Background. Ovarian cancer is a cancer with high fatality due to its symptomless nature which leads to late diagnosis. Therefore, there is an urgent need to discover genetic markers which are related to predisposition to the disease. With anti-inflammatory cytokines playing a major role in cancer predisposition, the present systematic review and meta-analysis was undertaken to evaluate the association of the interleukin-10 (IL-10) gene polymorphisms with ovarian cancer risk. Material and methods. Online databases were searched for articles dating from June 2023 until inception for studies assessing the frequencies of IL-10 polymorphisms in ovarian cancer patients and controls. The odds ratios of the genotypes alongside with their respective 95% confidence intervals were calculated under three different genetic models. Results. A total of 5 records studying the IL-10-819 C>T and IL-10-1082 G>A polymorphisms were included in the quantitative analysis. The meta-analysis suggested that the IL-10-819 C>T polymorphism was significantly associated the risk of ovarian cancer under a dominant (CT + TT vs CC) inheritance model (OR = 2.67; 95% CI = [1.17,6.12]; p = 0.02). Conclusions. The meta-analysis suggested that the T allele of the IL-10-819 C>T is associated with increased risk of ovarian cancer, but there is no statistically significant association between the IL-10-1082 G>A polymorphism and ovarian cancer. Future studies are required to further verify these results.
背景。卵巢癌是一种病死率高的癌症，由于其无症状的性质，导致较晚的诊断。因此，迫切需要发现与疾病易感性相关的遗传标记。鉴于抗炎细胞因子在癌症易感性中起着重要作用，本研究通过系统回顾和荟萃分析来评估白细胞介素-10 (IL-10)基因多态性与卵巢癌风险的关系。材料和方法。在线数据库检索了从2023年6月开始的文章，用于评估卵巢癌患者和对照组中IL-10多态性的频率。在三种不同的遗传模型下，计算了基因型的优势比及其各自的95%置信区间。共有5条记录研究了IL-10-819的C>T和IL-10-1082的G>A多态性进行了定量分析。荟萃分析显示，在显性(CT + TT vs CC)遗传模型下，IL-10-819 C>T多态性与卵巢癌风险显著相关(OR = 2.67;95% ci = [1.17,6.12];p = 0.02)。meta分析提示IL-10-819 C>T的T等位基因与卵巢癌风险增加相关，但IL-10-1082 G>A多态性与卵巢癌的相关性无统计学意义。未来的研究需要进一步验证这些结果。
{"title":"Association of the interleukin-10 (IL-10) gene polymorphisms with ovarian cancer risk: a systematic review and meta-analysis","authors":"Stavri Totou, Datis Kalali","doi":"10.20883/medical.e918","DOIUrl":"https://doi.org/10.20883/medical.e918","url":null,"abstract":"Background. Ovarian cancer is a cancer with high fatality due to its symptomless nature which leads to late diagnosis. Therefore, there is an urgent need to discover genetic markers which are related to predisposition to the disease. With anti-inflammatory cytokines playing a major role in cancer predisposition, the present systematic review and meta-analysis was undertaken to evaluate the association of the interleukin-10 (IL-10) gene polymorphisms with ovarian cancer risk.\u0000Material and methods. Online databases were searched for articles dating from June 2023 until inception for studies assessing the frequencies of IL-10 polymorphisms in ovarian cancer patients and controls. The odds ratios of the genotypes alongside with their respective 95% confidence intervals were calculated under three different genetic models.\u0000Results. A total of 5 records studying the IL-10-819 C>T and IL-10-1082 G>A polymorphisms were included in the quantitative analysis. The meta-analysis suggested that the IL-10-819 C>T polymorphism was significantly associated the risk of ovarian cancer under a dominant (CT + TT vs CC) inheritance model (OR = 2.67; 95% CI = [1.17,6.12]; p = 0.02).\u0000Conclusions. The meta-analysis suggested that the T allele of the IL-10-819 C>T is associated with increased risk of ovarian cancer, but there is no statistically significant association between the IL-10-1082 G>A polymorphism and ovarian cancer. Future studies are required to further verify these results.","PeriodicalId":16350,"journal":{"name":"Journal of Medical Science","volume":"35 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138594111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
On 5th May 2023, World Health Organization declared that COVID-19 is no longer considered a public health emergency of international concern, and various governments are closing their healthcare facilities, meticulously prepared for the world’s worst pandemic. However, the question arises of how to exit the severe phase of this pandemic responsibly. The present communication discusses the follies of being under-prepared in tackling COVID-19, particularly by the economically weaker nations, and it also outlines the necessary steps that are now needed for better management of future pandemics, with international co-operation of the developed and developing countries. More attention is needed to address the paradox of digital access in excess, but of little technical use, particularly in emergencies like that of the recent viral pandemic. If the scientific analyses of the healthcare issues been carried out correctly, their predictions and strategies supported by authentic big data, managing the pandemic could have been better. Still, it is not late and expertise developed recently can help the future generations. On the individual front, mass education, awareness of hygiene, and understanding and application of basic science, particularly in rural areas is, needed to be safer rather than depend on traditional beliefs and expect miracles, a system prevalent in developing countries.
