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An inverted partially epithelialized connective tissue graft around dental implants: A report of three cases. 牙种植体周围倒置部分上皮化结缔组织移植物:附3例报告。
Q2 Dentistry Pub Date : 2025-09-01 Epub Date: 2025-12-17 DOI: 10.4103/jisp.jisp_364_24
Ioannis Tsourounakis, Carlo Sgarbanti

In clinical practice, it is common to encounter dental implants with insufficient keratinized mucosa width (KMW) and decreased peri-implant mucosa thickness (MT). Research indicates that such soft-tissue deficiencies can lead to unsatisfactory esthetic results and decreased bone stability over time. This case report presents a variation of standard free gingival graft and connective tissue graft (CTG) techniques, termed the inverted partially epithelialized CTG (IPE-CTG). Three patients (2 males and 1 female) experiencing insufficient attached gingiva and reduced peri-implant tissue volume were effectively treated with the IPE-CTG. This approach involves placing a partially epithelialized graft as an onlay graft on the recipient site, with the epithelialized surface oriented apically and the de-epithelialized surface directed coronally. This technique aims to address KMW and MT deficiencies in a single procedure. All cases treated with the IPE-CTG exhibited stable results over a 12-month period, with notable improvements in both KMW and MT.

在临床实践中,经常会遇到牙种植体角化粘膜宽度(KMW)不足和种植体周围粘膜厚度(MT)减少的情况。研究表明,随着时间的推移,这种软组织缺陷会导致不满意的审美结果和骨稳定性下降。本病例报告提出了一种标准游离牙龈移植和结缔组织移植(CTG)技术的变化,称为倒置部分上皮化CTG (IPE-CTG)。应用IPE-CTG有效治疗了3例(男2例,女1例)附着龈不足和种植周组织体积减小的患者。这种方法包括将部分上皮化的移植物作为贴壁移植物放置在受体部位,上皮化的表面朝向顶端,去上皮化的表面朝向冠状。该技术旨在解决单一程序中KMW和MT的缺陷。所有接受IPE-CTG治疗的病例在12个月期间均表现出稳定的结果,KMW和MT均有显着改善。
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引用次数: 0
Assessment of noncarious cervical lesions in areas of gingival recession specific to the minimally invasive restoration-guided creeping attachment technique: A cross-sectional study. 微创修复引导下匍匐附着技术对牙龈退行区非龋齿宫颈病变的评估:一项横断面研究。
Q2 Dentistry Pub Date : 2025-09-01 Epub Date: 2025-12-17 DOI: 10.4103/jisp.jisp_512_24
Rupasree Gundala, Sreenivas Nagarakanti

Background: A noncarious cervical lesion (NCCL) is defined as the loss of tooth structure in the cervical one-third of the tooth due to causes other than dental caries. Descriptive epidemiological studies on NCCLs are justified because of their high frequency and their potential consequences for the periodontium. The present study aimed to analyze the trend of NCCLs in teeth with gingival recession, determine the prevalence and associated risk factors for these combined lesions, and evaluate patient acceptance of various treatment modalities, with emphasis on the minimally invasive restoration-guided creeping attachment (RGCA) technique.

Materials and methods: A total of 150 patients were enrolled in the present study. A total of 1200 teeth were examined clinically using ×3.5 magnification loupes and a UNC-15 probe to evaluate the cementoenamel junction and step-like defects according to the Pini-Prato classification of gingival recession. All patients were interviewed regarding potential etiological factors using a specially designed questionnaire. The questionnaire also included attitudinal factors related to willingness for treatment in general and specifically for the RGCA technique.

Results: Among the 1200 teeth with exposed root surfaces, 543 exhibited Class A - defects, 442 Class A+, 149 Class B+, and 66 Class B- defects. The distribution of combined defects across tooth types was incisors 39%, premolars 32%, canines 22%, and molars 6%, with 92% located in the anterior esthetic zone.

Conclusions: Combined lesions were predominantly found in incisors, premolars, and canines located within the smile arc.

