Pub Date : 2017-03-08DOI: 10.12677/JOCR.2017.51007
程丽红, 林燕飞, 王艳惠, 朴金株, 金泰硕, 向兰, 吕翼炫, 戚建华
本研究采用酵母突变株K6001作为生物活性筛选系统，对韩国圃美多公司多个产品进行筛选，发现玛咖超临界提取粉末具有较好的抗衰老活性。因此对该原料中的抗衰老活性物质进行了研究并从中分离得到了两个活性化合物(1, 2)。这两个化合物都能显著延长酵母突变株的复制性寿命。通过波谱分析以及文献数据比对，推测活性化合物1的结构为n-benzyl-(9Z)-octadecenamide(1)，确定活性化合物2的结构为n-benzylmyristamide(2)。为了进一步确认化合物1的结构，合成了n-benzyl-(9Z)-octadecena- mide(1)，并且测定了其生物活性，结果表明合成得到的n-benzyl-(9Z)-octadecenamide的波谱数据及生物活性与天然来源的化合物1相同。 Extracts of several products of Pulmuone were screened for their anti-aging activity using the K6001 yeast strain bioassay system. Maca supercritical extract significantly exhibited anti-aging activity and two active compounds were isolated from the extract. The structures were elucidated by the spectroscopic data and comparison with those reported. One structure was proposed to be n-benzyl-(9Z)-octadecenamide (1), and another was identified as n-benzylmyristamide (2). Both compounds significantly extended the replicative lifespan of K6001 yeast strain. To confirm the structure of compound 1, n-benzyl-(9Z)-octadecenamide (1) was synthesized and biological activity was evaluated. The synthesized n-benzyl-(9Z)-octadecenamide (1) is identical to natural compound 1 from spectroscopic data and biological activity.
本研究采用酵母突变株K6001作为生物活性筛选系统，对韩国圃美多公司多个产品进行筛选，发现玛咖超临界提取粉末具有较好的抗衰老活性。因此对该原料中的抗衰老活性物质进行了研究并从中分离得到了两个活性化合物(1, 2)。这两个化合物都能显著延长酵母突变株的复制性寿命。通过波谱分析以及文献数据比对，推测活性化合物1的结构为n-benzyl-(9Z)-octadecenamide(1)，确定活性化合物2的结构为n-benzylmyristamide(2)。为了进一步确认化合物1的结构，合成了n-benzyl-(9Z)-octadecena- mide(1)，并且测定了其生物活性，结果表明合成得到的n-benzyl-(9Z)-octadecenamide的波谱数据及生物活性与天然来源的化合物1相同。 Extracts of several products of Pulmuone were screened for their anti-aging activity using the K6001 yeast strain bioassay system. Maca supercritical extract significantly exhibited anti-aging activity and two active compounds were isolated from the extract. The structures were elucidated by the spectroscopic data and comparison with those reported. One structure was proposed to be n-benzyl-(9Z)-octadecenamide (1), and another was identified as n-benzylmyristamide (2). Both compounds significantly extended the replicative lifespan of K6001 yeast strain. To confirm the structure of compound 1, n-benzyl-(9Z)-octadecenamide (1) was synthesized and biological activity was evaluated. The synthesized n-benzyl-(9Z)-octadecenamide (1) is identical to natural compound 1 from spectroscopic data and biological activity.
