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Oxidative Status and Thiol/Disulfide Homeostasis Are Changed During 75 g Oral Glucose Tolerance Test over a Five-Hour Period 75年期间氧化状态和硫醇/二硫化物稳态的变化 g五小时内的口服葡萄糖耐量测试
IF 1.9 4区 医学 Q2 SURGERY Pub Date : 2022-06-01 DOI: 10.1080/08941939.2022.2084189
Z. K. Kıraz, Ezgi Kar, F. Kar, E. Kocatürk, M. Kebapçı, İ. Ö. Alatas, S. Uslu
Abstract Background Oral glucose loading may affect oxidative status during oral glucose tolerance test (OGTT). We aimed to investigate how oxidant and antioxidant markers and thiol/disulfide parameters change during OGTT. Methods OGTT was performed to 42 volunteers who were considered risk of type 2 diabetes and were divided into three groups (normoglycemic, prediabetes, diabetes) according glucose levels during OGTT. Glucose, insulin, c-peptide, total antioxidant status (TAS), total oxidant status (TOS), total thiol and native thiol were investigated with auto-anaylzer for five-hours period. Results Decrease of TAS and increase of TOS levels began with the increase in glucose and insulin levels. The increase of TAS started at third hour and reached the highest levels at fifth hour. OSI levels were higher at fourth hour than fasting and first hours in normoglycemic and diabetes groups. In the prediabetic group, TAS were higher than the other groups, TOS peak was at the second hour (p < 0.05). Native thiol and total thiol levels showed variable course during OGTT, both parameters increased at the end of the process (p < 0.05). Disulfide levels showed an increase trend but it was not statistically different in normoglycemic and diabetes groups. In prediabetes group, second hour disulfide level was lower than fasting state and disulfide was significantly increased at third, fourth and fifth hours and fifth hour disulfide level was also higher than fasting. Conclusion Oxidative stress parameters and thiol/disulfide balance were found to deteriorate within five-hours after glucose loading in all groups. These results indicates that oxidative stress occurs during OGTT.
背景口服葡萄糖负荷可能影响口服葡萄糖耐量试验(OGTT)中的氧化状态。我们的目的是研究氧化和抗氧化标志物和硫醇/二硫参数在OGTT过程中的变化。方法对42例有2型糖尿病危险的志愿者进行OGTT,根据OGTT期间血糖水平分为血糖正常组、糖尿病前期组和糖尿病组。葡萄糖、胰岛素、c肽、总抗氧化状态(TAS)、总氧化状态(TOS)、总硫醇和天然硫醇用自动分析仪测定5小时。结果TAS降低,TOS升高始于葡萄糖和胰岛素水平升高。TAS在第3小时开始增加,第5小时达到最高水平。在血糖正常和糖尿病组中,第4小时的OSI水平高于空腹和第1小时。糖尿病前期组TAS明显高于其他各组,TOS峰值出现在第2 h (p < 0.05)。天然硫醇和总硫醇水平在OGTT过程中呈变化过程,在过程结束时两者均升高(p < 0.05)。二硫化物水平呈上升趋势,但在血糖正常组和糖尿病组中无统计学差异。前驱糖尿病组第2小时二硫化物水平低于空腹,第3、4、5小时二硫化物水平显著升高,第5小时二硫化物水平也高于空腹。结论各组小鼠在葡萄糖负荷后5h内氧化应激参数和硫醇/二硫平衡均出现恶化。这些结果表明氧化应激在OGTT过程中发生。
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引用次数: 2
The Effect of Mechanical Bowel Preparation on the Surgical Field in Laparoscopic Gynecologic Surgeries: A Prospective Randomized Controlled Trial 腹腔镜妇科手术中机械肠道准备对手术区域的影响:一项前瞻性随机对照试验
IF 1.9 4区 医学 Q2 SURGERY Pub Date : 2022-05-30 DOI: 10.1080/08941939.2022.2081389
U. K. Ozturk, S. Acar, S. Akış, E. Keleş, C. Alınca, M. Api
Abstract Purpose To evaluate the effects of mechanical bowel preparation (MBP) on the intraoperative visualization of the surgical field, bowel handling, intestinal load, and overall ease of surgery in patients undergoing elective laparoscopic gynecological surgeries. Methods The patients randomized to a MBP group and a no preparation (NMBP) group. The senior surgeon remained blinded to the bowel regimen used by the patient. Intraoperative visualization of the surgical field, bowel handling, intestinal load, and overall ease of surgery were evaluated using a numeric rating scale (NRS). Results We enrolled 120 patients, of whom 109 completed the study, with 51 and 58 patients in the MBP and NMBP groups, respectively. The intraoperative visualization of the surgical field, intestinal load, and NRS scores for overall ease of surgery were better in the NMBP group (p = .03, p = .048, and p = .022, respectively). The results of the assessments also revealed no significant differences in surgical field visualization, ease of bowel handling, overall ease of surgery, or the time that patients experienced passage of flatus between obese (BMI > 30 kg/m2) and non-obese (BMI ≤ 30 kg/m2) patients in the two groups. Conclusions The current study revealed that MBP did not improve the intraoperative visualization of the surgical field or the overall ease of surgery. Moreover, MBP had no benefit when operating on patients who had a high BMI. Therefore, we do not recommend routine MBP before laparoscopic gynecological surgeries.
