Pub Date : 2026-02-20DOI: 10.1186/s10194-026-02306-1
Tiantian Chu, Fei Xiong, Feng Gao, Xuebi Tian, Ye Tu
{"title":"Fixel‑based analysis reveals distributed white matter alterations associated with pain severity in trigeminal neuralgia.","authors":"Tiantian Chu, Fei Xiong, Feng Gao, Xuebi Tian, Ye Tu","doi":"10.1186/s10194-026-02306-1","DOIUrl":"https://doi.org/10.1186/s10194-026-02306-1","url":null,"abstract":"","PeriodicalId":16013,"journal":{"name":"Journal of Headache and Pain","volume":" ","pages":""},"PeriodicalIF":7.9,"publicationDate":"2026-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146258462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-20DOI: 10.1186/s10194-026-02299-x
Mira Jaso, Allison M Smith, Henrike Goldstein, Matthias Sehlbrede, Julia Wager
{"title":"Prevalence, medication use, and health care utilization in pediatric primary headache: a school-based cross-sectional study.","authors":"Mira Jaso, Allison M Smith, Henrike Goldstein, Matthias Sehlbrede, Julia Wager","doi":"10.1186/s10194-026-02299-x","DOIUrl":"10.1186/s10194-026-02299-x","url":null,"abstract":"","PeriodicalId":16013,"journal":{"name":"Journal of Headache and Pain","volume":" ","pages":""},"PeriodicalIF":7.9,"publicationDate":"2026-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12930800/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146227048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-19DOI: 10.1186/s10194-026-02266-6
Krisztián Kocsis, Laura Szücs-Bencze, Máté Csomós, Dániel Veréb, Lilla Horváth, Kisa Dominika, Krisztián Attila Szuly, Péter Faragó, Bernadett Tuka, Zsigmond Tamás Kincses, Nikoletta Szabó
{"title":"Subtype-specific enhancement of implicit statistical learning in migraine: insights from BOLD signal variability.","authors":"Krisztián Kocsis, Laura Szücs-Bencze, Máté Csomós, Dániel Veréb, Lilla Horváth, Kisa Dominika, Krisztián Attila Szuly, Péter Faragó, Bernadett Tuka, Zsigmond Tamás Kincses, Nikoletta Szabó","doi":"10.1186/s10194-026-02266-6","DOIUrl":"10.1186/s10194-026-02266-6","url":null,"abstract":"","PeriodicalId":16013,"journal":{"name":"Journal of Headache and Pain","volume":"27 1","pages":"51"},"PeriodicalIF":7.9,"publicationDate":"2026-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12922426/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146227174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-19DOI: 10.1186/s10194-026-02287-1
Emily White Johansson, Ahmed Nabil Shaaban, Mattias Linde, Mathias Mattsson, Lode van der Velde, Sofie Gustafsson, Johan Holm, Christina Dalman, Emilie E Agardh
{"title":"Geographical patterns and determinants of migraine in persons aged ten years or older living in Sweden from 2015 to 2023: a nationwide cross-sectional study.","authors":"Emily White Johansson, Ahmed Nabil Shaaban, Mattias Linde, Mathias Mattsson, Lode van der Velde, Sofie Gustafsson, Johan Holm, Christina Dalman, Emilie E Agardh","doi":"10.1186/s10194-026-02287-1","DOIUrl":"10.1186/s10194-026-02287-1","url":null,"abstract":"","PeriodicalId":16013,"journal":{"name":"Journal of Headache and Pain","volume":"27 1","pages":"50"},"PeriodicalIF":7.9,"publicationDate":"2026-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12918554/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146227194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-18DOI: 10.1186/s10194-026-02294-2
Jr-Wei Wu, Linda Al-Hassany, Matteo Castaldo, Chia-Chun Chiang, Alejandro Labastida-Ramirez, Roberta Messina, Li-Ling Hope Pan, Doga Vuralli, William Wells-Gatnik, Sophie Merve Yener, Eloísa Rubio-Beltrán
{"title":"Premonitory phase in primary headaches: shared and divergent mechanisms in migraine and cluster headache, the Junior Editorial Board Members' vision.","authors":"Jr-Wei Wu, Linda Al-Hassany, Matteo Castaldo, Chia-Chun Chiang, Alejandro Labastida-Ramirez, Roberta Messina, Li-Ling Hope Pan, Doga Vuralli, William Wells-Gatnik, Sophie Merve Yener, Eloísa Rubio-Beltrán","doi":"10.1186/s10194-026-02294-2","DOIUrl":"10.1186/s10194-026-02294-2","url":null,"abstract":"","PeriodicalId":16013,"journal":{"name":"Journal of Headache and Pain","volume":"27 1","pages":"49"},"PeriodicalIF":7.9,"publicationDate":"2026-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12918035/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146220026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-17DOI: 10.1186/s10194-026-02295-1
