Pub Date : 2023-05-01DOI: 10.4103/jioh.jioh_248_22
R. Mohandas, Subhashree Mohapatra, Mary Oshin, Shubhangi Hajare
Aim: Besides chewable tobacco and alcohol consumption, development of head and neck squamous cell carcinoma (HNSCC) has also been linked to human papillomavirus (HPV) infection, particularly HPV16. A significant number of publications have shed light on the etiopathogenesis, molecular mechanism, and prognosis of HPV-associated HNSCC. The current bibliographic review aimed to identify and analyze the top 100 most cited articles on HPV-associated HNSCC, to guide future researchers by highlighting the most cited previous publications. Materials and Methods: A comprehensive search of bibliographic databases was performed by two independent reviewers, using medical sub-heading terms like “HPV-induced HNSCC” in several combinations. All types of published studies were included in this bibliographic analysis. The top-100 most cited articles were then identified, tabulated, and analyzed to extract the various bibliometric details. Results: The total number of citation was 19,570 (range from 11 to 1,773). The article with highest number of citation (1,773) was published in 2008 in the “Journal of Clinical Oncology.” Maximum publications originated from the United States of America. Conclusion: This article identifies the top-100 most influential articles on HPV-induced HNSCC and recognizes the evolution of knowledge through leading researchers as they guide today’s clinical decision making and future research prospects.
目的:除了咀嚼烟草和酒精消费，头颈部鳞状细胞癌(HNSCC)的发展也与人类乳头瘤病毒(HPV)感染有关，特别是HPV16。大量的出版物已经阐明了hpv相关HNSCC的发病机制、分子机制和预后。当前的文献综述旨在识别和分析hpv相关HNSCC中被引用最多的100篇文章，通过突出被引用最多的先前出版物来指导未来的研究人员。材料和方法:两位独立的审稿人对文献数据库进行了全面的检索，使用了几种组合的医学副标题术语，如“hpv诱导的HNSCC”。所有类型的已发表的研究都包括在这个书目分析中。然后对引用次数最多的前100篇文章进行识别、制表和分析，以提取各种文献计量学细节。结果:总被引数为19570篇(11 ~ 1773篇)。被引用次数最多的文章(1773次)发表在2008年的《Journal of Clinical Oncology》上。大部分出版物来自美利坚合众国。结论:本文确定了关于hpv诱导的HNSCC的前100篇最具影响力的文章，并通过领先的研究人员认识到知识的演变，因为他们指导了今天的临床决策和未来的研究前景。
{"title":"Top 100 most cited articles on human papillomavirus-induced head and neck squamous cell carcinoma: A bibliographic review","authors":"R. Mohandas, Subhashree Mohapatra, Mary Oshin, Shubhangi Hajare","doi":"10.4103/jioh.jioh_248_22","DOIUrl":"https://doi.org/10.4103/jioh.jioh_248_22","url":null,"abstract":"Aim: Besides chewable tobacco and alcohol consumption, development of head and neck squamous cell carcinoma (HNSCC) has also been linked to human papillomavirus (HPV) infection, particularly HPV16. A significant number of publications have shed light on the etiopathogenesis, molecular mechanism, and prognosis of HPV-associated HNSCC. The current bibliographic review aimed to identify and analyze the top 100 most cited articles on HPV-associated HNSCC, to guide future researchers by highlighting the most cited previous publications. Materials and Methods: A comprehensive search of bibliographic databases was performed by two independent reviewers, using medical sub-heading terms like “HPV-induced HNSCC” in several combinations. All types of published studies were included in this bibliographic analysis. The top-100 most cited articles were then identified, tabulated, and analyzed to extract the various bibliometric details. Results: The total number of citation was 19,570 (range from 11 to 1,773). The article with highest number of citation (1,773) was published in 2008 in the “Journal of Clinical Oncology.” Maximum publications originated from the United States of America. Conclusion: This article identifies the top-100 most influential articles on HPV-induced HNSCC and recognizes the evolution of knowledge through leading researchers as they guide today’s clinical decision making and future research prospects.","PeriodicalId":16138,"journal":{"name":"Journal of International Oral Health","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42437924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-01DOI: 10.4103/jioh.jioh_263_22
Yoshifumi Toyoshita, Yuki Kan, K. Kawanishi, S. Hara, H. Miura, H. Koshino
Aim: Masticatory and cognitive function in independent elderly people were traced for 4 years and the changes in both functions were analyzed. Materials and Methods: The study type is an observational study for 4 years. Subjects of 65 and above were selected by simple random sampling method and measured cognitive function (MMSE), oral status, and masticatory test at the first year, after 2 years, and after 4 years. The subjects were divided into three groups: subjects with maintained cognitive function for 4 years (n = 12), subjects with declined cognitive function on the time course (n = 15), and subjects with impaired cognitive function for 4 years (n = 4). The data of oral condition in each group were analyzed by Kruskal–Wallis test and Dunn–Bonferronias post hoc test (age, MMSE, masticatory ability). Statistical significance was defined at P < 0.05. Results: Remarkable change of oral status was not detected. With cutoff value as 100 mg/dL, we analyzed the combined masticatory and cognitive function changes. The subjects who had declined cognitive and maintained masticatory function were 22.6% and the subjects who had declined masticatory and maintained cognitive function were 6.5%. The rest of those independent elderly people shows various patterns. Conclusion: It was observed that the subjects who had declined cognitive and maintained masticatory function were much more than the subjects who had declined masticatory and maintained cognitive function.