摘要目的评估机械肠道准备(MBP)对选择性腹腔镜妇科手术患者术中手术视野、肠道处理、肠道负荷和整体手术简易性的影响。方法将患者随机分为MBP组和非制剂组。这位资深外科医生对病人使用的肠道疗法仍然一无所知。使用数字评分量表(NRS)评估手术视野、肠道处理、肠道负荷和手术总体易程度的术中可视化。结果我们招募了120名患者,其中109人完成了研究,MBP组和NMBP组分别有51名和58名患者。NMBP组的手术视野、肠道负荷和NRS评分的术中可视化效果较好(p = .03,p = .048和p = .022)。评估结果还显示,肥胖患者(BMI>30 kg/m2)和非肥胖(BMI≤30 kg/m2)患者。结论目前的研究表明,MBP并没有改善手术视野的术中可视化或手术的整体简易性。此外,MBP在对高BMI患者进行手术时没有任何益处。因此,我们不建议在腹腔镜妇科手术前进行常规MBP。
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引用次数: 3
The Predictive Role of MMP-2, MMP-9, TIMP-1 and TIMP-2 Serum Levels in the Complete Response of the Tumor to Chemotherapy in Breast Cancer Patients MMP-2、MMP-9、TIMP-1和TIMP-2血清水平对癌症患者化疗后肿瘤完全反应的预测作用
IF 1.9 4区 医学 Q2 SURGERY Pub Date : 2022-05-30 DOI: 10.1080/08941939.2022.2080308
Kayhan Ozdemir, Ismail Zengin, G. Guney Eskiler, H. Kocer, A. Ozkan, T. Demiray, Elif Özözen Şahin
Abstract Objective We investigated the serum levels of MMPs and TIMPs in breast cancer (BC) patients to predict the response rate to/after treatment with or without neoadjuvant chemotherapy. BC is the most common cancer in women and MMPs are responsible for the breakdown of ECM proteins during organogenesis and TIMPs are restricted the ECM destruction by MMPs. However, the predictive role of MMPs and TIMPs in the treatment response of BC patients has not identified. Methods This study consisted of 96 BC patients (34 neoadjuvant treatment and 62 surgically treated) and 35 healthy individuals. ELISA was used to determine the level of MMP-2, MMP-9, TIMP-1, and TIMP-2 from serum samples of BC patients. Results The mean levels of MMP-9 and TIMP-2 were significantly increased in all BC patients at diagnosis and after chemotherapy, but MMP-2 was considerably lower at diagnosis. There was only a significant difference in the TIMP-1 levels after chemotherapy as well as HER2 and ER status in the neoadjuvant and surgically treated group. Additionally, MMP-2 and MMP-9 serum levels negatively correlated with tumor size and metastatic lymph nodes in BC patients after chemotherapy. Conclusions BC patients with high levels of MMP-9 and TIMP-2 can be used to predict the stage of the tumor and CR to chemotherapy and higher TIMP-1 serum level after chemotherapy could be related to better response to chemotherapy.
摘要目的研究癌症患者血清MMPs和TIMPs水平,以预测新辅助化疗前后的疗效。BC是女性最常见的癌症,MMPs负责器官发生过程中ECM蛋白的分解,TIMP限制了MMPs对ECM的破坏。然而,MMPs和TIMPs在BC患者治疗反应中的预测作用尚未确定。方法本研究包括96例BC患者(34例新辅助治疗,62例手术治疗)和35名健康人。ELISA用于测定BC患者血清样品中MMP-2、MMP-9、TIMP-1和TIMP-2的水平。结果所有BC患者在诊断时和化疗后MMP-9和TIMP-2的平均水平均显著升高,而MMP-2在诊断时显著降低。新辅助组和手术治疗组化疗后TIMP-1水平以及HER2和ER状态仅有显著差异。此外,化疗后BC患者血清MMP-2和MMP-9水平与肿瘤大小和转移淋巴结呈负相关。结论高MMP-9和TIMP-2水平的BC患者可用于预测肿瘤的分期和对化疗的CR,化疗后血清TIMP-1水平的升高可能与更好的化疗反应有关。
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引用次数: 3
Perioperative Complications and Postoperative Mortality in Patients of Acute Stanford Type a Aortic Dissection with Cardiac Tamponade 急性Stanford a型主动脉夹层合并心包填塞的围手术期并发症及术后死亡率
IF 1.9 4区 医学 Q2 SURGERY Pub Date : 2022-05-29 DOI: 10.1080/08941939.2022.2078022
Dong-Ze Ji, Ziyi Wu, H. Dai, Jing Yang, Xun E Zhang, J. Jin, Qingguo Li, Hao Yao
Abstract Objective The aim of the study was to analyze perioperative complications and postoperative mortality in patients of acute Stanford type A aortic dissection(ATAAD)combined with cardiac tamponade (TMP). Methods In this study, we identified a total of 242 ATAAD patients who underwent surgery from January 2016 to December 2020. Of the 242 patients, 44(18.2%) patients were combined with TMP and 198(81.8%) patients without TMP. We compared perioperative complications and postoperative mortality between the two groups. Results The postoperative mortality was significantly higher in patients with TMP (29.5% vs 14.1%, p = 0.014). The incidence of postoperative acute kidney injury (75.0% vs 51.5%, p = 0.005), acute hepatic injury (45.5% vs 20.7%, p = 0.001), cerebral infarction (27.3% vs 13.1%, p = 0.020), low cardiac output syndrome (50.0% vs 33.3%, p = 0.038) and respiratory failure (36.4% vs 22.2%, p = 0.049) in patients with