{"title":"Prediction of medication overuse in patients with migraine using cox regression and machine learning: a real-world cohort.","authors":"Teerapong Aramruang, Pawin Numthavaj, Panu Looareesuwan, Thunyarat Anothaisintawee, Patratorn Kunakorntham, Oraluck Pattanaprateep, Charungthai Dejthevaporn, Ammarin Thakkinstian","doi":"10.1186/s10194-026-02269-3","DOIUrl":"https://doi.org/10.1186/s10194-026-02269-3","url":null,"abstract":"","PeriodicalId":16013,"journal":{"name":"Journal of Headache and Pain","volume":" ","pages":""},"PeriodicalIF":7.9,"publicationDate":"2026-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146044223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-24DOI: 10.1186/s10194-025-02263-1
Mona A F Nada, Maiar Ashraf Helmy, Marwa M Zein, Ghada Hatem
{"title":"Medication overuse headache from a tertiary headache center in Egypt: real-world insights.","authors":"Mona A F Nada, Maiar Ashraf Helmy, Marwa M Zein, Ghada Hatem","doi":"10.1186/s10194-025-02263-1","DOIUrl":"10.1186/s10194-025-02263-1","url":null,"abstract":"","PeriodicalId":16013,"journal":{"name":"Journal of Headache and Pain","volume":" ","pages":"30"},"PeriodicalIF":7.9,"publicationDate":"2026-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146044206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-23DOI: 10.1186/s10194-026-02278-2
Veronika K Andersen, Bjarke S Hansen, Emelie Fungbrant, Sara Hestehave, Kristian A Haanes, Karin M L Nordahl
{"title":"Light-aversion and cephalic allodynia in an intravenous CGRP model of migraine-like behaviour in male and female rats.","authors":"Veronika K Andersen, Bjarke S Hansen, Emelie Fungbrant, Sara Hestehave, Kristian A Haanes, Karin M L Nordahl","doi":"10.1186/s10194-026-02278-2","DOIUrl":"https://doi.org/10.1186/s10194-026-02278-2","url":null,"abstract":"","PeriodicalId":16013,"journal":{"name":"Journal of Headache and Pain","volume":" ","pages":""},"PeriodicalIF":7.9,"publicationDate":"2026-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146029749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-23DOI: 10.1186/s10194-025-02252-4
Veronica Munday, Ellie Watson, Diana Y Wei, Alexander D Nesbitt, Peter J Goadsby, Philip R Holland, Ivana Rosenzweig
{"title":"Sleep macro- and microstructure in migraine and cluster headache: a systematic review of objective assessments.","authors":"Veronica Munday, Ellie Watson, Diana Y Wei, Alexander D Nesbitt, Peter J Goadsby, Philip R Holland, Ivana Rosenzweig","doi":"10.1186/s10194-025-02252-4","DOIUrl":"10.1186/s10194-025-02252-4","url":null,"abstract":"","PeriodicalId":16013,"journal":{"name":"Journal of Headache and Pain","volume":" ","pages":"33"},"PeriodicalIF":7.9,"publicationDate":"2026-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12857048/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146040898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-23DOI: 10.1186/s10194-026-02275-5
Emmanouil V Dermitzakis, Andreas A Argyriou, Maria Chondrogianni, Aikaterini Foska, Dimitrios Rikos, Dimitrios Athanasopoulos, Christos Tsironis, Panagiotis Soldatos, Maria Koutsokera, Nikolaos Tsitsaras, Pantelis Litsardopoulos, Eleni Mavraki, Michail Vikelis
{"title":"Eptinezumab to prevent difficult-to-treat migraine: prospective, six-month, real-world multicenter evidence from the GRASP study group.","authors":"Emmanouil V Dermitzakis, Andreas A Argyriou, Maria Chondrogianni, Aikaterini Foska, Dimitrios Rikos, Dimitrios Athanasopoulos, Christos Tsironis, Panagiotis Soldatos, Maria Koutsokera, Nikolaos Tsitsaras, Pantelis Litsardopoulos, Eleni Mavraki, Michail Vikelis","doi":"10.1186/s10194-026-02275-5","DOIUrl":"https://doi.org/10.1186/s10194-026-02275-5","url":null,"abstract":"","PeriodicalId":16013,"journal":{"name":"Journal of Headache and Pain","volume":" ","pages":""},"PeriodicalIF":7.9,"publicationDate":"2026-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146040810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-21DOI: 10.1186/s10194-026-02273-7
Zhen Zhen, Yunze Li, Jie Zhou, Han Li, Andrew Zalesky, Robin Cash, Zhiying Feng, Xianwei Che
{"title":"Prospective open-label trial of personalised connectivity-guided transcranial magnetic stimulation therapy for migraine.","authors":"Zhen Zhen, Yunze Li, Jie Zhou, Han Li, Andrew Zalesky, Robin Cash, Zhiying Feng, Xianwei Che","doi":"10.1186/s10194-026-02273-7","DOIUrl":"https://doi.org/10.1186/s10194-026-02273-7","url":null,"abstract":"","PeriodicalId":16013,"journal":{"name":"Journal of Headache and Pain","volume":" ","pages":""},"PeriodicalIF":7.9,"publicationDate":"2026-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146018531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-20DOI: 10.1186/s10194-026-02274-6
Simone Braca, Gennaro Cretella, Christina Deligianni, Laura Kennelly, Vasilis-Spyridon Tseriotis, Anna P Andreou, Dimos-Dimitrios Mitsikostas, Theodoros Mavridis
