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The Use of Shape-Memory Alloy Staples (Nitinol) in the Treatment of Pubic Symphyseal Disruptions: Clinical Results and Radiographic Outcomes. 使用形状记忆合金钉(镍钛诺)治疗耻骨联合破裂:临床结果和影像学结果。
Q3 Dentistry Pub Date : 2022-01-01 DOI: 10.1615/JLongTermEffMedImplants.2022043658
Braden J Passias, John J Verre, Kyle McGrath, Daniel T DeGenova, Benjamin C Taylor

Nitinol is a shape-memory alloy that has many diverse applications in the field of orthopedics. There have been no previous investigations reporting clinical or radiographic outcomes of the use of nitinol staples in the definitive stabilization of the pubic symphysis. A retrospective chart review was completed on 42 patients who underwent operative stabilization of pubic symphyseal disruption at an urban level-1 trauma center. Patients treated with pelvic staples alone, or in conjunction with traditional plates and screws, were compared with those treated without the use of a shape memory alloys. Thirty-four patients were included for final analysis (8 staples and 26 controls) in this investigation. Three of eight patients in the pelvic staple group had implant failures, with two having a loss of reduction (25%); this was not significantly different from the seven hardware failures (P = 0.61) seen in the control group without any loss of reduction (P = 0.17). Failures in the nitinol staple group occurred earlier at 17.3 days compared with the control group at 101.7 days (P = 0.003). There were no significant differences between groups with regards to any of the other pre- or postoperative variables investigated. The use of nitinol staples vs. traditional plate and screw constructs for stabilizing the pubic symphysis did not result in more clinical failures. The hardware failures identified in the nitinol staple group occurred significantly earlier in the postoperative period, and were associated with a loss of reduction of the pubic symphysis.

镍钛诺是一种形状记忆合金,在骨科领域有许多不同的应用。以前没有研究报告使用镍钛诺钉固定耻骨联合的临床或影像学结果。回顾性分析了42例在城市一级创伤中心接受耻骨联合骨折手术稳定治疗的患者。单独使用骨盆钉或结合传统钢板和螺钉治疗的患者与不使用形状记忆合金治疗的患者进行比较。在本次调查中,34例患者(8例订书钉和26例对照组)被纳入最终分析。骨盆钉组8例患者中有3例植入物失败,其中2例复位丢失(25%);这与对照组的7例硬件故障(P = 0.61)没有显著差异,没有任何复位损失(P = 0.17)。与对照组的101.7天相比,镍钛诺钉钉组的失败发生在17.3天较早(P = 0.003)。在其他术前或术后变量的调查中,两组之间没有显著差异。使用镍钛诺固定钉与传统的钢板螺钉固定耻骨联合并没有导致更多的临床失败。在镍钛诺钉钉组中发现的硬体故障在术后发生的时间明显更早,并且与耻骨联合复位的丧失有关。
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引用次数: 1
Is CT-A Always Reliable in Detecting Active Bleeding in Closed Pelvic Fractures? Management of a Case with Multiple Closed Pelvic Fratures and Internal Iliac Artery Bleeding. CT-A检测闭合性骨盆骨折活动性出血是否可靠?多发性闭合性骨盆骨折合并髂内动脉出血1例的治疗。
Q3 Dentistry Pub Date : 2022-01-01 DOI: 10.1615/JLongTermEffMedImplants.2022042027
Anastasia Vasilopoulou, Vasileios Mamalis, Spyridon J Maris, Emmanouel Antonogiannakis, Iakovos Roupinas, Stavros Angelis, Stamatios Kyriakopoulos, Antonios Tsanis, Alexandros P Apostolopoulos

