Journal of long-term effects of medical implants最新文献

Considering the widespread use of dental implants, a precise definition for peri-implant tissue health and an appropriate classification for peri-implant diseases are imperative for researchers and dental clinicians. However, absence of a unanimous definition and an efficient classification system has created controversies in the published reports regarding the epidemiology and prevalence of peri-implant diseases. Moreover, lack of a standard system for differentiation of different grades of peri-implantitis further complicates the interpretation of reports regarding the diagnosis prevalence, treatment, and outcome of such conditions, and highlights the need for a classification system based on the severity of disease. Almost all of the currently available classification systems focus on the assessment of health or disease status of the tissues around loaded implants. The purpose of the present study is to propose a classification/scoring system for peri-implant tissue health before and after prosthetic loading. This grading system can aid the researchers and dental clinicians in assessment of peri-implant tissue condition both before and after prosthetic loading of dental implants.

Cancer is established as a major contributor to global burden as millions of deaths are reported every year. Advances in molecular, epidemiologic and clinical research have led to significant improvements in prevention, screening and treatment of tumors. The purpose of the study is to describe the progress of oncology clinical trials performed in Greece during the past decade and the obstacles that still need to be addressed in cancer research. A search was conducted in the public database EU Clinical Trials Register using the algorithm 'cancer AND Greece'. Results included relevant trials approved between 2010 and 2020. A total of 480 trials were approved for conduct in Greece from 2010 to 2020. The majority are multinational, phase III trials, exploring the efficacy and safety of agents in the management of lung cancer and multiple myeloma. A variety of small-molecules and monoclonal antibodies has and is being tested against key binding targets. Based on their promising effects on patients' responses and outcomes, many have been marketed for the treatment of several cancer types and are considered milestones in cancer discovery. It goes without saying that oncology research has made tremendous steps towards the development of potent and tolerable anticancer agents, with Greece having an active role. Current efforts focus on the use of alternative designs and tools aiming at further improving patients' survival and quality of life, while globalization of clinical research is also a matter of high importance.

Lisfranc injuries result when the bones or ligaments that support the midfoot are torn, and the classifications of these injuries are based on the coronal displacement of the metatarsals. On the saggital plane, the first metatarsal is usually dorsally dislocated due to dorsal ligament weakness. We present a case report of a 29-year-old woman who sustained a Lisfranc injury of her right foot with plantar subluxation of the first metatarsal, which was treated with open reduction and internal fixation of the first metatarsal and fusion of the second metatarsal.

The aim of the present study is to compare the periodontal health and marginal bone loss (MBL) between single-crown dental implants placed interdentally and mesial to the edentulous space. Patients treated with single-crown dental implants between 01/04/2014 and 01/04/2021 were included in the study. The included patients were divided into 2 groups. Group 1 consisted of single implant crowns inserted interdentally with a distal neighboring mandibular second molar and Group 2 consisted of single molar implant crowns inserted distally to the second premolar tooth without a neighboring second molar. The measurements for probing pocket depth, gingival index, and plaque index were made in both groups at the 60-month control session to evaluate periodontal health of the single-crown dental implants. The marginal bone levels of distal and mesial aspects of all implants were measured at the 60-month control session on panoramic radiographs. Forty-six and sixty-one patients were included in Groups 1 and 2, respectively. There was a significantly higher distal MBL in Group 2 compared with Group 1 (P < 0.05). Mesial MBL was higher in Group 1, however, this difference was not significant. The periodontal parameters of probing pocket depth, gingival index, and PI were all significantly higher in Group 1 compared with Group 2 at the 60-month control evaluation (P < 0.05). Single-crown dental implants placed interdentally may show decreased distal MBL and periodontal health compared with single-crown dental implants placed mesial to the edentulous space.