Journal of Nuclear Cardiology最新文献

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Refining quantitative single-photon emission computed tomography/computed tomography in transthyretin cardiac amyloidosis: Toward standardized clinical application 改进经甲状腺素型心脏淀粉样变性的定量SPECT/CT：走向标准化的临床应用。

IF 2.7 4区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Journal of Nuclear Cardiology

Pub Date : 2026-01-01 DOI: 10.1016/j.nuclcard.2025.102571

Parth Aphale PhD, Himanshu Shekhar BHMS, Shashank Dokania BHMS

引用次数: 0

Response to letter to the editor from Aphale et al. 对Aphale等人致编辑信的回应。

IF 2.7 4区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Journal of Nuclear Cardiology

Pub Date : 2026-01-01 DOI: 10.1016/j.nuclcard.2025.102572

Damien Legallois MD, PhD , Lucas Turcan MD , Denis Agostini MD, PhD , Alain Manrique MD, PhD

引用次数: 0

Reduced occupational radiation exposure after rubidium-82 PET adoption: A 10-year observational study 采用铷-82 PET后减少职业辐射暴露：一项10年观察研究。

IF 2.7 4区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Journal of Nuclear Cardiology

Pub Date : 2026-01-01 DOI: 10.1016/j.nuclcard.2025.102541

Jean-David Major MD , Richard L. Weinberg MD, PhD , Vincent Bourgeault BIng , Francois Harel MD, PhD , Claudine Regis MD , Matthieu Pelletier-Galarneau MD, MSc

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Single-photon emission computed tomography-increase ratio, a potential alternative to positron emission tomography-myocardial flow reserve, is a useful prognostic indicator in patients with known or suspected coronary heart disease at facilities without positron emission tomography 单光子发射计算机断层扫描-增加比是一种潜在的替代正电子发射断层扫描-心肌血流储备的方法，对于在没有正电子发射断层扫描的设施中已知或怀疑冠心病的患者是一种有用的预后指标

IF 2.7 4区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Journal of Nuclear Cardiology

Pub Date : 2026-01-01 DOI: 10.1016/j.nuclcard.2025.102536

Shigehiko Katoh MD, PhD, Tetsu Watanabe MD, PhD, FAHA, FESC, Takafumi Mito MD, Naoaki Hashimoto MD, Masahiro Wanezaki MD, Yoichiro Otaki MD, Harutoshi Tamura MD, Satoshi Nishiyama MD, Takanori Arimoto MD, Masafumi Watanabe MD, PhD, FESC

Background

The clinical significance of single-photon emission computed tomography (SPECT)-derived increase ratio (IR) remains unclear. This study aimed to investigate whether SPECT- IR can diagnose significant coronary artery disease (CAD), correlate with positron emission tomography (PET)-derived myocardial flow reserve (MFR), and predict the composite endpoint.

Methods

We retrospectively analyzed 60 patients with known or suspected coronary heart disease (CHD) who underwent stress-rest ^99mTc-sestamibi myocardial perfusion SPECT and ¹³N-ammonia PET. Global and regional SPECT-IR and PET-MFR were measured. The endpoint of this study was a composite of all-cause mortality and major adverse cardiovascular events.

Results

Global and regional IR predicted significant CAD, and IR correlated with their respective MFRs (global: r = .43, r² = .18, P < .001; regional: r = .34, r² = .12, P < .001). The global IR decreased with advancing CAD severity, as did global MFR. Among nonstenotic vessels, regional IR was significantly lower in patients with MFR <2.0 than in those with MFR ≥2.0. The SPECT-IR may also predict the need for early revascularization as well as PET-MFR. During a median follow-up of 765 days, nine primary events occurred. Using an IR threshold of 1.13, corresponding to an MFR of 2.0, eight of nine patients with events had IR < 1.13. The receiver operating characteristic (ROC) curve analysis of IR showed good predictive ability for adverse events.