One of the most important complications of pelvic injuries is hemorrhage which can be attributed to the venus plexus of the pelvis, the damaged bone on the fracture site, or in 15% of cases to arterial cause. In the last case mortality could reach 70%. Clinical case presentation, a 77-year-old man, presented in the emergency department of our hospital hemodynamically unstable due to fall from height (3 meters) with comminuted bilateral fractures of the pubic rami, right sacral and iliac wing fracture, right acetabular fracture, fractures of transverse processes of the first, second, and fifth lumbar spine vertebrae and a periprothetic fracture of the right femur. Advanced trauma life support (ATLS) protocol was followed throughout. Computed tomography (CT) scans and CT angiography performed, showed the above mentioned pelvic fractures that did not require stabilization, without further injuries, and a well described retroperitoneal hematoma without any evidence of active bleeding. During the resuscitation process the patient developed cardiac arrest and cardiopulmonary resuscitation (CPR) protocol was followed. The patient was intubated and retained his cardiac rhythm. However, he remained unstable and an angiography was then performed that revealed internal iliac artery bleeding and embolism of the internal iliac artery was performed. The patient was stabilized and was transferred to the intensive care unit for further management. Arterial hemorrhage due to pelvic injury is less common, however presents with high rates of mortality. CT angiography may in some cases not reveal existing active bleeding, misleading the clinician. Therefore, in patients with high clinical suspicion of arterial pelvic hemorrhage who remain unstable during the initial resuscitation and do not present with other primary source of bleeding, an angiography and embolism should be performed as soon as possible.

骨盆损伤最重要的并发症之一是出血,这可归因于骨盆金星丛,骨折部位的骨受损,或在15%的病例中动脉原因。最后一例死亡率可达70%。临床病例介绍,77岁男性,因高空坠落(3米)导致双侧耻骨粉碎性骨折,右侧骶髂翼骨折,右侧髋臼骨折,第一、第二、第五腰椎横突骨折,右侧股骨假体周围骨折,血流动力学不稳定,在我院急诊科就诊。全程遵循高级创伤生命支持(ATLS)方案。计算机断层扫描(CT)和CT血管造影显示,上述骨盆骨折不需要稳定,没有进一步的损伤,以及描述良好的腹膜后血肿,没有任何活动性出血的证据。在复苏过程中,患者出现心脏骤停,并遵循心肺复苏(CPR)方案。病人插管后保持了心律。然而,他仍然不稳定,随后进行了血管造影,发现髂内动脉出血,并进行了髂内动脉栓塞。患者病情稳定后转至重症监护病房接受进一步治疗。骨盆损伤引起的动脉出血不太常见,但死亡率很高。CT血管造影可能在某些情况下没有显示现有的活动性出血,误导临床医生。因此,对于临床高度怀疑盆腔动脉出血的患者,在初次复苏时仍不稳定且无其他主要出血来源,应尽快行血管造影和栓塞术。
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引用次数: 0
Evaluation of Marginal and Internal Fit at Implant-Abutment Interface of Original and Compatible Nonoriginal Abutments. 原基牙与兼容非原基牙种植体-基牙界面边缘与内部配合评价。
Q3 Dentistry Pub Date : 2022-01-01 DOI: 10.1615/JLongTermEffMedImplants.2022040297
Antoine Berberi, Georges Tehini, Bouchra Hjeij, Georges Aoun

Is to measure the peripheral and internal gap at the implant-abutment interface of an implant system connected to its original or compatible non-original abutments. Twenty implants were assembled with four different types of abutments having the same conical internal interface. All abutments were considered compatible with Tx Astra Tech Implant SystemTM. Four groups were created and each group of five implants was connected to a different abutment; Ti DesignTM abutments (group A), DualTM abutments (group B), Natea plusTM abutments (group C) and ImplanetTM abutments (group D). The peripheral gaps between implant and abutment were observed in three points facing the flat surface of the abutment. The implant-abutment assemblies were then embedded in resin and grinded in the mesio-distal direction of the scalloped abutment margin using a diamond disk at very low speed and under water-cooling. The inner aspect of the implant abutment interface was observed in three different points, on the coronal border of the connection, in the middle area and on the apical border of the implant-abutment interface. The mean gap width was 0.543 ± 0.09 μm for group A and, respectively, 0.708 ± 0.1232 μm, 0.726 ± 0.0891 μm and 0.818 ± 0.0851 μm for groups B, C and D. When comparing group, A to B and C, a highly significant difference in numbers was obvious while an even higher variation was observed with group D. External and internal fit of components is better when using original components.