背景:非龋齿性宫颈病变(NCCL)被定义为由于龋齿以外的原因导致的三分之一牙齿颈部的牙齿结构丧失。描述性流行病学研究是合理的,因为它们的高频率和对牙周组织的潜在后果。本研究旨在分析伴有牙龈退缩的牙齿ncls的发展趋势,确定这些合并病变的患病率及相关危险因素,并评估患者对各种治疗方式的接受程度,重点研究微创修复引导匍匐附着(RGCA)技术。材料与方法:本研究共纳入150例患者。采用×3.5放大镜和UNC-15探针,根据牙龈退缩的Pini-Prato分类,对1200颗牙进行临床检查,评估牙髓-牙釉质连接处和阶梯状缺损。所有患者均采用特别设计的问卷调查潜在病因。问卷还包括与一般治疗意愿有关的态度因素,特别是RGCA技术。结果:1200颗牙根面外露,A级缺损543颗,A+级缺损442颗,B+级缺损149颗,B级缺损66颗。综合缺损在各牙型中的分布为门牙39%,前磨牙32%,犬齿22%,磨牙6%,其中92%位于前美观区。结论:合并病变主要发生在门牙、前磨牙和犬齿内。
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引用次数: 0
Root submergence in maxillary anterior region: An alternative for unpredictable augmentation. 上颌前牙根部埋没:一种不可预测的隆胸方法。
Q2 Dentistry Pub Date : 2025-09-01 Epub Date: 2025-12-17 DOI: 10.4103/jisp.jisp_367_23
Farhan Durrani, Aishwarya Pandey, Kajol Kumari Rajak, Dhanraj Meena, Mahendra Rawji Gawade

Alveolar ridge resorption following tooth extraction is a progressive and inevitable process, particularly critical in the maxillary anterior region where esthetics are paramount. Conventional approaches to restoring hard and soft tissue contours often yield unpredictable results, especially in recreating papillary form and ridge architecture. The root submergence technique (RST), which involves the intentional decoronation and submergence of nonrestorable teeth, aims to preserve the periodontal ligament and maintain surrounding tissue integrity. This case report presents two clinical scenarios in which submerged roots were retained beneath implant-supported fixed prostheses in the anterior maxilla. In both cases, careful case selection and precise execution of RST resulted in preservation of the interdental papilla, stable crestal bone levels, and harmonious soft-tissue profiles over a 1-year follow-up. These outcomes highlight the potential of RST as a biologically driven alternative to extensive ridge augmentation procedures, offering superior esthetic results in challenging anterior prosthetic rehabilitations.

拔牙后的牙槽嵴吸收是一个渐进的、不可避免的过程,在上颌前牙区尤其重要。传统的恢复硬组织和软组织轮廓的方法通常会产生不可预测的结果,特别是在重建乳头状结构和脊状结构时。牙根埋没技术(RST)是一种将不可修复的牙齿进行有意的修复和埋没的技术,其目的是保护牙周韧带和维持周围组织的完整性。本病例报告介绍了两种临床情况,其中上颌前牙种植体支持的固定假体下保留了淹没根。在这两个病例中,经过1年的随访,仔细的病例选择和精确的RST执行导致保留了牙间乳头,稳定的嵴骨水平和和谐的软组织轮廓。这些结果突出了RST作为广泛的脊隆手术的生物学驱动替代方案的潜力,在具有挑战性的前路假体康复中提供了优越的美学效果。
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引用次数: 0
Periodontology in the classroom: A scoping review of educational strategies and outcomes in dental education. 课堂上的牙周病:牙科教育策略和结果的范围审查。
Q2 Dentistry Pub Date : 2025-09-01 Epub Date: 2025-12-17 DOI: 10.4103/jisp.jisp_505_24
Fara Azwin Adam

Background and objectives: Periodontology is a crucial component of dental education, focusing on the supporting structures of teeth and the prevention, diagnosis, and treatment of periodontal diseases. This scoping review aims to explore various educational approaches and outcomes related to periodontology, highlighting their effectiveness and identifying areas for improvement.

Materials and methods: A comprehensive search of the PubMed, Education Resource Information Center, and Scopus databases was conducted using the search terms related to dental education, periodontology, and educational methods. Inclusion criteria included original dental education articles that described periodontology as the subject of interest. Twenty-two studies met the inclusion criteria and were included in this scoping review.

Results: The studies used a variety of educational methods to teach periodontology, including lecture-based teaching, problem-based learning, simulation-based education, hands-on training, flipped classrooms, and team-based learning. The results suggest that different educational methods have varying levels of effectiveness in achieving knowledge gain, clinical skills, and student satisfaction. Simulation-based education and hands-on training were found to be more effective in improving clinical skills than lecture-based teaching.

Conclusion: This scoping review highlights the importance of innovative educational strategies in periodontology, including active learning and blended learning. The findings suggest that a variety of educational methods can be effective in teaching periodontology and that the choice of method depends on the specific learning objectives and outcomes desired. The results of this review can inform the development of effective educational programs in periodontology and highlight the need for further research in this area.

