Pub Date : 2017-08-01DOI: 10.12677/JOCR.2017.53019
曹忠民
从历史发展和化学原理对IUPAC取代命名进行了研究，发现其中不合理的论述和命名过程是由于错误地将特性基团看作官能团，并且代替了官能团。正确地将特性基团作为形成官能团的取代基，同时将这两种基团合理地用于取代命名，结果形成以取代后缀为标志的现代取代命名。它较无特性基团参与的取代命名更为系统化，更便于对不同结构化合物的命名，并且与CA取代命名一致。 IUPAC substitutive nomenclature is studied from its historical development and chemical theory. It is found that mistaking and using characteristic group as functional group result in forming ir-rational naming rules and procedures. By taking characteristic group as a substituent producing functional group after substitution and correctly using these two groups in the nomenclature, modern substitutive nomenclature, characterized by the substitutive suffix, is formed. Modern substitutive nomenclature is more systematic and more versatile in naming organic compounds of various structures than the previous substitutive nomenclature without characteristic group in-volved. It is also in agreement with the “naming selection principle” of CA.
从历史发展和化学原理对IUPAC取代命名进行了研究，发现其中不合理的论述和命名过程是由于错误地将特性基团看作官能团，并且代替了官能团。正确地将特性基团作为形成官能团的取代基，同时将这两种基团合理地用于取代命名，结果形成以取代后缀为标志的现代取代命名。它较无特性基团参与的取代命名更为系统化，更便于对不同结构化合物的命名，并且与CA取代命名一致。 IUPAC substitutive nomenclature is studied from its historical development and chemical theory. It is found that mistaking and using characteristic group as functional group result in forming ir-rational naming rules and procedures. By taking characteristic group as a substituent producing functional group after substitution and correctly using these two groups in the nomenclature, modern substitutive nomenclature, characterized by the substitutive suffix, is formed. Modern substitutive nomenclature is more systematic and more versatile in naming organic compounds of various structures than the previous substitutive nomenclature without characteristic group in-volved. It is also in agreement with the “naming selection principle” of CA.
{"title":"国际有机化学命名法研究(二)现代取代命名法 Studies on the International Nomenclature of Organic Chemistry: (II) Modern Substitutive Nomenclature","authors":"曹忠民","doi":"10.12677/JOCR.2017.53019","DOIUrl":"https://doi.org/10.12677/JOCR.2017.53019","url":null,"abstract":"从历史发展和化学原理对IUPAC取代命名进行了研究，发现其中不合理的论述和命名过程是由于错误地将特性基团看作官能团，并且代替了官能团。正确地将特性基团作为形成官能团的取代基，同时将这两种基团合理地用于取代命名，结果形成以取代后缀为标志的现代取代命名。它较无特性基团参与的取代命名更为系统化，更便于对不同结构化合物的命名，并且与CA取代命名一致。 IUPAC substitutive nomenclature is studied from its historical development and chemical theory. It is found that mistaking and using characteristic group as functional group result in forming ir-rational naming rules and procedures. By taking characteristic group as a substituent producing functional group after substitution and correctly using these two groups in the nomenclature, modern substitutive nomenclature, characterized by the substitutive suffix, is formed. Modern substitutive nomenclature is more systematic and more versatile in naming organic compounds of various structures than the previous substitutive nomenclature without characteristic group in-volved. It is also in agreement with the “naming selection principle” of CA.","PeriodicalId":16596,"journal":{"name":"Journal of Organic Chemistry Research","volume":"46 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77631588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-05-17DOI: 10.12677/JOCR.2017.52017
杜婷, 张奎, 赵松, 张旭龙, 黄艳
分别以1,6-己二胺和对苯二胺为原料，与对映体纯L-缬氨酸发生缩合进而得到手性氨基酚化合物。所合成氨基酚及相应的中间产物经过高分辨质谱、核磁共振氢谱和核磁共振碳谱等进行表征并确认结构。此外，化合物2A和7B-1通过X-ray单晶衍射法确定了结构。 In this paper, 1,6-hexamethylenediamine and p-phenylenediamine were selected to react respec-tively with commercially available L-valine to obtain the desired symmetrical aminophenol com-pounds. The structures of the aminophenol and the corresponding intermediate were characterized by high resolution mass spectrometry, nuclear magnetic resonance spectroscopy. In addition, a single crystal of compound 2A and 7B-1were obtained by recrystallization, and their structures were determined by x-ray analysis.