Conclusion

SPECT-IR is associated with PET-MFR and CAD severity. The SPECT-IR may be a potential predictor of adverse outcomes in patients with known or suspected CHD.

背景单光子发射计算机断层扫描（SPECT）衍生的增加比（IR）的临床意义尚不清楚。本研究旨在探讨SPECT- IR是否能诊断冠心病（CAD），与正电子发射断层扫描（PET）衍生心肌血流储备（MFR）的相关性，并预测复合终点。方法回顾性分析60例已知或疑似冠心病（CHD）患者行压力-休息99mTc-sestamibi心肌灌注SPECT和13n -氨PET检查。测量了全球和区域的SPECT-IR和PET-MFR。这项研究的终点是全因死亡率和主要不良心血管事件的综合。结果全局和区域IR预测显著CAD，且IR与各自的MFRs相关（全局：r = 0.43, r2 = 0.18, P < 0.001；区域：r = 0.34, r2 = 0.12, P < 0.001）。总体IR随着CAD严重程度的提高而降低，总体MFR也是如此。在非狭窄血管中，MFR≥2.0的患者的区域IR明显低于MFR≥2.0的患者。SPECT-IR和PET-MFR也可以预测早期血运重建的需要。在中位765天的随访期间，发生了9个主要事件。使用1.13的IR阈值，对应于2.0的MFR， 9例事件患者中有8例的IR <； 1.13。IR的受试者工作特征（ROC）曲线分析显示对不良事件有较好的预测能力。结论spect - ir与PET-MFR及冠心病严重程度相关。SPECT-IR可能是已知或疑似冠心病患者不良结局的潜在预测因子。

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Obesity-based modulation of positron emission tomography myocardial blood flow reserve 肥胖对PET心肌血流储备的调节。

IF 2.7 4区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Journal of Nuclear Cardiology

Pub Date : 2026-01-01 DOI: 10.1016/j.nuclcard.2025.102538

Asim Shaikh MD , Maria Alwan MD , Ahmed Sayed MD , Ahmad El-Yaman MD , Mouaz H. Al-Mallah MD, MSc , Mahmoud Al Rifai MD MPH

引用次数: 0

Left ventricular function across SPECT, PET, and magnetic resonance imaging (MRI): Consistency remains elusive 左心室功能通过SPECT， PET和磁共振成像（MRI）：一致性仍然难以捉摸

IF 2.7 4区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Journal of Nuclear Cardiology

Pub Date : 2026-01-01 DOI: 10.1016/j.nuclcard.2025.102577

Waseem Hijazi MD , Piotr J. Slomka PhD

引用次数: 0

Scanner room crisis: Bridging the workforce shortage gap of nuclear medicine technologists 扫描室危机：弥合核医学技术人员的劳动力短缺差距。

IF 2.7 4区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Journal of Nuclear Cardiology

Pub Date : 2026-01-01 DOI: 10.1016/j.nuclcard.2025.102527

Mark C. Hyun CNMT, NCT, RS, RT (N, R, CT), FASNC , Ashley Brown MSHA, CNMT , Dennis A. Calnon MD, FACC, FASE, MASNC, FSCCT

引用次数: 0

“Sail while the breeze blows” Navigating the tracer-dependence of absolute flow “乘风扬帆”利用对绝对气流的示踪依赖

IF 2.7 4区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Journal of Nuclear Cardiology

Pub Date : 2026-01-01 DOI: 10.1016/j.nuclcard.2025.102576

Jonathan B. Moody PhD, Alexis Poitrasson-Rivière PhD, Jennifer M. Renaud PhD

引用次数: 0

Head-to-head comparison of left ventricular volumes and ejection fraction by [13N]ammonia positron emission tomography, myocardial perfusion single-photon emission computed tomography with cadmium-zinc-telluride technology and cardiac magnetic resonance imaging [13N]氨正电子发射断层扫描、镉锌碲化技术心肌灌注单光子发射计算机断层扫描和心脏磁共振成像对左心室容积和射血分数的头对头比较

