首页 > 最新文献

Journal of Medical Ethics最新文献

英文 中文
How should institutions help clinicians to practise greener anaesthesia: first-order and second-order responsibilities to practice sustainably. 机构应该如何帮助临床医生实践更环保的麻醉:可持续实践的一级和二级责任。
IF 3.4 2区 哲学 Q1 ETHICS Pub Date : 2026-02-27 DOI: 10.1136/jme-2023-109442
Joshua Parker, Nathan Hodson, Paul Young, Clifford Shelton

There is a need for all industries, including healthcare, to reduce their greenhouse gas emissions. In anaesthetic practice, this not only requires a reduction in resource use and waste, but also a shift away from inhaled anaesthetic gases and towards alternatives with a lower carbon footprint. As inhalational anaesthesia produces greenhouse gas emissions at the point of use, achieving sustainable anaesthetic practice involves individual practitioner behaviour change. However, changing the practice of healthcare professionals raises potential ethical issues. The purpose of this paper is twofold. First, we discuss what moral duties anaesthetic practitioners have when it comes to practices that impact the environment. We argue that behaviour change among practitioners to align with certain moral responsibilities must be supplemented with an account of institutional duties to support this. In other words, we argue that institutions and those in power have second-order responsibilities to ensure that practitioners can fulfil their first-order responsibilities to practice more sustainably. The second goal of the paper is to consider not just the nature of second-order responsibilities but the content. We assess four different ways that second-order responsibilities might be fulfilled within healthcare systems: removing certain anaesthetic agents, seeking consensus, education and methods from behavioural economics. We argue that, while each of these are a necessary part of the picture, some interventions like nudges have considerable advantages.

包括医疗保健在内的所有行业都需要减少温室气体排放。在麻醉实践中,这不仅需要减少资源使用和浪费,还需要从吸入麻醉气体转向碳足迹更低的替代品。由于吸入麻醉在使用时会产生温室气体排放,实现可持续的麻醉实践需要个体从业者的行为改变。然而,改变医疗保健专业人员的做法会引发潜在的道德问题。本文的目的是双重的。首先,我们讨论了当涉及到影响环境的实践时,麻醉从业者有什么道德义务。我们认为,从业者为履行某些道德责任而进行的行为改变,必须辅之以支持这一点的机构职责。换言之,我们认为,机构和当权者负有二阶责任,以确保从业者能够履行其一阶责任,更可持续地进行实践。本文的第二个目标是不仅考虑二阶责任的性质,而且考虑其内容。我们评估了在医疗保健系统中履行二阶责任的四种不同方式:去除某些麻醉剂、寻求共识、行为经济学的教育和方法。我们认为,虽然每一项都是画面的必要组成部分,但一些干预措施,如轻推,具有相当大的优势。
{"title":"How should institutions help clinicians to practise greener anaesthesia: first-order and second-order responsibilities to practice sustainably.","authors":"Joshua Parker, Nathan Hodson, Paul Young, Clifford Shelton","doi":"10.1136/jme-2023-109442","DOIUrl":"10.1136/jme-2023-109442","url":null,"abstract":"<p><p>There is a need for all industries, including healthcare, to reduce their greenhouse gas emissions. In anaesthetic practice, this not only requires a reduction in resource use and waste, but also a shift away from inhaled anaesthetic gases and towards alternatives with a lower carbon footprint. As inhalational anaesthesia produces greenhouse gas emissions at the point of use, achieving sustainable anaesthetic practice involves individual practitioner behaviour change. However, changing the practice of healthcare professionals raises potential ethical issues. The purpose of this paper is twofold. First, we discuss what moral duties anaesthetic practitioners have when it comes to practices that impact the environment. We argue that behaviour change among practitioners to align with certain moral responsibilities must be supplemented with an account of institutional duties to support this. In other words, we argue that institutions and those in power have second-order responsibilities to ensure that practitioners can fulfil their first-order responsibilities to practice more sustainably. The second goal of the paper is to consider not just the nature of second-order responsibilities but the content. We assess four different ways that second-order responsibilities might be fulfilled within healthcare systems: removing certain anaesthetic agents, seeking consensus, education and methods from behavioural economics. We argue that, while each of these are a necessary part of the picture, some interventions like nudges have considerable advantages.</p>","PeriodicalId":16317,"journal":{"name":"Journal of Medical Ethics","volume":" ","pages":"177-184"},"PeriodicalIF":3.4,"publicationDate":"2026-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41141561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"哲学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Health sufficientarianism and health inequality. 健康充分主义与健康不平等。
IF 3.4 2区 哲学 Q1 ETHICS Pub Date : 2026-02-27 DOI: 10.1136/jme-2025-110870
Lasse Nielsen

