{"title":"Thiolutin Reverses Lipopolysaccharide/Adenosine Triphosphate-Induced Pyroptosis and Inflammation in Human Gingival Fibroblasts by Suppressing NLRP3 Inflammasome","authors":"Ying Zheng, Shu Jiang","doi":"10.2485/jhtb.32.159","DOIUrl":"https://doi.org/10.2485/jhtb.32.159","url":null,"abstract":"","PeriodicalId":16040,"journal":{"name":"Journal of Hard Tissue Biology","volume":"1 1","pages":""},"PeriodicalIF":0.4,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68967017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Yamada, S. Matsunaga, N. Kasahara, Kei Kitamura, M. Suzuki, Yoshiki Tamiya, Yuki Takeuchi, Akihiro Takahashi, Hitoshi Yamamoto, S. Abe, M. Furusawa
{"title":"The Microscopic Structure of the Root Canal Morphology of the Distobuccal Root of the Maxillary First Molar in Japanese People: A Micro-Computed Tomography Study","authors":"M. Yamada, S. Matsunaga, N. Kasahara, Kei Kitamura, M. Suzuki, Yoshiki Tamiya, Yuki Takeuchi, Akihiro Takahashi, Hitoshi Yamamoto, S. Abe, M. Furusawa","doi":"10.2485/jhtb.32.35","DOIUrl":"https://doi.org/10.2485/jhtb.32.35","url":null,"abstract":"","PeriodicalId":16040,"journal":{"name":"Journal of Hard Tissue Biology","volume":"1 1","pages":""},"PeriodicalIF":0.4,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68967212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The 31st Annual Meeting of the Society for Hard Tissue Regenerative Biology","authors":"","doi":"10.2485/jhtb.32.245","DOIUrl":"https://doi.org/10.2485/jhtb.32.245","url":null,"abstract":"","PeriodicalId":16040,"journal":{"name":"Journal of Hard Tissue Biology","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135313262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
N. Okubo, M. Ishikawa, M. Shakya, Hidetaka Hosono, Osamu Maehara, Tatsuya Ohkawara, S. Ohnishi, T. Akazawa, M. Murata
: Onlay bone augmentation is a challenging field, especially in esthetic zones. In implant dentistry, labial bone loss is generally recovered through autologous bone and/or biomaterials. Dental pioneers have been applying a patient-own demineralized dentin matrix (DDM) for bone regeneration. The aim of this study was to histologically and radiologically evaluate horizontal bone augmentation on an anterior atrophic maxilla using an autograft of non-vital tooth-derived DDM for implant. A 56-year-old female patient presented with severe labial bone loss. Autologous DDM was immediately pre pared for horizontal ridge augmentation. DDM blocks were fixed with titanium screws for lateral augmentation. DDM gran ules were grafted on the atrophic bone between the DDM blocks. Twelve months postoperatively, bone biopsy was per formed from the implant placement point for histological observation. X-ray computed tomography (CT) was performed before and after the DDM graft surgery. Hematoxylin and eosin sections showed that new bones were directly generated on the DDM residue. CT images showed the original buccal bone lines and root-type and wall-type DDM. The grafted DDMs were clearly found on the original bone. The outlines in the 22nd region indicated an 8.11 mm horizontal width after the implant placements compared to 4.95 mm before the augmentation. Additionally, the width at the upper level increased from 3.38 mm to 5.92 mm. DDM scaffolds contributed to the horizontal bony support required to place the implants. The patient experienced therapeutic success with DDM immediate autograft and implant surgery.