{"title":"玛咖超临界提取物中的抗衰老活性物质 Anti-Aging Substances from Maca Supercritical Extract","authors":"程丽红, 林燕飞, 王艳惠, 朴金株, 金泰硕, 向兰, 吕翼炫, 戚建华","doi":"10.12677/JOCR.2017.51007","DOIUrl":"https://doi.org/10.12677/JOCR.2017.51007","url":null,"abstract":"本研究采用酵母突变株K6001作为生物活性筛选系统，对韩国圃美多公司多个产品进行筛选，发现玛咖超临界提取粉末具有较好的抗衰老活性。因此对该原料中的抗衰老活性物质进行了研究并从中分离得到了两个活性化合物(1, 2)。这两个化合物都能显著延长酵母突变株的复制性寿命。通过波谱分析以及文献数据比对，推测活性化合物1的结构为n-benzyl-(9Z)-octadecenamide(1)，确定活性化合物2的结构为n-benzylmyristamide(2)。为了进一步确认化合物1的结构，合成了n-benzyl-(9Z)-octadecena- mide(1)，并且测定了其生物活性，结果表明合成得到的n-benzyl-(9Z)-octadecenamide的波谱数据及生物活性与天然来源的化合物1相同。 Extracts of several products of Pulmuone were screened for their anti-aging activity using the K6001 yeast strain bioassay system. Maca supercritical extract significantly exhibited anti-aging activity and two active compounds were isolated from the extract. The structures were elucidated by the spectroscopic data and comparison with those reported. One structure was proposed to be n-benzyl-(9Z)-octadecenamide (1), and another was identified as n-benzylmyristamide (2). Both compounds significantly extended the replicative lifespan of K6001 yeast strain. To confirm the structure of compound 1, n-benzyl-(9Z)-octadecenamide (1) was synthesized and biological activity was evaluated. The synthesized n-benzyl-(9Z)-octadecenamide (1) is identical to natural compound 1 from spectroscopic data and biological activity.","PeriodicalId":16596,"journal":{"name":"Journal of Organic Chemistry Research","volume":"9 1","pages":"45-50"},"PeriodicalIF":0.0,"publicationDate":"2017-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88463618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-03-08DOI: 10.12677/JOCR.2017.51002
莫松, 王帅, 张刚, 杓学蓓, 李清寒, 杨学军
以2-氨基-4-甲基苯酚、二硫化碳和3-溴丙炔为原料，经环化、取代、Click反应合成了8个新的2-(l-取代-1H-[1,2,3]-三氮唑-4-甲硫基)-5-甲基苯并噁唑化合物3(a~h)。其结构均经质谱，氢核磁共振和元素分析所确证。经体外抗肿瘤活性测试表明，在20 uM的浓度下，有4个化合物对CDC25B具有较好的抑制活性，其抑制率高达68.18%，IC50可达13.23 ug/mL。 Eight new 2-(1-benzyl-1H-[1,2,3]-triazol-4-methylthio)-5-methylbenzoxazole 3(a~h) were synthe-sized with 2-amino-4-methylphenol, methanedithione and 3-bromoprop-1-yne as starting material, followed by cyclo reaction, substitute reaction and Click reaction. Their structures have been determined by elemental analysis, IR, MS and 1H NMR data. The bioactive assay for the newly pre-pared compounds manifested that four compounds exhibited good inhibitory activity against CDC25B in 20 uM (IC50 value up to 13.23 ug/mL).
以2-氨基-4-甲基苯酚、二硫化碳和3-溴丙炔为原料，经环化、取代、Click反应合成了8个新的2-(l-取代-1H-[1,2,3]-三氮唑-4-甲硫基)-5-甲基苯并噁唑化合物3(a~h)。其结构均经质谱，氢核磁共振和元素分析所确证。经体外抗肿瘤活性测试表明，在20 uM的浓度下，有4个化合物对CDC25B具有较好的抑制活性，其抑制率高达68.18%，IC50可达13.23 ug/mL。 Eight new 2-(1-benzyl-1H-[1,2,3]-triazol-4-methylthio)-5-methylbenzoxazole 3(a~h) were synthe-sized with 2-amino-4-methylphenol, methanedithione and 3-bromoprop-1-yne as starting material, followed by cyclo reaction, substitute reaction and Click reaction. Their structures have been determined by elemental analysis, IR, MS and 1H NMR data. The bioactive assay for the newly pre-pared compounds manifested that four compounds exhibited good inhibitory activity against CDC25B in 20 uM (IC50 value up to 13.23 ug/mL).
