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Can human sex be estimated based on the dimensions of the maxillary sinuses? A systematic review of the literature on cone-beam and multi-slice computed tomography 能否根据上颌窦的尺寸估计人类性别?对锥形束和多层计算机断层扫描文献的系统回顾。
IF 1.2 4区 医学 Q3 MEDICINE, LEGAL Pub Date : 2024-07-01 DOI: 10.1016/j.jflm.2024.102716
Matheus Sampaio-Oliveira , Larissa de Oliveira Reis , Lucas P. Lopes Rosado , Marcela Baraúna Magno , Lucianne Cople Maia , Matheus L. Oliveira

Purpose

To critically appraise and summarize the potential of linear and/or volumetric dimensions of the maxillary sinuses obtained with cone-beam and multi-slice computed tomography.

Methods

A bibliographic search was conducted in seven databases in August 2023. Cross-sectional retrospective studies using linear and volumetric measurements of the maxillary sinuses obtained with cone-beam and multi-slice computed tomography for sex estimation and presenting numerical estimation data were included. Narrative or systematic reviews, letters to the editor, case reports, laboratory studies in animals, and experimental studies were excluded. The critical appraisal and certainty of evidence were assessed using the guidelines described by Fowkes and Fulton and GRADE, respectively.

Results

A total of 656 studies were found, 32 of which were included. A total of 3631 individuals were analyzed and the overall sex estimation rate ranged from 54.9 % to 95 %. When compared with isolated measurements, combined linear measurements of the right and left maxillary sinuses, such as width, length, and height, provided a higher rate of sex estimation (54.9–95 %). In most of the studies (62.5 %), all measurements were higher in men than in women. Multiple methodological problems were found in the studies, especially distorting influences in 84.4 % of the answers. The certainty of evidence varied from very low to low.

Conclusions

The combination of height, width, and length measurements of the right and left maxillary sinuses from cone-beam and multi-slice computed tomography can be useful in the estimation of sex of humans. Further primary studies are needed to increase the certainty of evidence.

Prospero register

CRD42020161922.

目的:对锥形束和多切片计算机断层扫描获得的上颌窦线性和/或容积尺寸的潜力进行批判性评估和总结:方法:2023 年 8 月在七个数据库中进行了文献检索。方法:于 2023 年 8 月在 7 个数据库中进行了文献检索,纳入了使用锥形束和多切片计算机断层扫描获得的上颌窦线性和容积测量值进行性别估计并提供数值估计数据的横断面回顾性研究。叙事性或系统性综述、致编辑的信、病例报告、动物实验室研究和实验研究除外。分别采用 Fowkes 和 Fulton 以及 GRADE 所描述的指南对证据的批判性评价和确定性进行评估:结果:共发现 656 项研究,其中 32 项被纳入。共分析了 3631 人,总体性别估计率从 54.9% 到 95% 不等。与单独测量相比,对左右上颌窦的宽度、长度和高度等综合线性测量的性别估计率更高(54.9%-95%)。在大多数研究中(62.5%),男性的所有测量值均高于女性。研究中发现了多种方法问题,尤其是 84.4% 的答案存在扭曲影响。证据的确定性从很低到很低不等:结论:通过锥形束和多切片计算机断层扫描对左右上颌窦的高度、宽度和长度进行综合测量,有助于对人体性别进行估计。要提高证据的确定性,还需要进一步的初步研究:CRD42020161922。
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引用次数: 0
Alcimedes 阿基米德
IF 1.2 4区 医学 Q3 MEDICINE, LEGAL Pub Date : 2024-07-01 DOI: 10.1016/j.jflm.2024.102714
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引用次数: 0
Necrotizing Fasciitis: When skin confuses - An autopsy case report 坏死性筋膜炎:皮肤混淆--尸检病例报告
IF 1.2 4区 医学 Q3 MEDICINE, LEGAL Pub Date : 2024-07-01 DOI: 10.1016/j.jflm.2024.102715
Renjini Johnson, Fathima Harsha P.M, Anup Kumar Raipuria, Sangeeta Kumari, Shiuli

