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Women-centric economics: A closer look at gender budgeting in India. 以妇女为中心的经济学:近距离观察印度的性别预算编制。
IF 1.1 Q4 PRIMARY HEALTH CARE Pub Date : 2024-09-01 Epub Date: 2024-09-11 DOI: 10.4103/jfmpc.jfmpc_560_24
Namratha Kulkarni, Pavan P Havaldar

This article explores gender budgeting in Indian healthcare, emphasizing its role in addressing disparities. Examining trends, recent highlights, and implementation, it showcases impacts on maternal health, reproductive services, gender-based violence, and empowerment. Examples such as Ayushman Bharat and Mahila Samman Savings Certificate illustrate economic implications. Beyond healthcare, gender-responsive budgeting is seen as a versatile tool for broader equality. Challenges prompt a call for sustained efforts and a comprehensive framework.

本文探讨了印度医疗保健中的性别预算编制,强调了其在解决差异方面的作用。文章通过对趋势、最新亮点和实施情况的研究,展示了对孕产妇健康、生殖服务、性别暴力和赋权的影响。Ayushman Bharat 和 Mahila Samman 储蓄证等实例说明了其经济影响。除医疗保健外,促进性别平等的预算编制被视为实现更广泛平等的通用工具。挑战促使人们呼吁做出持续努力并建立一个综合框架。
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引用次数: 0
Assessment of burden of prediabetes and diabetes with oral glucose tolerance test in community-based settings of Bengaluru rural district. 在班加罗尔农村地区的社区环境中通过口服葡萄糖耐量测试评估糖尿病前期和糖尿病的负担。
IF 1.1 Q4 PRIMARY HEALTH CARE Pub Date : 2024-09-01 Epub Date: 2024-09-11 DOI: 10.4103/jfmpc.jfmpc_9_24
Gokul Sarveswaran, Vaitheeswaran Kulothungan, Sukanya Rangamani, Deepadarshan Huliyappa, Pruthvish Sreekantaiah

Background and objectives: Diabetes is a major public health concern in India. The majority of studies done in rural population lack systematic methodology in estimating the prevalence of diabetes mellitus. Objectives of this study were to estimate the burden of prediabetes, type 2 diabetes mellitus and its associated risk factors among adults (18-69) years in rural Bengaluru, Karnataka.

Methods: A cross-sectional study was conducted among adults aged 18-69 years in three villages of Devanahalli taluk of rural Bengaluru between May and October 2019. Behavioural and metabolic risk factors related to diabetes were assessed using WHO-STEPS instrument and IDSP-NCD risk factor tool. Fasting blood glucose and OGTT test were performed, and WHO diagnostic criteria were used to diagnose diabetes mellitus.

Results: Prevalence of prediabetes and type 2 diabetes (T2DM) in rural Bengaluru was found to be 6.3% and 10.9%, respectively. Behavioural risk factors related to diabetes measured in the study population were current tobacco use (32.7%), current alcohol use (9.9%), physical inactivity (46.8%) and unhealthy diet (82.3%). Metabolic risk factors measured were obesity (7.5%), central obesity (46.4%), prediabetes (6.3%) and hypertension (24.3%). More than one-thirds of diabetes and three-fourths of hypertension individuals were newly diagnosed by the population-based screening.

Conclusion: The burden of diabetes and its risk factors are high due to the health transition occurring in rural population of Bengaluru. Undiagnosed diabetes mellitus and hypertension in rural population as demonstrated by this study highlight the need to strengthen the population-based screening and diagnosis of T2DM and hypertension (HTN) under the national health programme.