{"title":"Autograft of Demineralized Dentin Matrix Prepared Immediately after Extraction for Horizontal Bone Augmentation of the Anterior Atrophic Maxilla: A First Case of Non-Vital Tooth-Derived Dentin","authors":"N. Okubo, M. Ishikawa, M. Shakya, Hidetaka Hosono, Osamu Maehara, Tatsuya Ohkawara, S. Ohnishi, T. Akazawa, M. Murata","doi":"10.2485/jhtb.31.47","DOIUrl":"https://doi.org/10.2485/jhtb.31.47","url":null,"abstract":": Onlay bone augmentation is a challenging field, especially in esthetic zones. In implant dentistry, labial bone loss is generally recovered through autologous bone and/or biomaterials. Dental pioneers have been applying a patient-own demineralized dentin matrix (DDM) for bone regeneration. The aim of this study was to histologically and radiologically evaluate horizontal bone augmentation on an anterior atrophic maxilla using an autograft of non-vital tooth-derived DDM for implant. A 56-year-old female patient presented with severe labial bone loss. Autologous DDM was immediately pre pared for horizontal ridge augmentation. DDM blocks were fixed with titanium screws for lateral augmentation. DDM gran ules were grafted on the atrophic bone between the DDM blocks. Twelve months postoperatively, bone biopsy was per formed from the implant placement point for histological observation. X-ray computed tomography (CT) was performed before and after the DDM graft surgery. Hematoxylin and eosin sections showed that new bones were directly generated on the DDM residue. CT images showed the original buccal bone lines and root-type and wall-type DDM. The grafted DDMs were clearly found on the original bone. The outlines in the 22nd region indicated an 8.11 mm horizontal width after the implant placements compared to 4.95 mm before the augmentation. Additionally, the width at the upper level increased from 3.38 mm to 5.92 mm. DDM scaffolds contributed to the horizontal bony support required to place the implants. The patient experienced therapeutic success with DDM immediate autograft and implant surgery.","PeriodicalId":16040,"journal":{"name":"Journal of Hard Tissue Biology","volume":"1 1","pages":""},"PeriodicalIF":0.4,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68966469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
: The dental panoramic radiographs (PR) and lateral cephalographs (LC) of 140 subjects in the age group between 5 and 24 years were examined to evaluate the mandibular morphology in relation to gender and age. The examined films were divided into seven age groups. The bigonial width (BW), mandibular body height (MBH) and length (MBL), mandibular ramus width (MRW), height (MRH) and length (MRL), and gonial angle were recorded, measured and the data analyz-ed. Level of significance was set at 0.05. In our study the mean value of BW and MRW increased in both gender with in creasing age up to age 17 years, then began decreasing. The anterior and posterior MBH and MBL increased with increasing age for both genders with statistically significant differences between the first and second groups ( p < 0.05) and the fourth and fifth groups ( p < 0.05) for anterior MBH, and between the third and fourth groups ( p < 0.05) for posterior MBH and MBL ( p < 0.05). MRH and MRL also increased with increasing age with statistically significant differences between the third and fourth ( p < 0.05) and the fourth and fifth ( p < 0.05) age groups for MRH and the fourth and fifth ( p < 0.05) and fifth and sixth ( p < 0.05) age groups for MRL. On the other hand, the gonial angle decreased with increasing age but without significant differences. Knowledge of mandibular growth is important factors for diagnosis and treatment planning in ortho dontics as well as community medicine for monitoring the growth of children.
{"title":"Gender and Age Differences in Mandibular Ramus and Body Measurements: A Radiographic Study","authors":"A. Fekonja, A. Čretnik","doi":"10.2485/jhtb.31.9","DOIUrl":"https://doi.org/10.2485/jhtb.31.9","url":null,"abstract":": The dental panoramic radiographs (PR) and lateral cephalographs (LC) of 140 subjects in the age group between 5 and 24 years were examined to evaluate the mandibular morphology in relation to gender and age. The examined films were divided into seven age groups. The bigonial width (BW), mandibular body height (MBH) and length (MBL), mandibular ramus width (MRW), height (MRH) and length (MRL), and gonial angle were recorded, measured and the data analyz-ed. Level of significance was set at 0.05. In our study the mean value of BW and MRW increased in both gender with in creasing