Necrotizing Fasciitis (NF) is a severe life-threatening soft tissue infection characterized by the rapid destruction of muscle, fat and fascial layers. This report details an autopsy case report of a 40year old male, unclaimed body lacking the complete history except that given by the Police personnel accompanying in which there is no prior history of trauma. This person succumbed to septic shock secondary to NF, despite clinical interventions. This case emphasizes the importance of early diagnosis and the need for heightened clinical awareness to improve patient outcomes.

坏死性筋膜炎(NF)是一种严重威胁生命的软组织感染,其特点是肌肉、脂肪和筋膜层迅速遭到破坏。本报告详细介绍了一具 40 岁男性尸体的尸检报告,该尸体无人认领,除警方人员提供的病史外,没有其他完整病史,也没有外伤史。尽管采取了临床干预措施,但此人仍因继发于 NF 的脓毒性休克而死亡。该病例强调了早期诊断的重要性以及提高临床意识以改善患者预后的必要性。
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引用次数: 0
A comprehensive review on application of atomic force microscopy in Forensic science 原子力显微镜在法医学中的应用综述
IF 1.2 4区 医学 Q3 MEDICINE, LEGAL Pub Date : 2024-07-01 DOI: 10.1016/j.jflm.2024.102717
Megha Therassa, N.S. Aparna, Maria Jose, Ajil Dev, Arjun Rao Isukapatla

The primary objective of forensic investigation of a case is to recognize, identify, locate, and examine the evidence. Microscopy is a technique that provides crucial information for resolving a case or advancing the investigation process by analyzing the evidence obtained from a crime scene. It is often used in conjunction with suitable analytical techniques. Various microscopes are employed; scanning probe microscopes are available in diverse forensic analyses and studies. Among these, the atomic force microscope (AFM) is the most commonly used scanning probe technology, offering a unique morphological and physico-chemical perspective for analyzing multiple pieces of evidence in forensic investigations. Notably, it is a non-destructive technique capable of operating in liquid or air without complex sample preparation. The article delves into a detailed exploration of the applications of AFM in the realms of nanomechanical forensics and nanoscale characterization of forensically significant samples.

对案件进行法证调查的主要目的是识别、鉴定、查找和检查证据。显微镜技术是一种通过分析从犯罪现场获得的证据为破案或推进调查过程提供关键信息的技术。它通常与适当的分析技术结合使用。使用的显微镜多种多样;扫描探针显微镜可用于各种法医分析和研究。其中,原子力显微镜(AFM)是最常用的扫描探针技术,可提供独特的形态和物理化学视角,用于分析法医调查中的多种证据。值得注意的是,它是一种非破坏性技术,能够在液体或空气中操作,无需复杂的样品制备。文章详细探讨了原子力显微镜在纳米机械取证和具有重要取证意义样本的纳米级表征领域的应用。
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引用次数: 0
A method of identifying the high-risk mutations of sudden cardiac death at KCNQ1 and KCNH2 genes 一种识别 KCNQ1 和 KCNH2 基因心源性猝死高危突变的方法
IF 1.2 4区 医学 Q1 Social Sciences Pub Date : 2024-06-15 DOI: 10.1016/j.jflm.2024.102707
Jiaqi Wang , Zidong Liu , Yuxin Zhang , Mingming Zhang , Deqing Chen , Gengqian Zhang