背景和目标:糖尿病是印度的一大公共卫生问题。大多数针对农村人口的研究缺乏系统的方法来估算糖尿病的患病率。本研究的目的是估算卡纳塔克邦班加罗尔农村地区成人(18-69 岁)中糖尿病前期、2 型糖尿病及其相关风险因素的负担:方法:2019 年 5 月至 10 月期间,在班加罗尔农村 Devanahalli taluk 的三个村庄对 18-69 岁的成年人进行了横断面研究。使用 WHO-STEPS 工具和 IDSP-NCD 风险因素工具评估了与糖尿病相关的行为和代谢风险因素。进行了空腹血糖和 OGTT 测试,并使用 WHO 诊断标准诊断糖尿病:结果:发现班加罗尔农村地区糖尿病前期和 2 型糖尿病(T2DM)的患病率分别为 6.3% 和 10.9%。研究人群中与糖尿病相关的行为风险因素包括吸烟(32.7%)、酗酒(9.9%)、缺乏运动(46.8%)和不健康饮食(82.3%)。代谢风险因素包括肥胖(7.5%)、中心性肥胖(46.4%)、糖尿病前期(6.3%)和高血压(24.3%)。超过三分之二的糖尿病患者和四分之三的高血压患者是通过人群筛查新确诊的:结论:由于班加罗尔农村人口的健康转型,糖尿病及其风险因素的负担很重。本研究显示,农村人口中未确诊的糖尿病和高血压突出表明,有必要在国家健康计划中加强对 T2DM 和高血压(HTN)的人群筛查和诊断。
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引用次数: 0
Prevalence of inadequate fruit and vegetable consumption and associated food choice motives among adults in an urban population in Kerala. 喀拉拉邦城市成年人水果和蔬菜摄入不足的普遍程度及相关的食物选择动机。
IF 1.1 Q4 PRIMARY HEALTH CARE Pub Date : 2024-09-01 Epub Date: 2024-09-11 DOI: 10.4103/jfmpc.jfmpc_585_24
Shilpa Sara Abraham, K Sreelakshmi Mohandas

Background: Existing literature does not account for food choice motives associated with the non-communicable disease risk factor of an unhealthy diet, primarily characterised by inadequate fruit and vegetable consumption, among adults residing in Kochi Municipal Corporation. Our study aims to measure the prevalence of inadequate fruit and vegetable consumption in this urban population and to identify priority food choice motives among individuals at risk.

Methods: A community-based cross-sectional study was conducted among 300 adults (mean age 46 years, men 50%) selected by cluster sampling. Information on socio-demographic variables, diet, and food choice motives was collected through a pre-tested structured interview schedule. Binary logistic regression analysis was done to identify factors associated with inadequate fruit and vegetable consumption.

Results: In our study, 86% (95% CI: 82.07-89.93) of participants reported inadequate fruit and vegetable consumption. The food choice motives of "price" [aOR 2.99, 95% CI: 1.32-6.78], "health" [aOR 2.56, 95% CI: 1.08-6.24], and "sensory appeal" [aOR 2.20, 95% CI: 1.06-4.56] were found to be significantly associated with inadequate fruit and vegetable consumption per day (P < 0.05).

Conclusion: The high prevalence of inadequate fruit and vegetable consumption in this urban community necessitates targeted and comprehensive educational campaigns that highlight the health benefits and sensory appeal of fruits and vegetables, as well as the affordability of seasonal produce, to ensure adequate intake of these foods.

背景:现有文献没有说明高知市成年人不健康饮食(主要表现为水果和蔬菜摄入不足)与非传染性疾病危险因素相关的食物选择动机。我们的研究旨在测量该城市人口中水果和蔬菜摄入不足的普遍程度,并确定高危人群优先选择食物的动机:我们以社区为基础,通过群组抽样对 300 名成年人(平均年龄 46 岁,男性占 50%)进行了横断面研究。通过预先测试的结构化访谈表收集了有关社会人口变量、饮食和食物选择动机的信息。通过二元逻辑回归分析,确定了与水果和蔬菜摄入不足有关的因素:在我们的研究中,86%(95% CI:82.07-89.93)的参与者表示水果和蔬菜摄入不足。研究发现,"价格"[aOR 2.99,95% CI:1.32-6.78]、"健康"[aOR 2.56,95% CI:1.08-6.24]和 "感官吸引力"[aOR 2.20,95% CI:1.06-4.56]等食物选择动机与每天水果和蔬菜摄入量不足显著相关(P < 0.05):该城市社区水果和蔬菜摄入量不足的发生率很高,因此有必要开展有针对性的综合教育活动,强调水果和蔬菜对健康的益处和感官吸引力,以及季节性农产品的可负担性,以确保人们摄入足够的水果和蔬菜。
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引用次数: 0
Healthcare workers' perceptions and acceptance for COVID-19 vaccine for their children aged <18 years from the Region of Eastern Uttar Pradesh, India. 印度北方邦东部地区医护人员对其 18 岁以下儿童接种 COVID-19 疫苗的看法和接受程度。
IF 1.1 Q4 PRIMARY HEALTH CARE Pub Date : 2024-09-01 Epub Date: 2024-09-11 DOI: 10.4103/jfmpc.jfmpc_1727_23
Imran Ahmed Khan, Md Abu Bashar, Amresh Kumar Singh

Background: The coronavirus disease 2019 (COVID-19) vaccination program among adults in India is one of the highly successful vaccination drives globally, but the acceptance of the COVID-19 vaccine among parents for their children is largely unknown. As parents are primary decision-makers for their children, we aimed to assess parents' perceptions and acceptance for COVID-19 vaccination for children in India.

