Pub Date : 2026-02-26DOI: 10.1186/s10194-026-02310-5
Kun Wang, Keng Chen, Zundao Shan, Yinxin Zhu, Bo Li, Jingyang Hong, Xinwei Li, Feifang He, Yirong Wang
{"title":"Prediction for occurrence of subdural hematoma following spontaneous intracranial hypotension: a large cohort of 575 adults in a single center from 2023 to 2024.","authors":"Kun Wang, Keng Chen, Zundao Shan, Yinxin Zhu, Bo Li, Jingyang Hong, Xinwei Li, Feifang He, Yirong Wang","doi":"10.1186/s10194-026-02310-5","DOIUrl":"10.1186/s10194-026-02310-5","url":null,"abstract":"","PeriodicalId":16013,"journal":{"name":"Journal of Headache and Pain","volume":" ","pages":""},"PeriodicalIF":7.9,"publicationDate":"2026-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12977453/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147306858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-25DOI: 10.1186/s10194-025-02221-x
Gustavo López-Córdoba, Guadalupe Martínez-Lorenzana, Miguel Condés-Lara, Abimael González-Hernández
{"title":"Electrophysiological evidence about sexual dimorphism in the clonidine-induced inhibition of trigeminal wide dynamic range cell activity.","authors":"Gustavo López-Córdoba, Guadalupe Martínez-Lorenzana, Miguel Condés-Lara, Abimael González-Hernández","doi":"10.1186/s10194-025-02221-x","DOIUrl":"10.1186/s10194-025-02221-x","url":null,"abstract":"","PeriodicalId":16013,"journal":{"name":"Journal of Headache and Pain","volume":"27 1","pages":""},"PeriodicalIF":7.9,"publicationDate":"2026-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12947510/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147306851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-24DOI: 10.1186/s10194-026-02309-y
Srdjan Mavija, Aleksandra Radojičić, Igor Petrušić
{"title":"Triggers, prodrome, aura, and headache interactions in migraine with typical aura: a prospective deep-phenotyping study.","authors":"Srdjan Mavija, Aleksandra Radojičić, Igor Petrušić","doi":"10.1186/s10194-026-02309-y","DOIUrl":"10.1186/s10194-026-02309-y","url":null,"abstract":"","PeriodicalId":16013,"journal":{"name":"Journal of Headache and Pain","volume":"27 1","pages":""},"PeriodicalIF":7.9,"publicationDate":"2026-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12934116/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147284105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-24DOI: 10.1186/s10194-026-02307-0
Irma Savitri Madjid, Fitri Octaviana, Retno Asti Werdhani, Henry Riyanto Sofyan, Ahmad Rafi Faiq, Aditya Putra, Espen Saxhaus Kristoffersen, Jimmy Fransisco Abadinta Barus, Lupi Trilaksono, Ardi Findyartini, Tiara Aninditha, Henrik Winther Schytz
{"title":"Bridging the gap in headache care: a qualitative needs assessment for primary care education in Indonesia.","authors":"Irma Savitri Madjid, Fitri Octaviana, Retno Asti Werdhani, Henry Riyanto Sofyan, Ahmad Rafi Faiq, Aditya Putra, Espen Saxhaus Kristoffersen, Jimmy Fransisco Abadinta Barus, Lupi Trilaksono, Ardi Findyartini, Tiara Aninditha, Henrik Winther Schytz","doi":"10.1186/s10194-026-02307-0","DOIUrl":"https://doi.org/10.1186/s10194-026-02307-0","url":null,"abstract":"","PeriodicalId":16013,"journal":{"name":"Journal of Headache and Pain","volume":" ","pages":""},"PeriodicalIF":7.9,"publicationDate":"2026-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147284071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Local patient-centered headache advocacy with regional and global impact: lessons from the Japanese Patient Advocacy Coalition (JPAC).","authors":"Daisuke Danno, Eriko Yamanaka, Kaori Tabata, Shoji Kikui, Min Kyung Chu, Olivia Begasse de Dhaem, Koichi Hirata, Fumihiko Sakai, Takao Takeshima","doi":"10.1186/s10194-026-02302-5","DOIUrl":"https://doi.org/10.1186/s10194-026-02302-5","url":null,"abstract":"","PeriodicalId":16013,"journal":{"name":"Journal of Headache and Pain","volume":" ","pages":""},"PeriodicalIF":7.9,"publicationDate":"2026-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147276416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-23DOI: 10.1186/s10194-026-02280-8
Emily White Johansson, Mattias Linde, Anna Ohlis, Mathias Mattsson, Ahmed Nabil Shaaban, Sofie Gustafsson, Johan Holm, Christina Dalman, Emilie E Agardh
{"title":"Association of migraine with subsequent risk of depression or anxiety by small-area deprivation: national cohort study with sibling analysis.","authors":"Emily White Johansson, Mattias Linde, Anna Ohlis, Mathias Mattsson, Ahmed Nabil Shaaban, Sofie Gustafsson, Johan Holm, Christina Dalman, Emilie E Agardh","doi":"10.1186/s10194-026-02280-8","DOIUrl":"10.1186/s10194-026-02280-8","url":null,"abstract":"","PeriodicalId":16013,"journal":{"name":"Journal of Headache and Pain","volume":"27 1","pages":""},"PeriodicalIF":7.9,"publicationDate":"2026-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12930664/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147276515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Chronic migraine (CM) involves persistent trigeminal sensitization and synaptic remodeling in the spinal trigeminal nucleus caudalis (SP5C), but the epigenetic mechanisms remain unclear. Kinesin family member 1 A (KIF1A), a synaptic vesicle motor protein, is regulated by transcription factors (TFs) and ten-eleven translocation methylcytosine dioxygenase 1 (TET1), yet its role in CM-related structural synaptic plasticity is unknown.
