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From skull to face: MRI vs. CBCT-based soft tissue depths in forensic 3D craniofacial reconstruction 从颅骨到面部:MRI与基于cbct的法医三维颅面重建软组织深度。
IF 1.2 4区 医学 Q3 MEDICINE, LEGAL Pub Date : 2026-02-01 Epub Date: 2026-01-02 DOI: 10.1016/j.jflm.2026.103073
Anurag Dubey , Raja Rupani , Garima Sehgal , Anit Parihar , Ashutosh Deo Tiwari , Shiuli Rathore , Anoop Kumar Verma , Abhishek Mishra , Sandeep Bhattacharya
Facial soft tissue thickness (FSTT) constitutes one of the most critical variables in forensic craniofacial reconstruction, and the application of advanced imaging modalities such as magnetic resonance imaging (MRI) and cone-beam computed tomography (CBCT) can strengthen confidence in these technologies. Using MRI, we evaluated FSTT at 29 anatomical landmarks in 36 healthy adults. We conducted standardised infrared facial imaging on the same participants to obtain 26 anthropometric measurements. We generated three digital facial reconstructions using anonymised three-dimensional skull models and ZBrush software. Under double-blinded conditions, we reconstructed two skulls, one male and one female. In the female case, we applied a postural correction factor to account for the supine imaging orientation, whereas we completed the male reconstruction without adjustment. We assessed the anatomical accuracy of both reconstructions using public recognition surveys and facial resemblance analysis with FaceVACS software. For the third case, we applied region-specific FSTT values derived from CBCT in a real forensic investigation in Karnataka, India. Investigators disseminated the reconstructed face as an investigative aid and subsequently contributed to the identification of a missing person, with identity confirmed through police records. These findings indicate that posture-corrected MRI-derived data and regionally calibrated CBCT datasets improve anatomical accuracy in three-dimensional facial reconstruction, thereby enhancing its utility in forensic identification, particularly within the Indian context.
面部软组织厚度(FSTT)是法医颅面重建中最关键的变量之一,而磁共振成像(MRI)和锥束计算机断层扫描(CBCT)等先进成像技术的应用可以增强对这些技术的信心。使用MRI,我们评估了36名健康成人的29个解剖标志的FSTT。我们对相同的参与者进行了标准化的红外面部成像,以获得26个人体测量值。我们使用匿名三维头骨模型和ZBrush软件生成了三个数字面部重建。在双盲条件下,我们重建了两个头骨,一个是男性,一个是女性。在女性病例中,我们应用姿势校正因子来解释仰卧位成像方向,而我们在没有调整的情况下完成了男性重建。我们使用公众识别调查和FaceVACS软件进行面部相似性分析来评估两种重建的解剖学准确性。对于第三个案例,我们在印度卡纳塔克邦的真实法医调查中应用了来自CBCT的区域特定FSTT值。调查人员将重建的脸作为一种调查手段传播开来,随后帮助确认了一名失踪者的身份,并通过警方记录确认了他的身份。这些发现表明,姿势校正的mri衍生数据和区域校准的CBCT数据集提高了三维面部重建的解剖学准确性,从而增强了其在法医鉴定中的实用性,特别是在印度背景下。
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引用次数: 0
Examining the role of cyanide poisoning in the autopsies of closed-space fire deaths in Istanbul (Türkiye) 审查氰化物中毒在伊斯坦布尔封闭空间火灾死亡尸体解剖中的作用(t<s:1> rkiye)。
IF 1.2 4区 医学 Q3 MEDICINE, LEGAL Pub Date : 2026-02-01 Epub Date: 2026-01-03 DOI: 10.1016/j.jflm.2026.103071
Mustafa Okudan , Doruktan Tufekci , Fatma Ofluoglu , Mahmut Asirdizer

Background

Most deaths in closed-space fires occur due to inhalation of carbon monoxide, hydrogen cyanide, and other gases in the environment.

Material and methods

This study retrospectively examined 42 forensic autopsy reports and the associated crime scene reports of individuals who died in indoor fires. The autopsies were performed at the Morgue Department of the Forensic Medicine Institute in 2022 and 2023.

Results

Cyanide analysis was not conducted in 33.3 % of the 42 cases, and cyanide was detected in only 10.7 % of the 28 cases in which blood cyanide analysis was requested. All cases had positive carboxyhemoglobin levels, although 76.2 % of cases had HbCO values more than 10 %. More than half of the deaths occurred at the scene, primarily in the victims' homes. All cases had burns on their bodies, ranging from second degree to carbonization degree, and soot contamination in the upper and lower respiratory tracts was determined in 77.7 %. The toxicological analysis of blood from victims who received medical treatment, either in ambulances or hospitals, showed no evidence of antidote administration.

