Journal of Indian Society of Periodontology最新文献

Background: Minimally invasive periodontal surgery (MIPS) is an emerging surgical approach that has demonstrated improved clinical outcomes in the management of interproximal intraosseous periodontal defects. Despite its potential, only a limited number of research groups have contributed to the development and refinement of MIPS techniques, which may hinder their broader clinical adoption.

Objective: To examine publication trends and characterize the current state of research on MIPS through bibliometric indicators.

Materials and methods: A bibliometric analysis was conducted on Scopus-indexed documents published between 1996 and July 2023. Eligible records included original articles, reviews, and clinical trials that referenced MIPS techniques in their titles or abstracts. No categories of citable literature were excluded. Data extraction and analysis were performed using SciVal^® and VOSviewer^®.

Results: A total of 145 documents were identified. The most prolific contributors were P. Cortellini, S. Harrel, and L. Trombelli. Nearly 90% of publications on MIPS appeared in Q1 or Q2 journals. The simplified papilla preservation flap and the minimally invasive surgical technique were the most frequently reported approaches. Overall, annual publication growth in the field of MIPS reached 8.33%. Research output was primarily concentrated in Europe, particularly Italy, with limited contributions from other regions. Self-citation rates were high (23.3%).

Conclusion: Research on MIPS is expanding rapidly. Future efforts should prioritize multicenter collaborations, standardized methodology, and the development of international clinical guidelines to strengthen the evidence base and facilitate broader clinical implementation.

Background: With advances in diagnostic aids, the risk of periodontal disease can be identified and quantified by objective measures such as biomarkers. This research aims to assess the role of human leucine-rich alpha-2 glycoprotein (LRG) levels among healthy individuals and those suffering from periodontitis.

Materials and methods: An interventional clinicobiochemical study was performed on 50 individuals, who were systemically healthy and between 30 and 60 years. They were randomly allocated into two groups. Group I involved periodontally healthy and Group II involved Stage 1 Grade A periodontitis patients. Group II individuals were recalled after 6 weeks (Group X). Clinical outcomes such as probing pocket depth (PPD), clinical attachment levels (CAL), gingival index (GI) as well as plaque index (PI) were assessed. LRG levels from the gingival crevicular fluid were assessed and compared. Statistical analysis was performed with a paired t-test and post hoc Tukey's test to assess differences at 95% confidence intervals (P < 0.05).

Results: Statistically significant differences in clinical outcomes were observed between Group I, Group II, and Group X by evaluating PI, GI, and LRG levels. Similarly, a notable difference was observed between Group II and Group X in clinical outcomes such as PPD and CAL.

Conclusion: LRG can be used as a biomarker and shows a significant potential to be utilized as a future diagnostic tool for the detection of the severity of periodontal disease.

Odontogenic lesions are distinctive pathologies characterized by a wide age range of occurrence, notable radiographic features, and diverse histological patterns. Diagnostic complexity increases when central lesions appear at peripheral locations such as the gingiva. The calcifying odontogenic cyst (COC) is one such lesion, described under various terminologies depending on its histological and radiological features. This report describes a rare case of COC in an elderly female patient presenting with a swelling in the maxillary anterior region that was initially diagnosed as a peripheral ossifying fibroma. It underscores the clinical and histopathological findings and emphasizes the importance of recognizing the diverse gingival manifestations of odontogenic lesions to prevent diagnostic errors, recurrence, and inappropriate treatment outcomes.

Background: Although routine diagnostic procedures are simple, affordable, and largely noninvasive, they have less value in early predilection of disease and indicate previous destruction. As a result, a novel diagnostic test is required to accurately assess the ongoing activity of the disease, predict sites vulnerable to failure, and assess the effectiveness of periodontal interventions. Literature indicates that mannose-binding lectin (MBL) binds to pathogenic microorganisms and promotes their phagocytosis; hence, this study was conducted to determine if it can serve as a good biomarker for periodontal disease.

Aim and objective: The objective of our study was to assess the potential of MBL as a biomarker to detect periodontal disease.

Materials and methods: There were 50 participants whose clinical parameters, such as plaque index, gingival index, pocket probing depth, and clinical attachment loss, were recorded. For healthy participants, the sample was collected prescaling, and in the Stage I grade A periodontitis group, the sample was collected before scaling and 1 month postscaling. The blood samples were centrifuged to obtain serum and stored at -20°C. The samples were later analyzed using enzyme-linked immunosorbent assay.

Results: The difference was statistically insignificant for serum levels of MBL among periodontally healthy and Stage I grade A patients. Furthermore, the change was statistically insignificant in MBL levels after periodontal therapy in Stage I Grade A patients.

Conclusion: To gain further insights and confirm the promising role of MBL as a biomarker for periodontitis, future multicentred research trials are required.

Background: Platelet concentrates play an important role in gingival recession (GR) treatments. Hence, the existing study aimed to evaluate two different coronally advanced flap designs with advanced platelet-rich fibrin (A-PRF) in the treatment of human GR.

