Pub Date : 2022-03-06DOI: 10.32598/jgums.30.4.1790.1
Roya Kaboodmehri, Zahra Rafiei Sorouri, Nasrin Ghanami Gashti, S. Sharami
Introduction: In women who are at risk for tuberculosis, the possibility of pelvic tuberculosis should always be considered along with other diagnoses. In virgin girls pelvic tuberculosis is rare, and due to nonspecific symptoms and radiographic studies, there is a possibility of misdiagnosis, and mortality so strong clinical suspicion, especially in girls exposed to tuberculosis is important in diagnosing the disease. Case presentation: This case report describes a 12 years old virgin girl with diffuse pelvic tuberculosis and peritonitis. In the examinations, there were tenderness and rebound in the abdominal examination and a fever of 38 degrees. Menarche was at the age of ten and the patient did not report menstrual irregularities. An ultrasound of the right ovary showed an 8 cm cystic mass with some fluid in the pelvis. Conclusion: Therefore, in women who are at risk for tuberculosis, the possibility of pelvic tuberculosis should always be considered along with other diagnoses.
{"title":"A Rare Case Report of Pelvic Tuberculosis in a 12 Years Old Virgin Girl","authors":"Roya Kaboodmehri, Zahra Rafiei Sorouri, Nasrin Ghanami Gashti, S. Sharami","doi":"10.32598/jgums.30.4.1790.1","DOIUrl":"https://doi.org/10.32598/jgums.30.4.1790.1","url":null,"abstract":"Introduction: In women who are at risk for tuberculosis, the possibility of pelvic tuberculosis should always be considered along with other diagnoses. In virgin girls pelvic tuberculosis is rare, and due to nonspecific symptoms and radiographic studies, there is a possibility of misdiagnosis, and mortality so strong clinical suspicion, especially in girls exposed to tuberculosis is important in diagnosing the disease. Case presentation: This case report describes a 12 years old virgin girl with diffuse pelvic tuberculosis and peritonitis. In the examinations, there were tenderness and rebound in the abdominal examination and a fever of 38 degrees. Menarche was at the age of ten and the patient did not report menstrual irregularities. An ultrasound of the right ovary showed an 8 cm cystic mass with some fluid in the pelvis. Conclusion: Therefore, in women who are at risk for tuberculosis, the possibility of pelvic tuberculosis should always be considered along with other diagnoses.","PeriodicalId":15994,"journal":{"name":"Journal of Guilan University of Medical Sciences","volume":"22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80095013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-06DOI: 10.32598/jgums.30.4.1724.1
Ali Pourramzani, Seyedeh Sara Alyasin, S. Saadat
Background: Perfectionism has positive and negative aspects that can have different consequences for students' personal and academic background. Objective: The aim of this study was to investigate the Perfectionism score and the role of demographic factors in general medicine interns. Materials and Methods: This cross-sectional study was conducted in the statistical population of general medicine interns of Guilan University of Medical Sciences in 2020. 200 of them participated in this study using the convenience sampling method and they answered the demographic questionnaire and the Multidimensional Perfectionism Scale; FMPS. Independent t-test and Mann-Whitney U test were used using SPSS-19 software. Results: The participation rate was 84.5% (169 people). The negative and positive perfectionism scores were (62.4±12.2) and (45.1±5.5). Students under the age of 25 had higher scores on the of concern over mistakes subscale (P=0.002). Male students had higher scores in the parental expectations (P=0.002) and personal standards (P=0.044). Married students scored higher in the parental expectations (P=0.031) and parental criticism (P=0.002) and lower scores in personal standards (P=0.002). Students with a history of physical illness had higher scores on the personal standards (P=0.006) and lower scores on the organization (P=0.045). In married students, more negative perfectionism (P=0.018) and less positive perfectionism (P=0.018) were reported. Conclusion: The results showed that the score of negative perfectionism is in the middle level and positive perfectionism is in the severe level and demographic factors such as young age, gender and marital status were effective on the components of perfectionism.