Aim: To assess parental perceptions and acceptance for COVID-19 vaccination for their children (aged <18 years).

Materials and methods: A cross-sectional anonymous web-based survey was designed and conducted from November 1 to December 15, 2022. All the healthcare workers of a tertiary care institute in eastern Uttar Pradesh, having a child aged <18 years, constituted the study population and were invited. They were recruited through snowball sampling and were sent the study questionnaire in Google form through email and WhatsApp. Bivariate analysis was performed to determine the predictors of child vaccination acceptance among the parents.

Results: A total of 388 healthcare worker parents (HCWPs) having a child <18 years of age completed the survey. The mean age of the parents was 40.28 ± 11.34 years. The majority (96.9%) of them had already received the recommended two doses of the COVID-19 vaccine. Around 91% of the parents agreed that COVID-19 vaccines are important for children's health, whereas 89% agreed that COVID-19 vaccines are effective. A total of 356 (91.7%) parents were willing to vaccinate their children with a COVID-19 vaccine, of which 91.3% intended to do so as soon as possible. The factors significantly associated with the stated willingness for child vaccination among the participants were younger age (P = 0.008), female gender (P = 0000), currently married status (P = 0.00001), urban residence (P = 0.01), lower monthly income (P = 0.03), absence of any chronic illness (P = 0.0003), history of COVID-19 in the child (P = 0.004), and the child being up-to-date with the routine childhood vaccines (P = 0.01).

Conclusion: The HCWPs from eastern Uttar Pradesh, India, have a positive attitude and low vaccine hesitancy toward COVID-19 vaccination for children, with around 92% currently willing to vaccinate their children with COVID vaccine. Further longitudinal studies are required to assess the trend of parental acceptance of COVID vaccine.

背景:印度在成人中开展的冠状病毒病 2019(COVID-19)疫苗接种计划是全球非常成功的疫苗接种活动之一,但父母对子女接种 COVID-19 疫苗的接受程度却不甚了解。由于父母是子女的主要决策者,我们旨在评估印度父母对儿童接种 COVID-19 疫苗的看法和接受程度:设计了一项横断面匿名网络调查,并于 2022 年 11 月 1 日至 12 月 15 日进行。调查对象为北方邦东部一家三级医疗机构的所有医护人员,他们的子女年龄均为 5 岁:共有 388 名医护人员父母(HCWPs)有一个孩子(P = 0.008)、性别为女性(P = 0000)、目前已婚(P = 0.00001)、居住在城市(P = 0.01)、月收入较低(P = 0.03)、没有任何慢性疾病(P = 0.0003)、孩子有 COVID-19 病史(P = 0.004)、孩子接种了常规儿童疫苗(P = 0.01):结论:印度北方邦东部的家庭主妇对儿童接种 COVID-19 疫苗持积极态度,疫苗接种犹豫率较低,目前约有 92% 的家庭主妇愿意为其子女接种 COVID 疫苗。需要进一步开展纵向研究,以评估家长接受 COVID 疫苗的趋势。
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引用次数: 0
Seroprevalent study of cytomegalovirus infection in the regions of Jharkhand. 恰尔肯德邦地区巨细胞病毒感染血清流行研究。
IF 1.1 Q4 PRIMARY HEALTH CARE Pub Date : 2024-09-01 Epub Date: 2024-09-11 DOI: 10.4103/jfmpc.jfmpc_259_24
Anita Sundi, Nilamber Roopa, Piyalee Gupta, Sana Irfan, Tarun Kumar Kar

Background: The Human Cytomegalovirus (HCMV) is a type of beta herpesvirus widespread in all human populations. It is estimated that up to 80-100% of adults worldwide and most infections are harmless and can cause severe health complications in infants, like hearing loss and developmental issues. Still, immunocompromised individuals can experience serious complications from the virus. Unfortunately, there is limited information on the prevalence of this virus in our country, and no studies have been reported on the rate of CMV transmission yet.

Objectives: This study aims to evaluate the levels of IgM antibodies against Cytomegalovirus (CMV) in East Singhbhum, West Singhbhum, and Seraikela Kharsawan using an ELISA test.

Methods: An indirect ELISA test was performed to detect anti-CMV IgM and the period of study was from January'2021 to June'2023.

