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The Effect of Acceptance and Commitment Therapy on Muscle Pain in Patients with Rheumatoid Arthritis 接受与承诺治疗对类风湿关节炎患者肌肉疼痛的影响
Pub Date : 2022-06-01 DOI: 10.52547/sjimu.30.2.51
Soheyla Malek-Mohammadi-Memar, Mohammad Reza Zoghi Paydar
The
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引用次数: 0
Effects of Eight Weeks of High-Intensity Interval Training on the Expression of the Nkx2.5 and Tbx5 Genes in the Heart Tissue of Type 2 Male Diabetic Rats 8周高强度间歇训练对2型雄性糖尿病大鼠心脏组织Nkx2.5和Tbx5基因表达的影响
Pub Date : 2022-06-01 DOI: 10.52547/sjimu.30.2.71
M. Kousha, Hossein Abednatanzi, M. Gholami, F. Ghazalian
Introduction: Exercise and antioxidants consumption are known as protective effect against the risk of diabetes. Therefore, the current study aimed to investigate the effects of eight weeks of high-intensity interval training (HIIT) and thyme honey on the expression of Nkx2.5 and Tbx5 genes in the heart tissue of male type 2 diabetic rats. Material & Methods: This experimental study was performed on 36 male diabetic rats which were randomly divided into four groups of control (n=8), HIIT (n=10), thyme honey (n=8), and HIIT+thyme honey (n=10). The HIIT training intervention was conducted in eight weeks (five sessions per week) and included 2 to 8 intervals with 2 min running at 80%-90% VO2max and 1 min at 50%-56% VO2max. Additionally, the supplement groups consumed 3 g/kg of thyme honey, 5 days/week. Both Nkx2.5 and Tbx5 gene expression in heart tissue were measured using real-time RT-PCR. To evaluate the differences among the groups, ANOVA and LSD post hoc tests were used at the significance level of P≤0.05. (Ethic code: IR.SSRC.REC.1399.080) Findings: The results revealed that the expression of the Nkx2.5 gene was significantly increased only in the HIIT group, compared to the control group (P=0.03); however, it was not observed in other intervention groups (P>0.05). The expression of the Tbx5 gene was significantly increased in both HIIT (P=0.02) and HIIT+thyme honey (P=0.02) groups, compared to the control group. Discussion & Conclusion: The HIIT is associated with increased expression of the Nkx2.5 and Tbx5 genes in the heart tissue of diabetic rats; however, it can not be said exactly that thyme honey has similar effects in diabetic rats.
导读:运动和抗氧化剂的摄入被认为对预防糖尿病有保护作用。因此,本研究旨在探讨8周高强度间歇训练(HIIT)和百里香蜂蜜对雄性2型糖尿病大鼠心脏组织中Nkx2.5和Tbx5基因表达的影响。材料与方法:选取36只雄性糖尿病大鼠,随机分为对照组(n=8)、HIIT组(n=10)、百里香蜂蜜组(n=8)、HIIT+百里香蜂蜜组(n=10)。HIIT训练干预在8周内进行(每周5次),包括2到8次间歇,其中2分钟以80%-90%的VO2max跑,1分钟以50%-56%的VO2max跑。此外,补充组每公斤食用3克百里香蜂蜜,每周5天。采用实时RT-PCR法检测Nkx2.5和Tbx5基因在心脏组织中的表达。在P≤0.05的显著性水平上,采用方差分析和LSD事后检验来评价组间差异。(伦理代码:IR.SSRC.REC.1399.080)结果显示,与对照组相比,只有HIIT组Nkx2.5基因的表达显著升高(P=0.03);其他干预组无明显差异(P < 0.05)。与对照组相比,HIIT组(P=0.02)和HIIT+百里香蜂蜜组(P=0.02) Tbx5基因的表达均显著升高。讨论与结论:HIIT与糖尿病大鼠心脏组织中Nkx2.5、Tbx5基因表达升高有关;然而,不能确切地说百里香蜂蜜对糖尿病大鼠有类似的效果。
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引用次数: 0
Comparison of Effectiveness of Acceptance and Commitment Therapy (ACT) and Compassion-Focused Therapy (CFT) on Internalized Shame in Patients with Vitiligo 接受与承诺疗法(ACT)与同情疗法(CFT)治疗白癜风患者内化羞耻感的效果比较
Pub Date : 2022-06-01 DOI: 10.52547/sjimu.30.2.82
M. Solimanpour, A. Pirkhaefi, K. Zahrakar
