Sanaz Najafi, A. Davoodabadi, S. Kazemi, M. Ghasempour
{"title":"Antibacterial Effect of Arginine, Protamine, Aqueous Extracts of Green Tea, and Aloe Vera against Escherichia Coli","authors":"Sanaz Najafi, A. Davoodabadi, S. Kazemi, M. Ghasempour","doi":"10.52547/sjimu.30.4.56","DOIUrl":"https://doi.org/10.52547/sjimu.30.4.56","url":null,"abstract":"","PeriodicalId":16041,"journal":{"name":"journal of ilam university of medical sciences","volume":"114 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77702706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Marziyeh Choupani, A. Alihosseini, M. Monajjemi, Hossein Sakhaeinia
Ni atoms increases the electron charge density. The energy gap of genistein-graphene doped with Ni atoms indicates reactivity and high electron charge density of this compound and can be used as a suitable option to increase the uptake efficiency of the genistein drug molecule.
{"title":"Theoretical Study of Adsorption of Genistein on Graphene and Graphene Doped with Metal Atoms (Ni, Ti, Cr, Se)","authors":"Marziyeh Choupani, A. Alihosseini, M. Monajjemi, Hossein Sakhaeinia","doi":"10.52547/sjimu.30.4.94","DOIUrl":"https://doi.org/10.52547/sjimu.30.4.94","url":null,"abstract":"Ni atoms increases the electron charge density. The energy gap of genistein-graphene doped with Ni atoms indicates reactivity and high electron charge density of this compound and can be used as a suitable option to increase the uptake efficiency of the genistein drug molecule.","PeriodicalId":16041,"journal":{"name":"journal of ilam university of medical sciences","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83992576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mehdi Shabani, Saeed Saffarian Hamedani, Reza Usefi saeedabadi
of university independence, leadership independence had the most impact with R2=0.942 and path coefficient=0.971. Discussion & Conclusion: Based on the path coefficients, a factor load of 0.644 was established between the two variables of policy-making and university autonomy which was above average and, therefore, significant. Moreover, since the t-statistic value of 16.247 was established out of the (-2.58, 2.58) range, it can be concluded that the relationship between policy-making and university autonomy in macro medical universities in region 3 was positive and meaningful.
{"title":"Impact of Policy-Making on the University Autonomy in Macro Medical Universities of Region Three","authors":"Mehdi Shabani, Saeed Saffarian Hamedani, Reza Usefi saeedabadi","doi":"10.52547/sjimu.30.4.27","DOIUrl":"https://doi.org/10.52547/sjimu.30.4.27","url":null,"abstract":"of university independence, leadership independence had the most impact with R2=0.942 and path coefficient=0.971. Discussion & Conclusion: Based on the path coefficients, a factor load of 0.644 was established between the two variables of policy-making and university autonomy which was above average and, therefore, significant. Moreover, since the t-statistic value of 16.247 was established out of the (-2.58, 2.58) range, it can be concluded that the relationship between policy-making and university autonomy in macro medical universities in region 3 was positive and meaningful.","PeriodicalId":16041,"journal":{"name":"journal of ilam university of medical sciences","volume":"28 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88359023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The results of repeated measures analysis of variance the effectiveness of Benson’s relaxation exercises on perceived stress, anxiety, and resilience as well as the effectiveness of emotion regulation training based on the Gross model on perceived stress and anxiety in patients. The comparison of the two treatment models showed that Benson’s relaxation exercises could reduce patients’ perceived stress and anxiety more effectively. However, emotion regulation training based on the Gross model has been more effective in increasing patients’ resilience than Benson’s relaxation exercises. the model and muscle relaxation exercises can be used as an effective intervention to complement medical treatment and improve patients' general health.
{"title":"Comparison of the Effectiveness of Emotion Regulation Method Based on Gross Model and Muscle Relaxation Technique on Perceived Stress, Anxiety, and Resilience in Patients with Coronary Heart Disease","authors":"Rahmat Ramazani, Fatemeh Mohammadi shir mahleh, Tahreh Ranjbaripour, Vahid Ahamdi, Javid Peymani","doi":"10.52547/sjimu.30.4.1","DOIUrl":"https://doi.org/10.52547/sjimu.30.4.1","url":null,"abstract":"The results of repeated measures analysis of variance the effectiveness of Benson’s relaxation exercises on perceived stress, anxiety, and resilience as well as the effectiveness of emotion regulation training based on the Gross model on perceived stress and anxiety in patients. The comparison of the two treatment models showed that Benson’s relaxation exercises could reduce patients’ perceived stress and anxiety more effectively. However, emotion regulation training based on the Gross model has been more effective in increasing patients’ resilience than Benson’s relaxation exercises. the model and muscle relaxation exercises can be used as an effective intervention to complement medical treatment and improve patients' general health.","PeriodicalId":16041,"journal":{"name":"journal of ilam university of medical sciences","volume":"28 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73779236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Methods: This study was conducted on 240 blood samples (1 each) from women in four groups: polycystic, diabetes, polycystic-diabetes, and control. Genomic DNA extraction was performed using the extraction kit, according to the protocol. A primer pair was designed and synthesized for the exon 1 sequence of the NOEY2 gene. After gene amplification by polymerase chain reaction (PCR) and evaluation of band quality, Sanger sequencing was performed on PCR products. Sequencing results were analyzed using Chromas, GeneRunner, and Alignment software, and statistical calculations were performed by SNPAlyze, SPSS, and Web-Assotest program. two and of nucleotides and in the region of a between affect the affinity to bind in certain transcription factors by allelic changes due to its location in the CTCF overlapping promoter region.