Conclusion

The findings of this study highlight the importance of collecting blood samples from the bodies of those who have died at the fire scene, administering cyanide antidotes to survivors via immediate intravenous injection after smoke exposure, and testing survivors for metabolites due to the short half-life of cyanide. For the prevention of cyanide poisoning exposure, and implementation of the administrative actions and training that medical professionals in Türkiye should undertake to assist victims who survive smoke exposure, a brief review is also provided of the legal requirements that must be followed in the construction and interior design of buildings where people congregate.
背景:封闭空间火灾中的大多数死亡是由于吸入环境中的一氧化碳、氰化氢和其他气体造成的。材料和方法:本研究回顾性分析了42份室内火灾中死亡的法医尸检报告和相关的犯罪现场报告。尸检分别于2022年和2023年在法医学研究所太平间部进行。结果:42例患者中有33.3%未进行氰化物分析,28例要求血液氰化物分析的患者中检出氰化物的仅为10.7%。虽然76.2%的病例HbCO值超过10%,但所有病例的碳氧血红蛋白水平均为阳性。超过一半的死亡发生在现场,主要是在受害者的家中。所有病例均有烧伤,烧伤程度从二度到炭化程度不等,77.7%的患者上呼吸道和下呼吸道有烟尘污染。对在救护车或医院接受治疗的受害者的血液进行的毒理学分析显示,没有服用解毒剂的证据。结论:本研究的发现强调了从火灾现场死者身上采集血液样本、在暴露于烟雾后立即静脉注射氰化物解毒剂以及由于氰化物半衰期短而对幸存者进行代谢物检测的重要性。为了防止氰化物中毒,并执行 rkiye医务专业人员应采取的行政行动和培训,以帮助在烟雾暴露中幸存的受害者,还简要审查了在人们聚集的建筑物的建造和室内设计中必须遵守的法律要求。
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引用次数: 0
A post-mortem audit of the prevalence of ketoacidosis in diabetes and alcohol dependency 糖尿病和酒精依赖中酮症酸中毒流行的尸检审计
IF 1.2 4区 医学 Q3 MEDICINE, LEGAL Pub Date : 2026-02-01 Epub Date: 2026-02-10 DOI: 10.1016/j.jflm.2026.103088
Peter Vanezis , Rebecca Andrews , Limon Nahar , Ganesh Raj Selvaraja , Andrew Vanezis

Introduction

Ketoacidosis is a form of metabolic acidosis caused by the excess production of ketone bodies. It can be commonly found in the context of both diabetes mellitus and alcohol dependency but is also associated with a myriad other aetiologies. To date the extent of risk of developing ketoacidosis is unclear in diabetic persons who are alcohol dependent and/or have abused alcohol acutely as in ‘binge drinking’.

Methodology

We performed a retrospective analysis of consecutive coroners' autopsies between 2015 and 2023 in a London Coroner's jurisdiction of individuals aged 18 years and above to assess whether significant ketoacidosis, when present, was of diabetic or alcoholic aetiology or a combination of both. Data was obtained from the medical history, circumstances of death, histology, toxicology and biochemical markers. The deceased individuals were surveyed and categorised into the following three groups: 1. Individuals with diabetes mellitus type 1or 2 and with no known history of alcohol dependency according to their medical history; 2. Alcohol dependent persons or persons abusing alcohol acutely, without diabetes mellitus; 3. Diabetic individuals with known alcohol dependency or acute abuse as in ‘binge drinking’. Individuals suffering from other causes of ketoacidosis were excluded.

Results

From an overall total of 3873 autopsies performed of persons 18 years or above over a 9-year period (2015-2023), 1021 cases were analysed and divided into three groups as stated above. Group 1 consisted of 635 diabetic individuals, with ketoacidosis present in 23 (3.6%). Group 2 consisted of 333 individuals with alcohol dependency, in which ketoacidosis was present in 17 (5.1%). Group 3 consisted of 56 individuals, with both diabetes and alcohol dependency, in which ketoacidosis was present in 7 (13%).

