more challenging. In the latter case, the aggregation of the Syn protein is actually initiated by the interaction of the intrinsically disordered Syn monomers. In the quiescent phase, first-order rate constants were measured and analysis showed that Syn protein aggregation and disaggregation occur simultaneously. At lower temperatures, early protein disaggregation outweighs protein aggregation whereas at higher temperatures protein disaggregation and aggregation are rather similar. It is also need to highlight that the burst phase, while distinct from the quiescent phase, can be considered as a possible structural phase for obtaining details about the aggregation of this specific disordered protein in solution on a very short timescale.

这项研究的主要目的是通过关注 Syn 淀粉样蛋白的聚集,进一步研究在活性或爆发阶段发生的事件。在这方面,研究人员首先使用停流光谱仪和酪氨酰基荧光发射检测技术,在 pH 值为 7 的缓冲 Syn 溶液中的最初 500 毫秒内进行快速温度变化,探索各种温度范围以研究蛋白质的聚集情况。获得的结果与 Nα- 乙酰基-L-酪氨酰胺(NAYA)母体化合物在相同条件下获得的结果进行了对比。使用 NAYA 化合物是合适的,因为它模仿了蛋白质中的肽键,并含有一个与 Syn 蛋白结构中的四个酪氨酰基相似的酪氨酰基(蛋白质中没有色氨酸残基)。此外,即使在水溶液中,NAYA 化合物也能形成分子内氢键结构,类似于 β 片层亲水面的相互作用。此外,在蛋白质聚集的初始阶段,由于存在含量极低的 Syn 淀粉样蛋白前体或核,Syn 蛋白系统也会显示出 β 片层的存在。因此,NAYA 和 Syn 蛋白系统中的分子过程之间存在着某种关系,这使得 NAYA 在本研究中的应用变得至关重要。此外,为了帮助理解研究结果,研究人员还利用停流光谱条件比较了静态或非活动期(30-500 毫秒)与爆发期(最多 10 毫秒)的事件。稳态测量有利于理解静态和爆发阶段的事件。虽然在静止期观察到了蛋白质聚集和分解,但在爆发期确定这些过程更具挑战性。在后一种情况下,Syn 蛋白的聚集实际上是由本质上无序的 Syn 单体相互作用引发的。在静止阶段,测量了一阶速率常数,分析表明 Syn 蛋白的聚集和分解是同时发生的。在较低温度下,早期蛋白质的解聚大于蛋白质的聚集,而在较高温度下,蛋白质的解聚和聚集相当接近。还需要强调的是,尽管猝灭阶段有别于静止阶段,但可以将其视为一种可能的结构阶段,以便在极短的时间尺度内获得这种特定无序蛋白质在溶液中聚集的细节。
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引用次数: 0
Influence of Viscosity and Temperature on Rotational Dynamics of 3-(1H-benzo[d]Imidazol-2-yl)-7-(Diethyl Amino)-2H-chromen-2-one (Polar Laser dye) in Highly Viscous Solvent: Low and High Viscous Range. 粘度和温度对高粘度溶剂中 3-(1H-苯并[d]咪唑-2-基)-7-(二乙基氨基)-2H-色烯-2-酮(极性激光染料)旋转动力学的影响:低粘度和高粘度范围。
IF 2.6 4区 化学 Q2 BIOCHEMICAL RESEARCH METHODS Pub Date : 2024-10-02 DOI: 10.1007/s10895-024-03951-y
Anil Kumar, C G Renuka

Temperature-dependent rotational dynamics of 3-(1 H-benzo[d]imidazol-2-yl)-7-(diethyl amino)-2 H-chromen-2-one (3HBI-7D-2HChromen-2-one) has been studied in highly viscous glycerol solvent. Over the entire studied temperature range rotational reorientation time values vary linearly with temperature. Experimental obtained rotational results are analyzed using hydrodynamic and quasi-hydrodynamic models over the entire temperature range as well as low and high viscous range. 3HBI-7D-2HChromen-2-one rotational dynamics has been described using Stoke's-Einstein-Debye (SED) slip boundary conditions.