{"title":"The changes of cognitive function and masticatory function for four years between community-dwelling elderly people in Japan: An observational study","authors":"Yoshifumi Toyoshita, Yuki Kan, K. Kawanishi, S. Hara, H. Miura, H. Koshino","doi":"10.4103/jioh.jioh_263_22","DOIUrl":"https://doi.org/10.4103/jioh.jioh_263_22","url":null,"abstract":"Aim: Masticatory and cognitive function in independent elderly people were traced for 4 years and the changes in both functions were analyzed. Materials and Methods: The study type is an observational study for 4 years. Subjects of 65 and above were selected by simple random sampling method and measured cognitive function (MMSE), oral status, and masticatory test at the first year, after 2 years, and after 4 years. The subjects were divided into three groups: subjects with maintained cognitive function for 4 years (n = 12), subjects with declined cognitive function on the time course (n = 15), and subjects with impaired cognitive function for 4 years (n = 4). The data of oral condition in each group were analyzed by Kruskal–Wallis test and Dunn–Bonferronias post hoc test (age, MMSE, masticatory ability). Statistical significance was defined at P < 0.05. Results: Remarkable change of oral status was not detected. With cutoff value as 100 mg/dL, we analyzed the combined masticatory and cognitive function changes. The subjects who had declined cognitive and maintained masticatory function were 22.6% and the subjects who had declined masticatory and maintained cognitive function were 6.5%. The rest of those independent elderly people shows various patterns. Conclusion: It was observed that the subjects who had declined cognitive and maintained masticatory function were much more than the subjects who had declined masticatory and maintained cognitive function.","PeriodicalId":16138,"journal":{"name":"Journal of International Oral Health","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45254540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-01DOI: 10.4103/jioh.jioh_239_22
Edward Huaman-Sarmiento, Frank Mayta-Tovalino, Arnaldo Munive-Degregori, Roman Mendoza, John Barja-Ore, Cesar Mauricio-Vilchez
Aim: To describe the use and applications of activated charcoal (AC) in the manufacture of toothpastes and mouthwashes. Materials and Methods: This narrative review conducted a search for information in the PubMed and Scopus databases. There was no restriction on language, year, or country. We use the following search strategy (“Activated Charcoal” OR “Charcoal Activated” OR “Activated CarbonFNx01”) AND TITLE-ABS-KEY (“Dentifrices” OR “Dentifrice” OR “Dental Polishes” OR “Polishes Dental” OR “Toothpastes” OR “Toothpaste” OR “Mouthwashes” OR “Mouth Rinse” OR “Mouth Rinses” OR “Rinse Mouth” OR “Rinses Mouth” OR “Mouth Bath” OR “Bath Mouth” OR “Baths Mouth” OR “Mouth Baths” OR “Mouth Wash” OR “Wash Mouth”). Results: The literature has so far shown that there are certain changes in the morphology of the enamel surface after tooth brushing with AC. AC is a highly porous compound that can exchange ions through nanopores, adhere to the enamel, and remove stains because it can absorb pigments from the tooth surface. Conclusion: Toothpastes or mouthwashes with AC have a potential whitening effect that affects the color and the surface roughness of the teeth.