分别以1,6-己二胺和对苯二胺为原料，与对映体纯L-缬氨酸发生缩合进而得到手性氨基酚化合物。所合成氨基酚及相应的中间产物经过高分辨质谱、核磁共振氢谱和核磁共振碳谱等进行表征并确认结构。此外，化合物2A和7B-1通过X-ray单晶衍射法确定了结构。 In this paper, 1,6-hexamethylenediamine and p-phenylenediamine were selected to react respec-tively with commercially available L-valine to obtain the desired symmetrical aminophenol com-pounds. The structures of the aminophenol and the corresponding intermediate were characterized by high resolution mass spectrometry, nuclear magnetic resonance spectroscopy. In addition, a single crystal of compound 2A and 7B-1were obtained by recrystallization, and their structures were determined by x-ray analysis.
{"title":"具有对称结构手性氨基酚化合物的合成 Synthesis of Symmetric Chiral Aminophenol Compounds","authors":"杜婷, 张奎, 赵松, 张旭龙, 黄艳","doi":"10.12677/JOCR.2017.52017","DOIUrl":"https://doi.org/10.12677/JOCR.2017.52017","url":null,"abstract":"分别以1,6-己二胺和对苯二胺为原料，与对映体纯L-缬氨酸发生缩合进而得到手性氨基酚化合物。所合成氨基酚及相应的中间产物经过高分辨质谱、核磁共振氢谱和核磁共振碳谱等进行表征并确认结构。此外，化合物2A和7B-1通过X-ray单晶衍射法确定了结构。 In this paper, 1,6-hexamethylenediamine and p-phenylenediamine were selected to react respec-tively with commercially available L-valine to obtain the desired symmetrical aminophenol com-pounds. The structures of the aminophenol and the corresponding intermediate were characterized by high resolution mass spectrometry, nuclear magnetic resonance spectroscopy. In addition, a single crystal of compound 2A and 7B-1were obtained by recrystallization, and their structures were determined by x-ray analysis.","PeriodicalId":16596,"journal":{"name":"Journal of Organic Chemistry Research","volume":"207 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82825933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-05-17DOI: 10.12677/JOCR.2017.52015
薛刚, 马成红, 陈玉娟
苯乙醇苷化合物具有较强的生物活性且具有显著的药理活性特性。广泛的存在于植物中，主要分布于玄参科、蔷薇科、列当科、车前科、马鞭草科等高等植物中。这类化合物的药用价值较高，来源较广泛，因此研究比较多。本文对国内外有关苯乙醇苷类化合物的研究作一综述，主要综合研究苯乙醇苷类化合物的植物主要来源、提取、分离及合成方法、化学结构、理化性质，同时对苯乙醇苷类化合物的药理作用机制做了较详细介绍，对苯乙醇苷的进一步研究提供理论基础。 Phenylethanol glycoside compounds have a strong biological activity and significant pharmaco-logical activity characteristics. They are widely distributed in plants, mainly distributed in Scrophulariaceae, Rosaceae, Orobanchaceae, Plantaginaceae, Verbenaceae and so on. These com-pounds have significant activity, which are Potential drugs. There are many researches about their activity and medical structures. In this paper, the recent studies on phenylethanol glycoside com-pounds are reviewed. The main sources, extraction, separation and synthesis methods, chemical structures, physical and chemical properties of phenylethanoid glycosides are studied in this paper. Pharmacological mechanism of the mechanism are descript in detail. It is useful to study phenylethanol glycosides in the further.
苯乙醇苷化合物具有较强的生物活性且具有显著的药理活性特性。广泛的存在于植物中，主要分布于玄参科、蔷薇科、列当科、车前科、马鞭草科等高等植物中。这类化合物的药用价值较高，来源较广泛，因此研究比较多。本文对国内外有关苯乙醇苷类化合物的研究作一综述，主要综合研究苯乙醇苷类化合物的植物主要来源、提取、分离及合成方法、化学结构、理化性质，同时对苯乙醇苷类化合物的药理作用机制做了较详细介绍，对苯乙醇苷的进一步研究提供理论基础。 Phenylethanol glycoside compounds have a strong biological activity and significant pharmaco-logical activity characteristics. They are widely distributed in plants, mainly distributed in Scrophulariaceae, Rosaceae, Orobanchaceae, Plantaginaceae, Verbenaceae and so on. These com-pounds have significant activity, which are Potential drugs. There are many researches about their activity and medical structures. In this paper, the recent studies on phenylethanol glycoside com-pounds are reviewed. The main sources, extraction, separation and synthesis methods, chemical structures, physical and chemical properties of phenylethanoid glycosides are studied in this paper. Pharmacological mechanism of the mechanism are descript in detail. It is useful to study phenylethanol glycosides in the further.