Sudden Cardiac Death (SCD) often shows negative anatomy results after a systemic autopsy and the gene mutations of potassium channel play a key role in the etiology of SCD. We established a feasible system to detect SCD-related mutations and investigated the mutations at KCNQ1 and KCNH2 genes in the Chinese population. We established a mutation detection system combined with multiplex PCR, SNaPshot technique, and capillary electrophoresis. We genotyped 101 putative mutations at KCNQ1 and KCNH2 genes in 60 SCD of negative anatomy and 50 controls using the established assay and compared Odd Ratio (OR). Four coding variants were identified in the KCNQ1 gene: S546S, I145I, P448R, and G643S. The mutations of I145I and S546S did not differ significantly in the SCD compared with controls. 21 SCD individuals (35 %) and 1 control individual (2 %) showed a genotype of C/G at P448R (OR = 17.5, 95 % CI [2.40–127.82]). 24 SCD individuals (40 %) and 1 control individual (2 %) showed a genotype of C/G at G643S (OR = 20.0, 95 % CI [2.75–145.25]). We established a robust assay for rapid screening the putative SCD-related mutations in KCNQ1 and KCNH2 genes. The new assay in our study is easily amenable to the majority of laboratories without the need for new specialized equipment. Our method will meet the increasing requirement of mutation screening for SCD in regular DNA laboratories and will help screen mutations in those dead of SCD and their relatives.

心脏性猝死(SCD)往往在系统尸检后出现阴性解剖结果,而钾通道基因突变在SCD的病因中起着关键作用。我们建立了一套可行的系统来检测与 SCD 相关的基因突变,并调查了中国人群中 KCNQ1 和 KCNH2 基因的突变情况。我们建立了一套结合多重 PCR、SNaPshot 技术和毛细管电泳的突变检测系统。我们使用建立的检测方法对 60 例阴性解剖的 SCD 和 50 例对照的 101 个 KCNQ1 和 KCNH2 基因的推测突变进行了基因分型,并比较了奇异比(OR)。在 KCNQ1 基因中发现了四种编码变异:S546S、I145I、P448R 和 G643S。与对照组相比,SCD 患者的 I145I 和 S546S 基因突变没有显著差异。21 名 SCD 患者(35%)和 1 名对照组患者(2%)的 P448R 基因型为 C/G(OR = 17.5,95% CI [2.40-127.82])。24 名 SCD 患者(40%)和 1 名对照组患者(2%)的基因型为 G643S 的 C/G(OR = 20.0,95 % CI [2.75-145.25])。我们建立了一种稳健的检测方法,用于快速筛查 KCNQ1 和 KCNH2 基因中可能与 SCD 相关的突变。我们研究中的新检测方法很容易适用于大多数实验室,无需新的专业设备。我们的方法将满足常规 DNA 实验室对 SCD 基因突变筛查日益增长的需求,并有助于筛查 SCD 死者及其亲属的基因突变。
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引用次数: 0
Hunger strikes and force feeding in detention: Clinical and ethical challenges 绝食和强制喂食:临床和伦理挑战
IF 1.5 4区 医学 Q1 Social Sciences Pub Date : 2024-06-10 DOI: 10.1016/j.jflm.2024.102706
Fabiola Molina , Sumaiya Sayeed , John J. Andrews , Katherine C. McKenzie
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引用次数: 0
Sexual dimorphism of the twelfth thoracic vertebra for sex determination in the Central Thai population 泰国中部人群第十二胸椎的性别二形性,用于性别鉴定
IF 1.5 4区 医学 Q1 Social Sciences Pub Date : 2024-05-01 DOI: 10.1016/j.jflm.2024.102688
Paleenan Srithawee , Duangnate Pipatsatitpong , Narumol Parasompong , Nutcha Poolkasem , Palita Watthanaworasakul , Pairoa Praihirunkit

Analyzing skeletal remains is crucial for identifying individuals, and forensic anthropologists use this analysis to determine biological characteristics, particularly sex, aiding criminal investigations. Among thoracic vertebrae, the twelfth thoracic vertebra (T12) is highly sexually dimorphic in various populations. This study aims to establish a discriminant function equation (DFE) for sex determination based on T12 in the Central Thai population. A total of 15 parameters of T12 were examined in 69 bone samples (43 males and 26 females). Among the 15 parameters, 14 were significantly different between males and females. The discriminant function equation (DFE) was generated as DFE = −19.578 + 0.376(i) BDsm + 0.254(l) PW + 0.081TDm, with a cutoff value of −0.296 for males and females, showing 92.8 % accuracy. The evaluation of the DFE using 10 blind samples showed 90 % accuracy. These findings may offer an additional method for sex determination through T12, complementing the examination of other skeletal elements.