{"title":"Uses and applications of activated charcoal in the manufacture of toothpastes and oral rinses: A narrative review","authors":"Edward Huaman-Sarmiento, Frank Mayta-Tovalino, Arnaldo Munive-Degregori, Roman Mendoza, John Barja-Ore, Cesar Mauricio-Vilchez","doi":"10.4103/jioh.jioh_239_22","DOIUrl":"https://doi.org/10.4103/jioh.jioh_239_22","url":null,"abstract":"Aim: To describe the use and applications of activated charcoal (AC) in the manufacture of toothpastes and mouthwashes. Materials and Methods: This narrative review conducted a search for information in the PubMed and Scopus databases. There was no restriction on language, year, or country. We use the following search strategy (“Activated Charcoal” OR “Charcoal Activated” OR “Activated CarbonFNx01”) AND TITLE-ABS-KEY (“Dentifrices” OR “Dentifrice” OR “Dental Polishes” OR “Polishes Dental” OR “Toothpastes” OR “Toothpaste” OR “Mouthwashes” OR “Mouth Rinse” OR “Mouth Rinses” OR “Rinse Mouth” OR “Rinses Mouth” OR “Mouth Bath” OR “Bath Mouth” OR “Baths Mouth” OR “Mouth Baths” OR “Mouth Wash” OR “Wash Mouth”). Results: The literature has so far shown that there are certain changes in the morphology of the enamel surface after tooth brushing with AC. AC is a highly porous compound that can exchange ions through nanopores, adhere to the enamel, and remove stains because it can absorb pigments from the tooth surface. Conclusion: Toothpastes or mouthwashes with AC have a potential whitening effect that affects the color and the surface roughness of the teeth.","PeriodicalId":16138,"journal":{"name":"Journal of International Oral Health","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45672799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-01DOI: 10.4103/jioh.jioh_237_22
José Viteri-Ruiz, J. Parise-Vasco, C. Montesinos-Guevara
Aim: Dental implants have been shown to be a safe alternative for the replacement of missing teeth since they present few complications. These are related, among other elements, to the type of connection with which the abutments and attachments are joined to the implant. For this reason, in this study we performed an overview of systematic reviews with FRISBEE methodology on the use of internal connections compared to external connections of dental implants for the treatment of single, partial, or total rehabilitation. Materials and Methods: We performed a systematic search in the Epistemonikos database. We extracted data from the included systematic reviews, reanalyzed data of primary studies, and generated a summary of findings table. We used RevMan 5.3 and GRADEpro for data analysis and data presentation. Eleven systematic reviews were included after full-text screening, which had thirty-three clinical trials. Results: The outcomes were analyzed: mechanical complication (RR: 0.64), biological complications (RR: 1.01), survival (RR: 0.99), and mean marginal bone loss (MD: 0.3 mm lower). Conclusion: The use of internal connections in dental implants could lead to less marginal bone loss and fewer mechanical complications than implants with external connections, however, the confidence in the effect is limited due to a low certainty of evidence for both outcomes. Additionally, results show that different implant connections do not have an impact on dental implant survival and biological complication rates, with a moderate and low certainty of evidence, respectively.