Introduction: Skin diseases, not only may have physical consequences but also costly psychological consequences in one’s life. The present study was conducted to compare the effect of group counseling with the approaches of Compassion-Focused Therapy (CFT) and Acceptance and Commitment Therapy (ACT) on the internalized shame of patients with vitiligo. Material & Methods: This was a quasi-experimental study with pre-test and post-test design and follow-up and control groups. The study population consisted of all women with vitiligo who were referred to Razi Hospital, in Tehran, in 1399. A total of 45 persons who met the inclusion criteria were purposefully selected and randomly divided into 3 groups of 15 people each (two experimental groups and one control group). The study tool included Cook's Internalized Shame Scale (1993). Descriptive statistics and repeated measures analysis of variance was used to test the research hypotheses. The data were analyzed using SPSS software (version 20). (Ethic code: R.IAU.SRB.REC.1399.125) Findings: Both CFT and ACT therapeutic approaches were effective in reducing internalized shame in patients with vitiligo, compared to the control group. A comparison of the two approaches showed no significant differences between the two experimental groups of CFT and ACT in terms of all components of shyness, self-esteem, and internalized shame. Discussion & Conclusion: Based on the obtained results, the above-mentioned treatments can be used to improve the psychological status of patients with vitiligo.
简介:皮肤病不仅会对身体造成严重后果,还会对人的一生造成严重的心理后果。本研究旨在比较团体辅导与慈悲聚焦疗法(CFT)和接纳与承诺疗法(ACT)对白癜风患者内化羞耻感的影响。材料与方法:本研究为准实验研究,采用测试前和测试后设计,随访组和对照组。研究人群包括1399年在德黑兰Razi医院转诊的所有白癜风妇女。有目的地选择符合纳入标准的45人,随机分为3组,每组15人(2个实验组和1个对照组)。研究工具包括库克的内化羞耻量表(1993)。采用描述性统计和重复测量方差分析对研究假设进行检验。采用SPSS软件(version 20)对数据进行分析。(伦理准则:R.IAU.SRB.REC.1399.125)研究结果:与对照组相比,CFT和ACT治疗方法均能有效减少白癜风患者的内化羞耻感。两种方法的比较表明,CFT和ACT两个实验组在羞怯、自尊和内化羞耻的所有组成部分方面没有显著差异。讨论与结论:根据所获得的结果,上述治疗方法可以改善白癜风患者的心理状态。
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引用次数: 2
Role of Experiential Avoidance and Alexithymia in the Prediction of Psychosomatic Disorder among the Employees at National Iranian South Oil Company 伊朗国家南方石油公司员工体验性回避和述情障碍在心身障碍预测中的作用
Pub Date : 2022-06-01 DOI: 10.52547/sjimu.30.2.63
Ali Molaei pardh, J. Karami, Asieh Moradi
Introduction: Psychosomatic disorder is one of the most common mental disorders in which meaningful psychological events play an effective role. This study aimed to investigate the role of experiential avoidance and alexithymia in the prediction of psychosomatics disorder among the employees at the national Iranian south oil company. Material & Methods: The statistical population of this descriptive correlational study included all employees at the national Iranian south oil company from 2020 to 2021. The sample size of the present study was obtained at 371 people based on Cochran's formula. Due to the possibility of incomplete questionnaires, 418 employees were selected by the available sampling method. They were then requested to complete the Symptom Checklist-90 (SCL-90), experiential avoidance (AAQ), and alexithymia (FTAS-20). (Ethic code: 140090) Findings: The results of the Pearson correlation coefficient showed a correlation coefficient of 0.39 between experiential avoidance and psychosomatic disorder which was significant at 0.001. Moreover, there was a correlation coefficient of 0.15 between alexithymia and psychosomatic disorder, which was significant at 0.003. In addition, the results of linear regression analysis showed that experiential avoidance could predict psychosomatic disorders. Discussion & Conclusion: Therefore, according to the findings, in order to reduce psychosomatic disorders, it is necessary to conduct interventions on psychological flexibility and emotional expression. Finally, it is suggested that other empirical and quasi-experimental studies be conducted to confirm these results.