TMP was significantly higher than those without TMP. Binary logistic regression analysis showed that age [odds ratio(OR) 1.063, 95% confidence interval (CI) 1.023∼1.105; p = 0.002], surgical time[odds ratio(OR)1.393, 95% confidence interval (CI) 1.006∼1.929; p = 0.046], cardiac tamponade[odds ratio(OR)3.010, 95% confidence interval (CI) 1.166∼7.767; p = 0.023], circulatory arrest time[odds ratio(OR)1.044, 95% confidence interval (CI) 1.001∼1.088; p = 0.045] were independent risk factors for postoperative mortality in ATAAD patients. Conclusions Cardiac tamponade increases the difficulty of perioperative management in ATAAD patients, the incidence of postoperative complications and postoperative mortality, which requires the cooperation of anesthesiologists, intensivists and surgeons to save and improve patients’ lives.
摘要目的分析急性Stanford A型主动脉夹层(ATAAD)合并心包填塞(TMP)患者围手术期并发症及术后死亡率。方法在本研究中,我们共确定了242例2016年1月至2020年12月接受手术治疗的ATAAD患者。242例患者中,合并TMP 44例(18.2%),不合并TMP 198例(81.8%)。比较两组患者围手术期并发症及术后死亡率。结果TMP组患者术后死亡率明显高于对照组(29.5% vs 14.1%, p = 0.014)。术后急性肾损伤(75.0% vs 51.5%, p = 0.005)、急性肝损伤(45.5% vs 20.7%, p = 0.001)、脑梗死(27.3% vs 13.1%, p = 0.020)、低心输出量综合征(50.0% vs 33.3%, p = 0.038)、呼吸衰竭(36.4% vs 22.2%, p = 0.049)发生率均显著高于非TMP组。二元logistic回归分析显示年龄[比值比(OR) 1.063, 95%可信区间(CI) 1.023 ~ 1.105;p = 0.002],手术时间[优势比(OR)1.393, 95%可信区间(CI) 1.006 ~ 1.929;p = 0.046],心包填塞[优势比(OR)3.010, 95%可信区间(CI) 1.166 ~ 7.767;p = 0.023],循环停止时间[优势比(OR)1.044, 95%可信区间(CI) 1.001 ~ 1.088;p = 0.045]是ATAAD患者术后死亡的独立危险因素。结论心包填塞增加了ATAAD患者围手术期管理的难度,增加了术后并发症的发生率和术后死亡率,需要麻醉医师、重症监护医师和外科医师的共同努力才能挽救和改善患者的生命。
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引用次数: 0
Constructing and Validating a Prognosis Predictive Nomogram for Cancer-Specific Survival in Rectal Cancer Patients Receiving Preoperative Radiotherapy 构建和验证直肠癌术前放疗患者肿瘤特异性生存的预后预测图
IF 1.9 4区 医学 Q2 SURGERY Pub Date : 2022-05-26 DOI: 10.1080/08941939.2022.2078021
Yunjie Shi, Xinxing Li, Xukun Zhang, Shengyun Wang, Jun Pu, Lihua Zhang, Zhiqian Hu
Abstract Background A predictive tool is required to identify the cancer-specific survival in rectal cancer (RC) patients who have opted to receive preoperative radiotherapy. Methods A database containing the data on RC patients’ records of Surveillance, Epidemiology, and End Results (SEER) receiving surgery during 2000–2014 was selected. All patients received neoadjuvant radiotherapy (NR). The correlation of clinicopathological parameters was analyzed using the Chi-square test and the survival risk factors were analyzed using the Cox proportional hazards analysis (univariate and multivariate). Finally, the nomogram was developed and validated to visually represent an accurate prediction of the probability of 3- and 5-year cancer-specific survival (CSS) based on the screened variables of the cohort. Results 11,499 rectal cancer patients were included in our cohort. Patients’ records were randomly allocated to either the development or validation cohorts based on an equal ratio (1:1). Performing the multivariate Cox regression analysis incorporating these variables in the development cohort determined 11 independent prognostic factors. Statistically significant differences were recorded among subgroups using log-rank tests, which confirmed the appropriateness and acceptability of factor stratifications. Then, the nomogram was constructed and its concordance index (C-index) values in the development cohort (0.720) and validation cohort (0.717) were evaluated to be higher (P<0.05) than those of the AJCC stage (0.631 and 0.633 respectively). Also, the 3-year AUC values of this nomogram were higher than those of the AJCC stage in both the development cohort (0.746 vs. 0.631) and the validation cohort (0.745 vs. 0.640). Using DCA curves, the predictive potential of the currently developed nomogram outperformed the conventional AJCC staging system. Conclusion The nomogram model might be a more reliable tool to predict prognosis accurately in rectal cancer patients receiving preoperative radiotherapy.