{"title":"Perspectives for Better Health: prepare for exiting severe phase of COVID-19 pandemic","authors":"Shaima SA Miraj, Sharique A. Ali","doi":"10.20883/medical.e932","DOIUrl":"https://doi.org/10.20883/medical.e932","url":null,"abstract":"On 5th May 2023, World Health Organization declared that COVID-19 is no longer considered a public health emergency of international concern, and various governments are closing their healthcare facilities, meticulously prepared for the world’s worst pandemic. However, the question arises of how to exit the severe phase of this pandemic responsibly. The present communication discusses the follies of being under-prepared in tackling COVID-19, particularly by the economically weaker nations, and it also outlines the necessary steps that are now needed for better management of future pandemics, with international co-operation of the developed and developing countries. More attention is needed to address the paradox of digital access in excess, but of little technical use, particularly in emergencies like that of the recent viral pandemic. If the scientific analyses of the healthcare issues been carried out correctly, their predictions and strategies supported by authentic big data, managing the pandemic could have been better. Still, it is not late and expertise developed recently can help the future generations. On the individual front, mass education, awareness of hygiene, and understanding and application of basic science, particularly in rural areas is, needed to be safer rather than depend on traditional beliefs and expect miracles, a system prevalent in developing countries.","PeriodicalId":16350,"journal":{"name":"Journal of Medical Science","volume":"33 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138590919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background. Despite promising results of autologous bone marrow transplantation (BMT) in patients with lymphoma, infectious complications limit its positive outcomes. This study evaluated the incidence and associated factors of the occurrence of febrile neutropenia (FN) following BMT in patients with lymphoma. Material and methods. Overall, 147 lymphoma patients who were candidates for BMT were consecutively included. Clinical and laboratory results were recorded, and after BMT, the occurrence of FN was investigated through the daily evaluation of neutrophil count and body temperature. Results. FN occurred in 91 patients (61.9 %) on average after 12.77 ± 2.45 days after BMT. Lower fluid balance was associated with a higher risk of FN (lowest adjusted odds ratio [OR] at day -2 = 0.602, 95% confidence interval [CI] = 0.299 – 0.870, p value = 0.007). The higher uric acid level was associated with a higher risk of FN (highest adjusted OR at day -10 = 1.617, 95% CI = 1.328 – 1.963, p value = 0.035). LDH also had a positive relationship with FN (highest adjusted OR at day 0 = 1.501, 95% CI = 1.198 – 2.104, p value = 0.004). Conclusion. Adequate hydration of the patients is of paramount importance for preventing FN in patients who receive BMT. Furthermore, uric acid and LDH could be considered in future studies for risk stratification of FN.
{"title":"Lower uric acid and adequate hydration are associated with lower risk of febrile neutropenia following autologous bone marrow transplantation in patients with lymphoma","authors":"Babak Nejati, Zohreh Kourehpaz, Roya Dolatkhah, Mojtaba Varshochi, Maryam Farmani, Alireza Parviz","doi":"10.20883/medical.e836","DOIUrl":"https://doi.org/10.20883/medical.e836","url":null,"abstract":"Background. Despite promising results of autologous bone marrow transplantation (BMT) in patients with lymphoma, infectious complications limit its positive outcomes. This study evaluated the incidence and associated factors of the occurrence of febrile neutropenia (FN) following BMT in patients with lymphoma.\u0000Material and methods. Overall, 147 lymphoma patients who were candidates for BMT were consecutively included. Clinical and laboratory results were recorded, and after BMT, the occurrence of FN was investigated through the daily evaluation of neutrophil count and body temperature.\u0000Results. FN occurred in 91 patients (61.9 %) on average after 12.77 ± 2.45 days after BMT. Lower fluid balance was associated with a higher risk of FN (lowest adjusted odds ratio [OR] at day -2 = 0.602, 95% confidence interval [CI] = 0.299 – 0.870, p value = 0.007). The higher uric acid level was associated with a higher risk of FN (highest adjusted OR at day -10 = 1.617, 95% CI = 1.328 – 1.963, p value = 0.035). LDH also had a positive relationship with FN (highest adjusted OR at day 0 = 1.501, 95% CI = 1.198 – 2.104, p value = 0.004).\u0000Conclusion. Adequate hydration of the patients is of paramount importance for preventing FN in patients who receive BMT. Furthermore, uric acid and LDH could be considered in future studies for risk stratification of FN.","PeriodicalId":16350,"journal":{"name":"Journal of Medical Science","volume":"55 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138590838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aleksandra Musioł, Hanna Paluch, Anna Samoń-Drzewicka, Anna Marcinkowska-Gapińska
Mirror therapy aims to restore the function of a disabled body part by using the function of mirror neurons in the brain and mimicking the physiological activity of a healthy body part. The existence of mirror neurons was first discovered in the monkey brain, then they were proven to occur in the human brain. The working pattern is always the same. If one limb moves, the correct part of the brain is activated and the mirror neurons responsible for stimulating the other limbs are activated. This is how the "mirror" in the brain works. The therapy uses a box with a mirror on one side and hides the impaired limb in it.. When a healthy limb moves, it is reflected in the mirror. The brain receives it as a movement of an inefficient limb, even though it is only an illusion. It drives the recruitment of neural joints and provides the reconstruction of neural pathways. The activity of mirror neurons is used in rehabilitation, in mirror therapy (MT), observational action therapy (AOT) and their variants, such as therapies based on Virtual Reality (VR). A significant effect of this treatment was observed in phantom limb pain (PLP) and post-stroke syndromes, such as motor aphasia, hemiparesis of the lower or upper limb. There are reports on the use of MT in some mental diseases or in autistic people in learning emotions. This review outlines the current possibilities and hopes for therapies based on mirror neuron functions based on selected cases.