{"title":"Perfectionism in General Medicine Interns of Guilan University of Medical Sciences in 2021","authors":"Ali Pourramzani, Seyedeh Sara Alyasin, S. Saadat","doi":"10.32598/jgums.30.4.1724.1","DOIUrl":"https://doi.org/10.32598/jgums.30.4.1724.1","url":null,"abstract":"Background: Perfectionism has positive and negative aspects that can have different consequences for students' personal and academic background. Objective: The aim of this study was to investigate the Perfectionism score and the role of demographic factors in general medicine interns. Materials and Methods: This cross-sectional study was conducted in the statistical population of general medicine interns of Guilan University of Medical Sciences in 2020. 200 of them participated in this study using the convenience sampling method and they answered the demographic questionnaire and the Multidimensional Perfectionism Scale; FMPS. Independent t-test and Mann-Whitney U test were used using SPSS-19 software. Results: The participation rate was 84.5% (169 people). The negative and positive perfectionism scores were (62.4±12.2) and (45.1±5.5). Students under the age of 25 had higher scores on the of concern over mistakes subscale (P=0.002). Male students had higher scores in the parental expectations (P=0.002) and personal standards (P=0.044). Married students scored higher in the parental expectations (P=0.031) and parental criticism (P=0.002) and lower scores in personal standards (P=0.002). Students with a history of physical illness had higher scores on the personal standards (P=0.006) and lower scores on the organization (P=0.045). In married students, more negative perfectionism (P=0.018) and less positive perfectionism (P=0.018) were reported. Conclusion: The results showed that the score of negative perfectionism is in the middle level and positive perfectionism is in the severe level and demographic factors such as young age, gender and marital status were effective on the components of perfectionism.","PeriodicalId":15994,"journal":{"name":"Journal of Guilan University of Medical Sciences","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77727705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-06DOI: 10.32598/jgums.30.4.1748.1
F. Joukar, Iman Soufi Afshar, S. Yeganeh, M. Naghipour, A. Mansour-Ghanaei, F. Mansour-Ghanaei
Introduction: Laboratory studies have shown that gastric epithelial infection cells with Helicobacter pylori (H. pylori) infection increase the rate of autophagy. Disruption of this process causes various diseases, including cancer. Objective: This study aimed to evaluate the serum level of Autophagy -Related Gene 5 (ATG5) in individuals with and without H. pylori infection. Materials and Methods: This pilot cross-sectional analytical study was performed in 2018 for 44 individuals aged 35-50 years referred to the endoscopy ward of Razi Hospital of Rasht. Age, sex, body mass index, smoking, and symptoms were recorded in a questionnaire. Based on rapid urease test and pathology in two groups of 22 people, the presence and absence of H. pylori infection were examined. Serum ATG5 levels were quantitatively assessed by ELISA with an EIAab kit made in the USA. Results: In this study, 56.8% were male, 77.3% were over 40 years old, 52.3% had a BMI of less than 5 and 70.5% were smokers. The mean (±SD) of ATG5 in individuals with, and without H. pylori were (63.5 ± 15.4) and (57.1 ± 18.9), respectively (P >0.05). The mean ATG5 factor was higher in women than men (P = 0.047). Conclusion: In the present study, ATG5 was not significant in those with and without H. pylori. It is recommended a study be performed in larger sample size and based on a comparison of gastrointestinal lesions.
{"title":"Comparison of Serum Levels of Autophagy -Related Gene 5 in Patients With/ Without Helicobacter Pylori Infection","authors":"F. Joukar, Iman Soufi Afshar, S. Yeganeh, M. Naghipour, A. Mansour-Ghanaei, F. Mansour-Ghanaei","doi":"10.32598/jgums.30.4.1748.1","DOIUrl":"https://doi.org/10.32598/jgums.30.4.1748.1","url":null,"abstract":"Introduction: Laboratory studies have shown that gastric epithelial infection cells with Helicobacter pylori (H. pylori) infection increase the rate of autophagy. Disruption of this process causes various diseases, including cancer. Objective: This study aimed to evaluate the serum level of Autophagy -Related Gene 5 (ATG5) in individuals with and without H. pylori infection. Materials and Methods: This pilot cross-sectional analytical study was performed in 2018 for 44 individuals aged 35-50 years referred to the endoscopy ward of Razi Hospital of Rasht. Age, sex, body mass index, smoking, and symptoms were recorded in a questionnaire. Based on rapid urease test and pathology in two groups of 22 people, the presence and absence of H. pylori infection were examined. Serum ATG5 levels were quantitatively assessed by ELISA with an EIAab kit made in the USA. Results: In this study, 56.8% were male, 77.3% were over 40 years old, 52.3% had a BMI of less than 5 and 70.5% were smokers. The mean (±SD) of ATG5 in individuals with, and without H. pylori were (63.5 ± 15.4) and (57.1 ± 18.9), respectively (P >0.05). The mean ATG5 factor was higher in women than men (P = 0.047). Conclusion: In the present study, ATG5 was not significant in those with and without H. pylori. It is recommended a study be performed in larger sample size and based on a comparison of gastrointestinal lesions.","PeriodicalId":15994,"journal":{"name":"Journal of Guilan University of Medical Sciences","volume":"75 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86417201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-10-01DOI: 10.32598/jgums.30.3.1800.1
Yousef Alizadeh, Hassan Behboudi, Setila Dalili, A. Hassanzadeh Rad
Background: Obesity is a chronic metabolic disease that has become an epidemic today. Objective: Although the effects of obesity on the body have been well studied, less is known about obesity and eye health. Methods The present article is a review study. The search was performed using keywords of obesity and eye diseases in PubMed, Scopus, Web of Science databases from 2000 to 2021. Results: Obesity is a significant public health problem, and its impact on eye health is increasing. So far, the association of obesity with dry eye, cataract, glaucoma, age-related macular degeneration, and diabetic retinopathy has been reported with varying degrees of certainty. Conclusion: If weight loss as a complementary treatment proves to be an effective way of delaying the onset or slowing the progression of eye diseases in obese people, physicians and patients are more likely to be more motivated to combat this public health problem.