{"title":"2-(l-取代-1H-[1,2,3]-三氮唑-4-甲硫基)-5-甲基苯并噁唑化合物的合成及其抗肿瘤活性研究 Synthesis and Antitumor Activities of 2-(1-Substitute-1H-[1,2,3]-Triazol-4-Methylthio)-5-Methylbenzoxazole","authors":"莫松, 王帅, 张刚, 杓学蓓, 李清寒, 杨学军","doi":"10.12677/JOCR.2017.51002","DOIUrl":"https://doi.org/10.12677/JOCR.2017.51002","url":null,"abstract":"以2-氨基-4-甲基苯酚、二硫化碳和3-溴丙炔为原料，经环化、取代、Click反应合成了8个新的2-(l-取代-1H-[1,2,3]-三氮唑-4-甲硫基)-5-甲基苯并噁唑化合物3(a~h)。其结构均经质谱，氢核磁共振和元素分析所确证。经体外抗肿瘤活性测试表明，在20 uM的浓度下，有4个化合物对CDC25B具有较好的抑制活性，其抑制率高达68.18%，IC50可达13.23 ug/mL。 Eight new 2-(1-benzyl-1H-[1,2,3]-triazol-4-methylthio)-5-methylbenzoxazole 3(a~h) were synthe-sized with 2-amino-4-methylphenol, methanedithione and 3-bromoprop-1-yne as starting material, followed by cyclo reaction, substitute reaction and Click reaction. Their structures have been determined by elemental analysis, IR, MS and 1H NMR data. The bioactive assay for the newly pre-pared compounds manifested that four compounds exhibited good inhibitory activity against CDC25B in 20 uM (IC50 value up to 13.23 ug/mL).","PeriodicalId":16596,"journal":{"name":"Journal of Organic Chemistry Research","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79111834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-03-08DOI: 10.12677/JOCR.2017.51005
朱雅亮, 段英香, 沈应中
本文主要讲述了3,5-二氨基-4’-(α-萘基)萘基二苯甲酮的合成。产物及相关的中间体都通过1H NMR, 13C NMR、红外光谱和元素分析进行了表征。该方法简单、产率较高，而且不会对环境造成污染。 This paper mainly described the synthesis of (4-([1,1'-binaphthalen]-4-yl)phenyl)(3,5-diamino- phenyl)methanone. All the compounds and related intermediates were confirmed by 1H NMR, 13C NMR, IR spectrography and element analysis. This method is simple, with a high yield and envi-ronmental-friendly.
本文主要讲述了3,5-二氨基-4’-(α-萘基)萘基二苯甲酮的合成。产物及相关的中间体都通过1H NMR, 13C NMR、红外光谱和元素分析进行了表征。该方法简单、产率较高，而且不会对环境造成污染。 This paper mainly described the synthesis of (4-([1,1'-binaphthalen]-4-yl)phenyl)(3,5-diamino- phenyl)methanone. All the compounds and related intermediates were confirmed by 1H NMR, 13C NMR, IR spectrography and element analysis. This method is simple, with a high yield and envi-ronmental-friendly.