This paper asks: If we are sufficientarians about health, then why do we care about health inequality? This is an important ethical question which should be of interest to moral philosophers as well as decision-makers, bureaucrats, and healthcare professionals. I present a generic account of health sufficientarianism and I argue that this account offers a distinctive and plausible explanation for our concern with health inequality. Central to my argument is the claim that the driver of our reasons for concern with social inequality in health is not the inequality per se, but the underlying risk of absolute health deficiency, and that this phenomenon is most directly explained by health sufficientarianism. This gives strengthened confidence in a sufficientarian approach to health justice.

本文提出的问题是:如果我们在健康问题上是充分主义者,那么我们为什么要关心健康不平等?这是一个重要的伦理问题,应该引起道德哲学家以及决策者、官僚和医疗保健专业人员的兴趣。我提出了一个关于健康充分主义的一般性解释,我认为这个解释为我们对健康不平等的关注提供了一个独特而合理的解释。我的论点的核心是,我们关注健康方面的社会不平等的原因不是不平等本身,而是绝对健康不足的潜在风险,这种现象可以用健康充足主义最直接地解释。这加强了人们对采取充分主义方法实现卫生正义的信心。
{"title":"Health sufficientarianism and health inequality.","authors":"Lasse Nielsen","doi":"10.1136/jme-2025-110870","DOIUrl":"10.1136/jme-2025-110870","url":null,"abstract":"<p><p>This paper asks: If we are sufficientarians about health, then why do we care about health inequality? This is an important ethical question which should be of interest to moral philosophers as well as decision-makers, bureaucrats, and healthcare professionals. I present a generic account of health sufficientarianism and I argue that this account offers a distinctive and plausible explanation for our concern with health inequality. Central to my argument is the claim that the driver of our reasons for concern with social inequality in health is not the inequality per se, but the underlying risk of absolute health deficiency, and that this phenomenon is most directly explained by health sufficientarianism. This gives strengthened confidence in a sufficientarian approach to health justice.</p>","PeriodicalId":16317,"journal":{"name":"Journal of Medical Ethics","volume":" ","pages":"166-169"},"PeriodicalIF":3.4,"publicationDate":"2026-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144024065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"哲学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthetic DNA and mitochondrial donation: no need for donor eggs? 合成DNA和线粒体捐赠:不需要捐赠卵子?
IF 3.4 2区 哲学 Q1 ETHICS Pub Date : 2026-02-27 DOI: 10.1136/jme-2024-110122
Adrian Villalba, Iain Brassington, Anna Smajdor, Daniela Cutas

Mitochondrial replacement therapy has been developed in order to prevent the transmission of mitochondrial mutations, yet it raises ethical concerns, particularly regarding the involvement of third-party DNA and the risks associated with donor procedures. This paper explores an alternative approach using synthetic DNA (synDNA) to construct mitochondrial organelles, thereby bypassing the need for donor oocytes and bypassing risks to donors. We argue that those who support mitochondrial replacement techniques as an ethically acceptable means of preventing the transmission of mitochondrial disease should consider the use of synthetic mitochondria as a preferable ethical alternative, should it prove technically viable. That this will be viable is more than we can demonstrate here. However, progress in synDNA technology suggests that it is not unreasonable to think that synthetic mitochondria creation is feasible, and perhaps even probable.