Conclusions

This study demonstrated a statistically significant risk of developing ketoacidosis in all individuals with both diabetes mellitus and alcohol dependency (Group 3) when compared to diabetics alone (Group 1): Risk ratio = 3.8; p = .0001). There was less but significant increased risk when females alone were compared in these two groups. Less but significant increased risk was also found in all Group 3 individuals when compared to those in the alcohol alone category (Group 2) or when all individuals or males alone were compared between Group 1 + Group 2 with those in (Group 3). There was no significant increased risk when diabetics in Group 1 were compared to persons with alcohol dependency in Group 2.
酮症酸中毒是一种由酮体过量产生引起的代谢性酸中毒。它可以在糖尿病和酒精依赖中普遍发现,但也与无数其他病因有关。迄今为止,酒精依赖和/或急性酗酒的糖尿病患者发生酮症酸中毒的风险程度尚不清楚。方法:我们对2015年至2023年伦敦验尸官辖区内18岁及以上的连续验尸官尸检进行回顾性分析,以评估是否存在明显的酮症酸中毒,如果存在,是糖尿病或酒精原因,还是两者兼有。数据来自病史、死亡情况、组织学、毒理学和生化指标。对死者进行了调查,并将其分为以下三组:1型或2型糖尿病患者,根据其病史没有已知的酒精依赖史;2. 酒精依赖者或急性酒精滥用者,无糖尿病;3. 糖尿病患者,已知酒精依赖或急性滥用,如“酗酒”。患有其他原因酮症酸中毒的个体被排除在外。结果2015-2023年9年间,共对3873例18岁及以上人群进行尸检,其中1021例进行分析,并按上述方法分为三组。1组635例糖尿病患者,其中23例(3.6%)出现酮症酸中毒。第2组333人有酒精依赖,其中17人(5.1%)出现酮症酸中毒。第3组包括56例糖尿病和酒精依赖患者,其中7例(13%)出现酮症酸中毒。本研究表明,与单独的糖尿病患者(1组)相比,所有糖尿病和酒精依赖患者(3组)发生酮症酸中毒的风险具有统计学意义:风险比= 3.8;p = 0.0001)。在这两组中,仅女性患病的风险增加较少,但却显著增加。与单独饮酒组(第2组)相比,第3组的所有个体或男性与第1组+第2组的个体或男性与第3组的个体相比,风险增加幅度较小,但也有显著增加。第1组的糖尿病患者与第2组的酒精依赖患者相比,风险没有显著增加。
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引用次数: 0
Post-mortem CT scan reveals sequential self-inflicted gunshot wounds to the head: Initial non-lethal followed by fatal injury 死后的CT扫描显示头部有连续的自残枪伤:最初的非致命伤,随后是致命伤
IF 1.2 4区 医学 Q3 MEDICINE, LEGAL Pub Date : 2026-02-01 Epub Date: 2026-02-11 DOI: 10.1016/j.jflm.2026.103092
Sylvain Grange , Carolyne Bidat-Callet , Elodie Hattat , Claire Boutet , Natalia Gorelik

Introduction

Post-mortem imaging plays a crucial role in forensic investigations. While self-inflicted gunshot wounds to the head are common, cases involving multiple shots, especially with a clear sequential pattern, are extremely rare.

Case presentation

We report the case of an 82-year-old man found deceased by his wife, seated in a chair with a 9mm firearm on his lap. Two ejected shell casings were found nearby. No signs of struggle or forced entry were noted. The decedent had a known history of metastatic prostate cancer and had previously expressed suicidal ideation.

Technique and imaging findings

Post-mortem CT-scan (PMCT) allowed precise visualization of entrance and exit wounds, fractures, bullet paths, and hemorrhagic patterns. The fractures from the second shot stopped against the fractures from the first shot, revealing the direction and chronology of the injuries: a non-lethal submental gunshot followed by a fatal right temporal shot.

Discussion

This case highlights the forensic value of PMCT in determining the chronological order of gunshot wounds. The imaging confirmed the cause of death and established the sequence of injuries, crucial for medico-legal investigations.