摘要背景需要一种预测工具来确定选择术前放疗的癌症(RC)直肠患者的癌症特异性生存率。方法选择一个包含2000-2004年接受手术的RC患者的监测、流行病学和最终结果(SEER)记录数据的数据库。所有患者均接受新辅助放射治疗。使用卡方检验分析临床病理参数的相关性,并使用Cox比例风险分析(单变量和多变量)分析生存风险因素。最后,根据队列的筛选变量,开发并验证了列线图,以直观地表示3年和5年癌症特异性生存(CSS)概率的准确预测。结果纳入队列的癌症患者11499例。根据相等的比例(1:1),将患者的记录随机分配到开发或验证队列中。在发育队列中结合这些变量进行多变量Cox回归分析,确定了11个独立的预后因素。使用对数秩检验记录了亚组之间的统计学显著差异,这证实了因素分层的适当性和可接受性。然后,构建列线图,评估其在发展队列(0.720)和验证队列(0.717)中的一致性指数(C指数)值高于AJCC阶段(分别为0.631和0.633)(P<0.05)。此外,在开发队列(0.746 vs.0.631)和验证队列(0.745 vs.0.640)中,该列线图的3年AUC值均高于AJCC分期。使用DCA曲线,目前开发的列线图预测潜力优于传统AJCC分期系统。结论列线图模型可作为准确预测癌症术前放疗患者预后的可靠工具。
{"title":"Constructing and Validating a Prognosis Predictive Nomogram for Cancer-Specific Survival in Rectal Cancer Patients Receiving Preoperative Radiotherapy","authors":"Yunjie Shi, Xinxing Li, Xukun Zhang, Shengyun Wang, Jun Pu, Lihua Zhang, Zhiqian Hu","doi":"10.1080/08941939.2022.2078021","DOIUrl":"https://doi.org/10.1080/08941939.2022.2078021","url":null,"abstract":"Abstract Background A predictive tool is required to identify the cancer-specific survival in rectal cancer (RC) patients who have opted to receive preoperative radiotherapy. Methods A database containing the data on RC patients’ records of Surveillance, Epidemiology, and End Results (SEER) receiving surgery during 2000–2014 was selected. All patients received neoadjuvant radiotherapy (NR). The correlation of clinicopathological parameters was analyzed using the Chi-square test and the survival risk factors were analyzed using the Cox proportional hazards analysis (univariate and multivariate). Finally, the nomogram was developed and validated to visually represent an accurate prediction of the probability of 3- and 5-year cancer-specific survival (CSS) based on the screened variables of the cohort. Results 11,499 rectal cancer patients were included in our cohort. Patients’ records were randomly allocated to either the development or validation cohorts based on an equal ratio (1:1). Performing the multivariate Cox regression analysis incorporating these variables in the development cohort determined 11 independent prognostic factors. Statistically significant differences were recorded among subgroups using log-rank tests, which confirmed the appropriateness and acceptability of factor stratifications. Then, the nomogram was constructed and its concordance index (C-index) values in the development cohort (0.720) and validation cohort (0.717) were evaluated to be higher (P<0.05) than those of the AJCC stage (0.631 and 0.633 respectively). Also, the 3-year AUC values of this nomogram were higher than those of the AJCC stage in both the development cohort (0.746 vs. 0.631) and the validation cohort (0.745 vs. 0.640). Using DCA curves, the predictive potential of the currently developed nomogram outperformed the conventional AJCC staging system. Conclusion The nomogram model might be a more reliable tool to predict prognosis accurately in rectal cancer patients receiving preoperative radiotherapy.","PeriodicalId":16200,"journal":{"name":"Journal of Investigative Surgery","volume":"35 1","pages":"1526 - 1535"},"PeriodicalIF":1.9,"publicationDate":"2022-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41463486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
What Are the Characteristics of Papillary Thyroid Microcarcinoma Prone to High-Volume Lateral Lymph Node Metastasis? - An Analysis of 2981 Consecutive Cases 乳头状甲状腺微小癌易发生大体积侧淋巴结转移的特点是什么?-2981例连续病例分析
IF 1.9 4区 医学 Q2 SURGERY Pub Date : 2022-05-24 DOI: 10.1080/08941939.2022.2075494
Luying Gao, Xiaoyi Li, Chunhao Liu, Ruifeng Liu, Xinlong Shi, Liyuan Ma, Hao Zhao, Yu Xia, Yuxin Jiang
