showed that the relative gene expression of SERCA2a, SERCA2b, and RYR2 were not significantly affected by HFD, ET, and HFD-ET (P>0.05). Discussion & Conclusion: The HFD and ET did not change the regulatory proteins of the futile-calcium-cycle under near-thermoneutrality in the beige adipose tissue. Therefore, it was speculated that the non-shivering thermogenesis that is induced by these conditions might occur independently of futile-cycle-calcium.
{"title":"Effect of High Fat Diet and Endurance Training on the Gene Expression of Sarco/Endoplasmic Reticulum ATPase2 (SERCA2) and Ryanodine Receptor2 (RYR2) under Near-Thermoneutrality in Inguinal Adipose Tissue of Mice","authors":"S. Daneshyar, A. Khosravi, Yazdan Fourotan","doi":"10.52547/sjimu.29.6.90","DOIUrl":"https://doi.org/10.52547/sjimu.29.6.90","url":null,"abstract":"showed that the relative gene expression of SERCA2a, SERCA2b, and RYR2 were not significantly affected by HFD, ET, and HFD-ET (P>0.05). Discussion & Conclusion: The HFD and ET did not change the regulatory proteins of the futile-calcium-cycle under near-thermoneutrality in the beige adipose tissue. Therefore, it was speculated that the non-shivering thermogenesis that is induced by these conditions might occur independently of futile-cycle-calcium.","PeriodicalId":16041,"journal":{"name":"journal of ilam university of medical sciences","volume":"53 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76326226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zahra Sokhtezari, Narmin Ghanizade, Mehri Mohammadi Dangheralo, S. Roshani
compare the effect of Cadman's and scapular rhythm on and external of the This quasi-experimental study purposefully selected 30 women with FSS with an age range of 40 to 60 years. They were then randomly divided into two equal groups to perform Cadman's and scapular rhythm exercises. Both groups performed their exercises for eight weeks, three sessions per week (30-40 min per session). The nature of Cadman's exercises was pendulum and aimed at creating initial mobility in the glenohumeral joint. The scapular rhythm exercises aimed at affecting the balance of the scapular muscles and scapulohumeral rhythm. Before and after the training intervention, the amount of shoulder pain and the range of external rotation of the shoulder were assessed using the visual analog scale and a goniometer. The results related to the pain variable showed a significant difference between the two training programs; accordingly, the scapular rhythm program was better in reducing pain than the Cadman's exercises (P=0.001). Furthermore, the motion range of the external rotation of the glenohumeral joint in the scapular rhythm program was shown to be better than that in Cadman's exercises (P=0.006). Discussion & Conclusion: Considering the effectiveness of both training programs, it can be said that the scapular rhythm training program has been better in improving the pain and motion range of the external shoulder rotation of women with FSS, and it is suggested that these exercises be included in the treatment process of these patients.
{"title":"Comparison of the Effect of Codman Exercises and Scapular Rhythm on Pain and External Rotation of Shoulder in Women with Frozen Shoulder Syndrome","authors":"Zahra Sokhtezari, Narmin Ghanizade, Mehri Mohammadi Dangheralo, S. Roshani","doi":"10.52547/sjimu.29.6.1","DOIUrl":"https://doi.org/10.52547/sjimu.29.6.1","url":null,"abstract":"compare the effect of Cadman's and scapular rhythm on and external of the This quasi-experimental study purposefully selected 30 women with FSS with an age range of 40 to 60 years. They were then randomly divided into two equal groups to perform Cadman's and scapular rhythm exercises. Both groups performed their exercises for eight weeks, three sessions per week (30-40 min per session). The nature of Cadman's exercises was pendulum and aimed at creating initial mobility in the glenohumeral joint. The scapular rhythm exercises aimed at affecting the balance of the scapular muscles and scapulohumeral rhythm. Before and after the training intervention, the amount of shoulder pain and the range of external rotation of the shoulder were assessed using the visual analog scale and a goniometer. The results related to the pain variable showed a significant difference between the two training programs; accordingly, the scapular rhythm program was better in reducing pain than the Cadman's exercises (P=0.001). Furthermore, the motion range of the external rotation of the glenohumeral joint in the scapular rhythm program was shown to be better than that in Cadman's exercises (P=0.006). Discussion & Conclusion: Considering the effectiveness of both training programs, it can be said that the scapular rhythm training program has been better in improving the pain and motion range of the external shoulder rotation of women with FSS, and it is suggested that these exercises be included in the treatment process of these patients.","PeriodicalId":16041,"journal":{"name":"journal of ilam university of medical sciences","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86484833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Article type: Research article Introduction: Chronic kidney disease (CKD) is a leading cause of death and morbidity in developed countries. Although recent studies have shown that the prevalence of thyroid disorders is higher