研究人员在高粘度甘油溶剂中研究了 3-(1H-苯并[d]咪唑-2-基)-7-(二乙基氨基)-2H-色烯-2-酮(3HBI-7D-2HChromen-2-one)随温度变化的旋转动力学。在整个研究温度范围内,旋转重新定向时间值随温度呈线性变化。在整个温度范围以及低粘度和高粘度范围内,使用流体力学和准流体力学模型对实验获得的旋转结果进行了分析。使用斯托克-爱因斯坦-德贝(SED)滑移边界条件描述了 3HBI-7D-2HChromen-2-one 旋转动力学。
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引用次数: 0
A Novel Rhodamine B Derivative as a "Turn-on" Fluorescent Sensor for Cu2+ with High Selectivity and Sensitivity. 一种新型罗丹明 B 衍生物作为 Cu2+ 的 "开启式 "荧光传感器,具有高选择性和高灵敏度。
IF 2.6 4区 化学 Q2 BIOCHEMICAL RESEARCH METHODS Pub Date : 2024-10-02 DOI: 10.1007/s10895-024-03977-2
Li Liu, Tao Zhou, Yawen Li, Tianrong Li

The number of "turn-on" fluorescent probes for Cu2+ is relatively limited, and interference from other metal cations presents a significant challenge for these sensors. In this study, we synthesized and characterized a rhodamine B-based sensor, designated as RBHP, using 1-phenyl-3-methyl-4-benzoyl-5-pyrazolone (PMBP) and rhodamine B hydrazide. Selectivity, sensitivity, solvent effects, water content, and pH of RBHP in relation to Cu²⁺ were conducted. RBHP exhibited an exceptionally low fluorescence background signal in acetonitrile and demonstrated a "turn-on" fluorescent response to Cu²⁺. The PMBP-based acylhydrazone moiety and acetonitrile as the detection solvent are crucial for the selective detection. RBHP shows potential as a highly selective and sensitive fluorescent sensor for Cu2+.

Cu2+ 的 "开启 "荧光探针数量相对有限,而且其他金属阳离子的干扰也给这些传感器带来了巨大挑战。在本研究中,我们利用 1-苯基-3-甲基-4-苯甲酰基-5-吡唑啉酮(PMBP)和罗丹明 B 酰肼合成了一种基于罗丹明 B 的传感器,并对其进行了表征,命名为 RBHP。研究了 RBHP 的选择性、灵敏度、溶剂效应、含水量和 pH 值与 Cu²⁺ 的关系。RBHP 在乙腈中的荧光本底信号特别低,并对 Cu²⁺ 显示出 "开启 "荧光反应。基于 PMBP 的酰腙分子和乙腈作为检测溶剂对于选择性检测至关重要。RBHP 显示出作为 Cu2+ 的高选择性、高灵敏度荧光传感器的潜力。
{"title":"A Novel Rhodamine B Derivative as a \"Turn-on\" Fluorescent Sensor for Cu<sup>2+</sup> with High Selectivity and Sensitivity.","authors":"Li Liu, Tao Zhou, Yawen Li, Tianrong Li","doi":"10.1007/s10895-024-03977-2","DOIUrl":"https://doi.org/10.1007/s10895-024-03977-2","url":null,"abstract":"<p><p>The number of \"turn-on\" fluorescent probes for Cu<sup>2+</sup> is relatively limited, and interference from other metal cations presents a significant challenge for these sensors. In this study, we synthesized and characterized a rhodamine B-based sensor, designated as RBHP, using 1-phenyl-3-methyl-4-benzoyl-5-pyrazolone (PMBP) and rhodamine B hydrazide. Selectivity, sensitivity, solvent effects, water content, and pH of RBHP in relation to Cu²⁺ were conducted. RBHP exhibited an exceptionally low fluorescence background signal in acetonitrile and demonstrated a \"turn-on\" fluorescent response to Cu²⁺. The PMBP-based acylhydrazone moiety and acetonitrile as the detection solvent are crucial for the selective detection. RBHP shows potential as a highly selective and sensitive fluorescent sensor for Cu<sup>2+</sup>.</p>","PeriodicalId":15800,"journal":{"name":"Journal of Fluorescence","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2024-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142361641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Aggregation Behavior of CHR-bis(BODIPY) Bichromophores in THF-water Mixtures: Effect of Linking Positions and Aryl-spacer Substituents. CHR 双(BODIPY)重色团在 THF-水混合物中的聚合行为:连接位置和芳基间隔取代基的影响。
IF 2.6 4区 化学 Q2 BIOCHEMICAL RESEARCH METHODS Pub Date : 2024-10-02 DOI: 10.1007/s10895-024-03980-7
Artem S Sherudillo, Alexander A Kalyagin, Lubov A Antina, Mikhail B Berezin, Elena V Antina

