Tsumbedzo Nemandalali, Monde A. Nyila, T. E. Tshikalange
{"title":"Bioactivity of plants used traditionally in the treatment and management of men’s sexual health","authors":"Tsumbedzo Nemandalali, Monde A. Nyila, T. E. Tshikalange","doi":"10.4102/jomped.v8i1.260","DOIUrl":"https://doi.org/10.4102/jomped.v8i1.260","url":null,"abstract":"","PeriodicalId":16345,"journal":{"name":"Journal of Medicinal Plants for Economic Development","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141795718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Oral candidiasis is caused by Candida albicans, which is most prevalent in immunocompromised patients.Aim: The study aimed to investigate the antifungal activity of plant species used for oral candidiasis against C. albicans.Setting: The study was conducted in Aganang Local Municipality, Capricorn District, Limpopo province, South Africa.Methods: A survey was conducted using a semi-structured questionnaire supplemented with guided field walks with traditional health practitioners to gather information on medicinal plants used to treat oral candidiasis. Nine plant species (Artemisia afra Jacq. ex Willd., Blepharis subvolubilis subsp. subvolubilis C.B. Clarke, Enicostemma axillare [Lam.], Helichrysum caespititium [DC.] Harv., Solanum incanum L., Waltheria indica L., Ximenia caffra Sond. var. caffra, Ximenia caffra Sond. var. natalensis and Ziziphus mucronata Willd.) were investigated for antifungal activity. The plant material were extracted with solvents of varying polarities: acetone, dichloromethane, ethyl acetate, ethanol, hexane, methanol, and water. The Micro-dilution and bioautography assays were used to determine the antifungal activity of the plant extracts.Results: Leaf extracts of A. afra and S. incanum were more active against C. albicans with MIC values of 0.02 mg/mL. Bioautography assay demonstrated active compounds in S. incanum, W. indica and X. caffra var. caffra extracts developed in Benzene: Ethanol: Ammonia hydroxide (BEA).Conclusion: An ethnobotanical survey is a worthy starting point in selecting potential plant species for ethnopharmacological studies.Contribution: The effectiveness of oral administrations of the medicinal plants was confirmed by the excellent antifungal activity of the aqueous extracts.
背景：口腔念珠菌病是由白色念珠菌引起的，在免疫力低下的患者中最为常见。目的：该研究旨在调查用于治疗口腔念珠菌病的植物物种对白色念珠菌的抗真菌活性：研究在南非林波波省摩羯座区的阿加南地方市进行：调查采用半结构式问卷调查，并辅以传统医疗从业人员的实地指导，以收集有关用于治疗口腔念珠菌病的药用植物的信息。九种植物（Artemisia afra Jacq、var. natalensis 和 Ziziphus mucronata Willd.）进行了抗真菌活性研究。植物材料用不同极性的溶剂进行提取：丙酮、二氯甲烷、乙酸乙酯、乙醇、己烷、甲醇和水。采用微量稀释法和生物层析法测定植物提取物的抗真菌活性：结果：A. afra 和 S. incanum 的叶提取物对白僵菌更有活性，其 MIC 值为 0.02 mg/mL。生物自显影测定显示，在苯中提取的 S. incanum、W. indica 和 X. caffra var：乙醇：结论：结论：民族植物学调查是选择潜在植物物种进行民族药理学研究的出发点：水提取物的卓越抗真菌活性证实了口服药用植物的有效性。
{"title":"Ethnobotanical survey and anti-candidal activity of plant species used for oral candidiasis","authors":"D. Tlaamela, Salome Mahlo, L. Mcgaw","doi":"10.4102/jomped.v8i1.220","DOIUrl":"https://doi.org/10.4102/jomped.v8i1.220","url":null,"abstract":"Background: Oral candidiasis is caused by Candida albicans, which is most prevalent in immunocompromised patients.Aim: The study aimed to investigate the antifungal activity of plant species used for oral candidiasis against C. albicans.Setting: The study was conducted in Aganang Local Municipality, Capricorn District, Limpopo province, South Africa.Methods: A survey was conducted using a semi-structured