Results: The examination tested 55 people for the TORCH profile of CMV parameters from regions of East Singhbhum, West Singhbhum, and Seraikela Kharsawan. Here, 17 people (30.09%) were IgM positive by ELISA.

Conclusions: The serological data confirms that CMV is not being monitored and recognized in the general population, which limits our study between CMV infection, disease, and clinically diagnosed outcomes. This understanding is crucial for the healthcare and policy sectors. Thus, we recommend implementing a surveillance and mindfulness program for at least one-fourth of the population in Jharkhand and continuing to explore and develop effective vaccines to control CMV infections.

背景:人类巨细胞病毒(HCMV)是一种广泛存在于所有人群中的β疱疹病毒。据估计,全球有高达 80-100% 的成年人感染了该病毒,而且大多数感染是无害的,但会对婴儿的健康造成严重的并发症,如听力损失和发育问题。不过,免疫力低下的人也会因病毒而出现严重的并发症。遗憾的是,关于这种病毒在我国流行情况的资料有限,也没有关于 CMV 传播率的研究报告:本研究旨在使用 ELISA 检测法评估东辛布姆、西辛布姆和 Seraikela Kharsawan 的巨细胞病毒(CMV)IgM 抗体水平:方法:采用间接 ELISA 试验检测抗巨细胞病毒 IgM,研究时间为 2021 年 1 月至 2023 年 6 月:检查对来自东辛格布姆(East Singhbhum)、西辛格布姆(West Singhbhum)和Seraikela Kharsawan地区的55人进行了CMV参数TORCH图谱检测。其中,17 人(30.09%)通过 ELISA 检测呈 IgM 阳性:血清学数据证实,CMV 在普通人群中未得到监测和识别,这限制了我们对 CMV 感染、疾病和临床诊断结果之间关系的研究。这种认识对医疗保健和政策部门至关重要。因此,我们建议对恰尔肯德邦至少四分之一的人口实施监测和认知计划,并继续探索和开发有效的疫苗来控制 CMV 感染。
{"title":"Seroprevalent study of cytomegalovirus infection in the regions of Jharkhand.","authors":"Anita Sundi, Nilamber Roopa, Piyalee Gupta, Sana Irfan, Tarun Kumar Kar","doi":"10.4103/jfmpc.jfmpc_259_24","DOIUrl":"10.4103/jfmpc.jfmpc_259_24","url":null,"abstract":"<p><strong>Background: </strong>The Human Cytomegalovirus (HCMV) is a type of beta herpesvirus widespread in all human populations. It is estimated that up to 80-100% of adults worldwide and most infections are harmless and can cause severe health complications in infants, like hearing loss and developmental issues. Still, immunocompromised individuals can experience serious complications from the virus. Unfortunately, there is limited information on the prevalence of this virus in our country, and no studies have been reported on the rate of CMV transmission yet.</p><p><strong>Objectives: </strong>This study aims to evaluate the levels of IgM antibodies against Cytomegalovirus (CMV) in East Singhbhum, West Singhbhum, and Seraikela Kharsawan using an ELISA test.</p><p><strong>Methods: </strong>An indirect ELISA test was performed to detect anti-CMV IgM and the period of study was from January'2021 to June'2023.</p><p><strong>Results: </strong>The examination tested 55 people for the TORCH profile of CMV parameters from regions of East Singhbhum, West Singhbhum, and Seraikela Kharsawan. Here, 17 people (30.09%) were IgM positive by ELISA.</p><p><strong>Conclusions: </strong>The serological data confirms that CMV is not being monitored and recognized in the general population, which limits our study between CMV infection, disease, and clinically diagnosed outcomes. This understanding is crucial for the healthcare and policy sectors. Thus, we recommend implementing a surveillance and mindfulness program for at least one-fourth of the population in Jharkhand and continuing to explore and develop effective vaccines to control CMV infections.</p>","PeriodicalId":15856,"journal":{"name":"Journal of Family Medicine and Primary Care","volume":"13 9","pages":"4066-4070"},"PeriodicalIF":1.1,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11504779/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142501822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Central diabetes insipidus: A rare primary manifestation of small-cell lung carcinoma. 中枢性糖尿病:小细胞肺癌的一种罕见原发表现。
IF 1.1 Q4 PRIMARY HEALTH CARE Pub Date : 2024-09-01 Epub Date: 2024-09-11 DOI: 10.4103/jfmpc.jfmpc_36_24
S Kavya, Avinash H Rajanna, Naval Kishore, Aditya Chandrashekar