{"title":"Clinical applications and efficacy of mirror neuron function","authors":"Aleksandra Musioł, Hanna Paluch, Anna Samoń-Drzewicka, Anna Marcinkowska-Gapińska","doi":"10.20883/medical.e931","DOIUrl":"https://doi.org/10.20883/medical.e931","url":null,"abstract":"Mirror therapy aims to restore the function of a disabled body part by using the function of mirror neurons in the brain and mimicking the physiological activity of a healthy body part. The existence of mirror neurons was first discovered in the monkey brain, then they were proven to occur in the human brain. The working pattern is always the same. If one limb moves, the correct part of the brain is activated and the mirror neurons responsible for stimulating the other limbs are activated. This is how the \"mirror\" in the brain works. The therapy uses a box with a mirror on one side and hides the impaired limb in it.. When a healthy limb moves, it is reflected in the mirror. The brain receives it as a movement of an inefficient limb, even though it is only an illusion. It drives the recruitment of neural joints and provides the reconstruction of neural pathways. The activity of mirror neurons is used in rehabilitation, in mirror therapy (MT), observational action therapy (AOT) and their variants, such as therapies based on Virtual Reality (VR). A significant effect of this treatment was observed in phantom limb pain (PLP) and post-stroke syndromes, such as motor aphasia, hemiparesis of the lower or upper limb. There are reports on the use of MT in some mental diseases or in autistic people in learning emotions. This review outlines the current possibilities and hopes for therapies based on mirror neuron functions based on selected cases.","PeriodicalId":16350,"journal":{"name":"Journal of Medical Science","volume":"119 18","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138590554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Przemysław Guzik, Tomasz Krauze, Andrzej Wykrętowicz, Jarosław Piskorski
Data sharing in medical research entails making research data available to other researchers for review, re-use, and collaboration purposes. This paper seeks to describe the HYPOL (Healthy Young POLes) database, which has been prepared for sharing. This database houses the clinical characteristics and beat-to-beat cardiovascular time series of 278 individuals of Polish descent, all aged between 19 and 30 years. The data were collected from healthy volunteers who participated in multiple projects carried out at the Department of Cardiology-Intensive Therapy research laboratory, Poznan University of Medical Sciences, Poznan, Poland. The cardiovascular time series data was obtained from non-invasive continuous finger blood pressure and ECG recordings, with sessions lasting up to 45 minutes. The HYPOL database includes an xls file detailing the main clinical characteristics and text files that capture ECG-derived RR intervals, finger systolic, diastolic, and mean blood pressure values, as well as the duration of interbeat intervals. There are data from 149 women (53.6% of the total) and 129 men. The median age of all participants studied is 24 years, their BMI was <24 kg/m2, pulse rate and blood pressure were normal. The median duration of the recordings was almost 30 minutes. In addition, we summarise selected parameters of heart rate variability (HRV) and heart rate asymmetry (HRA). The HYPOL database is available at hypol.ump.edu.pl. The download of data is free of charge after simple registration. Researchers and engineers can use the database for their purposes, except for selling it. The data can be used for testing various mathematical algorithms for HRV, HRA, blood pressure variability and asymmetry, and baroflex function.