age up to age 17 years, then began decreasing. The anterior and posterior MBH and MBL increased with increasing age for both genders with statistically significant differences between the first and second groups ( p < 0.05) and the fourth and fifth groups ( p < 0.05) for anterior MBH, and between the third and fourth groups ( p < 0.05) for posterior MBH and MBL ( p < 0.05). MRH and MRL also increased with increasing age with statistically significant differences between the third and fourth ( p < 0.05) and the fourth and fifth ( p < 0.05) age groups for MRH and the fourth and fifth ( p < 0.05) and fifth and sixth ( p < 0.05) age groups for MRL. On the other hand, the gonial angle decreased with increasing age but without significant differences. Knowledge of mandibular growth is important factors for diagnosis and treatment planning in ortho dontics as well as community medicine for monitoring the growth of children.","PeriodicalId":16040,"journal":{"name":"Journal of Hard Tissue Biology","volume":"1 1","pages":""},"PeriodicalIF":0.4,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68966532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"USP22 Mediates High Glucose-Induced Injury and Epithelial-Mesenchymal Transition in Podocytes via Regulating the RIPK3/MLKL Signaling Pathway","authors":"Renhua Liu, Weifeng Zhang, J. Cai, Weiping Lin, Qingfa Zheng, Yong Wu","doi":"10.2485/jhtb.31.187","DOIUrl":"https://doi.org/10.2485/jhtb.31.187","url":null,"abstract":"","PeriodicalId":16040,"journal":{"name":"Journal of Hard Tissue Biology","volume":"1 1","pages":""},"PeriodicalIF":0.4,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68966632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Wenyin Zhu, Wenrui Dong, Shuangshuang Zhang, Yi Shuai
{"title":"Alterations between Autophagy and Apoptosis in Alveolar Bone Mesenchymal Stem Cells under Orthodontic Force and Their Effects on Osteogenesis","authors":"Wenyin Zhu, Wenrui Dong, Shuangshuang Zhang, Yi Shuai","doi":"10.2485/jhtb.31.147","DOIUrl":"https://doi.org/10.2485/jhtb.31.147","url":null,"abstract":"","PeriodicalId":16040,"journal":{"name":"Journal of Hard Tissue Biology","volume":"1 1","pages":""},"PeriodicalIF":0.4,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68966051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"microRNA 21 Promotes the Proliferation and Metastasis of Oral Squamous Cell Carcinoma by Targeting RECK","authors":"Shun T Sun, Shanshan Zhao, Hongyu Yang, Feng Wang","doi":"10.2485/jhtb.31.257","DOIUrl":"https://doi.org/10.2485/jhtb.31.257","url":null,"abstract":"","PeriodicalId":16040,"journal":{"name":"Journal of Hard Tissue Biology","volume":"1 1","pages":""},"PeriodicalIF":0.4,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68966420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Keisuke Matsumoto, T. Mano, Kazuya Inoue, Kayoko Yamamoto, Naoko Imagawa, Ayaka Takahashi, T. Ueno
: Vascularized autologous bone grafts are widely used for mandibular reconstruction. There have also been numerous reports of occlusal reconstruction by placement of implants in the grafted bone following reconstruction of the mandible. However, the histological structure of the bone used for the graft is different from that of healthy mandibular bone, and the osseointegration process of implants placed in grafted bone is not clear. In this study, implants placed in reconstructions using grafted bone were assessed by measuring the implant stability quotient (ISQ), and their values were compared to those from implants in healthy mandibular bone. The subjects were 5 implants placed in the sites of mandibular reconstructions with vascularized fibula flaps. The controls were 54 implants placed in the molar region of healthy mandibles. All im plant placements were carried out by a two-stage procedure, and the ISQs were measured at first-stage surgery and at sec -ond-stage surgery. The ISQ values thus obtained and the change in ISQ from first-stage surgery to second-stage surgery were examined statistically. There was no significant difference in the ISQ between the two groups at first-stage surgery, but the values of the ISQ and the change in ISQ were significantly greater in the mandibular reconstruction at second-stage sur gery. This appears to be the result of histological differences between the reconstruction site and the healthy bone. The ISQ is an objective index of osseointegration of the implant. The present results suggest that observing changes in ISQ over time allows investigation of the usefulness of different types of bone grafts for implant therapy.