线粒体替代疗法是为了防止线粒体突变的传播而发展起来的,但它引起了伦理问题,特别是涉及第三方DNA和与供体程序相关的风险。本文探讨了一种使用合成DNA (synDNA)构建线粒体细胞器的替代方法,从而绕过了对供体卵母细胞的需求,并绕过了供体的风险。我们认为,那些支持线粒体替代技术作为一种道德上可接受的预防线粒体疾病传播的手段的人,应该考虑使用合成线粒体作为一种更可取的道德选择,如果它在技术上证明是可行的。这是可行的,我们在这里无法证明。然而,synDNA技术的进步表明,认为合成线粒体是可行的,甚至是可能的,并不是没有道理的。
{"title":"Synthetic DNA and mitochondrial donation: no need for donor eggs?","authors":"Adrian Villalba, Iain Brassington, Anna Smajdor, Daniela Cutas","doi":"10.1136/jme-2024-110122","DOIUrl":"10.1136/jme-2024-110122","url":null,"abstract":"<p><p>Mitochondrial replacement therapy has been developed in order to prevent the transmission of mitochondrial mutations, yet it raises ethical concerns, particularly regarding the involvement of third-party DNA and the risks associated with donor procedures. This paper explores an alternative approach using synthetic DNA (synDNA) to construct mitochondrial organelles, thereby bypassing the need for donor oocytes and bypassing risks to donors. We argue that those who support mitochondrial replacement techniques as an ethically acceptable means of preventing the transmission of mitochondrial disease should consider the use of synthetic mitochondria as a preferable ethical alternative, should it prove technically viable. That this will be viable is more than we can demonstrate here. However, progress in synDNA technology suggests that it is not unreasonable to think that synthetic mitochondria creation is feasible, and perhaps even probable.</p>","PeriodicalId":16317,"journal":{"name":"Journal of Medical Ethics","volume":" ","pages":"148-152"},"PeriodicalIF":3.4,"publicationDate":"2026-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144024086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"哲学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
'Chết phải toàn thây': belief in Vietnamese culture and its impact on organ donation. “Chết phải toàn th<e:1>”:越南文化的信仰及其对器官捐赠的影响。
IF 3.4 2区 哲学 Q1 ETHICS Pub Date : 2026-02-27 DOI: 10.1136/jme-2024-110513
Quang Thanh Nguyen, Ngoc Luong Khanh Nguyen, Thuy Minh Ha
{"title":"'Chết phải toàn thây': belief in Vietnamese culture and its impact on organ donation.","authors":"Quang Thanh Nguyen, Ngoc Luong Khanh Nguyen, Thuy Minh Ha","doi":"10.1136/jme-2024-110513","DOIUrl":"10.1136/jme-2024-110513","url":null,"abstract":"","PeriodicalId":16317,"journal":{"name":"Journal of Medical Ethics","volume":" ","pages":"209-210"},"PeriodicalIF":3.4,"publicationDate":"2026-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143255771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"哲学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Ethics of Ozempic and Wegovy. 奥兹匹克和维格维的伦理学。
IF 3.4 2区 哲学 Q1 ETHICS Pub Date : 2026-02-27 DOI: 10.1136/jme-2024-110374
Nanette Ryan, Julian Savulescu

Semaglutide, sold under the brand names of Ozempic, Rybelsus and Wegovy, is one of the most popular drugs on the market. Manufactured by Novo Nordisk, semaglutide is the newest in a family of glucagon-like peptide-1 receptor agonists used most commonly to treat type II diabetes. To date, the results of semaglutide for the treatment of type II diabetes have been overwhelmingly positive. It is for the drug's effects on appetite suppression and weight loss, however, that have led its surge in popularity, with many hailing semaglutide as the new 'miracle drug for weight loss'. Despite its popularity, both the governmental and popular reception to the drug has largely been mixed. In this paper, we address a range of ethical concerns and argue that while many are legitimate, they do not provide conclusive reason not to prescribe semaglutide for weight loss.

Semaglutide以Ozempic、Rybelsus和Wegovy等品牌出售,是市场上最受欢迎的药物之一。semaglutide由诺和诺德公司生产,是胰高血糖素样肽-1受体激动剂家族中最新的一种,最常用于治疗II型糖尿病。迄今为止,西马鲁肽治疗II型糖尿病的结果是压倒性的积极。然而,正是由于这种药物在抑制食欲和减肥方面的作用,它才受到了人们的欢迎,许多人都称赞西马鲁肽是一种新的“减肥神药”。尽管它很受欢迎,但政府和民众对这种药物的态度在很大程度上是褒贬不一的。在本文中,我们解决了一系列的伦理问题,并认为,虽然许多是合法的,他们没有提供结论性的理由不开西马鲁肽减肥。
{"title":"The Ethics of Ozempic and Wegovy.","authors":"Nanette Ryan, Julian Savulescu","doi":"10.1136/jme-2024-110374","DOIUrl":"10.1136/jme-2024-110374","url":null,"abstract":"<p><p>Semaglutide, sold under the brand names of Ozempic, Rybelsus and Wegovy, is one of the most popular drugs on the market. Manufactured by Novo Nordisk, semaglutide is the newest in a family of glucagon-like peptide-1 receptor agonists used most commonly to treat type II diabetes. To date, the results of semaglutide for the treatment of type II diabetes have been overwhelmingly positive. It is for the drug's effects on appetite suppression and weight loss, however, that have led its surge in popularity, with many hailing semaglutide as the new 'miracle drug for weight loss'. Despite its popularity, both the governmental and popular reception to the drug has largely been mixed. In this paper, we address a range of ethical concerns and argue that while many are legitimate, they do not provide conclusive reason not to prescribe semaglutide for weight loss.</p>","PeriodicalId":16317,"journal":{"name":"Journal of Medical Ethics","volume":" ","pages":"185-193"},"PeriodicalIF":3.4,"publicationDate":"2026-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143028975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"哲学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Adaptive preferences in medicine: a subjectivity-first account. 医学中的适应性偏好:主观性优先的解释。
IF 3.4 2区 哲学 Q1 ETHICS Pub Date : 2026-02-27 DOI: 10.1136/jme-2024-110469
Shadi Heidarifar