{"title":"3,5-二氨基-4’-(α-萘基)萘基二苯甲酮的合成与表征 Synthesis and Characterization of (4-([1,1'-Binaphthalen]-4-yl)Phenyl)(3,5-Diaminophenyl)Methanone","authors":"朱雅亮, 段英香, 沈应中","doi":"10.12677/JOCR.2017.51005","DOIUrl":"https://doi.org/10.12677/JOCR.2017.51005","url":null,"abstract":"本文主要讲述了3,5-二氨基-4’-(α-萘基)萘基二苯甲酮的合成。产物及相关的中间体都通过1H NMR, 13C NMR、红外光谱和元素分析进行了表征。该方法简单、产率较高，而且不会对环境造成污染。 This paper mainly described the synthesis of (4-([1,1'-binaphthalen]-4-yl)phenyl)(3,5-diamino- phenyl)methanone. All the compounds and related intermediates were confirmed by 1H NMR, 13C NMR, IR spectrography and element analysis. This method is simple, with a high yield and envi-ronmental-friendly.","PeriodicalId":16596,"journal":{"name":"Journal of Organic Chemistry Research","volume":"27 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83410908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-03-08DOI: 10.12677/JOCR.2017.51006
宋阳君, 赵倩, 朱雅亮, 王立君, 沈应中
丙炔醇是一类重要的中间产物，其在医药和材料领域都有很广泛的应用。本文以4,4’-二甲氧基二苯甲酮为原料通过Suzuki等反应合成1,1-双(6-甲氧基-4'-(萘-1-基)-[1,1'-联苯]-3-基)丙-2-炔-1-醇，并通过核磁共振氢谱和核磁共振碳谱手段对中间产物和最终产物进行表征。 Propynol is an important intermediate and organic chemical raw material. It has a very wide range of applications in the field of medicine and materials. 1,1-bis(6-methoxy-4'-(naph-thalen-1- yl)-[1,1'-biphenyl]-3-yl)prop-2-yn-1-ol was efficiently synthesized by bis(4-methoxyphenyl)me- thanone. The product was well characterized by 1H NMR and13C NMR.
丙炔醇是一类重要的中间产物，其在医药和材料领域都有很广泛的应用。本文以4,4’-二甲氧基二苯甲酮为原料通过Suzuki等反应合成1,1-双(6-甲氧基-4'-(萘-1-基)-[1,1'-联苯]-3-基)丙-2-炔-1-醇，并通过核磁共振氢谱和核磁共振碳谱手段对中间产物和最终产物进行表征。 Propynol is an important intermediate and organic chemical raw material. It has a very wide range of applications in the field of medicine and materials. 1,1-bis(6-methoxy-4'-(naph-thalen-1- yl)-[1,1'-biphenyl]-3-yl)prop-2-yn-1-ol was efficiently synthesized by bis(4-methoxyphenyl)me- thanone. The product was well characterized by 1H NMR and13C NMR.
{"title":"1,1-双(6-甲氧基-4'-(萘-1-基)-[1,1'-联苯]-3-基)丙-2-炔-1-醇的合成与分析 Synthesis and Analysis of 1,1-Bis(6-Methoxy-4'-(Naphthalen-1-Yl)-[1,1'-Biphenyl]-3-Yl)Prop-2-Yn-1-Ol","authors":"宋阳君, 赵倩, 朱雅亮, 王立君, 沈应中","doi":"10.12677/JOCR.2017.51006","DOIUrl":"https://doi.org/10.12677/JOCR.2017.51006","url":null,"abstract":"丙炔醇是一类重要的中间产物，其在医药和材料领域都有很广泛的应用。本文以4,4’-二甲氧基二苯甲酮为原料通过Suzuki等反应合成1,1-双(6-甲氧基-4'-(萘-1-基)-[1,1'-联苯]-3-基)丙-2-炔-1-醇，并通过核磁共振氢谱和核磁共振碳谱手段对中间产物和最终产物进行表征。 Propynol is an important intermediate and organic chemical raw material. It has a very wide range of applications in the field of medicine and materials. 1,1-bis(6-methoxy-4'-(naph-thalen-1- yl)-[1,1'-biphenyl]-3-yl)prop-2-yn-1-ol was efficiently synthesized by bis(4-methoxyphenyl)me- thanone. The product was well characterized by 1H NMR and13C NMR.","PeriodicalId":16596,"journal":{"name":"Journal of Organic Chemistry Research","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75800019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-03-08DOI: 10.12677/JOCR.2017.51008
张剑, 魏一飞, 罗人仕
手性芳基氧杂化合物在药物化学和临床治疗上有着及其重要的作用。酚与不同的反应底物发生不对称反应是获得此类化合物的重要途径。在手性催化剂的作用下，以酚为亲核试剂，与不同的反应底物可发生不对称取代、Oxa-Michael加成、开环、Wacker-Type环化、O-H插入等获得手性芳基氧杂化合物。近年来，酚参与不对称C-O键形成取得了较大的进展，本文将对该进展做重点介绍。 Chiral aryl oxa-compounds are extremely important in medicinal chemistry and clinical therapies. The asymmetric reactions of phenols with different substrates are important methodologies to synthesize such species. With phenols as nucleophilic reagents, the chiral catalysts-catalyzed asymmetric reactions, such as substitution, Oxa-Michael addition, ring-opening, Wacker-Type cy-clization, O-H insertion, can be developed by reacting with different substrates to obtain such compounds. Recently, the asymmetric C-O bond formation with phenols has made a great progress. This paper will focus on the progress of the asymmetric C-O bond formation with phenols.
