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Investigation of Microbial Contamination Prevalence in Four Medicinal Plant Species from the Lamiaceae Family in Herbal stores in Rasht City 拉什特市草药店中拉米亚科四种药用植物微生物污染流行情况调查
Pub Date : 2024-03-01 DOI: 10.32598/jgums.33.1.1882.1
Z. Hesari, Masoumeh Rohani, S. Parvinroo, Elahe Rafiei
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引用次数: 0
Preparation, Investigation of Physicochemical Properties and Stability of Azelaic Acid Gel Formulation 壬二酸凝胶配方的制备、理化性质和稳定性研究
Pub Date : 2024-03-01 DOI: 10.32598/jgums.33.1.495.1
Saeed Ghasemi, Zahra Sabour, Mohammad Moazen, Saeed Manoochehri
Background Rosacea as a skin inflammatory disease may be triggered by some types of bacteria. Azelaic acid with antibacterial property can be used for treatment of skin conditions such as Rosacea. Objective In this study, we aim to prepare and evaluate the physicochemical properties and primary stability of 15% azelaic acid gel. Methods For the gel preparation, first, an aqueous solution containing ethylenediaminetetraacetic and benzoic acids was prepared. Then, a mixture of polysorbate 80 and triglyceride was added to the solution at 50°C. Then, lecithin, propylene glycol, and carbomer 940 P was added to the mixture, and stirred. After that, the gel was prepared. Then, 15 g of dissolved azelaic acid in propylene glycol was added to the gel. Finally, the formulation was homogenized for 15 min. Results
背景 红斑痤疮是一种皮肤炎症,可能由某些类型的细菌引发。具有抗菌特性的壬二酸可用于治疗酒糟鼻等皮肤病。目的 本研究旨在制备和评估 15%壬二酸凝胶的理化性质和主要稳定性。方法 首先,制备含有乙二胺四乙酸和苯甲酸的水溶液。然后,在 50°C 下向溶液中加入聚山梨醇酯 80 和甘油三酯的混合物。然后,向混合物中加入卵磷脂、丙二醇和卡波姆 940 P,并进行搅拌。然后制备凝胶。然后,在凝胶中加入 15 克溶于丙二醇的杜鹃花酸。最后,将配方均质 15 分钟。结果
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引用次数: 0
Investigating the Antidepressant and Antioxidant Activity of the Alcoholic Extract of Melilotus Officinalis L. in Male Rats 研究雄性大鼠服用香叶木醇提取物的抗抑郁和抗氧化活性
Pub Date : 2024-03-01 DOI: 10.32598/jgums.33.1.2107.1
R. Parandin, F. Abbasi
Background Depression is one of the most common psychological disorders that can affect a person’s mood and change his/her perception of the self and environment. Melilotus officinalis L. plant contains effective substances and antioxidant compounds. Objective The present study aims to investigate the antidepressant effects of alcoholic extract of Melilotus officinalis L. in male rats. Methods In this experimental research, 42 male rats were divided into six groups of 7 including control (normal saline), negative control (reserpine), positive control (reserpine+fluoxetine) and three reserpine groups treated by intraperitoneal injection of 100, 200, 400 mg/kg doses of alcoholic extract of Melilotus officinalis L. Behavioral tests including forced swim test (FST) and tail suspension test (TST) were used to evaluate depression, and the antioxidant capacity and malondialdehyde level were also measured. The data were analyzed in SPSS software, version 20 using one-way analysis of variance. The significance level was set at P<0.05. Results The 200 mg/kg and 400 mg/kg doses of alcoholic extract significantly reduced the duration of immobility in the FST compared to the negative control. In the TST, the doses of 200 and 400 mg/kg showed a significant increase compared to the negative control. The doses of 200 and 400 mg/kg significantly increased the antioxidant capacity of the brain compared to the negative control. The doses of 200 and 400 mg/kg significantly reduced the antioxidant capacity of the brain compared to the negative control. Conclusion The alcoholic extract of Melilotus officinalis L has antidepressant effects similar to fluoxetine probably due to its antioxidant compounds.