心身障碍是最常见的精神障碍之一,有意义的心理事件在其中起着有效的作用。本研究旨在探讨经验回避和述情障碍在伊朗国家南方石油公司员工身心障碍预测中的作用。材料与方法:本描述性相关研究的统计人群包括2020年至2021年伊朗国家南方石油公司的所有员工。根据科克伦公式,本研究的样本量为371人。考虑到问卷可能不完整,通过现有的抽样方法选取了418名员工。然后要求他们完成症状检查表90 (SCL-90)、经验回避(AAQ)和述情障碍(FTAS-20)。(伦理代码:140090)研究结果:Pearson相关系数结果显示,体验性回避与心身障碍的相关系数为0.39,显著性为0.001。此外,述情障碍与心身障碍的相关系数为0.15,显著性为0.003。此外,线性回归分析结果显示,经验回避可以预测心身障碍。讨论与结论:因此,根据研究结果,为了减少心身障碍,有必要对心理灵活性和情绪表达进行干预。最后,建议进行其他实证和准实验研究来证实这些结果。
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引用次数: 0
Study of Human Albumin Protein Interaction with Fluorouracil Anticancer Drug Using Molecular Docking Method 人白蛋白与氟尿嘧啶抗癌药物相互作用的分子对接研究
Pub Date : 2022-06-01 DOI: 10.52547/sjimu.30.2.32
Mohammad Motaharinia, Mahdieh Sadeghpour, M. Shalbafan
has an aliphatic ring and hydrophobic fractions and therefore it has a high ability to form hydrophobic interactions with major amino acids at the active site of serum albumin protein.
具有脂肪环和疏水组分,因此它具有与血清白蛋白活性部位的主要氨基酸形成疏水相互作用的高能力。
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引用次数: 0
Explaining the Effective Dimensions and Components for Community-Based Medical Education from the Perspective of Family Physicians of Ilam University of Medical Sciences: A Qualitative Study 从伊拉姆医科大学家庭医生的角度解释社区医学教育的有效维度和成分:一项定性研究
Pub Date : 2022-06-01 DOI: 10.52547/sjimu.30.2.8
Zohreh sadat Mirmoghtadaaie, S. Ahmady, Hojjatolah Abdoullahi
the
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引用次数: 0
Editing of the MALAT1 Gene in MDA-MB-361 Breast Cancer Cell Line using the Novel CRISPR Method 利用新型CRISPR方法编辑MDA-MB-361乳腺癌细胞系MALAT1基因
Pub Date : 2022-06-01 DOI: 10.52547/sjimu.30.2.18
Soraya Ahmadi-Baloutaki, A. Doosti, Mojtaba Jaafarinia, H. Goudarzi
The expression of genes related to apoptosis was analyzed by Real-Time PCR. Cell proliferation and apoptosis were assessed by MTT and flow cytometry methods, respectively. (Ethic code: IR.IAU.M.REC.1399.010) Findings: The MALAT1 gene was edited by the CRISPR method in MDA-MB-361 cells. The rate of cell proliferation in the cells of the treatment group, compared to the control groups, showed a significant decrease (P<0.05). Apoptosis levels were significantly increased in cancer cells the MALAT1 gene of which had been deleted. Moreover, the expression of BCL2 and survivin anti-apoptotic genes in treated (edited) cells was significantly reduced, compared to control cells (P<0.05). Increased expression of proapoptotic genes P53, BAK, BAX, and FAS was also observed in the edited cells (P<0.05). Discussion & Conclusion: The results of this study confirm that the deletion of the MALAT1 gene has a significant effect on increasing apoptosis and reducing cell proliferation. A reduction in the expression of the MALAT1 gene can prevent the growth and proliferation of breast cancer cell lines. Therefore, it seems that the control of MALAT1 oncogene expression is useful and effective for controlling tumors.