{"title":"Association of Exon 1 Variants of NOEY2 Gene with Poly cystic Ovary Syndrome (PCOS) and Diabetes","authors":"Parichehr Karajibani, Abolhasan Rezaei","doi":"10.52547/sjimu.30.4.106","DOIUrl":"https://doi.org/10.52547/sjimu.30.4.106","url":null,"abstract":"Methods: This study was conducted on 240 blood samples (1 each) from women in four groups: polycystic, diabetes, polycystic-diabetes, and control. Genomic DNA extraction was performed using the extraction kit, according to the protocol. A primer pair was designed and synthesized for the exon 1 sequence of the NOEY2 gene. After gene amplification by polymerase chain reaction (PCR) and evaluation of band quality, Sanger sequencing was performed on PCR products. Sequencing results were analyzed using Chromas, GeneRunner, and Alignment software, and statistical calculations were performed by SNPAlyze, SPSS, and Web-Assotest program. two and of nucleotides and in the region of a between affect the affinity to bind in certain transcription factors by allelic changes due to its location in the CTCF overlapping promoter region.","PeriodicalId":16041,"journal":{"name":"journal of ilam university of medical sciences","volume":"70 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77396360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Z. Tootian, S. Fazelipour, M. Sheibani, Hossien Erik-Aghaji, Reyhaneh Hooshmand Abbasi
the necessary and the histomorphometric examination was conducted using an optical microscope equipped with Axiovision The thickness of mucosa, submucosa, musculature, and depth of pits was measured and the frequency of parietal cells was calculated in the dimensions of × code: 7506001/6/7) Findings: Histological results indicated destruction and disruption of the mucosal epithelium and gastric pits and atrophy of gastric glands including glandular cells. In the histomorphometric examination of the non-glandular part, only the thickness of the mucosa had a significant difference in the group receiving the highest dose of aspartame compared to the control group (P<0.05). However, in the evaluation of the glandular part, mucosal and muscle thickness in all three experimental groups and the submucosa thickness in the glandular and non-glandular parts in the experimental group (400 mg body weight) showed a significant increase compared to the control group (P<0.05). Moreover, the depth of gastric pits increased significantly and the frequency of parietal cells had a significant decrease in the experimental groups compared to the control group (P<0.05). Discussion & Conclusion: Although aspartame may partially play a protective role by decreasing parietal cells, it should be noted that higher doses of aspartame could induce tissue changes in different layers of the stomach. Therefore, it is recommended to use it with more caution.
{"title":"Effect of Aspartame on Histology and Histomorphometry of Stomach in Balb/C Mice","authors":"Z. Tootian, S. Fazelipour, M. Sheibani, Hossien Erik-Aghaji, Reyhaneh Hooshmand Abbasi","doi":"10.52547/sjimu.30.4.39","DOIUrl":"https://doi.org/10.52547/sjimu.30.4.39","url":null,"abstract":"the necessary and the histomorphometric examination was conducted using an optical microscope equipped with Axiovision The thickness of mucosa, submucosa, musculature, and depth of pits was measured and the frequency of parietal cells was calculated in the dimensions of × code: 7506001/6/7) Findings: Histological results indicated destruction and disruption of the mucosal epithelium and gastric pits and atrophy of gastric glands including glandular cells. In the histomorphometric examination of the non-glandular part, only the thickness of the mucosa had a significant difference in the group receiving the highest dose of aspartame compared to the control group (P<0.05). However, in the evaluation of the glandular part, mucosal and muscle thickness in all three experimental groups and the submucosa thickness in the glandular and non-glandular parts in the experimental group (400 mg body weight) showed a significant increase compared to the control group (P<0.05). Moreover, the depth of gastric pits increased significantly and the frequency of parietal cells had a significant decrease in the experimental groups compared to the control group (P<0.05). Discussion & Conclusion: Although aspartame may partially play a protective role by decreasing parietal cells, it should be noted that higher doses of aspartame could induce tissue changes in different layers of the stomach. Therefore, it is recommended to use it with more caution.","PeriodicalId":16041,"journal":{"name":"journal of ilam university of medical sciences","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89529193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
expression (P=0.038). Discussion & Conclusion: The results indicate that crocin stimulates the apoptotic cells in MCF7 breast cancer cells and can be used as a new therapeutic strategy for the treatment of breast cancer. Study (Saffron Component) on Apoptosis or Survival of MCF7 Breast Cancer Cells Lines) PTEN/AKT1 Signaling 2022;30(4): 47-55.
