{"title":"WHO's Global status report on neurology: mixed messages for people with headache disorders.","authors":"Timothy J Steiner, Latifa Adarmouch, Amalie Berring-Uldum, Raquel Gil-Gouveia, Rigmor Jensen, Risako Shirane, Andreas Kattem Husøy","doi":"10.1186/s10194-026-02281-7","DOIUrl":"10.1186/s10194-026-02281-7","url":null,"abstract":"","PeriodicalId":16013,"journal":{"name":"Journal of Headache and Pain","volume":"27 1","pages":"37"},"PeriodicalIF":7.9,"publicationDate":"2026-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12879461/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146125024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-03DOI: 10.1186/s10194-026-02284-4
Masahito Katsuki, Noboru Matsumoto, Yasuhiko Matsumori, Muneto Tatsumoto, Keisuke Suzuki, Tomokazu Shimazu, Miguel Á Huerta, Daiki Sato, Koki Kikugawa, Shigeharu Kamado, Siobhán O'Connor, Tomás Ward, Kieran Moran
{"title":"Interictal burden, not ictal burden, drives work productivity impairment in headache disorders: insights from a Japanese cross-sectional study.","authors":"Masahito Katsuki, Noboru Matsumoto, Yasuhiko Matsumori, Muneto Tatsumoto, Keisuke Suzuki, Tomokazu Shimazu, Miguel Á Huerta, Daiki Sato, Koki Kikugawa, Shigeharu Kamado, Siobhán O'Connor, Tomás Ward, Kieran Moran","doi":"10.1186/s10194-026-02284-4","DOIUrl":"https://doi.org/10.1186/s10194-026-02284-4","url":null,"abstract":"","PeriodicalId":16013,"journal":{"name":"Journal of Headache and Pain","volume":" ","pages":""},"PeriodicalIF":7.9,"publicationDate":"2026-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146113326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: Consequences of hearing abnormalities in migraine remain largely unexplored, particularly regarding peripheral outcomes. This study aims to explore how migraine induces peripheral auditory injury and what role calcitonin gene-related peptide (CGRP) plays in the inner ear, which may contribute to the precise subtyping of migraine and inform targeted auditory-protective therapies.
Methods: A mouse model of chronic migraine (CM) was established by intermittent injections of nitroglycerin and validated via mechanical and thermal nociceptive assays. CGRP signaling was assessed by Western blotting and immunofluorescence. Auditory function was evaluated using auditory brainstem response (ABR) and distortion product otoacoustic emissions (DPOAE) in CM and CGRP blockade (Rimegepant-treated) groups. RNA sequencing of cochlear tissue identified dysregulated signaling pathways, which were subsequently validated in vitro using HEI-OC1 auditory cells and in vivo within the inner ear.
Results: Repeated nitroglycerin injections induced persistent mechanical and thermal hyperalgesia, confirming successful model establishment. A significant upregulation of CGRP and its receptors, particularly in outer hair cells (OHCs) were confirmed. The CM mouse exhibited elevated ABR, DPOAE thresholds and OHC injury, all of which were mitigated by Rimegepant treatment. CGRP overstimulation triggered mitochondrial stress and mtDNA leakage in HEI-OC1 cells. Cytosolic mtDNA leakage activated the ZBP1-mediated PANoptosis pathway, leading to OHC injury. As proof of concept, ZBP1 knockdown and PANoptosis inhibition mitigated cellular damage and hearing deficits both in vivo and in vitro.
Conclusions: We demonstrated OHCs as the key targets in CM-induced, CGRP-mediated peripheral hearing impairment. CGRP exerts its pathogenic role by triggering a cascade of intracellular stress and inflammatory pathways, ultimately leading to cell death. These findings provide a phenotypic basis for a subtype of migraine-induced hearing loss, paving the way for auditory protection strategies.