Conclusion

PMCT provides non-invasive, high-resolution insights into bone trauma. In cases of multiple self-inflicted gunshots, it can help establish the precise chronology of injuries, supporting forensic analysis.
尸检成像在法医调查中起着至关重要的作用。虽然头部自伤的枪伤很常见,但涉及多次射击的案件,尤其是有明显连续模式的案件,是极其罕见的。我们报告一名82岁的男子被他的妻子发现死亡,他坐在椅子上,腿上放着一把9毫米的枪。在附近发现了两个弹壳。没有发现挣扎或强行进入的痕迹。死者有已知的转移性前列腺癌病史,并曾表达过自杀意念。技术和成像发现:死后ct扫描(PMCT)可以精确地观察进出伤口、骨折、子弹路径和出血模式。第二枪的骨折与第一枪的骨折相吻合,显示了伤口的方向和时间顺序一颗非致命的颏下枪伤之后是一颗致命的右颞部枪伤。本案例突出了PMCT在确定枪伤时间顺序方面的法医价值。图像确认了死因并确定了受伤顺序,这对法医调查至关重要。结论pmct可提供无创、高分辨率的骨外伤诊断。在多起自己造成的枪击事件中,它可以帮助建立准确的受伤时间,支持法医分析。
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引用次数: 0
Effects of clonazepam on developmental stages of Calliphora vicina Robineau-Desvoidy 1830 (Diptera: Calliphoridae) and its implications for PMI estimation 氯硝西泮对小栉蝇1830(双翅目:栉蝇科)发育阶段的影响及其对PMI估算的意义。
IF 1.2 4区 医学 Q3 MEDICINE, LEGAL Pub Date : 2026-02-01 Epub Date: 2026-02-10 DOI: 10.1016/j.jflm.2026.103093
Bahriye Ayaz , Ferhat Altunsoy
Clonazepam (Rivotril®) is among the most widely prescribed benzodiazepines. However, its non-therapeutic use carries a substantial risk of misuse, dependence, and fatal overdose. The presence of such substances in tissues has the potential to complicate post-mortem interval (PMI) estimations in forensic entomology by altering insect growth rates. The present study investigated the effects of clonazepam on the developmental duration, larval weight and length of Calliphora vicina Robineau-Desvoidy 1830 (Diptera: Calliphoridae) under controlled laboratory conditions. Larvae were reared on bovine lung tissues treated with varying concentrations of clonazepam, and developmental duration, larval weight, and length were systematically recorded until adult emergence. The results demonstrated that Clonazepam exposure produced significant, concentration-dependent alterations in development. At the highest concentration tested, larval development was prolonged by 40 h, with a total developmental delay of up to 64 h compared with the control group. Furthermore, larval weight and length were significantly reduced, with developmental responses varying across larval, pupal, and post-feeding stages. Notably, this study reveals for the first time that clonazepam significantly delays the developmental stages of C. vicina. These findings underscore the necessity of correcting PMI estimates in cases of benzodiazepine intoxication, as ignoring this delay could lead to an underestimation of the time since death.
氯硝西泮(Rivotril®)是处方最广泛的苯二氮卓类药物之一。然而,它的非治疗性使用有误用、依赖和致命过量的巨大风险。这些物质在组织中的存在有可能通过改变昆虫的生长速率使法医昆虫学的死后间隔(PMI)估计复杂化。在实验室控制条件下,研究了氯硝西泮对姬蝇1830 (Calliphora vicina Robineau-Desvoidy 1830)发育时间、幼虫体重和体长的影响。用不同浓度氯硝西泮处理过的牛肺组织饲养幼虫,系统记录幼虫的发育时间、体重和体长,直到成虫羽化。结果表明氯硝西泮暴露在发育过程中产生了显著的浓度依赖性改变。在最高浓度下,与对照组相比,幼虫发育延迟40 h,总发育延迟达64 h。此外,幼虫的体重和长度显著减少,在幼虫期、蛹期和摄食后的发育反应不同。值得注意的是,这项研究首次揭示了氯硝西泮显着延缓了C. vicina的发育阶段。这些发现强调了在苯二氮卓类药物中毒病例中纠正PMI估计的必要性,因为忽略这种延迟可能导致对死亡时间的低估。
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引用次数: 0
Physician awareness of the ICD-10 coding system for assigning the cause of death in primary health centers in Muscat and South Batinah governorates, Oman 阿曼马斯喀特省和南巴蒂纳省初级卫生中心的医生对ICD-10死因分配编码系统的认识。
IF 1.2 4区 医学 Q3 MEDICINE, LEGAL Pub Date : 2026-02-01 Epub Date: 2026-01-08 DOI: 10.1016/j.jflm.2026.103072
Omar Al Farsi , Raniya Al Kiyumi , Akram Al Adawi , Faiz Al Harmali

Background

Accurate mortality statistics are vital for establishing health policies. However, reporting numerous undetermined causes of death especially in the primary healthcare hinder the accuracy and usefulness of vital statistics, impacting resource allocation for disease prevention and control. Utilizing International Classification of Diseases (ICD-10) coding systems and addressing physician-related challenges are essential to improve the quality of mortality data and support effective policymaking. Therefore, this study aims to assess physicians' awareness in assigning accurate causes of death at the primary healthcare institutions.