{"title":"Effectiveness of internal connections compared with external connections for the treatment of single, partial, or total dental implants rehabilitation: Overview of reviews","authors":"José Viteri-Ruiz, J. Parise-Vasco, C. Montesinos-Guevara","doi":"10.4103/jioh.jioh_237_22","DOIUrl":"https://doi.org/10.4103/jioh.jioh_237_22","url":null,"abstract":"Aim: Dental implants have been shown to be a safe alternative for the replacement of missing teeth since they present few complications. These are related, among other elements, to the type of connection with which the abutments and attachments are joined to the implant. For this reason, in this study we performed an overview of systematic reviews with FRISBEE methodology on the use of internal connections compared to external connections of dental implants for the treatment of single, partial, or total rehabilitation. Materials and Methods: We performed a systematic search in the Epistemonikos database. We extracted data from the included systematic reviews, reanalyzed data of primary studies, and generated a summary of findings table. We used RevMan 5.3 and GRADEpro for data analysis and data presentation. Eleven systematic reviews were included after full-text screening, which had thirty-three clinical trials. Results: The outcomes were analyzed: mechanical complication (RR: 0.64), biological complications (RR: 1.01), survival (RR: 0.99), and mean marginal bone loss (MD: 0.3 mm lower). Conclusion: The use of internal connections in dental implants could lead to less marginal bone loss and fewer mechanical complications than implants with external connections, however, the confidence in the effect is limited due to a low certainty of evidence for both outcomes. Additionally, results show that different implant connections do not have an impact on dental implant survival and biological complication rates, with a moderate and low certainty of evidence, respectively.","PeriodicalId":16138,"journal":{"name":"Journal of International Oral Health","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48550954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-01DOI: 10.4103/jioh.jioh_240_22
Deepika Katyal, R. Jain, G. Sankar, Arya S. Prasad
Aim: Enamel demineralization around orthodontic brackets due to the formation of cariogenic biofilms can be prevented by modifying the adhesive/primers with certain antimicrobials. The aim of this study was to evaluate the antimicrobial, cytotoxic, and mechanical properties of a novel chitosan-modified (CH) orthodontic primer and compare it with a control primer. Materials and Methods: This in-vitro study involved two groups (Group A: CH-modified primer and Group B: control primer). Antibacterial properties against Streptococcus mutans were evaluated using the agar well-diffusion technique to measure the zone of inhibition, and minimum inhibitory concentration (MIC) was evaluated using the two-fold diffusion technique. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) fibroblast assay was done to evaluate the cytotoxicity. After bonding brackets on extracted natural teeth the shear bond strength (SBS), contact angle (CA), and adhesive remnant index (ARI) were evaluated for both groups. Statistical analysis was done using SPSS software and the independent t-test and Mann–Whitney test were performed. Results: The CH primer when compared to the control primer had higher zone of inhibition values and lower MIC value. MTT fibroblast assay showed that the cell viability percent shown by the CH primer was more in comparison to the control primer. Statistically nonsignificant differences were found between the two primers for SBS (P > 0.05), CA (P > 0.05), and ARI (P > 0.05). Conclusion: The CH primer showed higher antibacterial activity against S. mutans at a lower inhibitory concentration, with less cytotoxicity with no effect on the SBS, CA, and ARI scores.
{"title":"Antibacterial, cytotoxic, and mechanical characteristics of a novel chitosan-modified orthodontic primer: An in-vitro study","authors":"Deepika Katyal, R. Jain, G. Sankar, Arya S. Prasad","doi":"10.4103/jioh.jioh_240_22","DOIUrl":"https://doi.org/10.4103/jioh.jioh_240_22","url":null,"abstract":"Aim: Enamel demineralization around orthodontic brackets due to the formation of cariogenic biofilms can be prevented by modifying the adhesive/primers with certain antimicrobials. The aim of this study was to evaluate the antimicrobial, cytotoxic, and mechanical properties of a novel chitosan-modified (CH) orthodontic primer and compare it with a control primer. Materials and Methods: This in-vitro study involved two groups (Group A: CH-modified primer and Group B: control primer). Antibacterial properties against Streptococcus mutans were evaluated using the agar well-diffusion technique to measure the zone of inhibition, and minimum inhibitory concentration (MIC) was evaluated using the two-fold diffusion technique. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) fibroblast assay was done to evaluate the cytotoxicity. After bonding brackets on extracted natural teeth the shear bond strength (SBS), contact angle (CA), and adhesive remnant index (ARI) were evaluated for both groups. Statistical analysis was done using SPSS software and the independent t-test and Mann–Whitney test were performed. Results: The CH primer when compared to the control primer had higher zone of inhibition values and lower MIC value. MTT fibroblast assay showed that the cell viability percent shown by the CH primer was more in comparison to the control primer. Statistically nonsignificant differences were found between the two primers for SBS (P > 0.05), CA (P > 0.05), and ARI (P > 0.05). Conclusion: The CH primer showed higher antibacterial activity against S. mutans at a lower inhibitory concentration, with less cytotoxicity with no effect on the SBS, CA, and ARI scores.","PeriodicalId":16138,"journal":{"name":"Journal of International Oral Health","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46273612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-01DOI: 10.4103/jioh.jioh_242_22
Durairaj Bala Anusha, G. Prathima, M. Suganya, M. Kavitha, Gem Ezhumalai
Aim: TheraCal PT is a newer dual-cured resin-modified calcium silicate material with comparable biological properties to Biodentine. However, its bond strength to the dentin substrate is not known, especially for its use in primary teeth. Hence, the current study aimed to evaluate and compare the shear bond strength of two pulp capping materials, Biodentine and TheraCal PT in primary molars. Materials and Methods: In this experimental study, 28 non-carious human primary molars, which were nearing exfoliation, retained, or for orthodontic purposes, were extracted and collected. Using simple random sampling, they were randomly allocated into two groups with n = 14 in each group. Following occlusal flattening, cylindrical plastic tubes were stabilized and filled with TheraCal PT in group A and Biodentine in group B. All samples were incubated, subjected to universal testing machine, and analyzed under stereomicroscope for assessing the modes of failure. The statistical methods used were Independent t test, frequency, percentage (%), and Chi-square for intergroup comparison. The level of significance was kept at 0.05. Results: Significant differences in modes of failure were observed between TheraCal PT and Biodentine groups with P = 0.041. The modes of failure observed were mostly adhesive in group A compared with group B. The mean values of shear bond strength observed for groups A and B were 5.1 ± 3.5 and 3.1 ± 1.2 MPa, respectively. Conclusion: The shear bond strength observed for TheraCal PT was found to be comparable to that of Biodentine in primary molars.