背景 抑郁症是最常见的心理疾病之一,会影响人的情绪,改变人对自我和环境的认知。Melilotus officinalis L. 植物含有有效物质和抗氧化化合物。目的 本研究旨在探讨 Melilotus officinalis L. 酒精提取物对雄性大鼠的抗抑郁作用。方法 将42只雄性大鼠分为6组,每组7只,包括对照组(生理盐水)、阴性对照组(利眠宁)、阳性对照组(利眠宁+氟西汀)和3组利眠宁组。行为试验包括强迫游泳试验(FST)和尾悬试验(TST),以评估抑郁情况,并测定抗氧化能力和丙二醛水平。数据用 SPSS 软件 20 版进行单因素方差分析。显著性水平设定为 P<0.05。结果 与阴性对照组相比,200 毫克/千克和 400 毫克/千克剂量的酒精提取物能显著缩短 FST 的不动持续时间。在 TST 中,与阴性对照组相比,200 毫克/千克和 400 毫克/千克剂量的酒精提取物明显增加。与阴性对照组相比,200 毫克和 400 毫克/千克的剂量能明显提高大脑的抗氧化能力。与阴性对照组相比,200 毫克和 400 毫克/千克的剂量明显降低了大脑的抗氧化能力。结论 Melilotus officinalis L 的酒精提取物具有与氟西汀相似的抗抑郁作用,这可能是由于其抗氧化化合物的作用。
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引用次数: 0
The Frequency of Septal Abscess and Underlying Factors in Affected Patients in a Referral Hospital in North of Iran 伊朗北部一家转诊医院受影响患者的房间隔脓肿发生率及相关因素
Pub Date : 2024-03-01 DOI: 10.32598/jgums.33.1.1685.1
Sevil Nasirmohtaram, Maryam Akbari, M. Akbarpour, Farnaz Mazloom
Background Nasal septal abscess, which is the collection of purulent materials between the cartilaginous or bony septum and the mucoperichondrium or mucoperiosteum, often occurs after septal hematoma caused by trauma. Other common factors include surgery, foreign bodies, and sinusitis. In addition to the risk of nasal deformity, septal abscess can cause life-threatening complications such as osteomyelitis, orbital or intracerebral abscess. Objective This study aims to investigate the frequency of nasal septal abscess and its related factors in patients in north of Iran. Methods In this descriptive cross-sectional study on the patients referred to a hospital in north of Iran in 2022. Their demographic and disease-related information were recorded and the risk factors were finally identified. Results In this study, 37 patients had septal abscess. The most common risk factor identified was a his - tory of septoplasty or septorhinoplasty (35.1%), followed by diabetes mellitus (21.6%). Surprisingly, one of the factors in these patients was cauterization for epistaxis treatment (n=6). All patients were treated with broad-spectrum antibiotics and surgical drainage. In five patients, abscess resulted in saddle nose deformity. Positive culture results were reported in five samples
背景 鼻中隔脓肿是软骨或骨性鼻中隔与粘骨膜或粘骨膜之间的化脓性物质聚集,通常发生在外伤引起鼻中隔血肿之后。其他常见因素包括手术、异物和鼻窦炎。鼻中隔脓肿除了可能导致鼻部畸形外,还可能引起骨髓炎、眶内或脑内脓肿等危及生命的并发症。目的 本研究旨在调查伊朗北部患者患鼻中隔脓肿的频率及其相关因素。方法 在这项描述性横断面研究中,研究对象是 2022 年转诊到伊朗北部一家医院的患者。研究记录了他们的人口统计学和疾病相关信息,并最终确定了风险因素。结果 在这项研究中,37 名患者患有房间隔脓肿。最常见的风险因素是鼻中隔成形术或鼻中隔成形术(35.1%),其次是糖尿病(21.6%)。令人惊讶的是,这些患者中的一个因素是鼻衄治疗烧灼术(6 人)。所有患者均接受了广谱抗生素治疗和手术引流。五名患者的脓肿导致鞍鼻畸形。五个样本的培养结果呈阳性
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引用次数: 0
Efficacy of low-level laser therapy in the treatment of Temporomandibular disorders. 低强度激光疗法治疗颞下颌关节紊乱症的疗效。
Pub Date : 2024-03-01 DOI: 10.32598/jgums.33.1.1
Mahsa Koochaki, A. Hendi, Bahare Mahmoudpour, Sina Sarlak
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引用次数: 0
Professional Autonomy and Safe Nursing Care in Newly Graduated Nurses Working in Emergency Departments 急诊科新毕业护士的专业自主与安全护理