Abstract Purpose To identify candidate factors for predicting high-volume lateral lymph node metastasis (LLNM) in papillary thyroid microcarcinoma (PTMC). Methods We retrospectively studied 2981 patients with PTMC who underwent thyroidectomy from 2013 to 2016. LLNM was identified by histopathology. Patients with different LLNM statuses were compared according to clinical, sonographic and pathological parameters. A multivariate logistic model was established to predict high-volume LLNM (number of metastatic lymph nodes >5). Results High-volume LLNM of PTMC was independently associated with age < 40 years (OR = 1.791, P = 0.023), male sex (OR = 2.401, p = 0.001), tumor size > 0.5 cm (OR = 4.839, p < 0.001), extrathyroidal extension (OR = 2.097, p = 0.007) and microcalcification (OR = 2.894, p = 0.002). These five factors were incorporated together to develop a multivariate analysis, which showed good predictive ability (AUC = 0.78, 95% CI 0.72–0.83), with a sensitivity of 80.0% and a specificity of 61.4%. Moreover, more level II or V lateral regions were involved in patients with high-volume LLNM than in those with small-volume LLNM (69.2% vs. 25.0%, p < 0.001; 10.8% vs. 4.7%, p < 0.001). Conclusion Multilevel LLNM tended to be more common in patients with PTMC who had high-volume LLNM. The high-volume LLNM rates of patients with PTMC with age < 40 years, male sex, tumor size > 0.5 cm, extrathyroidal extension and microcalcification were relatively higher than those without. These findings may be useful for identifying patients at higher high-volume LLNM risk who may require more aggressive treatment or intensive follow-up management.
摘要目的确定预测甲状腺乳头状微癌(PTMC)高容量侧淋巴结转移(LLNM)的候选因素。方法回顾性研究2013年至2016年接受甲状腺切除术的2981例PTMC患者。LLNM通过组织病理学鉴定。根据临床、超声和病理参数对不同LLNM状态的患者进行比较。建立了一个多变量逻辑模型来预测高容量LLNM(转移淋巴结数>5)。结果PTMC的高容量LLNM与年龄<40独立相关 年(OR=1.791,P = 0.023),男性(OR=2.401,p = 0.001),肿瘤大小>0.5 cm(OR=4.839,p  0.5 cm、甲状腺外延伸和微钙化相对高于无甲状腺外延伸者。这些发现可能有助于识别高容量LLNM风险的患者,这些患者可能需要更积极的治疗或强化随访管理。
{"title":"What Are the Characteristics of Papillary Thyroid Microcarcinoma Prone to High-Volume Lateral Lymph Node Metastasis? - An Analysis of 2981 Consecutive Cases","authors":"Luying Gao, Xiaoyi Li, Chunhao Liu, Ruifeng Liu, Xinlong Shi, Liyuan Ma, Hao Zhao, Yu Xia, Yuxin Jiang","doi":"10.1080/08941939.2022.2075494","DOIUrl":"https://doi.org/10.1080/08941939.2022.2075494","url":null,"abstract":"Abstract Purpose To identify candidate factors for predicting high-volume lateral lymph node metastasis (LLNM) in papillary thyroid microcarcinoma (PTMC). Methods We retrospectively studied 2981 patients with PTMC who underwent thyroidectomy from 2013 to 2016. LLNM was identified by histopathology. Patients with different LLNM statuses were compared according to clinical, sonographic and pathological parameters. A multivariate logistic model was established to predict high-volume LLNM (number of metastatic lymph nodes >5). Results High-volume LLNM of PTMC was independently associated with age < 40 years (OR = 1.791, P = 0.023), male sex (OR = 2.401, p = 0.001), tumor size > 0.5 cm (OR = 4.839, p < 0.001), extrathyroidal extension (OR = 2.097, p = 0.007) and microcalcification (OR = 2.894, p = 0.002). These five factors were incorporated together to develop a multivariate analysis, which showed good predictive ability (AUC = 0.78, 95% CI 0.72–0.83), with a sensitivity of 80.0% and a specificity of 61.4%. Moreover, more level II or V lateral regions were involved in patients with high-volume LLNM than in those with small-volume LLNM (69.2% vs. 25.0%, p < 0.001; 10.8% vs. 4.7%, p < 0.001). Conclusion Multilevel LLNM tended to be more common in patients with PTMC who had high-volume LLNM. The high-volume LLNM rates of patients with PTMC with age < 40 years, male sex, tumor size > 0.5 cm, extrathyroidal extension and microcalcification were relatively higher than those without. These findings may be useful for identifying patients at higher high-volume LLNM risk who may require more aggressive treatment or intensive follow-up management.","PeriodicalId":16200,"journal":{"name":"Journal of Investigative Surgery","volume":"35 1","pages":"1519 - 1525"},"PeriodicalIF":1.9,"publicationDate":"2022-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41818432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Elevated Serum Procalcitonin to Predict Severity and Prognosis of Extensive Burns 血清降钙素原升高预测大面积烧伤的严重程度和预后
IF 1.9 4区 医学 Q2 SURGERY Pub Date : 2022-05-15 DOI: 10.1080/08941939.2022.2073489
Zhaoxing Liu, Dawei Li, Xinzhu Liu, Bohan Zhang, Yu Zang, Jinglong Ma, Wen Zhang, Yuezeng Niu, Chuan'an Shen