In this paper, I argue for a subjectivity-first account of health-related adaptive preferences (HRAPs). Rather than evaluating preferences in isolation, this approach shifts normative attention to how a subject's lived orientation and the world they inhabit mutually shape one another long before a clinical encounter. On this view, the normative task is to understand how HRAPs become intelligible to a subject under non-ideal conditions by focusing on two dimensions of subject formation: the ecosystemic, which concerns the patterned norms and material conditions that structure what appears viable, and the configurational, which concerns how subjects interpret and navigate these pressures within their lived orientation. Together, these dimensions explain how HRAPs emerge in ways that avoid collapsing into either paternalism or relativism.

在本文中,我主张对健康相关的适应偏好(hrap)进行主观性优先的解释。这种方法不是孤立地评估偏好,而是将规范性的注意力转移到受试者的生活取向和他们所居住的世界是如何在临床相遇之前很久就相互影响的。在这种观点下,规范性的任务是通过关注主体形成的两个维度来理解主体如何在非理想条件下理解hrap:生态系统,它关注的是构建似乎可行的模式规范和物质条件,以及配置,它关注的是主体如何在他们的生活取向中解释和驾驭这些压力。综上所述,这些维度解释了hrap是如何以避免陷入家长作风或相对主义的方式出现的。
{"title":"Adaptive preferences in medicine: a subjectivity-first account.","authors":"Shadi Heidarifar","doi":"10.1136/jme-2024-110469","DOIUrl":"https://doi.org/10.1136/jme-2024-110469","url":null,"abstract":"<p><p>In this paper, I argue for a <i>subjectivity-first</i> account of health-related adaptive preferences (HRAPs). Rather than evaluating preferences in isolation, this approach shifts normative attention to how a subject's lived orientation and the world they inhabit mutually shape one another long before a clinical encounter. On this view, the normative task is to understand how HRAPs become intelligible to a subject under non-ideal conditions by focusing on two dimensions of subject formation: the ecosystemic, which concerns the patterned norms and material conditions that structure what appears viable, and the configurational, which concerns how subjects interpret and navigate these pressures within their lived orientation. Together, these dimensions explain how HRAPs emerge in ways that avoid collapsing into either paternalism or relativism.</p>","PeriodicalId":16317,"journal":{"name":"Journal of Medical Ethics","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147317391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"哲学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ethics briefing. 道德简报。
IF 3.4 2区 哲学 Q1 ETHICS Pub Date : 2026-02-27 DOI: 10.1136/jme-2026-111727
Natalie Michaux, Tanya Brigden, Sumair Nizamuddin, Ranveig Svenning Berg
{"title":"Ethics briefing.","authors":"Natalie Michaux, Tanya Brigden, Sumair Nizamuddin, Ranveig Svenning Berg","doi":"10.1136/jme-2026-111727","DOIUrl":"https://doi.org/10.1136/jme-2026-111727","url":null,"abstract":"","PeriodicalId":16317,"journal":{"name":"Journal of Medical Ethics","volume":"52 3","pages":"211-212"},"PeriodicalIF":3.4,"publicationDate":"2026-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147317425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"哲学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Challenging the challenge: why xenotransplantation remains a necessary promise. 挑战挑战:为什么异种移植仍然是一个必要的前景。
IF 3.4 2区 哲学 Q1 ETHICS Pub Date : 2026-02-26 DOI: 10.1136/jme-2026-111862
Emilien Seizilles de Mazancourt
{"title":"Challenging the challenge: why xenotransplantation remains a necessary promise.","authors":"Emilien Seizilles de Mazancourt","doi":"10.1136/jme-2026-111862","DOIUrl":"https://doi.org/10.1136/jme-2026-111862","url":null,"abstract":"","PeriodicalId":16317,"journal":{"name":"Journal of Medical Ethics","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147307045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"哲学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Autonomy and the right not to know incidental findings arising during treatment response monitoring. 自主权和不知道治疗反应监测过程中偶然发现的权利。
IF 3.4 2区 哲学 Q1 ETHICS Pub Date : 2026-02-25 DOI: 10.1136/jme-2025-111554
Jasper Debrabander