背景和目的:牙周病学是牙科教育的重要组成部分,侧重于牙齿的支撑结构和牙周病的预防、诊断和治疗。本综述旨在探讨与牙周病相关的各种教育方法和结果,强调其有效性并确定需要改进的领域。材料和方法:对PubMed、教育资源信息中心和Scopus数据库进行综合检索,检索词涉及牙科教育、牙周病学和教育方法。纳入标准包括将牙周病描述为感兴趣主题的原始牙科教育文章。22项研究符合纳入标准,纳入本范围综述。结果:这些研究使用了多种教育方法来教授牙周病,包括基于讲座的教学、基于问题的学习、基于模拟的教育、实践培训、翻转课堂和基于团队的学习。结果表明,不同的教育方法在获得知识、临床技能和学生满意度方面具有不同程度的有效性。以模拟为基础的教育和实践培训在提高临床技能方面比以讲座为基础的教学更有效。结论:本综述强调了牙周病学创新教育策略的重要性,包括主动学习和混合学习。研究结果表明,多种教育方法可以有效地教授牙周病,方法的选择取决于具体的学习目标和期望的结果。本综述的结果可以为制定有效的牙周病教育计划提供信息,并强调该领域进一步研究的必要性。
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引用次数: 0
World AMR Awareness Week (WAAR) 2025: "Let us contribute our bit of share". 2025年世界抗菌素耐药性宣传周:“让我们贡献自己的一份力量”。
Q2 Dentistry Pub Date : 2025-09-01 Epub Date: 2025-12-17 DOI: 10.4103/jisp.jisp_536_25
Baljeet Singh
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引用次数: 0
Estimation of plasma afamin levels in patients with periodontitis and Type II diabetes mellitus: A clinico-biochemical study. 评估牙周炎和2型糖尿病患者血浆维生素A水平:一项临床生化研究。
Q2 Dentistry Pub Date : 2025-09-01 Epub Date: 2025-12-17 DOI: 10.4103/jisp.jisp_259_24
Rumaisa Rehman, K Asif, H Sindhura, Swapna Ediga

Introduction: Periodontitis is a chronic inflammatory disease, modified by host immune response, where the host-microbial interaction damages proteoglycan, hyaluronan, and collagen, leading to connective tissue breakdown and impaired wound healing due to increased oxidative stress (OS). Afamin (AFM) is a Vitamin E-binding protein that plays a role in antiapoptotic cellular processes related to OS and has been previously associated with the development of insulin resistance (IR). Type II diabetes mellitus (TIIDM) is a major risk factor for periodontitis. The aim of this study was to assess plasma AFM levels in subjects diagnosed with periodontitis, with and without TIIDM.

Materials and methods: Seventy-five participants were divided into 3 groups: Group I - 25 healthy controls, Group II - 25 systemically healthy individuals with periodontitis, and Group III - 25 individuals with periodontitis and TIIDM. All periodontal parameters, i.e. plaque index, gingival index, and probing pocket depth, were recorded. Glycemic control in Group III individuals was assessed by glycated hemoglobin (HbA1c) levels. Plasma AFM levels were analyzed using the enzyme-linked immunosorbent assay technique. P < 0.05 was considered to be statistically significant.

Results: Mean plasma AFM concentrations in Group I were 30.64 ± 5.88 ng/ml. A significant increase in mean AFM was seen in Group II and III, i.e. 50.76 ± 9.65 ng/ml and 86.44 ± 12.10 ng/ml, respectively. A correlation was seen between deep pockets and increased AFM concentration in both the test groups. It was also found that mean AFM concentrations increased with worsening of glycemic control, i.e. 80.25 ng/ml, 84.25 ng/ml, and 90.92 ng/ml in good, fair, and poor HbA1c control patients, respectively.

Conclusions: Plasma AFM is increased in patients with periodontitis. A higher concentration is seen in patients with periodontitis and TIIDM. OS being the reason for its increase, plasma AFM levels can be used as a marker to identify the incidence of TIIDM in individuals with periodontitis or other inflammatory conditions associated with increased OS.

