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Short-term effects of air pollutants on hospitalization for childhood respiratory diseases in Suzhou City: a time-stratified case-crossover study. 苏州市空气污染物对儿童呼吸道疾病住院治疗的短期影响:一项时间分层病例交叉研究
IF 2.4 3区 医学 Q3 ENVIRONMENTAL SCIENCES Pub Date : 2024-12-04 DOI: 10.1186/s41043-024-00683-4
Ruoqi Zhang, Jiawei Chen, Mengru Wang, Zhengrong Chen, Hongpeng Sun

Background: Short-term exposure to air pollution has been demonstrated in previous studies to correlate with respiratory disease (RD) in children. Due to regional heterogeneity, our objective was to explore the correlation between short-term exposure to ambient air pollution and hospital admissions for respiratory ailments in children in Suzhou City from January 1, 2017, to December 31, 2022, alongside assessing the influence of the COVID-19 pandemic on this relationship.

Methods: We collected data on air pollutant levels and hospital admissions for childhood respiratory disease (RD) in Suzhou, China, from 2017 to 2022. We utilized a time-stratified case-crossover design along with a conditional logistic regression model to assess the short-term impacts of air pollutants on RD in children through stratified analysis and sensitivity analysis.

Results: A total of 13,408 children with respiratory diseases were included in the study. The findings revealed significant associations between hospitalization for respiratory diseases in children and exposure to PM2.5, PM10, SO2, NO2, and CO. The maximum effect values (95%CI, best lag days) for each 10 µg/m3 increase in the concentrations of PM2.5, PM10, SO2, and NO2 were as follows: 1.017 (1.003-1.031, lag0-2), 1.015 (1.004-1.026, lag0-2), 1.117 (1.001-1.247, lag0-1), and 1.036 (1.009-1.064, lag0-7). Additionally, the maximum effect value (95%CI, best lag days) for each 1 mg/m3 increase in CO concentration was found to be 1.267 1.017-1.579, lag0-7). Stratified analysis indicated that sex, season of admission, and stage of admission did not modify these correlations significantly; however, differential effects on various age groups and sexes were primarily observed among school-age and older children as well as boys.

Conclusions: The short-term exposure to PM2.5, PM10, SO2, NO2, and CO in Suzhou, China, exhibited a positive correlation with RD hospitalization. Prior to the COVID-19 pandemic, the adverse impacts of air pollutants on hospitalizations for childhood respiratory disease were mitigated compared to the period following the pandemic. Local governments should continue promoting decisions and measures for air pollution prevention and control to reduce further pollutant concentration, which is crucial for public health in reducing the burden of childhood respiratory diseases.

背景:以前的研究已经证明,短期暴露于空气污染与儿童呼吸道疾病(RD)有关。由于区域异质性,我们的目标是探讨2017年1月1日至2022年12月31日期间苏州市儿童短期暴露于环境空气污染与呼吸道疾病住院率之间的相关性,同时评估COVID-19大流行对这种关系的影响。方法:我们收集了2017年至2022年中国苏州地区空气污染物水平和儿童呼吸道疾病(RD)住院率的数据。我们采用时间分层病例交叉设计和条件逻辑回归模型,通过分层分析和敏感性分析来评估空气污染物对儿童RD的短期影响。结果:共纳入13408例呼吸系统疾病患儿。结果显示,儿童呼吸系统疾病住院与PM2.5、PM10、SO2、NO2和CO暴露之间存在显著相关性。PM2.5、PM10、SO2和NO2浓度每增加10µg/m3,最大效应值(95%CI,最佳滞后天数)分别为1.017 (1.003-1.031,lag0-2)、1.015 (1.004-1.026,lag0-2)、1.117 (1.001-1.247,lag0-1)和1.036 (1.009-1.064,lag0-7)。CO浓度每增加1 mg/m3,最大效应值(95%CI,最佳滞后天数)为1.267 (1.017 ~ 1.579,lag0 ~ 7)。分层分析表明,性别、入院季节和入院阶段对这些相关性没有显著影响;然而,对不同年龄组和性别的不同影响主要是在学龄和年龄较大的儿童以及男孩中观察到的。结论:中国苏州地区PM2.5、PM10、SO2、NO2和CO的短期暴露与RD住院呈正相关。在COVID-19大流行之前,与大流行之后的时期相比,空气污染物对儿童呼吸道疾病住院治疗的不利影响有所减轻。地方政府应继续推动大气污染防治决策和措施,进一步降低污染物浓度,这对减轻儿童呼吸道疾病负担的公共卫生至关重要。
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引用次数: 0
Retraction Note To: Nutrition self-efficacy assessment: designing and psychometric evaluation in a community-dwelling elderly population. 撤回注:营养自我效能评估:社区居住老年人的设计和心理测量评估。
IF 2.4 3区 医学 Q3 ENVIRONMENTAL SCIENCES Pub Date : 2024-12-04 DOI: 10.1186/s41043-024-00705-1
Abbas Shamsalinia, Reza Ghadimi, Razieh Torabi Chafjiri, Faezeh Norouzinejad, Ali Pourhabib, Fatemeh Ghaffari
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引用次数: 0
Serum vitamin D concentration and anthropometric indicators of adiposity in adults without or with low dose statin users: a cross-sectional study. 无或低剂量他汀类药物使用者的成人血清维生素D浓度和肥胖的人体测量指标:一项横断面研究。
IF 2.4 3区 医学 Q3 ENVIRONMENTAL SCIENCES Pub Date : 2024-12-02 DOI: 10.1186/s41043-024-00668-3
Haleh Ashraf, Nastaran Maghbouli, Maryam Abolhasani, Nadia Zandi, Mehran Nematizadeh, Negar Omidi, Gholamreza Davoodi, Mohammad Ali Boroumand, Jemal Haidar Ali