Real-Time PCR检测细胞凋亡相关基因的表达。分别用MTT和流式细胞术检测细胞增殖和凋亡。(伦理代码:ir . iau . m.c rec .1399.010)研究结果:利用CRISPR方法在MDA-MB-361细胞中编辑了MALAT1基因。与对照组相比,治疗组细胞的增殖率显著降低(P<0.05)。在MALAT1基因缺失的癌细胞中,细胞凋亡水平显著升高。此外,BCL2和survivin抗凋亡基因在处理(编辑)细胞中的表达与对照细胞相比显著降低(P<0.05)。编辑后细胞中促凋亡基因P53、BAK、BAX、FAS表达增加(P<0.05)。讨论与结论:本研究结果证实了MALAT1基因的缺失对增加细胞凋亡和降低细胞增殖具有显著作用。MALAT1基因表达的减少可以阻止乳腺癌细胞系的生长和增殖。因此,似乎控制MALAT1癌基因的表达对于控制肿瘤是有用和有效的。
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引用次数: 1
Antimicrobial Effects of Aqueous-Alcoholic Extract of Artemisia Turanica against Methicillin-Resistant Staphylococcus aureus (MRSA): An in vitro Study 图兰蒿水醇提取物对耐甲氧西林金黄色葡萄球菌(MRSA)抗菌作用的体外研究
Pub Date : 2022-06-01 DOI: 10.52547/sjimu.30.2.1
Hasan Bagheri yazdi, Hamed Norouzi taheri
Introduction: Infections caused by methicillin-resistant Staphylococcus aureus (MRSA) are on the rise worldwide. Over the last few decades, new compounds of natural origins have regained interest as an alternative to antibiotics in the treatment of MRSA infections. This study aimed to investigate the antimicrobial effects of Artemisia Turanica extract, a native plant of Iran. Material & Methods: The plant was subjected to aqueous-alcoholic extraction, and its antibacterial effects were then evaluated using the disk diffusion method. All tests were performed in triplicate, and the mean diameter of the growth inhibition zone was recorded. Finally, the minimum inhibitory concentrations and minimum bactericidal concentrations (MIC and MBC) against MRSA were determined using the micro broth dilution method . (Ethic
导读:耐甲氧西林金黄色葡萄球菌(MRSA)引起的感染在世界范围内呈上升趋势。在过去的几十年里,天然来源的新化合物作为抗生素治疗MRSA感染的替代品重新引起了人们的兴趣。本研究旨在研究伊朗本土植物图兰蒿提取物的抗菌作用。材料与方法:采用水醇萃取法,采用圆盘扩散法对其抑菌效果进行评价。所有试验均进行了三次,并记录了生长抑制带的平均直径。最后,采用微肉汤稀释法测定对MRSA的最低抑菌浓度和最低杀菌浓度(MIC和MBC)。(伦理
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引用次数: 1
Synergistic Effect of Silver Nanoparticles and Streptomycin Antibiotic on the MexX Gene Expression of Pump Efflux System in Drug-Resistant Pseudomonas aeruginosa Strains 纳米银与链霉素对耐药铜绿假单胞菌泵外系统MexX基因表达的协同作用
Pub Date : 2022-06-01 DOI: 10.52547/sjimu.30.2.41
A. Mohammad, Farahnaz - Molavi, S. Dolatabadi
Introduction
介绍
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引用次数: 1
Relationship of Bacteria Isolated from Antral Gastric Biopsy with the Incidence of Dyspepsia in Patients Referred to Mehrad and Labbafinejad Hospitals, Tehran, Iran, in 2018 2018年伊朗德黑兰Mehrad和Labbafinejad医院转诊患者胃窦活检分离细菌与消化不良发生率的关系
Pub Date : 2022-03-01 DOI: 10.52547/sjimu.30.1.85
Mahnaz Mohammadi, A. Talebi Bezmin abadi, F. Rahimi, M. Forootan
alone increased the sperm count, motility, and viability; moreover, they decreased the abnormal sperms, compared to the CIS group (P<0.001). Discussion & Conclusion: The results of the current study demonstrated that CIS decreased sperm quality, and the coadministration of Boswellia thurifera aqueous extract reduced CIS-induced cytotoxicity and improved the sperm quality. In conclusion, the Boswellia thurifera aqueous extract is useful for the reduction of limitationthe toxic effects of CIS and improvement of the parameters of sperm quality.
单独增加精子数量、活力和生存能力;与CIS组相比,异常精子数量明显减少(P<0.001)。讨论与结论:本研究结果表明,CIS降低了精子质量,同时给药可降低CIS诱导的细胞毒性,提高精子质量。由此可见,黄花乳香水提物对减少CIS的限制、降低其毒性作用、改善精子质量等指标具有重要意义。
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引用次数: 0
期刊
journal of ilam university of medical sciences
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