{"title":"Migraine-induced cochlear injury triggers ZBP1-mediated PANoptosis via CGRP signaling.","authors":"Wandi Xu, Ni Zhai, Jingyu Chen, Shun Zhou, E Tian, Zhaoqi Guo, Zhanghong Zhou, Xixi Yu, Ziyu Zhai, Xin Zhang, Yixu Wang, Xin Ma, Yisheng Lu, Sulin Zhang","doi":"10.1186/s10194-026-02286-2","DOIUrl":"https://doi.org/10.1186/s10194-026-02286-2","url":null,"abstract":"<p><strong>Objective: </strong>Consequences of hearing abnormalities in migraine remain largely unexplored, particularly regarding peripheral outcomes. This study aims to explore how migraine induces peripheral auditory injury and what role calcitonin gene-related peptide (CGRP) plays in the inner ear, which may contribute to the precise subtyping of migraine and inform targeted auditory-protective therapies.</p><p><strong>Methods: </strong>A mouse model of chronic migraine (CM) was established by intermittent injections of nitroglycerin and validated via mechanical and thermal nociceptive assays. CGRP signaling was assessed by Western blotting and immunofluorescence. Auditory function was evaluated using auditory brainstem response (ABR) and distortion product otoacoustic emissions (DPOAE) in CM and CGRP blockade (Rimegepant-treated) groups. RNA sequencing of cochlear tissue identified dysregulated signaling pathways, which were subsequently validated in vitro using HEI-OC1 auditory cells and in vivo within the inner ear.</p><p><strong>Results: </strong>Repeated nitroglycerin injections induced persistent mechanical and thermal hyperalgesia, confirming successful model establishment. A significant upregulation of CGRP and its receptors, particularly in outer hair cells (OHCs) were confirmed. The CM mouse exhibited elevated ABR, DPOAE thresholds and OHC injury, all of which were mitigated by Rimegepant treatment. CGRP overstimulation triggered mitochondrial stress and mtDNA leakage in HEI-OC1 cells. Cytosolic mtDNA leakage activated the ZBP1-mediated PANoptosis pathway, leading to OHC injury. As proof of concept, ZBP1 knockdown and PANoptosis inhibition mitigated cellular damage and hearing deficits both in vivo and in vitro.</p><p><strong>Conclusions: </strong>We demonstrated OHCs as the key targets in CM-induced, CGRP-mediated peripheral hearing impairment. CGRP exerts its pathogenic role by triggering a cascade of intracellular stress and inflammatory pathways, ultimately leading to cell death. These findings provide a phenotypic basis for a subtype of migraine-induced hearing loss, paving the way for auditory protection strategies.</p>","PeriodicalId":16013,"journal":{"name":"Journal of Headache and Pain","volume":" ","pages":""},"PeriodicalIF":7.9,"publicationDate":"2026-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146106025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-31DOI: 10.1186/s10194-026-02277-3
Piero Barbanti, Gabriella Egeo, Alberto Doretti, Francesca Pistoia, Steno Rinalduzzi, Silvia Strumia, Cinzia Aurilia, Paola Scatena, Massimo Autunno, Antonio Salerno, Alberto Galli, Riccardo Altavilla, Stefano Messina, Carla Zanferrari, Pietrantonio Bruno, Cecilia Camarda, Florindo D'Onofrio, Veronica Iovine, Angelo Ranieri, Francesco Bono, Jesuély Spieckert de Souza, Antonio Carnevale, Laura Di Clemente, Maurizio Zucco, Francesco Baldisserri, Luisa Vinciguerra, Laura Borrello, Giulia Fiorentini, Rosario Vecchio, Valeria Drago, Paola Torelli, Maria Albanese, Carlo Tomino, Stefano Bonassi, Annamaria Porreca
{"title":"Responders and super-responders to atogepant after 24 weeks of treatment in migraine: real-world evidence from the GIANT-2 study.","authors":"Piero Barbanti, Gabriella Egeo, Alberto Doretti, Francesca Pistoia, Steno Rinalduzzi, Silvia Strumia, Cinzia Aurilia, Paola Scatena, Massimo Autunno, Antonio Salerno, Alberto Galli, Riccardo Altavilla, Stefano Messina, Carla Zanferrari, Pietrantonio Bruno, Cecilia Camarda, Florindo D'Onofrio, Veronica Iovine, Angelo Ranieri, Francesco Bono, Jesuély Spieckert de Souza, Antonio Carnevale, Laura Di Clemente, Maurizio Zucco, Francesco Baldisserri, Luisa Vinciguerra, Laura Borrello, Giulia Fiorentini, Rosario Vecchio, Valeria Drago, Paola Torelli, Maria Albanese, Carlo Tomino, Stefano Bonassi, Annamaria Porreca","doi":"10.1186/s10194-026-02277-3","DOIUrl":"https://doi.org/10.1186/s10194-026-02277-3","url":null,"abstract":"","PeriodicalId":16013,"journal":{"name":"Journal of Headache and Pain","volume":" ","pages":""},"PeriodicalIF":7.9,"publicationDate":"2026-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146097076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-30DOI: 10.1186/s10194-026-02283-5
Marina Romozzi, Matteo Palermo, Daisuke Danno, Masahito Katsuki, Federico Tosto, Francesco Signorelli, Catello Vollono, Yasuhiko Matsumori, Paolo Calabresi, Raffaele Ornello, Luigi Francesco Iannone
{"title":"Effectiveness and safety of anti-CGRP monoclonal antibodies in hemiplegic migraine: an individual patient quantitative analysis.","authors":"Marina Romozzi, Matteo Palermo, Daisuke Danno, Masahito Katsuki, Federico Tosto, Francesco Signorelli, Catello Vollono, Yasuhiko Matsumori, Paolo Calabresi, Raffaele Ornello, Luigi Francesco Iannone","doi":"10.1186/s10194-026-02283-5","DOIUrl":"https://doi.org/10.1186/s10194-026-02283-5","url":null,"abstract":"","PeriodicalId":16013,"journal":{"name":"Journal of Headache and Pain","volume":" ","pages":""},"PeriodicalIF":7.9,"publicationDate":"2026-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146093155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Prediction of medication overuse in patients with migraine using cox regression and machine learning: a real-world cohort.","authors":"Teerapong Aramruang, Pawin Numthavaj, Panu Looareesuwan, Thunyarat Anothaisintawee, Patratorn Kunakorntham, Oraluck Pattanaprateep, Charungthai Dejthevaporn, Ammarin Thakkinstian","doi":"10.1186/s10194-026-02269-3","DOIUrl":"https://doi.org/10.1186/s10194-026-02269-3","url":null,"abstract":"","PeriodicalId":16013,"journal":{"name":"Journal of Headache and Pain","volume":" ","pages":""},"PeriodicalIF":7.9,"publicationDate":"2026-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146044223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
扫码关注我们
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号