Diabetes insipidus (DI) is a disorder of water hemostasis that is associated with polyuria-polydipsia syndrome. Central DI (CDI) primarily results from autoimmune destruction, traumatic injury, or anatomical damage caused by neoplasms. Craniopharyngioma, germinoma, and distant metastases are the main neoplastic causes, with pituitary adenomas rarely manifesting as CDI. Pituitary gland metastasis is rare, with the vast majority of cases being asymptomatic. We present a rare case of pituitary metastasis originating from small-cell carcinoma of the lung with CDI and skin swellings as the primary manifestation, without any evidence of the primary malignancy upon initial presentation. A 56-year-old chronic smoker with newly diagnosed type-2 diabetes mellitus presented with a history of polydipsia and polyuria along with soft tissue swellings in the axilla and the chest for the last 3 months. A water deprivation test and a desmopressin challenge test were performed, revealing the presence of CDI. In light of the CDI, a contrast-enhanced magnetic resonance imaging brain was performed, which displayed a loss of pituitary bright spot and four T2 isointense lesions with post-contrast enhancement in the left frontal, parietal, occipital, and right temporal lobes, suggestive of metastatic lesions. Fine needle aspiration cytology of the swelling revealed cytomorphological characteristics indicating the presence of malignancy, specifically favoring carcinoma. Contrast-enhanced computed tomography thorax revealed a right hilar lung mass infiltrating the surrounding structures with multiple regional and distant metastases. A lung biopsy confirmed the presence of small-cell lung carcinoma (SCLC). The final diagnosis was advanced SCLC with multiple distant metastases associated with CDI, and the patient is currently receiving palliative care and inhalational desmopressin. In conclusion, metastatic lesions and lung cancer must be considered early when patients present with polydipsia and polyuria symptoms.

糖尿病性尿崩症(DI)是一种与多尿多脂综合征相关的止水障碍。中枢性尿崩症(CDI)主要源于自身免疫性破坏、外伤或肿瘤造成的解剖学损伤。颅咽管瘤、生殖细胞瘤和远处转移是主要的肿瘤病因,垂体腺瘤很少表现为 CDI。垂体转移罕见,绝大多数病例无症状。我们报告了一例罕见的垂体转移瘤病例,该病源于肺小细胞癌,以CDI和皮肤肿胀为主要表现,最初发病时没有任何原发恶性肿瘤的证据。一名 56 岁的新诊断 2 型糖尿病患者长期吸烟,近 3 个月来出现多尿多饮症状,同时伴有腋窝和胸部软组织肿胀。患者接受了缺水试验和去氨加压素挑战试验,结果显示其患有 CDI。鉴于 CDI,该患者接受了对比增强脑磁共振成像检查,结果显示垂体亮点消失,左侧额叶、顶叶、枕叶和右侧颞叶出现四个 T2 等密度病灶,且对比后增强,提示为转移性病灶。肿物的细针穿刺细胞学检查显示,细胞形态学特征表明存在恶性肿瘤,尤其是癌。胸部对比增强计算机断层扫描显示,右侧肺门肿块浸润周围结构,并伴有多个区域和远处转移灶。肺部活检证实了小细胞肺癌(SCLC)的存在。最终诊断为晚期SCLC,伴有CDI的多发远处转移,患者目前正在接受姑息治疗和吸入去氨加压素。总之,当患者出现多尿和多尿症状时,必须及早考虑转移性病灶和肺癌。
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引用次数: 0
Feedback to national medical commission regarding aadhar-enabled biometric attendance system at medical colleges in India. 向印度国家医学委员会反馈有关印度医学院采用 Aadhar 生物识别考勤系统的信息。
IF 1.1 Q4 PRIMARY HEALTH CARE Pub Date : 2024-09-01 Epub Date: 2024-09-11 DOI: 10.4103/jfmpc.jfmpc_303_24
Harish Gupta

Teachers are the backbone of any country, the pillars upon which all aspirations and dreams converge, if we paraphrase 11th President of India, Dr A P J Abdul Kalam,. A teacher of a Medical college has immense potential to shape the foundation and basic wisdom/ technical skills of a young student and resident. So, teachers' absence makes the learners bereft of these gifts- making them vulnerable to construct poor reasoning and judging clinical scenarios inappropriately: deriving incorrect or false interpretation from a given case presentation. For this reason, when the National Medical Commission (NMC) comes up and pushes for an idea ensuring physical presence of workforce at their respective workplaces, everyone should welcome the move. Nevertheless, like every fixture the virtual solution has its unique challenges, requiring nuances for proper assessment, demands reasoned and detailed dissection of actual ground -level situation; hence, I want the regulatory body to tweak the attendance -system to make it suitable for diverse atmosphere, varying working -conditions and rapidly -changing environment. Such formulation should have two- way communication channels between man (and woman) power as well as their regulators. Only then fine -tuning may be expected to be achieved to derive the maximum benefit while reducing chances of error/ omission/ glitch/ incompleteness and fault.