背景:肥胖是一种慢性代谢性疾病，如今已成为一种流行病。目的:虽然肥胖对身体的影响已经得到了很好的研究，但人们对肥胖和眼睛健康的了解却很少。方法本文为综述性研究。使用2000年至2021年PubMed、Scopus、Web of Science数据库中的肥胖和眼病关键词进行搜索。结果:肥胖是一个重大的公共卫生问题，其对眼睛健康的影响越来越大。到目前为止，肥胖与干眼症、白内障、青光眼、年龄相关性黄斑变性和糖尿病性视网膜病变之间的关联已经有不同程度的确定性报道。结论:如果减肥作为一种辅助治疗被证明是一种有效的方法，可以延缓肥胖人群眼病的发病或减缓其发展，医生和患者就更有可能更积极地对抗这一公共卫生问题。
{"title":"Obesity and Eye Diseases","authors":"Yousef Alizadeh, Hassan Behboudi, Setila Dalili, A. Hassanzadeh Rad","doi":"10.32598/jgums.30.3.1800.1","DOIUrl":"https://doi.org/10.32598/jgums.30.3.1800.1","url":null,"abstract":"Background: Obesity is a chronic metabolic disease that has become an epidemic today. Objective: Although the effects of obesity on the body have been well studied, less is known about obesity and eye health. Methods The present article is a review study. The search was performed using keywords of obesity and eye diseases in PubMed, Scopus, Web of Science databases from 2000 to 2021. Results: Obesity is a significant public health problem, and its impact on eye health is increasing. So far, the association of obesity with dry eye, cataract, glaucoma, age-related macular degeneration, and diabetic retinopathy has been reported with varying degrees of certainty. Conclusion: If weight loss as a complementary treatment proves to be an effective way of delaying the onset or slowing the progression of eye diseases in obese people, physicians and patients are more likely to be more motivated to combat this public health problem.","PeriodicalId":15994,"journal":{"name":"Journal of Guilan University of Medical Sciences","volume":"81 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83900800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-10-01DOI: 10.32598/jgums.30.3.761.2
Ghasem Salehpour, C. Rahimi, N. Mohammadi, A. Asadi-Pooya
Background: Sleep and seizures can affect each other in different ways. Meanwhile, sleep disorders are among the most frequent complaints of patients with epileptic and non-epileptic seizures, with various health outcomes. Objective This study aimed to investigate the psychological symptoms and clinical indicators in patients with/without sleepiness with epileptic/non-epileptic seizures. Methods: The present study was a fundamental and descriptive (causal-comparative) research. The study population included all patients with epileptic seizures (temporal and generalized) and non-epileptic psychogenic seizures in Shiraz City, Iran. A total of 68 patients (in two groups with sleepiness and without sleepiness) were selected by the purposive sampling method. The study data were collected using the clinical and demographic inventory, Stanford sleepiness scale, Beck depression and anxiety inventory, perceived stress, mood disorder, bipolar spectrum diagnostic scale, global assessment of the severity of epilepsy, and global assessment of disability-related directly to seizures. The obtained data were analyzed by univariate analysis of covariance, Fisher exact test, and Mann–Whitney U test. Results: Analyses showed that patients with seizures who had sleepiness reported higher levels of depression, anxiety, and stress than patients without sleepiness (P<0.05). Also, patients with sleepiness suffer more than their counterparts from the symptoms of bipolar disorder I and II and assess the severity of disease and disability resulting from seizures as worse (P<0.05). Conclusion: Sleepiness in patients with epileptic and non-epileptic seizures is associated with increased psychological symptoms and disease severity.