{"title":"苯乙醇苷类化合物的研究进展 Progress of Phenylethanol Glycosides in Plants","authors":"薛刚, 马成红, 陈玉娟","doi":"10.12677/JOCR.2017.52015","DOIUrl":"https://doi.org/10.12677/JOCR.2017.52015","url":null,"abstract":"苯乙醇苷化合物具有较强的生物活性且具有显著的药理活性特性。广泛的存在于植物中，主要分布于玄参科、蔷薇科、列当科、车前科、马鞭草科等高等植物中。这类化合物的药用价值较高，来源较广泛，因此研究比较多。本文对国内外有关苯乙醇苷类化合物的研究作一综述，主要综合研究苯乙醇苷类化合物的植物主要来源、提取、分离及合成方法、化学结构、理化性质，同时对苯乙醇苷类化合物的药理作用机制做了较详细介绍，对苯乙醇苷的进一步研究提供理论基础。 Phenylethanol glycoside compounds have a strong biological activity and significant pharmaco-logical activity characteristics. They are widely distributed in plants, mainly distributed in Scrophulariaceae, Rosaceae, Orobanchaceae, Plantaginaceae, Verbenaceae and so on. These com-pounds have significant activity, which are Potential drugs. There are many researches about their activity and medical structures. In this paper, the recent studies on phenylethanol glycoside com-pounds are reviewed. The main sources, extraction, separation and synthesis methods, chemical structures, physical and chemical properties of phenylethanoid glycosides are studied in this paper. Pharmacological mechanism of the mechanism are descript in detail. It is useful to study phenylethanol glycosides in the further.","PeriodicalId":16596,"journal":{"name":"Journal of Organic Chemistry Research","volume":"60 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89451179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-05-17DOI: 10.12677/JOCR.2017.52009
张增鹏, 刘晨江
本文报道了一种离子液体1-丁基-3-羧甲基苯并三唑三氟乙酸盐催化β-萘酚、芳香醛和胺在无溶剂条件下发生三组分缩合反应绿色、高效合成氨基萘酚化合物的方法。离子液体催化剂至少可以循环使用5次，并且活性没有明显降低。 A green and highly efficient approach for the synthesis of aminonaphthols via ionic liquid 1-butyl-3-carboxymethyl benzotriazole trifluoroacetate catalyzed three component condensation recation of β-naphthols, aromatic aldehydes and amines under solvent-free conditions has been reported. The catalyst ionic liquid can be easily recycled and reused for at least five cycles without obvious loss of catalytic activity.
本文报道了一种离子液体1-丁基-3-羧甲基苯并三唑三氟乙酸盐催化β-萘酚、芳香醛和胺在无溶剂条件下发生三组分缩合反应绿色、高效合成氨基萘酚化合物的方法。离子液体催化剂至少可以循环使用5次，并且活性没有明显降低。 A green and highly efficient approach for the synthesis of aminonaphthols via ionic liquid 1-butyl-3-carboxymethyl benzotriazole trifluoroacetate catalyzed three component condensation recation of β-naphthols, aromatic aldehydes and amines under solvent-free conditions has been reported. The catalyst ionic liquid can be easily recycled and reused for at least five cycles without obvious loss of catalytic activity.
{"title":"离子液体1-丁基-3-羧甲基苯并三唑三氟乙酸盐催化三组分缩合反应合成氨基萘酚化合物","authors":"张增鹏, 刘晨江","doi":"10.12677/JOCR.2017.52009","DOIUrl":"https://doi.org/10.12677/JOCR.2017.52009","url":null,"abstract":"本文报道了一种离子液体1-丁基-3-羧甲基苯并三唑三氟乙酸盐催化β-萘酚、芳香醛和胺在无溶剂条件下发生三组分缩合反应绿色、高效合成氨基萘酚化合物的方法。离子液体催化剂至少可以循环使用5次，并且活性没有明显降低。 A green and highly efficient approach for the synthesis of aminonaphthols via ionic liquid 1-butyl-3-carboxymethyl benzotriazole trifluoroacetate catalyzed three component condensation recation of β-naphthols, aromatic aldehydes and amines under solvent-free conditions has been reported. The catalyst ionic liquid can be easily recycled and reused for at least five cycles without obvious loss of catalytic activity.","PeriodicalId":16596,"journal":{"name":"Journal of Organic Chemistry Research","volume":"37 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84149706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-05-17DOI: 10.12677/JOCR.2017.52016
阿依古里•买土送, 阿布力克木·克热木, 卡玛勒别克•吾买尔, 鲁提夫拉•吾守尔
采用拓扑共振能(Topological Resonance Energy, TRE)方法对氮原子插入在C30(D5h)异构体后形成的异质富勒烯的芳香性进行了研究，分析了氮原子的取代位置和稳定性之间的关系，解释了各种异构体的相对稳定性。最后，用最小键共振能(Minimum Bond Resonance Energy, Min BRE)方法对C30(D5h)和C26N4的动力学稳定性进行了研究。研究结果表明，C30(D5h)在中性状态下，因TRE为负值具有反芳香性，C24N4所有异构体TRE为正值具有芳香性。Min BRE方法研究结果证明了C30(D5h)和C26N4的动力学不稳定性与分子中具有较高反芳香性键直接有关。TRE和min BRE方法研究结果表明，C26N4各异构体在二价阴离子状态下不仅具有较高的芳香性而且也具有较高的动力学稳定性。 The aromaticity of heterofullerene C26N4 formed on the initial C30 cage of D5h symmetry have been systematically investigated by the topological resonance energy (TRE). The relationships between the stabilities of the C26N4 isomers and the sites where nitrogen atoms dope at the C30 cage have been discussed. The kinetic stability of C30(D5h), C26N4 isomers were examined by the minimum bond resonance energy (min BRE) model. The min BRE model results show that kinetic instability of these compounds are closely related to the existence of highly reactive substructures in the molecule. Both the TRE and min BRE results show that the C24N2-4 isomers were found to not only have aromaticity but also have large kinetic stability.