questionnaire supplemented with guided field walks with traditional health practitioners to gather information on medicinal plants used to treat oral candidiasis. Nine plant species (Artemisia afra Jacq. ex Willd., Blepharis subvolubilis subsp. subvolubilis C.B. Clarke, Enicostemma axillare [Lam.], Helichrysum caespititium [DC.] Harv., Solanum incanum L., Waltheria indica L., Ximenia caffra Sond. var. caffra, Ximenia caffra Sond. var. natalensis and Ziziphus mucronata Willd.) were investigated for antifungal activity. The plant material were extracted with solvents of varying polarities: acetone, dichloromethane, ethyl acetate, ethanol, hexane, methanol, and water. The Micro-dilution and bioautography assays were used to determine the antifungal activity of the plant extracts.Results: Leaf extracts of A. afra and S. incanum were more active against C. albicans with MIC values of 0.02 mg/mL. Bioautography assay demonstrated active compounds in S. incanum, W. indica and X. caffra var. caffra extracts developed in Benzene: Ethanol: Ammonia hydroxide (BEA).Conclusion: An ethnobotanical survey is a worthy starting point in selecting potential plant species for ethnopharmacological studies.Contribution: The effectiveness of oral administrations of the medicinal plants was confirmed by the excellent antifungal activity of the aqueous extracts.","PeriodicalId":16345,"journal":{"name":"Journal of Medicinal Plants for Economic Development","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141810766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Antioxidants present in plant extracts prevent free radicals from causing chronic diseases in humans.Aim: The study investigated 12 medicinal plants (Kleinia longiflora DC., Berchemia discolor [Klotzsch] Hemsl., Persea americana Mill., Sansevieria hyacinthoides [L.] Druce, Dichrostachys cinerea [L.] Wright Arn, Withania somnifera Dunal [Ashgandh], Momordica balsamina L., Lonchocarpus capassa, Pappea capensis, ‘Rhus lancea L. fil’ with ‘Searsia lancea (L.F.) F.A. Barkley’ Peltophorum africanum, Maytenus heterophylla [Eckl. Zeyh.] Robson) for antioxidant activity using the qualitative and quantitative 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay.Setting: The plant species were selected from the ethnomedicinal plant database of over 300 medicinal plants used for therapeutic purposes in Limpopo province.Methods: The plant materials were extracted with solvents of various polarities such as acetone, dichloromethane (DCM), methanol, hexane, and water. The qualitative and quantitative DPPH methods were used to determine the antioxidant activities of plant extracts.Results: The yellow bands revealed the presence of antioxidant compounds against the purple background on the Thin Layer Chromatography (TLC) plates. Methanol, hexane, and water extracts of L. capassa were the most active radical scavengers in the DPPH assay among the six medicinal plants screened. Plant extracts of P. africanum showed strong antioxidant activity by inhibiting DPPH, compared with the standard ascorbic acid.Conclusion: The findings indicate that some extracts can be used as an easily accessible source of natural antioxidants.Contribution: The findings revealed that the plant species investigated displayed noteworthy antioxidant activity, which provides scientific evidence for their utilisation by traditional health practitioners to treat fungal infections.