牙周炎是一种慢性炎症性疾病,由宿主免疫反应修饰,其中宿主-微生物相互作用破坏蛋白聚糖、透明质酸和胶原蛋白,导致结缔组织破坏和氧化应激(OS)增加导致伤口愈合受损。Afamin (AFM)是一种维生素e结合蛋白,在与OS相关的抗凋亡细胞过程中发挥作用,并且先前与胰岛素抵抗(IR)的发展有关。2型糖尿病(TIIDM)是牙周炎的主要危险因素。本研究的目的是评估诊断为牙周炎的受试者的血浆AFM水平,无论是否伴有TIIDM。材料和方法:75名参与者分为3组:第一组- 25名健康对照,第二组- 25名全身健康的牙周炎患者,第三组- 25名牙周炎和TIIDM患者。记录所有牙周参数,即菌斑指数、牙龈指数和探诊袋深度。III组患者的血糖控制通过糖化血红蛋白(HbA1c)水平进行评估。采用酶联免疫吸附测定技术分析血浆AFM水平。P < 0.05为差异有统计学意义。结果:ⅰ组AFM平均血药浓度为30.64±5.88 ng/ml。第2组和第3组AFM均显著升高,分别为50.76±9.65 ng/ml和86.44±12.10 ng/ml。在两个测试组中,深口袋与AFM浓度增加之间存在相关性。研究还发现,AFM的平均浓度随着血糖控制的恶化而升高,在HbA1c控制良好、一般和较差的患者中分别为80.25 ng/ml、84.25 ng/ml和90.92 ng/ml。结论:牙周炎患者血浆AFM增高。在牙周炎和慢性牙周炎患者中可见较高的浓度。作为其增加的原因,血浆AFM水平可作为识别与OS增加相关的牙周炎或其他炎症的个体中TIIDM发生率的标志物。
{"title":"Estimation of plasma afamin levels in patients with periodontitis and Type II diabetes mellitus: A clinico-biochemical study.","authors":"Rumaisa Rehman, K Asif, H Sindhura, Swapna Ediga","doi":"10.4103/jisp.jisp_259_24","DOIUrl":"10.4103/jisp.jisp_259_24","url":null,"abstract":"<p><strong>Introduction: </strong>Periodontitis is a chronic inflammatory disease, modified by host immune response, where the host-microbial interaction damages proteoglycan, hyaluronan, and collagen, leading to connective tissue breakdown and impaired wound healing due to increased oxidative stress (OS). Afamin (AFM) is a Vitamin E-binding protein that plays a role in antiapoptotic cellular processes related to OS and has been previously associated with the development of insulin resistance (IR). Type II diabetes mellitus (TIIDM) is a major risk factor for periodontitis. The aim of this study was to assess plasma AFM levels in subjects diagnosed with periodontitis, with and without TIIDM.</p><p><strong>Materials and methods: </strong>Seventy-five participants were divided into 3 groups: Group I - 25 healthy controls, Group II - 25 systemically healthy individuals with periodontitis, and Group III - 25 individuals with periodontitis and TIIDM. All periodontal parameters, i.e. plaque index, gingival index, and probing pocket depth, were recorded. Glycemic control in Group III individuals was assessed by glycated hemoglobin (HbA1c) levels. Plasma AFM levels were analyzed using the enzyme-linked immunosorbent assay technique. <i>P</i> < 0.05 was considered to be statistically significant.</p><p><strong>Results: </strong>Mean plasma AFM concentrations in Group I were 30.64 ± 5.88 ng/ml. A significant increase in mean AFM was seen in Group II and III, i.e. 50.76 ± 9.65 ng/ml and 86.44 ± 12.10 ng/ml, respectively. A correlation was seen between deep pockets and increased AFM concentration in both the test groups. It was also found that mean AFM concentrations increased with worsening of glycemic control, i.e. 80.25 ng/ml, 84.25 ng/ml, and 90.92 ng/ml in good, fair, and poor HbA1c control patients, respectively.</p><p><strong>Conclusions: </strong>Plasma AFM is increased in patients with periodontitis. A higher concentration is seen in patients with periodontitis and TIIDM. OS being the reason for its increase, plasma AFM levels can be used as a marker to identify the incidence of TIIDM in individuals with periodontitis or other inflammatory conditions associated with increased OS.</p>","PeriodicalId":15890,"journal":{"name":"Journal of Indian Society of Periodontology","volume":"29 5","pages":"501-505"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12736694/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145834103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparative assessment of regenerative potential of 0.8% hyaluronic acid gel combined with deproteinized bovine bone mineral in the management of furcation defects: A randomized controlled clinical study. 0.8%透明质酸凝胶联合去蛋白牛骨矿物质治疗功能缺损再生潜力的比较研究:一项随机对照临床研究。
Q2 Dentistry Pub Date : 2025-09-01 Epub Date: 2025-12-17 DOI: 10.4103/jisp.jisp_333_24
S Elanchezhiyan, A Nirmal Priya, P K Sasi Kumar, S Santhosh, Nivethitha Maruthamuthu, Sundarrajan Murali

Background: Periodontal regeneration is particularly challenging in complex anatomical areas such as furcation defects. This study clinically and radiographically evaluated the outcomes of treating mandibular molar furcation defects in Stage II and III, Grade A and B periodontitis patients using either 0.8% hyaluronic acid (HA) gel combined with deproteinized bovine bone mineral (DBBM) or DBBM alone.