Aggregation-caused quenching effect (ACQ) greatly limits the practical use of many organic luminophores in biomedicine, optics and electronics. The comparative analysis of aggregation characteristics of CHR-bis(BODIPY) bichromophores 1-6 with R = H, Ph, MeOPh and various linking positions (α,α-; α,β-; β,β- and β',β'-) in THF-water mixtures with different water fractions or dye concentrations is first presented in this article. Both the linking style 1-4 and the arylation of the spacer with phenyl (Ph-) 5 or methoxyphenyl (MeOPh-) 6 substituents strongly affect the formation of luminophore aggregated forms in binary THF-water mixtures. The α,α-and β,β-isomers (1 and 3) form non-fluorescent H-type aggregates in THF-water mixtures with fw > 70%. The α,β-; β',β'-isomers (2, 4) and the MeOPh-substituted β,β-bichromophore 6 are characterized by predominant formation fluorescent aggregates. All bichromophores are characterized by the presence of residual amounts of non-aggregated forms in binary mixtures with maximum water content. The results are useful for controlling the aggregation behavior and spectral characteristics of CHR-bis(BODIPY) bichromophores in aqueous-organic media, which is important in the development of biomarkers and PDT agents.

聚集引起的淬灭效应(ACQ)极大地限制了许多有机发光体在生物医学、光学和电子学领域的实际应用。本文首次比较分析了 R = H、Ph、MeOPh 和不同连接位置(α,α-;α,β-;β,β- 和 β',β'-)的 CHR-双(BODIPY)双色素 1-6 在不同水组分或染料浓度的 THF-水混合物中的聚集特性。连接方式 1-4 和间隔物与苯基 (Ph-) 5 或甲氧基苯基 (MeOPh-) 6 取代基的芳基化都会强烈影响二元 THF 水混合物中发光体聚集形式的形成。在 fw > 70% 的四氢呋喃-水混合物中,α,α 和 β,β- 异构体(1 和 3)形成无荧光的 H 型聚集体。α,β-;β',β'-异构体(2、4)和 MeOPh 取代的 β,β-双色团 6 主要形成荧光聚集体。在含水量最大的二元混合物中,所有双色体都存在残余的非聚集形式。研究结果有助于控制 CHR-双(BODIPY)双色素在水有机介质中的聚集行为和光谱特征,这对于开发生物标记物和光导放疗剂非常重要。
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引用次数: 0
Label-Free Detection of Programmed Death-Ligand 1 for Prognosis Using a Truncated Aptamer and SYBR Green I. 使用截短的适配体和 SYBR 绿 I 无标记检测程序性死亡配体 1 以进行预后分析
IF 2.6 4区 化学 Q2 BIOCHEMICAL RESEARCH METHODS Pub Date : 2024-10-01 DOI: 10.1007/s10895-024-03960-x
Ling Li, Zheng-Ling Li, Wei Wang, Xin-Xin Long, Ping Liu, Guo-Tian Wang, Shi-Qing Sun, Rong-Lian Du

The rapid and accurate detection of programmed death-ligand 1 (PD-L1) expression is of great value in the diagnosis and treatment of tumors. ELISA-based traditional method is the gold standard for protein detection, but there are still some shortcomings, especially the antigen-antibody dependence, greatly increased the detection time and cost. This work constructed a label-free fluorescent probe for rapid and sensitive detection of PD-L1 using a truncated aptamer as recognition molecules and double-stranded DNA specific dyes (SYBR Green I) as signal units. After a series of optimization conditions, this probe has good detection capability for PD-L1 in buffer solution with the detection limit as low as 0.68 ng/mL. Due to the specific recognition ability of aptamer and target, this method also has good selectivity for PD-L1 detection. The recovery of PD-L1 in human serum samples ranges from 86.20 to 96.36%. Compared with other methods, this strategy does not need to be marked, and does not need other complex design and purification process, but simple operation process and strong anti-interference ability. The whole detection process can be completed within 20 min and has good application prospect. This work will provide reference for drug dosage and prognosis evaluation of specific tumor therapy.