Methods

A cross-sectional study conducted with 202 physicians from the primary health care institutions in Muscat and South Batinah governorates. A convenience sampling method has been used to distribute self-administered questionnaire.

Results

The findings indicated that a higher proportion of physicians were familiar with the ICD-10 coding and World Health Organization (WHO) guidelines, with (41.9 %) of non-Omani physicians demonstrating awareness, compared to (22 %) of Omani physicians. Both groups showed limited knowledge about the use of garbage codes, with a notable proportion unaware of their implications. Additionally, challenges in determining the underlying cause of death (UCOD) were reported, with (48.6 %) Omani physicians facing difficulties, compared to (40.9 %) of the other group. Training gaps and lack of feedback from the Ministry of Health (MoH) were identified as contributing factors affecting both groups.

Conclusion

The findings highlight key implications for policy and practice in coding mortality data. Ongoing awareness programs for physicians on ICD-10 coding system are essential, and establishing structured feedback channels with the MoH is crucial to improve data quality.
背景:准确的死亡率统计对制定卫生政策至关重要。然而,报告许多未确定的死亡原因,特别是在初级保健中,妨碍了生命统计的准确性和有用性,影响了用于疾病预防和控制的资源分配。利用国际疾病分类(ICD-10)编码系统和解决与医生相关的挑战对于提高死亡率数据的质量和支持有效的政策制定至关重要。因此,本研究旨在评估医师在初级卫生保健机构中分配准确死因的意识。方法:对来自马斯喀特省和南巴蒂纳省初级卫生保健机构的202名医生进行横断面研究。采用方便抽样法发放自填问卷。结果:调查结果表明,熟悉ICD-10编码和世界卫生组织(WHO)指南的医生比例较高,非阿曼医生的比例为41.9%,而阿曼医生的比例为22%。两组人都对垃圾代码的使用了解有限,有相当一部分人不知道它们的含义。此外,据报告,在确定潜在死亡原因(UCOD)方面存在挑战,(48.6%)阿曼医生面临困难,而其他组的这一比例为(40.9%)。培训差距和缺乏卫生部的反馈被确定为影响这两个群体的因素。结论:研究结果突出了对死亡率数据编码的政策和实践的关键意义。开展医生对ICD-10编码系统的认识项目至关重要,与卫生部建立结构化反馈渠道对于提高数据质量至关重要。
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引用次数: 0
Forensic diatomology of Pong dam reservoir: Implications for drowning diagnosis and site identification Pong坝水库法医病理学:对溺水诊断和地点鉴定的意义
IF 1.2 4区 医学 Q3 MEDICINE, LEGAL Pub Date : 2026-02-01 Epub Date: 2026-02-11 DOI: 10.1016/j.jflm.2026.103094
Ajay Singh Rana , Priyanka Verma , Meenakshi Mahajan
Determining antemortem drowning in medico-legal casework remains a persistent forensic challenge, particularly in bodies exhibiting advanced putrefactive changes, where conventional morphological indicators are no longer discernible. Forensic diatomology provides a critical microtrace-evidence framework for substantiating drowning and enabling immersion-site attribution through ecological fingerprinting of diatom assemblages. Despite the frequent retrieval of suspected drowning victims from the Pong Dam reservoir hydrologically influenced by the Beas river no comprehensive spatiotemporal diatom baseline exists to support comparative forensic analyses.
In this study, high-resolution limnological profiling and detailed morphotaxonomic diatom characterization were undertaken across five sampling stations and six seasonal intervals. A total of 113 taxa were identified using light microscopy and standardized diatom preparation protocols. Canonical Correspondence Analysis (CCA) demonstrated statistically robust relationships between diatom community composition, hydroclimatic seasonality, and key physicochemical drivers. The reservoir exhibited pronounced assemblage homogenization, reflecting dominance by environmentally tolerant euryhaline and eurythermal taxa with high dispersal potential.
This investigation provides the first spatially resolved, seasonally stratified diatom reference dataset for Pong Dam, delineating site-specific and season-responsive indicator taxa with demonstrable forensic utility. The dataset significantly strengthens diatomological comparison in drowning cases, particularly when postmortem intervals encompass multiple seasonal transitions. These findings enhance diagnostic reliability in immersion-site reconstruction and reinforce the evidentiary value of diatom microtraces in complex medico-legal drowning determinations.
在法医案件中,确定死前溺水仍然是一项持续的法医挑战,特别是在表现出晚期腐烂变化的尸体上,传统的形态学指标已无法辨认。法医硅藻学提供了一个关键的微迹证据框架,通过硅藻组合的生态指纹,证实溺水和使浸入式现场归因成为可能。尽管经常从受Beas河水文影响的Pong坝水库中检索疑似溺水受害者,但没有全面的时空硅藻基线来支持比较法医分析。在这项研究中,在五个采样站和六个季节间隔进行了高分辨率的湖泊分析和详细的形态分类硅藻表征。采用光镜和标准化硅藻制备方案共鉴定了113个分类群。典型对应分析(CCA)表明,硅藻群落组成、水文气候季节性和关键物理化学驱动因素之间存在统计学上的密切关系。储层具有明显的组合均一性,以环境耐受的泛盐和泛热类为主,具有较高的扩散潜力。该研究为Pong Dam提供了第一个空间分辨的、季节分层的硅藻参考数据集,描绘了特定地点和季节响应的指示分类群,具有可证明的法医效用。该数据集显著加强了溺水病例的硅藻学比较,特别是当尸检间隔包含多个季节转换时。这些发现提高了浸入式现场重建诊断的可靠性,并加强了硅藻微迹在复杂的医学-法律溺水测定中的证据价值。
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引用次数: 0
Cardiac Safety of Conducted Energy Devices: Electrophysiological mechanisms, risk assessment, and forensic interpretation 传导能量装置的心脏安全性:电生理机制、风险评估和法医解释
IF 1.2 4区 医学 Q3 MEDICINE, LEGAL Pub Date : 2026-02-01 Epub Date: 2026-01-21 DOI: 10.1016/j.jflm.2026.103082
Charles D. Deakin