{"title":"Evaluation of shear bond strength of TheraCal PT and Biodentine in primary molars: In vitro study","authors":"Durairaj Bala Anusha, G. Prathima, M. Suganya, M. Kavitha, Gem Ezhumalai","doi":"10.4103/jioh.jioh_242_22","DOIUrl":"https://doi.org/10.4103/jioh.jioh_242_22","url":null,"abstract":"Aim: TheraCal PT is a newer dual-cured resin-modified calcium silicate material with comparable biological properties to Biodentine. However, its bond strength to the dentin substrate is not known, especially for its use in primary teeth. Hence, the current study aimed to evaluate and compare the shear bond strength of two pulp capping materials, Biodentine and TheraCal PT in primary molars. Materials and Methods: In this experimental study, 28 non-carious human primary molars, which were nearing exfoliation, retained, or for orthodontic purposes, were extracted and collected. Using simple random sampling, they were randomly allocated into two groups with n = 14 in each group. Following occlusal flattening, cylindrical plastic tubes were stabilized and filled with TheraCal PT in group A and Biodentine in group B. All samples were incubated, subjected to universal testing machine, and analyzed under stereomicroscope for assessing the modes of failure. The statistical methods used were Independent t test, frequency, percentage (%), and Chi-square for intergroup comparison. The level of significance was kept at 0.05. Results: Significant differences in modes of failure were observed between TheraCal PT and Biodentine groups with P = 0.041. The modes of failure observed were mostly adhesive in group A compared with group B. The mean values of shear bond strength observed for groups A and B were 5.1 ± 3.5 and 3.1 ± 1.2 MPa, respectively. Conclusion: The shear bond strength observed for TheraCal PT was found to be comparable to that of Biodentine in primary molars.","PeriodicalId":16138,"journal":{"name":"Journal of International Oral Health","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43432135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-01DOI: 10.4103/jioh.jioh_194_22
Ardian Jayakusuma, Andra Rizqiawan, Septian Pradana, P. Soesilawati, T. Tran, D. Kamadjaja
Aim: Uncontrolled bone resorption after tooth extraction can cause a loss in alveolar bone dimension, which has an impact on alveolar bone preservation during dental implant treatment. Alpha-mangostin contained in mangosteen peel extract can reduce alveolar bone resorption while speeding up the bone formation process. This study determined whether the administration of α-mangostin decreases Interleukin-6 (IL-6) and increases Bone Sialoprotein (BSP) in the inflammatory process. Materials and Methods: The following four groups were subjected to an in-vitro assay to compare variations in the expression of inflammatory markers IL-6 and osteogenic markers BSP in LPS-induced cell line 7F2 cells before being administered α-mangostin. The bone sialoprotein (BSP), which is used as the osteogenesis marker of the effects of α-mangostin, is examined. Lipopolysaccharides (LPS) are employed in cell line 7F2 cultures of osteoblast cells to produce inflammatory effects. Real-time PCR was used to monitor the expression of genes related to inflammation and osteogenesis. Result: The Real-time PCR results showed that LPS can increase the expression of IL-6 by (15.12 ± 2.70), the administration of α-mangostin and LPS + α-mangostin can decrease the expression of IL-6 by (0.12 ± 0.04) and (0.25 ± 0.01). BSP expression increased in the provision of LPS and LPS + α-mangostin by (1.44 ± 0.33) and (3.13 ± 1.36), while in the administration of α-mangostin decreased by (0.96 ± 0.24). Conclusion: Alpha-mangostin has a potential effect to decrease the expression of the IL-6 gene and increase the expression of the BSP gene.