快速准确地检测程序性死亡配体1(PD-L1)的表达对肿瘤的诊断和治疗具有重要价值。基于ELISA的传统方法是蛋白质检测的金标准,但仍存在一些缺陷,尤其是抗原抗体依赖性,大大增加了检测时间和成本。本研究以截短的aptamer为识别分子,以双链DNA特异性染料(SYBR Green I)为信号单元,构建了一种快速灵敏检测PD-L1的无标记荧光探针。经过一系列条件优化,该探针对缓冲溶液中的 PD-L1 具有良好的检测能力,检测限低至 0.68 ng/mL。由于适配体与目标物的特异性识别能力,该方法对 PD-L1 的检测也具有良好的选择性。人血清样本中 PD-L1 的回收率为 86.20% 至 96.36%。与其他方法相比,该策略无需标记,不需要其他复杂的设计和纯化过程,操作过程简单,抗干扰能力强。整个检测过程可在 20 分钟内完成,具有良好的应用前景。这项工作将为特异性肿瘤治疗的药物剂量和预后评估提供参考。
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引用次数: 0
Laboratory Investigation of Dodecylbenzene Detection in Seawater Via Fluorometric Index of Excitation-emission Matrix Spectra. 通过激发-发射矩阵光谱的荧光指数检测海水中十二烷基苯的实验室研究。
IF 2.6 4区 化学 Q2 BIOCHEMICAL RESEARCH METHODS Pub Date : 2024-10-01 DOI: 10.1007/s10895-024-03978-1
Jianping Liao, Zhifeng Liu, Weiqi Yang, Chen Tian, Xueyu Wu, Zhiping Zhu, Zhenggang Wang

​Oil-filled submarine cables have come to dominate the reliable delivery of electrical power today, but oil leakages still remain a challenge. This work focuses on exploring the detection of dodecylbenzene (DDB) after leakage. DDB can be dispersed as small droplets in seawater, which the diameter of DDB droplets increased from 60 nm to 200 nm with the increase of the concentration from 10 ppm to 1000 ppm. Moreover, excitation-emission matrix (EEM) spectra were employed to investigated the detection of DDB. DDB has characteristic fluorescence peaks located at λExEm = 225/350 and 255/350. The FIo/w value of 50 ppm DDB was 28.869, which was significantly different from simulated seawater low as 1.3926. Contaminants such as metal ions (Cu2+, Cd2+, Zn2+) and organic matter (tetracycline) do not significantly affect the qualitative identification of DDB by EEMs. This study suggests a research basis for exploring the way for detection of DDB.

如今,充油海底电缆已成为可靠输送电力的主要方式,但漏油仍是一项挑战。这项工作的重点是探索泄漏后十二烷基苯(DDB)的检测。十二烷基苯能以小液滴的形式分散在海水中,随着浓度从 10 ppm 增加到 1000 ppm,十二烷基苯液滴的直径从 60 nm 增加到 200 nm。此外,还利用激发-发射矩阵(EEM)光谱研究了 DDB 的检测。DDB 的特征荧光峰位于 λEx/λEm = 225/350 和 255/350。50 ppm DDB 的 FIo/w 值为 28.869,与低至 1.3926 的模拟海水有显著差异。金属离子(Cu2+、Cd2+、Zn2+)和有机物(四环素)等污染物对 EEMs 对 DDB 的定性鉴定没有明显影响。这项研究为探索 DDB 的检测方法提供了研究基础。
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引用次数: 0
Temperature-Dependent Rotational Dynamics of a Polar Probe in Non-Polar Aprotic Solvents: Interplay of Solvent Viscosity and Size Effect. 非极性 Aprotic 溶剂中极性探针随温度变化的旋转动力学:溶剂粘度和尺寸效应的相互作用。
IF 2.6 4区 化学 Q2 BIOCHEMICAL RESEARCH METHODS Pub Date : 2024-10-01 DOI: 10.1007/s10895-024-03973-6
Anil Kumar, C G Renuka

Rotational dynamics of 3-(benzo[d]thiazol-2-yl)-7-(diethylamino)-2 H-chromen-2-one (3BT7D2H-one) probe in non-polar aprotic 1,4 dioxane, toluene and cyclohexane solvents of different and comparable viscosity are studied with varying temperature using steady-state and fluorescence depolarization technique. The experimental reorientation time is compared with the hydrodynamic Stoke's-Einstein-Debye(SED). The experimentally measured rotational reorientation times are higher in 1,4 dioxane attributed to its solvent viscosity. In cyclohexane, the solute rotational dynamics behavior shows a transition from sub-slip to SED slip boundary conditions with varying temperatures. Solvent viscosity, size, and subtle changes in the molecular shape of solute play an important role in the rotational dynamics of polar probes in non-polar aprotic solvents.