Background

Conducted Energy Devices (CEDs) or Conducted Energy Weapons (CEWs), among which the best known are the TASER® brand, are increasingly deployed by law-enforcement agencies. Their established cardiac safety is overshadowed by temporally-associated sudden deaths, which are often directly attributed to CED discharge. Concern remains that in rare cases, high-voltage CED pulses might directly induce fatal cardiac arrhythmias.

Methods

This review considers electrophysiological evidence, computational modelling, and forensic case data to understand the mechanisms governing cardiac stimulation during CED exposure. It discusses strength–duration relationships, differential excitement of neuromuscular and myocardial tissues, and compares predicted electrical stimulation thresholds with those determined by finite element modelling. This evidence is compared with clinical evidence of CED-induced malignant arrythmias.

Findings

CED pulses of 50–100 μs are both too brief and too weak to depolarise cardiac myocytes under normal anatomical conditions. Finite-element and finite-integration models show typical myocardial current densities of 0.27–0.6 mA cm−2 which are more than two orders of magnitude below the short-pulse VF threshold of ∼100–150 mA cm−2 (≈4 mA cm−2 RMS). Layered thoracic modelling demonstrates that muscle anisotropy and chest-wall thickness diverts almost 90 % of current laterally, producing cardiac field strengths far beneath depolarisation levels. Rare trans-cardiac probe alignments or thin chest walls, however, may approach capture thresholds and therefore cannot be considered completely risk-free.