{"title":"Alpha-mangostin post-induction of lipopolysaccharides on interleukin-6 and bone sialoprotein expression in osteoblast cells: An experimental in vitro study","authors":"Ardian Jayakusuma, Andra Rizqiawan, Septian Pradana, P. Soesilawati, T. Tran, D. Kamadjaja","doi":"10.4103/jioh.jioh_194_22","DOIUrl":"https://doi.org/10.4103/jioh.jioh_194_22","url":null,"abstract":"Aim: Uncontrolled bone resorption after tooth extraction can cause a loss in alveolar bone dimension, which has an impact on alveolar bone preservation during dental implant treatment. Alpha-mangostin contained in mangosteen peel extract can reduce alveolar bone resorption while speeding up the bone formation process. This study determined whether the administration of α-mangostin decreases Interleukin-6 (IL-6) and increases Bone Sialoprotein (BSP) in the inflammatory process. Materials and Methods: The following four groups were subjected to an in-vitro assay to compare variations in the expression of inflammatory markers IL-6 and osteogenic markers BSP in LPS-induced cell line 7F2 cells before being administered α-mangostin. The bone sialoprotein (BSP), which is used as the osteogenesis marker of the effects of α-mangostin, is examined. Lipopolysaccharides (LPS) are employed in cell line 7F2 cultures of osteoblast cells to produce inflammatory effects. Real-time PCR was used to monitor the expression of genes related to inflammation and osteogenesis. Result: The Real-time PCR results showed that LPS can increase the expression of IL-6 by (15.12 ± 2.70), the administration of α-mangostin and LPS + α-mangostin can decrease the expression of IL-6 by (0.12 ± 0.04) and (0.25 ± 0.01). BSP expression increased in the provision of LPS and LPS + α-mangostin by (1.44 ± 0.33) and (3.13 ± 1.36), while in the administration of α-mangostin decreased by (0.96 ± 0.24). Conclusion: Alpha-mangostin has a potential effect to decrease the expression of the IL-6 gene and increase the expression of the BSP gene.","PeriodicalId":16138,"journal":{"name":"Journal of International Oral Health","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46241279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Saud Alotaibi, Arub Albatil, Abdullah Almalki, T. Shyagali
Aim: Temporary anchorage devices (TADs) have become the routine treatment tools for orthodontic treatment. The aim of this study was to assess the knowledge about TADs among the undergraduate students of Saudi Arabia. Materials and Methods: A cross-sectional web-based questionnaire was sent to 301 undergraduate dental students across different dental colleges in Saudi Arabia from third year to internship. This prevalidated 21-item questionnaire was sent through Google Form to different dental student groups. The questionnaire included details related to demography, knowledge related to TADs, and the role of continuing dental education in building the knowledge related to TADs. Descriptive statistical analysis and the chi-square test were used to evaluate the difference in the response to the questions among the different years of undergraduate students. Results: Approximately 88% of the interns could recognize that TADs are the Implants for skeletal anchorage and 57.8% defined TADs as “Implants for skeletal anchoring. Approximately 51.8% of the respondents felt that their knowledge was obtained from their undergraduate orthodontic studies. Sixty-one percent of the respondents stated their inability to diagnose cases that would benefit from orthodontic TADs. Most of the dental students from different years preferred the introduction of the TADs in the fifth-year curriculum. There existed a significant difference between the responses given by different-year dental students (P < 0.05). Conclusion: Internship students had comparatively better knowledge regarding TADs than the undergraduate students. This warrants the need to incorporate the new techniques and treatment modalities in the undergraduate orthodontic curriculum.