教师是任何一个国家的脊梁,是汇聚所有愿望和梦想的支柱。医学院的教师在为年轻学生和住院医师打基础、培养基本智慧/技术技能方面潜力巨大。因此,教师的缺失使学生失去了这些天赋,使他们容易形成错误的推理,并对临床情景做出不恰当的判断:从给定的病例演示中得出错误或虚假的解释。因此,当国家医学委员会(NMC)提出并推动确保工作人员在各自工作场所实际工作的想法时,每个人都应该欢迎这一举措。然而,就像每个固定装置一样,虚拟解决方案也有其独特的挑战,需要细微差别以进行正确评估,需要对实际情况进行推理和详细分析;因此,我希望监管机构能够调整考勤制度,使其适合不同的氛围、不同的工作条件和快速变化的环境。在制定这种制度时,男(女)权力机构及其监管机构之间应建立双向沟通渠道。只有这样,才有望实现微调,以获得最大效益,同时减少错误/遗漏/故障/不完整和过失的机会。
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引用次数: 0
Routine ante-natal screening using maternal risk factors and biomarkers for preeclampsia in 11-13+6 weeks of gestation. 在妊娠 11-13+6 周时,利用母体风险因素和生物标志物对先兆子痫进行常规产前筛查。
IF 1.1 Q4 PRIMARY HEALTH CARE Pub Date : 2024-09-01 Epub Date: 2024-09-11 DOI: 10.4103/jfmpc.jfmpc_160_24
Anusuya Sarma, Subrat Panda, Ananya Das, Nalini Sharma, Donboklang Lynser, Kaushiki Singh

Background: Prediction of preeclampsia in first trimester can lead to early initiation of preventative measures, as well as timely therapeutic intervention, that will prevent the maternal and perinatal morbidity and mortality. This study, prediction of preeclampsia at 11-13+6 weeks of gestation, was conducted by using serum placental growth factor (PlGF), serum pregnancy associated plasma protein - A (PAPP-A), uterine artery Doppler indices, and mean arterial pressure (MAP), in low-risk pregnant women.

Methods: It is an observational longitudinal prospective study. Pregnant women with singleton pregnancies of gestational age 11-13+6 weeks were recruited. MAP, bilateral uterine artery Doppler indices, serum PAPP-A, and PlGF were measured. The follow-up of the patients was regularly done till termination of pregnancy and incidence of preeclampsia were noted. Qualitative variables were compared using Chi-square/Fisher exact test, and sensitivity and specificity of each test were analyzed.

Result: Among 139 women, 27 (19%) developed preeclampsia, out of which 10 had early preeclampsia and 17 developed late preeclampsia. By combining all the parameters, the sensitivity in detecting early preeclampsia was found to be 70% and for late preeclampsia cases, 64.7%. The sensitivity of all the parameters in predicting cases of preeclampsia in general is 66.7%, specificity is 74.1%, PPV is 38.3%, and NPV is 72%.

Conclusion: The maternal biomarkers serum PAPP-A, serum PlGF, uterine artery PI, MAP have sensitivity of 70% in detecting early preeclampsia cases and for late preeclampsia cases, 64.71%, in first trimester and it will help in early initiation of preventative measures as well as timely therapeutic intervention.