{"title":"Study of Crocin (Saffron Component) on Apoptosis or Survival of MCF7 Breast Cancer Cells Lines) PTEN/AKT1 signaling pathway)","authors":"S. Ghorbian, Aysan Hajizadeh","doi":"10.52547/sjimu.30.4.47","DOIUrl":"https://doi.org/10.52547/sjimu.30.4.47","url":null,"abstract":"expression (P=0.038). Discussion & Conclusion: The results indicate that crocin stimulates the apoptotic cells in MCF7 breast cancer cells and can be used as a new therapeutic strategy for the treatment of breast cancer. Study (Saffron Component) on Apoptosis or Survival of MCF7 Breast Cancer Cells Lines) PTEN/AKT1 Signaling 2022;30(4): 47-55.","PeriodicalId":16041,"journal":{"name":"journal of ilam university of medical sciences","volume":"39 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86541049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: During exercise, angiogenesis occurs in active skeletal muscle; however, little is known about potential mechanisms for improving this adaptation. This study aimed to investigate a period of interval training on chemokine gene expression and its effect on vascular endothelial growth factors in male adult rats. Material & Methods: In this study , 24 rats were divided into three groups (n=8 in each): high-intensity training (HIT), low-intensity training (LIT), and control groups. HIT and LIT groups were trained for eight weeks (five days per week). The exercise program in the HIT group consisted of running on a treadmill for 8 min with 85-90% VO2max intensity and 2 min with 50-60% VO2max intensity. The LIT group exercise program consisted of running on a treadmill for 8 min with 55-60% VO2max intensity and 2 min with 45-50% VO2max intensity. The control group had no training. The expression of chemokine and vascular endothelial growth factor genes was measured in soleus muscle . The data were analyzed using one-way ANOVA and Tukey post hoc test. Statistical differences were considered significant at P<0.05. (Ethic code: 141/370299) Findings: The results of this study, showed that the expression levels of chemokine and vascular endothelial growth factor gene in the HIT group were significantly higher than that in the control group (P=0.01, P=0.04), while the levels of chemokine and vascular endothelial growth factor in the LIT group were not significantly different from those in the control group (P=0.2, P=0.1). Discussion & Conclusion: According to the results of the present study, it seems that high-intensity exercises can be more effective than low-intensity exercises in increasing angiogenesis caused by the increase of chemokine that in turn depends on vascular endothelial growth factor levels.
{"title":"Effect of Eight Weeks of High-Intensity and Low-Intensity Interval Training on Chemokine Gene Expression and Vascular Endothelial Growth Factor in Male Adult Rats","authors":"E. Vosadi, F. Gholami, Marzieh Amirsalary","doi":"10.52547/sjimu.30.4.86","DOIUrl":"https://doi.org/10.52547/sjimu.30.4.86","url":null,"abstract":"Introduction: During exercise, angiogenesis occurs in active skeletal muscle; however, little is known about potential mechanisms for improving this adaptation. This study aimed to investigate a period of interval training on chemokine gene expression and its effect on vascular endothelial growth factors in male adult rats. Material & Methods: In this study , 24 rats were divided into three groups (n=8 in each): high-intensity training (HIT), low-intensity training (LIT), and control groups. HIT and LIT groups were trained for eight weeks (five days per week). The exercise program in the HIT group consisted of running on a treadmill for 8 min with 85-90% VO2max intensity and 2 min with 50-60% VO2max intensity. The LIT group exercise program consisted of running on a treadmill for 8 min with 55-60% VO2max intensity and 2 min with 45-50% VO2max intensity. The control group had no training. The expression of chemokine and vascular endothelial growth factor genes was measured in soleus muscle . The data were analyzed using one-way ANOVA and Tukey post hoc test. Statistical differences were considered significant at P<0.05. (Ethic code: 141/370299) Findings: The results of this study, showed that the expression levels of chemokine and vascular endothelial growth factor gene in the HIT group were significantly higher than that in the control group (P=0.01, P=0.04), while the levels of chemokine and vascular endothelial growth factor in the LIT group were not significantly different from those in the control group (P=0.2, P=0.1). Discussion & Conclusion: According to the results of the present study, it seems that high-intensity exercises can be more effective than low-intensity exercises in increasing angiogenesis caused by the increase of chemokine that in turn depends on vascular endothelial growth factor levels.","PeriodicalId":16041,"journal":{"name":"journal of ilam university of medical sciences","volume":"26 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84393837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
had more effective inhibition than standard chemical drugs due to their suitable placement in the active site of the main protease enzyme of COVID-19 and can be good candidates for in vitro and in vivo studies.