{"title":"Healthy Young POLes – HYPOL database with synchronised beat-to-beat heart rate and blood pressure signals","authors":"Przemysław Guzik, Tomasz Krauze, Andrzej Wykrętowicz, Jarosław Piskorski","doi":"10.20883/medical.e941","DOIUrl":"https://doi.org/10.20883/medical.e941","url":null,"abstract":"Data sharing in medical research entails making research data available to other researchers for review, re-use, and collaboration purposes. This paper seeks to describe the HYPOL (Healthy Young POLes) database, which has been prepared for sharing. This database houses the clinical characteristics and beat-to-beat cardiovascular time series of 278 individuals of Polish descent, all aged between 19 and 30 years. The data were collected from healthy volunteers who participated in multiple projects carried out at the Department of Cardiology-Intensive Therapy research laboratory, Poznan University of Medical Sciences, Poznan, Poland. The cardiovascular time series data was obtained from non-invasive continuous finger blood pressure and ECG recordings, with sessions lasting up to 45 minutes. The HYPOL database includes an xls file detailing the main clinical characteristics and text files that capture ECG-derived RR intervals, finger systolic, diastolic, and mean blood pressure values, as well as the duration of interbeat intervals. There are data from 149 women (53.6% of the total) and 129 men. The median age of all participants studied is 24 years, their BMI was <24 kg/m2, pulse rate and blood pressure were normal. The median duration of the recordings was almost 30 minutes. In addition, we summarise selected parameters of heart rate variability (HRV) and heart rate asymmetry (HRA). The HYPOL database is available at hypol.ump.edu.pl. The download of data is free of charge after simple registration. Researchers and engineers can use the database for their purposes, except for selling it. The data can be used for testing various mathematical algorithms for HRV, HRA, blood pressure variability and asymmetry, and baroflex function.","PeriodicalId":16350,"journal":{"name":"Journal of Medical Science","volume":"4 12","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136346359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bakteriuria asimtomatik adalah kolonisasi bakteri yang persisten pada traktus urinarius tanpa gejala simtomatik atau klinis dengan ditemukannya bakteri >105 cfu/ml. Tujuan penelitian ini adalah untuk mengkaji gambaran pola kuman dan sensitivitas antiobiotik pada ibu hamil yang berobat ke poli kebidanan dan kandungan RSUD dr. Zainoel Abidin. Rancangan penelitian ini adalah observasional deskriptif. Data diambil dari rekam medik pasien, yang sudah dilakukan pemeriksaan kultur urin. Teknik pengambilan sampel adalah accidental sampling. Hasil penelitian ini menggambarkan insiden terjadinya bakteriuria asimtomatik pada ibu hamil yang berobat ke poli kebidanan dan dan kandungan RSUD dr. Zainoel Abidin adalah 20%. Mikroba terbanyak penyebab bakteriuria asimtomatik adalah Escherichia coli (50%), dengan insiden terbanyak pada multipara (25%), dan usia >35 tahun (100%). Pada uji sensitivitas antibiotik, bakteri Escherichia coli masih sensitif terhadap beberapa jenis antibiotik diantaranya yaitu amoxicillin, ceftriaxone, dan ciprofloxacin. Resistensi terbanyak ditemukan pada bakteri Staphylococcus aureus, dibandingkan bakteri Klebsiella pneumoniae.
无症状菌尿是指尿路中持续存在细菌定植，但无症状或临床症状，发现的细菌大于 105 cfu/ml。本研究的目的是检查在扎伊努埃尔-阿比丁医生（RSUD Dr. Zainoel Abidin）妇产科诊所就诊的孕妇的细菌模式描述和抗生素敏感性。本研究采用描述性观察法。数据来源于病人的病历和尿液培养检查。抽样技术为意外抽样。研究结果表明，在扎伊努埃尔-阿比丁医生（RSUD Dr. Zainoel Abidin）妇产科诊所就诊的孕妇中，无症状菌尿的发病率为 20%。引起无症状菌尿的最常见微生物是大肠杆菌（50%），多胎妊娠（25%）和年龄大于 35 岁（100%）的孕妇发病率最高。在抗生素敏感性测试中，大肠埃希菌对阿莫西林、头孢曲松和环丙沙星等几种抗生素仍然敏感。与肺炎克雷伯菌相比，金黄色葡萄球菌的耐药性最强。
{"title":"Gambaran Pola Kuman dan Sensitivitas Antibiotik pada Ibu Hamil dengan Bakteriuria Asimtomatik yang Berobat ke RSUD dr. Zainoel Abidin","authors":"Trisia Welni, C. Yeni","doi":"10.55572/jms.v4i2.111","DOIUrl":"https://doi.org/10.55572/jms.v4i2.111","url":null,"abstract":"Bakteriuria asimtomatik adalah kolonisasi bakteri yang persisten pada traktus urinarius tanpa gejala simtomatik atau klinis dengan ditemukannya bakteri >105 cfu/ml. Tujuan penelitian ini adalah untuk mengkaji gambaran pola kuman dan sensitivitas antiobiotik pada ibu hamil yang berobat ke poli kebidanan dan kandungan RSUD dr. Zainoel Abidin. Rancangan penelitian ini adalah observasional deskriptif. Data diambil dari rekam medik pasien, yang