Conclusions

Current evidence indicates that in all but extreme probe geometries or paediatric exposures, CED are at minimal risk of inducing malignant arrhythmias. Forensic assessment of CED-related deaths should consider electrophysiological principles with probe placement, the timing of the collapse, and toxicological findings in order to distinguish coincidental from causally related events.
背景传导能量装置(ced)或传导能量武器(CEWs),其中最著名的是泰瑟®品牌,越来越多地被执法机构部署。他们建立的心脏安全性被暂时性猝死所掩盖,后者通常直接归因于CED出院。在极少数情况下,高压CED脉冲可能直接诱发致命性心律失常。方法本综述考虑了电生理证据、计算模型和法医案例数据,以了解在CED暴露期间控制心脏刺激的机制。它讨论了强度-持续时间的关系,神经肌肉和心肌组织的不同兴奋,并将预测的电刺激阈值与有限元模型确定的阈值进行了比较。这一证据与ced诱发的恶性心律失常的临床证据进行了比较。发现在正常解剖条件下,50-100 μs的sced脉冲既短又弱,无法使心肌细胞去极化。有限元和有限积分模型显示,典型的心肌电流密度为0.27-0.6 mA cm - 2,比短脉冲VF阈值约100-150 mA cm - 2 (RMS≈4 mA cm - 2)低两个数量级以上。分层胸腔模型表明,肌肉各向异性和胸壁厚度将近90%的电流侧向转移,产生远低于去极化水平的心脏场强度。然而,罕见的经心探头排列或胸壁薄可能接近捕获阈值,因此不能认为完全没有风险。结论目前的证据表明,除了极端探头几何形状或儿科暴露外,CED诱发恶性心律失常的风险很小。对ed相关死亡的法医评估应考虑探针放置的电生理学原理、崩溃的时间和毒理学结果,以区分偶然事件和因果相关事件。
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引用次数: 0
Evidence of point-of-care diagnostics in forensic death investigations: A scoping review 法医死亡调查中即时诊断的证据:范围审查
IF 1.2 4区 医学 Q3 MEDICINE, LEGAL Pub Date : 2026-02-01 Epub Date: 2026-01-29 DOI: 10.1016/j.jflm.2026.103086
Sebueng Ramatsokotla , Bathabile Soul , Evans Duah , Letlhogonolo Sekwele , Gabrielle Thompson , Kuhlula Maluleke , Linda Mbonambi , Tivani Mashamba-Thompson

Background

Point-of-care (POC) diagnostics represent promising health-technology tools capable of providing rapid, on-site analytical support for forensic investigations. This scoping review aimed to systematically map the available evidence on applying POC diagnostics in forensic investigations. The focus is on their potential ability to act as rapid screening and triage tools to assist in determining the cause of death and exploring the challenges and opportunities associated with their implementation on a global scale.

Methods

A comprehensive literature search was conducted across multiple databases, including PubMed, ProQuest Central, Academic Search Complete, Africa Wide, CINAHL, MEDLINE, and Web of Science. Out of the 7603 records screened, four studies met the eligibility criteria and were included in the review. Reporting adhered to the PRISMA-ScR guidelines.

Results

These studies demonstrated the expanding role of POC devices in various aspects of forensic investigations, including rapid triage in overdose cases, malaria diagnosis in travel-related deaths, SARS-CoV-2 screening, and hemoglobin testing in child deaths. These studies also highlighted the limitations of POC devices in the postmortem context, emphasizing the need for careful calibration, confirmation, and interpretation of the results. This review identified POC diagnostics as a potential bridge between forensic investigations and public health surveillance, with findings indicating both cause-of-death determination and broader public health strategies. Operational, ethical, and policy considerations for using POC devices in forensic investigations were also discussed.