{"title":"Knowledge and perception toward orthodontic skeletal temporary anchorage devices among undergraduate dental students in Saudi Arabia","authors":"Saud Alotaibi, Arub Albatil, Abdullah Almalki, T. Shyagali","doi":"10.4103/jioh.jioh_28_23","DOIUrl":"https://doi.org/10.4103/jioh.jioh_28_23","url":null,"abstract":"Aim: Temporary anchorage devices (TADs) have become the routine treatment tools for orthodontic treatment. The aim of this study was to assess the knowledge about TADs among the undergraduate students of Saudi Arabia. Materials and Methods: A cross-sectional web-based questionnaire was sent to 301 undergraduate dental students across different dental colleges in Saudi Arabia from third year to internship. This prevalidated 21-item questionnaire was sent through Google Form to different dental student groups. The questionnaire included details related to demography, knowledge related to TADs, and the role of continuing dental education in building the knowledge related to TADs. Descriptive statistical analysis and the chi-square test were used to evaluate the difference in the response to the questions among the different years of undergraduate students. Results: Approximately 88% of the interns could recognize that TADs are the Implants for skeletal anchorage and 57.8% defined TADs as “Implants for skeletal anchoring. Approximately 51.8% of the respondents felt that their knowledge was obtained from their undergraduate orthodontic studies. Sixty-one percent of the respondents stated their inability to diagnose cases that would benefit from orthodontic TADs. Most of the dental students from different years preferred the introduction of the TADs in the fifth-year curriculum. There existed a significant difference between the responses given by different-year dental students (P < 0.05). Conclusion: Internship students had comparatively better knowledge regarding TADs than the undergraduate students. This warrants the need to incorporate the new techniques and treatment modalities in the undergraduate orthodontic curriculum.","PeriodicalId":16138,"journal":{"name":"Journal of International Oral Health","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48624089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-01DOI: 10.4103/jioh.jioh_193_22
M. Jaber, Asok Mathew, E. Elameen
Aim: The styloid process (SP) is often considered elongated when it is longer than 33 mm. The aim of this study is to assess the prevalence of the elongated styloid process (ESP) among dental patients and the role of dental pathology as a possible etiological factor. Materials and Methods: In total, 2000 consecutive panoramic radiographs of normal people were retrieved from the College of Dentistry, Ajman University, Ajman, UAE, during the 2-year study period. Two calibrated observers evaluated the radiographs to minimize interobserver bias and error. A caliper was used to measure the length (in millimeters of the ESPs directly on the radiographs from the caudal margin of the tympanic plate to the tip of the SP). The ESP was considered present when the measurements were ≥30 mm. Results: This study indicates that the prevalence of the ESP was about 6.9% among the patients who attended the dental school clinic. Of the 2000 panoramic radiographs reviewed, ESP could be measured in 100 cases at least on one side. There was a significant difference between distributions on the left and right sides. The distribution also depends significantly on age and gender. The incidence of related symptoms was higher than that reported in previous studies. Conclusions: The incidence of ESP among dental patients was estimated to be 6.9%, more prevalent among the elderly compared to the young people and bilateral. Odds ratio (OR) in favor of developing ESP in males is 2.378 times more than that in females. In contrast, the OR in favor of having unilateral ESP in males is less than that in females by 0.284.
{"title":"A study on calcification, variability of the stylo-mandibular ligament, or styloid process with regard to clinical parameters among United Arab Emirates population","authors":"M. Jaber, Asok Mathew, E. Elameen","doi":"10.4103/jioh.jioh_193_22","DOIUrl":"https://doi.org/10.4103/jioh.jioh_193_22","url":null,"abstract":"Aim: The styloid process (SP) is often considered elongated when it is longer than 33 mm. The aim of this study is to assess the prevalence of the elongated styloid process (ESP) among dental patients and the role of dental pathology as a possible etiological factor. Materials and Methods: In total, 2000 consecutive panoramic radiographs of normal people were retrieved from the College of Dentistry, Ajman University, Ajman, UAE, during the 2-year study period. Two calibrated observers evaluated the radiographs to minimize interobserver bias and error. A caliper was used to measure the length (in millimeters of the ESPs directly on the radiographs from the caudal margin of the tympanic plate to the tip of the SP). The ESP was considered present when the measurements were ≥30 mm. Results: This study indicates that the prevalence of the ESP was about 6.9% among the patients who attended the dental school clinic. Of the 2000 panoramic radiographs reviewed, ESP