sudah dilakukan pemeriksaan kultur urin. Teknik pengambilan sampel adalah accidental sampling. Hasil penelitian ini menggambarkan insiden terjadinya bakteriuria asimtomatik pada ibu hamil yang berobat ke poli kebidanan dan dan kandungan RSUD dr. Zainoel Abidin adalah 20%. Mikroba terbanyak penyebab bakteriuria asimtomatik adalah Escherichia coli (50%), dengan insiden terbanyak pada multipara (25%), dan usia >35 tahun (100%). Pada uji sensitivitas antibiotik, bakteri Escherichia coli masih sensitif terhadap beberapa jenis antibiotik diantaranya yaitu amoxicillin, ceftriaxone, dan ciprofloxacin. Resistensi terbanyak ditemukan pada bakteri Staphylococcus aureus, dibandingkan bakteri Klebsiella pneumoniae.","PeriodicalId":16350,"journal":{"name":"Journal of Medical Science","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139316286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Asma merupakan penyakit respiratori kronik dengan dasar inflamasi kronik yang mengakibatkan obstruksi dan hiperreaktivitas saluran respiratori sebagai hasil interaksi antara faktor genetik, faktor inang, dan lingkungan. Menurut WHO, angka kematian akibat penyakit asma di Indonesia mencapai 24.773 orang atau sekitar 1,77 persen dari total jumlah kematian penduduk, sekaligus menempatkan Indonesia di urutan ke-19 di dunia perihal kematian akibat asma. Penatalaksanaan asma harus dengan pemantauan yang berkelanjutan untuk tercapainya asma yang terkontrol, sehingga dokter harus menatalaksana pasien secara holistik dari berbagai aspek untuk meningkatkan kualitas hidup pasien. Penerapan pelayanan dokter keluarga berbasis evidence based medicine pada pasien dengan mengidentifikasi faktor risiko, masalah klinis, serta penatalaksanaan pasien berdasarkan kerangka penyelesaian masalah pasien dengan pendekatan patient centred dan family approach. Studi ini adalah studi kasus penatalaksanaan holistik anak dengan asma bronkhial. Data primer diperoleh melalui anamnesis, pemeriksaan fisik, kunjungan rumah untuk melengkapi data keluarga dan psikososial, serta lingkungan. Penilaian berdasarkan diagnosis holistik dari awal, proses dan akhir studi secara kuantitatif dan kualitatif. Pasien anak perempuan dengan asma intermiten. Faktor internal pada kasus ini antara lain faktor genetik dari ibu pasien dan kurangnya kesadaran dalam menghindari faktor pencetus. Faktor eksternal meliputi alergi dingin, debu serta kosumsi minuman dingin yang berbahan pengawet. Dilakukan intervensi farmakologis dan non farmakologis berupa edukasi dalam mencegah terjadinya serangan asma berulang pada pasien. Penegakan diagnosis dan penatalaksanaan pada pasien ini telah dilakukan secara holistik, patient centered, family approach dan berdasarkan beberapa teori dan penelitian terkini. Pada proses perubahan perilaku, pasien dan keluarga sudah mencapai tahap adoption. Asthma is a chronic respiratory disease based on chronic inflammation that results in obstruction and hyperreaction of the respiratory tract as a result of the interaction between genetic factors, host factors, and the environment.According to WHO, the death rate due to asthma in Indonesia reaches 24,773 people or around 1.77 percent of the total population mortality, while placing Indonesia in 19th in the world regarding deaths from asthma.. Asthma management must be with continuous monitoring to achieve controlled asthma, so doctors must manage patients holistically from various aspects to improve the patient's quality of life. Application of evidence-based medicine-based family doctor services to patients by identifying risk factors, clinical problems, and patient management based on a patient-centered problem solving framework with a patient-centered approach and a family approach. This study is a Case Report. Primary data were obtained through history taking, physical examination, home visits to complete family and psychosocia