是测量种植体系统与原有或兼容的非原有基台连接的种植体-基台界面处的周边和内部间隙。将20个种植体与四种不同类型的基台组装在一起,这些基台具有相同的锥形内部界面。所有基台均被认为与Tx Astra Tech Implant SystemTM兼容。制作四组,每组五个种植体连接到不同的基台;采用Ti DesignTM基牙(A组)、DualTM基牙(B组)、Natea plusTM基牙(C组)和ImplanetTM基牙(D组)。种植体与基牙之间的间隙分布在三个面向基牙平面的点上。然后将种植体-基台组件包埋在树脂中,并使用金刚石盘在极低速和水冷却下沿扇形基台边缘的中-远端方向进行研磨。在种植体-基牙界面的冠状边界、中间区域和根尖边界三个不同的点上观察种植体-基牙界面的内部。A组的平均间隙宽度为0.543±0.09 μm, B、C、d组的平均间隙宽度为0.708±0.1232 μm, 0.726±0.0891 μm, 0.818±0.0851 μm。A组与B、C组的差异极显著,d组的差异更大。
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引用次数: 0
Avoiding Complications of Locking Plating for Proximal Humerus Fractures. 锁定钢板治疗肱骨近端骨折避免并发症。
Q3 Dentistry Pub Date : 2022-01-01 DOI: 10.1615/JLongTermEffMedImplants.2022040229
Zinon T Kokkalis, Efstratios Papanikos, Ekaterini Bavelou, Andreas Panagopoulos, Panagiotis Megas

Proximal humeral fractures are very common, especially among elderly people with osteoporosis. The treatment methods are numerous, according to the characteristics of the patient and the fracture, as well as the surgeon's preference. These fractures can be treated either conservatively or operatively with closed or open reduction and internal fixation, or arthroplasty. During the past decades, with the advances in osteosynthesis and the establishment of locking plates, many surgeons prefer managing humeral fractures with open reduction and internal fixation with locking plates. Even though this is a widespread method of treatment, many studies report high complication rates, including perioperative and hardware complications. This article presents the most common complications a surgeon may face when managing this kind of fractures, as well as intraoperative techniques that can be used to avoid them.

肱骨近端骨折非常常见,尤其是在老年骨质疏松患者中。根据患者和骨折的特点以及外科医生的喜好,治疗方法多种多样。这些骨折可以保守治疗或手术治疗,采用闭合或开放复位内固定或关节置换术。在过去的几十年里,随着骨融合术的进步和锁定钢板的建立,许多外科医生倾向于用切开复位和锁定钢板内固定来治疗肱骨骨折。尽管这是一种广泛的治疗方法,但许多研究报告了高并发症发生率,包括围手术期和硬件并发症。本文介绍了外科医生在处理此类骨折时可能面临的最常见并发症,以及可用于避免这些并发症的术中技术。
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引用次数: 0
Higher Infection Rate after ACL Reconstruction with Hamstrings Tendon Autografts Compared with Bone Patellar Bone Tendon Autografts: A Review. 自体腘绳肌腱重建前交叉韧带的感染率高于自体髌骨肌腱重建前交叉韧带。
Q3 Dentistry Pub Date : 2022-01-01 DOI: 10.1615/JLongTermEffMedImplants.2022041978
Jim D Georgoulis, Andreas F Mavrogenis, Ioannis Gkiatas, Christos N Chatzipapas, Dimitrios Koulalis, Dimitrios Mastrokalos, Michael Elias Hantes, Anastasios D Georgoulis

Infection after anterior cruciate ligament reconstruction is a rare but devastating complication resulting in a deleterious impact on knee function as well as an increased related cost for treatment and rehabilitation for the patients. There are conflicting reports regarding the rate of infection between bone patellar tendon bone (BPTB) and hamstrings tendon (HT) autografts for anterior cruciate ligament reconstruction. Therefore, we performed this review to summarize all the available data regarding the risk of infection after ACL reconstruction, to provide insight on the infection risk between BPTB and HT autografts, and to discuss current recommendations for the diagnosis and treatment of these infections. The incidence and risk of infection after ACL reconstruction with HT graft is higher compared with BPTB grafts. The most commonly subacute and late infections, quadruple type, need for cannulated instruments for harvesting, size and shape and fixation of the extra-tunnel material of the HT are important risk factors for infection. Combined antibiotics administration and adequate arthroscopic lavage and debridement are the optimal treatments for ACL reconstruction infection. Early diagnosis and treatment is the most important predictor for graft retention, which accounts more commonly for BPTB grafts. The treating physicians should be aware of the higher incidence of infection after ACL reconstruction with HT graft, as well as for the need for a high clinical suspicion for early diagnosis of the infection. These will increase the possibility of eradication of the infection and retention of the graft.