{"title":"Antifungal and antioxidant properties of medicinal plants used against fungal infections","authors":"T. C. Machaba, Salome Mahlo, J. Eloff","doi":"10.4102/jomped.v8i1.214","DOIUrl":"https://doi.org/10.4102/jomped.v8i1.214","url":null,"abstract":"Background: Antioxidants present in plant extracts prevent free radicals from causing chronic diseases in humans.Aim: The study investigated 12 medicinal plants (Kleinia longiflora DC., Berchemia discolor [Klotzsch] Hemsl., Persea americana Mill., Sansevieria hyacinthoides [L.] Druce, Dichrostachys cinerea [L.] Wright Arn, Withania somnifera Dunal [Ashgandh], Momordica balsamina L., Lonchocarpus capassa, Pappea capensis, ‘Rhus lancea L. fil’ with ‘Searsia lancea (L.F.) F.A. Barkley’ Peltophorum africanum, Maytenus heterophylla [Eckl. Zeyh.] Robson) for antioxidant activity using the qualitative and quantitative 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay.Setting: The plant species were selected from the ethnomedicinal plant database of over 300 medicinal plants used for therapeutic purposes in Limpopo province.Methods: The plant materials were extracted with solvents of various polarities such as acetone, dichloromethane (DCM), methanol, hexane, and water. The qualitative and quantitative DPPH methods were used to determine the antioxidant activities of plant extracts.Results: The yellow bands revealed the presence of antioxidant compounds against the purple background on the Thin Layer Chromatography (TLC) plates. Methanol, hexane, and water extracts of L. capassa were the most active radical scavengers in the DPPH assay among the six medicinal plants screened. Plant extracts of P. africanum showed strong antioxidant activity by inhibiting DPPH, compared with the standard ascorbic acid.Conclusion: The findings indicate that some extracts can be used as an easily accessible source of natural antioxidants.Contribution: The findings revealed that the plant species investigated displayed noteworthy antioxidant activity, which provides scientific evidence for their utilisation by traditional health practitioners to treat fungal infections.","PeriodicalId":16345,"journal":{"name":"Journal of Medicinal Plants for Economic Development","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140092229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Phillipine K. Moale, Mildred A. Chauke, M. Mokgotho, L. Shai
{"title":"Glucose transporter 4 translocation and glucose uptake by selected traditional medicinal preparations","authors":"Phillipine K. Moale, Mildred A. Chauke, M. Mokgotho, L. Shai","doi":"10.4102/jomped.v8i1.236","DOIUrl":"https://doi.org/10.4102/jomped.v8i1.236","url":null,"abstract":"","PeriodicalId":16345,"journal":{"name":"Journal of Medicinal Plants for Economic Development","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139850810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Phillipine K. Moale, Mildred A. Chauke, M. Mokgotho, L. Shai
{"title":"Glucose transporter 4 translocation and glucose uptake by selected traditional medicinal preparations","authors":"Phillipine K. Moale, Mildred A. Chauke, M. Mokgotho, L. Shai","doi":"10.4102/jomped.v8i1.236","DOIUrl":"https://doi.org/10.4102/jomped.v8i1.236","url":null,"abstract":"","PeriodicalId":16345,"journal":{"name":"Journal of Medicinal Plants for Economic Development","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139790929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zantanta Nomnqophiso, Learnmore Kambizi, N. G. Etsassala, Felix Nchu
{"title":"Bioactivities of helichrysum cymosum cultivated in aquaponic, hydroponic and field systems","authors":"Zantanta Nomnqophiso, Learnmore Kambizi, N. G. Etsassala, Felix Nchu","doi":"10.4102/jomped.v8i1.200","DOIUrl":"https://doi.org/10.4102/jomped.v8i1.200","url":null,"abstract":"","PeriodicalId":16345,"journal":{"name":"Journal of Medicinal Plants for Economic Development","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139437176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
D. M. Tlaamela, Salome Mahlo, M. Abdalla, L. McGaw
Background: Based on high frequency index, Ximenia caffra Sond. var. natalensis was selected for further phytochemical investigation and biological assays.Aim: The study aimed to isolate the active antifungal compounds from the leaves of X. caffra var. natalensis.Setting: The ethnobotanical study was conducted in Aganang Local Municipality, Capricorn District.Methods: Acetone extract was partitioned five times with hexane, chloroform, ethyl acetate, butanol and water, respectively. Fractions were screened for antifungal activity against Candida albicans using the microplate method and bioautography assays. The structures of isolated compounds were identified using nuclear magnetic resonance (NMR) and mass spectrometry. Cytotoxicity of isolated compounds was determined using 3-(4,5-dimethylthiazol)-2,5-diphenyl tetrazolium bromide (MTT) assay.Results: Bioassay-guided fractionation of the ethyl acetate fraction led to the isolation of four compounds, out of which only two were identified. Compound 1 was identified as epigallocatechin gallate, and Compound 3 was confirmed as kaempferol-3-O-rhamnoside. Epigallocatechin gallate exhibited moderate antifungal activity with minimum inhibitory concentration (MIC) of 0.5mg/mL and less toxic to the cells with LC50 = 32.32 µg/mL.Conclusion: The antifungal activity and cytotoxicity of isolated compounds validate the use of X. caffra Sond. var. natalensis in combating oral candidiasis.Contribution: The results have shown the potential bioactivity of X. caffra Sond. var. natalensis in the treatment of oral candidiasis.