{"title":"Psychological Symptoms and Clinical Indicators in Patients With and Without Sleepiness Suffering From Epileptic and Non-Epileptic Seizures","authors":"Ghasem Salehpour, C. Rahimi, N. Mohammadi, A. Asadi-Pooya","doi":"10.32598/jgums.30.3.761.2","DOIUrl":"https://doi.org/10.32598/jgums.30.3.761.2","url":null,"abstract":"Background: Sleep and seizures can affect each other in different ways. Meanwhile, sleep disorders are among the most frequent complaints of patients with epileptic and non-epileptic seizures, with various health outcomes. Objective This study aimed to investigate the psychological symptoms and clinical indicators in patients with/without sleepiness with epileptic/non-epileptic seizures. Methods: The present study was a fundamental and descriptive (causal-comparative) research. The study population included all patients with epileptic seizures (temporal and generalized) and non-epileptic psychogenic seizures in Shiraz City, Iran. A total of 68 patients (in two groups with sleepiness and without sleepiness) were selected by the purposive sampling method. The study data were collected using the clinical and demographic inventory, Stanford sleepiness scale, Beck depression and anxiety inventory, perceived stress, mood disorder, bipolar spectrum diagnostic scale, global assessment of the severity of epilepsy, and global assessment of disability-related directly to seizures. The obtained data were analyzed by univariate analysis of covariance, Fisher exact test, and Mann–Whitney U test. Results: Analyses showed that patients with seizures who had sleepiness reported higher levels of depression, anxiety, and stress than patients without sleepiness (P<0.05). Also, patients with sleepiness suffer more than their counterparts from the symptoms of bipolar disorder I and II and assess the severity of disease and disability resulting from seizures as worse (P<0.05). Conclusion: Sleepiness in patients with epileptic and non-epileptic seizures is associated with increased psychological symptoms and disease severity.","PeriodicalId":15994,"journal":{"name":"Journal of Guilan University of Medical Sciences","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91531594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-10-01DOI: 10.32598/jgums.30.3.1673.1
M. Baradaran, Maedeh Mirzaei Malati, Nasrin Parsamehr, Maryam Tahmasebi
Background: COVID-19 pandemic has adverse psychosocial effects on families around the world. This pandemic is important as women are more responsible for the health care issues of their families. Objective: This study aimed to examine the relationship of cognitive-emotional regulation and sense of meaning in the perceived stress caused by the COVID-19 among female students. Methods: This research is analytical, cross-sectional. Using convenience sampling process, 100 female students from Islamic Azad University, Lahijan Branch, Lahijan City, Iran, were selected in May 2020. The data were collected using cognitive-emotional regulation, the meaning of life, and perceived stress questionnaires. Then, the obtained data were analyzed by the Pearson correlation and multiple linear regression (backward computation) with SPSS version 20. Results: According to the correlational analysis, there were negative significant relationships between perceived stress and some of cognitive-emotional regulation’s subscales, such as reassessment (r= -0.226, P=0.005) the presence of meaning (r= -0.341, P=0.001) and the sense of meaning (r= -0.211, P=0.005). Also, there were positive significant relationships between perceived stress and acceptance (r=0.175, P=0.005) and blaming others (r= -0.236, P=0.001) and thought rumination (r= -0.224, P=0.001). Based on regression analysis result, the presence of meaning, reassessment and blaming others can explain 22% of changes in perceived stress (P<0.001). Conclusion: Based on the study's findings, using strategies for cognitive-emotional regulation and maintaining a sense of meaning in life can reduce the intensity of psychological burden in stressful situations.