手性芳基氧杂化合物在药物化学和临床治疗上有着及其重要的作用。酚与不同的反应底物发生不对称反应是获得此类化合物的重要途径。在手性催化剂的作用下，以酚为亲核试剂，与不同的反应底物可发生不对称取代、Oxa-Michael加成、开环、Wacker-Type环化、O-H插入等获得手性芳基氧杂化合物。近年来，酚参与不对称C-O键形成取得了较大的进展，本文将对该进展做重点介绍。 Chiral aryl oxa-compounds are extremely important in medicinal chemistry and clinical therapies. The asymmetric reactions of phenols with different substrates are important methodologies to synthesize such species. With phenols as nucleophilic reagents, the chiral catalysts-catalyzed asymmetric reactions, such as substitution, Oxa-Michael addition, ring-opening, Wacker-Type cy-clization, O-H insertion, can be developed by reacting with different substrates to obtain such compounds. Recently, the asymmetric C-O bond formation with phenols has made a great progress. This paper will focus on the progress of the asymmetric C-O bond formation with phenols.
{"title":"酚参与的不对称C-O键形成研究进展 Progress on Asymmetric C-O Bond Formation with Phenols","authors":"张剑, 魏一飞, 罗人仕","doi":"10.12677/JOCR.2017.51008","DOIUrl":"https://doi.org/10.12677/JOCR.2017.51008","url":null,"abstract":"手性芳基氧杂化合物在药物化学和临床治疗上有着及其重要的作用。酚与不同的反应底物发生不对称反应是获得此类化合物的重要途径。在手性催化剂的作用下，以酚为亲核试剂，与不同的反应底物可发生不对称取代、Oxa-Michael加成、开环、Wacker-Type环化、O-H插入等获得手性芳基氧杂化合物。近年来，酚参与不对称C-O键形成取得了较大的进展，本文将对该进展做重点介绍。 Chiral aryl oxa-compounds are extremely important in medicinal chemistry and clinical therapies. The asymmetric reactions of phenols with different substrates are important methodologies to synthesize such species. With phenols as nucleophilic reagents, the chiral catalysts-catalyzed asymmetric reactions, such as substitution, Oxa-Michael addition, ring-opening, Wacker-Type cy-clization, O-H insertion, can be developed by reacting with different substrates to obtain such compounds. Recently, the asymmetric C-O bond formation with phenols has made a great progress. This paper will focus on the progress of the asymmetric C-O bond formation with phenols.","PeriodicalId":16596,"journal":{"name":"Journal of Organic Chemistry Research","volume":"87 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75231146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-03-08DOI: 10.12677/JOCR.2017.51003
王南翔, 甄文
近年来，氟硼二吡咯（BODIPY）类荧光化合物在生物标记、肿瘤光动力治疗（PDT）光敏剂、固态太阳能聚光器电致发光器件、荧光开光等不同领域中都成为了研究的焦点，特别是在传感器和生物探针方面。本文总结了BODIPY类化合物的多种合成及其修饰方法，希望对相关研究人员有所帮助。 In recent years, BODIPY (Boron-dipyrromethene complex) compounds have been the focus of many studies in diverse areas. BODIPYs are fully recognized as excellent fluorescent materials in tunable laser, biological labeling, photosensitizers and photodynamic therapy of tumor (PDT), solid-state solar concentrators, electroluminescent devices, on-off fluorescent switches etc., and in particular the fluorophores in sensors and probes. This paper summarizes the synthesis of BODIPY compounds and its modification methods, hoping to help the relevant researchers.