{"title":"Antifungal activity and toxicity of bioactive compounds isolated from the leaf of Ximenia caffra Sond. var. natalensis","authors":"D. M. Tlaamela, Salome Mahlo, M. Abdalla, L. McGaw","doi":"10.4102/jomped.v7i1.219","DOIUrl":"https://doi.org/10.4102/jomped.v7i1.219","url":null,"abstract":"Background: Based on high frequency index, Ximenia caffra Sond. var. natalensis was selected for further phytochemical investigation and biological assays.Aim: The study aimed to isolate the active antifungal compounds from the leaves of X. caffra var. natalensis.Setting: The ethnobotanical study was conducted in Aganang Local Municipality, Capricorn District.Methods: Acetone extract was partitioned five times with hexane, chloroform, ethyl acetate, butanol and water, respectively. Fractions were screened for antifungal activity against Candida albicans using the microplate method and bioautography assays. The structures of isolated compounds were identified using nuclear magnetic resonance (NMR) and mass spectrometry. Cytotoxicity of isolated compounds was determined using 3-(4,5-dimethylthiazol)-2,5-diphenyl tetrazolium bromide (MTT) assay.Results: Bioassay-guided fractionation of the ethyl acetate fraction led to the isolation of four compounds, out of which only two were identified. Compound 1 was identified as epigallocatechin gallate, and Compound 3 was confirmed as kaempferol-3-O-rhamnoside. Epigallocatechin gallate exhibited moderate antifungal activity with minimum inhibitory concentration (MIC) of 0.5mg/mL and less toxic to the cells with LC50 = 32.32 µg/mL.Conclusion: The antifungal activity and cytotoxicity of isolated compounds validate the use of X. caffra Sond. var. natalensis in combating oral candidiasis.Contribution: The results have shown the potential bioactivity of X. caffra Sond. var. natalensis in the treatment of oral candidiasis.","PeriodicalId":16345,"journal":{"name":"Journal of Medicinal Plants for Economic Development","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138994575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Liver diseases pose a substantial global public health challenge, encompassing conditions such as liver failure, hepatitis, cirrhosis and associated complications Safeguarding the liver becomes important as these conditions impact human health. Hepatoprotective agents play a pivotal role in mitigating liver damage caused by chemicals, drugs and toxins. Polyherbal formulations, combining botanical components from traditional medicine, offer a promising approach to addressing liver disorders. Their popularity arises from a multi-targeted strategy in treating complex diseases, marking a shift in focus toward these formulations. Aim: The study aimed to conduct a thorough review of the existing literature on the hepatoprotective activity of polyherbal formulations and provide a comprehensive overview of their mechanisms of action. This review provides the overview of the use of polyherbal formulations in the management of liver disease. Method: A systematic search of electronic databases, including : Scopus, Academia, Elsevier, Science Direct, Wiley, BioMed Central, PubMed, and Google Scholar, was conducted using a combination of keywords such as ‘polyherbal formulations’, ‘hepatoprotective’ and ‘liver diseases’. Studies published between January 2010 and April 2023 were included in the review. Results: A total of 61 articles were reviewed, and the studies showed that polyherbal formulations possess significant hepatoprotective activity against various hepatotoxic agents. The mechanisms of action of these formulations include antioxidant, antiinflammatory, antifibrotic and antiapoptotic effects. Additionally, some polyherbal formulations were found to stimulate liver regeneration, enhance bile secretion and promote detoxification processes. Conclusion: Polyherbal formulations have shown promising hepatoprotective activity, and their multitargeted approach to treating complex diseases makes them a potential alternative to conventional medicines. However, identifying the active compounds responsible for the hepatoprotective effects of these formulations and their pharmacokinetics and pharmacodynamics could provide insights into the development of new and effective drugs for liver disorders. Contribution: This article contributes to the growing body of literature on the potential of polyherbal formulations as hepatoprotective agents.