Materials and methods: A total of 20 furcation defects were treated. Group 1 received open flap debridement with DBBM alone, whereas Group 2 received DBBM mixed with 0.8% HA gel. An amniotic membrane (AM) was placed as the guided tissue regeneration (GTR) membrane for both the groups. Clinical parameters including plaque index (PlI), gingival index (GI), horizontal probing pocket depth (H-PPD), vertical probing pocket depth (V-PPD), and relative attachment level (RAL), along with radiographic parameters such as defect depth, bone fill (BF), and percentage bone fill (BF%), were recorded at baseline, 3 months, and 6 months.

Results: At 6 months, significant improvements were observed in both the groups, with Group 2 demonstrating superior outcomes. The PlI and GI showed mean reductions of 0.47 ± 0.06 and 0.56 ± 0.08, respectively. Group 2 exhibited greater reductions in H-PPD (3 ± 0.59 mm), V-PPD (4.7 ± 1.72 mm), and RAL (4.6 ± 1.02 mm). Radiographically, Group 2 showed a mean BF of 1.26 ± 0.35 mm at 3 months and 3.01 ± 0.41 mm at 6 months, with corresponding BF% values of 38.40 ± 6.04% and 83.80 ± 6.12%.

Conclusion: The combination of 0.8% HA gel with DBBM and AM demonstrated superior clinical and radiographic improvements in furcation defect management compared to DBBM alone.

背景:牙周再生是特别具有挑战性的复杂解剖区域,如分叉缺陷。本研究评估了0.8%透明质酸(HA)凝胶联合去蛋白牛骨矿物质(DBBM)或单独使用DBBM治疗II期和III期、A级和B级牙周炎患者下颌磨牙功能缺损的临床和影像学结果。材料与方法:共处理了20个官能化缺陷。组1采用DBBM单独开瓣清创,组2采用DBBM混合0.8% HA凝胶。两组均放置羊膜(AM)作为引导组织再生(GTR)膜。临床参数包括牙菌斑指数(PlI)、牙龈指数(GI)、水平探测袋深度(H-PPD)、垂直探测袋深度(V-PPD)和相对附着水平(RAL),以及影像学参数如缺损深度、骨填充(BF)和骨填充百分比(BF%),分别在基线、3个月和6个月进行记录。结果:6个月时,两组患者均有显著改善,其中第2组疗效更佳。PlI和GI分别平均降低0.47±0.06和0.56±0.08。2组H-PPD(3±0.59 mm)、V-PPD(4.7±1.72 mm)、RAL(4.6±1.02 mm)明显降低。2组3个月平均BF为1.26±0.35 mm, 6个月平均BF为3.01±0.41 mm,相应BF%分别为38.40±6.04%和83.80±6.12%。结论:与单用DBBM相比,0.8% HA凝胶联合DBBM和AM在功能缺损管理方面表现出更优越的临床和影像学改善。
{"title":"Comparative assessment of regenerative potential of 0.8% hyaluronic acid gel combined with deproteinized bovine bone mineral in the management of furcation defects: A randomized controlled clinical study.","authors":"S Elanchezhiyan, A Nirmal Priya, P K Sasi Kumar, S Santhosh, Nivethitha Maruthamuthu, Sundarrajan Murali","doi":"10.4103/jisp.jisp_333_24","DOIUrl":"10.4103/jisp.jisp_333_24","url":null,"abstract":"<p><strong>Background: </strong>Periodontal regeneration is particularly challenging in complex anatomical areas such as furcation defects. This study clinically and radiographically evaluated the outcomes of treating mandibular molar furcation defects in Stage II and III, Grade A and B periodontitis patients using either 0.8% hyaluronic acid (HA) gel combined with deproteinized bovine bone mineral (DBBM) or DBBM alone.</p><p><strong>Materials and methods: </strong>A total of 20 furcation defects were treated. Group 1 received open flap debridement with DBBM alone, whereas Group 2 received DBBM mixed with 0.8% HA gel. An amniotic membrane (AM) was placed as the guided tissue regeneration (GTR) membrane for both the groups. Clinical parameters including plaque index (PlI), gingival index (GI), horizontal probing pocket depth (H-PPD), vertical probing pocket depth (V-PPD), and relative attachment level (RAL), along with radiographic parameters such as defect depth, bone fill (BF), and percentage bone fill (BF%), were recorded at baseline, 3 months, and 6 months.</p><p><strong>Results: </strong>At 6 months, significant improvements were observed in both the groups, with Group 2 demonstrating superior outcomes. The PlI and GI showed mean reductions of 0.47 ± 0.06 and 0.56 ± 0.08, respectively. Group 2 exhibited greater reductions in H-PPD (3 ± 0.59 mm), V-PPD (4.7 ± 1.72 mm), and RAL (4.6 ± 1.02 mm). Radiographically, Group 2 showed a mean BF of 1.26 ± 0.35 mm at 3 months and 3.01 ± 0.41 mm at 6 months, with corresponding BF% values of 38.40 ± 6.04% and 83.80 ± 6.12%.</p><p><strong>Conclusion: </strong>The combination of 0.8% HA gel with DBBM and AM demonstrated superior clinical and radiographic improvements in furcation defect management compared to DBBM alone.</p>","PeriodicalId":15890,"journal":{"name":"Journal of Indian Society of Periodontology","volume":"29 5","pages":"506-513"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12736670/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145834136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Indian Society of Periodontology Scientific Events. 印度牙周病科学事件学会。
Q2 Dentistry Pub Date : 2025-09-01 Epub Date: 2025-12-17 DOI: 10.4103/jisp.jisp_558_25
{"title":"Indian Society of Periodontology Scientific Events.","authors":"","doi":"10.4103/jisp.jisp_558_25","DOIUrl":"https://doi.org/10.4103/jisp.jisp_558_25","url":null,"abstract":"","PeriodicalId":15890,"journal":{"name":"Journal of Indian Society of Periodontology","volume":"29 5","pages":"572"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12736735/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145834222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Porous Ti6Al4V with controlled oxidation toward improved osseointegration of dental implant. 多孔Ti6Al4V控制氧化对牙种植体骨整合的改善。
Q2 Dentistry Pub Date : 2025-09-01 Epub Date: 2025-12-17 DOI: 10.4103/jisp.jisp_148_25
Rajashree Ganguly, Samir Das, Sundeep Venkata Sussela, Pravin Vasudeo Vaidya, Nantu Dogra, Tamal Kanti Pal, Madhumita Majumdar, Santanu Dhara