{"title":"Stress, Cognitive- Emotional Regulation, and Sense of Meaning Among Female Students During the COVID-19 Pandemic: A Web-based Cross-Sectional Study","authors":"M. Baradaran, Maedeh Mirzaei Malati, Nasrin Parsamehr, Maryam Tahmasebi","doi":"10.32598/jgums.30.3.1673.1","DOIUrl":"https://doi.org/10.32598/jgums.30.3.1673.1","url":null,"abstract":"Background: COVID-19 pandemic has adverse psychosocial effects on families around the world. This pandemic is important as women are more responsible for the health care issues of their families. Objective: This study aimed to examine the relationship of cognitive-emotional regulation and sense of meaning in the perceived stress caused by the COVID-19 among female students. Methods: This research is analytical, cross-sectional. Using convenience sampling process, 100 female students from Islamic Azad University, Lahijan Branch, Lahijan City, Iran, were selected in May 2020. The data were collected using cognitive-emotional regulation, the meaning of life, and perceived stress questionnaires. Then, the obtained data were analyzed by the Pearson correlation and multiple linear regression (backward computation) with SPSS version 20. Results: According to the correlational analysis, there were negative significant relationships between perceived stress and some of cognitive-emotional regulation’s subscales, such as reassessment (r= -0.226, P=0.005) the presence of meaning (r= -0.341, P=0.001) and the sense of meaning (r= -0.211, P=0.005). Also, there were positive significant relationships between perceived stress and acceptance (r=0.175, P=0.005) and blaming others (r= -0.236, P=0.001) and thought rumination (r= -0.224, P=0.001). Based on regression analysis result, the presence of meaning, reassessment and blaming others can explain 22% of changes in perceived stress (P<0.001). Conclusion: Based on the study's findings, using strategies for cognitive-emotional regulation and maintaining a sense of meaning in life can reduce the intensity of psychological burden in stressful situations.","PeriodicalId":15994,"journal":{"name":"Journal of Guilan University of Medical Sciences","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88045075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-10-01DOI: 10.32598/jgums.30.3.940.2
S. Hosseini
Background: Diabetes is a common and non-communicable disease that is on the rise around the world due to the lifestyle and eating habits of people. Long-term complications of diabetes include retinopathy, neuropathy, nephropathy, cardiac symptoms, genitourinary symptoms, sexual symptoms, and cerebrovascular events. Based on the numerous studies to reduce the complications of diabetes, exercise and medicinal plants (due to not having the side effects of synthetic drugs) are the most important strategies to control blood glucose and hyperlipidemia; however, the simultaneous impact of these two interventions has recently been considered by researchers. Therefore, it seems necessary to review these studies in the field of sports nutrition and use these two interventions at the same time. Objective:This study aimed to review the effects of consuming 10 medicinal plants simultaneously with exercise. Methods We searched all databases, especially Web of Science, PubMed, SID, Magiran, with relevant keywords, such as "medicinal plant", "anti-diabetic component", "exercise", "training", "glycemic index", and "lipid profile", without time limit. The articles were then categorized based on exercise and herbs on carbohydrates and lipids metabolism. Results: According to the studies conducted in the databases, 564 articles related to exercise and medicinal plants were observed. However, according to the inclusion criteria (dealing with physical activity, medicinal plants, and also diabetes), 34 articles related to the effects of exercises and medicinal plants in diabetes status were selected. Among the obtained studies, 10 medicinal plants, most of which were studied simultaneously with exercises, were examined. The results showed that medicinal plants, with their antioxidant activity and mechanisms related to stimulating insulin secretion, control hyperlipidemia. They act along with exercise activities depending on the type, intensity, and duration and increase the body's antioxidant activity and glucose consumption in muscle via non-insulin-dependent pathways in diabetic conditions. Conclusion: It seems that due to the challenging nature of the exercise intervention, using plant antioxidants along with physical activity will lead to improved metabolic parameters in diabetic patients. However, to confirm the safety of consumption, besides examining the therapeutic effects of plants and their active compounds, their toxicity should also be investigated. Also, the small number of samples, failure to follow the long-term effects of simultaneous use of medical plants and exercise, and lack of precise diet control in human samples are limitations of this study. So conducting human studies in this area with caution and deleting the overcoming limitations is necessary for future research.