采用拓扑共振能(Topological Resonance Energy, TRE)方法对氮原子插入在C30(D5h)异构体后形成的异质富勒烯的芳香性进行了研究，分析了氮原子的取代位置和稳定性之间的关系，解释了各种异构体的相对稳定性。最后，用最小键共振能(Minimum Bond Resonance Energy, Min BRE)方法对C30(D5h)和C26N4的动力学稳定性进行了研究。研究结果表明，C30(D5h)在中性状态下，因TRE为负值具有反芳香性，C24N4所有异构体TRE为正值具有芳香性。Min BRE方法研究结果证明了C30(D5h)和C26N4的动力学不稳定性与分子中具有较高反芳香性键直接有关。TRE和min BRE方法研究结果表明，C26N4各异构体在二价阴离子状态下不仅具有较高的芳香性而且也具有较高的动力学稳定性。 The aromaticity of heterofullerene C26N4 formed on the initial C30 cage of D5h symmetry have been systematically investigated by the topological resonance energy (TRE). The relationships between the stabilities of the C26N4 isomers and the sites where nitrogen atoms dope at the C30 cage have been discussed. The kinetic stability of C30(D5h), C26N4 isomers were examined by the minimum bond resonance energy (min BRE) model. The min BRE model results show that kinetic instability of these compounds are closely related to the existence of highly reactive substructures in the molecule. Both the TRE and min BRE results show that the C24N2-4 isomers were found to not only have aromaticity but also have large kinetic stability.
{"title":"异质富勒烯C26N4的芳香性和动力学稳定性研究 The Study on the Aromaticity and Kinetic Stability of Heterofullerene C26N4","authors":"阿依古里•买土送, 阿布力克木·克热木, 卡玛勒别克•吾买尔, 鲁提夫拉•吾守尔","doi":"10.12677/JOCR.2017.52016","DOIUrl":"https://doi.org/10.12677/JOCR.2017.52016","url":null,"abstract":"采用拓扑共振能(Topological Resonance Energy, TRE)方法对氮原子插入在C30(D5h)异构体后形成的异质富勒烯的芳香性进行了研究，分析了氮原子的取代位置和稳定性之间的关系，解释了各种异构体的相对稳定性。最后，用最小键共振能(Minimum Bond Resonance Energy, Min BRE)方法对C30(D5h)和C26N4的动力学稳定性进行了研究。研究结果表明，C30(D5h)在中性状态下，因TRE为负值具有反芳香性，C24N4所有异构体TRE为正值具有芳香性。Min BRE方法研究结果证明了C30(D5h)和C26N4的动力学不稳定性与分子中具有较高反芳香性键直接有关。TRE和min BRE方法研究结果表明，C26N4各异构体在二价阴离子状态下不仅具有较高的芳香性而且也具有较高的动力学稳定性。 The aromaticity of heterofullerene C26N4 formed on the initial C30 cage of D5h symmetry have been systematically investigated by the topological resonance energy (TRE). The relationships between the stabilities of the C26N4 isomers and the sites where nitrogen atoms dope at the C30 cage have been discussed. The kinetic stability of C30(D5h), C26N4 isomers were examined by the minimum bond resonance energy (min BRE) model. The min BRE model results show that kinetic instability of these compounds are closely related to the existence of highly reactive substructures in the molecule. Both the TRE and min BRE results show that the C24N2-4 isomers were found to not only have aromaticity but also have large kinetic stability.","PeriodicalId":16596,"journal":{"name":"Journal of Organic Chemistry Research","volume":"24 1","pages":"120-127"},"PeriodicalIF":0.0,"publicationDate":"2017-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79752601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-05-17DOI: 10.12677/JOCR.2017.52012
邹琼宇, 吴海峰, 黄俊, 张莉, 陈迪钊, 李欣, 贺贵妃, 梁芬芳
目的：研究赭曲霉次生代谢产物。方法：利用多种色谱层析方法分离出次生代谢产物，通过ESI-MS/MS及NMR等波谱方法鉴定结构。结果：共分离鉴定出9种化合物，依次是赭曲霉毒素A(1)、赭曲霉毒素B(2)、neohydroxyaspergillic acid(3)、(3R)-5-hydroxymellein(4)、5,6-dihydropenicillic acid(5)、mesaconic acid(6)、p-hydroxybenzoic acid(7)、circumdatin G(8)、(22E,24R)-ergosta-7,22-diene-3β,5α,6β- triol(9)。结论：化合物3~9为首次从赭曲霉中分离得到的化合物。 Objective: To study the secondary metabolites from Aspergillus ochraceus. Methods: The constit-uents were isolated and purified by column chromatography and preparative TLC. Their structures were identified on the basis of comprehensive spectroscopic methods including ESI-MS and spectral data (1H, 13C-NMR). Results: Nine compounds were isolated and identified as ochratoxin A (1), ochratoxin B (2), neohydroxyaspergillic acid (3), (3R)-5-hydroxymellein (4), 5,6-dihydro- penicillic acid (5), mesaconic acid (6), p-hydroxybenzoic acid (7), circumdatin G (8), (22E,24R)- ergosta-7,22-diene-3β,5α,6β-triol (9). Conclusion: The compounds 3~9 were isolated from Asper-gillus ochraceus for the first time.