Methods: TFs potentially regulating KIF1A were predicted using the HOMER and JASPAR databases, identifying specificity protein 1 (SP1) as a candidate regulator. A CM model was induced in male mice by repeated nitroglycerin (NTG) administration. The expression levels of SP1, TET1, KIF1A, and synaptic remodeling-related markers in the SP5C were evaluated using a combination of qPCR, Western blotting, and immunofluorescence. SP1, TET1, and KIF1A were manipulated in vitro/in vivo, and mechanisms were probed by co-immunoprecipitation (Co-IP), dual-luciferase assays, and sequential chromatin immunoprecipitation (Re-ChIP). Synaptic ultrastructure and dendritic morphology were examined by transmission electron microscopy and Golgi-Cox staining.
Results: Repeated NTG increased SP1, TET1, and KIF1A expression in the SP5C, along with synaptic markers. Co-IP/ luciferase reporter and Re-ChIP demonstrated SP1-TET1 cooperation and co-occupancy at the Kif1a promoter, associated with promoter demethylation. Inhibition of SP1 or knockdown of TET1 reduced KIF1A expression and synaptic protein levels, whereas TET1 overexpression in vitro partially mitigated the effects of SP1 inhibition. Notably, KIF1A overexpression both in vitro and in vivo reversed the synaptic impairments induced by SP1 inhibition. Ultrastructural analyses further revealed marked changes in synaptic architecture and dendritic morphology following modulation of this pathway.
Conclusions: CM activates an SP1-TET1 epigenetic regulatory module that demethylates and activates the Kif1a promoter, thereby linking TF-guided DNA demethylation to synaptic remodeling in the SP5C and promoting the structural changes associated with central sensitization. This pathway provides mechanistic insight into the epigenetic regulation of synaptic dysfunction in CM.
{"title":"SP1 recruits TET1 to mediate Kif1a demethylation and synaptic remodeling in a mouse model of chronic migraine.","authors":"Wei Jiang, Peng Yu, Guo-Hua Liang, Wei-Bo Tian, Yi-Fan Li, Meng-Tan Cai, Li-Xi Zhang, Yu Yang, Ming Dong","doi":"10.1186/s10194-026-02296-0","DOIUrl":"https://doi.org/10.1186/s10194-026-02296-0","url":null,"abstract":"<p><strong>Background: </strong>Chronic migraine (CM) involves persistent trigeminal sensitization and synaptic remodeling in the spinal trigeminal nucleus caudalis (SP5C), but the epigenetic mechanisms remain unclear. Kinesin family member 1 A (KIF1A), a synaptic vesicle motor protein, is regulated by transcription factors (TFs) and ten-eleven translocation methylcytosine dioxygenase 1 (TET1), yet its role in CM-related structural synaptic plasticity is unknown.</p><p><strong>Methods: </strong>TFs potentially regulating KIF1A were predicted using the HOMER and JASPAR databases, identifying specificity protein 1 (SP1) as a candidate regulator. A CM model was induced in male mice by repeated nitroglycerin (NTG) administration. The expression levels of SP1, TET1, KIF1A, and synaptic remodeling-related markers in the SP5C were evaluated using a combination of qPCR, Western blotting, and immunofluorescence. SP1, TET1, and KIF1A were manipulated in vitro/in vivo, and mechanisms were probed by co-immunoprecipitation (Co-IP), dual-luciferase assays, and sequential chromatin immunoprecipitation (Re-ChIP). Synaptic ultrastructure and dendritic morphology were examined by transmission electron microscopy and Golgi-Cox staining.</p><p><strong>Results: </strong>Repeated NTG increased SP1, TET1, and KIF1A expression in the SP5C, along with synaptic markers. Co-IP/ luciferase reporter and Re-ChIP demonstrated SP1-TET1 cooperation and co-occupancy at the Kif1a promoter, associated with promoter demethylation. Inhibition of SP1 or knockdown of TET1 reduced KIF1A expression and synaptic protein levels, whereas TET1 overexpression in vitro partially mitigated the effects of SP1 inhibition. Notably, KIF1A overexpression both in vitro and in vivo reversed the synaptic impairments induced by SP1 inhibition. Ultrastructural analyses further revealed marked changes in synaptic architecture and dendritic morphology following modulation of this pathway.</p><p><strong>Conclusions: </strong>CM activates an SP1-TET1 epigenetic regulatory module that demethylates and activates the Kif1a promoter, thereby linking TF-guided DNA demethylation to synaptic remodeling in the SP5C and promoting the structural changes associated with central sensitization. This pathway provides mechanistic insight into the epigenetic regulation of synaptic dysfunction in CM.</p>","PeriodicalId":16013,"journal":{"name":"Journal of Headache and Pain","volume":" ","pages":""},"PeriodicalIF":7.9,"publicationDate":"2026-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146776257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-21DOI: 10.1186/s10194-026-02291-5
Talia Adi, Michael S Gold
{"title":"Meningeal neuropeptide and neuroimmune interactions in the context of migraine.","authors":"Talia Adi, Michael S Gold","doi":"10.1186/s10194-026-02291-5","DOIUrl":"https://doi.org/10.1186/s10194-026-02291-5","url":null,"abstract":"","PeriodicalId":16013,"journal":{"name":"Journal of Headache and Pain","volume":" ","pages":""},"PeriodicalIF":7.9,"publicationDate":"2026-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146776335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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