Journal of long-term effects of medical implants最新文献

A novel approach to augmenting the osteogenic properties of nano-hydroxyapatite (nHA) is doping it with bioactive ions such as strontium (Sr) and zinc (Zn). The incorporation of Sr and Zn into the nano-hydroxyapatite structure enhances its bioactivity, providing a more favorable environment for osteogenesis. The aim of this review is to evaluate the osteogenic potential of Sr/Zn-doped nano-hydroxyapatite coatings on dental implants, focusing on their effects on osseointegration and bone regeneration. A comprehensive literature search was conducted to identify relevant studies. The following databases were systematically searched: PubMed, Scopus, Web of Science, Embase, and the Cochrane Library through September 2024. The search was designed to capture a wide range of studies from biomedical, clinical, and materials science. This systematic review initially identified 16 studies, with 6 excluded after screening for relevance. Of the 10 remaining, one was further excluded for not meeting criteria. Nine studies were included in the final analysis, out of which 4 were animal studies and 5 were in vitro studies but heterogeneity prevented a meta-analysis. Data extraction focused on study details, mechanisms, in vitro and in vivo results, and conclusions. Results indicated that Sr/ Zn-doped nHA plasma-sprayed coatings on titanium dental implants significantly enhance osteogenic potential. The collective evidence from the relevant studies shows that the benefits of Sr/Zn-doped HA materials for biomedical applications are multifaceted. They have demonstrated significant improvements in bioactivity, osseointegration, osteogenesis, antibacterial properties, and mechanical performance, making them promising candidates for a range of orthopedic, dental, and cranial implants.

Implant dentistry is a rapidly evolving field where cost efficiency and sustainability are becoming increasingly important considerations. The rising cost of implant components, such as impression copings, healing abutments, and cover screws, has led clinicians to consider their reuse as a means to reduce expenses and minimize material waste in dental practice. These components, traditionally designated for single use, are crucial in ensuring implant accuracy and patient safety. Various systematic reviews evaluate the reuse of dental impression copings, healing abutments, and cover screws in implant dentistry, a practice gaining attention due to the rising costs of implant components. Publications from the last ten years in the PubMed database were analyzed, with a focus on resterilization efficacy, accuracy of reuse, and reported biological or mechanical consequences. Out of 30 articles reviewed, 17 met the criteria for final analysis. Findings suggest mixed evidence on clinical success rates and safety, with notable considerations for cost-effectiveness and sustainability. This review provides an evidence-based assessment of the viability and potential implications of reusing these components in clinical practice. This review also addresses this gap by evaluating the literature on the reuse of these components, focusing on biological safety, mechanical integrity, accuracy, cost-effectiveness, and sustainability.

This study aimed to assess the relationship of impacted mandibular third molars with the mandibular canal on cone beam computed tomography (CBCT) scans. This cross-sectional study was conducted on CBCT scans of 137 patients with 204 impacted mandibular third molars. The relation of age, gender, class of impaction, anatomical position of canal relative to tooth (buccal, lingual, inferior, inter-radicular), tooth angulation (mesioangular, vertical, distoangular, horizontal), relationship of tooth with the mandibular canal (no contact, in contact, relation), relationship of tooth with the mandibular cortex, anatomical site of contact of tooth with the mandibular cortex (buccal, lingual, inferior), and the impression of canal (grooving, no effect) on impacted teeth were evaluated. Data were analyzed using one-way ANOVA, Chi-square test and Fisher's exact test. Class B of impaction (78.9%), inferior position of canal relative to the impacted tooth (53.9%) and mesioangular angulation (53.4%) had the highest frequency, respectively. The relationship of tooth with the mandibular canal was "relation" in most cases (53.4%) followed by no contact (26.9%) and in contact (19.6%). Significant associations were noted between depth of impaction (P < 0.001), tooth angulation (P = 0.024), anatomical position of canal relative to tooth (P < 0.001), relationship of tooth with the mandibular cortex (P = 0.032) and anatomical site of contact of tooth with the mandibular cortex (P = 0.013) with the impacted tooth-mandibular canal relationship. CBCT provides accurate information about the relationship of impacted third molars with the mandibular canal and can decrease the risk of traumatization of inferior alveolar nerve (IAN) during their surgical extraction.