目的：研究赭曲霉次生代谢产物。方法：利用多种色谱层析方法分离出次生代谢产物，通过ESI-MS/MS及NMR等波谱方法鉴定结构。结果：共分离鉴定出9种化合物，依次是赭曲霉毒素A(1)、赭曲霉毒素B(2)、neohydroxyaspergillic acid(3)、(3R)-5-hydroxymellein(4)、5,6-dihydropenicillic acid(5)、mesaconic acid(6)、p-hydroxybenzoic acid(7)、circumdatin G(8)、(22E,24R)-ergosta-7,22-diene-3β,5α,6β- triol(9)。结论：化合物3~9为首次从赭曲霉中分离得到的化合物。 Objective: To study the secondary metabolites from Aspergillus ochraceus. Methods: The constit-uents were isolated and purified by column chromatography and preparative TLC. Their structures were identified on the basis of comprehensive spectroscopic methods including ESI-MS and spectral data (1H, 13C-NMR). Results: Nine compounds were isolated and identified as ochratoxin A (1), ochratoxin B (2), neohydroxyaspergillic acid (3), (3R)-5-hydroxymellein (4), 5,6-dihydro- penicillic acid (5), mesaconic acid (6), p-hydroxybenzoic acid (7), circumdatin G (8), (22E,24R)- ergosta-7,22-diene-3β,5α,6β-triol (9). Conclusion: The compounds 3~9 were isolated from Asper-gillus ochraceus for the first time.
{"title":"赭曲霉次生代谢产物研究 Study on the Secondary Metabolites of Aspergillus ochraceus","authors":"邹琼宇, 吴海峰, 黄俊, 张莉, 陈迪钊, 李欣, 贺贵妃, 梁芬芳","doi":"10.12677/JOCR.2017.52012","DOIUrl":"https://doi.org/10.12677/JOCR.2017.52012","url":null,"abstract":"目的：研究赭曲霉次生代谢产物。方法：利用多种色谱层析方法分离出次生代谢产物，通过ESI-MS/MS及NMR等波谱方法鉴定结构。结果：共分离鉴定出9种化合物，依次是赭曲霉毒素A(1)、赭曲霉毒素B(2)、neohydroxyaspergillic acid(3)、(3R)-5-hydroxymellein(4)、5,6-dihydropenicillic acid(5)、mesaconic acid(6)、p-hydroxybenzoic acid(7)、circumdatin G(8)、(22E,24R)-ergosta-7,22-diene-3β,5α,6β- triol(9)。结论：化合物3~9为首次从赭曲霉中分离得到的化合物。 Objective: To study the secondary metabolites from Aspergillus ochraceus. Methods: The constit-uents were isolated and purified by column chromatography and preparative TLC. Their structures were identified on the basis of comprehensive spectroscopic methods including ESI-MS and spectral data (1H, 13C-NMR). Results: Nine compounds were isolated and identified as ochratoxin A (1), ochratoxin B (2), neohydroxyaspergillic acid (3), (3R)-5-hydroxymellein (4), 5,6-dihydro- penicillic acid (5), mesaconic acid (6), p-hydroxybenzoic acid (7), circumdatin G (8), (22E,24R)- ergosta-7,22-diene-3β,5α,6β-triol (9). Conclusion: The compounds 3~9 were isolated from Asper-gillus ochraceus for the first time.","PeriodicalId":16596,"journal":{"name":"Journal of Organic Chemistry Research","volume":"10 1","pages":"94-99"},"PeriodicalIF":0.0,"publicationDate":"2017-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91123300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-05-17DOI: 10.12677/JOCR.2017.52013
张连生, 万玮, 王萃娟, 熊霄阳, 赵鑫, 李泽贤, 陈志斌
基于配体2,2’-二硫二吡啶(简称Dpds)，采用分层扩散法，合成出六核簇状配位化合物Cu6(C5H4NS)6。采用密度泛函理论(DFT)下的B3LYP计算方法、NBO计算方法对该配合物进行量子化学计算，同时进行了前线轨道的研究。结果表明：每个配合物含六个铜离子、六个2-巯基吡啶阴离子，优化后的理论值与实验值比较吻合，误差在允许的范围内，理论计算的完成证明了实验数据的可靠性。 A six-core cluster compound Cu6(C5H4NS)6, was prepared by layered a N, N-Dimethylformamide solution of Cu(CH3COO)2•H2O on a dichloromethane solution of Dpds. The quantum chemistry cal-culation of the complex was carried out by using the B3LYP calculation method of density functional theory (DFT) and the NBO calculation method; at the same time, the research of frontier orbital is carried out. The results showed that the six-core copper (II) cluster complex contains six crystallographically unique Cu (II) ions and six 2-mercapto pyridine anions. It is found that the theoretical values are in agreement with the experimental ones, and the error is within the al-lowable range. And the completion of theoretical calculations proved the reliability of the experi-mental data.