Abstract Purpose To analyze the factors affecting the elevation of serum procalcitonin (PCT) in patients with extensive burns, and explore its potential value in evaluating the severity and prognosis. Methods Clinical data of 139 patients with extensive burns admitted to our burn center from January 2014 to December 2019 were retrospectively analyzed. Spearman’s Rank correlation coefficient was used to analyze the factors influencing the elevated PCT levels. The predictive power of PCT for death was evaluated by receiver operating characteristic (ROC) and multiple logistic regression analysis. Results 72 cases exhibited elevated serum PCT concentrations during the shock phase, but none of them had obvious signs of infection. PCT level in the shock phase was positively correlated with burn area, depth, degree of inhalation injury, delay in fluid resuscitation, APACHE II, and SOFA scores. The peak values of PCT during shock and infection phases were significantly higher in the non-survivors than in the survivors. The areas under the ROC curve for predicting death were 0.788 and 0.926, respectively, and 5.4 ng/mL (OR = 5.33) and 8.5 ng/mL (OR = 14.49) were the high-risk thresholds for death prediction. Conclusions Serum PCT level in the shock phase is a potential indicator for evaluating the severity of burns, while the PCT level during the infection period can be used as an early warning indicator for severe systemic infection. High levels of PCT peaks during the shock and infection periods indicate an increased risk of poor prognosis, and targeted treatment is required accordingly.
摘要目的分析影响大面积烧伤患者血清降钙素原(PCT)升高的因素,探讨其在评估严重程度和预后方面的潜在价值。方法回顾性分析2014年1月至2019年12月我院烧伤中心收治的139例大面积烧伤患者的临床资料。采用Spearman秩相关系数分析影响PCT水平升高的因素。PCT对死亡的预测能力通过受试者操作特征(ROC)和多元逻辑回归分析进行评估。结果72例患者在休克期血清PCT浓度升高,但均无明显感染迹象。休克期PCT水平与烧伤面积、深度、吸入性损伤程度、液体复苏延迟、APACHE II和SOFA评分呈正相关。在休克和感染阶段,非幸存者的PCT峰值明显高于幸存者。ROC曲线下预测死亡的面积分别为0.788和0.926,以及5.4 ng/mL(或 = 5.33)和8.5 ng/mL(或 = 14.49)是预测死亡的高危阈值。结论休克期血清PCT水平是评估烧伤严重程度的潜在指标,而感染期PCT水平可作为严重全身感染的早期预警指标。休克和感染期间PCT峰值的高水平表明预后不良的风险增加,因此需要有针对性的治疗。
{"title":"Elevated Serum Procalcitonin to Predict Severity and Prognosis of Extensive Burns","authors":"Zhaoxing Liu, Dawei Li, Xinzhu Liu, Bohan Zhang, Yu Zang, Jinglong Ma, Wen Zhang, Yuezeng Niu, Chuan'an Shen","doi":"10.1080/08941939.2022.2073489","DOIUrl":"https://doi.org/10.1080/08941939.2022.2073489","url":null,"abstract":"Abstract Purpose To analyze the factors affecting the elevation of serum procalcitonin (PCT) in patients with extensive burns, and explore its potential value in evaluating the severity and prognosis. Methods Clinical data of 139 patients with extensive burns admitted to our burn center from January 2014 to December 2019 were retrospectively analyzed. Spearman’s Rank correlation coefficient was used to analyze the factors influencing the elevated PCT levels. The predictive power of PCT for death was evaluated by receiver operating characteristic (ROC) and multiple logistic regression analysis. Results 72 cases exhibited elevated serum PCT concentrations during the shock phase, but none of them had obvious signs of infection. PCT level in the shock phase was positively correlated with burn area, depth, degree of inhalation injury, delay in fluid resuscitation, APACHE II, and SOFA scores. The peak values of PCT during shock and infection phases were significantly higher in the non-survivors than in the survivors. The areas under the ROC curve for predicting death were 0.788 and 0.926, respectively, and 5.4 ng/mL (OR = 5.33) and 8.5 ng/mL (OR = 14.49) were the high-risk thresholds for death prediction. Conclusions Serum PCT level in the shock phase is a potential indicator for evaluating the severity of burns, while the PCT level during the infection period can be used as an early warning indicator for severe systemic infection. High levels of PCT peaks during the shock and infection periods indicate an increased risk of poor prognosis, and targeted treatment is required accordingly.","PeriodicalId":16200,"journal":{"name":"Journal of Investigative Surgery","volume":"35 1","pages":"1510 - 1518"},"PeriodicalIF":1.9,"publicationDate":"2022-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43705090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Minimally Invasive Surgery for Cervical Cancer: Should We Look beyond Squamous Cell Carcinoma? 癌症宫颈微创手术:我们应该超越鳞状细胞癌吗?