Peri-implant disease pathogenesis is similar to periodontal disease pathogenesis resulting in production of pro-inflammatory mediators. These mediators are released during the inflammation phase, among which C-reactive protein (CRP) is one of the acute phase reactants. The aim of the study was to correlate the levels of CRP with the severity of peri-implant diseases. The present observational study was carried out from June 2022 to December 2022 in the Department of Implantology, Saveetha Dental College and Hospitals, Chennai, India. A total of 60 patients with peri-implant health (n = 20), peri-mucositis (n = 20) and peri-implantitis (n = 20) were enrolled. Unstimulated salivary samples were collected and subjected to latex agglutination assay for CRP analysis. CRP levels were then correlated with severity of peri-implant diseases. The mean CRP level in peri-implant health, peri-implant mucositis, peri-implantitis were 0.25 ± 0.36 mg/dl, 3.56 ± 0.85 mg/dl and 5.07 ± 0.74 mg/dl, respectively. Pearson correlation coefficient analysis revealed a strong positive correlation between CRP and peri-implant parameters suggesting that the CRP level increased as the severity of peri-implant disease increased. CRP level increases with severity of peri-implant diseases and there exists a positive correlation between CRP level and peri-implant parameters. Therefore, CRP can be used as a diagnostic marker for peri-implant diseases.

The success of dental implants is affected by bone quality and quantity at the dental implant site. The present study was done to assess the changes in alveolar bone level around osseointegrated dental implants over a period of 2 years among the premenopausal and postmenopausal women. This prospective clinical study was conducted among 50 female patients who reported between January 2020-June 2020 and had a single missing molar in maxillary or mandibular arch. Patients were categorized into 2 groups: premenopause patients (Group A; n = 25) and postmenopause patients (Group B; n = 25). Marginal bone loss (MBL) was recorded at baseline, 12 mo and 24 mo follow-up and compared between both the groups using independent t-test. ANOVA was done to compare MBL between different time periods. On intragroup comparison, a statistically significant difference was observed between different time periods in both Group A (P = 0.05) and Group B (P = 0.04). Also, on intergroup comparison, a statistically significant difference was observed in Group B from Group A at 12 mo and 24 mo (P < 0.05). Increase in marginal bone loss was observed among postmenopausal women. Therefore, clinicians should emphasize the need for oral hygiene maintenance among postmenopausal women for peri-implant health.

The incidence of proximal femur fractures is increasing due to aging of the population. Intramedullary nails are the mainstay of treatment for intertrochanteric hip fractures mainly due to their better biomechanical properties compared to dynamic hip screw devices, shorter operative time, and less blood loss during surgery. However intramedullary nail fixation is not devoid of complications. The purpose of this study is to look at complications related to intramedullary nailing for intertrochanteric hip fractures in a major trauma center. A retrospective study was conducted including all patients having suffered an intertrochanteric femur fracture and treated with intramedullary nails from October 1, 2020, to October 1, 2022, in the Orthopaedic Surgery Clinic. The intramedullary hip systems used were the Stryker Gamma3 Nail and the VITUS PF Nail. All complications following the postoperative period were recorded in detail. Overall, 240 patients with a mean age of 82.3 years treated with hip intramedullary devices were identified. Superior cutout of the lag screw in two patients (females 90 and 87 years old) was identified 8 and 10 weeks following initial surgery. Avascular necrosis (AVN) of the femoral head was identified in one patient (male 81 years old) which occurred 12 weeks postoperatively. All three cases were revised by replacing the nail with cemented hemiarthroplasty. Periprosthetic fractures occurred in an 88-year-old male and a 73-year-old female following an injury distal to the stem and were managed by replacing the nail with a long stem device (Long Gamma3). One case of metalwork fracture was also recorded. There are many advantages in managing intertrochanteric hip fractures with intramedullary hip devices such as shorter theater time, less blood loss, and improved biomechanical properties. However, complications such as cutout of the lag screw, AVN, and periprosthetic fracture are serious and require complex revision surgery.