前交叉韧带重建后的感染是一种罕见但破坏性的并发症,它会对膝关节功能产生有害影响,并增加患者治疗和康复的相关费用。关于髌腱骨(BPTB)和腘绳肌腱(HT)自体移植物用于前交叉韧带重建的感染率,有相互矛盾的报道。因此,我们进行了这篇综述,总结了所有关于ACL重建后感染风险的可用数据,以提供BPTB和HT自体移植物之间感染风险的见解,并讨论当前诊断和治疗这些感染的建议。与BPTB移植相比,HT移植重建ACL后感染的发生率和风险更高。最常见的亚急性和晚期感染,四重型,需要插管工具进行采集,HT的大小和形状以及隧道外材料的固定是感染的重要危险因素。联合抗生素治疗和充分的关节镜灌洗和清创是前交叉韧带重建感染的最佳治疗方法。早期诊断和治疗是移植物滞留最重要的预测因素,这在BPTB移植物中更为常见。治疗医师应意识到HT移植重建前交叉韧带后感染的发生率较高,并且需要高度的临床怀疑以早期诊断感染。这将增加根除感染和保留移植物的可能性。
{"title":"Higher Infection Rate after ACL Reconstruction with Hamstrings Tendon Autografts Compared with Bone Patellar Bone Tendon Autografts: A Review.","authors":"Jim D Georgoulis,&nbsp;Andreas F Mavrogenis,&nbsp;Ioannis Gkiatas,&nbsp;Christos N Chatzipapas,&nbsp;Dimitrios Koulalis,&nbsp;Dimitrios Mastrokalos,&nbsp;Michael Elias Hantes,&nbsp;Anastasios D Georgoulis","doi":"10.1615/JLongTermEffMedImplants.2022041978","DOIUrl":"https://doi.org/10.1615/JLongTermEffMedImplants.2022041978","url":null,"abstract":"<p><p>Infection after anterior cruciate ligament reconstruction is a rare but devastating complication resulting in a deleterious impact on knee function as well as an increased related cost for treatment and rehabilitation for the patients. There are conflicting reports regarding the rate of infection between bone patellar tendon bone (BPTB) and hamstrings tendon (HT) autografts for anterior cruciate ligament reconstruction. Therefore, we performed this review to summarize all the available data regarding the risk of infection after ACL reconstruction, to provide insight on the infection risk between BPTB and HT autografts, and to discuss current recommendations for the diagnosis and treatment of these infections. The incidence and risk of infection after ACL reconstruction with HT graft is higher compared with BPTB grafts. The most commonly subacute and late infections, quadruple type, need for cannulated instruments for harvesting, size and shape and fixation of the extra-tunnel material of the HT are important risk factors for infection. Combined antibiotics administration and adequate arthroscopic lavage and debridement are the optimal treatments for ACL reconstruction infection. Early diagnosis and treatment is the most important predictor for graft retention, which accounts more commonly for BPTB grafts. The treating physicians should be aware of the higher incidence of infection after ACL reconstruction with HT graft, as well as for the need for a high clinical suspicion for early diagnosis of the infection. These will increase the possibility of eradication of the infection and retention of the graft.</p>","PeriodicalId":16125,"journal":{"name":"Journal of long-term effects of medical implants","volume":"32 3","pages":"9-13"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40417041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
A Lumbar Paravertebral Space Ultrasound Lumbar Plexus Block Technique for Hip Fracture Surgery in the Elderly. 腰椎椎旁间隙超声腰丛阻滞技术在老年髋部骨折手术中的应用。
Q3 Dentistry Pub Date : 2022-01-01 DOI: 10.1615/JLongTermEffMedImplants.2022042501
Theodosios Saranteas, Rizos Souvatzoglou, Andreas Kostroglou, Spyridon Sioutis, Kalliopi Christodoulaki, Dimitrios Koulalis, Eleftheria Soulioti, Thomas Papadimos, Andreas F Mavrogenis