The moral right not to know (RNTK) is predominantly grounded in autonomy. This means that the scope, strength and nature of the moral RNTK is determined in light of the ethical principle of respect for autonomy. In this paper, I will further explore the relationship between patient autonomy and the scope of the RNTK in the context of treatment response monitoring. I focus on treatment response monitoring because novel challenges can be formulated against grounding the RNTK in autonomy in this context. I will consider three accounts of patient autonomy: Beauchamp and Childress' account of patient autonomy, Weimer's evidence-responsiveness condition for patient autonomy and Pugh's account of rational autonomy. Throughout the paper, I will illustrate the implications of these accounts of patient autonomy for the scope of the RNTK by asking which incidental findings (IFs) that arise during treatment response monitoring can be autonomously refused by metastatic breast cancer patients. I will conclude that although it becomes more difficult to autonomously refuse particular IFs on Weimer and Pugh's more demanding accounts of patient autonomy in the context of treatment response monitoring, they do not make it radically impossible to autonomously refuse any IF. Given the strength of the RNTK, this provides us with a strong reason to obtain, contrary to current clinical practice, patients' consent regarding the disclosure of IFs in the context of treatment response monitoring.

不知道的道德权利(RNTK)主要建立在自主权的基础上。这意味着,道德的RNTK的范围、力量和性质是根据尊重自治的伦理原则确定的。在本文中,我将在治疗反应监测的背景下进一步探讨患者自主性与RNTK范围之间的关系。我专注于治疗反应监测,因为在这种情况下,可以制定新的挑战来反对将RNTK置于自主性中。我将考虑三种关于病人自主的说法:Beauchamp和Childress关于病人自主的说法,Weimer关于病人自主的证据反应条件,以及Pugh关于理性自主的说法。在整篇论文中,我将通过询问在治疗反应监测期间出现的哪些偶然发现(if)可以被转移性乳腺癌患者自主拒绝,来说明这些患者自主性对RNTK范围的影响。我的结论是,尽管在Weimer和Pugh对治疗反应监测背景下患者自主性的更苛刻的描述中,自主拒绝特定的IF变得更加困难,但他们并没有使自主拒绝任何IF从根本上变得不可能。考虑到RNTK的强度,这为我们提供了一个强有力的理由,与目前的临床实践相反,在治疗反应监测的背景下,获得患者对披露IFs的同意。
{"title":"Autonomy and the right not to know incidental findings arising during treatment response monitoring.","authors":"Jasper Debrabander","doi":"10.1136/jme-2025-111554","DOIUrl":"https://doi.org/10.1136/jme-2025-111554","url":null,"abstract":"<p><p>The moral right not to know (RNTK) is predominantly grounded in autonomy. This means that the scope, strength and nature of the moral RNTK is determined in light of the ethical principle of respect for autonomy. In this paper, I will further explore the relationship between patient autonomy and the scope of the RNTK in the context of treatment response monitoring. I focus on treatment response monitoring because novel challenges can be formulated against grounding the RNTK in autonomy in this context. I will consider three accounts of patient autonomy: Beauchamp and Childress' account of patient autonomy, Weimer's evidence-responsiveness condition for patient autonomy and Pugh's account of rational autonomy. Throughout the paper, I will illustrate the implications of these accounts of patient autonomy for the scope of the RNTK by asking which incidental findings (IFs) that arise during treatment response monitoring can be autonomously refused by metastatic breast cancer patients. I will conclude that although it becomes more difficult to autonomously refuse particular IFs on Weimer and Pugh's more demanding accounts of patient autonomy in the context of treatment response monitoring, they do not make it radically impossible to autonomously refuse any IF. Given the strength of the RNTK, this provides us with a strong reason to obtain, contrary to current clinical practice, patients' consent regarding the disclosure of IFs in the context of treatment response monitoring.</p>","PeriodicalId":16317,"journal":{"name":"Journal of Medical Ethics","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147307074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"哲学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Novel metalinguistic approach to declaring circulatory death in normothermic regional perfusion: a lesson from brain death. 常温区域灌注下宣布循环死亡的新元语言方法:来自脑死亡的经验教训。
IF 3.4 2区 哲学 Q1 ETHICS Pub Date : 2026-02-25 DOI: 10.1136/jme-2025-111424
William Jinwoong Choi