分析骨骼遗骸对识别个人身份至关重要,法医人类学家利用这种分析来确定生物特征,特别是性别,从而帮助刑事调查。在胸椎中,第十二胸椎(T12)在不同人群中具有高度的性别二态性。本研究旨在建立一个基于泰国中部人群 T12 的性别判定判别函数方程(DFE)。共对 69 个骨骼样本(43 个男性样本和 26 个女性样本)的 15 个 T12 参数进行了检测。在这 15 个参数中,有 14 个参数在男性和女性之间存在显著差异。生成的判别函数方程(DFE)为 DFE = -19.578 + 0.376(i) BDsm + 0.254(l) PW + 0.081TDm,男性和女性的临界值为-0.296,准确率为 92.8%。使用 10 个盲样对 DFE 进行的评估显示,准确率为 90%。这些发现为通过 T12 进行性别鉴定提供了一种新方法,是对其他骨骼元素检查的补充。
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引用次数: 0
Forensic medicine in (West-Bank) Palestine visions and obstacles 巴勒斯坦法医学的愿景与障碍
IF 1.5 4区 医学 Q1 Social Sciences Pub Date : 2024-05-01 DOI: 10.1016/j.jflm.2024.102696
Hafsah Ghanem

Forensic medicine in Palestine is a new branch of medicine compared with other medical specialties and is still at a nascent stage. Only 6 medical doctors specializing in forensic medicine are currently practicing in Palestine, including only one female specialist (the author). Palestine has adopted a system that combines clinical forensic medicine and forensic pathology. Forensic doctors can deal with both the living and the dead and deal with cases of physical and sexual assault, gender-based violence, and domestic violence.

In different courts, such as civil, military, and shariah, Palestinian judicial decisions depend primarily on forensic medical reports and the testimonies that forensic doctors provide for the court to explain their reports. Forensic medicine has a significant role and crucial impact on achieving justice for victims of all types of abuse, either dead or alive. However, the role of forensic medicine in achieving justice for victims, and hence fighting and eradicating violence, is underestimated and not fully understood by the general population.

This paper introduces to the reader the status of forensic medicine in Palestine, focusing on the challenges and obstacles faced by both the victims and forensic doctors. Meeting these challenges and overcoming obstacles is essential for fighting all types of violence, including violence against women in Palestinian society.

The current provision of forensic medical services in Palestine is less than satisfactory, being considerably hampered by the lack of legislation and regulations.

Palestine is in great need of continued international support for forensic medicine and forensic services. Two projects supported by the United Nations put the country on the road, but there are still many miles to go toward the aim.

与其他医学专业相比,巴勒斯坦的法医学是一个新的医学分支,仍处于起步阶段。巴勒斯坦目前只有 6 名法医学专科医生,其中只有一名女性专家(提交人)。巴勒斯坦采用了临床法医学和法医病理学相结合的制度。在民事、军事和伊斯兰教法等不同法庭上,巴勒斯坦的司法判决主要取决于法医报告以及法医为法庭解释其报告而提供的证词。法医在为各类虐待行为的受害者(无论死活)伸张正义方面发挥着重要作用和关键影响。然而,法医学在为受害者伸张正义,进而打击和根除暴力方面的作用却被低估了,也没有得到普通民众的充分理解。本文向读者介绍了巴勒斯坦法医学的现状,重点是受害者和法医面临的挑战和障碍。应对这些挑战和克服障碍对于打击所有类型的暴力行为,包括巴勒斯坦社会中针对妇女的暴力行为至关重要。巴勒斯坦目前提供的法医服务并不令人满意,因为缺乏立法和法规,这在很大程度上阻碍了服务的提供。联合国支持的两个项目使该国走上了正轨,但要实现目标还有很长的路要走。
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引用次数: 0
Bite marks: To opine or not to opine? 咬痕发表意见还是不发表意见?
IF 1.5 4区 医学 Q1 Social Sciences Pub Date : 2024-05-01 DOI: 10.1016/j.jflm.2024.102689
Maria Nittis , Richard Bassed