Ultrasound imaging of peripheral nerves is challenging in elderly population. In cases involving the lumbar plexus (LP), we have employed ultrasound imaging and neurostimulation guidance for successful localization and block of the LP. The postero-medial segment of the psoas muscle (PSM), superior to the vertebral body and anterior to the transverse process ("corner pocket") was used as an imaging landmark for the implementation of the LP block. By advancing the needle through the lateral abdominal wall into the "corner pocket" we were afforded a seamless advancement of the needle into the postero-medial segment of the PSM, which is the standard anatomic position of LP in the PSM. Forty-eight patients in whom ultrasound imaging of the LP was not feasible, but the "corner pocket" was clearly depicted were included in the study. LP block characteristics and adverse events were recorded. The LP was localized in 43/48 patients. The average imaging, needling, and performance times to complete the block were 51 sec (range, 6-180 sec), 81 sec (range, 16-236 sec), and 132 sec (range, 24-270 sec), respectively. The median number of needle redirections per patient was 5.5 (range, 1-13). The local anesthetic spread was visualized in the postero-medial segment of the PSM in 39/43 patients. No complications were recorded. The imaging, needling, and performance times, as well as the number of needle passes did not significantly differ between obese and non-obese patients. In conclusion, in cases with challenging ultrasound imaging of the LP, ultrasound-assisted LP block can be accomplished through the lateral abdominal wall by using as an imaging landmark the "corner pocket" at the postero-medial quadrant of the PSM.