Recent advancements in organ procurement techniques to improve the quality of donated organs have given rise to normothermic regional perfusion (NRP), a procedure that restores blood flow to organs in patients who are declared dead by the circulatory standard. Arguments about NRP often refer to a troubling question: are NRP donors truly dead, or are they resuscitated?Such concerns about NRP draw parallels to the brain death debate: an issue that has attracted irreconcilable arguments about the nature of death. The resulting ideological gridlock seems to suggest that death is a metaphysical concept based on deeply rooted philosophical beliefs, and engaging in more intractable debates about the nature of death seems unfruitful for bioethics. In order to avoid repeating the mistakes of the brain death debate, metaphysical arguments about circulatory death should be framed under a new paradigm of metalinguistic dispute This paradigm considers how the concept of 'death' should be deployed usefully for NRP by evaluating the sociofunctional consequences of deploying death concepts for NRP while leaving the metaphysical question about death open.This paradigmatic shift from metaphysics to metalinguistics can help clinicians focus on clarifying the pragmatic and moral significance of declaring someone dead before undergoing NRP according to each patient's beliefs about death. A choice-based policy aligns with this goal by circumventing an ideological gridlock and avoiding the imposition of a single metaphysical conclusion about NRP on families with diverging beliefs about death.

最近器官获取技术的进步提高了捐赠器官的质量,这导致了常温区域灌注(NRP)的出现,这是一种恢复血液流向被循环标准宣布死亡的患者器官的程序。关于NRP的争论经常涉及一个令人不安的问题:NRP的捐赠者是真的死了,还是复活了?这种对NRP的关注与脑死亡的争论相似:这个问题引起了关于死亡本质的不可调和的争论。由此产生的意识形态僵局似乎表明,死亡是一种基于根深蒂固的哲学信仰的形而上学概念,而对死亡本质进行更棘手的辩论似乎对生命伦理学没有任何效果。为了避免重复脑死亡争论的错误,关于循环死亡的形而上学争论应该在元语言争论的新范式下进行框架,该范式考虑如何通过评估为NRP部署死亡概念的社会功能后果来有效地部署“死亡”概念,同时留下关于死亡的形而上学问题开放。这种从形而上学到元语言学的范式转变可以帮助临床医生根据每个病人对死亡的信念,专注于澄清在接受NRP之前宣布某人死亡的实用主义和道德意义。基于选择的政策通过规避意识形态的僵局,避免对对死亡有不同信仰的家庭强加关于NRP的单一形而上学结论,从而与这一目标保持一致。
{"title":"Novel metalinguistic approach to declaring circulatory death in normothermic regional perfusion: a lesson from brain death.","authors":"William Jinwoong Choi","doi":"10.1136/jme-2025-111424","DOIUrl":"https://doi.org/10.1136/jme-2025-111424","url":null,"abstract":"<p><p>Recent advancements in organ procurement techniques to improve the quality of donated organs have given rise to normothermic regional perfusion (NRP), a procedure that restores blood flow to organs in patients who are declared dead by the circulatory standard. Arguments about NRP often refer to a troubling question: are NRP donors truly dead, or are they resuscitated?Such concerns about NRP draw parallels to the brain death debate: an issue that has attracted irreconcilable arguments about the nature of death. The resulting ideological gridlock seems to suggest that death is a metaphysical concept based on deeply rooted philosophical beliefs, and engaging in more intractable debates about the nature of death seems unfruitful for bioethics. In order to avoid repeating the mistakes of the brain death debate, metaphysical arguments about circulatory death should be framed under a new paradigm of <i>metalinguistic dispute</i> This paradigm considers how the concept of 'death' should be deployed usefully for NRP by evaluating the sociofunctional consequences of deploying death concepts for NRP while leaving the metaphysical question about death open.This paradigmatic shift from metaphysics to metalinguistics can help clinicians focus on clarifying the pragmatic and moral significance of declaring someone dead before undergoing NRP according to each patient's beliefs about death. A choice-based policy aligns with this goal by circumventing an ideological gridlock and avoiding the imposition of a single metaphysical conclusion about NRP on families with diverging beliefs about death.</p>","PeriodicalId":16317,"journal":{"name":"Journal of Medical Ethics","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147307026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"哲学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Journal of Medical Ethics
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1