Pub Date : 2024-03-01 DOI: 10.32598/jgums.33.1.541.1
Leila Rouhi Balasi, Hasan Shafaati Shamami, Ali Alizadeh, Sadegh Pasandidehfar, Mojtaba Makhsoos, Ahmad Gholami
Background It is necessary to provide safe care for patients with acute and life-threatening conditions by nurses working in the emergency departments (EDs). These nurses need higher levels of independent performance. Therefore, the competency to provide safe care and having professional nursing autonomy in novice nurses working in the EDs are very important. Objective The purpose of this study was to determine the relationship between professional nursing autonomy and safe nursing care in newly graduated nurses working in the EDs. Methods In this analytical cross-sectional study, the study population consists of all newly graduated nurses working in EDs of hospitals in Guilan, Iran. They all were included in the study using a census sampling method. The tools for collecting information were a demographic form, the assessment of safe nursing care questionnaire, and the professional nursing autonomy scale. Descriptive and inferential statistics (independent t-test, Spearman or Pearson correlation test, and linear regression analysis) were used to analyze the collected data. Results There was a significant relationship between professional nursing autonomy and safe nursing care; for every one unit increase in professional autonomy, the chance of providing safe nursing care increases by 0.133 (P=0.009). Conclusion The significant relationship of professional nursing autonomy with safe nursing care among the EDS nurses shows that if nurses have a greater control over their performance, decision-making ability, and autonomy to act based on patient safety, they can provide better quality care to patients. Therefore, empowering nurses by providing conditions to perform based on professional autonomy, can ultimately lead to better results for the patients and cause overall safety in the EDs.
背景 在急诊科(ED)工作的护士有必要为危及生命的急症患者提供安全护理。这些护士需要更高水平的独立工作能力。因此,在急诊科工作的新手护士提供安全护理的能力和专业护理自主权非常重要。目的 本研究旨在确定在急诊室工作的新毕业护士的专业护理自主性与安全护理之间的关系。方法 在这项分析性横断面研究中,研究对象包括在伊朗吉兰省医院急诊室工作的所有新毕业护士。研究采用普查抽样法将他们全部纳入研究范围。收集信息的工具包括人口统计学表格、安全护理评估问卷和专业护理自主性量表。研究采用描述性和推论性统计(独立 t 检验、Spearman 或 Pearson 相关性检验和线性回归分析)对收集的数据进行分析。结果 专业护理自主性与安全护理之间存在显著关系;专业自主性每增加一个单位,提供安全护理的几率就会增加 0.133(P=0.009)。结论 EDS 护士的专业护理自主权与安全护理之间的显着关系表明,如果护士对自己的工作表现、决策能力和基于患者安全的行动自主权有更大的控制能力,就能为患者提供更优质的护理服务。因此,通过提供基于专业自主性的执行条件来增强护士的能力,最终可以为患者带来更好的结果,并确保急诊室的整体安全。
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引用次数: 0
Designing The Model Of Institutionalization Of Transparency Culture In Lorestan University Of Medical Sciences In 2023 设计 2023 年洛雷斯坦医科大学透明文化制度化模式
Pub Date : 2024-03-01 DOI: 10.32598/jgums.33.1.2219.1
Mohsen Amirinia, Reza Sepahvand1, Mohammad Hakkak1, Seyed Najmoddin Mousavi1
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引用次数: 0
The Potential of Tissue Engineering in Treatment of Female Reproductive System Disorders: A Review 组织工程在治疗女性生殖系统疾病中的潜力:综述
Pub Date : 2024-03-01 DOI: 10.32598/jgums.33.1.2082.1