Conclusion

This review revealed challenges in ensuring the standardization, accuracy, and integration of POC diagnostics into established forensic practices. Further research is required to evaluate the diagnostic accuracy, cost-effectiveness, and performance of POC tools in forensic settings. Comprehensive guidelines and standardized operating procedures should be developed to ensure the successful implementation of POC diagnostics in forensic investigations. Given the limited and heterogeneous evidence, POC devices in forensic death investigations should be seen as preliminary aids rather than diagnostic instruments.
医疗点诊断是有前途的卫生技术工具,能够为法医调查提供快速的现场分析支持。该范围审查旨在系统地绘制在法医调查中应用POC诊断的现有证据。重点是它们作为快速筛查和分类工具的潜在能力,以协助确定死亡原因,并探讨在全球范围内实施这些工具所面临的挑战和机遇。方法在PubMed、ProQuest Central、Academic search Complete、Africa Wide、CINAHL、MEDLINE、Web of Science等数据库中进行综合文献检索。在筛选的7603份记录中,有4项研究符合资格标准,被纳入本综述。报告遵循PRISMA-ScR指南。结果这些研究表明,POC设备在法医调查的各个方面发挥着越来越大的作用,包括药物过量病例的快速分诊、旅行相关死亡的疟疾诊断、SARS-CoV-2筛查和儿童死亡的血红蛋白检测。这些研究还强调了POC装置在死后情况下的局限性,强调需要仔细校准、确认和解释结果。本次审查确定POC诊断是法医调查和公共卫生监测之间的潜在桥梁,其调查结果表明了死因确定和更广泛的公共卫生战略。还讨论了在法医调查中使用POC设备的操作、道德和政策方面的考虑。结论本综述揭示了在确保POC诊断的标准化、准确性和整合到现有法医实践中的挑战。需要进一步的研究来评估法医环境中POC工具的诊断准确性、成本效益和性能。应制定全面的指导方针和标准化的操作程序,以确保在法医调查中成功实施POC诊断。鉴于证据有限且种类繁多,法医死亡调查中的POC装置应被视为初步辅助工具,而不是诊断工具。
{"title":"Evidence of point-of-care diagnostics in forensic death investigations: A scoping review","authors":"Sebueng Ramatsokotla ,&nbsp;Bathabile Soul ,&nbsp;Evans Duah ,&nbsp;Letlhogonolo Sekwele ,&nbsp;Gabrielle Thompson ,&nbsp;Kuhlula Maluleke ,&nbsp;Linda Mbonambi ,&nbsp;Tivani Mashamba-Thompson","doi":"10.1016/j.jflm.2026.103086","DOIUrl":"10.1016/j.jflm.2026.103086","url":null,"abstract":"<div><h3>Background</h3><div>Point-of-care (POC) diagnostics represent promising health-technology tools capable of providing rapid, on-site analytical support for forensic investigations. This scoping review aimed to systematically map the available evidence on applying POC diagnostics in forensic investigations. The focus is on their potential ability to act as rapid screening and triage tools to assist in determining the cause of death and exploring the challenges and opportunities associated with their implementation on a global scale.</div></div><div><h3>Methods</h3><div>A comprehensive literature search was conducted across multiple databases, including PubMed, ProQuest Central, Academic Search Complete, Africa Wide, CINAHL, MEDLINE, and Web of Science. Out of the 7603 records screened, four studies met the eligibility criteria and were included in the review. Reporting adhered to the PRISMA-ScR guidelines.</div></div><div><h3>Results</h3><div>These studies demonstrated the expanding role of POC devices in various aspects of forensic investigations, including rapid triage in overdose cases, malaria diagnosis in travel-related deaths, SARS-CoV-2 screening, and hemoglobin testing in child deaths. These studies also highlighted the limitations of POC devices in the postmortem context, emphasizing the need for careful calibration, confirmation, and interpretation of the results. This review identified POC diagnostics as a potential bridge between forensic investigations and public health surveillance, with findings indicating both cause-of-death determination and broader public health strategies. Operational, ethical, and policy considerations for using POC devices in forensic investigations were also discussed.</div></div><div><h3>Conclusion</h3><div>This review revealed challenges in ensuring the standardization, accuracy, and integration of POC diagnostics into established forensic practices. Further research is required to evaluate the diagnostic accuracy, cost-effectiveness, and performance of POC tools in forensic settings. Comprehensive guidelines and standardized operating procedures should be developed to ensure the successful implementation of POC diagnostics in forensic investigations. Given the limited and heterogeneous evidence, POC devices in forensic death investigations should be seen as preliminary aids rather than diagnostic instruments.</div></div>","PeriodicalId":16098,"journal":{"name":"Journal of forensic and legal medicine","volume":"118 ","pages":"Article 103086"},"PeriodicalIF":1.2,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146078233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Professional judgement in Forensic & Legal Medicine (FLM) 法医与法医学的职业判断
IF 1.2 4区 医学 Q3 MEDICINE, LEGAL Pub Date : 2026-02-01 Epub Date: 2026-01-21 DOI: 10.1016/j.jflm.2026.103084
Margaret Stark , Bernadette Butler , Michael Devlin , Alex Gorton
Professional judgement in forensic & legal medicine (FLM) refers to the ability of healthcare professionals (HCPs) to use their knowledge, experience, and critical thinking skills to make informed decisions about patient care, often in complex or ambiguous situations.
Clinicians must keep patients the focus of any assessment and HCPs need to use professional judgement when interpreting Guidelines and/or Recommendations and when there is a clear and justifiable requirement to deviate from a Standard Operating Procedure because of patient need. Only with training and supervision by expert educators will quality standards be maintained with a workforce that is skilled in using professional judgement.
法医和法律医学(FLM)中的专业判断是指医疗保健专业人员(HCPs)利用他们的知识、经验和批判性思维技能,通常在复杂或模棱两可的情况下,对患者护理做出明智决策的能力。临床医生必须将患者作为任何评估的焦点,医务人员在解释指南和/或建议时,以及由于患者的需要而有明确和合理的要求偏离标准操作程序时,需要进行专业判断。只有在专业教育工作者的培训和监督下,才能用一支熟练运用专业判断的劳动力队伍来维持质量标准。
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引用次数: 0
期刊
Journal of forensic and legal medicine
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