Background: This study sought to determine the accuracy of several anthropometric parameters in association with serum Vit. D concentrations and to compare the novel indices with the conventional ones.

Methods: A total of 947 individuals referred to the cardiology clinic who have not used statin or take low-dose statin were evaluated through a cross-sectional study. Data on demographic information, anthropometric indices, and biochemical measurements were gathered using a checklist. Both the multivariable regression modeling and the area under the receiver-operating characteristic (ROC) were employed for the analysis.

Results: Considering novel indices, BRI (Body Roundness Index) showed the most powerful correlation with serum Vit. D levels among both genders. Among conventional ancient indices, WC (Waist Circumference) had the strongest association in both men and women groups. Based on the confounding factors-adjusted model, the highest odds ratio (OR) for the presence of Vit. D deficiency belonged to WHtR (Waist to Height Ratio) in women (OR, 0.347 (0.171-0.704), P = 0.003). None of the indices predicted Vit. D deficiency significantly among men. A Vit. D concentration of 4.55 ng/ml was found as a cutoff based on the metabolic syndrome status.

Conclusion: The most powerful association with serum Vit. D levels were detected for BRI in both genders among newly developed indices. In addition, WHtR predicted Vit. D deficiency independent of confounding factors among women.

背景:本研究旨在确定与血清Vit相关的几个人体测量参数的准确性。并将新指标与常规指标进行比较。方法:通过横断面研究对947例未使用他汀类药物或服用低剂量他汀类药物的心脏病学门诊患者进行评估。使用核对表收集人口统计信息、人体测量指数和生化测量数据。采用多变量回归模型和受试者工作特征下面积(ROC)进行分析。结果:考虑到新的指标,身体圆度指数BRI与血清Vit的相关性最强。男性和女性的D水平。在传统的古代指标中,WC(腰围)在男女群体中相关性最强。根据混杂因素调整模型,Vit存在的最高优势比(OR)。女性D缺乏属于腰高比(WHtR) (OR, 0.347 (0.171 ~ 0.704), P = 0.003)。这些指标都没有预测到Vit。维生素D缺乏症在男性中尤为明显。维特。D浓度为4.55 ng/ml作为代谢综合征的临界值。结论:与血清Vit相关性最强。在新开发的指数中,检测了男女BRI的D水平。此外,WHtR预测了Vit。女性的D缺乏与混杂因素无关。
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引用次数: 0
Edible mushrooms as an alternative to animal proteins for having a more sustainable diet: a review. 食用蘑菇作为动物蛋白的替代品,具有更可持续的饮食:综述。
IF 2.4 3区 医学 Q3 ENVIRONMENTAL SCIENCES Pub Date : 2024-11-30 DOI: 10.1186/s41043-024-00701-5
Kimia Haji Ali Pashaei, Kiyavash Irankhah, Zahra Namkhah, Seyyed Reza Sobhani

Background: High protein sources especially animal protein is being used widely in people's diet. Ensuring a healthy and sustainable diet should be a global priority. Compared to diets rich in animal products, plant-based diets are more sustainable because they have less environmental impact. Aim of this article is to review mushroom's sustainability.