Materials and methods: This randomized clinical trial treated a total of 40 recession sites (20 per group). Trapezoidal and triangular flap designs were performed with A-PRF as biomaterial for GR. The clinical parameters such as probing depth, clinical attachment level, recession depth, recession width, width of keratinized tissue (WKT), and gingival thickness (GT), were recorded at baseline, 3, and 6 months.

Results: During intragroup comparison postoperatively, all the parameters showed a statistically significant difference. While intergroup comparison showed no significant difference, GT and WKT were increased at 3 and 6 months. At 3 months, percentage of mean root coverage (MRC%) obtained in Group 1 was 95.83% and in Group 2 was 97.3%. While at 6 months, MRC% for Groups 1 and 2 was 88.03% and 82.16%, respectively.

Conclusion: Both the flap techniques helped in improvement of clinical parameters for RC. A-PRF that was utilized in both groups helped in rapid healing without any adverse events. Even though the trapezoidal flap design showed keloid formation (KF), it was superior to the triangular flap design in terms of root coverage, as evidenced by higher GT and WKT and improved MRC%. The triangular flap design had the benefit of prevention of KF and improved the esthetic outcomes.

Background: Periodontal osseous defects, which are the sequelae of periodontitis, are often treated with open flap debridement and bone replacement grafts (BRG). Although various grafts are available for clinical use, none of them fulfill the ideal properties of the BRG, which underscores the need for newer regenerative materials. One such material, which is highly investigated, is the flavonoid. Flavonoids are phytochemical compounds that possess anti inflammatory, antioxidant, osteogenic, osteoprotective, and anti tumorogenic properties. Chrysin, a flavonoid obtained from the passion flower, honey, and mushrooms, has anti inflammatory properties, osteogenic potential, and accelerates wound healing. Thus, this study aims to analyze bone regeneration in a critical size defect treated with chrysin incorporated modified chitosan scaffold in a rat model.

Materials and methods: In this study, 18 male Wistar rats were enrolled, and they were allocated into three groups: Group I (defect only), Group II (defect treated with chitosan scaffolds), and Group III (defect treated with chrysin incorporated chitosan scaffolds). The outcomes were analyzed with radiographic and histologic parameters.

Results: On comparison between the groups, there was a statistically significant increase in the loose connective tissue in the chrysin group (Group III) (P = 0.032) in the 4^th week. The radiological parameters for bone regeneration (P = 0.91), histological woven bone formation (P = 0.15), and mineralization were not statistically significant, but the results were more predictable in the chrysin group when compared to the other two groups.

Conclusions: Thus, the present study reported that the chrysin molecule incorporated into the scaffold enhanced early wound healing and woven bone apposition. There was no statistically significant difference between the chrysin incorporated scaffold and the chitosan only scaffold, but the results showed a positive response in the chrysin incorporated group (Group III) when compared to the other 2 group.

Background: Furcation defects in periodontitis present treatment challenges due to complex anatomy. While guided tissue regeneration aids regeneration, periosteal isolation limits osteoblast contribution. The marginal periosteal membrane (MPM) serves as a biological barrier, potentially enhancing regeneration. Hence, the study aims to evaluate the application of a vascularized MPM in the treatment of mandibular Grade II furcation defects with and without bone graft in terms of defect depth reduction.

Materials and methods: A total of 60 patients, 30-50 years of age group having Stage III periodontitis with Grade II buccal furcation defect in a mandibular molar with vertical probing pocket depth (PPD) ≥5 mm at mid-furcation area were chosen. Control group (n = 30) was treated with MPM, and the test group (n = 30) with MPM with bone graft. Follow-up was done at the 3^rd and 12^th months following surgery for clinical parameters, i.e., mean plaque index (PI), modified sulcular bleeding index (mSBI), Visual Analog Scale score, healing index score, mean PPD, and relative clinical attachment level (RCAL) and 12 months for radiographic parameters such as horizontal defect depth and vertical defect depth with intraoral periapical radiograph and cone-beam computed tomography (CBCT), following which the statistical analysis was performed.

Results: Both groups improved significantly in PI, mSBI, PPD, and RCAL (P < 0.05). The test group showed better RCAL at 3 months (9.37 ± 1.10 mm vs 10.87 ± 0.68 mm) and 12 months (6.73 ± 1.40 mm vs. 8.77 ± 1.10 mm) (P < 0.05) while CBCT results revealed greater defect depth reduction (horizontal: 1.41 ± 0.25 mm vs. 1.55 ± 0.14 mm and vertical: 1.47 ± 0.23 mm vs. 1.62 ± 0.15 mm) (P < 0.05). No differences in wound healing score (P > 0.7) or pain perception (P > 0.68) were seen.

Conclusion: The study demonstrates that MPM significantly improves clinical and radiographic outcomes in Grade II furcation defects. MPM showed superior results when combined with bone graft, with greater RCAL gain and enhanced defect depth reduction. Hence, MPM with bone graft offers a more predictable regenerative approach for mandibular molar furcation defects.