老年人群的周围神经超声成像具有挑战性。在涉及腰丛(LP)的病例中,我们采用超声成像和神经刺激指导成功定位和阻断腰丛。腰大肌后内侧段(PSM)位于椎体上方,横突前方(“角袋”)被用作实施LP阻滞的成像标志。通过将针穿过腹壁推进到“角袋”,我们可以将针无缝推进到PSM的后内侧段,这是LP在PSM中的标准解剖位置。48例LP超声成像不可行,但“角袋”清晰描绘的患者纳入研究。记录LP阻滞特征和不良事件。43/48例患者LP定位。成像、针刺和完成阻滞的平均时间分别为51秒(范围6-180秒)、81秒(范围16-236秒)和132秒(范围24-270秒)。每位患者重定向针头的中位数为5.5次(范围1-13次)。43例患者中有39例在PSM后内侧段可见局麻扩散。无并发症记录。肥胖和非肥胖患者的成像、针刺和表现时间以及针刺次数没有显著差异。综上所述,在LP超声成像困难的情况下,超声辅助下的LP阻断可以通过腹侧壁完成,将PSM后内象限的“角袋”作为成像标志。
{"title":"A Lumbar Paravertebral Space Ultrasound Lumbar Plexus Block Technique for Hip Fracture Surgery in the Elderly.","authors":"Theodosios Saranteas,&nbsp;Rizos Souvatzoglou,&nbsp;Andreas Kostroglou,&nbsp;Spyridon Sioutis,&nbsp;Kalliopi Christodoulaki,&nbsp;Dimitrios Koulalis,&nbsp;Eleftheria Soulioti,&nbsp;Thomas Papadimos,&nbsp;Andreas F Mavrogenis","doi":"10.1615/JLongTermEffMedImplants.2022042501","DOIUrl":"https://doi.org/10.1615/JLongTermEffMedImplants.2022042501","url":null,"abstract":"<p><p>Ultrasound imaging of peripheral nerves is challenging in elderly population. In cases involving the lumbar plexus (LP), we have employed ultrasound imaging and neurostimulation guidance for successful localization and block of the LP. The postero-medial segment of the psoas muscle (PSM), superior to the vertebral body and anterior to the transverse process (\"corner pocket\") was used as an imaging landmark for the implementation of the LP block. By advancing the needle through the lateral abdominal wall into the \"corner pocket\" we were afforded a seamless advancement of the needle into the postero-medial segment of the PSM, which is the standard anatomic position of LP in the PSM. Forty-eight patients in whom ultrasound imaging of the LP was not feasible, but the \"corner pocket\" was clearly depicted were included in the study. LP block characteristics and adverse events were recorded. The LP was localized in 43/48 patients. The average imaging, needling, and performance times to complete the block were 51 sec (range, 6-180 sec), 81 sec (range, 16-236 sec), and 132 sec (range, 24-270 sec), respectively. The median number of needle redirections per patient was 5.5 (range, 1-13). The local anesthetic spread was visualized in the postero-medial segment of the PSM in 39/43 patients. No complications were recorded. The imaging, needling, and performance times, as well as the number of needle passes did not significantly differ between obese and non-obese patients. In conclusion, in cases with challenging ultrasound imaging of the LP, ultrasound-assisted LP block can be accomplished through the lateral abdominal wall by using as an imaging landmark the \"corner pocket\" at the postero-medial quadrant of the PSM.</p>","PeriodicalId":16125,"journal":{"name":"Journal of long-term effects of medical implants","volume":"32 3","pages":"65-71"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40716831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Effect of Enamel Matrix Derivative and N-Acetyl Cysteine on Proliferation and Osteogenic Activity of Dental Pulp Stem Cells. 牙釉质基质衍生物和n -乙酰半胱氨酸对牙髓干细胞增殖和成骨活性的影响。
Q3 Dentistry Pub Date : 2022-01-01 DOI: 10.1615/jlongtermeffmedimplants.2022040074
R. Amid, Mina Iranparvar Alamdari, M. Kadkhodazadeh
Successful bone regeneration often requires induction by signaling molecules. Enamel matrix derivative (EMD) is said to enhance initial phases of healing. N-acetyl cysteine (NAC) is a molecule assumed to enhance osteogenesis and induce osteoblastic differentiation. This study sought to compare effects of EMD and NAC on proliferation, mineralization, and enzymatic activity of dental pulp mesenchymal stem cells (DPSCs). DPSCs were cultured on mineralized bone allograft (MBA) powder. After 24 hours, EMD in concentrations of 10, 50, and 100 μg/mL and NAC in 5 mM concentration were added. Methyl thiazolyl tetrazolium (MTT) assay was used for cell proliferation assessment at 1, 2, and 3 days. Osteoblastic differentiation of DPSCs was evaluated at 30 days, by alizarin red staining and assessment of alkaline phosphatase (ALP) activity. Both EMD and NAC caused time-dependent reduction of cell proliferation compared with the negative control. Maximum proliferation of DPSCs was observed in the 10 μg/mL EMD group at all time points, whereas NAC caused higher ALP activity and mineralization of DPSCs compared with EMD. In vitro application of NAC, as a signaling molecule, may effectively enhance bone regeneration by the induction of mineralization and enzymatic activity, despite the resultant reduction in cell proliferation rate.
成功的骨再生通常需要信号分子的诱导。牙釉质基质衍生物(EMD)被认为可以增强初始阶段的愈合。n -乙酰半胱氨酸(NAC)被认为是一种促进成骨和诱导成骨细胞分化的分子。本研究旨在比较EMD和NAC对牙髓间充质干细胞(DPSCs)增殖、矿化和酶活性的影响。在矿化同种异体骨(MBA)粉上培养DPSCs。24 h后,分别加入浓度为10、50、100 μg/mL的EMD和浓度为5 mM的NAC。在第1、2、3天采用甲基噻唑四氮唑(MTT)法评估细胞增殖情况。通过茜素红染色和碱性磷酸酶(ALP)活性评估DPSCs在30天后的成骨分化。与阴性对照相比,EMD和NAC均引起细胞增殖的时间依赖性减少。10 μg/mL EMD组DPSCs在各时间点增殖最大,NAC使DPSCs的ALP活性和矿化率高于EMD。体外应用NAC作为一种信号分子,可以通过诱导矿化和酶活性有效地促进骨再生,尽管由此导致细胞增殖率降低。
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引用次数: 0
Assessment of Inferior Alveolar Nerve Position at the Region of First and Second Mandibular Molars in Dentate and Edentulous Sites Using Cone Beam Computed Tomography: A Cross-Sectional Study. 锥形束计算机断层扫描评估下颌第一和第二磨牙有齿和无齿区域下牙槽神经位置:一项横断面研究。
Q3 Dentistry Pub Date : 2022-01-01 DOI: 10.1615/JLongTermEffMedImplants.2022039842
Zahra Safari, Mitra Ghazizadeh Ahsaie, Yaser Safi