Wanakorn Rattanawong, Akarin Hiransuthikul, Prakit Anukoolwittaya, Thanakit Pongpitakmetha, Sekh Thanprasertsuk, Nijanth Manohararaj, Wan Aliaa Wan Sulaiman, Gerard Saranza, John Luis Wee, Greg Dayrit, Irma Savitri Madjid, Devi Ariani Sudibyo, Pepi Budianto, Jr-Wei Wu, Appasone Phoumindr, Chananchida Sirilertmekasakul, Surat Tanprawate, Stewart J Tepper
{"title":"Diagnosis challenges and accessibility barriers to migraine management in Southeast Asia: results from the South-East Asia Local breAch on MigraiNe Treatment (SEALANT) study.","authors":"Wanakorn Rattanawong, Akarin Hiransuthikul, Prakit Anukoolwittaya, Thanakit Pongpitakmetha, Sekh Thanprasertsuk, Nijanth Manohararaj, Wan Aliaa Wan Sulaiman, Gerard Saranza, John Luis Wee, Greg Dayrit, Irma Savitri Madjid, Devi Ariani Sudibyo, Pepi Budianto, Jr-Wei Wu, Appasone Phoumindr, Chananchida Sirilertmekasakul, Surat Tanprawate, Stewart J Tepper","doi":"10.1186/s10194-026-02295-1","DOIUrl":"10.1186/s10194-026-02295-1","url":null,"abstract":"","PeriodicalId":16013,"journal":{"name":"Journal of Headache and Pain","volume":" ","pages":"47"},"PeriodicalIF":7.9,"publicationDate":"2026-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12918563/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146213403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-16DOI: 10.1186/s10194-026-02297-z
Mira Pauline Fitzek, Paula Kleist, Cleo Handtmann, Lucas Hendrik Overeem, Carolin Luisa Hoehne, Kristin Sophie Lange, Cornelius Angerhöfer, Yones Salim, Andreas D Ebert, Nicole Mattern, Uwe Reuter, Bianca Raffaelli
Background and objectives: Oxytocin has been implicated in migraine pathophysiology through its roles in pain modulation and vascular regulation. Its receptors are present in migraine-related brain regions and cerebral vessels and interact with key migraine mediators such as calcitonin gene-related peptide (CGRP). Declining oxytocin levels coincide with increased migraine frequency, but a causal role in humans remains unclear. This study examined whether acute oxytocin receptor blockade provokes migraine attacks or alters cerebrovascular function.
Methods: In this randomized, double-blind, placebo-controlled, cross-over study, women with episodic migraine (WM), healthy women (HC), and men with episodic migraine (MM) aged 18-45 years received the oxytocin receptor antagonist atosiban (6.75 mg bolus followed by 54 mg over 3 h) or placebo on two separate visits. Women used continuous hormonal contraception to ensure stable hormone levels. The primary endpoint was the incidence of migraine-like attacks in WM within 12 h post-infusion. Secondary endpoints included the incidence and intensity of any headache and vascular responses.
Results: A total of 20 WM (27.1 ± 5.6 years), 20 HC (25.7 ± 6.8 years) and 20 MM (29.3 ± 6.1 years) completed both provocations visits. During the 12-hour observation period, the incidence of migraine-like attacks in WM did not differ between atosiban and placebo (atosiban: 6 (30%) vs. placebo: 4 (20%; p = 0.75)). Headache of any kind were reported in 15 (75%) vs. 11 (55%) (p = 0.34). HC did not experience migraine-like attacks, though nine (45%) participants reported headache of any kind after atosiban vs. six (30%) after placebo (p = 0.25). Among MM, migraine attacks occurred in two (10%) participants after atosiban vs. three (15%) after placebo (p > 0.999). While HC showed significantly increased temporal artery diameter and middle cerebral artery flow velocity during atosiban administration, no significant vascular changes were observed in participants with migraine.