近年来，氟硼二吡咯（BODIPY）类荧光化合物在生物标记、肿瘤光动力治疗（PDT）光敏剂、固态太阳能聚光器电致发光器件、荧光开光等不同领域中都成为了研究的焦点，特别是在传感器和生物探针方面。本文总结了BODIPY类化合物的多种合成及其修饰方法，希望对相关研究人员有所帮助。 In recent years, BODIPY (Boron-dipyrromethene complex) compounds have been the focus of many studies in diverse areas. BODIPYs are fully recognized as excellent fluorescent materials in tunable laser, biological labeling, photosensitizers and photodynamic therapy of tumor (PDT), solid-state solar concentrators, electroluminescent devices, on-off fluorescent switches etc., and in particular the fluorophores in sensors and probes. This paper summarizes the synthesis of BODIPY compounds and its modification methods, hoping to help the relevant researchers.
{"title":"BODIPY类化合物的合成及其修饰方法概况 Synthesis of BODIPY Compounds and Their Modification Methods","authors":"王南翔, 甄文","doi":"10.12677/JOCR.2017.51003","DOIUrl":"https://doi.org/10.12677/JOCR.2017.51003","url":null,"abstract":"近年来，氟硼二吡咯（BODIPY）类荧光化合物在生物标记、肿瘤光动力治疗（PDT）光敏剂、固态太阳能聚光器电致发光器件、荧光开光等不同领域中都成为了研究的焦点，特别是在传感器和生物探针方面。本文总结了BODIPY类化合物的多种合成及其修饰方法，希望对相关研究人员有所帮助。 In recent years, BODIPY (Boron-dipyrromethene complex) compounds have been the focus of many studies in diverse areas. BODIPYs are fully recognized as excellent fluorescent materials in tunable laser, biological labeling, photosensitizers and photodynamic therapy of tumor (PDT), solid-state solar concentrators, electroluminescent devices, on-off fluorescent switches etc., and in particular the fluorophores in sensors and probes. This paper summarizes the synthesis of BODIPY compounds and its modification methods, hoping to help the relevant researchers.","PeriodicalId":16596,"journal":{"name":"Journal of Organic Chemistry Research","volume":"42 1","pages":"15-20"},"PeriodicalIF":0.0,"publicationDate":"2017-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85466168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-01-01DOI: 10.12677/JOCR.2017.52011
马 雪成
{"title":"The Michael Addition Reaction of Indoles and α, β-Unsaturated Ketones Catalyzed by Br∅nsted Acidic Ionic Liquid","authors":"马 雪成","doi":"10.12677/JOCR.2017.52011","DOIUrl":"https://doi.org/10.12677/JOCR.2017.52011","url":null,"abstract":"","PeriodicalId":16596,"journal":{"name":"Journal of Organic Chemistry Research","volume":"1 1","pages":"86-93"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76336146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-01-01DOI: 10.12677/JOCR.2017.51001
刘 巧茹
{"title":"Study on Synthesis, Crystal Structure and Fluorescence Properties of Schiff Base from 4-Aminoantipyrine","authors":"刘 巧茹","doi":"10.12677/JOCR.2017.51001","DOIUrl":"https://doi.org/10.12677/JOCR.2017.51001","url":null,"abstract":"","PeriodicalId":16596,"journal":{"name":"Journal of Organic Chemistry Research","volume":"67 1","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84056602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-01-01DOI: 10.12677/JOCR.2017.53018