Main body: Using meat analogues like mushrooms seems to be a good option because their taste and texture are alike meat and they are sustainable healthy foods as they are good environmental choice due to their less water and land footprint but they are not a cost-benefit food.

Conclusion: Mushroom is a good nutritional and environmental meat substitute as it has less water and land footprint but not as a cost-benefit meat alternative. Therefore, the governments should make policies to use mushroom as an economical meat alternative and a source of protein for all consumers.

背景:高蛋白来源尤其是动物蛋白在人们的饮食中得到了广泛的应用。确保健康和可持续的饮食应成为全球优先事项。与富含动物产品的饮食相比,植物性饮食更具可持续性,因为它们对环境的影响较小。本文的目的是对蘑菇的可持续性进行综述。正文:使用像蘑菇这样的肉类类似物似乎是一个不错的选择,因为它们的味道和质地与肉类相似,它们是可持续的健康食品,因为它们的水和土地足迹更少,是很好的环保选择,但它们不是一种成本效益高的食物。结论:食用菌是一种营养和环境良好的肉类替代品,其水足迹和土地足迹较少,但不具有成本效益。因此,政府应该制定政策,将蘑菇作为一种经济的肉类替代品和所有消费者的蛋白质来源。
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引用次数: 0
The effects of Baduanjin exercise on the psychological condition and heart rate variability of sports-disadvantaged college students: A randomised trial. 八段锦运动对体育弱势大学生心理状况和心率变异性的影响:一项随机试验。
IF 2.4 3区 医学 Q3 ENVIRONMENTAL SCIENCES Pub Date : 2024-11-30 DOI: 10.1186/s41043-024-00691-4
Zhiping Wang, Zhaoxiang Zhang, Yingqing Wu

Objective: To investigate the effects of a 16-week Baduanjin exercise programme on the psychological status and heart rate variability (HRV) of college students in a sports-disadvantaged group, offering a theoretical basis for the potential of Baduanjin exercise to improve mental health.

Trial design: This prospective study enrolled 93 college students from Wuyi University, exempt from the National Standards for Students' Physical Health due to illness or disability. The participants were divided into a control group (n = 47) and an experimental group (n = 46). Over 16 weeks, the experimental group engaged in the Baduanjin exercise, whereas the control group did not participate in regular physical training.

Methods: We assessed the Symptom Checklist-90-Revised (SCL-90-R, the primary outcome) scores and HRV (time domain and frequency domain indices, the secondary outcomes) of all participants both before and after the 16-week programme.

Results: (1) Post-16 weeks of Baduanjin exercise, a statistically significant difference was observed in the SCL-90-R scores between the control and experimental groups (P < 0.01, P < 0.05). Notably, the scores for interpersonal sensitivity, depression, anxiety, psychoticism, and other factors (predominantly relating to sleep and diet) were significantly lower in the experimental group (t = 4.234, 2.616, 3.450, 2.226, 3.980, P < 0.01, P < 0.05). (2) Following the exercise regimen, the experimental group showed a substantial decrease in heart rate, low-frequency (LF) power, and the LF/high-frequency ratio (LF/HF ratio), and a significant increase in HF compared with the control group (t = 2.358, 4.528, - 2.595, P < 0.05 P < 0.01).

Conclusion: Sixteen weeks of Baduanjin exercise may substantially enhance HRV, potentially aiding in balancing sympathetic-vagal nerve activity and thus contributing to the regulation of mental health.

目的:探讨为期16周的八段锦运动对体育弱势群体大学生心理状态和心率变异性的影响,为八段锦运动改善心理健康的潜力提供理论依据。试验设计:本前瞻性研究纳入武夷大学93名因疾病或残疾而不符合《学生体质健康国家标准》的大学生。参与者被分为对照组(n = 47)和实验组(n = 46)。在16周的时间里,实验组进行八段锦运动,而对照组不参加常规的体育训练。方法:我们在16周计划前后对所有参与者的症状检查表-90-修订版(SCL-90-R,主要结局)评分和HRV(时域和频域指数,次要结局)进行评估。结果:(1)八段锦运动16周后,对照组与实验组的SCL-90-R评分差异有统计学意义(P)结论:16周八段锦运动可显著提高HRV,可能有助于平衡交感-迷走神经活动,从而对心理健康有调节作用。
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引用次数: 0
Trends and hotspots in research on osteoporosis and nutrition from 2004 to 2024: a bibliometric analysis. 2004 - 2024年骨质疏松与营养研究趋势与热点:文献计量分析
IF 2.4 3区 医学 Q3 ENVIRONMENTAL SCIENCES Pub Date : 2024-11-30 DOI: 10.1186/s41043-024-00690-5
Min Li, Binyang Yu, Haiyan Yang, Haiyan He, Ning Li, Aili Lv, Xiaoling Zhou, Rui Gao