Background: Titanium (Ti) implants are known to be bioinert, stress shielding, and poor osseointegration, due to modulus discrepancy with native bone. This research aims to design a porous Ti6Al4V implant with controllable oxidation to mimic the natural bone properties for better osseointegration.

Materials and methods: Porous Ti6Al4V foams were manufactured by coagulant-assisted metal foaming with egg white protein and citric acid as stabilizing matrix. The detailed characterization was conducted using X-ray diffraction, Fourier transform infrared spectroscopy, scanning electron microscopy, nanoindentation, and microcomputed tomography (micro-CT) to characterize microstructural, porosity, and mechanical properties. MTT assay and dual staining were used to study in vitro cytocompatibility using the human amniotic mesenchymal stem cells. In vivo biocompatibility and bone regeneration were evaluated through the rabbit femoral defect model at 4 and 12 weeks, using histology and micro-CT for bone ingrowth quantification.

Results: The fabricated porous Ti6Al4V implants had 71%-75% porosity, facilitating nutrient transport and cellular ingrowth. Compressive modulus (284 MPa), measured via mechanical testing, was comparable to that of trabecular bone. In vitro studies demonstrated good cell viability and proliferation. In vivo, robust new bone formation was observed (~52% increase in bone volume), with over 90% tissue integration compared to control.

Conclusions: Controlled oxidation of porous Ti6Al4V foam could provide a potential way to overcome the current limitations of dental implants. The improved biomechanical compatibility and osseointegration support its potential for clinical application in implantology.