IF 1.9 4区 医学 Q2 SURGERY Pub Date : 2022-05-12 DOI: 10.1080/08941939.2022.2075495
A. Giannini, O. D’Oria, V. Chiantera, C. Margioula-Siarkou, M. C. Di Donna, S. Terzic, Z. Sleiman, A. Laganà
aDepartment of Medical and surgical sciences and translational Medicine, PhD Course in “translational Medicine and oncology”, sapienza university, rome, Italy; bunit of gynecologic oncology, arnas "Civico – Di Cristina – Benfratelli", Palermo, Italy; cDepartment of Health Promotion, Mother and Child Care, Internal Medicine and Medical specialties (ProMIse), university of Palermo, Palermo, Italy; d2nd academic Department of obstetrics and gynaecology, Hippokration general Hospital, aristotle university of thessaloniki, thessaloníki, greece; eDepartment of surgical, oncological and oral sciences (Di.Chir.on.s.), university of Palermo, Palermo, Italy; fDepartment of Medicine, school of Medicine, nazarbayev university, nur-sultan, Kazakhstan; gDepartment of obstetrics and gynecology, lebanese american university, Beirut, lebanon
a意大利罗马萨皮恩扎大学医学和外科科学与转化医学系,“转化医学与肿瘤学”博士课程;妇科肿瘤学教授,arnas“Civico–Di Cristina–Benfratelli”,意大利巴勒莫;c意大利巴勒莫巴勒莫大学健康促进、母婴保健、内科和医学专业系;希腊塞萨洛尼基亚里士多德大学Hippokration综合医院第2产科;意大利巴勒莫巴勒莫大学外科、肿瘤学和口腔科学系;哈萨克斯坦努尔苏丹纳扎尔巴耶夫大学医学院医学系;g黎巴嫩贝鲁特黎巴嫩裔美国大学妇产科
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引用次数: 14
A Proposed Nomogram Model for Recurrence of Non-Muscle Invasive Bladder Carcinoma 非肌肉浸润性膀胱癌复发的诺模图模型
IF 1.9 4区 医学 Q2 SURGERY Pub Date : 2022-05-12 DOI: 10.1080/08941939.2022.2071507
K. Tsapakidis, M. Liontos, M. Tolia, N. Tsoukalas
aDepartment of oncology, university Hospital of larissa, Medical school, university of thessaly, larissa, greece; bDepartment of Clinical therapeutics, “alexandra” Hospital, national and Kapodistrian university of athens, athens, greece; cDepartment of radiotherapy, school of Medicine, university of Crete, Heraklion, greece; dDepartment of oncology, 401 general Military Hospital of athens, athens, greece
a希腊拉里萨市萨里大学医学院拉里萨大学医院肿瘤科;b临床治疗学系,“亚历山德拉”医院,国立和希腊雅典Kapodistrian大学;c希腊伊拉克利翁克里特大学医学院放射治疗系;d肿瘤科,雅典401总军事医院,雅典,希腊
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引用次数: 0
Prostate Cancer Nomograms Are Still Alive 前列腺癌nomograph仍然存在
IF 1.9 4区 医学 Q2 SURGERY Pub Date : 2022-05-09 DOI: 10.1080/08941939.2022.2071508
D. Castellani
Prostate cancer (PCa) is the second most common cancer worldwide, with an estimated incidence of 30.7 new cases per 100,000 men in 2020 [1]. The highest incidence rates were reported in Northern and Western Europe, the Caribbean, Australia, and New Zealand [2]. PCa shows a steady increase with age but a non-neglectable number of men aged 20–50 years are currently diagnosed and die of PCa, with an estimated worldwide number of deaths of 2770 men in 2020 in this range of age [1]. Li et. al established nomograms to predict overall and cancer-specific survival in PCa patients aged <50 years at diagnosis [3]. The authors used data from The Surveillance, Epidemiology, and End Results (SEER) database between 2004 and 2016. 