Tayebeh Sadat Tabataba'i, zahra khosravizadeh, Zahra Nikoozad, majid salehi, Morteza Alizadeh, Ali Talebi
Background Recent advances in the field of reproductive biology through tissue engineering have greatly contributed to infertility health care and treatment. Current studies on the bioengineering of female genital tissues has created new hopes for people suffering from congenital and acquired reproductive tract disorders and infertility. Objective This study aims to review the biological materials and strategies employed in the tissue engineering of female reproductive organs and tissues. Methods In this study, articles were searched using the keywords “infertility”, “tissue engineering”, “female reproductive organs”, “vagina”, “uterus”, “ovary” and “follicle” independently in Web of Science, PubMed, Scopus, ScienceDirect and Google scholar databases. Finally 82 articles were selected and reviewed
背景 通过组织工程学在生殖生物学领域取得的最新进展极大地促进了不孕症的保健和治疗。目前对女性生殖器官组织生物工程的研究为先天性和后天性生殖道疾病和不孕症患者带来了新的希望。目的 本研究旨在综述女性生殖器官组织工程中使用的生物材料和策略。方法 本研究以 "不孕症"、"组织工程"、"女性生殖器官"、"阴道"、"子宫"、"卵巢 "和 "卵泡 "为关键词,分别在 Web of Science、PubMed、Scopus、ScienceDirect 和 Google scholar 数据库中进行检索。最后筛选出 82 篇文章并进行了审查
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引用次数: 0
Molecular Factors Affecting Embryo Implantation: A Narrative Review 影响胚胎植入的分子因素:叙述性综述
Pub Date : 2024-01-01 DOI: 10.32598/jgums.32.4.2105.1
Leila Rezakhani, Mohammad Rsool Khazaei, A. Faramarzi, Mozafar Khazaei
Background: Embryo implantation involves the interaction between the blastocyst and the host uterus that occurs over a limited period called the implantation window. Objective: The present study was conducted to investigate the factors involved in embryo implantation. Methods: In this review study, to review the effective factors in implantation, Persian and English articles from databases such as PubMed, Scopus, Science Direct, Google Scholar, and MagIran from 2000 to 2022 using the keywords of embryo implantation, effective factors in implantation and infertility were investigated. Results: Uterine receptivity for embryo implantation is regulated by the ovarian hormones estrogen and progesterone. Defects in the regulation of cytokine expression will lead to incomplete implantation failure. The potential role of growth factors such as leukemia inhibitory factor, interleukin-1, interleukin-6, interleukin-11, colony stimulating factor-1, epidermal growth factor family, and insulin-like factor in the important implantation process has been described. HOX genes are transcriptional regulators that play an essential role during embryonic development and continue to be expressed in the development of primary female reproductive tract tubes and then in the adult uterus. The role of morphogens in implantation has been proven and they are effective in embryo-uterine interactions during this process. Conclusion: Understanding the biology of implantation can reduce female infertility and help develop new therapies for fertility.