Background: The intricate association between nutrition and osteoporosis has garnered increasing attention, and approximately 3000 articles have been published in the past 20 years. However, there are currently very few comprehensive reviews on the development of this field. It is very necessary to retrospectively analyze the related articles and summarize the research hotspots, depth, and directions.

Objectives: This study aimed to quantitatively analyze, visually review and comment on the articles published in the field of osteoporosis and nutrition based on the bibliometric methods, providing new insights for future research.

Methods: The related articles published from 2004 to 2024 were retrieved from the Web of Science Core Collection (WOSCC). CiteSpace 6.1R2 software was used to conduct collaborative network analysis of annual publication volume, author patterns, country/region contributions, institutional affiliations, journal publications, highly cited literature, and keyword clustering.

Results: A total of 2138 articles were assessed, revealing a consistent upward trend in published works in this domain, with the majority originating from the United States (564 papers). Seoul National University was identified as the most prolific institution (56 papers). Geng Bin was the most prolific author. Research hotspots included bone density, postmenopausal women, vitamin D, hip fractures, etc. Research subjects included physical activity, sarcopenia, calcium intake, machine learning, etc. Recent research trends indicate that cross-sectional study was more and the quality of life, muscle, and zinc are receiving attention in studies.

Conclusions: Future research should continue to explore better methods for measuring bone density, investigating indicators for predicting fracture risk, exploring the relationship between various nutrients and substances with osteoporosis at a deeper level, and bolstering management strategies for male osteoporosis. Researchers should conduct longitudinal or interventional studies, and further improving the overall quality of life of patients with osteoporosis.

背景:营养与骨质疏松症之间错综复杂的关系越来越受到人们的关注,在过去的20年里,大约有3000篇文章发表。然而,目前对这一领域的发展进行全面的综述很少。对相关文献进行回顾性分析,总结研究热点、深度和方向是非常有必要的。目的:利用文献计量学方法对骨质疏松与营养领域发表的文献进行定量分析、直观回顾和评价,为今后的研究提供新的见解。方法:检索Web of Science Core Collection (WOSCC) 2004 ~ 2024年发表的相关文章。采用CiteSpace 6.1R2软件对年出版量、作者模式、国家/地区贡献、机构隶属、期刊发表、高被引文献、关键词聚类等进行协同网络分析。结果:共评估了2138篇文章,显示该领域的已发表作品呈持续上升趋势,其中大部分来自美国(564篇)。首尔大学是发表论文最多的大学(56篇)。耿斌是最多产的作家。研究热点包括骨密度、绝经后妇女、维生素D、髋部骨折等。研究对象包括体力活动、肌肉减少症、钙摄入、机器学习等。近年来的研究趋势表明,横断面研究越来越多,生活质量、肌肉和锌的研究越来越受到关注。结论:未来的研究应继续探索更好的骨密度测量方法,研究预测骨折风险的指标,在更深层次上探索各种营养物质与骨质疏松症的关系,支持男性骨质疏松症的管理策略。研究者应开展纵向或介入性研究,进一步提高骨质疏松患者的整体生活质量。
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引用次数: 0
An epidemiological investigation of the prevalence of digestive diseases in the older prisoner population in Taiwan. 台湾老年囚犯消化系统疾病流行病学调查。
IF 2.4 3区 医学 Q3 ENVIRONMENTAL SCIENCES Pub Date : 2024-11-30 DOI: 10.1186/s41043-024-00693-2
Zhu Liduzi Jiesisibieke, Ping Tao, Yen-Chun Wang, Ching-Wen Chien, Tao-Hsin Tung

Objective: The prison population has been increasing globally, and prisoner health is an important issue of global health. However, it has not received sufficient attention, especially in developing countries and regions. Among all the prisoners, the health status of older prisoners requires special attention due to their declining health and energy. This study aims to assess the prevalence of digestive diseases among older prisoners in Taiwan.