IF 2.7 4区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Journal of Nuclear Cardiology

Pub Date : 2026-01-01 DOI: 10.1016/j.nuclcard.2025.102542

Fredrik Hedeer MD, PhD , Sofia Kvernby PhD , Jenny Oddstig PhD , Shahnaz Akil Engblom PhD

Background

Assessment of left ventricular function and dimensions is central for cardiac diagnostic imaging with cardiac positron emission tomography (PET) and myocardial perfusion single-photon emission computed tomography (MPS). The aim of this study was to compare [¹³N]NH₃ PET and MPS, head-to-head, for assessment of left ventricular ejection fraction (LVEF) and volumes using cardiac magnetic resonance (CMR) as reference.

Methods

A total of 74 patients with suspected chronic coronary syndrome, of which 27 patients were examined twice 6 months apart, were included. All performed CMR and [¹³N]NH₃ PET on the same day, and MPS with cadmium-zinc-telluride technology within 1.0 ± 1.8 days. LVEF, end-diastolic volume (EDV) and end-systolic volume (ESV) by [¹³N]NH₃ PET and MPS using standard clinical reconstruction parameters as well as reconstructions with altered filters, subsets, and iterations were compared to CMR (bias±standard deviation).

Results

Using standard clinical reconstruction parameters, both PET and MPS underestimated EDV (−58 ± 23 mL and −77 ± 22 mL, respectively) and ESV (−31 ± 19 mL and −29 ± 16 mL, respectively) compared to CMR. For LVEF, the bias was 5±6% and −3±7% for PET and MPS, respectively. The bias was slightly lowered for EDV by altering reconstruction parameters of PET (−56 ± 23 mL) and MPS (−76 ± 23 mL) images.

Conclusions

Left ventricular volumes by [¹³N]NH₃ PET and MPS are significantly underestimated compared to CMR when using standard clinical reconstruction parameters, whereas LVEF shows better agreement. Furthermore, there seems to be potential for improved accuracy of EDV, especially for [¹³N]NH₃ PET, when optimizing selected reconstruction parameters in the studied population.

背景：心脏正电子发射断层扫描（PET）和心肌灌注单光子发射计算机断层扫描（MPS）对左心室功能和尺寸的评估是心脏诊断成像的核心。本研究的目的是比较[13N]NH3 PET和MPS头对头，以心脏磁共振（CMR）为参考，评估左心室射血分数（LVEF）和容积。方法：74例疑似慢性冠状动脉综合征患者，其中27例间隔6个月复查2次。当日行CMR和[13N]NH3 PET，在1.0±1.8天内行镉锌碲化技术MPS。将[13N]NH3 PET和MPS的LVEF、舒张末期容积（EDV）和收缩末期容积（ESV）与CMR进行比较（偏差±SD），使用标准临床重建参数以及改变过滤器、子集和迭代重建。结果：使用标准临床重建参数，与CMR相比，PET和MPS均低估了EDV（分别为-58±23 ml和-77±22 ml）和ESV（分别为-31±19 ml和-29±16 ml）。对于LVEF， PET和MPS的偏差分别为5±6%和-3±7%。通过改变PET（-56±23 ml）和MPS（-76±23 ml）图像的重建参数，EDV的偏差略有降低。结论：与CMR相比，使用标准临床重建参数时，[13N]NH3 PET和MPS的左室容积明显被低估，而LVEF的一致性更好。此外，在优化研究人群中选择的重建参数时，似乎有可能提高EDV的准确性，特别是对于[13N]NH3 PET。

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Flow is the signal 流是信号

IF 2.7 4区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Journal of Nuclear Cardiology

Pub Date : 2026-01-01 DOI: 10.1016/j.nuclcard.2026.102624

Marcelo F. Di Carli MD, MASNC

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