背景:胚胎植入涉及囊胚与宿主子宫之间的相互作用,这种相互作用发生在一个被称为植入窗的有限时期内。研究目的本研究旨在探讨胚胎植入的相关因素。研究方法在这项综述性研究中,为了对胚胎植入的有效因素进行综述,研究人员使用胚胎植入、植入的有效因素和不孕症等关键词,对 2000 年至 2022 年期间来自 PubMed、Scopus、Science Direct、Google Scholar 和 MagIran 等数据库的波斯语和英语文章进行了调查。研究结果子宫对胚胎植入的接受能力受卵巢激素雌激素和孕激素的调节。细胞因子表达调控的缺陷将导致不完全着床失败。白血病抑制因子、白细胞介素-1、白细胞介素-6、白细胞介素-11、集落刺激因子-1、表皮生长因子家族和胰岛素样因子等生长因子在重要的着床过程中的潜在作用已得到描述。HOX 基因是一种转录调节因子,在胚胎发育过程中发挥着重要作用,并在初级女性生殖道输卵管的发育过程中以及成年子宫中继续表达。形态发生因子在植入过程中的作用已得到证实,它们在这一过程中能有效地促进胚胎与子宫之间的相互作用。结论了解着床的生物学原理可减少女性不孕症的发生,并有助于开发新的生育疗法。
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引用次数: 0
Effect of Schema Therapy on Using Adaptive and Maladaptive Cognitive-Emotion Regulation Strategies in People With HIV 模式疗法对艾滋病毒感染者使用适应性和不适应性认知-情绪调节策略的影响
Pub Date : 2024-01-01 DOI: 10.32598/jgums.32.4.2115.1
Maryamsadat Mostafa, M. Sedaghat, Shahrokh Makvand hoseini, Seyed ahmad Alinaghi
Background: The human immunodeficiency virus (HIV) is important because of the social and labeling problems, and the prevalence of a variety of psychological, family, and social problems can be observed in these individuals. Objective: The aim of this study, in order to promote mental health, is to investigate the effectiveness of schema therapy on adaptive and maladaptive strategies of cognitive-emotional regulation of people living with HIV (PLWH). Methods: The research is an interventional study that used a pretest-posttest design and control group. Thirty people were selected by convenience sampling method and randomly divided into two groups, experimental and control. Garnefski et al.'s cognitive-emotional regulation (CERQ-SF) questionnaire was used. The experimental group received ten two-hour sessions of group treatment with Young's schema therapy model. To analyze the data, mean and standard deviation (SD) and analysis of covariance were used by SPSS 26 and P<0/05. Results: The results analysis of covariance showed that group treatment schema therapy improved the extent of adaptive strategies (acceptance, positive refocusing, refocusing on planning, positive reappraisal, and broader perspective) and maladaptive strategies (self-blame and catastrophic perception), (p<0.001), However, there was not any improve in terms of blaming others, (P<0/033) and rumination (P<0/102). Conclusion: Schema therapy has increased the use of adaptive strategies and decreased maladaptive cognitive-emotional strategies (self-blame and catastrophic perception) in PLWH.
背景:人类免疫缺陷病毒(HIV)之所以重要,是因为其社会和标签问题,在这些人身上可以观察到各种心理、家庭和社会问题的普遍性。目的:为了促进心理健康,本研究旨在探讨模式疗法对 HIV 感染者(PLWH)认知情绪调节的适应性和不适应性策略的有效性。研究方法本研究是一项干预性研究,采用前测-后测设计和对照组。研究采用方便抽样法选取 30 人,随机分为实验组和对照组。采用 Garnefski 等人的认知情绪调节(CERQ-SF)问卷。实验组接受十次两小时的杨氏模式治疗小组治疗。数据分析采用 SPSS 26 的平均值、标准差(SD)和协方差分析,P<0/05。结果协方差分析结果显示,团体治疗模式疗法改善了适应性策略(接纳、积极重新聚焦、重新聚焦于计划、积极重新评估和更广阔的视角)和不良适应性策略(自责和灾难性认知)的程度(P<0.001),但在指责他人(P<0/033)和反刍(P<0/102)方面没有任何改善。结论模式疗法增加了 PLWH 适应性策略的使用,减少了不良认知情绪策略(自责和灾难性认知)的使用。
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引用次数: 0
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Journal of Guilan University of Medical Sciences
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