Methods: Data on older prisoners from the National Health Insurance Research Database from January 1 to December 31, 2013, were used in this study. Digestive diseases were assessed in 2,215 older prisoners using the International Classification of Diseases, 9th revision Clinical Modification (ICD-9-CM). We identified the most common digestive diseases and explored any sex-specific differences in their prevalence.

Results: The estimated prevalence of digestive system diseases among the prisoners was 51.56%. Older women prisoners had a higher prevalence (62.68%) compared to men prisoners in general (50.80%). Diseases with a prevalence > 10% include esophageal, gastric, and duodenal diseases; diseases of the oral cavity, salivary glands, and jaws; and other intestinal and peritoneal diseases. Women prisoners showed a significantly higher prevalence of diseases of the oral cavity, salivary glands, jaws, esophagus, stomach, duodenum, non-infectious enteritis, and colitis.

Conclusion: Our findings indicate that a considerable number of older prisoners in Taiwan experienced digestive diseases, which may be attributable to general deterioration of physical function and poor resistance. Early detection and treatment are crucial for these conditions, and it is important to maintain human rights and justice in prison systems.

目的:全球监狱人口不断增加,囚犯健康是全球卫生的一个重要问题。然而,它没有得到足够的重视,特别是在发展中国家和地区。在所有囚犯中,老年囚犯的健康状况需要特别关注,因为他们的健康和精力都在下降。本研究旨在评估台湾老年囚犯消化系统疾病的患病率。方法:使用2013年1月1日至12月31日国家健康保险研究数据库中的老年囚犯数据进行研究。使用《国际疾病分类,第九版临床修改》(ICD-9-CM)对2,215名老年囚犯的消化系统疾病进行了评估。我们确定了最常见的消化系统疾病,并探讨了其患病率的性别差异。结果:服刑人员消化系统疾病患病率为51.56%。老年女性囚犯的患病率(62.68%)高于一般男性囚犯(50.80%)。患病率为10%的疾病包括食道、胃和十二指肠疾病;口腔、唾液腺和颌骨疾病;以及其他肠道和腹膜疾病。女性囚犯口腔、唾液腺、颌骨、食道、胃、十二指肠、非传染性肠炎和结肠炎的患病率明显较高。结论:我们的研究结果显示,台湾相当多的老年囚犯患有消化系统疾病,这可能是由于身体机能普遍恶化和抵抗力差。早期发现和治疗对这些疾病至关重要,在监狱系统中维护人权和正义也很重要。
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引用次数: 0
Incidence of type 2 diabetes mellitus in persons living with HIV initiated on dolutegravir-based antiretroviral regimen in Ghana: an observational longitudinal study. 2型糖尿病的发病率在艾滋病毒感染者开始在加纳多替格雷韦为基础的抗逆转录病毒治疗方案:一项观察性纵向研究。
IF 2.4 3区 医学 Q3 ENVIRONMENTAL SCIENCES Pub Date : 2024-11-29 DOI: 10.1186/s41043-024-00695-0
Margaret Lartey, Ernest Kenu, Vincent Ganu, Stephen Ayisi Addo, Kofi Agyabeng, Delia Bandoh, Marijanatu Abdulai, Prince Tsekpetse, Kwasi Torpey

Background: Few studies have reported hyperglycemia and diabetic ketoacidosis in patients on dolutegravir (DTG) treatment. This study determined the effect of DTG on fasting blood glucose levels in a cohort of persons living with HIV (PLHIV) in Ghana and initiating DTG regimens.

Methods: A two-year observational longitudinal cohort study conducted from 12th October 2020 to 31st December 2022. Fasting blood glucose was measured at baseline, 12, 24, 36 and 72 weeks for patients after a 12 h overnight fast. The Kaplan-Meier estimator was used to estimate the risk of developing type 2 diabetes mellitus (T2DM). Cox proportional hazard model was used in estimating hazard ratios.

Results: A total of 1334 non-diabetic patients were enrolled with 78% (1039) females and 83% (1104) were antiretroviral therapy experienced. The incidence proportion and rate of T2DM at 72 weeks were 11.8% (95%CI: 10.2-13.7) and 98.1 cases per 1000 PY (95%CI: 83.9-114.6) respectively. The median time to development of T2DM was 24 weeks post DTG initiation. Male sex (aHR 2.9 [95%CI: 1.9-4.3]), abnormal waist-hip ratio (1.67 [95% CI: 1.15-2.43]) and abnormal total serum cholesterol (aHR 1.6 [95%CI: 1.1-2.3]) were found to be significant determinants of T2DM.