could be measured in 100 cases at least on one side. There was a significant difference between distributions on the left and right sides. The distribution also depends significantly on age and gender. The incidence of related symptoms was higher than that reported in previous studies. Conclusions: The incidence of ESP among dental patients was estimated to be 6.9%, more prevalent among the elderly compared to the young people and bilateral. Odds ratio (OR) in favor of developing ESP in males is 2.378 times more than that in females. In contrast, the OR in favor of having unilateral ESP in males is less than that in females by 0.284.","PeriodicalId":16138,"journal":{"name":"Journal of International Oral Health","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48779857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-01DOI: 10.4103/jioh.jioh_235_22
Lamiaa M. Moharam, R. Afifi
Aim: To assess the effect of multiple layers application of different adhesive systems on the microshear bond strength (μSBS) of dentin with and without thermocycling. Materials and Methods: Two hundred forty sound human premolars had their enamel surfaces removed to expose even surfaces of dentin. The teeth were mounted in acrylic resin blocks and then assigned arbitrarily into four main groups (n = 60) representing the investigated adhesives (a self-etch [SE] adhesive, a total-etch [TE] adhesive, and a multimode [MM] adhesive used in TE and SE modes). Individually, the main groups were equally alienated into three subgroups (n = 20), each representing the number of the applied adhesive layers (one layer [1L], two layers [2L], and three layers [3L]). Then, each respective subgroup was divided subsequently into two equal divisions with n = 10 each according to thermocycling (with and without thermocycling). Each occlusal surface received three composite microrods. Prepared specimens were reserved in distilled water at temperature of 37°C until the μSBS test was performed after 24 h or after thermocycling for 3000 cycles at 5°C–55°C water bath. Results: A three-way analysis of variance (ANOVA) disclosed that multilayer application, adhesive type, and thermocycling showed a significant statistical impact on μSBS. The 1L, 2L, and 3L groups showed a statistically significant difference between the groups. The 3L groups showed the highest μSBS, whereas 1L groups recorded the least μSBS. Within the adhesive groups, a statistically significant difference was evident. The highest μSBS was recorded for TE, whereas SE recorded the least μSBS. Thermocycling (TC) has a statistically significant effect on μSBS and “no-thermocycling” (T0) groups recorded higher μSBS than thermocycled groups. Conclusion: Multilayer application of the tested adhesives had the potential to increase dentin μSBS.
{"title":"Influence of adhesive application method and thermocycling on the bonding performance of different adhesive systems to dentin","authors":"Lamiaa M. Moharam, R. Afifi","doi":"10.4103/jioh.jioh_235_22","DOIUrl":"https://doi.org/10.4103/jioh.jioh_235_22","url":null,"abstract":"Aim: To assess the effect of multiple layers application of different adhesive systems on the microshear bond strength (μSBS) of dentin with and without thermocycling. Materials and Methods: Two hundred forty sound human premolars had their enamel surfaces removed to expose even surfaces of dentin. The teeth were mounted in acrylic resin blocks and then assigned arbitrarily into four main groups (n = 60) representing the investigated adhesives (a self-etch [SE] adhesive, a total-etch [TE] adhesive, and a multimode [MM] adhesive used in TE and SE modes). Individually, the main groups were equally alienated into three subgroups (n = 20), each representing the number of the applied adhesive layers (one layer [1L], two layers [2L], and three layers [3L]). Then, each respective subgroup was divided subsequently into two equal divisions with n = 10 each according to thermocycling (with and without thermocycling). Each occlusal surface received three composite microrods. Prepared specimens were reserved in distilled water at temperature of 37°C until the μSBS test was performed after 24 h or after thermocycling for 3000 cycles at 5°C–55°C water bath. Results: A three-way analysis of variance (ANOVA) disclosed that multilayer application, adhesive type, and thermocycling showed a significant statistical impact on μSBS. The 1L, 2L, and 3L groups showed a statistically significant difference between the groups. The 3L groups showed the highest μSBS, whereas 1L groups recorded the least μSBS. Within the adhesive groups, a statistically significant difference was evident. The highest μSBS was recorded for TE, whereas SE recorded the least μSBS. Thermocycling (TC) has a statistically significant effect on μSBS and “no-thermocycling” (T0) groups recorded higher μSBS than thermocycled groups. Conclusion: Multilayer application of the tested adhesives had the potential to increase dentin μSBS.","PeriodicalId":16138,"journal":{"name":"Journal of International Oral Health","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49588340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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