Determining the position of the Inferior alveolar nerve (IAN) is an important factor prior to any surgical procedure in the mandible such as dental implant insertion and surgical tooth extraction. The aim of this study was to compare the position of IAN in partially edentulous patients in the lower first and second molars in both missing and dentate sides. A total of 200 CBCT scans were chosen randomly and examined. On cross-sectional views, the distance between lower border of IAN canal and upper border of inferior cortex of mandible (IC) were measured at the site of dentate and edentulous mandibular first and second molar. Paired-sample t-test was used to analyze and compare measurements on right and left sides. A total of 100 males and 100 females with mean age of 46.05 ± 12.33 years were included. The IC distance measured in four pairs were as follows: Pair one: 80 cases with right missing 6 (mean ± SD = 3.73 ± 1.29 mm) and left present 6 (mean ± SD = 3.42 ± 1.20 mm), Pair two: 20 cases with right present 6 (mean = 3.20 ± 1.48 mm) and left missing 6 (mean ± SD = 3.96 ± 1.62 mm), Pair three: 54 cases of right missing 7 (mean ± SD = 3.83 ± 1.74 mm) and left present 7 (mean ± SD = 3.62 ± 1.74 mm), and Pair four: 46 case of right present 7 (mean ± SD = 3.49 ± 1.56 mm) and left missing 7 (mean ± SD = 3.84 ± 1.42). The IAN was statistically more distant from inferior cortex of mandible in the edentulous parts compared with the non-edentulous part (P < 0.05). The IAN was positioned farther from the inferior cortex of mandible in edentulous sites compared with dentate parts. Cautious consideration is essential in any surgical procedure and dental implant operations to prevent IAN injury.

确定下牙槽神经(IAN)的位置是任何下颌骨外科手术(如植牙插入和拔牙)前的重要因素。本研究的目的是比较部分无牙患者在缺失侧和有齿侧的下第一和第二磨牙的IAN位置。随机选择200张CBCT扫描图进行检查。在横切面上,测量下颌第一、第二磨牙有齿和无齿位置的下颌下皮质(IC)上缘与IAN管下缘之间的距离。采用配对样本t检验对左右两侧的测量值进行分析和比较。共纳入男性100例,女性100例,平均年龄46.05±12.33岁。IC的距离以四对如下:对一个:80例对失踪6(平均数±标准差= 3.73±1.29毫米)和左6(平均数±标准差= 3.42±1.20毫米),一对二:20例对目前6(意味着= 3.20±1.48毫米)和失踪6(平均数±标准差= 3.96±1.62毫米),对三:54例对失踪的7(平均数±标准差= 3.83±1.74毫米)和左7(平均数±标准差= 3.62±1.74毫米),和一对四:右侧缺失7例(平均±SD = 3.49±1.56 mm),左侧缺失7例(平均±SD = 3.84±1.42)。无牙部分的IAN距离下颌骨下皮层较无牙部分远(P < 0.05)。与齿形部分相比,下颌无牙区IAN的定位距离下皮层较远。谨慎的考虑是必要的,在任何外科手术和牙科种植手术,以防止伊恩损伤。
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引用次数: 0
Epithelioid Hemangioma of Bone: A Rare Vascular Neoplasm. A Case Report and Literature Review. 骨上皮样血管瘤:一种罕见的血管肿瘤。1例报告及文献回顾。
Q3 Dentistry Pub Date : 2022-01-01 DOI: 10.1615/JLongTermEffMedImplants.2022041868
Olga Savvidou, Penelope Korkolopoulou, Eleftheria Lakiotaki, Spyros Sioutis, Christos Vottis, Panagiotis Gavriil, Dimitra Melissaridou, Panayiotis Papagelopoulos

Epithelioid hemangioma (EH) of bone is a rare benign, albeit locally aggressive vascular neoplasm. It is usually solitary and involves the metaphysis or diaphysis of long tubular bones, especially in the lower extremities. Rarely it may present as multifocal lesions. The differential diagnosis includes malignant vascular bone tumors such as epithelioid hemangioendothelioma and epithelioid angiosarcoma. Clinical presentation and radiographic and histological findings are not specific and diagnosis is based mostly on immunohistochemical and molecular studies. There is no consensus regarding the optimal treatment. Curettage and bone grafting or en bloc resection are the current treatment options, however local recurrence have been reported. We present a case of multifocal EH of the distal tibia, distal fibula and hindfoot in a 38 year-old male managed with curettage, radiofrequency ablation and cement osteoplasty. The imaging features, histological findings and treatment options of this rare vascular tumor are discussed.