基于配体2,2’-二硫二吡啶(简称Dpds)，采用分层扩散法，合成出六核簇状配位化合物Cu6(C5H4NS)6。采用密度泛函理论(DFT)下的B3LYP计算方法、NBO计算方法对该配合物进行量子化学计算，同时进行了前线轨道的研究。结果表明：每个配合物含六个铜离子、六个2-巯基吡啶阴离子，优化后的理论值与实验值比较吻合，误差在允许的范围内，理论计算的完成证明了实验数据的可靠性。 A six-core cluster compound Cu6(C5H4NS)6, was prepared by layered a N, N-Dimethylformamide solution of Cu(CH3COO)2•H2O on a dichloromethane solution of Dpds. The quantum chemistry cal-culation of the complex was carried out by using the B3LYP calculation method of density functional theory (DFT) and the NBO calculation method; at the same time, the research of frontier orbital is carried out. The results showed that the six-core copper (II) cluster complex contains six crystallographically unique Cu (II) ions and six 2-mercapto pyridine anions. It is found that the theoretical values are in agreement with the experimental ones, and the error is within the al-lowable range. And the completion of theoretical calculations proved the reliability of the experi-mental data.
{"title":"2-巯基吡啶配合物的合成及量子化学计算 The Synthesis and Quantum Chemistry Calculation Based on 2-Thiol Pyridine Ligand","authors":"张连生, 万玮, 王萃娟, 熊霄阳, 赵鑫, 李泽贤, 陈志斌","doi":"10.12677/JOCR.2017.52013","DOIUrl":"https://doi.org/10.12677/JOCR.2017.52013","url":null,"abstract":"基于配体2,2’-二硫二吡啶(简称Dpds)，采用分层扩散法，合成出六核簇状配位化合物Cu6(C5H4NS)6。采用密度泛函理论(DFT)下的B3LYP计算方法、NBO计算方法对该配合物进行量子化学计算，同时进行了前线轨道的研究。结果表明：每个配合物含六个铜离子、六个2-巯基吡啶阴离子，优化后的理论值与实验值比较吻合，误差在允许的范围内，理论计算的完成证明了实验数据的可靠性。 A six-core cluster compound Cu6(C5H4NS)6, was prepared by layered a N, N-Dimethylformamide solution of Cu(CH3COO)2•H2O on a dichloromethane solution of Dpds. The quantum chemistry cal-culation of the complex was carried out by using the B3LYP calculation method of density functional theory (DFT) and the NBO calculation method; at the same time, the research of frontier orbital is carried out. The results showed that the six-core copper (II) cluster complex contains six crystallographically unique Cu (II) ions and six 2-mercapto pyridine anions. It is found that the theoretical values are in agreement with the experimental ones, and the error is within the al-lowable range. And the completion of theoretical calculations proved the reliability of the experi-mental data.","PeriodicalId":16596,"journal":{"name":"Journal of Organic Chemistry Research","volume":"31 1","pages":"100-103"},"PeriodicalIF":0.0,"publicationDate":"2017-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90803035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-05-17DOI: 10.12677/JOCR.2017.52014
杨敬辉, 邢刘庄, 谢绍雷, 邢雪建, 侯亚东, 吴阳, 惠永海
以介孔分子筛MCM-41固载磷钨酸为催化剂，对苯并三氮唑与查尔酮进行了氮杂迈克加成的催化研究。经过条件筛选，发现MCM-41中的磷钨酸负载量对该反应体系有很大的影响，其中50 wt%的磷钨酸负载量更有利于反应的进行，产率可达98%。通过NMR对产物结构进行了表征，并且催化剂具有一定的回收再利用效果。 In this paper, mesoporous siliceous material MCM-41 supported H3PW12O40 (PW) could act as an efficient catalyst for the aza-Michael addition reaction of chalcone with benzotriazole. As can be seen from a serial of reaction conditions, the ratio of PW and MCM-41 plays a critical role in the reaction, and the best catalyzed result was achieved when using 50 wt% PW/MCM-41, and the yield was up to 98%. All the products were confirmed by NMR techniques. Moreover, the catalyst was also found to exhibit better recyclability.