{"title":"Penatalaksanaan Holistik Pasien Anak Dengan Asma Bronkial Melalui Pendekatan Kedokteran Keluarga","authors":"Syafiq Aufa, Asmaul Husna, S. Syahrizal","doi":"10.55572/jms.v4i2.115","DOIUrl":"https://doi.org/10.55572/jms.v4i2.115","url":null,"abstract":"Asma merupakan penyakit respiratori kronik dengan dasar inflamasi kronik yang mengakibatkan obstruksi dan hiperreaktivitas saluran respiratori sebagai hasil interaksi antara faktor genetik, faktor inang, dan lingkungan. Menurut WHO, angka kematian akibat penyakit asma di Indonesia mencapai 24.773 orang atau sekitar 1,77 persen dari total jumlah kematian penduduk, sekaligus menempatkan Indonesia di urutan ke-19 di dunia perihal kematian akibat asma. Penatalaksanaan asma harus dengan pemantauan yang berkelanjutan untuk tercapainya asma yang terkontrol, sehingga dokter harus menatalaksana pasien secara holistik dari berbagai aspek untuk meningkatkan kualitas hidup pasien. Penerapan pelayanan dokter keluarga berbasis evidence based medicine pada pasien dengan mengidentifikasi faktor risiko, masalah klinis, serta penatalaksanaan pasien berdasarkan kerangka penyelesaian masalah pasien dengan pendekatan patient centred dan family approach. Studi ini adalah studi kasus penatalaksanaan holistik anak dengan asma bronkhial. Data primer diperoleh melalui anamnesis, pemeriksaan fisik, kunjungan rumah untuk melengkapi data keluarga dan psikososial, serta lingkungan. Penilaian berdasarkan diagnosis holistik dari awal, proses dan akhir studi secara kuantitatif dan kualitatif. Pasien anak perempuan dengan asma intermiten. Faktor internal pada kasus ini antara lain faktor genetik dari ibu pasien dan kurangnya kesadaran dalam menghindari faktor pencetus. Faktor eksternal meliputi alergi dingin, debu serta kosumsi minuman dingin yang berbahan pengawet. Dilakukan intervensi farmakologis dan non farmakologis berupa edukasi dalam mencegah terjadinya serangan asma berulang pada pasien. Penegakan diagnosis dan penatalaksanaan pada pasien ini telah dilakukan secara holistik, patient centered, family approach dan berdasarkan beberapa teori dan penelitian terkini. Pada proses perubahan perilaku, pasien dan keluarga sudah mencapai tahap adoption. Asthma is a chronic respiratory disease based on chronic inflammation that results in obstruction and hyperreaction of the respiratory tract as a result of the interaction between genetic factors, host factors, and the environment.According to WHO, the death rate due to asthma in Indonesia reaches 24,773 people or around 1.77 percent of the total population mortality, while placing Indonesia in 19th in the world regarding deaths from asthma.. Asthma management must be with continuous monitoring to achieve controlled asthma, so doctors must manage patients holistically from various aspects to improve the patient's quality of life. Application of evidence-based medicine-based family doctor services to patients by identifying risk factors, clinical problems, and patient management based on a patient-centered problem solving framework with a patient-centered approach and a family approach. This study is a Case Report. Primary data were obtained through history taking, physical examination, home visits to complete family and psychosocia","PeriodicalId":16350,"journal":{"name":"Journal of Medical Science","volume":"41 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139316057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Miranda Rizkia, D. Darmawati, Asnawi X, Nova Fajri X
Angka kejadian hepatitis di Aceh terutama di Rumah Sakit Umum Daerah dr. Zainoel Abidin (RSUZA) Banda Aceh tergolong tinggi, sehingga tenaga kesehatan harus ekstra dalam melindungi diri dan pasien untuk mencegah terjangkitnya penyakit hepatitis terutama hepatitis misterius yang baru-baru ini terjadi. Tujuan penelian ini untuk mengetahui efektifitas edukasi kesehatan dalam peningkatan pengetahuan, sikap dan perilaku tenaga kesehatan dalam upaya pencegahan penyakit hepatitis. Metode yang digunakan adalah Randomizied Control Trial (RCT) pre-post control group design dengan pemilihan secara acak pada 86 perawat sebagai responden dari 32 ruang rawat inap. Alat pengumpulan data menggunakan kuesioner baku Eropa Monitoring Centre for Drug Addiction (EMCDDA) Harm Reduction Initiative (Knowledge Questionnaire on Viral Hepatitis for Drug Service Staff) untuk menilai pengetahuan, sedangkan untuk mengukur sikap dan perilaku menggunakan kuesioner yang disusun sendiri oleh peneliti dengan nilai reabilitas Cronbach’s Alpha 0,869 dan validitas 0,564 serat uji expert. Hasil penelitian menunjukkan dengan uji Wilcoxon menunjukkan bahwa intervensi berupa edukasi Kesehatan efektif terhadap peningkatan pengetahuan (p=0.000), sikap (p=0.000) dan perilaku (p=0.000) tenaga Kesehatan dalam pencegahan hepatitis di RSUD dr. Zainoel Abidin banda Aceh. Sehingga sangat direkomendasikan agar edukasi Kesehatan secara berkala dengan metode yang efektif dapat diberlakukan sebagai kebijakan rumah sakit untuk pencegahan penularan hepatitis umumnya bagi pasien dan keluarga dan khususnya bagi tenaga Kesehatan.