背景:在妊娠头三个月预测子痫前期可以及早采取预防措施,并及时进行治疗干预,从而避免孕产妇和围产期的发病率和死亡率。本研究通过使用低危孕妇的血清胎盘生长因子(PlGF)、血清妊娠相关血浆蛋白-A(PAPP-A)、子宫动脉多普勒指数和平均动脉压(MAP)来预测妊娠 11-13+6 周的子痫前期:这是一项观察性纵向前瞻研究。方法:这是一项观察性纵向前瞻性研究,招募孕龄为 11-13+6 周的单胎孕妇。测量血压、双侧子宫动脉多普勒指数、血清 PAPP-A 和 PlGF。定期对患者进行随访,直至终止妊娠,并记录子痫前期的发生率。采用Chi-square/Fisher精确检验比较定性变量,并分析每种检验的敏感性和特异性:在 139 名妇女中,有 27 人(19%)出现子痫前期,其中 10 人出现早期子痫前期,17 人出现晚期子痫前期。综合所有参数,发现检测早期子痫前期的灵敏度为 70%,检测晚期子痫前期的灵敏度为 64.7%。所有参数预测子痫前期病例的灵敏度为 66.7%,特异性为 74.1%,PPV 为 38.3%,NPV 为 72%:母体生物标志物血清 PAPP-A、血清 PlGF、子宫动脉 PI 和 MAP 在妊娠头三个月检测早期子痫前期病例的灵敏度为 70%,检测晚期子痫前期病例的灵敏度为 64.71%,这将有助于及早采取预防措施并及时进行治疗干预。
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引用次数: 0
Serum retinol binding protein 4 in individuals with essential hypertension and type 2 diabetes: A cross-sectional study. 本质性高血压和 2 型糖尿病患者的血清视黄醇结合蛋白 4:一项横断面研究
IF 1.1 Q4 PRIMARY HEALTH CARE Pub Date : 2024-09-01 Epub Date: 2024-09-11 DOI: 10.4103/jfmpc.jfmpc_57_24
Anand G Jadhao, Kapila B Gaikwad, Ravi R Yadav

Background: Cardiometabolic disorders, notably primary hypertension and type 2 diabetes, present substantial global health challenges. The intricate interplay between metabolic and cardiovascular pathways has prompted extensive research into molecular mechanisms linking these conditions. The adipokine Retinol Binding Protein 4 (RBP4), initially recognized for retinol transport, has emerged as a potential biomarker in the network of metabolic and cardiovascular dysfunction. Recent studies implicate RBP4 in insulin resistance and its complications, including hypertension. This study explores RBP4 dynamics in patients with primary hypertension and type 2 diabetes, aiming to contribute valuable insights into diagnostic and therapeutic advancements in managing these interconnected disorders.

Methods: This cross-sectional study, conducted over 2 years in a tertiary healthcare centre of North India, aimed to investigate the serum concentration of Retinol Binding Protein 4 (RBP4) in 119 participants diagnosed with primary hypertension and type 2 diabetes. Ethical guidelines were strictly followed, and comprehensive clinical assessments, including blood pressure measurements, were performed. RBP4 levels were quantified using an ELISA kit, alongside markers of insulin resistance. Statistical analyses, involving t-tests and correlation assessments, sought to unravel potential associations between RBP4, insulin resistance, and blood pressure parameters using SPSS 20.0.

Results: The study comprised 61 healthy control (HC) participants and 58 individuals diagnosed with both essential hypertension and type 2 diabetes (EH+T2D). EH+T2D participants were on average older (45.71 ± 9.29 years vs. 40.34 ± 9.47 years, P = 0.002). Dyslipidemia prevalence was markedly higher in EH+T2D (72.4% vs. 11.4%, P < 0.0001), accompanied by disrupted lipid profiles. Serum RBP4 concentration was significantly elevated in EH+T2D (49.17 ± 19.37 mg/L, P < 0.0001), suggesting its potential role in the shared pathophysiology of primary hypertension and type 2 diabetes. Pearson's correlation analysis revealed associations between RBP4 levels, metabolic, and cardiovascular parameters, underscoring its potential as a link between these conditions.

Conclusion: Elevated serum RBP4 levels suggest its potential as a novel biomarker in the shared pathophysiology of primary hypertension and type 2 diabetes. The correlation analysis highlights the intricate interplay between metabolic, lipid, and cardiovascular parameters, emphasizing the need for holistic interventions.