Conclusion: Incidence of T2DM is high among non-diabetic PLHIV within 72 weeks of initiating DTG based therapy with males having a higher risk. Longitudinal changes in waist-hip ratio and serum cholesterol among patients initiated on DTG needs to be monitored regularly.

背景:很少有研究报道多替格拉韦(DTG)治疗患者出现高血糖和糖尿病酮症酸中毒。本研究确定了DTG对加纳HIV感染者(PLHIV)的空腹血糖水平的影响,并开始了DTG方案。方法:一项为期两年的观察性纵向队列研究,于2020年10月12日至2022年12月31日进行。禁食12小时后,分别在基线、12周、24周、36周和72周测量空腹血糖。Kaplan-Meier估计用于估计发生2型糖尿病(T2DM)的风险。采用Cox比例风险模型估计风险比。结果:共纳入1334例非糖尿病患者,其中78%(1039)为女性,83%(1104)为接受过抗逆转录病毒治疗的患者。72周T2DM的发病率和发生率分别为11.8% (95%CI: 10.2 ~ 13.7)和98.1例/ 1000 PY (95%CI: 83.9 ~ 114.6)。T2DM发展的中位时间为DTG开始后24周。男性(aHR为2.9 [95%CI: 1.9-4.3])、腰臀比异常(1.67 [95%CI: 1.15-2.43])和血清总胆固醇异常(aHR为1.6 [95%CI: 1.1-2.3])是T2DM的重要决定因素。结论:在开始DTG治疗的72周内,非糖尿病性PLHIV患者的T2DM发病率较高,其中男性风险更高。开始DTG治疗的患者腰臀比和血清胆固醇的纵向变化需要定期监测。
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引用次数: 0
Prevalence of inadequate HIV knowledge and its associated factors among the Malaysia general population: findings from the National Health and Morbidity Survey (NHMS) 2020. 马来西亚普通人群中艾滋病毒知识不足的普遍程度及其相关因素:2020年全国健康和发病率调查(NHMS)的调查结果。
IF 2.4 3区 医学 Q3 ENVIRONMENTAL SCIENCES Pub Date : 2024-11-29 DOI: 10.1186/s41043-024-00689-y
Muhammad Azri Adam Adnan, Norhafizah Sahril, Mohamad Aznuddin Abd Razak, Norliza Shamsuddin, Mohd Hazrin Hasim Hashim, Mohd Hatta Abdul Mutalip

Background: Inadequate knowledge of human immunodeficiency virus (HIV) is underscored as a key factor contributing to the HIV epidemic. Nonetheless, current data on HIV knowledge in Malaysia are still scarce. Therefore, this study aimed to assess the prevalence of inadequate HIV knowledge and its associated factors among the general Malaysian population.

Method: The study utilized data from the National Health and Morbidity Survey (NHMS) 2020, a nationwide cross-sectional survey employing a two-stage stratified random sampling technique to ensure national representativeness. HIV knowledge was assessed using the UNGASS indicators questionnaire, which comprises five questions on HIV prevention and transmission. The data were collected using the computer assisted telephone interviewing (CATI) method. Respondents who did not correctly answer all five questions were considered to have inadequate knowledge about HIV. Descriptive analysis and complex sample logistic regression were performed using SPSS version 28.0.

Results: The survey identified 5,561 eligible respondents, leading to the participation of 3,187 individuals in the second phase of the study, which resulted in a response rate of 57.3%. Our study revealed an overall prevalence of inadequate HIV knowledge at 77.4%, with adolescents aged 13-19 exhibiting the highest prevalence at 86.1%. Multiple logistic regression analysis indicated that respondents with no formal education (aOR 4.34, 95% CI: 0.65, 29.08) were over four times more likely to lack HIV knowledge. Additionally, respondents with only secondary education had an increased risk of 1.79 times. Individuals residing in rural areas were significantly more likely to have inadequate HIV-related knowledge. Furthermore, respondents who worked as unpaid workers, homemakers, or caregivers (aOR 1.71, 95% CI: 1.05, 2.82) showed a higher likelihood of lacking HIV knowledge.