以介孔分子筛MCM-41固载磷钨酸为催化剂，对苯并三氮唑与查尔酮进行了氮杂迈克加成的催化研究。经过条件筛选，发现MCM-41中的磷钨酸负载量对该反应体系有很大的影响，其中50 wt%的磷钨酸负载量更有利于反应的进行，产率可达98%。通过NMR对产物结构进行了表征，并且催化剂具有一定的回收再利用效果。 In this paper, mesoporous siliceous material MCM-41 supported H3PW12O40 (PW) could act as an efficient catalyst for the aza-Michael addition reaction of chalcone with benzotriazole. As can be seen from a serial of reaction conditions, the ratio of PW and MCM-41 plays a critical role in the reaction, and the best catalyzed result was achieved when using 50 wt% PW/MCM-41, and the yield was up to 98%. All the products were confirmed by NMR techniques. Moreover, the catalyst was also found to exhibit better recyclability.
{"title":"介孔分子筛MCM-41固载磷钨酸催化苯并三氮唑与查尔酮的氮杂迈克加成反应研究 Aza-Michael Addition of Chalcone with Benzotriazole Catalyzed by MCM-41 Immobilized H3PW12O40","authors":"杨敬辉, 邢刘庄, 谢绍雷, 邢雪建, 侯亚东, 吴阳, 惠永海","doi":"10.12677/JOCR.2017.52014","DOIUrl":"https://doi.org/10.12677/JOCR.2017.52014","url":null,"abstract":"以介孔分子筛MCM-41固载磷钨酸为催化剂，对苯并三氮唑与查尔酮进行了氮杂迈克加成的催化研究。经过条件筛选，发现MCM-41中的磷钨酸负载量对该反应体系有很大的影响，其中50 wt%的磷钨酸负载量更有利于反应的进行，产率可达98%。通过NMR对产物结构进行了表征，并且催化剂具有一定的回收再利用效果。 In this paper, mesoporous siliceous material MCM-41 supported H3PW12O40 (PW) could act as an efficient catalyst for the aza-Michael addition reaction of chalcone with benzotriazole. As can be seen from a serial of reaction conditions, the ratio of PW and MCM-41 plays a critical role in the reaction, and the best catalyzed result was achieved when using 50 wt% PW/MCM-41, and the yield was up to 98%. All the products were confirmed by NMR techniques. Moreover, the catalyst was also found to exhibit better recyclability.","PeriodicalId":16596,"journal":{"name":"Journal of Organic Chemistry Research","volume":"32 1","pages":"107-113"},"PeriodicalIF":0.0,"publicationDate":"2017-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86809168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-05-17DOI: 10.12677/JOCR.2017.52010
张增鹏, 刘晨江
无溶剂条件下，阳离子为苯并三唑、阴离子为三氟乙酸根的羧基功能化离子液体作为环境友好的催化剂，高效地合成了一系列3,4-二氢嘧啶-2(1H)-酮或硫酮。此外，离子液体[C2O2BBTA][TFA]循环使用至少4次，且催化活性没有明显降低。 Carboxyl functional ionic liquid with benzotriazole cation and trifluoroacetate anion can be used as environmental-friendly catalyst for the efficient synthesis of 3,4-dihydropyrimidin-2(1H) ones /thiones under solvent-free conditions. Moreover, the ionic liquid [C2O2BBTA][TFA] can be easily recycled and reused for at least four cycles without obvious loss of catalytic activity.