背景:糖尿病是一种常见的非传染性疾病，由于人们的生活方式和饮食习惯，糖尿病在世界范围内呈上升趋势。糖尿病的长期并发症包括视网膜病变、神经病变、肾病、心脏症状、泌尿生殖系统症状、性症状和脑血管事件。根据大量减少糖尿病并发症的研究，运动和药用植物(由于没有合成药物的副作用)是控制血糖和高脂血症的最重要策略;然而，这两种干预措施的同时影响最近被研究人员考虑。因此，有必要回顾运动营养领域的这些研究，并同时使用这两种干预措施。目的:探讨运动同时食用10种药用植物对人体健康的影响。方法对Web of Science、PubMed、SID、Magiran等数据库进行检索，检索关键词为“药用植物”、“抗糖尿病成分”、“运动”、“训练”、“血糖指数”、“血脂”等，检索时间不限。然后根据运动和草药对碳水化合物和脂质代谢进行分类。结果:通过对数据库的研究，共观察到与运动和药用植物相关的文献564篇。然而，根据纳入标准(涉及体育活动、药用植物和糖尿病)，选择了34篇与运动和药用植物对糖尿病状态的影响有关的文章。在获得的研究中，对10种药用植物进行了研究，其中大部分与运动同时进行。结果表明，药用植物具有抗氧化作用，其抑制高脂血症的机制与刺激胰岛素分泌有关。它们与运动活动一起作用，取决于运动的类型、强度和持续时间，并在糖尿病患者中通过非胰岛素依赖途径增加身体的抗氧化活性和肌肉中的葡萄糖消耗。结论:由于运动干预的挑战性，在运动的同时使用植物抗氧化剂似乎可以改善糖尿病患者的代谢参数。然而，为了确认食用的安全性，除了检查植物及其活性化合物的治疗效果外，还应调查它们的毒性。此外，样本数量少，未能跟踪同时使用药用植物和运动的长期影响，以及缺乏精确的饮食控制人类样本是本研究的局限性。因此，谨慎地开展这一领域的人体研究，删除克服的局限性，对未来的研究是必要的。
{"title":"A Review of the Interactive Effects of Exercise and Medicinal Plants on Glycemic Indices and Lipid Profile in Diabetes Mellitus","authors":"S. Hosseini","doi":"10.32598/jgums.30.3.940.2","DOIUrl":"https://doi.org/10.32598/jgums.30.3.940.2","url":null,"abstract":"Background: Diabetes is a common and non-communicable disease that is on the rise around the world due to the lifestyle and eating habits of people. Long-term complications of diabetes include retinopathy, neuropathy, nephropathy, cardiac symptoms, genitourinary symptoms, sexual symptoms, and cerebrovascular events. Based on the numerous studies to reduce the complications of diabetes, exercise and medicinal plants (due to not having the side effects of synthetic drugs) are the most important strategies to control blood glucose and hyperlipidemia; however, the simultaneous impact of these two interventions has recently been considered by researchers. Therefore, it seems necessary to review these studies in the field of sports nutrition and use these two interventions at the same time. Objective:This study aimed to review the effects of consuming 10 medicinal plants simultaneously with exercise. Methods We searched all databases, especially Web of Science, PubMed, SID, Magiran, with relevant keywords, such as \"medicinal plant\", \"anti-diabetic component\", \"exercise\", \"training\", \"glycemic index\", and \"lipid profile\", without time limit. The articles were then categorized based on exercise and herbs on carbohydrates and lipids metabolism. Results: According to the studies conducted in the databases, 564 articles related to exercise and medicinal plants were observed. However, according to the inclusion criteria (dealing with physical activity, medicinal plants, and also diabetes), 34 articles related to the effects of exercises and medicinal plants in diabetes status were selected. Among the obtained studies, 10 medicinal plants, most of which were studied simultaneously with exercises, were examined. The results showed that medicinal plants, with their antioxidant activity and mechanisms related to stimulating insulin secretion, control hyperlipidemia. They act along with exercise activities depending on the type, intensity, and duration and increase the body's antioxidant activity and glucose consumption in muscle via non-insulin-dependent pathways in diabetic conditions. Conclusion: It seems that due to the challenging nature of the exercise intervention, using plant antioxidants along with physical activity will lead to improved metabolic parameters in diabetic patients. However, to confirm the safety of consumption, besides examining the therapeutic effects of plants and their active compounds, their toxicity should also be investigated. Also, the small number of samples, failure to follow the long-term effects of simultaneous use of medical plants and exercise, and lack of precise diet control in human samples are limitations of this study. So conducting human studies in this area with caution and deleting the overcoming limitations is necessary for future research.","PeriodicalId":15994,"journal":{"name":"Journal of Guilan University of Medical Sciences","volume":"60 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84009094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-10-01DOI: 10.32598/jgums.30.3.220.4
M. Jalali, Ziba Zahiri Sorouri, Vahid Aghsaghloo, Hedieh Ramezani
Background: Iron Deficiency Anemia (IDA) is the most common form of anemia. Understanding the relationship between IDA and hearing loss may provide new insights into managing hearing loss. Objective This study aimed to investigate the relationship between IDA and hearing loss in women aged 12-45 years referred to Amir Al-Momenin and Al-Zahra hospitals in Rasht City, Iran. Methods: In this case-control study, 315 women aged 12-45 years with IDA and without IDA were included. Study groups were matched by age. The amount of hemoglobin (based on the last blood test in the past month) of the subjects was measured and recorded. IDA was considered when the hemoglobin level was less than 12 mg/dL. Audiometry was performed for all participants. Results: In total, 169 individuals in the case group and 146 individuals in the control group participated in the study. The mean±SD hemoglobin level in the case and control groups were 10.9±1.36 and 12.67±1.47 mg/dL, respectively. There were higher hearing thresholds in low and high frequencies among the case group than the controls (P=0.002 and P=0.032, respectively). Logistic regression analysis after age adjusting showed odds of abnormal Distortion Product Otoacoustic Emissions (DPOAE) in the frequencies of 750 Hz and 1000 Hz more than 2 times in women with IDA compared to controls (OR= 2.21, P= 0.006 and OR= 2.40, P= 0.020, respectively). Conclusion: The study results showed a significant negative relationship between IDA and mean hearing threshold. Because of the high prevalence of IDA in women, this group may be at greater risk of hearing loss.