Conclusion: Three out of four individuals in the general Malaysian population were found to lack sufficient knowledge about HIV. This underscores the need for targeted interventions in HIV education, particularly in rural areas and among populations with lower educational attainment. Additionally, digital platforms and youth-focused campaigns could be especially effective for reaching adolescents. Policymakers must prioritize inclusive, accessible HIV prevention strategies to address these gaps and reduce transmission rates.

背景:对人类免疫缺陷病毒(HIV)认识不足是导致HIV流行的一个关键因素。尽管如此,目前马来西亚关于艾滋病毒知识的数据仍然很少。因此,本研究旨在评估马来西亚普通人群中艾滋病毒知识不足的流行程度及其相关因素。方法:本研究使用的数据来自2020年国家健康和发病率调查(NHMS),这是一项全国性的横断面调查,采用两阶段分层随机抽样技术,以确保全国代表性。对艾滋病毒知识的评估采用特别联大指标问卷,其中包括关于艾滋病毒预防和传播的五个问题。资料采用计算机辅助电话访谈法(CATI)收集。没有正确回答所有五个问题的受访者被认为对艾滋病毒的了解不足。采用SPSS 28.0版本进行描述性分析和复样本logistic回归。结果:本次调查确定了5561名符合条件的受访者,导致3187人参与了第二阶段的研究,回复率为57.3%。我们的研究显示艾滋病毒知识不足的总体患病率为77.4%,其中13-19岁的青少年患病率最高,为86.1%。多元logistic回归分析显示,未接受过正规教育的受访者(aOR为4.34,95% CI为0.65,29.08)缺乏艾滋病知识的可能性高出四倍以上。此外,仅受过中等教育的受访者的风险增加了1.79倍。居住在农村地区的个人更有可能缺乏与艾滋病毒有关的知识。此外,从事无薪工人、家庭主妇或护理人员工作的受访者(aOR 1.71, 95% CI: 1.05, 2.82)更有可能缺乏艾滋病毒知识。结论:马来西亚总人口中四分之三的人被发现缺乏足够的艾滋病毒知识。这突出表明需要在艾滋病毒教育方面采取有针对性的干预措施,特别是在农村地区和受教育程度较低的人群中。此外,数字平台和以青年为重点的宣传活动在接触青少年方面可能特别有效。决策者必须优先考虑包容性和可及性的艾滋病毒预防战略,以解决这些差距并降低传播率。
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引用次数: 0
Effectiveness of low-fat diet on the levels of insulin-like growth factor-1 and insulin-like growth factor binding proteins: a systematic review and meta-analysis of randomized controlled clinical trials. 低脂饮食对胰岛素样生长因子-1和胰岛素样生长因子结合蛋白水平的影响:随机对照临床试验的系统回顾和荟萃分析
IF 2.4 3区 医学 Q3 ENVIRONMENTAL SCIENCES Pub Date : 2024-11-29 DOI: 10.1186/s41043-024-00698-x
Zohreh Sadat Sangsefidi, Sepideh Soltani, Fatemeh Meshkini, Kimia Torabynasab, Sheida Zeraattalab-Motlagh, Elham Razmpoosh, Mahdi Hejazi, Masoumeh Khalighi Sikaroudi, Shima Abdollahi

Background: Previous researches on the effect of low-fat diet (LF) on insulin-like growth factor-1 (IGF-1), and its binding proteins (IGFBPs) did not reach a consensus result, and there is no study summarizing these findings. Thus, this systematic review and meta-analysis of randomized control trials (RCTs) was performed to pool available evidence and answer the question whether dietary fat can affect IGF-1 and IGFBPs or not.

Methods: PubMed, Scopus, ISI Web of Science, Google, Google scholar, ProQuest, and the Cochrane Library were searched without language restrictions until July 2, 2024 to retrieve related studies. Weighted mean difference and the corresponding variance were considered as the effect size. Standard tools were applied to assess the quality of the studies and evidence.

Results: Pooling data of the eligible studies showed no significant effect of LF diet on IGF-1 (six studies; participants = 1029.; pooled mean = 1.63 ng/ml, 95% CI= [-1.34, 4.59], P = 0.28, I2 = 0.00%), and IGFBP-3 (five studies; participants = 969; pooled mean = 65.24 ng/ml, 95% CI= [-169.53, 300.00], P = 0.59, I2 = 0.0%). The results of subgroup analysis for IGF-1 and IGFBP-3 also demonstrated no significant findings. For IGFBP-1, available evidence is insufficient since only two studies have been performed yet and their results are contradictory.