无溶剂条件下，阳离子为苯并三唑、阴离子为三氟乙酸根的羧基功能化离子液体作为环境友好的催化剂，高效地合成了一系列3,4-二氢嘧啶-2(1H)-酮或硫酮。此外，离子液体[C2O2BBTA][TFA]循环使用至少4次，且催化活性没有明显降低。 Carboxyl functional ionic liquid with benzotriazole cation and trifluoroacetate anion can be used as environmental-friendly catalyst for the efficient synthesis of 3,4-dihydropyrimidin-2(1H) ones /thiones under solvent-free conditions. Moreover, the ionic liquid [C2O2BBTA][TFA] can be easily recycled and reused for at least four cycles without obvious loss of catalytic activity.
{"title":"离子液体[C2O2BBTA][TFA]催化合成3,4-二氢嘧啶-2-(1H)-酮/硫酮","authors":"张增鹏, 刘晨江","doi":"10.12677/JOCR.2017.52010","DOIUrl":"https://doi.org/10.12677/JOCR.2017.52010","url":null,"abstract":"无溶剂条件下，阳离子为苯并三唑、阴离子为三氟乙酸根的羧基功能化离子液体作为环境友好的催化剂，高效地合成了一系列3,4-二氢嘧啶-2(1H)-酮或硫酮。此外，离子液体[C2O2BBTA][TFA]循环使用至少4次，且催化活性没有明显降低。 Carboxyl functional ionic liquid with benzotriazole cation and trifluoroacetate anion can be used as environmental-friendly catalyst for the efficient synthesis of 3,4-dihydropyrimidin-2(1H) ones /thiones under solvent-free conditions. Moreover, the ionic liquid [C2O2BBTA][TFA] can be easily recycled and reused for at least four cycles without obvious loss of catalytic activity.","PeriodicalId":16596,"journal":{"name":"Journal of Organic Chemistry Research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72923457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-03-08DOI: 10.12677/JOCR.2017.51004
甄文, 王南翔, 祁欣
荧光光谱和荧光成像是当今科学研究必不可少的工具。在近几年飞速发展的研究进展中，有机荧光染料已被广泛应用于蛋白质标记、DNA检测和环境检测等领域。BODIPY荧光染料因其独特优良的光动力学性质而在众多荧光染料中显得格外耀眼，并逐渐成为科研工作者的研究焦点。荧光分析法具有高选择性、高灵敏度、高荧光量子产率等优点。 Fluorescence spectroscopy and fluorescence imaging are becoming indispensable tools in today’s scientific research. With the rapid development of research, organic fluorescent dyes have been widely used in protein labeling, DNA detection and environmental testing. Because of its excellent photodynamic properties, BODIPY fluorescent dyes are particularly bright in a large number of fluorescent dyes. Fluorescence analysis has the advantages of high selectivity, high sensitivity and high fluorescence quantum yield.
荧光光谱和荧光成像是当今科学研究必不可少的工具。在近几年飞速发展的研究进展中，有机荧光染料已被广泛应用于蛋白质标记、DNA检测和环境检测等领域。BODIPY荧光染料因其独特优良的光动力学性质而在众多荧光染料中显得格外耀眼，并逐渐成为科研工作者的研究焦点。荧光分析法具有高选择性、高灵敏度、高荧光量子产率等优点。 Fluorescence spectroscopy and fluorescence imaging are becoming indispensable tools in today’s scientific research. With the rapid development of research, organic fluorescent dyes have been widely used in protein labeling, DNA detection and environmental testing. Because of its excellent photodynamic properties, BODIPY fluorescent dyes are particularly bright in a large number of fluorescent dyes. Fluorescence analysis has the advantages of high selectivity, high sensitivity and high fluorescence quantum yield.
{"title":"荧光染料的简介及BODIPY类的发展历程 Introduction to Fluorescent Dyes and Development of BODIPY Classes","authors":"甄文, 王南翔, 祁欣","doi":"10.12677/JOCR.2017.51004","DOIUrl":"https://doi.org/10.12677/JOCR.2017.51004","url":null,"abstract":"荧光光谱和荧光成像是当今科学研究必不可少的工具。在近几年飞速发展的研究进展中，有机荧光染料已被广泛应用于蛋白质标记、DNA检测和环境检测等领域。BODIPY荧光染料因其独特优良的光动力学性质而在众多荧光染料中显得格外耀眼，并逐渐成为科研工作者的研究焦点。荧光分析法具有高选择性、高灵敏度、高荧光量子产率等优点。 Fluorescence spectroscopy and fluorescence imaging are becoming indispensable tools in today’s scientific research. With the rapid development of research, organic fluorescent dyes have been widely used in protein labeling, DNA detection and environmental testing. Because of its excellent photodynamic properties, BODIPY fluorescent dyes are particularly bright in a large number of fluorescent dyes. Fluorescence analysis has the advantages of high selectivity, high sensitivity and high fluorescence quantum yield.","PeriodicalId":16596,"journal":{"name":"Journal of Organic Chemistry Research","volume":"102 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75759193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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