{"title":"Noradrenergic system involvement as a major driver of tension-type headache: a systematic review of the current evidence.","authors":"Simone Braca, Gennaro Cretella, Christina Deligianni, Laura Kennelly, Vasilis-Spyridon Tseriotis, Anna P Andreou, Dimos-Dimitrios Mitsikostas, Theodoros Mavridis","doi":"10.1186/s10194-026-02274-6","DOIUrl":"https://doi.org/10.1186/s10194-026-02274-6","url":null,"abstract":"","PeriodicalId":16013,"journal":{"name":"Journal of Headache and Pain","volume":" ","pages":""},"PeriodicalIF":7.9,"publicationDate":"2026-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146010691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-13DOI: 10.1186/s10194-026-02271-9
Marcos Fabio Henriques DosSantos, Lucas Rego Ramos, Lorenzo Bonacchi, Tamires Morett Gama, Ísis Paes d'Assumpção Perez, Romina Nassini, Francesco De Logu
Background: Trigeminal neuralgia, classified as a painful disorder of the trigeminal nerve (PDTN), is characterized by brief, electric shock-like or stabbing pain localized mainly to the maxillary and mandibular regions. The severity of these paroxysmal attacks severely impairs quality of life and, in extreme cases, may lead to suicidal ideation. We hypothesized that PDTN shares a common neuroanatomical signature with other chronic pain disorders, while also exhibiting disorder-specific alterations.
Methods: High-resolution T1-weighted structural MRI scans from 85 individuals diagnosed with painful disorders of the trigeminal nerve (PDTN) and 49,280 control participants from the UK Biobank were analyzed. A non-parametric permutation test (10,000 iterations) randomly reassigned group labels between 85 PDTN cases and 85 individuals reporting no chronic pain or pain-related conditions to generate a null distribution for statistical inference. A second analysis compared the same PDTN group with 85 matched participants reporting chronic pain (excluding orofacial pain), using five covariates and nearest-neighbor matching (1:1 ratio).
Results: Compared to individuals reporting no chronic pain, PDTN patients exhibited significant volumetric reductions in eight amygdala and nineteen thalamic nuclei, as well as eighteen hippocampal subfields. When compared to the chronic pain group, significant differences were restricted to six thalamic nuclei and seven hippocampal subfields.
Conclusions: These findings underscore that PDTN is associated with a distinct neuroanatomical signature, particularly involving subcortical structures such as the thalamus and hippocampus.
{"title":"Subcortical neuroimaging signature of painful disorders of the trigeminal nerve: a UK Biobank study.","authors":"Marcos Fabio Henriques DosSantos, Lucas Rego Ramos, Lorenzo Bonacchi, Tamires Morett Gama, Ísis Paes d'Assumpção Perez, Romina Nassini, Francesco De Logu","doi":"10.1186/s10194-026-02271-9","DOIUrl":"10.1186/s10194-026-02271-9","url":null,"abstract":"<p><strong>Background: </strong>Trigeminal neuralgia, classified as a painful disorder of the trigeminal nerve (PDTN), is characterized by brief, electric shock-like or stabbing pain localized mainly to the maxillary and mandibular regions. The severity of these paroxysmal attacks severely impairs quality of life and, in extreme cases, may lead to suicidal ideation. We hypothesized that PDTN shares a common neuroanatomical signature with other chronic pain disorders, while also exhibiting disorder-specific alterations.</p><p><strong>Methods: </strong>High-resolution T1-weighted structural MRI scans from 85 individuals diagnosed with painful disorders of the trigeminal nerve (PDTN) and 49,280 control participants from the UK Biobank were analyzed. A non-parametric permutation test (10,000 iterations) randomly reassigned group labels between 85 PDTN cases and 85 individuals reporting no chronic pain or pain-related conditions to generate a null distribution for statistical inference. A second analysis compared the same PDTN group with 85 matched participants reporting chronic pain (excluding orofacial pain), using five covariates and nearest-neighbor matching (1:1 ratio).</p><p><strong>Results: </strong>Compared to individuals reporting no chronic pain, PDTN patients exhibited significant volumetric reductions in eight amygdala and nineteen thalamic nuclei, as well as eighteen hippocampal subfields. When compared to the chronic pain group, significant differences were restricted to six thalamic nuclei and seven hippocampal subfields.</p><p><strong>Conclusions: </strong>These findings underscore that PDTN is associated with a distinct neuroanatomical signature, particularly involving subcortical structures such as the thalamus and hippocampus.</p>","PeriodicalId":16013,"journal":{"name":"Journal of Headache and Pain","volume":" ","pages":"40"},"PeriodicalIF":7.9,"publicationDate":"2026-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145959784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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