{"title":"A Comparative Study of Hearing Threshold in Women With and Without Iron Deficiency Anemia","authors":"M. Jalali, Ziba Zahiri Sorouri, Vahid Aghsaghloo, Hedieh Ramezani","doi":"10.32598/jgums.30.3.220.4","DOIUrl":"https://doi.org/10.32598/jgums.30.3.220.4","url":null,"abstract":"Background: Iron Deficiency Anemia (IDA) is the most common form of anemia. Understanding the relationship between IDA and hearing loss may provide new insights into managing hearing loss. Objective This study aimed to investigate the relationship between IDA and hearing loss in women aged 12-45 years referred to Amir Al-Momenin and Al-Zahra hospitals in Rasht City, Iran. Methods: In this case-control study, 315 women aged 12-45 years with IDA and without IDA were included. Study groups were matched by age. The amount of hemoglobin (based on the last blood test in the past month) of the subjects was measured and recorded. IDA was considered when the hemoglobin level was less than 12 mg/dL. Audiometry was performed for all participants. Results: In total, 169 individuals in the case group and 146 individuals in the control group participated in the study. The mean±SD hemoglobin level in the case and control groups were 10.9±1.36 and 12.67±1.47 mg/dL, respectively. There were higher hearing thresholds in low and high frequencies among the case group than the controls (P=0.002 and P=0.032, respectively). Logistic regression analysis after age adjusting showed odds of abnormal Distortion Product Otoacoustic Emissions (DPOAE) in the frequencies of 750 Hz and 1000 Hz more than 2 times in women with IDA compared to controls (OR= 2.21, P= 0.006 and OR= 2.40, P= 0.020, respectively). Conclusion: The study results showed a significant negative relationship between IDA and mean hearing threshold. Because of the high prevalence of IDA in women, this group may be at greater risk of hearing loss.","PeriodicalId":15994,"journal":{"name":"Journal of Guilan University of Medical Sciences","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75172074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-10-01DOI: 10.32598/jgums.30.3.1609.2
A. Komaki, I. Salehi, Arman Keymoradzadeh, Masoumeh Taheri Azandaryani, Zoleikha Golipoor
Background: Recently, researchers have considered extremely low-frequency electromagnetic fields (ELF-EMFs), as one of the non-invasive therapies, in the treatment of many severe neurological disorders, including Alzheimer Disease (AD). AD is a progressive neurodegenerative disease characterized by the deposition of amyloid plaques in the brain. However, the increase in microglial cells increases phagocytosis and the destruction of amyloid plaques. Therefore, the present study aimed to investigate the amount of β-amyloid precursor deposition and the number of microglia cells in the animal model of AD before and after exposure to ELF-EMFs. Objective: The aim of this study was to investigate the deposition of beta ameloid precursor and the number of microglial cells in the Alzheimer's animal model before and after exposure to magnetic waves. Methods: Fifty male adult rats were randomly grouped into 5: The control group, the ELF-EMFs group, the AD group, the treatment group 1, and the treatment group 2. After the study period, the animals were killed for immunohistochemistry assessment to detect and compare the deposition of β-amyloid and the production of allograft inflammatory factor 1 (Iba1) protein. Results: Exposure to ELF reduced the deposition of β-amyloid and increased microglia cells. However, these changes were not different between the control and ELF-EMFs groups (P<0.001). Conclusion: ELF-EMF can reduce the formation of β-amyloid plaques and induce the proliferation of microglia cells. Therefore, they can be used to treat brain damage caused by Alzheimer disease.
