Pub Date : 2026-03-10DOI: 10.1186/s10194-026-02322-1
Sofia Nordenmalm, Rickard E Malmström, Sara Freyland, A Ingela M Nilsson Remahl, Karin Wirdefeldt, Isabella Ekheden
{"title":"Prescriber adherence to treatment guidelines for monoclonal antibodies against Calcitonin Gene-Related Peptide in migraine prophylaxis - a register-based cohort study.","authors":"Sofia Nordenmalm, Rickard E Malmström, Sara Freyland, A Ingela M Nilsson Remahl, Karin Wirdefeldt, Isabella Ekheden","doi":"10.1186/s10194-026-02322-1","DOIUrl":"10.1186/s10194-026-02322-1","url":null,"abstract":"","PeriodicalId":16013,"journal":{"name":"Journal of Headache and Pain","volume":" ","pages":""},"PeriodicalIF":7.9,"publicationDate":"2026-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12983619/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147433349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-10DOI: 10.1186/s10194-026-02316-z
Kuan-Po Peng, Hauke Basedau, Karl Messlinger, Arne May
{"title":"Anti-CGRP receptor antibodies do not modulate trigeminal pain processing: indication for distinct mechanisms of CGRP pathway blockade.","authors":"Kuan-Po Peng, Hauke Basedau, Karl Messlinger, Arne May","doi":"10.1186/s10194-026-02316-z","DOIUrl":"10.1186/s10194-026-02316-z","url":null,"abstract":"","PeriodicalId":16013,"journal":{"name":"Journal of Headache and Pain","volume":"27 1","pages":""},"PeriodicalIF":7.9,"publicationDate":"2026-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12973897/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147433430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-09DOI: 10.1186/s10194-026-02312-3
Ida Stisen Fogh-Andersen, Jens Christian Hedemann Sørensen, Anja Sofie Petersen, Rigmor Højland Jensen, Kaare Meier
{"title":"Safety and efficacy of occipital nerve stimulation as treatment of chronic cluster headache: an investigator-initiated, double-blind, randomized, placebo-controlled study.","authors":"Ida Stisen Fogh-Andersen, Jens Christian Hedemann Sørensen, Anja Sofie Petersen, Rigmor Højland Jensen, Kaare Meier","doi":"10.1186/s10194-026-02312-3","DOIUrl":"10.1186/s10194-026-02312-3","url":null,"abstract":"","PeriodicalId":16013,"journal":{"name":"Journal of Headache and Pain","volume":" ","pages":""},"PeriodicalIF":7.9,"publicationDate":"2026-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12980930/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147389546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-09DOI: 10.1186/s10194-026-02304-3
Yu Cao, Xin Yang, Peter Svensson, Raymond Wong Chung Wen, Timothy Jie Han Sng, Intekhab Islam, Wei Han, Xingmei Feng, Bozhi Hou, Yuehua Li, Lei Zheng
{"title":"Genetic subtraction reveals divergent pathways and targets in anxiety-related and anxiety-independent TMD.","authors":"Yu Cao, Xin Yang, Peter Svensson, Raymond Wong Chung Wen, Timothy Jie Han Sng, Intekhab Islam, Wei Han, Xingmei Feng, Bozhi Hou, Yuehua Li, Lei Zheng","doi":"10.1186/s10194-026-02304-3","DOIUrl":"https://doi.org/10.1186/s10194-026-02304-3","url":null,"abstract":"","PeriodicalId":16013,"journal":{"name":"Journal of Headache and Pain","volume":" ","pages":""},"PeriodicalIF":7.9,"publicationDate":"2026-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147377601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Chronic migraine (CM) imposes a significant disease burden and frequently co-occurs with medication-overuse headache (MOH). MOH is a secondary headache disorder occurring especially in individuals with primary migraine and associated with excessive analgesic use. Impaired iron homeostasis may be related to the medication overuse behavior, however, its' pathophysiology is complex and incompletely understood. This study examines regional iron deposition in the subcortical nuclei in two comparisons: (1) controls versus chronic migraine patients; and (2) CM patients with medication-overuse headache (wMOH) versus those without MOH (woMOH). Furthermore, it investigates the association between iron deposition and disease outcomes.
Methods: We recruited 38 controls and 72 CM patients (40 wMOH, 32 woMOH). All participants underwent MRI and assessments of migraine duration, analgesic use, and health metrics. CM patients with MOH were further evaluated for one-year relapse rates and Severity of Dependence Scale scores. Quantitative susceptibility mapping (QSM) was used to measure iron content in subcortical regions, and correlations with clinical variables. ROC curve analysis was performed to evaluate the QSM's predictive value for MOH relapse.
Results: CM patients with MOH had lower iron content in the ventral pallidum (VeP, 0.178 ± 0.112 ppm vs. 0.183 ± 0.082 ppm, p < 0.001) compared to those without MOH. Notably, VeP iron content negatively correlated with analgesic excessive use (r = -0.557, p < 0.001) and relapse rates (r = -0.360, p < 0.05). ROC analyses demonstrated significant discriminative capacity for relapse prediction (VeP: AUC = 0.900, 95% CI [0.773-0.999], p < 0.001) in wMOH.
Conclusions: The reduced iron in subcortical nuclei, especially the VeP, relates to analgesic excessive use and relapse in MOH. This insight enhances our understanding of MOH's neurobiological basis and supports the potential development of QSM-based biomarkers for relapse risk prediction.