8259 patients were included and randomly divided into two groups (training and validation group) at a ratio of 7:3. In multivariate analysis, race, marital status, summary stage, American Joint Committee on Cancer (AJCC) stage, lymph node stage, biopsy Gleason score, and treatment were significantly associated with overall survival, whereas AJCC stage, lymph node stage, biopsy Gleason score, and treatment were associated with cancer-specific survival. The above variables were used to build nomograms aiming to predict 5-, 8-, and 10-year overall and cancer-specific survival. Using receiver operating characteristic curve analysis, the authors found that the discriminative ability of their nomograms was moderately accurate in predicting overall survival and highly accurate in predicting cancer-specific survival. The performance of nomograms was confirmed by the validation group. Nomograms are currently widely used in urologic oncology, particularly in the decision-making process and patient counseling [4]. In the diagnostic phase, nomograms using clinical parameters are useful to assess the risk of clinically significant PCa at biopsy [4], and nomograms that include multiparametric magnetic resonance imaging data have been recently introduced [5,6]. Post-diagnosis decision-making is a crucial aspect in PCa patients, mostly to stratify the risk of progression and to offer advice on the possible management of clinically localized disease [4]. Post-treatment prognostic nomograms were also developed for detecting patients at risk of lymph node invasion, presence of positive surgical, margin, extracapsular extension, and biochemical recurrence after radical prostatectomy [7]. Prognostic nomograms are more accurate than staging systems in predicting the progression of PCa. Being continuous prediction methods, nomograms are more appropriate to predict progression compared with staging systems, because grouping patients predisposes to reduce the predictive accuracy of a prognostic model [8]. In fact, Liu et al. confirmed that the constructed nomograms demonstrated to have a better predictive ability in predicting overall and cancer-specific survival than AJCC TNM and Gleason score [3]. Notably, their analysis failed to show any influence of base
前列腺癌(PCa)是全球第二大常见癌症,预计到2020年,每10万名男性中有30.7例新发病例。据报道,发病率最高的是北欧和西欧、加勒比地区、澳大利亚和新西兰。随着年龄的增长,前列腺癌呈稳步增长趋势,但不可忽视的是,目前有20-50岁的男性被诊断并死于前列腺癌,估计到2020年,全世界这一年龄段的男性死亡人数为2770人。Li等人建立了图来预测诊断时年龄<50岁的前列腺癌患者的总生存率和癌症特异性生存率。作者使用了2004年至2016年监测、流行病学和最终结果(SEER)数据库中的数据。纳入8259例患者,按7:3的比例随机分为两组(训练组和验证组)。在多变量分析中,种族、婚姻状况、总结分期、美国癌症联合委员会(AJCC)分期、淋巴结分期、活检Gleason评分和治疗与总生存率显著相关,而AJCC分期、淋巴结分期、活检Gleason评分和治疗与癌症特异性生存率相关。以上变量用于构建旨在预测5年、8年和10年总体和癌症特异性生存的nomogram。使用受试者工作特征曲线分析,作者发现他们的nomogram鉴别能力在预测总体生存时是中等准确的,在预测癌症特异性生存时是高度准确的。经验证组确认图的性能。nomography目前广泛应用于泌尿肿瘤学,特别是在决策过程和患者咨询中。在诊断阶段,使用临床参数的x线图可用于评估活检bb0处临床显著性PCa的风险,并且最近引入了包含多参数磁共振成像数据的x线图[5,6]。诊断后决策是前列腺癌患者的一个重要方面,主要是对进展风险进行分层,并就临床局限性疾病bbb的可能管理提供建议。治疗后的预后x线图也被用于检测患者是否有淋巴结浸润、手术阳性、边缘、囊外延伸和根治性前列腺切除术后生化复发的风险。在预测前列腺癌的进展方面,预后图比分期系统更准确。作为一种连续预测方法,nomogram与分期系统相比更适合于预测病情进展,因为对患者进行分组容易降低预后模型bbb的预测准确性。事实上,Liu等人证实,构建的nomogram在预测总体和癌症特异性生存方面比AJCC TNM和Gleason评分bb0有更好的预测能力。值得注意的是,他们的分析没有显示基线前列腺特异性抗原(PSA)对预测生存率有任何影响。这可能与验证组中诊断时PSA≥20 ng/ml的大量患者(94%)有关。尽管如此,超过一半的患者活检Gleason评分≤6(55.6%),少数病例为T3-4(12.3%),有淋巴结(19.2%)或全身转移(2.0%)。Hu等人仍然使用2010 - 2015年的SEER数据库数据,在23,730名年龄小于55岁的男性中发现PSA与预后不良显著相关。作者开发了一种有效的预后图,包括PSA、婚姻状况、AJCC分期、Gleason评分和手术,以预测1年、3年和5年总生存率。这种差异可能部分与Liu的模型中纳入的患者数量较少有关,这可能导致模型过拟合。最后,Liu的nomograph缺乏系统治疗的数据,使得它不适合需要这种治疗的转移性患者。尽管存在上述局限性,但作者应该为评估非常年轻男性前列腺癌预后提供有用的工具而表示祝贺,这弥补了文献中的空白。我们希望作者希望通过建立一个桌面或手持软件来实现他们的工作,以便在日常临床实践中快速简便地应用他们的图。谱图的时代还没有结束,PCa谱图仍然存在。
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Journal of Investigative Surgery
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