{"title":"Upaya Pencegahan Penyakit Hepatitis di Rumah Sakit Umum Daerah dr. Zainoel Abidin: Randomized Control Trial (RCT)","authors":"Miranda Rizkia, D. Darmawati, Asnawi X, Nova Fajri X","doi":"10.55572/jms.v4i2.70","DOIUrl":"https://doi.org/10.55572/jms.v4i2.70","url":null,"abstract":"Angka kejadian hepatitis di Aceh terutama di Rumah Sakit Umum Daerah dr. Zainoel Abidin (RSUZA) Banda Aceh tergolong tinggi, sehingga tenaga kesehatan harus ekstra dalam melindungi diri dan pasien untuk mencegah terjangkitnya penyakit hepatitis terutama hepatitis misterius yang baru-baru ini terjadi. Tujuan penelian ini untuk mengetahui efektifitas edukasi kesehatan dalam peningkatan pengetahuan, sikap dan perilaku tenaga kesehatan dalam upaya pencegahan penyakit hepatitis. Metode yang digunakan adalah Randomizied Control Trial (RCT) pre-post control group design dengan pemilihan secara acak pada 86 perawat sebagai responden dari 32 ruang rawat inap. Alat pengumpulan data menggunakan kuesioner baku Eropa Monitoring Centre for Drug Addiction (EMCDDA) Harm Reduction Initiative (Knowledge Questionnaire on Viral Hepatitis for Drug Service Staff) untuk menilai pengetahuan, sedangkan untuk mengukur sikap dan perilaku menggunakan kuesioner yang disusun sendiri oleh peneliti dengan nilai reabilitas Cronbach’s Alpha 0,869 dan validitas 0,564 serat uji expert. Hasil penelitian menunjukkan dengan uji Wilcoxon menunjukkan bahwa intervensi berupa edukasi Kesehatan efektif terhadap peningkatan pengetahuan (p=0.000), sikap (p=0.000) dan perilaku (p=0.000) tenaga Kesehatan dalam pencegahan hepatitis di RSUD dr. Zainoel Abidin banda Aceh. Sehingga sangat direkomendasikan agar edukasi Kesehatan secara berkala dengan metode yang efektif dapat diberlakukan sebagai kebijakan rumah sakit untuk pencegahan penularan hepatitis umumnya bagi pasien dan keluarga dan khususnya bagi tenaga Kesehatan.","PeriodicalId":16350,"journal":{"name":"Journal of Medical Science","volume":"44 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139316290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lung cancer is one of the diseases which the highest incidence and mortality in the world. Lung cancer consists of small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC) with various subtypes. Diabetes mellitus is one of the comorbidities that is often found in lung cancer patients, which is around 6% - 18% in lung cancer patients. Diabetes is a comorbidity factor that has a serious effect in increasing cancer cell progressivity through the activity of insulin growth factor (IGF) which consists of receptors (IGF-R) and binding proteins (IGFP). The role of IGF produces oncogenic mutations at the DNA level with the process of lung cancer immunity stimulates mitogenesis initiated by insulin and initiates neoplasm cells. IGF receptor mechanism has antineoplastic properties, to fulfill glycemia control that will reduce lung cancer progressivity and prevent clinical worsening so that it can help reduce lung cancer mortality with oral hypoglycemia drugs along with lung cancer therapy modalities such as cytotoxic agents, radiotherapy, immunotherapy, and surgery. The role of IGF is to amplify insulin levels in glucose, lipid, and protein metabolism. IGF can induce cell differentiation and initiation of neoplasm. Diabetes mellitus as a comorbidity can poor clinical outcomes and promote progression through IGF receptor activation in the tumorigenesis process.
{"title":"Role of Insulin Like Growth Factor (IGF) in Lung Cancer with Underlying Diabetes Melitus","authors":"Novita Andayani, M. Mauliza","doi":"10.55572/jms.v4i2.116","DOIUrl":"https://doi.org/10.55572/jms.v4i2.116","url":null,"abstract":"Lung cancer is one of the diseases which the highest incidence and mortality in the world. Lung cancer consists of small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC) with various subtypes. Diabetes mellitus is one of the comorbidities that is often found in lung cancer patients, which is around 6% - 18% in lung cancer patients. Diabetes is a comorbidity factor that has a serious effect in increasing cancer cell progressivity through the activity of insulin growth factor (IGF) which consists of receptors (IGF-R) and binding proteins (IGFP). The role of IGF produces oncogenic mutations at the DNA level with the process of lung cancer immunity stimulates mitogenesis initiated by insulin and initiates neoplasm cells. IGF receptor mechanism has antineoplastic properties, to fulfill glycemia control that will reduce lung cancer progressivity and prevent clinical worsening so that it can help reduce lung cancer mortality with oral hypoglycemia drugs along with lung cancer therapy modalities such as cytotoxic agents, radiotherapy, immunotherapy, and surgery. The role of IGF is to amplify insulin levels in glucose, lipid, and protein metabolism. IGF can induce cell differentiation and initiation of neoplasm. Diabetes mellitus