利用稳态和荧光去极化技术,研究了 3-(苯并[d]噻唑-2-基)-7-(二乙基氨基)-2 H-色烯-2-酮(3BT7D2H-one)探针在非极性的 1,4-二氧六环、甲苯和环己烷溶剂中的旋转动力学,这些溶剂的粘度不同且相当。实验重新定向时间与流体力学斯托克-爱因斯坦-德拜(SED)进行了比较。在 1,4 二氧六环中,由于溶剂粘度的原因,实验测得的旋转重新定向时间较长。在环己烷中,随着温度的变化,溶质旋转动力学行为显示了从亚滑移到 SED 滑动边界条件的过渡。溶剂粘度、溶质大小和分子形状的微妙变化对极性探针在非极性非质子溶剂中的旋转动力学起着重要作用。
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引用次数: 0
Selective Detection of Picric Acid by Benzodiazepine Containing Enaminone Core as Receptor and Its Application to Real Water Sample Analysis. 以含烯酮核的苯并二氮杂卓为受体选择性检测苦味酸及其在实际水样分析中的应用。
IF 2.6 4区 化学 Q2 BIOCHEMICAL RESEARCH METHODS Pub Date : 2024-10-01 DOI: 10.1007/s10895-024-03925-0
Rajendran Eswaran, Loganathan Selvaraj, Santhiya Ramasamy, Sivaraman Gandhi, Seenivasa Perumal Muthu

Nitroaromatic compounds are highly explosive and illegitimate substances. Over a decade, chemists have been affianced in extensive research on the selective and sensitive detection of these nitroaromatic explosives for homeland security and environmental protection. The benzodiazepine-based enaminone (BDE) receptor has been synthesized by aqueous extract of onion catalyzed three-component reaction between o-phenylenediamine, dimedone with an aldehyde. The BDE probe is well analyzed and applied to a sensor that selectively detects picric acid (PA). UV-Vis and fluorescence spectroscopy were used to investigate the photophysical responses of the receptor (BDE). From the observed results BDE found turn-off fluorescence with the addition of picric acid and the lowest limit of detection and limit of quantification was achieved about 24.6 nM and 73.8 nM. The fluorescence quantum yield was attained about 0.28. The BDE-PA adduct formation was confirmed by 1H NMR titration analysis. The Job's plot analysis was performed through 1H NMR titrations and established the binding stoichiometry ratio of the BDE-PA adduct as 1:1 ratio. Further, DFT calculations supported the observed photophysical responses of BDE-PA adduct to confirm the molecular level interactions. The receptor was effectively applied to approximate level of picric acid in real water sample analysis.

硝基芳香族化合物是极易爆炸的非法物质。十多年来,化学家们一直致力于对这些硝基芳香族爆炸物进行选择性和灵敏检测的广泛研究,以促进国土安全和环境保护。通过洋葱水提取物催化邻苯二胺、二咪酮和醛之间的三组份反应,合成了苯并二氮杂卓基烯酮(BDE)受体。BDE 探针经过良好分析后被应用于选择性检测苦味酸(PA)的传感器。紫外可见光谱和荧光光谱被用来研究受体(BDE)的光物理反应。从观察结果来看,BDE 在加入苦味酸后会熄灭荧光,最低检测限和定量限分别为 24.6 nM 和 73.8 nM。荧光量子产率约为 0.28。1H NMR 滴定分析证实了 BDE-PA 加合物的形成。通过 1H NMR 滴定进行约伯图分析,确定了 BDE-PA 加合物的结合化学计量比为 1:1。此外,DFT 计算支持观察到的 BDE-PA 加合物的光物理反应,从而确认了分子水平的相互作用。该受体被有效地应用于实际水样分析中苦味酸的近似水平。
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Journal of Fluorescence
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