Journal of Medical Biography最新文献

Treatment of castration-resistant prostate cancer is and has been a challenge. In 1957, the chemist Imre Könyves came to Sweden as a refugee from Hungary and started to work at AB Leo, a pharmaceutical company in Helsingborg. In 1961, he started to synthesize compounds where the oestrogens were linked to a mustard group by a carbamate. This resulted in estramustine phosphate, which was initially tested against mammary cancer with disappointing results. He then started a cooperation with urology professor Gösta Jönsson, Head of the Department of Urology at the Lund University Hospital, to test estramustine phosphate against prostate cancer. Jönsson started clinical estramustine phosphate tests in 1966. His studies were one-armed and consecutive, with a "favourable response" in 83% of previously untreated patients. These favourable results could not be reproduced in later randomized controlled studies suggesting that estramustine phosphate as primary treatment was not better than conventional estrogenic treatment. Conclusions: Even if the results of Gösta Jönsson's studies could not be confirmed, the subsequent randomized studies of estramustine phosphate may hide the desired action of estramustine phosphate in a subgroup of patients. It has still not been elucidated whether estramustine phosphate has effects in this subgroup of patients with ostrogen-resistant prostate cancer.

Wu Mengchao had been engaged in basic and clinical research in hepatobiliary surgery since the 1950s and is recognised as the founder and pioneer of hepatobiliary surgery in China. In his career of over 60 years, Wu performed over 16,000 operations and made numerous breakthroughs in hepatobiliary surgery, liver cancer signal transduction, immunotherapy and molecular pathology research. Wu's series of achievements have driven the innovative development of basic theoretical research on the liver in China, establishing it as a long-term international leader in the field of hepatobiliary surgery. This biography elucidates Wu's outstanding contributions to the establishment and development of Chinese hepatobiliary surgery.

The mastery of medical sciences, pharmacy, and botany can be seen in the records of Andalusian scientists. This descriptive-analytical research introduces one of the scientists of the 10th and 11th centuries AD. Medical knowledge and its affiliates are taken from the medical heritage of ancient civilizations. Andalusian scientists changed Andalusia's agricultural and economic situation by adopting new agricultural methods, especially irrigation and planting of medicinal plants. The name of Ibn Wāfid shines among Andalusian scholars. He was one of the theorists in the field of pharmacology in the Middle Ages. His practical method of treating patients is remarkable. His therapies tend to use nutritional methods more than prescribing drugs. He preferred single medications to compound ones. He insisted on curing diseases through hydrotherapy in mineral springs. While working in botany, Ibn Wāfid also specialized in medicine and pharmacy. He also benefits from the experiences of his master Zahrāwi while using the works of Galen, Aristotle, and Dioscorides. One of his honours was the establishment of several botanical gardens for the kings of the time. Ibn Wāfid's attempt at the flourishing of pharmacology, botany, and medicine can be considered a significant contribution to the visibility of these sciences in Medieval Andalusia.

An unsung hero of British ophthalmology is the largely forgotten Sir Benjamin Rycroft (1902-1967). This paper will discuss and analyse the undervalued career of this great man. Upon graduating from medical school, Rycroft became a General Practitioner. Rycroft then decided to train to become an ophthalmologist. Rycroft began his ophthalmology career in 1930s London focusing on the new ground-breaking surgery of keratoplasty (corneal grafting) before serving with distinction in the medical corps during the Second World War. He is chiefly remembered for his work after the war at the Queen Victoria Hospital in East Grinstead, Sussex, where he worked with renowned plastics surgeon Archibald McIndoe. During his time, there Rycroft became globally recognised for his skill in keratoplasty and started a campaign which radically changed the legal framework behind organ donation in the UK. Despite few knowing of him today, Rycroft is undoubtedly one of the most influential British ophthalmologists of the past century. He was for decades seen as one of the world's leading practitioners of keratoplasty and established a unit which restored sight to wounded veterans. His greatest achievement lies in his organ donation reform, which started the process of allowing organ donation to be carried out on a nationwide scale for the first time.

The work of the serial killers William Burke and William Hare, immigrant Ulstermen who came to Scotland in 1818, is well known. When they were finally caught, having murdered 16 people and sold their bodies for dissection, Hare turned King's evidence and after a dramatic trial Burke was hanged in January 1829. The notoriety of the case resulted in a crowd for Burke's public execution that is generally regarded as the largest that ever assembled in Edinburgh for a hanging, being estimated at between 25,000 and 35,000 people. A contemporary journal kept by a medical student named Thomas Hume was recently acquired by The Royal College of Surgeons of Edinburgh. It contains new information regarding a contingent of immigrant Irishmen who were present at the hanging. In the lead-up to the execution, they took up a position in front of the gallows and tried to prevent any non-Irish from approaching the area immediately in front of the gallows, a futile aim given the huge, rapidly accumulating mob. On being questioned by Hume on their motives, they said it was bad enough for Burke, 'the poor devil', to be hanged, but they feared he would be mocked and denigrated by the crowd and so they were there to keep the crowd away from him as much as they could. The Irish in Scotland at that time were a marginalised and ghettoised group who saw Burke as one of their own. Therefore, they most likely saw it as their duty to at least try and protect him during, in their view, his final and most harsh mistreatment by a society that had habitually mistreated him and them.

The papers from George Blair's war service as a prisoner of the Japanese in the Second World War are unusually complete. It is a valuable record because it is representative of those young doctors who provided most of the medical care in the camps, and also because the Taiwan camps are not well documented in the literature.

Johann Alexander Vogelsang, a pioneering figure in maxillofacial surgery, played an important role in developing this field in East Germany, particularly in Dresden. Born in 1890, Vogelsang pursued dentistry against his family's wishes, studying at several German universities before his education was interrupted by the First World War. His experiences treating facial injuries during the war significantly influenced his professional focus. After the war, he worked in Dresden, advancing maxillofacial surgery and overcoming significant challenges posed by the rise of National Socialism. Despite political repression, he continued his work, later contributing to the war effort in the Second World War. Postwar, Vogelsang was instrumental in rebuilding Dresden's dental medical infrastructure and establishing educational programs. His legacy endures through the institutions he helped build and the advancements he made in the field. This article chronicles his life, highlighting his contributions to dental and maxillofacial surgery and his lasting impact on medical practice and education in Dresden.

Although there had been many previous inklings, the field of xenobiotic metabolism (as we know it today) began with an experiment reported in the 1841 literature proclaiming that the ingestion of benzoic acid led to the subsequent excretion of hippuric acid in human urine. A metabolic transformation undertaken by a living organism. One worker involved in the early stages of this discovery was Wilhelm Keller, although very little information about him is readily available. Hopefully, this article will go some way to counter this dearth and also highlight Keller's pioneering contribution in the development of the fields of drug metabolism and xenobiochemistry.