in individuals with CKD, the underlying mechanisms are not clear. Therefore, this study aimed to evaluate the blood levels of thyroid hormones in diabetic (diabetes type 2) and non-diabetic patients with end-stage renal disease under hemodialysis treatment. Material & Methods: Thyroid-stimulating hormone (TSH), 3, 5, 3', 5'tetraiodothyronine (T4/thyroxine), and 3, 3', 5-triiodothyronine (T3), were measured. Furthermore, kidney function tests (urea and creatinine), uric acid, serum lipid profile, and fasting blood glucose were measured using spectrophotometry-based methods. (Ethic code: 991025/77) Findings: There was no significant difference between the hemodialyticdiabetic subjects (HDS) and hemodialytic-non-diabetic subjects (HNDS) regarding the levels of thyroid function hormones, including TSH, T4, and T3. However, the ratio of triiodothyronine (T3) to thyroxine (T4) (T3/T4 ratio) was significantly different between the HDS and HNDS (P<0.05). These ratios (mean±standard error of the mean) were obtained at 0.220±0.026 and 0.554±0.12 in female HDS and HNDS, respectively. On the other hand, regarding males, these ratios were determined at 0.205±0.01 and 0.295±0.05 in HDS and HNDS, respectively. Discussion & Conclusion: Homeostasis disturbance in the T3/T4 ratio hemostasis is present in HDS, compared to HNDS; however, it is not related to the hypothalamic-pituitary-thyroid axis. Peripheral factors, including the activities of iodothyronine deiodinase type 1 and type 2 enzymes, which are involved in regulating serum levels and converting T4 to T3, are probably responsible for the observed differences.
{"title":"Comparative Study of Peripheral Thyroid Hormone Homeostasis Disturbance in the Diabetic and Non-Diabetic Hemodialytic Patients","authors":"E. Anvari, A. Fateh, Ali Noori Zadeh","doi":"10.52547/sjimu.29.6.59","DOIUrl":"https://doi.org/10.52547/sjimu.29.6.59","url":null,"abstract":"Article type: Research article Introduction: Chronic kidney disease (CKD) is a leading cause of death and morbidity in developed countries. Although recent studies have shown that the prevalence of thyroid disorders is higher in individuals with CKD, the underlying mechanisms are not clear. Therefore, this study aimed to evaluate the blood levels of thyroid hormones in diabetic (diabetes type 2) and non-diabetic patients with end-stage renal disease under hemodialysis treatment. Material & Methods: Thyroid-stimulating hormone (TSH), 3, 5, 3', 5'tetraiodothyronine (T4/thyroxine), and 3, 3', 5-triiodothyronine (T3), were measured. Furthermore, kidney function tests (urea and creatinine), uric acid, serum lipid profile, and fasting blood glucose were measured using spectrophotometry-based methods. (Ethic code: 991025/77) Findings: There was no significant difference between the hemodialyticdiabetic subjects (HDS) and hemodialytic-non-diabetic subjects (HNDS) regarding the levels of thyroid function hormones, including TSH, T4, and T3. However, the ratio of triiodothyronine (T3) to thyroxine (T4) (T3/T4 ratio) was significantly different between the HDS and HNDS (P<0.05). These ratios (mean±standard error of the mean) were obtained at 0.220±0.026 and 0.554±0.12 in female HDS and HNDS, respectively. On the other hand, regarding males, these ratios were determined at 0.205±0.01 and 0.295±0.05 in HDS and HNDS, respectively. Discussion & Conclusion: Homeostasis disturbance in the T3/T4 ratio hemostasis is present in HDS, compared to HNDS; however, it is not related to the hypothalamic-pituitary-thyroid axis. Peripheral factors, including the activities of iodothyronine deiodinase type 1 and type 2 enzymes, which are involved in regulating serum levels and converting T4 to T3, are probably responsible for the observed differences.","PeriodicalId":16041,"journal":{"name":"journal of ilam university of medical sciences","volume":"208 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81891540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: The goal of this study was effectiveness of mindfulness based on stress managment on death anxiety, disaster of imagination, acceptance and severity of pain in prostat cancer patients. Material & Methods: The research design was experimental pre-test and post-test with control group. At first, 40 hospitalized men in a treatment center were selected by using the purposive sampling method. The experimental group were treated for eight 45-minute sessions by training mindfulness based on stress managment. All subjects completed the questionnaire at the beginning of the study, after the intervention and one month after the treatment (one-month follow up). For data analysis, Multivariate Analysis of Variance were used. (Ethic code: IR-IAU-AHVAZ-REC-1400-029) Findings: The results indicated that mindfulness based on stress managment in the control group were more effective in death anxiety, disaster of imagination, acceptance and severity of pain in prostat cancer patients. (p=0/001). The results of follow-ups also showed that the effect of mindfulness based on stress managment was sustained on death anxiety, disaster of imagination, acceptance and severity of pain in prostat cancer patients. Discussion & Conclusion: The use of mindfulness based on stress managment method is recommended as effective treatment method on death anxiety, disaster of imagination, acceptance and severity of pain in prostat cancer patients.