Much has been written about bite mark comparisons and bite mark analysis. It has largely been written for, and remained within the domain of, the forensic odontologist despite the limited number of such specialists and the even smaller subset who have expertise in this area. For those health professionals who work in the field of clinical forensic medicine, most will not have access to a forensic odontologist. Courts can be reticent about the costs involved in obtaining another expert opinion. For health professionals, who will likely encounter more bite marks in their career than forensic odontologists, the difficulty is knowing what can legitimately be opined about such injuries.

关于咬痕比较和咬痕分析的文章已经很多了。尽管法医牙科专家人数有限,而在这一领域具有专长的专家更是凤毛麟角,但这些文章大多是为法医牙科专家撰写的,而且仍然属于法医牙科专家的范畴。对于那些在临床法医学领域工作的医疗专业人员来说,大多数人都无法接触到法医牙科专家。法院可能会对获取另一位专家意见所涉及的费用讳莫如深。对于保健专业人员来说,他们在职业生涯中遇到的咬痕可能比法医牙科专家更多,困难在于他们不知道对这类伤害可以提出什么合理的意见。
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引用次数: 0
Male rape in Brazil: A descriptive analysis from 2010 to 2022 巴西的男性强奸案:2010 年至 2022 年的描述性分析
IF 1.5 4区 医学 Q1 Social Sciences Pub Date : 2024-05-01 DOI: 10.1016/j.jflm.2024.102684
Edmilson Ozorio dos Santos, Ivan Dieb Miziara

Male rape is a relatively under-discussed topic in scientific literature, despite its significant relevance and prevalence worldwide, including in Brazil. To inform public health and safety policies, this study aimed to analyze cases of male rape using data from SINAN, the Information System for Notifiable Diseases, a division of the Brazilian Ministry of Health, for the years 2010–2022. Our findings reveal a 469 % increase in male rape cases in the country over the study period, with a predominance of cases in the state of São Paulo. Also, a higher prevalence of cases was observed among individuals aged 5–9 years. Furthermore, we identified a correlation between the occurrence of rape and certain factors, including individuals with less than 4 years of formal education if they were over the age of 50, and those who had a history of being sexually abused between the ages of 5 and 14. Additionally, this study reinforces the prevalence of rape cases occurring within domestic environments and perpetrated by individuals closely related to the victims. This study contributes to filling the gap in research on male rape in Brazil, laying the foundation for the development of strategies to prevent and combat rape in the country.

在科学文献中,男性强奸是一个讨论相对较少的话题,尽管它在包括巴西在内的世界范围内具有重要的相关性和普遍性。为了给公共卫生和安全政策提供信息,本研究旨在利用巴西卫生部下属的应报告疾病信息系统 SINAN 中 2010-2022 年的数据分析男性强奸案件。我们的研究结果显示,在研究期间,巴西的男性强奸案件增加了 469%,其中圣保罗州的案件居多。此外,在 5-9 岁的人群中,案件发生率较高。此外,我们还发现强奸案的发生与某些因素有关,包括 50 岁以上正规教育不足 4 年的人,以及在 5 至 14 岁期间有过性虐待史的人。此外,本研究还进一步证实了强奸案件普遍发生在家庭环境中,并且是由与受害者关系密切的人实施的。这项研究有助于填补巴西男性强奸研究方面的空白,为巴西制定预防和打击强奸的战略奠定基础。
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引用次数: 0
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Journal of forensic and legal medicine
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