背景:心血管代谢疾病,尤其是原发性高血压和 2 型糖尿病,给全球健康带来了巨大挑战。新陈代谢和心血管疾病之间错综复杂的相互作用促使人们对这些疾病的分子机制进行广泛研究。脂肪因子视黄醇结合蛋白 4(RBP4)最初被认为用于视黄醇转运,现已成为代谢和心血管功能障碍网络中的潜在生物标志物。最近的研究表明,RBP4 与胰岛素抵抗及其并发症(包括高血压)有关。本研究探讨了原发性高血压和 2 型糖尿病患者体内 RBP4 的动态变化,旨在为管理这些相互关联疾病的诊断和治疗进展提供有价值的见解:这项横断面研究在印度北部的一家三级医疗保健中心进行,历时两年,旨在调查 119 名确诊为原发性高血压和 2 型糖尿病患者血清中视黄醇结合蛋白 4 (RBP4) 的浓度。该研究严格遵守伦理准则,并进行了包括血压测量在内的全面临床评估。使用酶联免疫吸附试剂盒对 RBP4 和胰岛素抵抗标记物的水平进行了量化。使用 SPSS 20.0 进行统计分析,包括 t 检验和相关性评估,试图揭示 RBP4、胰岛素抵抗和血压参数之间的潜在关联:研究对象包括 61 名健康对照组(HC)参与者和 58 名被诊断出患有原发性高血压和 2 型糖尿病(EH+T2D)的患者。EH+T2D参与者的平均年龄较大(45.71 ± 9.29 岁 vs. 40.34 ± 9.47 岁,P = 0.002)。血脂异常在 EH+T2D 中的发生率明显更高(72.4% 对 11.4%,P < 0.0001),同时伴有血脂谱紊乱。EH+T2D的血清RBP4浓度明显升高(49.17 ± 19.37 mg/L,P < 0.0001),这表明RBP4在原发性高血压和2型糖尿病的共同病理生理学中发挥着潜在作用。皮尔逊相关性分析表明,RBP4水平与代谢和心血管参数之间存在关联,强调了其在这些疾病之间的潜在联系:结论:血清 RBP4 水平升高表明,它有可能成为原发性高血压和 2 型糖尿病共同病理生理学中的新型生物标志物。相关性分析凸显了代谢、血脂和心血管参数之间错综复杂的相互作用,强调了整体干预的必要性。
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引用次数: 0
Integrating physiotherapy in rural primary health care: Early lessons on the value, feasibility, and emerging role of the physiotherapist from a community-oriented primary care (COPC) program in Rajasthan, India. 将物理治疗纳入农村初级医疗保健:从印度拉贾斯坦邦以社区为导向的初级医疗保健(COPC)项目中汲取物理治疗师的价值、可行性和新兴角色的早期经验。
IF 1.1 Q4 PRIMARY HEALTH CARE Pub Date : 2024-09-01 Epub Date: 2024-09-11 DOI: 10.4103/jfmpc.jfmpc_1540_23
Colis Anwari, Deekshita Yadav, Gargi Goel, B C Rao, Pavitra Mohan, Ramakrishna Prasad

Background: Physiotherapists are health professionals who enhance mobility and quality of life (QoL) through clinical reasoning and the application of evaluation and treatment strategies. Their role is crucial in promoting health, preventing injury, and maintaining function.

Aim: This paper aims to (1) share early experiences and learnings from integrating physiotherapy in rural primary health care, (2) discuss the scope and role of physiotherapists in the primary care team, (3) list the competencies of physiotherapists in rural primary care settings, and (4) advocate for a re-imagined role of physiotherapists as multi-skilled "primary care physiotherapists."

Setting and method: Using a selection of case stories from rural primary health care settings, the paper provides insights into the integration and impact of physiotherapy within these communities.

Results: The integration of physiotherapy in rural primary health care has demonstrated significant benefits in promoting comprehensive primary health care. The case stories highlight the expanded scope and essential competencies of physiotherapists as vital members of the primary care team.

Conclusion: This paper emphasizes the critical role physiotherapy plays in primary health care and calls for broader recognition and support for physiotherapists. It underscores the need for a re-imagined perspective of physiotherapists in rural settings, advocating for their role as multi-skilled primary care professionals.

背景:物理治疗师是通过临床推理以及评估和治疗策略的应用来提高活动能力和生活质量(QoL)的卫生专业人员。目的:本文旨在(1)分享将物理治疗融入农村初级卫生保健的早期经验和教训;(2)讨论物理治疗师在初级卫生保健团队中的范围和角色;(3)列举物理治疗师在农村初级卫生保健环境中的能力;以及(4)倡导将物理治疗师的角色重新定位为多技能的 "初级卫生保健物理治疗师":本文通过选取农村初级医疗机构中的案例,深入探讨了物理治疗在这些社区中的整合及其影响:结果:将物理治疗融入农村初级医疗保健,对促进全面的初级医疗保健具有显著的益处。案例故事突出了物理治疗师作为初级医疗团队重要成员的扩展范围和基本能力:本文强调了物理治疗在初级医疗保健中发挥的关键作用,并呼吁对物理治疗师给予更广泛的认可和支持。本文强调了在农村地区重新认识物理治疗师的必要性,倡导物理治疗师作为具备多种技能的初级保健专业人员发挥作用。
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引用次数: 0
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Journal of Family Medicine and Primary Care
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