{"title":"The Effectiveness of Mindfulness Based on Stress Managment on Death Anxiety, Disaster of Imagination, Acceptance and Severity of Pain in Prostat Cancer Patients","authors":"M. Haghdoost, Naser Sarajkhorrami, B. Makvandi","doi":"10.52547/sjimu.29.6.48","DOIUrl":"https://doi.org/10.52547/sjimu.29.6.48","url":null,"abstract":"Introduction: The goal of this study was effectiveness of mindfulness based on stress managment on death anxiety, disaster of imagination, acceptance and severity of pain in prostat cancer patients. Material & Methods: The research design was experimental pre-test and post-test with control group. At first, 40 hospitalized men in a treatment center were selected by using the purposive sampling method. The experimental group were treated for eight 45-minute sessions by training mindfulness based on stress managment. All subjects completed the questionnaire at the beginning of the study, after the intervention and one month after the treatment (one-month follow up). For data analysis, Multivariate Analysis of Variance were used. (Ethic code: IR-IAU-AHVAZ-REC-1400-029) Findings: The results indicated that mindfulness based on stress managment in the control group were more effective in death anxiety, disaster of imagination, acceptance and severity of pain in prostat cancer patients. (p=0/001). The results of follow-ups also showed that the effect of mindfulness based on stress managment was sustained on death anxiety, disaster of imagination, acceptance and severity of pain in prostat cancer patients. Discussion & Conclusion: The use of mindfulness based on stress managment method is recommended as effective treatment method on death anxiety, disaster of imagination, acceptance and severity of pain in prostat cancer patients.","PeriodicalId":16041,"journal":{"name":"journal of ilam university of medical sciences","volume":"198 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77550292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
use of CBCT was for intraoral investigations. Moreover, the maximum cases of using CBCT was for extraoral investigations. The most important reason for not using CBCT was because of high cost (54%), and the most correct answers of the respondents were about knowledge and the application of CBCT in determining the position of the implants before surgery (96%). The knowledge of the general dentists was (47.884%) which was classified in a low group. Discussion & Conclusion: The findings from this study showed that the knowledge level of general dentists in Ilam about CBCT was nearly low, and the maximum level of the knowledge belonged to the experienced ones.
{"title":"General Dentists' Knowledge and Attitude toward Prescriptions as well as Advantages and Disadvantages of Cone-beam Computed Tomography in Ilam, Iran, in 2019","authors":"S. Haidari, Khadijeh Abdal, Masood Nikeghbal","doi":"10.52547/sjimu.29.6.28","DOIUrl":"https://doi.org/10.52547/sjimu.29.6.28","url":null,"abstract":"use of CBCT was for intraoral investigations. Moreover, the maximum cases of using CBCT was for extraoral investigations. The most important reason for not using CBCT was because of high cost (54%), and the most correct answers of the respondents were about knowledge and the application of CBCT in determining the position of the implants before surgery (96%). The knowledge of the general dentists was (47.884%) which was classified in a low group. Discussion & Conclusion: The findings from this study showed that the knowledge level of general dentists in Ilam about CBCT was nearly low, and the maximum level of the knowledge belonged to the experienced ones.","PeriodicalId":16041,"journal":{"name":"journal of ilam university of medical sciences","volume":"52 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77431786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Fatemeh Javani Jouni, Jaber Zafari, Elahe Shams, P. Abdolmaleki, A. Rastegari
most to evaluate the anti-cancer effects of Naja naja oxiana in comparison with doxorubicin in Hela (Human cervical cancer) and HFF (Human foreskin fibroblast) Material & Methods: Hela and normal fibroblast cancer cell lines were exposed to different concentrations (1, 10, 50, 100, and 500 μg/ml) of snake venom and doxorubicin. The MTT method was used to evaluate the IC50 (Inhibitory Concentration) for toxins and drugs. Finally, the results were analyzed using SPSS software (version 19). Findings: The results show that with increasing concentration and time of treatment with snake venom and doxorubicin, the percentage of Hela and fibroblasts living cells decreases. The highest decrease in the percentage of the viable cells was observed in the Hela cancer cell line treated with a concentration of 500 μg/ml snake venom for 48 h. Discussion & Conclusion: Snake venom can have a significant inhibitory effect on the percentage of living Hela cancer cells in comparison with doxorubicin.