背景:钛(Ti)种植体由于与天然骨的模量差异而具有生物惰性、应力屏蔽和较差的骨整合性。本研究旨在设计一种具有可控氧化的多孔Ti6Al4V种植体,以模拟天然骨的特性,从而实现更好的骨整合。材料与方法:以蛋清蛋白和柠檬酸为稳定基质,采用混凝辅助金属发泡法制备多孔Ti6Al4V泡沫。利用x射线衍射、傅里叶变换红外光谱、扫描电子显微镜、纳米压痕和微计算机断层扫描(micro-CT)对其进行了详细的表征,以表征其微观结构、孔隙率和力学性能。采用MTT法和双染色法研究人羊膜间充质干细胞的体外细胞相容性。通过兔股骨缺损模型在4周和12周进行体内生物相容性和骨再生评估,利用组织学和显微ct对骨长入进行量化。结果:制备的多孔Ti6Al4V种植体孔隙率为71% ~ 75%,有利于营养物质的运输和细胞的生长。压缩模量(284 MPa),通过力学测试测量,与小梁骨相当。体外研究显示出良好的细胞活力和增殖能力。在体内,观察到强健的新骨形成(骨体积增加~52%),与对照组相比,组织整合超过90%。结论:控制多孔Ti6Al4V泡沫的氧化为克服目前种植体的局限性提供了一种潜在的方法。改善的生物力学相容性和骨整合支持其在种植临床应用的潜力。
{"title":"Porous Ti6Al4V with controlled oxidation toward improved osseointegration of dental implant.","authors":"Rajashree Ganguly, Samir Das, Sundeep Venkata Sussela, Pravin Vasudeo Vaidya, Nantu Dogra, Tamal Kanti Pal, Madhumita Majumdar, Santanu Dhara","doi":"10.4103/jisp.jisp_148_25","DOIUrl":"10.4103/jisp.jisp_148_25","url":null,"abstract":"<p><strong>Background: </strong>Titanium (Ti) implants are known to be bioinert, stress shielding, and poor osseointegration, due to modulus discrepancy with native bone. This research aims to design a porous Ti6Al4V implant with controllable oxidation to mimic the natural bone properties for better osseointegration.</p><p><strong>Materials and methods: </strong>Porous Ti6Al4V foams were manufactured by coagulant-assisted metal foaming with egg white protein and citric acid as stabilizing matrix. The detailed characterization was conducted using X-ray diffraction, Fourier transform infrared spectroscopy, scanning electron microscopy, nanoindentation, and microcomputed tomography (micro-CT) to characterize microstructural, porosity, and mechanical properties. MTT assay and dual staining were used to study <i>in vitro</i> cytocompatibility using the human amniotic mesenchymal stem cells. <i>In vivo</i> biocompatibility and bone regeneration were evaluated through the rabbit femoral defect model at 4 and 12 weeks, using histology and micro-CT for bone ingrowth quantification.</p><p><strong>Results: </strong>The fabricated porous Ti6Al4V implants had 71%-75% porosity, facilitating nutrient transport and cellular ingrowth. Compressive modulus (284 MPa), measured via mechanical testing, was comparable to that of trabecular bone. <i>In vitro</i> studies demonstrated good cell viability and proliferation. <i>In vivo</i>, robust new bone formation was observed (~52% increase in bone volume), with over 90% tissue integration compared to control.</p><p><strong>Conclusions: </strong>Controlled oxidation of porous Ti6Al4V foam could provide a potential way to overcome the current limitations of dental implants. The improved biomechanical compatibility and osseointegration support its potential for clinical application in implantology.</p>","PeriodicalId":15890,"journal":{"name":"Journal of Indian Society of Periodontology","volume":"29 5","pages":"537-547"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12736681/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145834277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Frozen advanced platelet-rich fibrin as an adjunct to the modified tunnel technique for root coverage: A pilot randomised clinical trial. 冷冻晚期富血小板纤维蛋白作为改良隧道技术根根覆盖的辅助手段:一项先导随机临床试验。
Q2 Dentistry Pub Date : 2025-09-01 Epub Date: 2025-12-17 DOI: 10.4103/jisp.jisp_419_24
Sruthima N V S Gottumukkala, Murali Krishna, Gautami S Penmetsa, K S V Ramesh, P Mohan Kumar, Anusha Boddeda, Bhavya Manchala

Background: Platelet-rich fibrin (PRF) is a widely used second-generation blood concentrate in periodontal regeneration. It has a few disadvantages, such as the fragile nature of the membrane, difficulty in suturing, and unpredictability of outcomes. The present study aims to evaluate the clinical outcomes, healing, and postoperative morbidity following the use of frozen advanced PRF (-20°C for 24 h) with modified coronally advanced tunnel (MCAT) technique in the treatment of multiple adjacent recession defects (MARDs).

Materials and methods: This is a prospective, split-mouth, randomized controlled clinical trial including 42 teeth with bilateral MARD in 10 participants. Sites were randomized to frozen (Fz-PRF) and fresh advanced PRF (A-PRF) groups and treated with Fz-PRF using MCAT and A-PRF using MCAT, respectively. Root coverage parameters (recession depth [RD], recession width [RW], complete root coverage, percentage root coverage [%RC], mechanical characteristics [needle passage ease, surgical handling of the membrane, and membrane fraying], postoperative healing [Wachtel's Healing Index], and patient-reported outcomes [discomfort and esthetic satisfaction]) were assessed.