as a comorbidity can poor clinical outcomes and promote progression through IGF receptor activation in the tumorigenesis process.","PeriodicalId":16350,"journal":{"name":"Journal of Medical Science","volume":"76 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139316144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Penanganan diabetes di ruang rawat inap lebih kompleks dan intensif dibanding rawat jalan. Kebanyakan pasien rawat inap menggunakan terapi insulin. Perawat ruangan adalah tenaga kesehatan garda depan yang intensif berhadapan dengan pasien sehingga sangat potensial menjadi edukator dalam maintenance terapi insulin. Penelitian ini bertujuan meningkatkan kapasitas pengetahuan dan keterampilan perawat serta mengevaluasi kepatuhan pasien diabetes menggunakan insulin setelah keluar dari rawat inap. Pengetahuan perawat dievaluasi melalui kuesioner sebelum intervensi knowledge enhancement berupa workshop insulin. Pengumpulan sampel penelitian cross sectional ini secara total sampling yaitu seluruh perawat ruang rawat inap non akut di RSUDZA selama Agustus−September 2022. Objek penelitian adalah pasien diabetes yang menggunakan insulin selama perawatan di rumah sakit. Data karakteristik responden, pengetahuan, asuhan keperawatan dan kepatuhan pasien ditampilkan secara deskriptif, untuk menilai kepatuhan pasien sebelum dan sesudah intervensi digunakan analisis independent t-test. Jumlah responden yang berpartisipasi 354 orang, 50,8% memiliki tingkat pengetahuan baik, namun hanya 29,7% berketerampilan baik dalam hal injeksi insulin. Berdasaran hasil asesmen tersebut, dilakukan workshop insulin untuk menjawab gap pengetahuan dan keterampilan. Kepatuhan pasien diukur sebelum dan sesudah workshop. Pasien dengan kepatuhan tinggi sebanyak 44,4% sebelum intervesi dan 40% sesudah intervensi, sedangkan pasien dengan tingkat kepatuhan rendah berkisar di atas 20% baik sebelum maupun sesudah intervensi. Studi ini menyimpulkan bahwa knowledge enhancement terhadap perawat ruang inap tidak berpengaruh terhadap kepatuhan pasien menggunakan insulin. Hal ini mungkin disebabkan peningkatan kapasitas perawat tentang injeksi insulin tidak menjamin terjadinya peningkatan edukasi perawat terhadap pasien, dan belum membudayanya edukasi terapi insulin yang komprehensif terhadap pasien yang dirawat inap.
{"title":"Knowledge Enhancement: Peran Edukasi Perawat Tentang Terapi Insulin Terhadap Kepatuhan Menggunakan Insulin pada Pasien Diabetes Melitus Rawat Inap","authors":"Sarah Firdausa, Hendra Zufry, Agustia Sukri Ekadamayanti, Rachmad Suhanda, Krishna Wardhana Sucipto","doi":"10.55572/jms.v4i2.76","DOIUrl":"https://doi.org/10.55572/jms.v4i2.76","url":null,"abstract":"Penanganan diabetes di ruang rawat inap lebih kompleks dan intensif dibanding rawat jalan. Kebanyakan pasien rawat inap menggunakan terapi insulin. Perawat ruangan adalah tenaga kesehatan garda depan yang intensif berhadapan dengan pasien sehingga sangat potensial menjadi edukator dalam maintenance terapi insulin. Penelitian ini bertujuan meningkatkan kapasitas pengetahuan dan keterampilan perawat serta mengevaluasi kepatuhan pasien diabetes menggunakan insulin setelah keluar dari rawat inap. Pengetahuan perawat dievaluasi melalui kuesioner sebelum intervensi knowledge enhancement berupa workshop insulin. Pengumpulan sampel penelitian cross sectional ini secara total sampling yaitu seluruh perawat ruang rawat inap non akut di RSUDZA selama Agustus−September 2022. Objek penelitian adalah pasien diabetes yang menggunakan insulin selama perawatan di rumah sakit. Data karakteristik responden, pengetahuan, asuhan keperawatan dan kepatuhan pasien ditampilkan secara deskriptif, untuk menilai kepatuhan pasien sebelum dan sesudah intervensi digunakan analisis independent t-test. Jumlah responden yang berpartisipasi 354 orang, 50,8% memiliki tingkat pengetahuan baik, namun hanya 29,7% berketerampilan baik dalam hal injeksi insulin. Berdasaran hasil asesmen tersebut, dilakukan workshop insulin untuk menjawab gap pengetahuan dan keterampilan. Kepatuhan pasien diukur sebelum dan sesudah workshop. Pasien dengan kepatuhan tinggi sebanyak 44,4% sebelum intervesi dan 40% sesudah intervensi, sedangkan pasien dengan tingkat kepatuhan rendah berkisar di atas 20% baik sebelum maupun sesudah intervensi. Studi ini menyimpulkan bahwa knowledge enhancement terhadap perawat ruang inap tidak berpengaruh terhadap kepatuhan pasien menggunakan insulin. Hal ini mungkin disebabkan peningkatan kapasitas perawat tentang injeksi insulin tidak menjamin terjadinya peningkatan edukasi perawat terhadap pasien, dan belum membudayanya edukasi terapi insulin yang komprehensif terhadap pasien yang dirawat inap.","PeriodicalId":16350,"journal":{"name":"Journal of Medical Science","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139316016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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