Postoperative follow up after total or unicondylar knee arthroplasty (UKA) includes C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) to scan for and possibly diagnose a periprosthetic joint infection (PJI). The aim of this study was to describe the postoperative changes in CRP and ESR values after UKA and compare them with values obtained after TKA. Patients operated on between 2020 and 2022 were eligible for this retrospective study. Inclusion criteria were patients with at least 4 postoperative visits associated with blood test screening for PJI, aged > 45, with uneventful follow-up for the first 90 days. Exclusion criteria were a history of chronic inflammatory disease, revision for any reason, and readmission for any reason. Blood samples were collected on the 3rd, 15th, and 30th postoperative days and once between the 45th and the 90th day. The mean and peak values were compared between the two groups. The study included 277 patients (243 TKAs and 34 UKAs). Mean age was significantly lower in the UKA group (67.2 ± 7.5 vs. 60.0 ± 5.9). On the 3rd and the 15th postoperative day, the UKA patients had significantly lower ESR and CRP levels. The levels normalized after the first month. While the TKA patients showed higher values, the trend normalized after the 30th day. CRP and ESR values rose significantly after TKA and persisted up to the 15th day postoperatively. CRP and ESR values normalized faster in patients undergoing UKA. Patients > 65 had higher CRP and ESR values during their routine follow-ups.

Immediate function has become an accepted treatment modality for fixed restorations in completely edentulous jaws. The dental implants have gained immense popularity. A secure implant primary stability is positively associated with a successful implant integration and long term successful clinical outcome. The main aim of this study was to find the association between primary stability and bone density in implants placed in maxilla and mandible. A total of 1263 patients who had undergone implant placement from March 2020-March 2021 in Saveetha Dental College and Hospitals, Chennai, India were chosen for the study. The primary stability and bone density of these patients were collected from the hospital records. The collected data was compiled, reviewed, tabulated in Microsoft Excel sheet and entered in SPSS software for statistical analysis. In the present study, the patient aged between 28 and 37 years had undergone more implant placement (31%) with male predilection (53%). The most commonly associated primary stability was found to be 30-40 Ncm (51.37%) predominantly with D2 type of bone density (52.69%). A Chi-squared statistical test was done for primary stability and bone density and the P was found to be 0.00 (Chi-squared P < 0.05, statistically significant). The most predominant bone density was D2 associated with primary stability of 30-40 Ncm. The association between bone density and primary stability was found to be statistically significant. The present study shows a strong relationship between bone density and primary implant stability.

Whether the thoracic cage deformity in adolescent idiopathic scoliosis (AIS) can be sufficiently treated with vertebral derotation alone, has been quite controversial. Our aim is to control the hypothesis that the rib cage deformity (RCD) may be adequately corrected when only vertebral derotation is applied. We studied retrospectively patients treated for AIS with posterior spinal fusion without costoplasty. The RCD was assessed on lateral radiographs by rib index (RI). The correction of RI after surgery was calculated. Of the 103 patients that were finally included in our study, 29 patients (22 females and 7 males; mean age, 14.5 ± 2.1 years) represented Group A (Harrington rod instrumentation - no derotation), while 74 patients (61 females and 13 males; mean age, 14.1 ± 2.4 years) were operated with either a full pedicle screw system or a hybrid construct with hooks and pedicle screws (Group B-derotation). RI was significantly corrected after surgery in both groups. RI was significantly greater in Group A after surgery. Whatsoever, the correction of RI, thereby the RCD correction, did not significantly differ among groups. In conclusion, it cannot be suggested by the present study that vertebral derotation alone can offer an absolute correction of the deformity of the thoracic cage in patients with Lenke Type 1 AIS, and it seems also that the development of RCD may not exclusively result from the spinal deformity, thus questions can be further raised regarding scoliogeny per se.