{"title":"Evaluation of Anti-Cancer Effects of Caspian Cobra (Naja naja oxiana) Snake Venom in Comparison with Doxorubicin in HeLa Cancer Cell Line and Normal HFF Fibroblast","authors":"Fatemeh Javani Jouni, Jaber Zafari, Elahe Shams, P. Abdolmaleki, A. Rastegari","doi":"10.52547/sjimu.29.6.20","DOIUrl":"https://doi.org/10.52547/sjimu.29.6.20","url":null,"abstract":"most to evaluate the anti-cancer effects of Naja naja oxiana in comparison with doxorubicin in Hela (Human cervical cancer) and HFF (Human foreskin fibroblast) Material & Methods: Hela and normal fibroblast cancer cell lines were exposed to different concentrations (1, 10, 50, 100, and 500 μg/ml) of snake venom and doxorubicin. The MTT method was used to evaluate the IC50 (Inhibitory Concentration) for toxins and drugs. Finally, the results were analyzed using SPSS software (version 19). Findings: The results show that with increasing concentration and time of treatment with snake venom and doxorubicin, the percentage of Hela and fibroblasts living cells decreases. The highest decrease in the percentage of the viable cells was observed in the Hela cancer cell line treated with a concentration of 500 μg/ml snake venom for 48 h. Discussion & Conclusion: Snake venom can have a significant inhibitory effect on the percentage of living Hela cancer cells in comparison with doxorubicin.","PeriodicalId":16041,"journal":{"name":"journal of ilam university of medical sciences","volume":"134 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89440320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
to the death of the mice in the control group. However, in the first and second groups treated with liposomes containing peptide and nanoparticle albumin, at the beginning of the fifth week, the wound size got smaller, and the recovery process initiated (P<0.05). Discussion & Conclusion: The results of this part of the study showed that the therapeutic effects with liposome carriers and albumin nanoparticles containing 25 μg/ml activated melittin in mice with leishmaniasis can be compared with those of the control group. Liposome and nanoparticle carriers of albumin-containing activated melittin have been suggested as an effective, appropriate, and even alternative treatment for cutaneous leishmaniasis .