{"title":"Hepatoprotective activities of polyherbal formulations: A systematic review","authors":"Elizabeth B. Aladejana, Adebowale E. Aladejana","doi":"10.4102/jomped.v7i1.206","DOIUrl":"https://doi.org/10.4102/jomped.v7i1.206","url":null,"abstract":"Background: Liver diseases pose a substantial global public health challenge, encompassing conditions such as liver failure, hepatitis, cirrhosis and associated complications Safeguarding the liver becomes important as these conditions impact human health. Hepatoprotective agents play a pivotal role in mitigating liver damage caused by chemicals, drugs and toxins. Polyherbal formulations, combining botanical components from traditional medicine, offer a promising approach to addressing liver disorders. Their popularity arises from a multi-targeted strategy in treating complex diseases, marking a shift in focus toward these formulations. Aim: The study aimed to conduct a thorough review of the existing literature on the hepatoprotective activity of polyherbal formulations and provide a comprehensive overview of their mechanisms of action. This review provides the overview of the use of polyherbal formulations in the management of liver disease. Method: A systematic search of electronic databases, including : Scopus, Academia, Elsevier, Science Direct, Wiley, BioMed Central, PubMed, and Google Scholar, was conducted using a combination of keywords such as ‘polyherbal formulations’, ‘hepatoprotective’ and ‘liver diseases’. Studies published between January 2010 and April 2023 were included in the review. Results: A total of 61 articles were reviewed, and the studies showed that polyherbal formulations possess significant hepatoprotective activity against various hepatotoxic agents. The mechanisms of action of these formulations include antioxidant, antiinflammatory, antifibrotic and antiapoptotic effects. Additionally, some polyherbal formulations were found to stimulate liver regeneration, enhance bile secretion and promote detoxification processes. Conclusion: Polyherbal formulations have shown promising hepatoprotective activity, and their multitargeted approach to treating complex diseases makes them a potential alternative to conventional medicines. However, identifying the active compounds responsible for the hepatoprotective effects of these formulations and their pharmacokinetics and pharmacodynamics could provide insights into the development of new and effective drugs for liver disorders. Contribution: This article contributes to the growing body of literature on the potential of polyherbal formulations as hepatoprotective agents.","PeriodicalId":16345,"journal":{"name":"Journal of Medicinal Plants for Economic Development","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135266089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Acknowledgement to reviewers","authors":"Editorial Office","doi":"10.4102/jomped.v7i1.232","DOIUrl":"https://doi.org/10.4102/jomped.v7i1.232","url":null,"abstract":"No abstract available.","PeriodicalId":16345,"journal":{"name":"Journal of Medicinal Plants for Economic Development","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135365279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Scelo Mguni, Felistas Mashinya, Collette Khabo-Mmekoa, Lishweni J. Shai
Background: Zanthoxylum chalybeum Engl. is a traditional medicinal plant, which is native to Eastern and Southern Africa. Commonly known as the ‘Knob wood’, it has been used for centuries by several traditional healers in Kenya, Tanzania, Uganda, Zambia and Zimbabwe. The species is very well known to local communities by its common names such as ‘Kundanyoka’ (Shona), ‘Mjafari’ (Swahili) and ‘Ntaleyedungu’ (Uganda), and it grows naturally in the tropics and subtropics. Aim: The present review describes information on the ethnomedicinal uses, phytochemical constituents, pharmacology and toxicology of Z. chalybeum . Method: Collection of data was based on literature research from several sources including electronic databases such as Google scholar, Web of Science, Science Direct, Pubmed, books, book chapters and theses. Results: Z. chalybeum is widely used in the treatment of malaria, cancer and diabetes. Pharmacological studies revealed that crude extracts and some isolated chemical compounds from Z. chalybeum demonstrated biological activities such as antibacterial, antidiabetic and antimalarial activities. Studies in phytochemical analysis of Z. chalybeum revealed the presence of new compounds such as 6-benzo (1, 3) dioxol-5-yl-hexa-2,5 dienoic acid isobutylamide, 4-methoxy-N-(2-methoxy-phenyl)-N methyl-benzamide, N-(2-hydroxy-methyl-propyl)-3 phenyl-acrylamide and 4-(isoprenyloxy)-3-methoxy,4-deoxymethylenedioxyfagaramide. Toxicology studies revealed moderate to high toxicity, depending on the type of cells and the extraction solvent used. Conclusion: Z. chalybeum is a valued medicinal plant used in Eastern and Southern Africa. Contribution: The properties of Z. chalybeum revealed in previous studies can be used to guide research scientists in future drug formulations.