骨上皮样血管瘤(EH)是一种罕见的良性血管肿瘤,尽管局部具有侵袭性。它通常是孤立的,累及长管状骨的干骺端或干骺端,特别是在下肢。很少表现为多灶性病变。鉴别诊断包括恶性血管骨肿瘤,如上皮样血管内皮瘤和上皮样血管肉瘤。临床表现、放射学和组织学表现不特异性,诊断主要基于免疫组织化学和分子研究。关于最佳治疗方法尚无共识。刮除、植骨或整体切除是目前的治疗选择,但也有局部复发的报道。我们报告一例胫骨远端、腓骨远端和后足的多灶性EH,患者为38岁男性,采用刮除、射频消融和骨水泥成形术治疗。本文讨论了这种罕见血管性肿瘤的影像学特征、组织学表现和治疗方案。
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引用次数: 0
Surgical Removal of Bone Bridge and Interposition of the Extensor Digitorum Brevis in the Treatment of Calcaneonavicular Coalition in Pediatric Patients: A Case Series, Short Review, and Commentary. 手术切除骨桥和插入指短伸肌治疗小儿跟舟关节联合:一个病例系列,简短回顾和评论。
Q3 Dentistry Pub Date : 2022-01-01 DOI: 10.1615/JLongTermEffMedImplants.2022042255
Stavros Angelis, Dimitrios Myrgiotis, Alexandros P Apostolopoulos, Eleftherios Mandragos, Nikolaos-Christos Statyris, Dimitrios K Filippou, John Ν Michelarakis

This study retrospectively presents a single-clinic case series of pediatric patients with calcaneonavicular coalition treated by surgical removal of the bone bridge and interposition of the extensor digitorum brevis. This technique is currently the most cited and utilized protocol in operative treatment. Clinical, functional, and radiological results are analyzed and compared with related research. This is a single-clinic retrospective study, conducted for a period of 15 years. One independent investigator reviewed medical records and conducted a de-identified preoperative, inpatient, and postoperative assessment focused on demographic data, history and clinical evaluation, imaging assessment, American Orthopedic Foot and Ankle Society (AOFAS) scoring, and complication analysis. Of 34 patients, 13 met the inclusion criteria. Mean patient age was 11.2 years; 10 were males and 3 were females. Pathology concerned the right lower limb in eight cases and the left in five. Mean time between diagnosis and surgical intervention was 4.3 months and mean postoperative follow-up was 27.2 months. Thorough overview of reported symptoms, identified signs, imaging evaluation, functional outcomes, and adverse effects was performed. Bone bridge removal and interposition of the extensor digitorum brevis is an effective method of treating the condition. Despite drawbacks, results are comparable or even, to some degree, superior to other techniques.

本研究回顾性报道了一组通过手术切除骨桥和插入指短伸肌治疗跟舟关节联合的单诊所儿童病例。该技术是目前应用最多的手术治疗方案。将临床、功能和放射学结果与相关研究进行分析和比较。这是一项为期15年的单诊所回顾性研究。一名独立调查人员审查了医疗记录,并对术前、住院和术后进行了去识别评估,重点是人口统计数据、病史和临床评估、影像学评估、美国骨科足踝协会(AOFAS)评分和并发症分析。34例患者中,13例符合纳入标准。患者平均年龄11.2岁;其中男性10人,女性3人。病理涉及右下肢8例,左下肢5例。从诊断到手术干预的平均时间为4.3个月,术后平均随访时间为27.2个月。对报告的症状、已识别的体征、影像学评估、功能结果和不良反应进行了全面的概述。骨桥切除和插入指短伸肌是治疗此病的有效方法。尽管有缺点,但结果与其他技术相当,甚至在某种程度上优于其他技术。
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Journal of long-term effects of medical implants
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