{"title":"Investigation of Implant Stability Quotient Values of Dental Implants Placed in Vascularized Bone Grafts","authors":"Keisuke Matsumoto, T. Mano, Kazuya Inoue, Kayoko Yamamoto, Naoko Imagawa, Ayaka Takahashi, T. Ueno","doi":"10.2485/jhtb.31.55","DOIUrl":"https://doi.org/10.2485/jhtb.31.55","url":null,"abstract":": Vascularized autologous bone grafts are widely used for mandibular reconstruction. There have also been numerous reports of occlusal reconstruction by placement of implants in the grafted bone following reconstruction of the mandible. However, the histological structure of the bone used for the graft is different from that of healthy mandibular bone, and the osseointegration process of implants placed in grafted bone is not clear. In this study, implants placed in reconstructions using grafted bone were assessed by measuring the implant stability quotient (ISQ), and their values were compared to those from implants in healthy mandibular bone. The subjects were 5 implants placed in the sites of mandibular reconstructions with vascularized fibula flaps. The controls were 54 implants placed in the molar region of healthy mandibles. All im plant placements were carried out by a two-stage procedure, and the ISQs were measured at first-stage surgery and at sec -ond-stage surgery. The ISQ values thus obtained and the change in ISQ from first-stage surgery to second-stage surgery were examined statistically. There was no significant difference in the ISQ between the two groups at first-stage surgery, but the values of the ISQ and the change in ISQ were significantly greater in the mandibular reconstruction at second-stage sur gery. This appears to be the result of histological differences between the reconstruction site and the healthy bone. The ISQ is an objective index of osseointegration of the implant. The present results suggest that observing changes in ISQ over time allows investigation of the usefulness of different types of bone grafts for implant therapy.","PeriodicalId":16040,"journal":{"name":"Journal of Hard Tissue Biology","volume":"1 1","pages":""},"PeriodicalIF":0.4,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68966475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yusuke Oomura, S. Matsunaga, M. Okamura, Taiki Suzuki, N. Kasahara, S. Abe, Takeshi Nomura
: The objective of this study was to determine the effect of zoledronic acid on mandibular bone quality in osteo porotic model mice. Zoledronic acid was administered to ovariectomized mice, and mandibular bone was harvested. Pol ished specimens were prepared, and the biological apatite (BAp) crystal alignment and changes in collagen fiber bundles in the alveolar and basal regions of the mandible were analyzed. It was found that ovariectomy increased BAp crystal align -ment. The administration of zoledronic acid post-ovariectomy normalized BAp crystal alignment in the basal region of the mandible. However, BAp crystal alignment in the alveolar region decreased significantly. Ovariectomy decreased the diam eters of collagen fiber bundles in both the alveolar and basal regions and significantly increased their lengths. The adminis tration of zoledronic acid post-ovariectomy decreased both the diameters and lengths of collagen fiber bundles. These re sults showed that the microarchitecture of the mandibular bone changes to compensate for osteoporosis-induced loss of bone mass and adapts to the load environment resulting from mastication. Interestingly, they suggested that zoledronic acid severely reduces the bone quality of osteoporotic alveolar bone in a site-specific manner.
{"title":"Effect of Zoledronic Acid on Bone Structure of the Mandible in Ovariectomized Mice","authors":"Yusuke Oomura, S. Matsunaga, M. Okamura, Taiki Suzuki, N. Kasahara, S. Abe, Takeshi Nomura","doi":"10.2485/jhtb.31.207","DOIUrl":"https://doi.org/10.2485/jhtb.31.207","url":null,"abstract":": The objective of this study was to determine the effect of zoledronic acid on mandibular bone quality in osteo porotic model mice. Zoledronic acid was administered to ovariectomized mice, and mandibular bone was harvested. Pol ished specimens were prepared, and the biological apatite (BAp) crystal alignment and changes in collagen fiber bundles in the alveolar and basal regions of the mandible were analyzed. It was found that ovariectomy increased BAp crystal align -ment. The administration of zoledronic acid post-ovariectomy normalized BAp crystal alignment in the basal region of the mandible. However, BAp crystal alignment in the alveolar region decreased significantly. Ovariectomy decreased the diam eters of collagen fiber bundles in both the alveolar and basal regions and significantly increased their lengths. The adminis tration of zoledronic acid post-ovariectomy decreased both the diameters and lengths of collagen fiber bundles. These re sults showed that the microarchitecture of the mandibular bone changes to compensate for osteoporosis-induced loss of bone mass and adapts to the load environment resulting from mastication. Interestingly, they suggested that zoledronic acid severely reduces the bone quality of osteoporotic alveolar bone in a site-specific manner.","PeriodicalId":16040,"journal":{"name":"Journal of Hard Tissue Biology","volume":"1 1","pages":""},"PeriodicalIF":0.4,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68966275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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