背景:Zanthoxylum chalybeum Engl。是一种传统的药用植物，原产于非洲东部和南部。它通常被称为“旋钮木”，几个世纪以来一直被肯尼亚、坦桑尼亚、乌干达、赞比亚和津巴布韦的一些传统治疗师使用。该物种因其常见的名称而为当地社区所熟知，如“Kundanyoka”(绍纳语)，“Mjafari”(斯瓦希里语)和“Ntaleyedungu”(乌干达)，它自然生长在热带和亚热带地区。前言:目的:综述了黄姜的民族医药用途、植物化学成分、药理和毒理学等方面的研究进展。方法:采用Google scholar、Web of Science、Science Direct、Pubmed等电子数据库、图书、图书章节、论文等文献资料收集数据。结果:黄芩在治疗疟疾、癌症、糖尿病等方面有广泛的应用。药理研究表明，黄樟粗提物及部分分离化合物具有抗菌、抗糖尿病、抗疟疾等生物活性。在植物化学分析中发现了6-苯并(1,3)二氧基-5-基-六-2,5二烯酸异丁酰胺、4-甲氧基-N-(2-甲氧基-苯基)-N -甲基-苯甲酰胺、N-(2-羟基-甲基-丙基)-3苯基-丙烯酰胺和4-(异戊氧基)-3-甲氧基，4-脱氧亚甲二氧基fagaramide等新化合物。毒理学研究显示，根据细胞类型和提取溶剂的不同，其毒性从中等到高不等。结论:白姜是非洲东部和南部一种珍贵的药用植物。贡献:前人研究揭示的黄樟的性质可用于指导研究人员在未来的药物配方。
{"title":"A review of Zanthoxylum chalybeum Engl: Ethnomedicinal uses, pharmacology, phytochemistry and toxicology","authors":"Scelo Mguni, Felistas Mashinya, Collette Khabo-Mmekoa, Lishweni J. Shai","doi":"10.4102/jomped.v7i1.202","DOIUrl":"https://doi.org/10.4102/jomped.v7i1.202","url":null,"abstract":"Background: Zanthoxylum chalybeum Engl. is a traditional medicinal plant, which is native to Eastern and Southern Africa. Commonly known as the ‘Knob wood’, it has been used for centuries by several traditional healers in Kenya, Tanzania, Uganda, Zambia and Zimbabwe. The species is very well known to local communities by its common names such as ‘Kundanyoka’ (Shona), ‘Mjafari’ (Swahili) and ‘Ntaleyedungu’ (Uganda), and it grows naturally in the tropics and subtropics. Aim: The present review describes information on the ethnomedicinal uses, phytochemical constituents, pharmacology and toxicology of Z. chalybeum . Method: Collection of data was based on literature research from several sources including electronic databases such as Google scholar, Web of Science, Science Direct, Pubmed, books, book chapters and theses. Results: Z. chalybeum is widely used in the treatment of malaria, cancer and diabetes. Pharmacological studies revealed that crude extracts and some isolated chemical compounds from Z. chalybeum demonstrated biological activities such as antibacterial, antidiabetic and antimalarial activities. Studies in phytochemical analysis of Z. chalybeum revealed the presence of new compounds such as 6-benzo (1, 3) dioxol-5-yl-hexa-2,5 dienoic acid isobutylamide, 4-methoxy-N-(2-methoxy-phenyl)-N methyl-benzamide, N-(2-hydroxy-methyl-propyl)-3 phenyl-acrylamide and 4-(isoprenyloxy)-3-methoxy,4-deoxymethylenedioxyfagaramide. Toxicology studies revealed moderate to high toxicity, depending on the type of cells and the extraction solvent used. Conclusion: Z. chalybeum is a valued medicinal plant used in Eastern and Southern Africa. Contribution: The properties of Z. chalybeum revealed in previous studies can be used to guide research scientists in future drug formulations.","PeriodicalId":16345,"journal":{"name":"Journal of Medicinal Plants for Economic Development","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135132407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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