{"title":"Evaluation of the Effect of Liposome Carriers and Albumin Nanoparticles Containing Activated Melittin on Inhibiting the Growth of Leishmania Major Amastigote in vivo","authors":"Soheyla Akhzari, S. Nabian, P. Shayan, M. Taheri","doi":"10.52547/sjimu.29.6.36","DOIUrl":"https://doi.org/10.52547/sjimu.29.6.36","url":null,"abstract":"to the death of the mice in the control group. However, in the first and second groups treated with liposomes containing peptide and nanoparticle albumin, at the beginning of the fifth week, the wound size got smaller, and the recovery process initiated (P<0.05). Discussion & Conclusion: The results of this part of the study showed that the therapeutic effects with liposome carriers and albumin nanoparticles containing 25 μg/ml activated melittin in mice with leishmaniasis can be compared with those of the control group. Liposome and nanoparticle carriers of albumin-containing activated melittin have been suggested as an effective, appropriate, and even alternative treatment for cutaneous leishmaniasis .","PeriodicalId":16041,"journal":{"name":"journal of ilam university of medical sciences","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88245277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Seideh madineh Ghasemnegad, S. A. Haghayegh, S. Jahanian, Hasan Rezaeijamalouei
Article type: Research article Introduction: Asthma is a major health problem in most parts of the world. This chronic disease is influenced by psychological therapies, such as cognitive-behavioral therapy, and training, such as diaphragmatic respiratory exercises. This study aimed to compare the effectiveness of cognitive-behavioral therapy and training of diaphragmatic respiratory exercises on panic symptoms in women with asthma in Lahijan, Iran, in 2020. Material & Methods: This quasi-experimental study was conducted on two groups using a pre-test and post-test design with a control group. A total of 60 women who were referred to the clinics or hospitals in Lahijan, Iran, in 2020, were selected through the available sampling method and randomly divided into three groups of cognitive-behavioral therapy, diaphragmatic respiratory training, and control. Pre-tests were taken from the samples before the interventions. After the interventions, post-tests were administered, and the patients were followed up one month later. The data were collected using the Albani Panic Disorder Questionnaire, designed in 1996 by Barlow and Zeinberg. The obtained data were then analyzed using SPSS software (version 22) through descriptive statistics (mean±SD and variance) and inferential statistics (variance analysis and Bonferroni test). (Ethic code: IR.IAU.NAJAFABAD.REC.1399.048) Findings: The results of the study showed that cognitive-behavioral therapy at the post-test (62.43±3.96) and training of diaphragmatic respiratory exercises at the follow-up phase (55.64±2.58) were more effective in improving the panic symptoms of women with asthma (P=0.0001). Discussion & Conclusion: The use of methods, such as cognitivebehavioral therapy, and changes in the lifestyle (regular physical activity) of asthmatic patients can play a helpful role in controlling asthma panic symptoms.
{"title":"Comparison of the Effectiveness of Cognitive Behavioral Therapy and Training of Diaphragmatic Respiratory Exercises on Panic Symptoms in Women with Asthma","authors":"Seideh madineh Ghasemnegad, S. A. Haghayegh, S. Jahanian, Hasan Rezaeijamalouei","doi":"10.52547/sjimu.29.6.11","DOIUrl":"https://doi.org/10.52547/sjimu.29.6.11","url":null,"abstract":"Article type: Research article Introduction: Asthma is a major health problem in most parts of the world. This chronic disease is influenced by psychological therapies, such as cognitive-behavioral therapy, and training, such as diaphragmatic respiratory exercises. This study aimed to compare the effectiveness of cognitive-behavioral therapy and training of diaphragmatic respiratory exercises on panic symptoms in women with asthma in Lahijan, Iran, in 2020. Material & Methods: This quasi-experimental study was conducted on two groups using a pre-test and post-test design with a control group. A total of 60 women who were referred to the clinics or hospitals in Lahijan, Iran, in 2020, were selected through the available sampling method and randomly divided into three groups of cognitive-behavioral therapy, diaphragmatic respiratory training, and control. Pre-tests were taken from the samples before the interventions. After the interventions, post-tests were administered, and the patients were followed up one month later. The data were collected using the Albani Panic Disorder Questionnaire, designed in 1996 by Barlow and Zeinberg. The obtained data were then analyzed using SPSS software (version 22) through descriptive statistics (mean±SD and variance) and inferential statistics (variance analysis and Bonferroni test). (Ethic code: IR.IAU.NAJAFABAD.REC.1399.048) Findings: The results of the study showed that cognitive-behavioral therapy at the post-test (62.43±3.96) and training of diaphragmatic respiratory exercises at the follow-up phase (55.64±2.58) were more effective in improving the panic symptoms of women with asthma (P=0.0001). Discussion & Conclusion: The use of methods, such as cognitivebehavioral therapy, and changes in the lifestyle (regular physical activity) of asthmatic patients can play a helpful role in controlling asthma panic symptoms.","PeriodicalId":16041,"journal":{"name":"journal of ilam university of medical sciences","volume":"53 1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78442353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Z. Shykholeslami, Ahmad Abdi, S. Hosseini, A. Barari
Introduction: Aging impairs the function of genes involved in hepatic metabolisms, such as Mitogen-activated protein kinase (AMPK) and Phosphatidylinositol 3-kinases (PI3K). Exercise and Citrus Aurantium (CA) have a beneficial effect on improving metabolic factors in aging. This study aimed to investigate the effect of aerobic training (T) with consumption of CA on the AMPK and PI3K gene expression levels in the liver tissue of elderly rats . Material & Methods: In this experimental study, 25 elderly female rats were divided into five groups of five animals per group. The groups included 1) control, 2) sham, 3) CA, 4) T, and 5) T+CA. Over the course of eight weeks, the T groups ran on the treadmill three sessions per week at 65% to 75% of the maximum running speed for 15 min in the first week to 31 min in the eighth week. The supplement groups also received 300 mg/kg/day of CA extract peritoneal. After 48 h of the last training session and CA consumption, AMPK and PI3K gene expression levels in the liver tissue were measured by the real-time PCR method . (Ethic code: IR.IAU.M.REC.1399.032) Findings: AMPK expression was significantly increased in CA (P=0.043), T (P=0.025,) and T+CA (P=0.009) groups, compared to the control group. Moreover, a significant increase in the PI3K expression was observed in the T+CA (P=0.031) group, compared to the control group . Discussion & Conclusion: The results of the present study showed that T and CA might improve liver cell function in elderly rats by increasing the expression of AMPK and PI3K genes .