{"title":"Effect of Long-term Exposure to Extremely Low-frequency Electromagnetic Fields on β-amyloid Deposition and Microglia Cells in an Alzheimer Model in Rats","authors":"A. Komaki, I. Salehi, Arman Keymoradzadeh, Masoumeh Taheri Azandaryani, Zoleikha Golipoor","doi":"10.32598/jgums.30.3.1609.2","DOIUrl":"https://doi.org/10.32598/jgums.30.3.1609.2","url":null,"abstract":"Background: Recently, researchers have considered extremely low-frequency electromagnetic fields (ELF-EMFs), as one of the non-invasive therapies, in the treatment of many severe neurological disorders, including Alzheimer Disease (AD). AD is a progressive neurodegenerative disease characterized by the deposition of amyloid plaques in the brain. However, the increase in microglial cells increases phagocytosis and the destruction of amyloid plaques. Therefore, the present study aimed to investigate the amount of β-amyloid precursor deposition and the number of microglia cells in the animal model of AD before and after exposure to ELF-EMFs. Objective: The aim of this study was to investigate the deposition of beta ameloid precursor and the number of microglial cells in the Alzheimer's animal model before and after exposure to magnetic waves. Methods: Fifty male adult rats were randomly grouped into 5: The control group, the ELF-EMFs group, the AD group, the treatment group 1, and the treatment group 2. After the study period, the animals were killed for immunohistochemistry assessment to detect and compare the deposition of β-amyloid and the production of allograft inflammatory factor 1 (Iba1) protein. Results: Exposure to ELF reduced the deposition of β-amyloid and increased microglia cells. However, these changes were not different between the control and ELF-EMFs groups (P<0.001). Conclusion: ELF-EMF can reduce the formation of β-amyloid plaques and induce the proliferation of microglia cells. Therefore, they can be used to treat brain damage caused by Alzheimer disease.","PeriodicalId":15994,"journal":{"name":"Journal of Guilan University of Medical Sciences","volume":"64 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74320869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-10-01DOI: 10.32598/jgums.30.3.1098.1
Saeede Rahmatpour, H. Saeidi Saedi, Mona Haddad Zahmatkesh
Background: Radiotherapy is one of the cancer treatment methods. Although radioresistance and normal tissue toxicity limit the radiation therapy in certain anatomical locations, using some substances can be useful to increase radiosensitivity on cancer cells without cytotoxicity effect on normal cells. Objective: This study aimed to evaluate the radiosensitizing effect of tolmetin in radiotherapy treatment on human colon cancer cell line HT-29. Methods In this study, human colon cancer cells HT-29 in different groups were irradiated with 4 Gy x-ray, and tolmetin was administered in different concentrations (75, 100, and 150 μM). Then, the groups were compared with each other and with the control group by Micronucleus Assay (MN) and Nuclear Division Index (NDI). NDI investigated the cytotoxicity, and MN indicated the genotoxicity. Results: In the group receiving radiation, micronuclei increased significantly compared to the control group. In the group receiving tolmetin with a concentration of 75 and 100 μM, the number of micronuclei also increased compared to the control group. In all groups treated with tolmetin that also received radiation, a significant increase in micronuclei was observed, which was more noticeable at concentrations of 100 and 150 μM. At the same time, tolmetin at the studied concentrations did not change the NDI index. Conclusion: The present study demonstrates that tolmetin has a radiosensitizing effect on HT-29 colon cancer cells, which depends on the tolmetin concentration. In addition, tolmetin has no cytotoxic effect on this cell line.
{"title":"Evaluation of Radiosensitive Effect of Tolmetin in Radiotherapy on Human Colonic Carcinoma Cell Line HT-29","authors":"Saeede Rahmatpour, H. Saeidi Saedi, Mona Haddad Zahmatkesh","doi":"10.32598/jgums.30.3.1098.1","DOIUrl":"https://doi.org/10.32598/jgums.30.3.1098.1","url":null,"abstract":"Background: Radiotherapy is one of the cancer treatment methods. Although radioresistance and normal tissue toxicity limit the radiation therapy in certain anatomical locations, using some substances can be useful to increase radiosensitivity on cancer cells without cytotoxicity effect on normal cells. Objective: This study aimed to evaluate the radiosensitizing effect of tolmetin in radiotherapy treatment on human colon cancer cell line HT-29. Methods In this study, human colon cancer cells HT-29 in different groups were irradiated with 4 Gy x-ray, and tolmetin was administered in different concentrations (75, 100, and 150 μM). Then, the groups were compared with each other and with the control group by Micronucleus Assay (MN) and Nuclear Division Index (NDI). NDI investigated the cytotoxicity, and MN indicated the genotoxicity. Results: In the group receiving radiation, micronuclei increased significantly compared to the control group. In the group receiving tolmetin with a concentration of 75 and 100 μM, the number of micronuclei also increased compared to the control group. In all groups treated with tolmetin that also received radiation, a significant increase in micronuclei was observed, which was more noticeable at concentrations of 100 and 150 μM. At the same time, tolmetin at the studied concentrations did not change the NDI index. Conclusion: The present study demonstrates that tolmetin has a radiosensitizing effect on HT-29 colon cancer cells, which depends on the tolmetin concentration. In addition, tolmetin has no cytotoxic effect on this cell line.","PeriodicalId":15994,"journal":{"name":"Journal of Guilan University of Medical Sciences","volume":"116 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76683672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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