Discussion: Short-acting oxytocin receptor antagonism did not trigger migraine attacks, suggesting that acute suppression of oxytocin signaling alone is unlikely to trigger migraine under stable hormonal conditions. Instead, oxytocin may act as a modulatory factor within neurovascular networks. Future studies using longer-lasting or brain-penetrant antagonists are needed to further clarify oxytocin's role in migraine susceptibility.
{"title":"Oxytocin receptor antagonism in migraine: a randomized, double-blind, placebo-controlled provocation study.","authors":"Mira Pauline Fitzek, Paula Kleist, Cleo Handtmann, Lucas Hendrik Overeem, Carolin Luisa Hoehne, Kristin Sophie Lange, Cornelius Angerhöfer, Yones Salim, Andreas D Ebert, Nicole Mattern, Uwe Reuter, Bianca Raffaelli","doi":"10.1186/s10194-026-02297-z","DOIUrl":"10.1186/s10194-026-02297-z","url":null,"abstract":"<p><strong>Background and objectives: </strong>Oxytocin has been implicated in migraine pathophysiology through its roles in pain modulation and vascular regulation. Its receptors are present in migraine-related brain regions and cerebral vessels and interact with key migraine mediators such as calcitonin gene-related peptide (CGRP). Declining oxytocin levels coincide with increased migraine frequency, but a causal role in humans remains unclear. This study examined whether acute oxytocin receptor blockade provokes migraine attacks or alters cerebrovascular function.</p><p><strong>Methods: </strong>In this randomized, double-blind, placebo-controlled, cross-over study, women with episodic migraine (WM), healthy women (HC), and men with episodic migraine (MM) aged 18-45 years received the oxytocin receptor antagonist atosiban (6.75 mg bolus followed by 54 mg over 3 h) or placebo on two separate visits. Women used continuous hormonal contraception to ensure stable hormone levels. The primary endpoint was the incidence of migraine-like attacks in WM within 12 h post-infusion. Secondary endpoints included the incidence and intensity of any headache and vascular responses.</p><p><strong>Results: </strong>A total of 20 WM (27.1 ± 5.6 years), 20 HC (25.7 ± 6.8 years) and 20 MM (29.3 ± 6.1 years) completed both provocations visits. During the 12-hour observation period, the incidence of migraine-like attacks in WM did not differ between atosiban and placebo (atosiban: 6 (30%) vs. placebo: 4 (20%; p = 0.75)). Headache of any kind were reported in 15 (75%) vs. 11 (55%) (p = 0.34). HC did not experience migraine-like attacks, though nine (45%) participants reported headache of any kind after atosiban vs. six (30%) after placebo (p = 0.25). Among MM, migraine attacks occurred in two (10%) participants after atosiban vs. three (15%) after placebo (p > 0.999). While HC showed significantly increased temporal artery diameter and middle cerebral artery flow velocity during atosiban administration, no significant vascular changes were observed in participants with migraine.</p><p><strong>Discussion: </strong>Short-acting oxytocin receptor antagonism did not trigger migraine attacks, suggesting that acute suppression of oxytocin signaling alone is unlikely to trigger migraine under stable hormonal conditions. Instead, oxytocin may act as a modulatory factor within neurovascular networks. Future studies using longer-lasting or brain-penetrant antagonists are needed to further clarify oxytocin's role in migraine susceptibility.</p><p><strong>Trial registration information: </strong>DRKS - Deutsches Register Klinischer Studien: DRKS00033341. Registered: 08.01.2024. First patient enrolled: 08.07.2024.</p>","PeriodicalId":16013,"journal":{"name":"Journal of Headache and Pain","volume":" ","pages":""},"PeriodicalIF":7.9,"publicationDate":"2026-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12927216/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146207205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-12DOI: 10.1186/s10194-026-02289-z
Karin Warfvinge, Jacob C A Edvinsson, Aida Maddahi, Lars Edvinsson
{"title":"Hypothalamic and sex-related hormones in migraine.","authors":"Karin Warfvinge, Jacob C A Edvinsson, Aida Maddahi, Lars Edvinsson","doi":"10.1186/s10194-026-02289-z","DOIUrl":"10.1186/s10194-026-02289-z","url":null,"abstract":"","PeriodicalId":16013,"journal":{"name":"Journal of Headache and Pain","volume":" ","pages":""},"PeriodicalIF":7.9,"publicationDate":"2026-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12927229/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146180523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
扫码关注我们
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号