{"title":"Efficacy Evaluation of Quercetin and Its Analogues on the Main Protease Enzyme of the COVID-19 Using Molecular Docking Studies","authors":"Tooba Abdizadeh","doi":"10.52547/sjimu.30.4.66","DOIUrl":"https://doi.org/10.52547/sjimu.30.4.66","url":null,"abstract":"had more effective inhibition than standard chemical drugs due to their suitable placement in the active site of the main protease enzyme of COVID-19 and can be good candidates for in vitro and in vivo studies.","PeriodicalId":16041,"journal":{"name":"journal of ilam university of medical sciences","volume":"43 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91355803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mohamad ahim Forouzeh, Abolfazl Sharifian, H. Yeganeh, H. Shahiri tabarestani
the Asteraceae medicinal properties, its essential for the treatment of dry coughs and of the mouth, throat, and respiratory tract. This study aimed to assess some phytochemical characteristics of Tussilago farfara L. and compare changes in this plant at different altitudes. Material & Methods: To investigate the changes in the amount of the effective substance of the studied plant in the altitude gradient, altitude classes of 1100-2600 meters were considered in Golestan province, Iran, considering the presence and abundance of the species. In each phenological stage (before and after flowering time), plant samples were randomly collected in each altitude class and transferred to the laboratory. Total phenol content and flavonoid content were measured using the Folin-Ciocalteu and aluminum chloride methods, respectively. The antioxidant activity of the methanolic extract was also evaluated using the DPPH (2,2-Diphenyl-1-picrylhydrazyl) reagent. Findings: The results showed that the highest amounts of total phenol content, flavonoids, and antioxidant activity were observed at altitudes above 2200 meters, and there was a significant difference in plants (Tussilago farfara L.) grown in different altitudes in terms of phytochemical properties. Based on the comparison of phytochemical properties of this plant in different phenological stages, the highest content of total phenol and flavonoids were observed in the phonological stage of flowering and the highest (42.08%) antioxidant activity of leaves was observed in the vegetative stage. Discussion & Conclusion: The results of this study can help activists in the field of medicinal plants to determine the appropriate height range and phenological stage in harvesting the leaves of this plant to achieve the highest levels of phenol content, antioxidant activity.
{"title":"Evaluation of Antioxidant Activity, Phenolic, and Flavonoid Content of Tussilago farfara L. in Different Altitudes and Phenological Stages","authors":"Mohamad ahim Forouzeh, Abolfazl Sharifian, H. Yeganeh, H. Shahiri tabarestani","doi":"10.52547/sjimu.30.4.15","DOIUrl":"https://doi.org/10.52547/sjimu.30.4.15","url":null,"abstract":"the Asteraceae medicinal properties, its essential for the treatment of dry coughs and of the mouth, throat, and respiratory tract. This study aimed to assess some phytochemical characteristics of Tussilago farfara L. and compare changes in this plant at different altitudes. Material & Methods: To investigate the changes in the amount of the effective substance of the studied plant in the altitude gradient, altitude classes of 1100-2600 meters were considered in Golestan province, Iran, considering the presence and abundance of the species. In each phenological stage (before and after flowering time), plant samples were randomly collected in each altitude class and transferred to the laboratory. Total phenol content and flavonoid content were measured using the Folin-Ciocalteu and aluminum chloride methods, respectively. The antioxidant activity of the methanolic extract was also evaluated using the DPPH (2,2-Diphenyl-1-picrylhydrazyl) reagent. Findings: The results showed that the highest amounts of total phenol content, flavonoids, and antioxidant activity were observed at altitudes above 2200 meters, and there was a significant difference in plants (Tussilago farfara L.) grown in different altitudes in terms of phytochemical properties. Based on the comparison of phytochemical properties of this plant in different phenological stages, the highest content of total phenol and flavonoids were observed in the phonological stage of flowering and the highest (42.08%) antioxidant activity of leaves was observed in the vegetative stage. Discussion & Conclusion: The results of this study can help activists in the field of medicinal plants to determine the appropriate height range and phenological stage in harvesting the leaves of this plant to achieve the highest levels of phenol content, antioxidant activity.","PeriodicalId":16041,"journal":{"name":"journal of ilam university of medical sciences","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90546366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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