Aim: This study aimed to examine the correlation between serum vitamin D (25-hydroxyvitamin D [25(OH)D]) and the transmembrane Toll-like receptor (TLR) 4 expression on CD11b+ cells in systemic lupus erythematosus (SLE) saliva. Materials and Methods: A cross-sectional study was conducted on 30 SLE patients who regularly visited to rheumatology clinic and met the following criteria: no systemic diseases, no smoking, no drinking and use of oral contraceptives, no steroid and immunosuppressant medications, no pregnancy, no wearing of dentures, and orthodontic appliances. The subject’s blood samples were taken for electrochemiluminescence immunoassay analyzer methods of examining 25(OH)D level. Full unstimulated whole saliva collection for the measurement of TLR4 expression. The descriptive demographic data, the chi-square, t test, and linear regression (95% confidence level) were used to analyze the association between blood 25(OH)D concentrations and immune cells expressing TLR4 in saliva CD11b+ cells. Results: SLE subjects had an average blood concentration of 25(OH)D of 9.9 ± 4.6 ng/mL. in saliva CD11b+ cells, TLR4 expression was 26.0 ± 20.9%. r = 0.473 and P < 0.05 indicated a correlation between the saliva CD11b+ cells expressing TLR4 and the serum level of 25(OH)D. Only 25(OH)D predicted TLR4 expression of the saliva CD11b+ cells. Conclusions: TLR4 expression of Saliva CD11b+ cells correlated with the concentrations of serum 25(OH)D in SLE. Hence, vitamin D/25(OH)D may control the immune response of SLE patients’ oral cavity.
目的:探讨血清维生素D(25-羟基维生素D [25(OH)D])与系统性红斑狼疮(SLE)唾液CD11b+细胞跨膜toll样受体(TLR) 4表达的关系。材料与方法:对30例定期到风湿病门诊就诊的SLE患者进行横断面研究，符合以下标准:无全身性疾病、不吸烟、不饮酒、不使用口服避孕药、不使用类固醇及免疫抑制剂、未怀孕、不佩戴假牙、不使用正畸器具。取受试者血样，采用电化学发光免疫分析法检测25(OH)D水平。采集全唾液，测定TLR4的表达。采用描述性人口统计学数据、卡方检验、t检验和线性回归(95%置信水平)分析血液25(OH)D浓度与唾液CD11b+细胞中表达TLR4的免疫细胞之间的关系。结果:SLE患者25(OH)D的平均血药浓度为9.9±4.6 ng/mL。在唾液CD11b+细胞中，TLR4的表达率为26.0±20.9%。r = 0.473, P < 0.05表明唾液中表达TLR4的CD11b+细胞与血清25(OH)D水平呈正相关。只有25(OH)D能预测唾液CD11b+细胞的TLR4表达。结论:SLE患者唾液CD11b+细胞TLR4表达与血清25(OH)D浓度相关。因此，维生素D/25(OH)D可能控制SLE患者口腔的免疫反应。
{"title":"TLR4 expression in the saliva of systemic lupus erythematosus correlated with the serum vitamin D/25-hydroxyvitamin D: A cross-sectional study","authors":"Hendri Susanto, D. Ernawati, Awalia","doi":"10.4103/jioh.jioh_61_22","DOIUrl":"https://doi.org/10.4103/jioh.jioh_61_22","url":null,"abstract":"Aim: This study aimed to examine the correlation between serum vitamin D (25-hydroxyvitamin D [25(OH)D]) and the transmembrane Toll-like receptor (TLR) 4 expression on CD11b+ cells in systemic lupus erythematosus (SLE) saliva. Materials and Methods: A cross-sectional study was conducted on 30 SLE patients who regularly visited to rheumatology clinic and met the following criteria: no systemic diseases, no smoking, no drinking and use of oral contraceptives, no steroid and immunosuppressant medications, no pregnancy, no wearing of dentures, and orthodontic appliances. The subject’s blood samples were taken for electrochemiluminescence immunoassay analyzer methods of examining 25(OH)D level. Full unstimulated whole saliva collection for the measurement of TLR4 expression. The descriptive demographic data, the chi-square, t test, and linear regression (95% confidence level) were used to analyze the association between blood 25(OH)D concentrations and immune cells expressing TLR4 in saliva CD11b+ cells. Results: SLE subjects had an average blood concentration of 25(OH)D of 9.9 ± 4.6 ng/mL. in saliva CD11b+ cells, TLR4 expression was 26.0 ± 20.9%. r = 0.473 and P < 0.05 indicated a correlation between the saliva CD11b+ cells expressing TLR4 and the serum level of 25(OH)D. Only 25(OH)D predicted TLR4 expression of the saliva CD11b+ cells. Conclusions: TLR4 expression of Saliva CD11b+ cells correlated with the concentrations of serum 25(OH)D in SLE. Hence, vitamin D/25(OH)D may control the immune response of SLE patients’ oral cavity.","PeriodicalId":16138,"journal":{"name":"Journal of International Oral Health","volume":"15 1","pages":"194 - 199"},"PeriodicalIF":0.7,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47289331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.4103/jioh.jioh_152_22
R. Varghese, M. Maliael, A. Subramanian
{"title":"Antibacterial activity of nanoparticle-coated orthodontic archwires: A systematic review","authors":"R. Varghese, M. Maliael, A. Subramanian","doi":"10.4103/jioh.jioh_152_22","DOIUrl":"https://doi.org/10.4103/jioh.jioh_152_22","url":null,"abstract":"","PeriodicalId":16138,"journal":{"name":"Journal of International Oral Health","volume":"1 1","pages":""},"PeriodicalIF":0.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70797139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.4103/jioh.jioh_228_21
Ari Triwardhani, AlifRakhman Effendi, I. Ardani, R. Utami