Results: Mean %RC (P = 0.025), RW (0.044), mechanical characteristics (P = 0.000), and esthetic satisfaction (P = 0.015) were significantly better in the Fz-PRF group. No significant variation was observed in patient discomfort and postoperative healing.

Conclusions: Fz-PRF showed better root coverage, mechanical properties, and esthetic satisfaction than A-PRF; as a result, it might be an effective alternative to conventional methods of treating gingival recessions.

背景:富血小板纤维蛋白(PRF)是一种广泛应用于牙周再生的第二代血浓缩物。它有一些缺点,如膜的易碎性,缝合困难,以及结果的不可预测性。本研究旨在评估冷冻晚期PRF(-20°C保存24小时)与改良冠状进展隧道(MCAT)技术治疗多相邻退缩缺损(mard)的临床结果、愈合和术后发病率。材料和方法:这是一项前瞻性,裂口,随机对照临床试验,包括10名参与者42颗双侧MARD牙齿。试验点随机分为冷冻(Fz-PRF)组和新鲜晚期PRF (A-PRF)组,分别用MCAT治疗Fz-PRF和MCAT治疗A-PRF。评估根覆盖参数(消退深度[RD]、消退宽度[RW]、完全根覆盖、根覆盖百分比[%RC]、力学特征[针通过的便便性、手术对膜的处理和膜磨损]、术后愈合[Wachtel愈合指数]和患者报告的结果[不适和美学满意度])。结果:Fz-PRF组的平均%RC (P = 0.025)、RW(0.044)、力学特性(P = 0.000)和审美满意度(P = 0.015)均显著优于Fz-PRF组。在患者不适和术后愈合方面没有观察到明显的变化。结论:与A-PRF相比,Fz-PRF具有更好的根覆盖度、力学性能和审美满意度;因此,它可能是治疗牙龈衰退的传统方法的有效替代方法。
{"title":"Frozen advanced platelet-rich fibrin as an adjunct to the modified tunnel technique for root coverage: A pilot randomised clinical trial.","authors":"Sruthima N V S Gottumukkala, Murali Krishna, Gautami S Penmetsa, K S V Ramesh, P Mohan Kumar, Anusha Boddeda, Bhavya Manchala","doi":"10.4103/jisp.jisp_419_24","DOIUrl":"10.4103/jisp.jisp_419_24","url":null,"abstract":"<p><strong>Background: </strong>Platelet-rich fibrin (PRF) is a widely used second-generation blood concentrate in periodontal regeneration. It has a few disadvantages, such as the fragile nature of the membrane, difficulty in suturing, and unpredictability of outcomes. The present study aims to evaluate the clinical outcomes, healing, and postoperative morbidity following the use of frozen advanced PRF (-20°C for 24 h) with modified coronally advanced tunnel (MCAT) technique in the treatment of multiple adjacent recession defects (MARDs).</p><p><strong>Materials and methods: </strong>This is a prospective, split-mouth, randomized controlled clinical trial including 42 teeth with bilateral MARD in 10 participants. Sites were randomized to frozen (Fz-PRF) and fresh advanced PRF (A-PRF) groups and treated with Fz-PRF using MCAT and A-PRF using MCAT, respectively. Root coverage parameters (recession depth [RD], recession width [RW], complete root coverage, percentage root coverage [%RC], mechanical characteristics [needle passage ease, surgical handling of the membrane, and membrane fraying], postoperative healing [Wachtel's Healing Index], and patient-reported outcomes [discomfort and esthetic satisfaction]) were assessed.</p><p><strong>Results: </strong>Mean %RC (<i>P</i> = 0.025), RW (0.044), mechanical characteristics (<i>P</i> = 0.000), and esthetic satisfaction (<i>P</i> = 0.015) were significantly better in the Fz-PRF group. No significant variation was observed in patient discomfort and postoperative healing.</p><p><strong>Conclusions: </strong>Fz-PRF showed better root coverage, mechanical properties, and esthetic satisfaction than A-PRF; as a result, it might be an effective alternative to conventional methods of treating gingival recessions.</p>","PeriodicalId":15890,"journal":{"name":"Journal of Indian Society of Periodontology","volume":"29 5","pages":"514-521"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12736668/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145834284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Journal of Indian Society of Periodontology
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