Conclusions: This study indicated no significant effect of LF diet on IGF-1, and IGFBP-3 concentrations. Low certainty of evidence indicates that available evidence cannot support to draw a firm conclusion and future researches may change the estimates.

背景:以往关于低脂饮食(LF)对胰岛素样生长因子-1 (IGF-1)及其结合蛋白(igfbp)影响的研究没有达成一致的结果,也没有对这些发现进行总结的研究。因此,本研究对随机对照试验(rct)进行了系统回顾和荟萃分析,以汇集现有证据,并回答膳食脂肪是否会影响IGF-1和igfbp的问题。方法:截止到2024年7月2日,检索PubMed、Scopus、ISI Web of Science、谷歌、谷歌scholar、ProQuest和Cochrane Library,检索相关研究,不受语言限制。加权平均差和相应的方差被认为是效应大小。采用标准工具评估研究和证据的质量。结果:合并符合条件的研究数据显示,低脂饮食对IGF-1没有显著影响(6项研究;参与者= 1029.;池意味着= 1.63 ng / ml, 95% CI = [-1.34, 4.59], P = 0.28, I2 = 0.00%),和IGFBP-3(五个研究;参与者= 969人;池意味着= 65.24 ng / ml, 95% CI = [-169.53, 300.00], I2 = 0.0%, P = 0.59)。IGF-1和IGFBP-3的亚组分析结果也没有明显的发现。对于IGFBP-1,现有证据不足,因为目前只进行了两项研究,其结果相互矛盾。结论:本研究提示低脂饮食对IGF-1和IGFBP-3浓度无显著影响。证据的低确定性表明现有证据不能支持得出确切的结论,未来的研究可能会改变估计。
{"title":"Effectiveness of low-fat diet on the levels of insulin-like growth factor-1 and insulin-like growth factor binding proteins: a systematic review and meta-analysis of randomized controlled clinical trials.","authors":"Zohreh Sadat Sangsefidi, Sepideh Soltani, Fatemeh Meshkini, Kimia Torabynasab, Sheida Zeraattalab-Motlagh, Elham Razmpoosh, Mahdi Hejazi, Masoumeh Khalighi Sikaroudi, Shima Abdollahi","doi":"10.1186/s41043-024-00698-x","DOIUrl":"10.1186/s41043-024-00698-x","url":null,"abstract":"<p><strong>Background: </strong>Previous researches on the effect of low-fat diet (LF) on insulin-like growth factor-1 (IGF-1), and its binding proteins (IGFBPs) did not reach a consensus result, and there is no study summarizing these findings. Thus, this systematic review and meta-analysis of randomized control trials (RCTs) was performed to pool available evidence and answer the question whether dietary fat can affect IGF-1 and IGFBPs or not.</p><p><strong>Methods: </strong>PubMed, Scopus, ISI Web of Science, Google, Google scholar, ProQuest, and the Cochrane Library were searched without language restrictions until July 2, 2024 to retrieve related studies. Weighted mean difference and the corresponding variance were considered as the effect size. Standard tools were applied to assess the quality of the studies and evidence.</p><p><strong>Results: </strong>Pooling data of the eligible studies showed no significant effect of LF diet on IGF-1 (six studies; participants = 1029.; pooled mean = 1.63 ng/ml, 95% CI= [-1.34, 4.59], P = 0.28, I<sup>2</sup> = 0.00%), and IGFBP-3 (five studies; participants = 969; pooled mean = 65.24 ng/ml, 95% CI= [-169.53, 300.00], P = 0.59, I<sup>2</sup> = 0.0%). The results of subgroup analysis for IGF-1 and IGFBP-3 also demonstrated no significant findings. For IGFBP-1, available evidence is insufficient since only two studies have been performed yet and their results are contradictory.</p><p><strong>Conclusions: </strong>This study indicated no significant effect of LF diet on IGF-1, and IGFBP-3 concentrations. Low certainty of evidence indicates that available evidence cannot support to draw a firm conclusion and future researches may change the estimates.</p>","PeriodicalId":15969,"journal":{"name":"Journal of Health, Population, and Nutrition","volume":"43 1","pages":"201"},"PeriodicalIF":2.4,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11607937/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142755150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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Journal of Health, Population, and Nutrition
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