{"title":"Effect of Continuous Aerobic Training with Citrus Aurantium L. on Mitogen-Activated Protein Kinase and Phosphatidylinositol 3-Kinases Gene Expression in the Liver Tissue of the Elderly Rats","authors":"Z. Shykholeslami, Ahmad Abdi, S. Hosseini, A. Barari","doi":"10.52547/sjimu.29.6.81","DOIUrl":"https://doi.org/10.52547/sjimu.29.6.81","url":null,"abstract":"Introduction: Aging impairs the function of genes involved in hepatic metabolisms, such as Mitogen-activated protein kinase (AMPK) and Phosphatidylinositol 3-kinases (PI3K). Exercise and Citrus Aurantium (CA) have a beneficial effect on improving metabolic factors in aging. This study aimed to investigate the effect of aerobic training (T) with consumption of CA on the AMPK and PI3K gene expression levels in the liver tissue of elderly rats . Material & Methods: In this experimental study, 25 elderly female rats were divided into five groups of five animals per group. The groups included 1) control, 2) sham, 3) CA, 4) T, and 5) T+CA. Over the course of eight weeks, the T groups ran on the treadmill three sessions per week at 65% to 75% of the maximum running speed for 15 min in the first week to 31 min in the eighth week. The supplement groups also received 300 mg/kg/day of CA extract peritoneal. After 48 h of the last training session and CA consumption, AMPK and PI3K gene expression levels in the liver tissue were measured by the real-time PCR method . (Ethic code: IR.IAU.M.REC.1399.032) Findings: AMPK expression was significantly increased in CA (P=0.043), T (P=0.025,) and T+CA (P=0.009) groups, compared to the control group. Moreover, a significant increase in the PI3K expression was observed in the T+CA (P=0.031) group, compared to the control group . Discussion & Conclusion: The results of the present study showed that T and CA might improve liver cell function in elderly rats by increasing the expression of AMPK and PI3K genes .","PeriodicalId":16041,"journal":{"name":"journal of ilam university of medical sciences","volume":"34 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82425868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
R. Jafari Nodoushan, A. Sadri Esfahani, Tahmasb Akhtar, Kh Taherzadeh Chenani
Introduction: Human error plays a significant role in the occurrence of industrial accidents. Displacement and unloading operations are operations in which the occurrence of human error may lead to plenty of human and financial losses. The present study aimed to investigate the possibility of human error occurrence in overhead crane operators in a Steel Company in Hormozgan, Iran. Material & Methods: This cross-sectional and descriptive study was conducted using the Standardized Plant Analysis Risk-Human Reliability Analysis (SPAR-H) technique. In this study, the job tasks of overhead crane operators were firstly analyzed using the hierarchical task analysis (HTA) technique. Subsequently, the probability of human error in job tasks was assessed using the SPAR-H technique. (Ethic code: IR.ACECR.JDM.REC.1399.005) Findings: Generally, five main tasks and 16 sub-tasks have been analyzed in this study. The highest probability of error was related to the three sub-tasks of longitudinal motion, transverse motion, and high and low motion (0.3975). The lowest probability of error was under the duty of recording shift reports, transmitting information orally, and writing (0.05). The results of this study clearly showed the effect of interdependence on increasing the probability of error occurrence. Discussion & Conclusion: Based on the results of the present study, some preventive measures were proposed to reduce the possibility of human error, including identifying and controlling job stressors, correcting the ergonomic status of crane cabins, preparing work instructions, as well as training and monitoring their proper implementation.
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