{"title":"Correlation between the variation of head type and malocclusion: A Scooping Review","authors":"Ari Triwardhani, AlifRakhman Effendi, I. Ardani, R. Utami","doi":"10.4103/jioh.jioh_228_21","DOIUrl":"https://doi.org/10.4103/jioh.jioh_228_21","url":null,"abstract":"","PeriodicalId":16138,"journal":{"name":"Journal of International Oral Health","volume":"1 1","pages":""},"PeriodicalIF":0.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70797458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.4103/jioh.jioh_127_22
Samah Kanzel, K. El Motayam, F. Abdelgawad
{"title":"Behavior management techniques adopted by pediatric dentists in Cairo, Egypt: A cross-sectional study","authors":"Samah Kanzel, K. El Motayam, F. Abdelgawad","doi":"10.4103/jioh.jioh_127_22","DOIUrl":"https://doi.org/10.4103/jioh.jioh_127_22","url":null,"abstract":"","PeriodicalId":16138,"journal":{"name":"Journal of International Oral Health","volume":"1 1","pages":""},"PeriodicalIF":0.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70796892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.4103/jioh.jioh_115_22
A. Abdou, R. Ashraf, Heba Badra
{"title":"Efficiency of orange oil solvent combined with disinfectants and bioactive glass (BAG) on the cleanness of root canal after endodontic retreatment: An in vitro study","authors":"A. Abdou, R. Ashraf, Heba Badra","doi":"10.4103/jioh.jioh_115_22","DOIUrl":"https://doi.org/10.4103/jioh.jioh_115_22","url":null,"abstract":"","PeriodicalId":16138,"journal":{"name":"Journal of International Oral Health","volume":"11 1","pages":""},"PeriodicalIF":0.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70797235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.4103/jioh.jioh_154_22
Gaurav Patri, Kotni Sheetal, P. Pradhan, Pratik Agrawal, S. Lata
{"title":"Comparative evaluation of the antibacterial efficacy of herbal agents as intracanal medicaments individually or in combination with chitosan: An in vitro RTPCR study","authors":"Gaurav Patri, Kotni Sheetal, P. Pradhan, Pratik Agrawal, S. Lata","doi":"10.4103/jioh.jioh_154_22","DOIUrl":"https://doi.org/10.4103/jioh.jioh_154_22","url":null,"abstract":"","PeriodicalId":16138,"journal":{"name":"Journal of International Oral Health","volume":"1 1","pages":""},"PeriodicalIF":0.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70797746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"3D printing in orthodontics: A narrative review","authors":"A. Subramanian, S. Harikrishnan","doi":"10.4103/jioh.jioh_83_22","DOIUrl":"https://doi.org/10.4103/jioh.jioh_83_22","url":null,"abstract":"","PeriodicalId":16138,"journal":{"name":"Journal of International Oral Health","volume":"103 1","pages":""},"PeriodicalIF":0.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70798310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
I. Azhar, RaniaG Syaharani, VanyaS Smeer, Multazan Multazan
{"title":"Polyether ether ketones (PEEK): Properties and applications as implants for alternative dentistry materials: A narrative review","authors":"I. Azhar, RaniaG Syaharani, VanyaS Smeer, Multazan Multazan","doi":"10.4103/jioh.jioh_10_22","DOIUrl":"https://doi.org/10.4103/jioh.jioh_10_22","url":null,"abstract":"","PeriodicalId":16138,"journal":{"name":"Journal of International Oral Health","volume":"1 1","pages":""},"PeriodicalIF":0.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70797173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.4103/jioh.jioh_159_22
Saleh H Alwadei, Abdulrahman Ali Hattan, Khalid Faqihi, Ali S Alhawiatan, Farhan Alwadei, A. Alwadei
{"title":"Prevalence of malocclusion and orthodontic treatment needs among Saudi primary school male children aged 6–12 years: A cross-sectional study","authors":"Saleh H Alwadei, Abdulrahman Ali Hattan, Khalid Faqihi, Ali S Alhawiatan, Farhan Alwadei, A. Alwadei","doi":"10.4103/jioh.jioh_159_22","DOIUrl":"https://doi.org/10.4103/jioh.jioh_159_22","url":null,"abstract":"","PeriodicalId":16138,"journal":{"name":"Journal of International Oral Health","volume":"1 1","pages":""},"PeriodicalIF":0.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70797355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.4103/jioh.jioh_234_21
N. Rai, Shobana Shetty, Ravi Gupta
{"title":"Comparative evaluation of the microleakage of Cention N and glass ionomer cements in open-sandwich class II restorations—An in vitro study","authors":"N. Rai, Shobana Shetty, Ravi Gupta","doi":"10.4103/jioh.jioh_234_21","DOIUrl":"https://doi.org/10.4103/jioh.jioh_234_21","url":null,"abstract":"","PeriodicalId":16138,"journal":{"name":"Journal of International Oral Health","volume":"1 1","pages":""},"PeriodicalIF":0.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70797506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：