背景：慢性偏头痛（CM）造成了严重的疾病负担，并经常与药物过度使用头痛（MOH）共同发生。MOH是一种继发性头痛疾病，尤其发生在原发性偏头痛患者中，并与过度使用止痛药有关。铁稳态受损可能与药物过度使用行为有关，但其病理生理机制复杂且不完全清楚。本研究对皮质下核的区域铁沉积进行了两种比较：(1)对照与慢性偏头痛患者；(2) CM患者合并药物过度使用性头痛（wMOH）与不合并药物过度使用性头痛（woMOH）的对比。此外，它还调查了铁沉积与疾病结局之间的关系。方法：我们招募了38例对照组和72例CM患者（wMOH 40例，woMOH 32例）。所有参与者都接受了MRI检查，并评估了偏头痛的持续时间、止痛药的使用和健康指标。CM合并MOH患者进一步评估一年复发率和严重依赖量表评分。定量敏感性制图（QSM）用于测量皮质下区域的铁含量及其与临床变量的相关性。采用ROC曲线分析评价QSM对MOH复发的预测价值。结果：CM合并MOH患者的腹侧白质铁含量较低（VeP, 0.178±0.112 ppm vs. 0.183±0.082 ppm, p）。结论：皮质下核铁含量降低，尤其是VeP，与MOH镇痛药过量使用和复发有关。这一发现增强了我们对MOH神经生物学基础的理解，并支持了基于qsm的复发风险预测生物标志物的潜在开发。
{"title":"Iron concentration in the ventral pallidum of chronic migraine with medication-overuse headache.","authors":"Xiaopei Xu, Jiahui He, Mengting Zhou, Xiao Wu, Fangling Zhao, Jingxin Fu, Xiao Luo, Kaicheng Li, Qingze Zeng, Chao Wang, Xiaojun Guan, Peiyu Huang, Minming Zhang, Kaiming Liu","doi":"10.1186/s10194-026-02321-2","DOIUrl":"https://doi.org/10.1186/s10194-026-02321-2","url":null,"abstract":"<p><strong>Background: </strong>Chronic migraine (CM) imposes a significant disease burden and frequently co-occurs with medication-overuse headache (MOH). MOH is a secondary headache disorder occurring especially in individuals with primary migraine and associated with excessive analgesic use. Impaired iron homeostasis may be related to the medication overuse behavior, however, its' pathophysiology is complex and incompletely understood. This study examines regional iron deposition in the subcortical nuclei in two comparisons: (1) controls versus chronic migraine patients; and (2) CM patients with medication-overuse headache (wMOH) versus those without MOH (woMOH). Furthermore, it investigates the association between iron deposition and disease outcomes.</p><p><strong>Methods: </strong>We recruited 38 controls and 72 CM patients (40 wMOH, 32 woMOH). All participants underwent MRI and assessments of migraine duration, analgesic use, and health metrics. CM patients with MOH were further evaluated for one-year relapse rates and Severity of Dependence Scale scores. Quantitative susceptibility mapping (QSM) was used to measure iron content in subcortical regions, and correlations with clinical variables. ROC curve analysis was performed to evaluate the QSM's predictive value for MOH relapse.</p><p><strong>Results: </strong>CM patients with MOH had lower iron content in the ventral pallidum (VeP, 0.178 ± 0.112 ppm vs. 0.183 ± 0.082 ppm, p < 0.001) compared to those without MOH. Notably, VeP iron content negatively correlated with analgesic excessive use (r = -0.557, p < 0.001) and relapse rates (r = -0.360, p < 0.05). ROC analyses demonstrated significant discriminative capacity for relapse prediction (VeP: AUC = 0.900, 95% CI [0.773-0.999], p < 0.001) in wMOH.</p><p><strong>Conclusions: </strong>The reduced iron in subcortical nuclei, especially the VeP, relates to analgesic excessive use and relapse in MOH. This insight enhances our understanding of MOH's neurobiological basis and supports the potential development of QSM-based biomarkers for relapse risk prediction.</p>","PeriodicalId":16013,"journal":{"name":"Journal of Headache and Pain","volume":" ","pages":""},"PeriodicalIF":7.9,"publicationDate":"2026-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147372423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Epidemiology of primary headache and lifestyle factors among children and adolescents: a regional school-based study in China.","authors":"Guangshuang Lu, Xiaojing Li, Chaofei Bi, Chengqing Niu, Guomao Qin, Wanfeng Wu, Aimin Wang, Yanxun Guo, Shaobo Xiao, Wu Yang, Chuanmei Liu, Ruozhuo Liu","doi":"10.1186/s10194-026-02324-z","DOIUrl":"https://doi.org/10.1186/s10194-026-02324-z","url":null,"abstract":"","PeriodicalId":16013,"journal":{"name":"Journal of Headache and Pain","volume":" ","pages":""},"PeriodicalIF":7.9,"publicationDate":"2026-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147369547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-05DOI: 10.1186/s10194-026-02323-0
Nik Krajnc, Markus Ponleitner, Omar Keritam, Jan Philipp Nolte, Martin Bertich, Nina Müller, Christoph Stapf, Sina Zaic, Stefan Macher, Wolfgang Marik, Klaus Novak, Christian Wöber, Berthold Pemp, Gabriel Bsteh
{"title":"Serum and CSF neurofilament light chain and glial fibrillary acidic protein levels in idiopathic intracranial hypertension.","authors":"Nik Krajnc, Markus Ponleitner, Omar Keritam, Jan Philipp Nolte, Martin Bertich, Nina Müller, Christoph Stapf, Sina Zaic, Stefan Macher, Wolfgang Marik, Klaus Novak, Christian Wöber, Berthold Pemp, Gabriel Bsteh","doi":"10.1186/s10194-026-02323-0","DOIUrl":"https://doi.org/10.1186/s10194-026-02323-0","url":null,"abstract":"","PeriodicalId":16013,"journal":{"name":"Journal of Headache and Pain","volume":" ","pages":""},"PeriodicalIF":7.9,"publicationDate":"2026-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147365444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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