曹 忠民
{"title":"Studies on the International Nomenclature of Organic Chemistry: (I) Functional Group and Characteristic Group","authors":"曹 忠民","doi":"10.12677/JOCR.2017.53018","DOIUrl":"https://doi.org/10.12677/JOCR.2017.53018","url":null,"abstract":"","PeriodicalId":16596,"journal":{"name":"Journal of Organic Chemistry Research","volume":"96 1","pages":"137-141"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77327232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-12-02DOI: 10.12677/JOCR.2016.44015
陈向莹, 范芳芳, 夏佳美, 张千峰
以2-巯基-4-甲基嘧啶盐酸盐为原料，与2-氯甲基-4-甲氧基-3,5-二甲基吡啶盐酸盐、甲醇钠反应，合成4-甲基-2-[(3,5-二甲基-4-甲氧基-2-吡啶基)甲硫基]-嘧啶。并通过1H NMR、FT-IR表征手段，对产物4-甲基-2-[(3,5-二甲基-4-甲氧基-2-吡啶基)甲硫基]-嘧啶进行谱学分析。 4-Methyl-2-[(3,5-dimethyl-4-methoxy-2-pyridine)methylmercapto]-pyrimidine was efficiently synthesized by reaction of 2-mercapto-4-methylpyrimidine hydrochloride and 2-chloromethyl-3,5- dimethyl-4-methoxypyridine hydrochloride in the presence of sodium methoxide. The product was well characterized by 1H NMR and FT-IR spectroscopies.
以2-巯基-4-甲基嘧啶盐酸盐为原料，与2-氯甲基-4-甲氧基-3,5-二甲基吡啶盐酸盐、甲醇钠反应，合成4-甲基-2-[(3,5-二甲基-4-甲氧基-2-吡啶基)甲硫基]-嘧啶。并通过1H NMR、FT-IR表征手段，对产物4-甲基-2-[(3,5-二甲基-4-甲氧基-2-吡啶基)甲硫基]-嘧啶进行谱学分析。 4-Methyl-2-[(3,5-dimethyl-4-methoxy-2-pyridine)methylmercapto]-pyrimidine was efficiently synthesized by reaction of 2-mercapto-4-methylpyrimidine hydrochloride and 2-chloromethyl-3,5- dimethyl-4-methoxypyridine hydrochloride in the presence of sodium methoxide. The product was well characterized by 1H NMR and FT-IR spectroscopies.
{"title":"4-甲基-2-[(3,5-二甲基-4-甲氧基-2-吡啶基)甲硫基]-嘧啶的合成与分析 Synthesis and Analysis of 4-Methyl-2-[(3,5-Dimethyl-4-Methoxy-2-Pyridine)Methylmercapto]-Pyrimidine","authors":"陈向莹, 范芳芳, 夏佳美, 张千峰","doi":"10.12677/JOCR.2016.44015","DOIUrl":"https://doi.org/10.12677/JOCR.2016.44015","url":null,"abstract":"以2-巯基-4-甲基嘧啶盐酸盐为原料，与2-氯甲基-4-甲氧基-3,5-二甲基吡啶盐酸盐、甲醇钠反应，合成4-甲基-2-[(3,5-二甲基-4-甲氧基-2-吡啶基)甲硫基]-嘧啶。并通过1H NMR、FT-IR表征手段，对产物4-甲基-2-[(3,5-二甲基-4-甲氧基-2-吡啶基)甲硫基]-嘧啶进行谱学分析。 4-Methyl-2-[(3,5-dimethyl-4-methoxy-2-pyridine)methylmercapto]-pyrimidine was efficiently synthesized by reaction of 2-mercapto-4-methylpyrimidine hydrochloride and 2-chloromethyl-3,5- dimethyl-4-methoxypyridine hydrochloride in the presence of sodium methoxide. The product was well characterized by 1H NMR and FT-IR spectroscopies.","PeriodicalId":16596,"journal":{"name":"Journal of Organic Chemistry Research","volume":"95 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78080344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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